TMEM41A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.30519032
2maturation of SSU-rRNA (GO:0030490)6.74463394
3viral transcription (GO:0019083)6.36292860
4translational termination (GO:0006415)6.19043583
5DNA deamination (GO:0045006)6.00037498
6translational elongation (GO:0006414)5.65394120
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.37642675
8cotranslational protein targeting to membrane (GO:0006613)5.24475665
9protein targeting to ER (GO:0045047)5.21078037
10ribosomal small subunit biogenesis (GO:0042274)5.20697636
11protein localization to endoplasmic reticulum (GO:0070972)4.97727250
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.94729234
13viral life cycle (GO:0019058)4.87517773
14cellular protein complex disassembly (GO:0043624)4.85131481
15proteasome assembly (GO:0043248)4.81456296
16translational initiation (GO:0006413)4.81284330
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.79235560
18ribosomal large subunit biogenesis (GO:0042273)4.75558417
19L-fucose catabolic process (GO:0042355)4.55949092
20fucose catabolic process (GO:0019317)4.55949092
21L-fucose metabolic process (GO:0042354)4.55949092
22pseudouridine synthesis (GO:0001522)4.49498752
23telomere maintenance via semi-conservative replication (GO:0032201)4.41726432
24prenylation (GO:0097354)4.37229603
25protein prenylation (GO:0018342)4.37229603
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.33040365
27ribonucleoprotein complex biogenesis (GO:0022613)4.29078003
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.26970942
29DNA replication initiation (GO:0006270)4.25924505
30protein complex disassembly (GO:0043241)4.21974277
31DNA strand elongation involved in DNA replication (GO:0006271)4.21895153
32translation (GO:0006412)4.04183696
33energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02513596
34ATP synthesis coupled proton transport (GO:0015986)4.02513596
35macromolecular complex disassembly (GO:0032984)4.01875119
36DNA strand elongation (GO:0022616)3.99246048
37formation of translation preinitiation complex (GO:0001731)3.98004022
38oxidative phosphorylation (GO:0006119)3.91934442
39cellular component biogenesis (GO:0044085)3.88672756
40ribosome biogenesis (GO:0042254)3.88171062
41telomere maintenance via recombination (GO:0000722)3.81638383
42purine nucleobase biosynthetic process (GO:0009113)3.80218123
43mitochondrial respiratory chain complex assembly (GO:0033108)3.78734895
44respiratory chain complex IV assembly (GO:0008535)3.77085368
45nucleobase biosynthetic process (GO:0046112)3.75286237
46termination of RNA polymerase III transcription (GO:0006386)3.73497615
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.73497615
48protein complex biogenesis (GO:0070271)3.72988224
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.65887374
50NADH dehydrogenase complex assembly (GO:0010257)3.65887374
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65887374
52rRNA processing (GO:0006364)3.62107845
53nuclear-transcribed mRNA catabolic process (GO:0000956)3.59024540
54regulation of mitochondrial translation (GO:0070129)3.56588474
55regulation of cellular amino acid metabolic process (GO:0006521)3.54962929
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54718368
57preassembly of GPI anchor in ER membrane (GO:0016254)3.53829385
58rRNA metabolic process (GO:0016072)3.51942127
59tRNA methylation (GO:0030488)3.51803916
60protein-cofactor linkage (GO:0018065)3.49210553
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.48636161
62deoxyribose phosphate biosynthetic process (GO:0046385)3.47787987
632-deoxyribonucleotide biosynthetic process (GO:0009265)3.47787987
64mRNA catabolic process (GO:0006402)3.41302496
65protein targeting to membrane (GO:0006612)3.41131815
66metallo-sulfur cluster assembly (GO:0031163)3.39924038
67iron-sulfur cluster assembly (GO:0016226)3.39924038
68chaperone-mediated protein transport (GO:0072321)3.38808434
69kynurenine metabolic process (GO:0070189)3.38089916
70tryptophan catabolic process (GO:0006569)3.30842182
71indole-containing compound catabolic process (GO:0042436)3.30842182
72indolalkylamine catabolic process (GO:0046218)3.30842182
73positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30397459
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30397459
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.30397459
76oxidative demethylation (GO:0070989)3.28688905
77tryptophan metabolic process (GO:0006568)3.28259804
78mannosylation (GO:0097502)3.26623972
79mitotic recombination (GO:0006312)3.26423979
80pteridine-containing compound biosynthetic process (GO:0042559)3.26316628
81indolalkylamine metabolic process (GO:0006586)3.25292805
82telomere maintenance via telomere lengthening (GO:0010833)3.25074196
83nucleobase-containing small molecule interconversion (GO:0015949)3.24899903
84negative regulation of ligase activity (GO:0051352)3.22926517
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22926517
86water-soluble vitamin biosynthetic process (GO:0042364)3.22616270
87RNA catabolic process (GO:0006401)3.21378121
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20962207
89viral mRNA export from host cell nucleus (GO:0046784)3.20865870
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16827620
91pyrimidine nucleotide catabolic process (GO:0006244)3.16713744
92DNA unwinding involved in DNA replication (GO:0006268)3.16001890
93cytochrome complex assembly (GO:0017004)3.14410819
94folic acid-containing compound biosynthetic process (GO:0009396)3.12672725
95pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.11924857
96sulfation (GO:0051923)3.11551797
97protein targeting to mitochondrion (GO:0006626)3.11525473
98spliceosomal snRNP assembly (GO:0000387)3.11255255
99protein K11-linked deubiquitination (GO:0035871)3.09756667
100respiratory electron transport chain (GO:0022904)3.08800305
101DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07270237
102establishment of integrated proviral latency (GO:0075713)3.06926494
