TMEM40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.20179678
2viral transcription (GO:0019083)7.40654135
3protein neddylation (GO:0045116)7.24217023
4translational termination (GO:0006415)7.10672489
5ribosomal small subunit biogenesis (GO:0042274)6.48068263
6maturation of SSU-rRNA (GO:0030490)6.20195817
7translational elongation (GO:0006414)6.18249045
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.01939704
9cotranslational protein targeting to membrane (GO:0006613)5.86801410
10protein targeting to ER (GO:0045047)5.86323334
11hemidesmosome assembly (GO:0031581)5.76533722
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.59420296
13protein localization to endoplasmic reticulum (GO:0070972)5.54023867
14neutrophil activation involved in immune response (GO:0002283)5.51118468
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.49834536
16viral life cycle (GO:0019058)5.47675147
17cellular protein complex disassembly (GO:0043624)5.33902868
18DNA deamination (GO:0045006)5.32462314
19definitive hemopoiesis (GO:0060216)5.27402119
20regulation of water loss via skin (GO:0033561)5.25155635
21translational initiation (GO:0006413)5.05277603
22desmosome organization (GO:0002934)5.00223838
23platelet dense granule organization (GO:0060155)4.97816890
24G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.83885871
25purinergic nucleotide receptor signaling pathway (GO:0035590)4.78391656
26protein complex disassembly (GO:0043241)4.71490117
27lipoxygenase pathway (GO:0019372)4.62452385
28regulation of integrin-mediated signaling pathway (GO:2001044)4.36142297
29macromolecular complex disassembly (GO:0032984)4.35587547
30regulation of platelet aggregation (GO:0090330)4.32753490
31ribosomal large subunit biogenesis (GO:0042273)4.30799907
32negative regulation of protein localization to cell surface (GO:2000009)4.30167077
33leukocyte migration involved in inflammatory response (GO:0002523)4.24057556
34positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.19858902
35long-chain fatty acid biosynthetic process (GO:0042759)4.17167571
36regulation of platelet activation (GO:0010543)4.16084473
37negative regulation of erythrocyte differentiation (GO:0045647)4.14547593
38nuclear-transcribed mRNA catabolic process (GO:0000956)4.14196574
39negative regulation of heart rate (GO:0010459)4.07343599
40phosphatidylinositol acyl-chain remodeling (GO:0036149)4.02232817
41keratinocyte development (GO:0003334)3.98720140
42mRNA catabolic process (GO:0006402)3.97624361
43telomere maintenance via semi-conservative replication (GO:0032201)3.97354516
44negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.96100882
45negative regulation of thymocyte apoptotic process (GO:0070244)3.95783403
46antigen processing and presentation via MHC class Ib (GO:0002475)3.92055365
47megakaryocyte development (GO:0035855)3.91521326
48blood coagulation, intrinsic pathway (GO:0007597)3.88707048
49protein targeting to membrane (GO:0006612)3.87873434
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.87073249
51fusion of sperm to egg plasma membrane (GO:0007342)3.84642782
52negative regulation of platelet activation (GO:0010544)3.84411972
53lymphoid progenitor cell differentiation (GO:0002320)3.77796907
54ribonucleoprotein complex biogenesis (GO:0022613)3.72677861
55RNA catabolic process (GO:0006401)3.72076347
56positive regulation of cAMP-mediated signaling (GO:0043950)3.69221686
57fatty acid elongation (GO:0030497)3.64871936
58purinergic receptor signaling pathway (GO:0035587)3.62931889
59angiogenesis involved in wound healing (GO:0060055)3.61156800
60negative regulation of homotypic cell-cell adhesion (GO:0034111)3.60451856
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59694204
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59694204
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.58541322
64positive regulation of endothelial cell differentiation (GO:0045603)3.58501826
65DNA strand elongation involved in DNA replication (GO:0006271)3.56717822
66positive regulation of mast cell activation (GO:0033005)3.55970725
67autophagic vacuole fusion (GO:0000046)3.55036402
68response to interferon-beta (GO:0035456)3.53621350
69adenosine receptor signaling pathway (GO:0001973)3.51802000
70DNA strand elongation (GO:0022616)3.51616932
71negative regulation of appetite (GO:0032099)3.50235740
72negative regulation of response to food (GO:0032096)3.50235740
73neutrophil activation (GO:0042119)3.48608447
74translation (GO:0006412)3.46277828
75regulation of lipoprotein metabolic process (GO:0050746)3.44962284
76pseudouridine synthesis (GO:0001522)3.43532426
77endosome to melanosome transport (GO:0035646)3.35290979
78endosome to pigment granule transport (GO:0043485)3.35290979
79phosphatidylserine acyl-chain remodeling (GO:0036150)3.33739378
80keratinocyte proliferation (GO:0043616)3.30748005
81keratinocyte differentiation (GO:0030216)3.28880728
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27390628
83negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.24291397
84telomere maintenance via recombination (GO:0000722)3.24035244
85platelet aggregation (GO:0070527)3.22940827
86negative regulation of norepinephrine secretion (GO:0010700)3.21897543
87formation of translation preinitiation complex (GO:0001731)3.20957558
88dopamine transport (GO:0015872)3.18171886
89secretory granule organization (GO:0033363)3.15648804
90multicellular organismal water homeostasis (GO:0050891)3.14698030
91regulation of memory T cell differentiation (GO:0043380)3.14666660
92response to interferon-alpha (GO:0035455)3.13451202
93rRNA processing (GO:0006364)3.12665230
94adenosine metabolic process (GO:0046085)3.11477988
95G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.08635890
96phospholipid scrambling (GO:0017121)3.08246560
97bundle of His cell to Purkinje myocyte communication (GO:0086069)3.06696202
98pyrimidine nucleoside catabolic process (GO:0046135)3.06310330
99mitochondrial calcium ion transport (GO:0006851)3.05350203
100granulocyte activation (GO:0036230)3.04168083
101keratinization (GO:0031424)3.03150306
102polyketide metabolic process (GO:0030638)3.03105994
103doxorubicin metabolic process (GO:0044598)3.03105994
104daunorubicin metabolic process (GO:0044597)3.03105994
105rRNA metabolic process (GO:0016072)3.00449553
106negative regulation of calcium ion transport into cytosol (GO:0010523)2.98887330
107phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.98118390
108regulation of integrin activation (GO:0033623)2.97736177
109embryonic hemopoiesis (GO:0035162)2.97076272
110DNA replication initiation (GO:0006270)2.93861179
111regulation of Golgi to plasma membrane protein transport (GO:0042996)2.92456616
112mesodermal cell differentiation (GO:0048333)2.91156055
113water homeostasis (GO:0030104)2.90852946
114skeletal muscle tissue regeneration (GO:0043403)2.90841569
115cellular biogenic amine catabolic process (GO:0042402)2.90625188
116amine catabolic process (GO:0009310)2.90625188
117negative regulation of keratinocyte proliferation (GO:0010839)2.89234861
118regulation of erythrocyte differentiation (GO:0045646)2.89074689
119telomere maintenance via telomere lengthening (GO:0010833)2.88750363
120mitotic recombination (GO:0006312)2.85279769
121cellular component biogenesis (GO:0044085)2.83319473
122positive regulation of B cell differentiation (GO:0045579)2.83033270
123peptide cross-linking (GO:0018149)2.82500236
124termination of G-protein coupled receptor signaling pathway (GO:0038032)2.82326475
125molting cycle (GO:0042303)2.82257322
126hair cycle (GO:0042633)2.82257322
127thrombin receptor signaling pathway (GO:0070493)2.80837299
128positive regulation of gamma-delta T cell activation (GO:0046645)2.80649726
129tRNA methylation (GO:0030488)2.78065169
130multicellular organism reproduction (GO:0032504)2.77606364
131regulation of MHC class II biosynthetic process (GO:0045346)2.77100966
132plasma membrane fusion (GO:0045026)2.77021532
133antigen processing and presentation of endogenous antigen (GO:0019883)2.76974939
134termination of signal transduction (GO:0023021)2.76688787
135L-fucose metabolic process (GO:0042354)2.76594759
136L-fucose catabolic process (GO:0042355)2.76594759
137fucose catabolic process (GO:0019317)2.76594759
138organelle membrane fusion (GO:0090174)2.75815512
139polyamine biosynthetic process (GO:0006596)2.74804745
140regulation of cilium movement (GO:0003352)2.73456637
141DNA unwinding involved in DNA replication (GO:0006268)2.71746823
142regulation of endothelial cell differentiation (GO:0045601)2.71524462
1433-UTR-mediated mRNA stabilization (GO:0070935)2.68793629
144purine-containing compound salvage (GO:0043101)2.68572140
145response to protozoan (GO:0001562)2.66951205
146nucleotide-excision repair, DNA gap filling (GO:0006297)2.66365441
147epidermis development (GO:0008544)2.65959006
148phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.65451258
149regulation of macrophage derived foam cell differentiation (GO:0010743)2.65104721
150superoxide anion generation (GO:0042554)2.64033360
151establishment of protein localization to membrane (GO:0090150)2.63986680
152mast cell activation (GO:0045576)2.63238177
153defense response to protozoan (GO:0042832)2.59895252
154phospholipid homeostasis (GO:0055091)2.59201856
155regulation of protein localization to cell surface (GO:2000008)2.58945254
156somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58537226
157isotype switching (GO:0045190)2.58537226
158somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58537226
159phosphatidylcholine acyl-chain remodeling (GO:0036151)2.57768843
160low-density lipoprotein particle remodeling (GO:0034374)2.57476195
161regulation of homotypic cell-cell adhesion (GO:0034110)2.56982368
162high-density lipoprotein particle remodeling (GO:0034375)2.56365025
163hepatocyte apoptotic process (GO:0097284)2.55670265
164establishment of skin barrier (GO:0061436)2.55219428
165mitochondrial calcium ion homeostasis (GO:0051560)2.55164683
166regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.54673355
167mature B cell differentiation involved in immune response (GO:0002313)2.53235706
168negative regulation of RNA splicing (GO:0033119)2.53050040
169CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.52860829
170leukocyte degranulation (GO:0043299)2.50752422
171negative regulation of T cell apoptotic process (GO:0070233)2.50355002
172myeloid cell development (GO:0061515)2.49851184
173ribosome biogenesis (GO:0042254)2.49698388
174positive regulation of protein homodimerization activity (GO:0090073)2.49602497
175regulation of mast cell activation (GO:0033003)2.48634335
176iron-sulfur cluster assembly (GO:0016226)2.48325457
177metallo-sulfur cluster assembly (GO:0031163)2.48325457
178regulation of transmission of nerve impulse (GO:0051969)2.48244400
179platelet degranulation (GO:0002576)2.48210472
180regulation of keratinocyte proliferation (GO:0010837)2.48136096
181vesicle targeting (GO:0006903)2.47408338
182T cell homeostasis (GO:0043029)2.47236295
183erythrocyte maturation (GO:0043249)2.45193785
184IMP biosynthetic process (GO:0006188)2.43434283
185exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43329599
186IMP metabolic process (GO:0046040)2.42732550
187mast cell activation involved in immune response (GO:0002279)2.40218545
188mast cell degranulation (GO:0043303)2.40218545
189positive regulation of granulocyte differentiation (GO:0030854)2.39003093
190ncRNA 3-end processing (GO:0043628)2.38891915
191protein targeting (GO:0006605)2.38440609
192establishment of protein localization to organelle (GO:0072594)2.37354282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.33665499
2SCL_19346495_ChIP-Seq_HPC-7_Human4.04402806
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77941814
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.64420128
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.91323495
6* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.86139206
7* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.82939613
8TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.79187752
9GBX2_23144817_ChIP-Seq_PC3_Human2.70058162
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.68815970
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61090249
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.53606134
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53248239
14VDR_22108803_ChIP-Seq_LS180_Human2.50650954
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46231558
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35898920
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34750316
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.31657226
