TMEM39B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.16730855
2pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.14535186
3protein deneddylation (GO:0000338)5.04636095
4protein neddylation (GO:0045116)4.80068620
5DNA strand elongation involved in DNA replication (GO:0006271)4.77817199
6chaperone-mediated protein transport (GO:0072321)4.76165127
7cullin deneddylation (GO:0010388)4.74894175
8ribosomal small subunit assembly (GO:0000028)4.58957762
9DNA replication initiation (GO:0006270)4.55559246
10telomere maintenance via semi-conservative replication (GO:0032201)4.54624455
11DNA strand elongation (GO:0022616)4.53037414
12base-excision repair, AP site formation (GO:0006285)4.51751270
13iron-sulfur cluster assembly (GO:0016226)4.40808629
14metallo-sulfur cluster assembly (GO:0031163)4.40808629
15DNA unwinding involved in DNA replication (GO:0006268)4.38625404
16pyrimidine nucleotide catabolic process (GO:0006244)4.31730613
17viral transcription (GO:0019083)4.29152396
18maturation of SSU-rRNA (GO:0030490)4.25755843
19deoxyribonucleotide catabolic process (GO:0009264)4.24454444
20pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.23436703
21regulation of mitochondrial translation (GO:0070129)4.20484159
22translational termination (GO:0006415)4.17352206
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14245272
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.14245272
25NADH dehydrogenase complex assembly (GO:0010257)4.14245272
26protein localization to kinetochore (GO:0034501)4.14162640
27protein complex biogenesis (GO:0070271)4.12084791
28purine nucleotide salvage (GO:0032261)4.02094448
29deoxyribose phosphate catabolic process (GO:0046386)4.00485589
30formation of translation preinitiation complex (GO:0001731)3.97211484
31telomere maintenance via recombination (GO:0000722)3.94959894
32establishment of viral latency (GO:0019043)3.93193890
33translational elongation (GO:0006414)3.89271786
34protein localization to chromosome, centromeric region (GO:0071459)3.87577042
35mitochondrial respiratory chain complex assembly (GO:0033108)3.82831966
36nucleobase biosynthetic process (GO:0046112)3.78562574
37deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.75977004
38telomere maintenance via telomere lengthening (GO:0010833)3.70527816
39translational initiation (GO:0006413)3.69748347
40sequestering of actin monomers (GO:0042989)3.68272292
41mitotic recombination (GO:0006312)3.67440367
42purine deoxyribonucleotide catabolic process (GO:0009155)3.67315307
43protein targeting to mitochondrion (GO:0006626)3.65860504
44mitotic nuclear envelope disassembly (GO:0007077)3.65804982
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.63983592
46nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.62496581
47DNA damage response, detection of DNA damage (GO:0042769)3.61465108
48DNA replication checkpoint (GO:0000076)3.59086322
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.58730070
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.58730070
51folic acid-containing compound biosynthetic process (GO:0009396)3.57997063
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56253920
53SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51156302
542-deoxyribonucleotide metabolic process (GO:0009394)3.50921592
55protein maturation by protein folding (GO:0022417)3.46008750
56purine nucleobase biosynthetic process (GO:0009113)3.45276664
57guanosine-containing compound biosynthetic process (GO:1901070)3.44404971
58establishment of protein localization to mitochondrion (GO:0072655)3.42618087
59IMP biosynthetic process (GO:0006188)3.40945814
60GMP metabolic process (GO:0046037)3.40625079
61CENP-A containing nucleosome assembly (GO:0034080)3.39495874
62cotranslational protein targeting to membrane (GO:0006613)3.39304647
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38891592
64ribosome assembly (GO:0042255)3.38528908
65energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38307676
66ATP synthesis coupled proton transport (GO:0015986)3.38307676
67protein targeting to ER (GO:0045047)3.38185640
68ribosomal large subunit biogenesis (GO:0042273)3.38074654
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.38025052
70chromatin remodeling at centromere (GO:0031055)3.37324539
71ribosomal small subunit biogenesis (GO:0042274)3.37303467
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35504377
73intra-S DNA damage checkpoint (GO:0031573)3.35104123
74DNA replication-dependent nucleosome assembly (GO:0006335)3.34581855
75DNA replication-dependent nucleosome organization (GO:0034723)3.34581855
76deoxyribose phosphate metabolic process (GO:0019692)3.34317197
77nuclear envelope disassembly (GO:0051081)3.32777219
78membrane disassembly (GO:0030397)3.32777219
79DNA replication-independent nucleosome organization (GO:0034724)3.32164027
80DNA replication-independent nucleosome assembly (GO:0006336)3.32164027
81negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31985569
82protein insertion into membrane (GO:0051205)3.31860125
83nucleotide salvage (GO:0043173)3.30837496
84protein localization to mitochondrion (GO:0070585)3.30784944
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29201864
86negative regulation of RNA splicing (GO:0033119)3.29138198
87negative regulation of B cell apoptotic process (GO:0002903)3.28779766
88translesion synthesis (GO:0019985)3.28340711
89cellular protein complex disassembly (GO:0043624)3.25246842
90pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.25010163
91viral life cycle (GO:0019058)3.23425092
92pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.22640473
93termination of RNA polymerase III transcription (GO:0006386)3.22057536