103nucleotide-excision repair, DNA gap filling (GO:0006297)3.06562250
104gonadal mesoderm development (GO:0007506)3.06074236
105pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05394205
106rRNA modification (GO:0000154)3.05259702
107electron transport chain (GO:0022900)3.04876140
108signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01915972
109intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01915972
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.01886304
111cornea development in camera-type eye (GO:0061303)3.01674115
112protein K6-linked ubiquitination (GO:0085020)3.01150812
113signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99586186
114signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99586186
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99586186
116mitochondrial RNA metabolic process (GO:0000959)2.97761521
117establishment of protein localization to mitochondrion (GO:0072655)2.96862179
118ribosome assembly (GO:0042255)2.96053587
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95187409
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.92451912
121response to pheromone (GO:0019236)2.92310648
122deoxyribonucleotide biosynthetic process (GO:0009263)2.90679791
123signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90511902
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.90511902
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90413621
126GPI anchor metabolic process (GO:0006505)2.90071979
127behavioral response to nicotine (GO:0035095)2.89119992
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86294101
129methionine biosynthetic process (GO:0009086)2.82445270
130intestinal cholesterol absorption (GO:0030299)2.74682431
131purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.74377879
1323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.74377879
133high-density lipoprotein particle remodeling (GO:0034375)2.73988955
134recombinational repair (GO:0000725)2.73190354
135replication fork processing (GO:0031297)2.73128571
136positive regulation of prostaglandin secretion (GO:0032308)2.70829251
137cellular ketone body metabolic process (GO:0046950)2.70474566
138S-adenosylmethionine metabolic process (GO:0046500)2.70364055
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70085689
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.70085689
141double-strand break repair via homologous recombination (GO:0000724)2.69932060
142piRNA metabolic process (GO:0034587)2.68587915
143cellular biogenic amine catabolic process (GO:0042402)2.68459343
144amine catabolic process (GO:0009310)2.68459343
145benzene-containing compound metabolic process (GO:0042537)2.66736072
146keratinocyte development (GO:0003334)2.66566522
147L-methionine salvage (GO:0071267)2.66562638
148L-methionine biosynthetic process (GO:0071265)2.66562638
149amino acid salvage (GO:0043102)2.66562638
150fucosylation (GO:0036065)2.64230751
151tRNA processing (GO:0008033)2.62861060
152regulation of glucokinase activity (GO:0033131)2.59050831
153regulation of hexokinase activity (GO:1903299)2.59050831
154C-terminal protein lipidation (GO:0006501)2.58630106
155maturation of 5.8S rRNA (GO:0000460)2.54985051
156DNA demethylation (GO:0080111)2.53679270
157nucleotide transmembrane transport (GO:1901679)2.53339223
158GPI anchor biosynthetic process (GO:0006506)2.52346218
159methionine metabolic process (GO:0006555)2.50995440
160aromatic amino acid family catabolic process (GO:0009074)2.49969869
161platelet dense granule organization (GO:0060155)2.48355681
162tRNA modification (GO:0006400)2.47777863
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46823625
164cobalamin metabolic process (GO:0009235)2.45635120
165nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43806952
166C-terminal protein amino acid modification (GO:0018410)2.43595708
167sulfur amino acid biosynthetic process (GO:0000097)2.43080191
168synapsis (GO:0007129)2.42904321
169estrogen biosynthetic process (GO:0006703)2.42821717
170mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42655210
171dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.42352470
172ketone body metabolic process (GO:1902224)2.40449478
173DNA integration (GO:0015074)2.39509067
174organelle membrane fusion (GO:0090174)2.39394128
175detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39058229
176autophagic vacuole fusion (GO:0000046)2.35833818
177DNA methylation involved in gamete generation (GO:0043046)2.35823392
178flavonoid metabolic process (GO:0009812)2.35163181
179regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.33727457
180tRNA metabolic process (GO:0006399)2.33055206
181aromatic amino acid family metabolic process (GO:0009072)2.32094278
182negative regulation of transcription regulatory region DNA binding (GO:2000678)2.31782040
183DNA double-strand break processing (GO:0000729)2.30585573
184regulation of hippo signaling (GO:0035330)2.30402243
185drug catabolic process (GO:0042737)2.29695728
186acrosome assembly (GO:0001675)2.28591854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.15245540
2E2F7_22180533_ChIP-Seq_HELA_Human5.02110551
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.82487795
4VDR_22108803_ChIP-Seq_LS180_Human4.09166173
5ZNF274_21170338_ChIP-Seq_K562_Hela3.64144037
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.57475378
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50564521
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.34842410
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.18312874
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.13606169
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01365713
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00281780
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.94851437
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92381423
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82775962
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80768102