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24755060
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.14792692
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11390864
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.08384114
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07078315
24VDR_21846776_ChIP-Seq_THP-1_Human2.06643836
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05636186
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03907096
27IRF8_22096565_ChIP-ChIP_GC-B_Human2.03113514
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03034581
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02627164
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01737788
31TAF15_26573619_Chip-Seq_HEK293_Human2.01624460
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.01604335
33GABP_17652178_ChIP-ChIP_JURKAT_Human2.00105758
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98960801
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.98339016
36GATA1_22025678_ChIP-Seq_K562_Human1.96790593
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96454331
38ERG_20887958_ChIP-Seq_HPC-7_Mouse1.94689421
39SPI1_23547873_ChIP-Seq_NB4_Human1.94614972
40XRN2_22483619_ChIP-Seq_HELA_Human1.94374670
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92357388
42VDR_23849224_ChIP-Seq_CD4+_Human1.91796918
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90499080
44MYC_22102868_ChIP-Seq_BL_Human1.88838565
45FOXP3_21729870_ChIP-Seq_TREG_Human1.84980451
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.84555556
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.84224812
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76794601
49* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.75359639
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71914224
51* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.69623247
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69053398
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65414067
54* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.64497957
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.64492346
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63454070
57* HTT_18923047_ChIP-ChIP_STHdh_Human1.62193782
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.59376833
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.58222264
60* TP63_23658742_ChIP-Seq_EP156T_Human1.58180860
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53107253
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52243655
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52178022
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50699386
65GATA2_19941826_ChIP-Seq_K562_Human1.50106333
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.49536079
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.49536079
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48894823
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48740224
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.47705467
71ELK4_26923725_Chip-Seq_MESODERM_Mouse1.47289188
72GATA4_25053715_ChIP-Seq_YYC3_Human1.47134471
73TTF2_22483619_ChIP-Seq_HELA_Human1.47056842
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46196464
75SOX2_20726797_ChIP-Seq_SW620_Human1.45572484
76EZH2_22144423_ChIP-Seq_EOC_Human1.45474686
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45195943
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43872085
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43810367
80GATA1_19941826_ChIP-Seq_K562_Human1.42605976
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.41564289
82BCAT_22108803_ChIP-Seq_LS180_Human1.39963875
83* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39904828
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37634271
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.37310599
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37310599
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37237818
88AR_25329375_ChIP-Seq_VCAP_Human1.36670856
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35913130
90AR_20517297_ChIP-Seq_VCAP_Human1.35795410
91* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35590036
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33684166
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33276064
94ZNF274_21170338_ChIP-Seq_K562_Hela1.33249005
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33239149
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33239149
97DCP1A_22483619_ChIP-Seq_HELA_Human1.33128741
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33112189
99IGF1R_20145208_ChIP-Seq_DFB_Human1.32277153
100VDR_24763502_ChIP-Seq_THP-1_Human1.31454767
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31073994
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30502303
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.30367790
104SMAD4_21799915_ChIP-Seq_A2780_Human1.30298674
105ER_23166858_ChIP-Seq_MCF-7_Human1.30187455
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29645298
107GABP_19822575_ChIP-Seq_HepG2_Human1.29306623
108STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28096354
109MYB_26560356_Chip-Seq_TH2_Human1.27583676
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27464362
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27141830
112MAF_26560356_Chip-Seq_TH1_Human1.26254688
113CIITA_25753668_ChIP-Seq_RAJI_Human1.25968904
114* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25931789
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25836292
116ELK1_19687146_ChIP-ChIP_HELA_Human1.23442728
117SOX2_19829295_ChIP-Seq_ESCs_Human1.23255854
118NANOG_19829295_ChIP-Seq_ESCs_Human1.23255854
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23217018
120UTX_26944678_Chip-Seq_JUKART_Human1.23069156
121* RBPJ_21746931_ChIP-Seq_IB4_Human1.22589672
122* TCF7_22412390_ChIP-Seq_EML_Mouse1.22415755
123E2F1_21310950_ChIP-Seq_MCF-7_Human1.21395298
124EWS_26573619_Chip-Seq_HEK293_Human1.20971896
125TP53_16413492_ChIP-PET_HCT116_Human1.20355738
126GATA6_21074721_ChIP-Seq_CACO-2_Human1.19442657
127ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17957189
128GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17667016
129ERG_20517297_ChIP-Seq_VCAP_Human1.17059377
130SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16609623
131IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15903713