94transcription elongation from RNA polymerase III promoter (GO:0006385)3.22057536
95establishment of protein localization to endoplasmic reticulum (GO:0072599)3.18789314
96histone H2A acetylation (GO:0043968)3.18232671
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17469257
98protein localization to endoplasmic reticulum (GO:0070972)3.17419091
99ribonucleoprotein complex biogenesis (GO:0022613)3.16626403
100negative regulation of telomere maintenance (GO:0032205)3.16570030
101GTP biosynthetic process (GO:0006183)3.16567823
102IMP metabolic process (GO:0046040)3.14366559
103pseudouridine synthesis (GO:0001522)3.13896593
104de novo posttranslational protein folding (GO:0051084)3.13574634
105de novo protein folding (GO:0006458)3.13562871
106nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12809164
107mitotic metaphase plate congression (GO:0007080)3.12373923
108purine-containing compound salvage (GO:0043101)3.12283445
109deoxyribonucleotide metabolic process (GO:0009262)3.12119347
110spliceosomal snRNP assembly (GO:0000387)3.12034277
111DNA double-strand break processing (GO:0000729)3.10219100
112negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.10194986
113negative regulation of DNA-templated transcription, elongation (GO:0032785)3.10194986
114ribosome biogenesis (GO:0042254)3.09789642
115mitochondrial calcium ion transport (GO:0006851)3.09723213
116respiratory electron transport chain (GO:0022904)3.09699197
117protein complex disassembly (GO:0043241)3.09104204
118histone exchange (GO:0043486)3.07847571
119rRNA processing (GO:0006364)3.07634966
120attachment of spindle microtubules to kinetochore (GO:0008608)3.06608602
121mitotic chromosome condensation (GO:0007076)3.04808178
122electron transport chain (GO:0022900)3.03169527
123folic acid metabolic process (GO:0046655)3.02213789
124kinetochore organization (GO:0051383)3.02142518
125UTP biosynthetic process (GO:0006228)3.00248468
126nuclear-transcribed mRNA catabolic process (GO:0000956)2.99612074
127protein-cofactor linkage (GO:0018065)2.99145904
128deoxyribose phosphate biosynthetic process (GO:0046385)2.97581559
1292-deoxyribonucleotide biosynthetic process (GO:0009265)2.97581559
130rRNA metabolic process (GO:0016072)2.96846615
131nucleoside salvage (GO:0043174)2.94958534
132purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.94687215
133termination of RNA polymerase II transcription (GO:0006369)2.94577317
134respiratory chain complex IV assembly (GO:0008535)2.93992799
135platelet dense granule organization (GO:0060155)2.92300429
136purine deoxyribonucleotide metabolic process (GO:0009151)2.92003064
137base-excision repair (GO:0006284)2.91605604
138establishment of integrated proviral latency (GO:0075713)2.91004536
139DNA duplex unwinding (GO:0032508)2.89834283
140negative regulation of ligase activity (GO:0051352)2.89081017
141negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89081017
142macromolecular complex disassembly (GO:0032984)2.88695535
143mitotic sister chromatid segregation (GO:0000070)2.88504444
144DNA geometric change (GO:0032392)2.87099682
145exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86515658
146chromatin assembly or disassembly (GO:0006333)2.86148852
147positive regulation of mitochondrial fission (GO:0090141)2.86096507
148mRNA catabolic process (GO:0006402)2.84954096
149RNA catabolic process (GO:0006401)2.84017237
150kinetochore assembly (GO:0051382)2.82687909
151cytochrome complex assembly (GO:0017004)2.82672841
152regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82174628
153transcription-coupled nucleotide-excision repair (GO:0006283)2.81933334
154protein localization to chromosome (GO:0034502)2.81896320
155RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.81886891
156mRNA splicing, via spliceosome (GO:0000398)2.81886891
157negative regulation of chromosome segregation (GO:0051985)2.81765723
158ubiquinone biosynthetic process (GO:0006744)2.81724011
159rRNA modification (GO:0000154)2.81574189
160tRNA modification (GO:0006400)2.81017912
161peptidyl-arginine omega-N-methylation (GO:0035247)2.80711402
162positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.80103948
163RNA splicing, via transesterification reactions (GO:0000375)2.79699371
164mismatch repair (GO:0006298)2.78990556
165regulation of histone H3-K9 methylation (GO:0051570)2.78917434
166CTP metabolic process (GO:0046036)2.78866106
167CTP biosynthetic process (GO:0006241)2.78866106
168negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.78593710
169negative regulation of sister chromatid segregation (GO:0033046)2.78593710
170negative regulation of mitotic sister chromatid separation (GO:2000816)2.78593710
171negative regulation of mitotic sister chromatid segregation (GO:0033048)2.78593710
172proteasome assembly (GO:0043248)2.77590903
173negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76993002
174nuclear envelope reassembly (GO:0031468)2.76493131
175mitotic nuclear envelope reassembly (GO:0007084)2.76493131
176metaphase plate congression (GO:0051310)2.76320058
177regulation of spindle organization (GO:0090224)2.75656543
178protein complex localization (GO:0031503)2.75023966
179postreplication repair (GO:0006301)2.74704444
180translation (GO:0006412)2.74295332
181ATP-dependent chromatin remodeling (GO:0043044)2.73470952
182telomere maintenance (GO:0000723)2.72416623
183telomere organization (GO:0032200)2.71458846
184viral mRNA export from host cell nucleus (GO:0046784)2.71021701

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.62863652
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.04200737