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75299602
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51817125
19XRN2_22483619_ChIP-Seq_HELA_Human2.50061965
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42551957
21* VDR_23849224_ChIP-Seq_CD4+_Human2.37119828
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36826990
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.34308178
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31902720
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27854592
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20101416
27* GABP_19822575_ChIP-Seq_HepG2_Human2.17320099
28DCP1A_22483619_ChIP-Seq_HELA_Human2.17253483
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16592566
30NOTCH1_21737748_ChIP-Seq_TLL_Human2.16443166
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14414534
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12212622
33ZNF263_19887448_ChIP-Seq_K562_Human2.02312088
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99545174
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.98638556
36* TTF2_22483619_ChIP-Seq_HELA_Human1.97964728
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97826027
38GBX2_23144817_ChIP-Seq_PC3_Human1.96373277
39FUS_26573619_Chip-Seq_HEK293_Human1.95625349
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95459579
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93944904
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91488911
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.87303017
44EWS_26573619_Chip-Seq_HEK293_Human1.87046896
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85366143
46* FOXP3_21729870_ChIP-Seq_TREG_Human1.85317533
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84672839
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.80757314
49* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79412922
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78013370
51* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77619267
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77065670
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75415418
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73701258
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.72703230
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70185539
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64831919
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.64727903
59IGF1R_20145208_ChIP-Seq_DFB_Human1.63960790
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.59063904
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57691148
62IRF1_19129219_ChIP-ChIP_H3396_Human1.56219186
63ER_23166858_ChIP-Seq_MCF-7_Human1.55880772
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55502852
65TAF15_26573619_Chip-Seq_HEK293_Human1.52989408
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52432063
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52232656
68P300_19829295_ChIP-Seq_ESCs_Human1.51579477
69MYC_18940864_ChIP-ChIP_HL60_Human1.49606456
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47860575
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47407540
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42918914
73TP53_22573176_ChIP-Seq_HFKS_Human1.41815357
74MYC_22102868_ChIP-Seq_BL_Human1.38187326
75GATA1_22025678_ChIP-Seq_K562_Human1.37816112
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37429073
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37147930
78CBP_20019798_ChIP-Seq_JUKART_Human1.37147930
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36598695
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35967546
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35894647
82AR_21909140_ChIP-Seq_LNCAP_Human1.35176539
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34664388
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34325582
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32979758
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32802418
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31763113
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.31763113
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31191138
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28619941
91* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27463873
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27334930
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26116359
94BCAT_22108803_ChIP-Seq_LS180_Human1.25447670
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.25300008
96ELK1_22589737_ChIP-Seq_MCF10A_Human1.23325946
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23180704
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22846131
99ELK1_19687146_ChIP-ChIP_HELA_Human1.21558692
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20695590
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20522287
102KDM5A_27292631_Chip-Seq_BREAST_Human1.20432643
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19936944
104TCF4_22108803_ChIP-Seq_LS180_Human1.18706941
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17274819
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16971553
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15700530
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15520399
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14463667
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14189188
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13047983
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13019700
113STAT3_23295773_ChIP-Seq_U87_Human1.12218124
114AR_20517297_ChIP-Seq_VCAP_Human1.12166548
115NANOG_19829295_ChIP-Seq_ESCs_Human1.12077658
116SOX2_19829295_ChIP-Seq_ESCs_Human1.12077658
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12063302
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11966233
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11925771
120* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11784108