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15732325
133* NANOG_20526341_ChIP-Seq_ESCs_Human1.15439428
134CJUN_26792858_Chip-Seq_BT549_Human1.15331336
135STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15300361
136BP1_19119308_ChIP-ChIP_Hs578T_Human1.15050387
137TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14722311
138IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13948979
139MYB_26560356_Chip-Seq_TH1_Human1.13896048
140GATA1_19941827_ChIP-Seq_MEL_Mouse1.13588955
141TCF4_18268006_ChIP-ChIP_LS174T_Human1.13505283
142CDX2_22108803_ChIP-Seq_LS180_Human1.12954444
143THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12764086
144FOXO3_23340844_ChIP-Seq_DLD1_Human1.12016804
145GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.11450362
146FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10401922
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09757049
148OCT1_27270436_Chip-Seq_PROSTATE_Human1.09218985
149GATA3_26560356_Chip-Seq_TH2_Human1.08170680
150MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07964399
151P300_19829295_ChIP-Seq_ESCs_Human1.07903189
152ARNT_22903824_ChIP-Seq_MCF-7_Human1.07501026
153FOXM1_23109430_ChIP-Seq_U2OS_Human1.06800023
154ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06001210
155STAT3_23295773_ChIP-Seq_U87_Human1.05992649
156CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04977192
157* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04339103
158HOXB7_26014856_ChIP-Seq_BT474_Human1.04082579
159HNFA_21074721_ChIP-Seq_CACO-2_Human1.04022182
160E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03920353
161* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03720933
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03306466
163PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03205443
164PHF8_20622853_ChIP-Seq_HELA_Human1.03104784
165ETV1_20927104_ChIP-Seq_GIST48_Human1.03019686
166TCF4_22108803_ChIP-Seq_LS180_Human1.02331038
167NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02003645
168CEBPB_22108803_ChIP-Seq_LS180_Human1.01895329
169IRF8_21731497_ChIP-ChIP_J774_Mouse1.01058829
170* ETS1_22383799_ChIP-Seq_G1ME_Mouse1.00525748
171TCF4_23295773_ChIP-Seq_U87_Human1.00406599
172ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00328168
173* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99858932
174CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99706874
175PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99511679
176MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99269946
177TBL1_22424771_ChIP-Seq_293T_Human0.98541558
178ZNF263_19887448_ChIP-Seq_K562_Human0.96544624
179PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96460844
180MAF_26560356_Chip-Seq_TH2_Human0.95008536
181TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94232538
182CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93757295
183POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93225914
184BCL6_27268052_Chip-Seq_Bcells_Human0.92647473
185MYC_18940864_ChIP-ChIP_HL60_Human0.92479098
186* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92120539
187YY1_21170310_ChIP-Seq_MESCs_Mouse0.91580554
188ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90998801
189PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90935534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.99500978
2MP0004808_abnormal_hematopoietic_stem3.19572383
3MP0008004_abnormal_stomach_pH3.16291205
4MP0000465_gastrointestinal_hemorrhage3.03869172
5MP0005397_hematopoietic_system_phenotyp2.96441957
6MP0001545_abnormal_hematopoietic_system2.96441957
7MP0010678_abnormal_skin_adnexa2.90400776
8MP0005464_abnormal_platelet_physiology2.89499764
9MP0005075_abnormal_melanosome_morpholog2.78040886
10MP0004147_increased_porphyrin_level2.72626367
11MP0009379_abnormal_foot_pigmentation2.63617464
12MP0005174_abnormal_tail_pigmentation2.61044644
13MP0002796_impaired_skin_barrier2.54451789
14MP0002736_abnormal_nociception_after2.34403120
15MP0001835_abnormal_antigen_presentation2.25118261
16MP0002095_abnormal_skin_pigmentation2.20563379
17MP0000490_abnormal_crypts_of2.13465203
18MP0005083_abnormal_biliary_tract2.10960153
19MP0005501_abnormal_skin_physiology2.07814723
20MP0009785_altered_susceptibility_to2.00991014
21MP0000427_abnormal_hair_cycle1.99994051
22MP0003763_abnormal_thymus_physiology1.99390114
23MP0008872_abnormal_physiological_respon1.98356505
24MP0003806_abnormal_nucleotide_metabolis1.97560946
25MP0003693_abnormal_embryo_hatching1.92595474
26MP0002398_abnormal_bone_marrow1.92357418
27MP0010094_abnormal_chromosome_stability1.91548101
28MP0005275_abnormal_skin_tensile1.88664753
29MP0000685_abnormal_immune_system1.86796139
30MP0005671_abnormal_response_to1.84714917
31MP0003436_decreased_susceptibility_to1.84442132
32MP0008007_abnormal_cellular_replicative1.82377184
33MP0003941_abnormal_skin_development1.81495391
34MP0005410_abnormal_fertilization1.81229931
35MP0008058_abnormal_DNA_repair1.76538196
36MP0003656_abnormal_erythrocyte_physiolo1.75692665
37MP0004381_abnormal_hair_follicle1.74008562
38MP0008057_abnormal_DNA_replication1.72874921
39MP0005025_abnormal_response_to1.72261701
40MP0009780_abnormal_chondrocyte_physiolo1.70889555
41MP0004947_skin_inflammation1.66951052
42MP0004957_abnormal_blastocyst_morpholog1.66314637
43MP0002722_abnormal_immune_system1.66101197
44MP0001968_abnormal_touch/_nociception1.63927890
45MP0000689_abnormal_spleen_morphology1.62449783
46MP0000230_abnormal_systemic_arterial1.62230834
47MP0009278_abnormal_bone_marrow1.61165057
48MP0001853_heart_inflammation1.60924948
49MP0003111_abnormal_nucleus_morphology1.59355291
50MP0001800_abnormal_humoral_immune1.56629117
51MP0002132_abnormal_respiratory_system1.54138061
52MP0003077_abnormal_cell_cycle1.53103800
53MP0005084_abnormal_gallbladder_morpholo1.51920832
54MP0008775_abnormal_heart_ventricle1.51676320
55MP0002420_abnormal_adaptive_immunity1.51647755
56MP0002234_abnormal_pharynx_morphology1.51570927
57MP0003011_delayed_dark_adaptation1.51314809
58MP0008875_abnormal_xenobiotic_pharmacok1.50614259
59MP0003724_increased_susceptibility_to1.49616970
60MP0010155_abnormal_intestine_physiology1.48921242
61MP0001819_abnormal_immune_cell1.47442810
62MP0002452_abnormal_antigen_presenting1.47419879
63MP0002429_abnormal_blood_cell1.45949556
64MP0001873_stomach_inflammation1.44953620