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93736045
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.41909116
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10056286
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96832560
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.95741581
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93161158
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82893297
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79953716
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69377238
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60489759
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.58908229
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57655070
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.55272638
16MYC_22102868_ChIP-Seq_BL_Human2.52932932
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42930619
18XRN2_22483619_ChIP-Seq_HELA_Human2.37828592
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35204313
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.31866611
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28924580
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12669974
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05897033
24VDR_23849224_ChIP-Seq_CD4+_Human2.04939095
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04796435
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02291896
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98698648
28CIITA_25753668_ChIP-Seq_RAJI_Human1.94551731
29FOXP3_21729870_ChIP-Seq_TREG_Human1.90536143
30GABP_19822575_ChIP-Seq_HepG2_Human1.88359889
31VDR_21846776_ChIP-Seq_THP-1_Human1.87695296
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.86466176
33AR_21909140_ChIP-Seq_LNCAP_Human1.84297346
34DCP1A_22483619_ChIP-Seq_HELA_Human1.83576301
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.78630440
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74941138
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74818469
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73098412
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70430377
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70094140
41TTF2_22483619_ChIP-Seq_HELA_Human1.69977140
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61013520
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60504991
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56499165
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56473920
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55087222
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53499618
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53011960
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.52928966
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52323636
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52014008
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49004511
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42813705
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42404317
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.39064066
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38331078
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37700787
58KDM5A_27292631_Chip-Seq_BREAST_Human1.37406251
59* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37228472
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36598708
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35729260
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31431903
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.30268908
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29614790
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28284560
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27485454
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23886519
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21508314
69SPI1_23547873_ChIP-Seq_NB4_Human1.20358885
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19442579
71* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18366919
72SCL_19346495_ChIP-Seq_HPC-7_Human1.18220693
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17725390
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17493636
75ZNF274_21170338_ChIP-Seq_K562_Hela1.17394497
76FOXP1_21924763_ChIP-Seq_HESCs_Human1.16409611
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.14901451
78CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13722189
79BCL6_27268052_Chip-Seq_Bcells_Human1.13155941
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10457353
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09906357
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09452880
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08488401
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.06591838
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05994967
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.05677806
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04268300
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04007190
89* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03949559
90TFEB_21752829_ChIP-Seq_HELA_Human1.03917940
91ELK1_19687146_ChIP-ChIP_HELA_Human1.03149319
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02740275
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02462072
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02229691
95UTX_26944678_Chip-Seq_JUKART_Human1.01950082
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01139785
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00383897
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00168721