121HOXB7_26014856_ChIP-Seq_BT474_Human1.09151764
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08261916
123CIITA_25753668_ChIP-Seq_RAJI_Human1.07424718
124* CDX2_22108803_ChIP-Seq_LS180_Human1.07295474
125VDR_21846776_ChIP-Seq_THP-1_Human1.07073090
126KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06600836
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05739692
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04484115
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03543996
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03351855
131NFE2_27457419_Chip-Seq_LIVER_Mouse1.03039427
132* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02143972
133EZH2_27294783_Chip-Seq_NPCs_Mouse1.01467403
134* GATA4_25053715_ChIP-Seq_YYC3_Human1.00803025
135AR_25329375_ChIP-Seq_VCAP_Human1.00735636
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00433728
137TCF4_23295773_ChIP-Seq_U87_Human0.99909084
138* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98911953
139* GATA3_21878914_ChIP-Seq_MCF-7_Human0.98239428
140NCOR_22424771_ChIP-Seq_293T_Human0.97596297
141SMAD4_21799915_ChIP-Seq_A2780_Human0.97218858
142E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97196242
143FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96791822
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96371911
145RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94819653
146TP63_19390658_ChIP-ChIP_HaCaT_Human0.94662146
147ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93509077
148KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93138927
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92990139
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92964564
151RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92717510
152FOXP1_21924763_ChIP-Seq_HESCs_Human0.92460835
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91733273
154SPI1_23547873_ChIP-Seq_NB4_Human0.91704003
155PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91532829
156SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91454498
157FOXH1_21741376_ChIP-Seq_EPCs_Human0.91059067
158YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90909854
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90733819
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90676388
161PHF8_20622853_ChIP-Seq_HELA_Human0.90531954
162EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89566185
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89320811
164CRX_20693478_ChIP-Seq_RETINA_Mouse0.88222091
165KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87981187
166TP53_16413492_ChIP-PET_HCT116_Human0.87974994
167SCL_19346495_ChIP-Seq_HPC-7_Human0.87163403
168TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85479228
169HTT_18923047_ChIP-ChIP_STHdh_Human0.85390536
170STAT3_18555785_Chip-Seq_ESCs_Mouse0.85272316
171YY1_22570637_ChIP-Seq_MALME-3M_Human0.83907068
172OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82654053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.36305646
2MP0003693_abnormal_embryo_hatching4.14381105
3MP0004957_abnormal_blastocyst_morpholog3.19733013
4MP0004147_increased_porphyrin_level3.18251840
5MP0006036_abnormal_mitochondrial_physio3.06871081
6MP0003806_abnormal_nucleotide_metabolis2.95791200
7MP0006035_abnormal_mitochondrial_morpho2.81407835
8MP0002876_abnormal_thyroid_physiology2.76265708
9MP0002396_abnormal_hematopoietic_system2.67310024
10MP0003195_calcinosis2.63012549
11MP0001545_abnormal_hematopoietic_system2.62953872
12MP0005397_hematopoietic_system_phenotyp2.62953872
13MP0000566_synostosis2.57705072
14MP0010094_abnormal_chromosome_stability2.39169837
15MP0003656_abnormal_erythrocyte_physiolo2.37866372
16MP0005360_urolithiasis2.33701354
17MP0008877_abnormal_DNA_methylation2.29495348
18MP0003123_paternal_imprinting2.23532809
19MP0000490_abnormal_crypts_of2.20619734
20MP0002138_abnormal_hepatobiliary_system2.17089826
21MP0006054_spinal_hemorrhage2.12725017
22MP0003077_abnormal_cell_cycle2.08535916
23MP0001666_abnormal_nutrient_absorption2.04406840
24MP0005085_abnormal_gallbladder_physiolo1.96905928
25MP0003186_abnormal_redox_activity1.96904941
26MP0009697_abnormal_copulation1.96256291
27MP0002139_abnormal_hepatobiliary_system1.94340045
28MP0008995_early_reproductive_senescence1.93761229
29MP0010352_gastrointestinal_tract_polyps1.92167930
30MP0000383_abnormal_hair_follicle1.91018574
31MP0002102_abnormal_ear_morphology1.90749188
32MP0002132_abnormal_respiratory_system1.86224429
33MP0002938_white_spotting1.86041977
34MP0005551_abnormal_eye_electrophysiolog1.82442024
35MP0003941_abnormal_skin_development1.77730910
36MP0003111_abnormal_nucleus_morphology1.76915963
37MP0010234_abnormal_vibrissa_follicle1.76617572
38MP0003763_abnormal_thymus_physiology1.67660004
39MP0000427_abnormal_hair_cycle1.66178420
40MP0008932_abnormal_embryonic_tissue1.65659099
41MP0009840_abnormal_foam_cell1.65463759
42MP0005075_abnormal_melanosome_morpholog1.61541821
43MP0002796_impaired_skin_barrier1.56472864
44MP0008007_abnormal_cellular_replicative1.53675925
45MP0001919_abnormal_reproductive_system1.51748324
46MP0000647_abnormal_sebaceous_gland1.51384178
47MP0008058_abnormal_DNA_repair1.47939133
48MP0005646_abnormal_pituitary_gland1.45365989
49MP0008872_abnormal_physiological_respon1.42156817
50MP0008875_abnormal_xenobiotic_pharmacok1.41776893
51MP0005332_abnormal_amino_acid1.41232831
52MP0004019_abnormal_vitamin_homeostasis1.41052417
53MP0005083_abnormal_biliary_tract1.40547423
54MP0002160_abnormal_reproductive_system1.40276232
55MP0000358_abnormal_cell_content/1.39768710
56MP0004142_abnormal_muscle_tone1.37615623
57MP0005501_abnormal_skin_physiology1.37041098
58MP0001764_abnormal_homeostasis1.36459839
59MP0005410_abnormal_fertilization1.32920653
60MP0010678_abnormal_skin_adnexa1.32053269
61MP0003890_abnormal_embryonic-extraembry1.30140103
62MP0003866_abnormal_defecation1.29736496
63MP0009333_abnormal_splenocyte_physiolog1.29065291
64MP0000372_irregular_coat_pigmentation1.27874342