65MP0002723_abnormal_immune_serum1.43922136
66MP0006054_spinal_hemorrhage1.41936717
67MP0000716_abnormal_immune_system1.39137411
68MP0004084_abnormal_cardiac_muscle1.37104222
69MP0002060_abnormal_skin_morphology1.35680835
70MP0001188_hyperpigmentation1.35507640
71MP0005646_abnormal_pituitary_gland1.35354491
72MP0003943_abnormal_hepatobiliary_system1.35286621
73MP0005000_abnormal_immune_tolerance1.34978376
74MP0009053_abnormal_anal_canal1.34890348
75MP0003786_premature_aging1.34657344
76MP0001216_abnormal_epidermal_layer1.34077376
77MP0002148_abnormal_hypersensitivity_rea1.33315198
78MP0002877_abnormal_melanocyte_morpholog1.32890482
79MP0006292_abnormal_olfactory_placode1.32256383
80MP0000647_abnormal_sebaceous_gland1.31453998
81MP0005167_abnormal_blood-brain_barrier1.31038815
82MP0004885_abnormal_endolymph1.29939922
83MP0002419_abnormal_innate_immunity1.29734658
84MP0002102_abnormal_ear_morphology1.29557001
85MP0000703_abnormal_thymus_morphology1.28740538
86MP0001986_abnormal_taste_sensitivity1.25869193
87MP0002166_altered_tumor_susceptibility1.25776930
88MP0004043_abnormal_pH_regulation1.25385990
89MP0005377_hearing/vestibular/ear_phenot1.24266650
90MP0003878_abnormal_ear_physiology1.24266650
91MP0009333_abnormal_splenocyte_physiolog1.21258591
92MP0003866_abnormal_defecation1.20992901
93MP0003567_abnormal_fetal_cardiomyocyte1.20106553
94MP0009931_abnormal_skin_appearance1.18856545
95MP0002019_abnormal_tumor_incidence1.18812758
96MP0002405_respiratory_system_inflammati1.14901499
97MP0001765_abnormal_ion_homeostasis1.13433601
98MP0000015_abnormal_ear_pigmentation1.13164904
99MP0000762_abnormal_tongue_morphology1.12936965
100MP0010771_integument_phenotype1.11555331
101MP0009697_abnormal_copulation1.10496423
102MP0001191_abnormal_skin_condition1.08747660
103MP0010352_gastrointestinal_tract_polyps1.06979129
104MP0003566_abnormal_cell_adhesion1.04899452
105MP0001851_eye_inflammation1.04552795
106MP0005409_darkened_coat_color1.00858035
107MP0000579_abnormal_nail_morphology0.99133309
108MP0000383_abnormal_hair_follicle0.97644767
109MP0005551_abnormal_eye_electrophysiolog0.96653762
110MP0001879_abnormal_lymphatic_vessel0.96240068
111MP0009764_decreased_sensitivity_to0.96229194
112MP0003718_maternal_effect0.96072859
113MP0003950_abnormal_plasma_membrane0.95769198
114MP0001845_abnormal_inflammatory_respons0.95680863
115MP0010329_abnormal_lipoprotein_level0.95675460
116MP0003879_abnormal_hair_cell0.95555488
117MP0003453_abnormal_keratinocyte_physiol0.95236044
118MP0002006_tumorigenesis0.95151443
119MP0000313_abnormal_cell_death0.94896428
120MP0002098_abnormal_vibrissa_morphology0.94811679
121MP0004142_abnormal_muscle_tone0.94117732
122MP0004130_abnormal_muscle_cell0.93515052
123MP0003828_pulmonary_edema0.93452565
124MP0002733_abnormal_thermal_nociception0.92408648
125MP0003186_abnormal_redox_activity0.89048154
126MP0005193_abnormal_anterior_eye0.87558273
127MP0000377_abnormal_hair_follicle0.86729869
128MP0000372_irregular_coat_pigmentation0.84966456
129MP0010234_abnormal_vibrissa_follicle0.84764206
130MP0004215_abnormal_myocardial_fiber0.83979933
131MP0000343_altered_response_to0.83953388
132MP0004484_altered_response_of0.83676955
133MP0000367_abnormal_coat/_hair0.83409703
134MP0004036_abnormal_muscle_relaxation0.81637913
135MP0002075_abnormal_coat/hair_pigmentati0.80074406
136MP0005023_abnormal_wound_healing0.78640662
137MP0008469_abnormal_protein_level0.77734070
138MP0004019_abnormal_vitamin_homeostasis0.77561330
139MP0004264_abnormal_extraembryonic_tissu0.76621563
140MP0002254_reproductive_system_inflammat0.76403311
141MP0000566_synostosis0.75706493
142MP0006036_abnormal_mitochondrial_physio0.75248745
143MP0000467_abnormal_esophagus_morphology0.74615261
144MP0003638_abnormal_response/metabolism_0.74135743
145MP0004510_myositis0.73465390
146MP0001756_abnormal_urination0.72921147
147MP0001905_abnormal_dopamine_level0.72681728
148MP0002697_abnormal_eye_size0.72294586
149MP0005387_immune_system_phenotype0.72003754
150MP0001790_abnormal_immune_system0.72003754
151MP0003045_fibrosis0.71061254
152MP0009765_abnormal_xenobiotic_induced0.70569333
153MP0006035_abnormal_mitochondrial_morpho0.67922971
154MP0006276_abnormal_autonomic_nervous0.67852444
155MP0002653_abnormal_ependyma_morphology0.67763657
156MP0000358_abnormal_cell_content/0.65008382
157MP0000249_abnormal_blood_vessel0.64931027
158MP0001970_abnormal_pain_threshold0.63353379
159MP0000858_altered_metastatic_potential0.62419838
160MP0009763_increased_sensitivity_to0.61565136
161MP0001849_ear_inflammation0.61375919
162MP0000569_abnormal_digit_pigmentation0.61337629

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.73219684
2Abnormal number of erythroid precursors (HP:0012131)6.38571102
3Petechiae (HP:0000967)5.72059374
4Reticulocytopenia (HP:0001896)5.46651117
5Aplastic anemia (HP:0001915)5.27259902
6Thrombocytosis (HP:0001894)5.23586544
7Abnormality of the heme biosynthetic pathway (HP:0010472)5.09463639
8Prolonged bleeding time (HP:0003010)5.05101015
9Plantar hyperkeratosis (HP:0007556)4.96343545
10Thick nail (HP:0001805)4.72555273
11Fragile nails (HP:0001808)4.56803077
12Palmoplantar hyperkeratosis (HP:0000972)4.42151943
13Nuclear cataract (HP:0100018)4.22280894
14Alopecia of scalp (HP:0002293)4.22097679
15Pallor (HP:0000980)4.21576174
16Palmar hyperkeratosis (HP:0010765)4.13926818
17Milia (HP:0001056)4.09736780
18Hyperlipoproteinemia (HP:0010980)4.00950455
19Zonular cataract (HP:0010920)3.76832391
20Macrocytic anemia (HP:0001972)3.68223252
21Increased IgE level (HP:0003212)3.58089388
22Epistaxis (HP:0000421)3.51348459
23Purpura (HP:0000979)3.42746046
24Erythema (HP:0010783)3.38458212
25Abnormal platelet function (HP:0011869)3.32680658
26Impaired platelet aggregation (HP:0003540)3.32680658
27Nail dystrophy (HP:0008404)3.20227633
28Amaurosis fugax (HP:0100576)3.16133800
29Chronic otitis media (HP:0000389)3.14088622
30Elevated erythrocyte sedimentation rate (HP:0003565)3.12976828
31IgM deficiency (HP:0002850)3.08094848
32Myositis (HP:0100614)3.06681710
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.05476659
34Oral leukoplakia (HP:0002745)2.98288438
35Abnormal platelet volume (HP:0011876)2.91101717
36Hypotrichosis (HP:0001006)2.91023741
37Decreased central vision (HP:0007663)2.90128226
38Dyschromatopsia (HP:0007641)2.88979508
39Muscle fiber atrophy (HP:0100295)2.87106578
40Myelodysplasia (HP:0002863)2.85491343