99* MAF_26560356_Chip-Seq_TH1_Human0.99536200
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97994621
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97921507
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96901935
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96848650
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96753613
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95657426
106TCF7_22412390_ChIP-Seq_EML_Mouse0.95470638
107RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95385946
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93848980
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93596915
110VDR_24763502_ChIP-Seq_THP-1_Human0.93448059
111MAF_26560356_Chip-Seq_TH2_Human0.93183110
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92060410
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91898215
114RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90953499
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90369592
116* MYB_26560356_Chip-Seq_TH2_Human0.89566454
117MYC_18940864_ChIP-ChIP_HL60_Human0.89148079
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87731475
119* MYB_26560356_Chip-Seq_TH1_Human0.87601171
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87485345
121RUNX1_22412390_ChIP-Seq_EML_Mouse0.87213553
122* PHF8_20622854_ChIP-Seq_HELA_Human0.86239944
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86004165
124YY1_22570637_ChIP-Seq_MALME-3M_Human0.85959778
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84436230
126* P68_20966046_ChIP-Seq_HELA_Human0.84238835
127IRF1_19129219_ChIP-ChIP_H3396_Human0.84137659
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81955361
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80525281
130SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80325771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.30026504
2MP0010094_abnormal_chromosome_stability4.14670875
3MP0003111_abnormal_nucleus_morphology3.98425056
4MP0002396_abnormal_hematopoietic_system3.97813426
5MP0004957_abnormal_blastocyst_morpholog3.85693130
6MP0003077_abnormal_cell_cycle3.72040455
7MP0008058_abnormal_DNA_repair3.27023543
8MP0008789_abnormal_olfactory_epithelium3.18416506
9MP0008057_abnormal_DNA_replication3.12003104
10MP0001529_abnormal_vocalization2.98900391
11MP0008007_abnormal_cellular_replicative2.79230274
12MP0009697_abnormal_copulation2.72549091
13MP0005499_abnormal_olfactory_system2.71748129
14MP0005394_taste/olfaction_phenotype2.71748129
15MP0006035_abnormal_mitochondrial_morpho2.17085797
16MP0000350_abnormal_cell_proliferation2.14524092
17MP0008932_abnormal_embryonic_tissue2.14158484
18MP0004808_abnormal_hematopoietic_stem2.13948681
19MP0005084_abnormal_gallbladder_morpholo2.13765452
20MP0000490_abnormal_crypts_of2.12702617
21MP0001730_embryonic_growth_arrest2.07355002
22MP0008877_abnormal_DNA_methylation2.07068547
23MP0003186_abnormal_redox_activity2.05595695
24MP0001545_abnormal_hematopoietic_system2.04212228
25MP0005397_hematopoietic_system_phenotyp2.04212228
26MP0002102_abnormal_ear_morphology1.99329813
27MP0003122_maternal_imprinting1.94276226
28MP0003763_abnormal_thymus_physiology1.87529686
29MP0009333_abnormal_splenocyte_physiolog1.84321488
30MP0003786_premature_aging1.82938843
31MP0006276_abnormal_autonomic_nervous1.81332883
32MP0010352_gastrointestinal_tract_polyps1.73885926
33MP0002163_abnormal_gland_morphology1.66954384
34MP0002398_abnormal_bone_marrow1.64737141
35MP0003123_paternal_imprinting1.63984406
36MP0004147_increased_porphyrin_level1.63075863
37MP0002019_abnormal_tumor_incidence1.60346201
38MP0006054_spinal_hemorrhage1.59800572
39MP0000313_abnormal_cell_death1.54919731
40MP0001929_abnormal_gametogenesis1.54907871
41MP0000049_abnormal_middle_ear1.53710985
42MP0005410_abnormal_fertilization1.53543370
43MP0004142_abnormal_muscle_tone1.51729076
44MP0001697_abnormal_embryo_size1.50011705
45MP0002080_prenatal_lethality1.49452057
46MP0005380_embryogenesis_phenotype1.48741051
47MP0001672_abnormal_embryogenesis/_devel1.48741051
48MP0000703_abnormal_thymus_morphology1.48429084
49MP0002722_abnormal_immune_system1.45705775
50MP0010307_abnormal_tumor_latency1.45035355
51MP0002210_abnormal_sex_determination1.44566568
52MP0003787_abnormal_imprinting1.41421462
53MP0000689_abnormal_spleen_morphology1.41142805
54MP0002736_abnormal_nociception_after1.38063854
55MP0000685_abnormal_immune_system1.36293866
56MP0006072_abnormal_retinal_apoptosis1.36227941
57MP0001905_abnormal_dopamine_level1.35453289
58MP0003984_embryonic_growth_retardation1.33462322
59MP0001293_anophthalmia1.33333012
60MP0002234_abnormal_pharynx_morphology1.33117479
61MP0003880_abnormal_central_pattern1.30351836
62MP0005645_abnormal_hypothalamus_physiol1.30315137
63MP0002088_abnormal_embryonic_growth/wei1.29984010
64MP0001835_abnormal_antigen_presentation1.29910485
65MP0003718_maternal_effect1.29339786
66MP0002085_abnormal_embryonic_tissue1.28332053
67MP0002429_abnormal_blood_cell1.28318508
68MP0000372_irregular_coat_pigmentation1.25491817
69MP0005075_abnormal_melanosome_morpholog1.24810752
70MP0001145_abnormal_male_reproductive1.23932909
71MP0002822_catalepsy1.23375164
72MP0002751_abnormal_autonomic_nervous1.22968792
73MP0008260_abnormal_autophagy1.21543528
74MP0002653_abnormal_ependyma_morphology1.21365418
75MP0000716_abnormal_immune_system1.20521073
76MP0005076_abnormal_cell_differentiation1.19019941
77MP0005174_abnormal_tail_pigmentation1.18829679
78MP0002084_abnormal_developmental_patter1.18762117
79MP0001968_abnormal_touch/_nociception1.13832051
80MP0001853_heart_inflammation1.11597196
81MP0000358_abnormal_cell_content/1.11431893
82MP0002086_abnormal_extraembryonic_tissu1.11221564