65MP0005636_abnormal_mineral_homeostasis1.27300294
66MP0004808_abnormal_hematopoietic_stem1.26824349
67MP0005365_abnormal_bile_salt1.26249114
68MP0000631_abnormal_neuroendocrine_gland1.24572613
69MP0008057_abnormal_DNA_replication1.24258947
70MP0002751_abnormal_autonomic_nervous1.24071509
71MP0002638_abnormal_pupillary_reflex1.23313992
72MP0003937_abnormal_limbs/digits/tail_de1.21398010
73MP0005395_other_phenotype1.21109243
74MP0008789_abnormal_olfactory_epithelium1.19543134
75MP0002210_abnormal_sex_determination1.19230638
76MP0005084_abnormal_gallbladder_morpholo1.18566432
77MP0005266_abnormal_metabolism1.17851417
78MP0004043_abnormal_pH_regulation1.17503518
79MP0004264_abnormal_extraembryonic_tissu1.15484582
80MP0006072_abnormal_retinal_apoptosis1.15462812
81MP0005253_abnormal_eye_physiology1.14713831
82MP0000313_abnormal_cell_death1.13793710
83MP0002837_dystrophic_cardiac_calcinosis1.10648988
84MP0001730_embryonic_growth_arrest1.10428860
85MP0001929_abnormal_gametogenesis1.10051920
86MP0002019_abnormal_tumor_incidence1.09534754
87MP0003315_abnormal_perineum_morphology1.06851269
88MP0001119_abnormal_female_reproductive1.06541296
89MP0003950_abnormal_plasma_membrane1.04600046
90MP0002166_altered_tumor_susceptibility1.03718855
91MP0003252_abnormal_bile_duct1.03509022
92MP0000653_abnormal_sex_gland1.02308371
93MP0003718_maternal_effect1.02145552
94MP0002722_abnormal_immune_system1.01456394
95MP0003786_premature_aging1.01138146
96MP0005174_abnormal_tail_pigmentation1.00939061
97MP0006292_abnormal_olfactory_placode0.99953909
98MP0002234_abnormal_pharynx_morphology0.97334102
99MP0002163_abnormal_gland_morphology0.97175514
100MP0004215_abnormal_myocardial_fiber0.96703150
101MP0002089_abnormal_postnatal_growth/wei0.96666920
102MP0004133_heterotaxia0.95992782
103MP0001986_abnormal_taste_sensitivity0.95464055
104MP0000477_abnormal_intestine_morphology0.94917054
105MP0003011_delayed_dark_adaptation0.92553003
106MP0003136_yellow_coat_color0.91431892
107MP0005464_abnormal_platelet_physiology0.91337076
108MP0010329_abnormal_lipoprotein_level0.91005503
109MP0005220_abnormal_exocrine_pancreas0.90889808
110MP0005379_endocrine/exocrine_gland_phen0.90353208
111MP0003724_increased_susceptibility_to0.90306060
112MP0000678_abnormal_parathyroid_gland0.89394493
113MP0002736_abnormal_nociception_after0.89181727
114MP0003943_abnormal_hepatobiliary_system0.88702735
115MP0000350_abnormal_cell_proliferation0.88376458
116MP0001145_abnormal_male_reproductive0.88065941
117MP0004145_abnormal_muscle_electrophysio0.87802658
118MP0001216_abnormal_epidermal_layer0.87688100
119MP0002398_abnormal_bone_marrow0.87454644
120MP0009931_abnormal_skin_appearance0.87283448
121MP0003936_abnormal_reproductive_system0.86680276
122MP0005319_abnormal_enzyme/_coenzyme0.85776935
123MP0002080_prenatal_lethality0.85664620
124MP0010155_abnormal_intestine_physiology0.84313998
125MP0003638_abnormal_response/metabolism_0.83999059
126MP0000516_abnormal_urinary_system0.83512742
127MP0005367_renal/urinary_system_phenotyp0.83512742
128MP0000689_abnormal_spleen_morphology0.83220574
129MP0000639_abnormal_adrenal_gland0.82543522
130MP0005499_abnormal_olfactory_system0.82229716
131MP0005394_taste/olfaction_phenotype0.82229716
132MP0001697_abnormal_embryo_size0.81410890
133MP0001324_abnormal_eye_pigmentation0.81402648
134MP0006276_abnormal_autonomic_nervous0.80901755
135MP0001188_hyperpigmentation0.80679414
136MP0001293_anophthalmia0.80278550
137MP0005408_hypopigmentation0.78421253
138MP0003698_abnormal_male_reproductive0.78334513
139MP0001968_abnormal_touch/_nociception0.78059798
140MP0002822_catalepsy0.77483198
141MP0002429_abnormal_blood_cell0.76287167
142MP0001663_abnormal_digestive_system0.75370763
143MP0003567_abnormal_fetal_cardiomyocyte0.74174972
144MP0010771_integument_phenotype0.74144891
145MP0001485_abnormal_pinna_reflex0.73929259
146MP0003646_muscle_fatigue0.72373718
147MP0004885_abnormal_endolymph0.71675440
148MP0005584_abnormal_enzyme/coenzyme_acti0.71138913
149MP0005187_abnormal_penis_morphology0.70446930
150MP0005376_homeostasis/metabolism_phenot0.69811796
151MP0001873_stomach_inflammation0.69673641
152MP0000703_abnormal_thymus_morphology0.69483323
153MP0004782_abnormal_surfactant_physiolog0.68882571
154MP0005389_reproductive_system_phenotype0.68859442
155MP0000681_abnormal_thyroid_gland0.68163866
156MP0008775_abnormal_heart_ventricle0.66868964
157MP0002098_abnormal_vibrissa_morphology0.66757635
158MP0002095_abnormal_skin_pigmentation0.66467705
159MP0001984_abnormal_olfaction0.65583847
160MP0001664_abnormal_digestion0.65353401
161MP0000538_abnormal_urinary_bladder0.65020315
162MP0003221_abnormal_cardiomyocyte_apopto0.64711549

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.66411348
2Abnormal number of erythroid precursors (HP:0012131)6.45053930
3Aplastic anemia (HP:0001915)5.58949178
4Reticulocytopenia (HP:0001896)4.52794853
5Abnormality of the heme biosynthetic pathway (HP:0010472)4.49608991
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.26683849
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.26683849
8Hepatocellular necrosis (HP:0001404)4.24690768
9Increased hepatocellular lipid droplets (HP:0006565)4.21510087
10Mitochondrial inheritance (HP:0001427)4.15794809
11Increased CSF lactate (HP:0002490)4.01543111
12Macrocytic anemia (HP:0001972)3.99476879
13Increased intramyocellular lipid droplets (HP:0012240)3.94926685
14Hepatic necrosis (HP:0002605)3.92742557
15Lipid accumulation in hepatocytes (HP:0006561)3.92428282
16Pallor (HP:0000980)3.84635857
17Acute necrotizing encephalopathy (HP:0006965)3.81600164
18Abnormal mitochondria in muscle tissue (HP:0008316)3.73981243
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.65335612
20Oral leukoplakia (HP:0002745)3.58988442
21Pancreatic cysts (HP:0001737)3.56282337
22Increased muscle lipid content (HP:0009058)3.50980755
23Colon cancer (HP:0003003)3.37995686
24Acute encephalopathy (HP:0006846)3.32606313
25Pancreatic fibrosis (HP:0100732)3.29477481