41Gingival bleeding (HP:0000225)2.85144051
4211 pairs of ribs (HP:0000878)2.81943880
43Erythroderma (HP:0001019)2.77165877
44Type I transferrin isoform profile (HP:0003642)2.75730292
45Colon cancer (HP:0003003)2.72539331
46Type 2 muscle fiber atrophy (HP:0003554)2.70621837
47Asplenia (HP:0001746)2.66325680
48Ridged nail (HP:0001807)2.63672356
49Poikilocytosis (HP:0004447)2.58305875
50Abnormal auditory evoked potentials (HP:0006958)2.57671565
51Increased mean platelet volume (HP:0011877)2.55440389
52Menorrhagia (HP:0000132)2.55302387
533-Methylglutaconic aciduria (HP:0003535)2.49453505
54Sparse eyelashes (HP:0000653)2.48967573
55Corneal erosion (HP:0200020)2.47844927
56Paralysis (HP:0003470)2.47394401
57Acanthocytosis (HP:0001927)2.44549225
58Reduced antithrombin III activity (HP:0001976)2.43358201
59Abnormal pupillary function (HP:0007686)2.40338574
60Aplasia/Hypoplasia of the spleen (HP:0010451)2.39253871
61Pancytopenia (HP:0001876)2.37045878
62Abnormality of the nasal mucosa (HP:0000433)2.36876348
63Abnormality of the prostate (HP:0008775)2.36509425
64Poikiloderma (HP:0001029)2.35006999
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33995365
66Abnormality of alanine metabolism (HP:0010916)2.33995365
67Hyperalaninemia (HP:0003348)2.33995365
68Microcytic anemia (HP:0001935)2.27988443
69Woolly hair (HP:0002224)2.26955736
70Basal cell carcinoma (HP:0002671)2.26364491
71Abnormality of lateral ventricle (HP:0030047)2.26188490
72Generalized aminoaciduria (HP:0002909)2.23959724
73Hypoplastic labia majora (HP:0000059)2.23472581
74Pili torti (HP:0003777)2.23005555
75Parakeratosis (HP:0001036)2.22420923
76Furrowed tongue (HP:0000221)2.20303823
77Acute myeloid leukemia (HP:0004808)2.19082131
78Right ventricular cardiomyopathy (HP:0011663)2.17397253
79Microretrognathia (HP:0000308)2.17140299
80Migraine (HP:0002076)2.13407535
81Abnormality of reticulocytes (HP:0004312)2.11646199
82Abnormality of the neuromuscular junction (HP:0003398)2.07793210
83Fatigable weakness (HP:0003473)2.07793210
84Agnosia (HP:0010524)2.07380900
85Abnormality of the labia majora (HP:0012881)2.06365211
86Acute lymphatic leukemia (HP:0006721)2.04764811
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.02434496
88Amelogenesis imperfecta (HP:0000705)2.01750795
89Sparse scalp hair (HP:0002209)2.01702709
90Hyperthyroidism (HP:0000836)2.00359346
91Stomatitis (HP:0010280)1.99834618
92Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99488935
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99488935
94Widely spaced teeth (HP:0000687)1.98648529
95Abnormal protein glycosylation (HP:0012346)1.98244554
96Abnormal glycosylation (HP:0012345)1.98244554
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98244554
98Abnormal protein N-linked glycosylation (HP:0012347)1.98244554
99Onycholysis (HP:0001806)1.97965939
100Abnormal blistering of the skin (HP:0008066)1.96874173
101Recurrent abscess formation (HP:0002722)1.96493799
102Abnormality of placental membranes (HP:0011409)1.96265202
103Amniotic constriction ring (HP:0009775)1.96265202
104Abnormal hair laboratory examination (HP:0003328)1.95666444
105Abnormality of the renal cortex (HP:0011035)1.95520737
106Palmoplantar keratoderma (HP:0000982)1.94870338
107Cellulitis (HP:0100658)1.94761342
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94458556
109Tongue fasciculations (HP:0001308)1.93825850
110Abnormality of T cell physiology (HP:0011840)1.93583750
111Orchitis (HP:0100796)1.93109249
112Lymphoma (HP:0002665)1.92926270
113Recurrent bacterial skin infections (HP:0005406)1.92637300
114Gangrene (HP:0100758)1.92581719
115Lip pit (HP:0100267)1.92040945
116Weak cry (HP:0001612)1.91934545
117Nasal polyposis (HP:0100582)1.91445388
118Abnormality of the axillary hair (HP:0100134)1.91387786
119Abnormality of secondary sexual hair (HP:0009888)1.91387786
120Abnormal ciliary motility (HP:0012262)1.91193707
121Tinnitus (HP:0000360)1.90830711
122Patchy hypopigmentation of hair (HP:0011365)1.90567923
123Congenital, generalized hypertrichosis (HP:0004540)1.87444430
124Granulocytopenia (HP:0001913)1.87338624
125Pancreatic cysts (HP:0001737)1.84906684
126Congenital cataract (HP:0000519)1.83087352
127Congenital stationary night blindness (HP:0007642)1.82870727
128Respiratory difficulties (HP:0002880)1.82852500
129Increased serum ferritin (HP:0003281)1.82266610
130Vascular calcification (HP:0004934)1.81579651
131Abnormal respiratory motile cilium morphology (HP:0005938)1.79205728
132Abnormal respiratory epithelium morphology (HP:0012253)1.79205728
133Thyroid-stimulating hormone excess (HP:0002925)1.78788516
134Congenital ichthyosiform erythroderma (HP:0007431)1.78670334
135Conical tooth (HP:0000698)1.78606039
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77416221
137Upper limb muscle weakness (HP:0003484)1.77299817
138Ectropion (HP:0000656)1.77294480
139Selective tooth agenesis (HP:0001592)1.77292146
140Entropion (HP:0000621)1.76946634
141Prostate neoplasm (HP:0100787)1.76509260
142Abnormality of the preputium (HP:0100587)1.75831772
143Pruritus (HP:0000989)1.75564660
144Absent/shortened dynein arms (HP:0200106)1.73215354
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.73215354
146Dry hair (HP:0011359)1.73019117
147Clubbing of toes (HP:0100760)1.72676853
148Increased density of long bones (HP:0006392)1.71957254
149Abnormality of the columella (HP:0009929)1.71864158
150Abnormality of nail color (HP:0100643)1.70958008
151Biliary tract neoplasm (HP:0100574)1.69296658
152Hypergammaglobulinemia (HP:0010702)1.69263412
153Absent thumb (HP:0009777)1.68740099
154Breast hypoplasia (HP:0003187)1.68643814
155Pustule (HP:0200039)1.67816268
156Muscle fibrillation (HP:0010546)1.67680221
157Hypohidrosis (HP:0000966)1.67664033
158Spontaneous hematomas (HP:0007420)1.66999875
159Hepatocellular necrosis (HP:0001404)1.66880787
160Hypoplasia of the uterus (HP:0000013)1.66303187
161Neutropenia (HP:0001875)1.65404570
162Recurrent bronchitis (HP:0002837)1.65126709
163Bone marrow hypocellularity (HP:0005528)1.64889341
164Eczematoid dermatitis (HP:0000976)1.64109657
165Bruising susceptibility (HP:0000978)1.63941172
166Popliteal pterygium (HP:0009756)1.63495100
167Pancreatic fibrosis (HP:0100732)1.62678451
168Abnormality of midbrain morphology (HP:0002418)1.60149230
169Molar tooth sign on MRI (HP:0002419)1.60149230