83MP0004197_abnormal_fetal_growth/weight/1.10758196
84MP0000653_abnormal_sex_gland1.08110861
85MP0001800_abnormal_humoral_immune1.07931629
86MP0009278_abnormal_bone_marrow1.07777539
87MP0005671_abnormal_response_to1.05889946
88MP0000631_abnormal_neuroendocrine_gland1.04292163
89MP0002420_abnormal_adaptive_immunity1.02868488
90MP0003011_delayed_dark_adaptation1.02776708
91MP0003221_abnormal_cardiomyocyte_apopto1.02191032
92MP0000465_gastrointestinal_hemorrhage1.01307051
93MP0003567_abnormal_fetal_cardiomyocyte1.01080694
94MP0001819_abnormal_immune_cell1.00818456
95MP0005083_abnormal_biliary_tract1.00075159
96MP0003698_abnormal_male_reproductive1.00031956
97MP0001984_abnormal_olfaction0.99757696
98MP0001873_stomach_inflammation0.99200781
99MP0002452_abnormal_antigen_presenting0.95487802
100MP0003656_abnormal_erythrocyte_physiolo0.95229691
101MP0000858_altered_metastatic_potential0.93085899
102MP0000343_altered_response_to0.92530452
103MP0005464_abnormal_platelet_physiology0.91364745
104MP0002405_respiratory_system_inflammati0.90891293
105MP0002723_abnormal_immune_serum0.90712788
106MP0003315_abnormal_perineum_morphology0.89392367
107MP0009672_abnormal_birth_weight0.89119678
108MP0006292_abnormal_olfactory_placode0.88811848
109MP0001764_abnormal_homeostasis0.87548967
110MP0002733_abnormal_thermal_nociception0.85739427
111MP0003121_genomic_imprinting0.84167654
112MP0008995_early_reproductive_senescence0.83337958
113MP0010030_abnormal_orbit_morphology0.82289038
114MP0005025_abnormal_response_to0.82269497
115MP0002132_abnormal_respiratory_system0.81409169
116MP0002161_abnormal_fertility/fecundity0.81246684
117MP0002735_abnormal_chemical_nociception0.79905667
118MP0005384_cellular_phenotype0.79552486
119MP0000477_abnormal_intestine_morphology0.79294165
120MP0004811_abnormal_neuron_physiology0.78910419
121MP0001119_abnormal_female_reproductive0.78350223
122MP0003436_decreased_susceptibility_to0.78112346
123MP0001986_abnormal_taste_sensitivity0.77543365
124MP0003806_abnormal_nucleotide_metabolis0.76727553
125MP0003890_abnormal_embryonic-extraembry0.75589455
126MP0001915_intracranial_hemorrhage0.75152266
127MP0010155_abnormal_intestine_physiology0.73063214
128MP0000015_abnormal_ear_pigmentation0.72807169
129MP0009785_altered_susceptibility_to0.72453153
130MP0005621_abnormal_cell_physiology0.70522331
131MP0008775_abnormal_heart_ventricle0.69697358
132MP0002095_abnormal_skin_pigmentation0.69271935
133MP0002233_abnormal_nose_morphology0.69214742
134MP0002089_abnormal_postnatal_growth/wei0.69026665
135MP0005266_abnormal_metabolism0.68723454
136MP0004133_heterotaxia0.68518217
137MP0003866_abnormal_defecation0.68164054
138MP0006036_abnormal_mitochondrial_physio0.67549507
139MP0009765_abnormal_xenobiotic_induced0.66829071
140MP0005253_abnormal_eye_physiology0.65210749
141MP0008872_abnormal_physiological_respon0.64630519
142MP0002160_abnormal_reproductive_system0.64259763
143MP0002092_abnormal_eye_morphology0.63889491
144MP0002272_abnormal_nervous_system0.63228344
145MP0002837_dystrophic_cardiac_calcinosis0.62719873
146MP0005000_abnormal_immune_tolerance0.61775212
147MP0003699_abnormal_female_reproductive0.60485989
148MP0005646_abnormal_pituitary_gland0.59909728
149MP0001299_abnormal_eye_distance/0.59223625
150MP0002177_abnormal_outer_ear0.58993164

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)5.86316106
2Abnormality of cells of the erythroid lineage (HP:0012130)5.72953675
3Abnormal mitochondria in muscle tissue (HP:0008316)4.71578315
4Acute necrotizing encephalopathy (HP:0006965)4.67505393
5Aplastic anemia (HP:0001915)4.51698731
6Reticulocytopenia (HP:0001896)4.42579777
7Hepatocellular necrosis (HP:0001404)4.34306377
8Mitochondrial inheritance (HP:0001427)4.22994079
9Acute encephalopathy (HP:0006846)4.18808537
10Hepatic necrosis (HP:0002605)4.01612405
11Increased CSF lactate (HP:0002490)3.97451262
12Birth length less than 3rd percentile (HP:0003561)3.70257034
13Selective tooth agenesis (HP:0001592)3.67626838
14Progressive macrocephaly (HP:0004481)3.53397030
15Oral leukoplakia (HP:0002745)3.51359894
16Thrombocytosis (HP:0001894)3.39536448
17Pallor (HP:0000980)3.24053331
18Breast hypoplasia (HP:0003187)3.23469807
19Colon cancer (HP:0003003)3.20452840
203-Methylglutaconic aciduria (HP:0003535)3.18774047
21Abnormality of the anterior horn cell (HP:0006802)3.18740618
22Degeneration of anterior horn cells (HP:0002398)3.18740618
23Carpal bone hypoplasia (HP:0001498)3.16119205
24Increased serum lactate (HP:0002151)3.03549944
25Nasal polyposis (HP:0100582)3.02723712
26Abnormality of the labia minora (HP:0012880)3.01380897
27Lactic acidosis (HP:0003128)2.95899573
28Macrocytic anemia (HP:0001972)2.91438014
29IgM deficiency (HP:0002850)2.88022623
30Cerebral edema (HP:0002181)2.85414173
31Progressive microcephaly (HP:0000253)2.85240739
32Microretrognathia (HP:0000308)2.79730881
33Impulsivity (HP:0100710)2.76988892
34Increased intramyocellular lipid droplets (HP:0012240)2.75381789
35Renal Fanconi syndrome (HP:0001994)2.70518604
36Exercise intolerance (HP:0003546)2.70240172
37Retinal dysplasia (HP:0007973)2.69863369
38Abnormality of the metopic suture (HP:0005556)2.68922439
39Patellar aplasia (HP:0006443)2.64628793
40Opisthotonus (HP:0002179)2.61939930
41Myelodysplasia (HP:0002863)2.61440141
42Abnormality of the nasal mucosa (HP:0000433)2.60473239
43Abnormality of the heme biosynthetic pathway (HP:0010472)2.57905493
44Emotional lability (HP:0000712)2.57399811
45Increased hepatocellular lipid droplets (HP:0006565)2.54823426
46Recurrent bronchitis (HP:0002837)2.53641217
47Prominent metopic ridge (HP:0005487)2.53554906
48Medulloblastoma (HP:0002885)2.50850514