26Increased serum lactate (HP:0002151)3.28660283
27Lactic acidosis (HP:0003128)3.26974815
28True hermaphroditism (HP:0010459)3.18250416
29Conjunctival hamartoma (HP:0100780)3.15856828
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.14979330
3111 pairs of ribs (HP:0000878)3.08044336
32Exertional dyspnea (HP:0002875)3.07094226
33Renal Fanconi syndrome (HP:0001994)3.05437011
34Microretrognathia (HP:0000308)3.01426293
35Progressive macrocephaly (HP:0004481)2.98604192
36Respiratory difficulties (HP:0002880)2.94833369
37Abnormality of the renal collecting system (HP:0004742)2.94103836
38Duplicated collecting system (HP:0000081)2.92692204
39Abnormality of midbrain morphology (HP:0002418)2.91489912
40Molar tooth sign on MRI (HP:0002419)2.91489912
41Petechiae (HP:0000967)2.88353446
42Abnormality of the renal cortex (HP:0011035)2.86935126
43Chronic hepatic failure (HP:0100626)2.81727958
44Large for gestational age (HP:0001520)2.60575103
453-Methylglutaconic aciduria (HP:0003535)2.59747287
46Type I transferrin isoform profile (HP:0003642)2.59221294
47Reduced antithrombin III activity (HP:0001976)2.56265712
48Exercise intolerance (HP:0003546)2.56147325
49Respiratory failure (HP:0002878)2.55113649
50Renal cortical cysts (HP:0000803)2.52600407
51Cerebral edema (HP:0002181)2.52294596
52Abnormality of reticulocytes (HP:0004312)2.51336120
53Poor suck (HP:0002033)2.45982375
54Hyperglycinuria (HP:0003108)2.40969864
55Sparse eyelashes (HP:0000653)2.40914698
56Acanthocytosis (HP:0001927)2.39745235
57Emotional lability (HP:0000712)2.39415817
58Palpitations (HP:0001962)2.38686240
59Pancytopenia (HP:0001876)2.38332290
60Concave nail (HP:0001598)2.36161276
61Nephronophthisis (HP:0000090)2.34092030
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34035995
63Ragged-red muscle fibers (HP:0003200)2.33293865
64Thrombocytosis (HP:0001894)2.31583047
65Hyperglycinemia (HP:0002154)2.31194424
66Abolished electroretinogram (ERG) (HP:0000550)2.28332489
67Hyperphosphaturia (HP:0003109)2.27952768
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.27256879
69Abnormality of B cell number (HP:0010975)2.26883876
70B lymphocytopenia (HP:0010976)2.26883876
71Type II lissencephaly (HP:0007260)2.26231643
72Esophageal neoplasm (HP:0100751)2.26032407
73Neoplasm of head and neck (HP:0012288)2.26032407
74Hypoplasia of the uterus (HP:0000013)2.25641054
75Abnormality of vitamin B metabolism (HP:0004340)2.25575549
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24782035
77Methylmalonic aciduria (HP:0012120)2.24341292
78Abnormality of urine glucose concentration (HP:0011016)2.23875878
79Glycosuria (HP:0003076)2.23875878
80Male pseudohermaphroditism (HP:0000037)2.23597255
81Pendular nystagmus (HP:0012043)2.23404757
82Rough bone trabeculation (HP:0100670)2.23186013
83Abnormality of the vitamin B12 metabolism (HP:0004341)2.23012087
84Abnormality of the renal medulla (HP:0100957)2.22800023
85Methylmalonic acidemia (HP:0002912)2.21558630
86Hypoplastic pelvis (HP:0008839)2.18695890
87Abnormality of serum amino acid levels (HP:0003112)2.16742460
88Medial flaring of the eyebrow (HP:0010747)2.15783634
89Aplasia/hypoplasia of the uterus (HP:0008684)2.14459290
90Hypobetalipoproteinemia (HP:0003563)2.13125594
91Abnormal biliary tract physiology (HP:0012439)2.12450589
92Bile duct proliferation (HP:0001408)2.12450589
93Decreased circulating renin level (HP:0003351)2.12126658
94Severe muscular hypotonia (HP:0006829)2.12068750
95Attenuation of retinal blood vessels (HP:0007843)2.11678692
96Abnormality of serine family amino acid metabolism (HP:0010894)2.08592953
97Abnormality of glycine metabolism (HP:0010895)2.08592953
98Congenital stationary night blindness (HP:0007642)2.08260291
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08155259
100Abnormal protein N-linked glycosylation (HP:0012347)2.08155259
101Abnormal protein glycosylation (HP:0012346)2.08155259
102Abnormal glycosylation (HP:0012345)2.08155259
103Microcytic anemia (HP:0001935)2.07949330
104Abnormality of the preputium (HP:0100587)2.04856963
105Gaze-evoked nystagmus (HP:0000640)2.02198943
106Multiple enchondromatosis (HP:0005701)1.99478256
107Aplasia/Hypoplasia of the tibia (HP:0005772)1.99290408
108Tubular atrophy (HP:0000092)1.98862121
109CNS demyelination (HP:0007305)1.98822249
110Abnormal hemoglobin (HP:0011902)1.97955643
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.97765811
112Adenoma sebaceum (HP:0009720)1.96933220
113Angiofibromas (HP:0010615)1.96933220
114Ureteral duplication (HP:0000073)1.94904841
115Dry hair (HP:0011359)1.94775162
116Abnormality of the pons (HP:0007361)1.93866792
117Erythema (HP:0010783)1.93647330
118Abnormality of renal resorption (HP:0011038)1.93627997
119Congenital, generalized hypertrichosis (HP:0004540)1.92972692
120Cerebral hypomyelination (HP:0006808)1.92405343
121Birth length less than 3rd percentile (HP:0003561)1.91974473
122Sclerocornea (HP:0000647)1.91328315
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.91021312
124Neuroendocrine neoplasm (HP:0100634)1.90702936
125Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89934889
126Chorioretinal atrophy (HP:0000533)1.89600129
127Hypoplasia of the pons (HP:0012110)1.89166840
128Cystic liver disease (HP:0006706)1.88305271
129Steatorrhea (HP:0002570)1.87143822
130Proximal tubulopathy (HP:0000114)1.86858674
131Progressive muscle weakness (HP:0003323)1.86409444
132Abnormality of alanine metabolism (HP:0010916)1.86402908
133Hyperalaninemia (HP:0003348)1.86402908
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86402908
135Clubbing of toes (HP:0100760)1.86149574
136Furrowed tongue (HP:0000221)1.86144531
137Megaloblastic anemia (HP:0001889)1.85906105
138Neoplasm of the adrenal gland (HP:0100631)1.85509465
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85378332
140Chromsome breakage (HP:0040012)1.85352918
141Metabolic acidosis (HP:0001942)1.85216439
142Poikilocytosis (HP:0004447)1.84669591
143Abnormality of methionine metabolism (HP:0010901)1.83786419