170Attenuation of retinal blood vessels (HP:0007843)1.60147818
171Ventricular fibrillation (HP:0001663)1.60113114
172Abnormality of the common coagulation pathway (HP:0010990)1.58875910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.07777117
2KIT2.91870284
3NME22.90030575
4EEF2K2.79071601
5TGFBR12.76380142
6BMX2.73811650
7WEE12.72632667
8STK162.55141868
9RPS6KB22.52373079
10TIE12.52369443
11PTK2B2.43729814
12ADRBK22.43265633
13MAP2K32.37827071
14PIK3CG2.31387718
15CDK192.27945804
16MAP4K12.27022098
17EPHA22.17580616
18PIM22.17262254
19MUSK2.16594408
20MAP3K122.15984372
21MAPKAPK32.08201799
22BMPR1B1.98991074
23FLT31.97078455
24BTK1.92623894
25MAPKAPK51.89811163
26MATK1.89667469
27TGFBR21.89133443
28TEC1.80004549
29GRK51.78775527
30STK31.75396619
31TNIK1.74059445
32TLK11.72625022
33FER1.69559446
34MAP4K21.60896214
35EPHB21.55143805
36MET1.53886586
37MAP2K61.53769555
38GRK11.51527572
39TXK1.45427897
40LRRK21.41345537
41VRK11.40911405
42CCNB11.38176026
43CSF1R1.36697780
44ADRBK11.36347970
45CDK71.32154084
46NUAK11.31978665
47CDC71.30531606
48MAP3K31.29934038
49SYK1.28819050
50MKNK11.26857030
51TBK11.25353175
52ZAP701.24913925
53ZAK1.22464381
54IKBKE1.22100923
55BMPR21.20024592
56GRK61.17843486
57TRIM281.17748654
58TYK21.16426043
59PASK1.15658646
60JAK31.14746502
61TRPM71.14538143
62BLK1.12925360
63SRPK11.12616967
64MAP3K21.11522964
65IRAK11.09947809
66IKBKB1.08801789
67TNK21.05911932
68IRAK41.05709574
69CDK81.05670126
70DYRK31.01367345
71BRSK21.00536275
72TSSK60.98459079
73PLK40.98241318
74ACVR1B0.96198910
75MAP3K60.96108399
76PLK20.96024066
77BUB10.93926207
78LMTK20.92455419
79PIM10.91807060
80PRKG20.90365372
81PAK30.87237343
82MAPK130.87045803
83NEK20.86637656
84PINK10.84065797
85STK100.83229295
86EPHA30.81565961
87PKN20.80853595
88PAK40.79861266
89LYN0.78649170
90ERBB20.78472516
91STK38L0.78096325
92PRKCE0.77987378
93SIK30.77666280
94EPHB10.77637645
95KDR0.77609884
96SCYL20.74707286
97AURKB0.73298042
98RPS6KA60.73249937
99FGR0.72860172
100MAP3K110.71484991
101BCR0.70795010
102EIF2AK10.69665225
103PAK10.69253202
104DAPK20.69056213
105ATR0.68684533
106LCK0.68293021
107INSRR0.66917643
108DAPK30.65193323
109NME10.63885707
110RPS6KA40.63187705
111FES0.62989893
112WNK40.62303671
113MAP2K10.61860653
114ARAF0.61799413
115MAPK40.61342979
116ILK0.57183326
117RIPK40.57125764
118OXSR10.56384188
119PNCK0.55695859
120ERN10.54909151
121MAP3K90.54437061
122RPS6KA50.53324024
123MAPK110.53236961
124HCK0.52649290
125STK240.52081334
126BCKDK0.52046784
127PHKG20.51720673
128PHKG10.51720673
129RPS6KC10.50871668
130RPS6KL10.50871668
131PRKCI0.49569800
132MST1R0.48722846
133MAP3K50.46436548
134CSNK1G30.46408432
135CLK10.46334465
136MYLK0.46171418
137PKN10.46048153
138CAMK10.45377434
139ITK0.44442267
140MST40.44182067
141STK390.43515837
142EIF2AK30.43495315
143MAPKAPK20.43274185
144DYRK20.42514908
145MAP2K20.42479427
146ABL20.40974099
147DAPK10.40573131
148PRKCQ0.39880968
149ROCK10.39634673
150CSNK2A20.39552919
151PRKD10.39319732
152PLK10.38503028
153PTK20.38444573
154CDK60.38121400
155CDK40.38104533
156CAMKK20.37836030
157MINK10.37061224
158RAF10.36862536
159WNK30.36427220
160EIF2AK20.35876796
161TAOK30.35253793
162HIPK20.35131264
163ABL10.33983954
164PRKCD0.33364004
165IGF1R0.32852945
166NTRK10.31443601

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.35148889
2DNA replication_Homo sapiens_hsa030304.66572802
3Mismatch repair_Homo sapiens_hsa034303.92562649
4Nitrogen metabolism_Homo sapiens_hsa009102.77402874
5Base excision repair_Homo sapiens_hsa034102.75110297
6Nucleotide excision repair_Homo sapiens_hsa034202.58341280
7Phototransduction_Homo sapiens_hsa047442.52156125
8Homologous recombination_Homo sapiens_hsa034402.45646541
9RNA polymerase_Homo sapiens_hsa030202.43033321
10ECM-receptor interaction_Homo sapiens_hsa045122.41303384
11Spliceosome_Homo sapiens_hsa030402.28762584
12Pyrimidine metabolism_Homo sapiens_hsa002402.23387995
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06009897
14Collecting duct acid secretion_Homo sapiens_hsa049662.04580826
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98464021
16Sulfur metabolism_Homo sapiens_hsa009201.97475922
17Proteasome_Homo sapiens_hsa030501.92408884
18Fatty acid elongation_Homo sapiens_hsa000621.77717330
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73856697
20Serotonergic synapse_Homo sapiens_hsa047261.73514998
21Fanconi anemia pathway_Homo sapiens_hsa034601.69031019
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62581159
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.59982942
24Chemical carcinogenesis_Homo sapiens_hsa052041.57063426
25Hematopoietic cell lineage_Homo sapiens_hsa046401.55335903
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50110726
27Cell cycle_Homo sapiens_hsa041101.47197089
28RNA degradation_Homo sapiens_hsa030181.46873301
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44687023
30Ether lipid metabolism_Homo sapiens_hsa005651.42681371
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.41971774
32Platelet activation_Homo sapiens_hsa046111.39782084
33Herpes simplex infection_Homo sapiens_hsa051681.38703856
34Glycerolipid metabolism_Homo sapiens_hsa005611.37148304
35p53 signaling pathway_Homo sapiens_hsa041151.37128663
36RNA transport_Homo sapiens_hsa030131.36866347
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34411988
38Olfactory transduction_Homo sapiens_hsa047401.32690911
39Folate biosynthesis_Homo sapiens_hsa007901.29950967
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24361506
41Non-homologous end-joining_Homo sapiens_hsa034501.20411484
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18204365
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17388476
44Caffeine metabolism_Homo sapiens_hsa002321.13414756
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12490184
46Basal transcription factors_Homo sapiens_hsa030221.12457006
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12045043
48Acute myeloid leukemia_Homo sapiens_hsa052211.10963244
49Measles_Homo sapiens_hsa051621.09977924
50Primary immunodeficiency_Homo sapiens_hsa053401.09719041
51Purine metabolism_Homo sapiens_hsa002301.09168848
52Leishmaniasis_Homo sapiens_hsa051401.08670867
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07765354
54B cell receptor signaling pathway_Homo sapiens_hsa046621.06060156
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.04484569