49Increased muscle lipid content (HP:0009058)2.48164238
50Aplasia/Hypoplasia of the patella (HP:0006498)2.47679096
51Abnormal protein glycosylation (HP:0012346)2.46269737
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46269737
53Lipid accumulation in hepatocytes (HP:0006561)2.43551909
54Rough bone trabeculation (HP:0100670)2.42420187
55Respiratory failure (HP:0002878)2.41669550
56Abnormal number of incisors (HP:0011064)2.40865821
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35867124
58Chromsome breakage (HP:0040012)2.35430454
59Methylmalonic aciduria (HP:0012120)2.34623025
60Muscle fiber atrophy (HP:0100295)2.34512014
61Pancytopenia (HP:0001876)2.32219938
62Abnormality of chromosome stability (HP:0003220)2.32044641
63Absent thumb (HP:0009777)2.31475348
6411 pairs of ribs (HP:0000878)2.31467589
65Basal cell carcinoma (HP:0002671)2.30342954
66Petechiae (HP:0000967)2.29640797
67CNS hypomyelination (HP:0003429)2.29454160
68Microvesicular hepatic steatosis (HP:0001414)2.28104887
69Meckel diverticulum (HP:0002245)2.27697776
70Nephrogenic diabetes insipidus (HP:0009806)2.27335334
71Increased nuchal translucency (HP:0010880)2.27063123
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25481711
73Abnormality of T cell physiology (HP:0011840)2.22747415
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.22541943
75Chronic otitis media (HP:0000389)2.21566507
76Exertional dyspnea (HP:0002875)2.21154744
77Abnormal spermatogenesis (HP:0008669)2.20972745
78Neoplasm of the pancreas (HP:0002894)2.20459902
79Bone marrow hypocellularity (HP:0005528)2.19961980
80Medial flaring of the eyebrow (HP:0010747)2.19578272
81Severe combined immunodeficiency (HP:0004430)2.18299426
82Abnormality of the ileum (HP:0001549)2.17638784
83Dicarboxylic aciduria (HP:0003215)2.16459422
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16459422
85Abnormality of the preputium (HP:0100587)2.16274645
86Agnosia (HP:0010524)2.15539844
87Cleft eyelid (HP:0000625)2.15208911
88Congenital primary aphakia (HP:0007707)2.15032167
89Premature graying of hair (HP:0002216)2.14790950
90Abnormality of reticulocytes (HP:0004312)2.14614009
91Lissencephaly (HP:0001339)2.13361339
92Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13060978
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13060978
94Short 4th metacarpal (HP:0010044)2.12565817
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12565817
96Optic disc pallor (HP:0000543)2.12530788
97Broad distal phalanx of finger (HP:0009836)2.11396051
98Hyperglycinemia (HP:0002154)2.11188080
99Type I transferrin isoform profile (HP:0003642)2.10595545
100Duodenal stenosis (HP:0100867)2.09688658
101Small intestinal stenosis (HP:0012848)2.09688658
102Gait imbalance (HP:0002141)2.09310982
103Elevated erythrocyte sedimentation rate (HP:0003565)2.09045204
104Premature ovarian failure (HP:0008209)2.08993537
105CNS demyelination (HP:0007305)2.08247766
106Bronchitis (HP:0012387)2.07974218
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07302410
108Abnormality of lateral ventricle (HP:0030047)2.05963001
109Delayed CNS myelination (HP:0002188)2.05320472
110Optic nerve coloboma (HP:0000588)2.04650255
111Cellular immunodeficiency (HP:0005374)2.04158448
112Pulmonary fibrosis (HP:0002206)2.03197379
113Ependymoma (HP:0002888)2.02931832
114Atrophy/Degeneration involving motor neurons (HP:0007373)2.02365559
115Lymphoma (HP:0002665)2.01272322
116Acute lymphatic leukemia (HP:0006721)2.00060119
117Multiple enchondromatosis (HP:0005701)1.99005449
118Prominent nose (HP:0000448)1.97253981
119Polyphagia (HP:0002591)1.95015093
120Lethargy (HP:0001254)1.94973286
121Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94709164
122Recurrent viral infections (HP:0004429)1.94601126
123Tracheoesophageal fistula (HP:0002575)1.93138630
124Overlapping toe (HP:0001845)1.93005325
125Poikiloderma (HP:0001029)1.92919816
126Abnormality of T cells (HP:0002843)1.92849527
127Atresia of the external auditory canal (HP:0000413)1.92538066
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92206189
129Sloping forehead (HP:0000340)1.91635203
130High pitched voice (HP:0001620)1.91125717
131Cerebral palsy (HP:0100021)1.90461032
132Progressive muscle weakness (HP:0003323)1.89308005
133Panhypogammaglobulinemia (HP:0003139)1.88112428
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87918283
135Delusions (HP:0000746)1.87404437
136Combined immunodeficiency (HP:0005387)1.87181216
137Failure to thrive in infancy (HP:0001531)1.86527880
138Abnormality of cells of the lymphoid lineage (HP:0012140)1.85794838
139Upper limb muscle weakness (HP:0003484)1.84578023
140B lymphocytopenia (HP:0010976)1.84416321
141Poor head control (HP:0002421)1.84016111
142Type 2 muscle fiber atrophy (HP:0003554)1.83497198
143Cerebral hypomyelination (HP:0006808)1.83436762
144Secondary amenorrhea (HP:0000869)1.83159640
145Increased serum pyruvate (HP:0003542)1.82152930
146Cortical dysplasia (HP:0002539)1.82090375
147Generalized aminoaciduria (HP:0002909)1.81817204
148Trismus (HP:0000211)1.81097532
149Abnormality of the fingertips (HP:0001211)1.80874089
150Severe visual impairment (HP:0001141)1.79652284
151Abnormality of glycolysis (HP:0004366)1.79451202
152Sclerocornea (HP:0000647)1.78299970
153Abnormal lung lobation (HP:0002101)1.78195696
154Leukopenia (HP:0001882)1.77936562
155Lymphopenia (HP:0001888)1.77553728
156Amaurosis fugax (HP:0100576)1.76183215
157Unsteady gait (HP:0002317)1.74615106
158Pachygyria (HP:0001302)1.74606398
159Respiratory difficulties (HP:0002880)1.73840680
160Slender long bone (HP:0003100)1.73833811
161Ectopic kidney (HP:0000086)1.73813531
162Testicular atrophy (HP:0000029)1.73750589