144Aplasia/Hypoplasia of the fovea (HP:0008060)1.83006572
145Hypoplasia of the fovea (HP:0007750)1.83006572
146Lethargy (HP:0001254)1.82025695
147Cerebellar dysplasia (HP:0007033)1.80768892
148Abnormal drinking behavior (HP:0030082)1.80352764
149Polydipsia (HP:0001959)1.80352764
150Microvesicular hepatic steatosis (HP:0001414)1.79443969
151Meckel diverticulum (HP:0002245)1.79133076
152Fat malabsorption (HP:0002630)1.78931789
153Abnormality of the ileum (HP:0001549)1.77551615
154Brushfield spots (HP:0001088)1.76887447
155Abnormality of glutamine family amino acid metabolism (HP:0010902)1.75739996
156Absent thumb (HP:0009777)1.75004324
157Hypothermia (HP:0002045)1.74920794
158Abnormality of sulfur amino acid metabolism (HP:0004339)1.74416218
159Delusions (HP:0000746)1.73608330
160IgM deficiency (HP:0002850)1.70663135
161Intestinal polyposis (HP:0200008)1.69826982
162Abnormality of secondary sexual hair (HP:0009888)1.67683893
163Abnormality of the axillary hair (HP:0100134)1.67683893
164Optic disc pallor (HP:0000543)1.67614203
165Abnormality of glycolysis (HP:0004366)1.67608343
166Increased serum pyruvate (HP:0003542)1.67608343
167Abnormal urine phosphate concentration (HP:0012599)1.66188272
168Hyperbilirubinemia (HP:0002904)1.65892323
169Severe visual impairment (HP:0001141)1.64025571
170Nausea (HP:0002018)1.62384503
171Intestinal polyp (HP:0005266)1.61757905
172Selective tooth agenesis (HP:0001592)1.60573906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.51446042
2MKNK25.37201503
3NME24.81377823
4FRK3.93631033
5PIM23.83941184
6BUB13.34608920
7ARAF3.28331280
8TAOK32.81074783
9TGFBR12.78350170
10WEE12.72590071
11NEK12.70591436
12NUAK12.50379759
13BMPR1B2.45746481
14ZAK2.36358035
15WNK32.06966681
16MAP3K112.02002377
17PDK22.01599819
18MAP3K122.00987312
19PKN21.95559884
20STK391.92302763
21VRK11.91564238
22GRK11.91212551
23TRIM281.79639421
24NME11.78947165
25TNIK1.76950298
26ACVR1B1.71247050
27MAP4K21.68277055
28TLK11.65517147
29BRAF1.64792734
30EIF2AK11.60003575
31BCKDK1.59908123
32SCYL21.58841150
33WNK41.58729040
34RAF11.57120421
35RPS6KB21.51050039
36SRPK11.50157026
37VRK21.48618277
38MAPKAPK51.47256004
39OXSR11.46937674
40LRRK21.43411858
41MAPKAPK31.40087944
42PINK11.38265233
43CDC71.37520958
44TGFBR21.37399703
45MUSK1.36705758
46TSSK61.33113682
47KDR1.29477297
48AKT31.23810952
49EPHA21.23409454
50FLT31.16816893
51MAP2K21.15700868
52NEK21.14662363
53TESK21.13242272
54INSRR1.10943327
55CDK191.09984425
56PBK1.09128538
57MAP3K41.08307221
58EIF2AK31.07025723
59CDK71.04296513
60MAP4K11.02276280
61TAOK21.02264712
62STK38L0.99995284
63CCNB10.96341008
64AURKA0.95943846
65STK30.94968453
66MAPK130.93192239
67AURKB0.86184652
68ABL20.85373255
69MAP2K60.84374468
70BCR0.80756280
71MAP3K30.77096762
72PLK40.74121457
73ADRBK20.73242321
74BRSK20.73234726
75PRKCE0.73011605
76MATK0.72270092
77TBK10.72259543
78MAP2K70.72219917
79RPS6KA40.69657857
80MST40.68437655
81PLK10.68009187
82MST1R0.66098561
83STK240.65928922
84DYRK30.64642160
85TAF10.64197182
86EIF2AK20.62206385
87ADRBK10.61858254
88CSNK1G10.61283268
89MAP3K50.60710823
90PRKG20.60657808
91KIT0.60428582
92EEF2K0.60308796
93TEC0.60090438
94PRKCI0.60025412
95CSNK1A1L0.58710921
96ATR0.58122126
97PAK30.56864024
98BLK0.56823596
99TAOK10.56823337
100MAP3K80.56666608
101CSNK2A20.56610066
102TTK0.56115134
103GRK50.55442495
104CSNK1A10.55142377
105PHKG10.53444452
106PHKG20.53444452
107TIE10.52852415
108DAPK10.52213176
109MAP3K10.49664280
110PASK0.49468601
111DYRK20.49097619
112STK100.48445306
113CSNK2A10.48387050
114CDK80.48207366
115ZAP700.48117542
116CSNK1G20.47175560
117IKBKB0.46160568
118FER0.45297246
119MAP2K30.45122708
120PRKCG0.44733808
121DYRK1A0.44490507
122ERBB30.44371440
123BTK0.44007248
124ILK0.43870462
125MKNK10.43703808
126SYK0.42300367
127GRK60.42251863
128KSR20.42001379
129TRIB30.41951035
130LATS10.41758445
131MET0.41535694
132MINK10.40254515
133MAP2K10.38498786
134PLK30.38412556
135CAMK10.37782946
136CHEK20.37660552
137PTK2B0.36771055
138CASK0.36604729
139PIM10.35752145
140TRPM70.35645805
141PRKCQ0.34506848
142MELK0.34127777
143CDK40.34035572
144PRKAA20.33773269
145RPS6KA50.33706328
146PLK20.33408979
147TESK10.32989540
148CSNK1E0.32051899
149MAPK40.30947824
150ATM0.30931694
151MAP3K90.29491632
152PAK10.28741049
153BRSK10.28720409
154RPS6KC10.25251980
155RPS6KL10.25251980
156CSNK1G30.24043690

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.64292246
2DNA replication_Homo sapiens_hsa030304.63537013
3Proteasome_Homo sapiens_hsa030504.02004382
4RNA polymerase_Homo sapiens_hsa030203.22784244
5Mismatch repair_Homo sapiens_hsa034303.12136094
6Pyrimidine metabolism_Homo sapiens_hsa002402.99025190
7Parkinsons disease_Homo sapiens_hsa050122.77747605
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73441284
9Oxidative phosphorylation_Homo sapiens_hsa001902.63211100
10Base excision repair_Homo sapiens_hsa034102.55641623
11Folate biosynthesis_Homo sapiens_hsa007902.51231924
12Spliceosome_Homo sapiens_hsa030402.42435025
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.17599480
14Butanoate metabolism_Homo sapiens_hsa006502.02230394
15Nucleotide excision repair_Homo sapiens_hsa034202.00703872
16Linoleic acid metabolism_Homo sapiens_hsa005911.90578900
17Huntingtons disease_Homo sapiens_hsa050161.89308952
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.87141543
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86727022
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.85248559
21RNA transport_Homo sapiens_hsa030131.81126864
22Sulfur relay system_Homo sapiens_hsa041221.79367394
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79260180
24Alzheimers disease_Homo sapiens_hsa050101.77979236
25Homologous recombination_Homo sapiens_hsa034401.77686153
26Tryptophan metabolism_Homo sapiens_hsa003801.72869990
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69674946
28Steroid biosynthesis_Homo sapiens_hsa001001.63622347
29Nitrogen metabolism_Homo sapiens_hsa009101.59571099
30Phototransduction_Homo sapiens_hsa047441.57639338