56Arachidonic acid metabolism_Homo sapiens_hsa005901.02869284
57Sulfur relay system_Homo sapiens_hsa041221.01505322
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01048753
59Long-term depression_Homo sapiens_hsa047300.99473243
60Ovarian steroidogenesis_Homo sapiens_hsa049130.97145524
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96471202
62Chemokine signaling pathway_Homo sapiens_hsa040620.95726387
63Gap junction_Homo sapiens_hsa045400.94684154
64Steroid biosynthesis_Homo sapiens_hsa001000.94545580
65Regulation of autophagy_Homo sapiens_hsa041400.93110271
66Pancreatic secretion_Homo sapiens_hsa049720.92258967
67One carbon pool by folate_Homo sapiens_hsa006700.91921536
68Endocytosis_Homo sapiens_hsa041440.91573958
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91390916
70beta-Alanine metabolism_Homo sapiens_hsa004100.90670544
71N-Glycan biosynthesis_Homo sapiens_hsa005100.90438022
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88118342
73Circadian entrainment_Homo sapiens_hsa047130.87922361
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87317340
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86273069
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86255079
77Epstein-Barr virus infection_Homo sapiens_hsa051690.85215778
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84391149
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83399199
80Thyroid cancer_Homo sapiens_hsa052160.78349948
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78303851
82Hepatitis B_Homo sapiens_hsa051610.77949423
83ABC transporters_Homo sapiens_hsa020100.77777660
84Fat digestion and absorption_Homo sapiens_hsa049750.77211714
85Retinol metabolism_Homo sapiens_hsa008300.76704413
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.76498993
87Pentose phosphate pathway_Homo sapiens_hsa000300.76146425
88Legionellosis_Homo sapiens_hsa051340.75327404
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.74535290
90Calcium signaling pathway_Homo sapiens_hsa040200.73783533
91Morphine addiction_Homo sapiens_hsa050320.73635721
92Apoptosis_Homo sapiens_hsa042100.72939321
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.72924662
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71266360
95Systemic lupus erythematosus_Homo sapiens_hsa053220.71066752
96Shigellosis_Homo sapiens_hsa051310.70734045
97Antigen processing and presentation_Homo sapiens_hsa046120.70211256
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68876003
99Starch and sucrose metabolism_Homo sapiens_hsa005000.68462399
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68224116
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66130307
102Osteoclast differentiation_Homo sapiens_hsa043800.65168672
103Oxidative phosphorylation_Homo sapiens_hsa001900.64062921
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62923141
105Influenza A_Homo sapiens_hsa051640.61810352
106Other glycan degradation_Homo sapiens_hsa005110.61433338
107Small cell lung cancer_Homo sapiens_hsa052220.60564000
108Viral carcinogenesis_Homo sapiens_hsa052030.60468266
109Glutathione metabolism_Homo sapiens_hsa004800.59463625
110Protein export_Homo sapiens_hsa030600.58335145
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57647282
112Ras signaling pathway_Homo sapiens_hsa040140.55639029
113Pertussis_Homo sapiens_hsa051330.54318107
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54097745
115Phagosome_Homo sapiens_hsa041450.53240250
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.52318504
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52000151
118Focal adhesion_Homo sapiens_hsa045100.50665645
119Salivary secretion_Homo sapiens_hsa049700.50441920
120GABAergic synapse_Homo sapiens_hsa047270.50170307
121Toxoplasmosis_Homo sapiens_hsa051450.49710828
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47778073
123Parkinsons disease_Homo sapiens_hsa050120.46789660
124Sphingolipid metabolism_Homo sapiens_hsa006000.45927628
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.45908303
126Galactose metabolism_Homo sapiens_hsa000520.45678313
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44997937
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44966471
129Notch signaling pathway_Homo sapiens_hsa043300.44745231
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44406813
131Glutamatergic synapse_Homo sapiens_hsa047240.44343665
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43943756
133HTLV-I infection_Homo sapiens_hsa051660.42699314
134Tyrosine metabolism_Homo sapiens_hsa003500.42288316
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.42172290
136mRNA surveillance pathway_Homo sapiens_hsa030150.42077316
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41553263
138Gastric acid secretion_Homo sapiens_hsa049710.40503969
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40482389
140Chronic myeloid leukemia_Homo sapiens_hsa052200.39233104
141Non-small cell lung cancer_Homo sapiens_hsa052230.38900149
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.38812302
143TNF signaling pathway_Homo sapiens_hsa046680.37172725
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36779074
145Hepatitis C_Homo sapiens_hsa051600.36701056
146Synaptic vesicle cycle_Homo sapiens_hsa047210.36686965
147Malaria_Homo sapiens_hsa051440.35793578
148Linoleic acid metabolism_Homo sapiens_hsa005910.34724376
149Circadian rhythm_Homo sapiens_hsa047100.34496029
150Renin secretion_Homo sapiens_hsa049240.34448633
151Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34198429
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.33250605
153Butanoate metabolism_Homo sapiens_hsa006500.31730673
154T cell receptor signaling pathway_Homo sapiens_hsa046600.30567670
155Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29997130
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.29320597
157Choline metabolism in cancer_Homo sapiens_hsa052310.29048204
158Rap1 signaling pathway_Homo sapiens_hsa040150.28728785
159Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28713514
160alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26106471
161VEGF signaling pathway_Homo sapiens_hsa043700.25698817
162Asthma_Homo sapiens_hsa053100.22651031
163Alcoholism_Homo sapiens_hsa050340.22120847
164HIF-1 signaling pathway_Homo sapiens_hsa040660.20007915

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