163Hyperacusis (HP:0010780)1.71874891
164Abnormal glycosylation (HP:0012345)1.71674985
165Abnormal protein N-linked glycosylation (HP:0012347)1.71674985
166Prolonged bleeding time (HP:0003010)1.67934383
167Horseshoe kidney (HP:0000085)1.66802153
168Gliosis (HP:0002171)1.64946264
169Abnormality of midbrain morphology (HP:0002418)1.61267828
170Molar tooth sign on MRI (HP:0002419)1.61267828
171Pancreatic cysts (HP:0001737)1.61152952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.77668872
2BUB14.75147490
3MAP4K24.02041237
4WEE13.87025059
5CDC73.35702030
6EEF2K2.88911988
7NEK22.86566645
8MAP3K102.72800269
9TRIM282.47296856
10DYRK32.35286842
11MAP4K12.22690530
12NME22.17652101
13EIF2AK12.10911736
14EIF2AK32.08689919
15CSNK1G32.07841119
16STK161.90203983
17MAP2K71.89750776
18ACVR1B1.79767841
19TESK21.76823947
20RPS6KA41.76279168
21ARAF1.76188050
22NUAK11.71368564
23BRSK21.71149231
24CDK71.70358599
25TTK1.69759132
26CSNK1A1L1.69197165
27LIMK11.68287383
28PLK41.66454809
29DYRK21.61383390
30CSNK1G21.61128130
31SRPK11.59416995
32TSSK61.58903956
33PASK1.58386071
34CDK41.56957092
35ATR1.54558295
36PLK11.52818995
37RPS6KB21.50056091
38STK101.47732721
39SCYL21.47351599
40KIT1.42441295
41CDK121.41706122
42TGFBR11.41429724
43CSNK1G11.40670230
44PIM21.37773051
45VRK11.35317757
46NEK11.29431377
47TIE11.27884962
48FLT31.24956882
49AURKB1.21407083
50CCNB11.20788470
51MAPK131.20769218
52MAP3K81.20580859
53BRSK11.19154715
54BCR1.18365543
55LRRK21.17526923
56DAPK11.16645171
57BTK1.16299670
58KDR1.16011260
59CSF1R1.15217229
60TESK11.14162662
61PAK41.13767753
62ZAK1.10729943
63MAP3K41.10665343
64MKNK11.10020933
65TLK11.08086336
66CHEK21.04118941
67CDK81.01210609
68CHEK10.98797701
69ERN10.97031315
70ZAP700.89783774
71PIM10.88706089
72AURKA0.86650595
73BLK0.86477454
74WNK30.85541156
75CDK190.83670301
76PDK40.82757327
77PDK30.82757327
78STK40.81834293
79MAP3K110.81092178
80MKNK20.80285605
81TAOK10.77738114
82BCKDK0.77544254
83ICK0.74237885
84PKN20.71852260
85MAPKAPK30.71701759
86CDK140.70638209
87MINK10.70295183
88TEC0.69560400
89CDK20.69304286
90GRK60.67034648
91TRIB30.66340428
92BRD40.64804129
93PAK10.62648647
94ATM0.61418396
95TYK20.61311872
96ABL20.61178337
97CSNK2A20.60823765
98PLK30.60819986
99NLK0.60453714
100MTOR0.59504253
101PBK0.58416065
102PDK20.57864039
103CDK11A0.57654108
104ALK0.56933795
105TAF10.55428351
106JAK30.54721744
107CDK180.54281136
108MAP2K30.54230552
109MARK10.52870362
110CSNK2A10.50981878
111CDK150.49996251
112TBK10.49751440
113RPS6KA50.49650557
114CDK60.47918231
115NME10.47728546
116LMTK20.46601836
117SYK0.44803252
118GRK50.44396146
119TAOK20.43044668
120CDK10.42325335
121BRAF0.42162080
122SIK30.41923450
123AKT20.40778302
124PTK2B0.38654311
125TNK20.37964709
126TAOK30.36671626
127CSNK1A10.36115326
128RAF10.35620212
129LYN0.34780441
130IKBKB0.34198612
131EPHA20.34195898
132MATK0.33382212
133CHUK0.32587830
134GRK70.32442040
135FES0.31404188
136ADRBK10.31379737
137ILK0.30974377
138PAK60.30659028
139PAK20.29762719
140EIF2AK20.29359143
141CLK10.26836428
142DAPK30.26270228
143PINK10.23833744
144MAP2K40.22622124
145MAPKAPK50.22080241
146PRKCG0.21636424

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.23958318
2Mismatch repair_Homo sapiens_hsa034303.85806006
3Ribosome_Homo sapiens_hsa030103.69748389
4Base excision repair_Homo sapiens_hsa034103.36504036
5Oxidative phosphorylation_Homo sapiens_hsa001903.29143245
6Spliceosome_Homo sapiens_hsa030403.26401934
7Parkinsons disease_Homo sapiens_hsa050123.18878888
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12300311
9Homologous recombination_Homo sapiens_hsa034402.96822637
10RNA transport_Homo sapiens_hsa030132.88136585
11RNA polymerase_Homo sapiens_hsa030202.75403469
12Pyrimidine metabolism_Homo sapiens_hsa002402.67666288
13Proteasome_Homo sapiens_hsa030502.60686325
14Cell cycle_Homo sapiens_hsa041102.57575751
15Nucleotide excision repair_Homo sapiens_hsa034202.43294628
16One carbon pool by folate_Homo sapiens_hsa006702.35882928
17Non-homologous end-joining_Homo sapiens_hsa034502.32025082
18Huntingtons disease_Homo sapiens_hsa050162.21218893
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14326898
20Fanconi anemia pathway_Homo sapiens_hsa034601.85916910
21Fatty acid elongation_Homo sapiens_hsa000621.82775875
22RNA degradation_Homo sapiens_hsa030181.78750997
23Alzheimers disease_Homo sapiens_hsa050101.74342136
24Basal transcription factors_Homo sapiens_hsa030221.70383031
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60952471
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60246324
27mRNA surveillance pathway_Homo sapiens_hsa030151.54211931
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50357135
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49329780
30p53 signaling pathway_Homo sapiens_hsa041151.38884117
31Pentose phosphate pathway_Homo sapiens_hsa000301.37037568
32Purine metabolism_Homo sapiens_hsa002301.33481439
33Antigen processing and presentation_Homo sapiens_hsa046121.29145113
34Herpes simplex infection_Homo sapiens_hsa051681.20601155
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20562716
36Epstein-Barr virus infection_Homo sapiens_hsa051691.19489856
37Sulfur relay system_Homo sapiens_hsa041221.15538322
38Primary immunodeficiency_Homo sapiens_hsa053401.15205766
39Regulation of autophagy_Homo sapiens_hsa041401.13601862
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13120572
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10079094
42Folate biosynthesis_Homo sapiens_hsa007901.06414851
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03256015
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.01103749
45N-Glycan biosynthesis_Homo sapiens_hsa005101.00094591