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53851800
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.52409032
33Purine metabolism_Homo sapiens_hsa002301.48411299
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46955510
35Selenocompound metabolism_Homo sapiens_hsa004501.42069083
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34815050
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.32942563
38One carbon pool by folate_Homo sapiens_hsa006701.31297750
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.27090855
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26357969
41Protein export_Homo sapiens_hsa030601.23959755
42Pentose phosphate pathway_Homo sapiens_hsa000301.23544347
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22971173
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22646595
45Glutathione metabolism_Homo sapiens_hsa004801.21820151
46Cell cycle_Homo sapiens_hsa041101.21803655
47RNA degradation_Homo sapiens_hsa030181.21197004
48Ether lipid metabolism_Homo sapiens_hsa005651.19597430
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16749839
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15105238
51Galactose metabolism_Homo sapiens_hsa000521.12958887
52Carbon metabolism_Homo sapiens_hsa012001.09047292
53Biosynthesis of amino acids_Homo sapiens_hsa012301.02544454
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99831371
55Thyroid cancer_Homo sapiens_hsa052160.98792297
56Caffeine metabolism_Homo sapiens_hsa002320.93597915
57Mineral absorption_Homo sapiens_hsa049780.89537507
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89477585
59N-Glycan biosynthesis_Homo sapiens_hsa005100.89230013
60Glycerolipid metabolism_Homo sapiens_hsa005610.88396821
61p53 signaling pathway_Homo sapiens_hsa041150.85901582
62Cardiac muscle contraction_Homo sapiens_hsa042600.80492823
63Pyruvate metabolism_Homo sapiens_hsa006200.80487163
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80349435
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80300315
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79908467
67Metabolic pathways_Homo sapiens_hsa011000.76062395
68Fat digestion and absorption_Homo sapiens_hsa049750.75551869
69Sphingolipid metabolism_Homo sapiens_hsa006000.75200705
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75014212
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.67076606
72Fanconi anemia pathway_Homo sapiens_hsa034600.65756822
73Fatty acid metabolism_Homo sapiens_hsa012120.64815696
74ABC transporters_Homo sapiens_hsa020100.62915450
75Arginine biosynthesis_Homo sapiens_hsa002200.60411446
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59724362
77Histidine metabolism_Homo sapiens_hsa003400.59695701
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59030451
79Renin-angiotensin system_Homo sapiens_hsa046140.58580585
80Fructose and mannose metabolism_Homo sapiens_hsa000510.57757837
81Ovarian steroidogenesis_Homo sapiens_hsa049130.57389110
82Basal transcription factors_Homo sapiens_hsa030220.56915975
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54418114
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53578168
85Propanoate metabolism_Homo sapiens_hsa006400.52920516
86Non-homologous end-joining_Homo sapiens_hsa034500.52540589
87Epstein-Barr virus infection_Homo sapiens_hsa051690.52262999
88Lysine degradation_Homo sapiens_hsa003100.52145419
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51236104
90Taste transduction_Homo sapiens_hsa047420.49711725
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47913979
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47826647
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46487768
94Peroxisome_Homo sapiens_hsa041460.45718913
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43587525
96Starch and sucrose metabolism_Homo sapiens_hsa005000.43418639
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42751330
98Chemical carcinogenesis_Homo sapiens_hsa052040.41819686
99Fatty acid degradation_Homo sapiens_hsa000710.41280571
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40947425
101Sulfur metabolism_Homo sapiens_hsa009200.37062093
102Circadian rhythm_Homo sapiens_hsa047100.36583695
103Vitamin digestion and absorption_Homo sapiens_hsa049770.35467009
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34852142
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33199163
106TGF-beta signaling pathway_Homo sapiens_hsa043500.32959067
107Olfactory transduction_Homo sapiens_hsa047400.32465136
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29764407
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.28693892
110Herpes simplex infection_Homo sapiens_hsa051680.21655139
111Phenylalanine metabolism_Homo sapiens_hsa003600.21259341
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19025562
113Acute myeloid leukemia_Homo sapiens_hsa052210.18844038
114Fatty acid elongation_Homo sapiens_hsa000620.18131604
115Oocyte meiosis_Homo sapiens_hsa041140.16974601
116Retinol metabolism_Homo sapiens_hsa008300.16120519
117Legionellosis_Homo sapiens_hsa051340.15871002
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15782793
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14464616
120Bladder cancer_Homo sapiens_hsa052190.14316347
121Alcoholism_Homo sapiens_hsa050340.13304264
122Arachidonic acid metabolism_Homo sapiens_hsa005900.12499822
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11502443
124beta-Alanine metabolism_Homo sapiens_hsa004100.11236050
125Arginine and proline metabolism_Homo sapiens_hsa003300.07196298
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.07067367
127Tyrosine metabolism_Homo sapiens_hsa003500.06282167
128Primary immunodeficiency_Homo sapiens_hsa053400.06197314
129Systemic lupus erythematosus_Homo sapiens_hsa053220.06176643
130mRNA surveillance pathway_Homo sapiens_hsa030150.05430216
131Apoptosis_Homo sapiens_hsa042100.04653489

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