46Selenocompound metabolism_Homo sapiens_hsa004500.97677793
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.97135857
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.88089057
49Viral carcinogenesis_Homo sapiens_hsa052030.86779064
50Biosynthesis of amino acids_Homo sapiens_hsa012300.86778646
51Collecting duct acid secretion_Homo sapiens_hsa049660.84339490
52HTLV-I infection_Homo sapiens_hsa051660.83959525
53Thyroid cancer_Homo sapiens_hsa052160.81522057
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81431630
55Metabolic pathways_Homo sapiens_hsa011000.80636292
56Cardiac muscle contraction_Homo sapiens_hsa042600.78272396
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77875367
58Legionellosis_Homo sapiens_hsa051340.76749149
59Oocyte meiosis_Homo sapiens_hsa041140.76557711
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76548259
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72691024
62Systemic lupus erythematosus_Homo sapiens_hsa053220.71381918
63Peroxisome_Homo sapiens_hsa041460.70707434
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70032632
65Acute myeloid leukemia_Homo sapiens_hsa052210.69631667
66Steroid biosynthesis_Homo sapiens_hsa001000.69285406
67Shigellosis_Homo sapiens_hsa051310.66802399
68Notch signaling pathway_Homo sapiens_hsa043300.66282698
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64102225
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63725313
71Measles_Homo sapiens_hsa051620.62643532
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62314506
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61370018
74Pyruvate metabolism_Homo sapiens_hsa006200.60883211
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59597838
76Propanoate metabolism_Homo sapiens_hsa006400.58630540
77Hepatitis B_Homo sapiens_hsa051610.58422165
78Apoptosis_Homo sapiens_hsa042100.56621361
79Butanoate metabolism_Homo sapiens_hsa006500.56594025
80Chronic myeloid leukemia_Homo sapiens_hsa052200.56469014
81Small cell lung cancer_Homo sapiens_hsa052220.56162524
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54849717
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53957065
84Vibrio cholerae infection_Homo sapiens_hsa051100.52511717
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52248552
86B cell receptor signaling pathway_Homo sapiens_hsa046620.51142059
87Colorectal cancer_Homo sapiens_hsa052100.50535815
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50412329
89Fatty acid metabolism_Homo sapiens_hsa012120.50054585
90Vitamin B6 metabolism_Homo sapiens_hsa007500.49925276
91Sulfur metabolism_Homo sapiens_hsa009200.49758159
92Carbon metabolism_Homo sapiens_hsa012000.49132936
93Influenza A_Homo sapiens_hsa051640.46980234
94Synaptic vesicle cycle_Homo sapiens_hsa047210.46155750
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.45176265
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44847785
97Arachidonic acid metabolism_Homo sapiens_hsa005900.42389234
98MicroRNAs in cancer_Homo sapiens_hsa052060.41245531
99Hematopoietic cell lineage_Homo sapiens_hsa046400.41168229
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40373011
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.40093268
102Leishmaniasis_Homo sapiens_hsa051400.39753953
103Protein export_Homo sapiens_hsa030600.38532189
104Glutathione metabolism_Homo sapiens_hsa004800.37784734
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37018623
106Alcoholism_Homo sapiens_hsa050340.34523371
107Phototransduction_Homo sapiens_hsa047440.33916300
108Non-small cell lung cancer_Homo sapiens_hsa052230.32926095
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32920003
110Renin-angiotensin system_Homo sapiens_hsa046140.32582213
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32035759
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31837571
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29777977
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.29546043
115Other glycan degradation_Homo sapiens_hsa005110.28116699
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.27805704
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27659758
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27306275
119Galactose metabolism_Homo sapiens_hsa000520.27292356
120HIF-1 signaling pathway_Homo sapiens_hsa040660.26620535
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26571578
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.26429961
123Basal cell carcinoma_Homo sapiens_hsa052170.26155296
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25282788
125Lysine degradation_Homo sapiens_hsa003100.24742068
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24340041
127Fructose and mannose metabolism_Homo sapiens_hsa000510.24144204
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23843152
129Pancreatic cancer_Homo sapiens_hsa052120.22036438
130Viral myocarditis_Homo sapiens_hsa054160.21726792
131Bladder cancer_Homo sapiens_hsa052190.21527772
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20730246
133mTOR signaling pathway_Homo sapiens_hsa041500.20162802
134Toxoplasmosis_Homo sapiens_hsa051450.19685033
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.18583119
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16911960
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16471721
138Phagosome_Homo sapiens_hsa041450.16055201
139Asthma_Homo sapiens_hsa053100.08876083
140Nicotine addiction_Homo sapiens_hsa050330.08714859
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05537532
142beta-Alanine metabolism_Homo sapiens_hsa004100.03805373

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