TMEM42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.54845793
2protein-cofactor linkage (GO:0018065)4.67383552
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.66169709
4GDP-mannose metabolic process (GO:0019673)4.58778265
5protein complex biogenesis (GO:0070271)4.47411421
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.42063645
7respiratory chain complex IV assembly (GO:0008535)4.41798332
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.39905853
9ATP synthesis coupled proton transport (GO:0015986)4.39905853
10protein maturation by protein folding (GO:0022417)4.28237633
11signal peptide processing (GO:0006465)4.27798416
12regulation of mitochondrial translation (GO:0070129)4.06435816
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.04777275
14mitochondrial respiratory chain complex assembly (GO:0033108)4.00470147
15respiratory electron transport chain (GO:0022904)3.99741774
16GMP metabolic process (GO:0046037)3.99562445
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.97793346
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.95562814
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.95562814
20NADH dehydrogenase complex assembly (GO:0010257)3.95562814
21ribosomal small subunit assembly (GO:0000028)3.94647201
22electron transport chain (GO:0022900)3.93857860
23oxidative phosphorylation (GO:0006119)3.93421005
24metallo-sulfur cluster assembly (GO:0031163)3.92458214
25iron-sulfur cluster assembly (GO:0016226)3.92458214
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.84734928
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82501218
28chaperone-mediated protein transport (GO:0072321)3.82296110
29cotranslational protein targeting to membrane (GO:0006613)3.80931792
30GTP biosynthetic process (GO:0006183)3.79804338
31protein targeting to ER (GO:0045047)3.74664032
32substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.72513118
33substrate-independent telencephalic tangential migration (GO:0021826)3.72513118
34protein localization to endoplasmic reticulum (GO:0070972)3.69343172
35C-terminal protein lipidation (GO:0006501)3.67086124
36peptidyl-histidine modification (GO:0018202)3.65861244
37cullin deneddylation (GO:0010388)3.65578510
38cellular protein complex disassembly (GO:0043624)3.65542430
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.65116046
40L-phenylalanine catabolic process (GO:0006559)3.65116046
41cytochrome complex assembly (GO:0017004)3.63775611
42fucosylation (GO:0036065)3.58094658
43water-soluble vitamin biosynthetic process (GO:0042364)3.55088791
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.54768731
45polyketide metabolic process (GO:0030638)3.53978890
46doxorubicin metabolic process (GO:0044598)3.53978890
47daunorubicin metabolic process (GO:0044597)3.53978890
48COPI coating of Golgi vesicle (GO:0048205)3.51626915
49Golgi transport vesicle coating (GO:0048200)3.51626915
50protein neddylation (GO:0045116)3.49399148
51positive regulation of mitochondrial fission (GO:0090141)3.47711157
52regulation of oxidative phosphorylation (GO:0002082)3.46003870
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45079060
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.41818122
55rRNA modification (GO:0000154)3.40304266
56base-excision repair, AP site formation (GO:0006285)3.40044489
57pteridine-containing compound biosynthetic process (GO:0042559)3.38552320
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.36539644
59L-phenylalanine metabolic process (GO:0006558)3.36539644
60inner mitochondrial membrane organization (GO:0007007)3.35578138
61aldehyde catabolic process (GO:0046185)3.34981853
62ubiquinone biosynthetic process (GO:0006744)3.34860805
63quinone biosynthetic process (GO:1901663)3.34860805
64ribosomal large subunit biogenesis (GO:0042273)3.34291651
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.33515820
66termination of RNA polymerase III transcription (GO:0006386)3.33515820
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.31313264
68ATP biosynthetic process (GO:0006754)3.29822474
69negative regulation of membrane potential (GO:0045837)3.29249867
70translational initiation (GO:0006413)3.24932361
71antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23309998
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23309998
73C-terminal protein amino acid modification (GO:0018410)3.21024302
74intraciliary transport (GO:0042073)3.19456647
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19202734
76mannosylation (GO:0097502)3.16826666
77UTP biosynthetic process (GO:0006228)3.16802865
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16522351
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16522351
80protein complex disassembly (GO:0043241)3.14604945
81protein deneddylation (GO:0000338)3.12250436
82L-methionine salvage (GO:0071267)3.11623416
83L-methionine biosynthetic process (GO:0071265)3.11623416
84amino acid salvage (GO:0043102)3.11623416
85protein polyglutamylation (GO:0018095)3.11503053
86GPI anchor metabolic process (GO:0006505)3.11471335
87UTP metabolic process (GO:0046051)3.10711278
88platelet dense granule organization (GO:0060155)3.10287530
89aerobic respiration (GO:0009060)3.09357877
90nonmotile primary cilium assembly (GO:0035058)3.08764031
91glycoside metabolic process (GO:0016137)3.07757969
92viral transcription (GO:0019083)3.07690471
93intracellular protein transmembrane import (GO:0044743)3.07531195
94deoxyribonucleotide catabolic process (GO:0009264)3.06815950
95purine-containing compound salvage (GO:0043101)3.03452104
96establishment of protein localization to mitochondrion (GO:0072655)3.01978998
97sequestering of actin monomers (GO:0042989)3.01599502
98macromolecular complex disassembly (GO:0032984)3.00255589
99guanosine-containing compound biosynthetic process (GO:1901070)2.99920287
100maturation of 5.8S rRNA (GO:0000460)2.98624822
101negative regulation of glycoprotein biosynthetic process (GO:0010561)2.98007571
102translational termination (GO:0006415)2.96873327
103ubiquinone metabolic process (GO:0006743)2.95229657
104anterograde synaptic vesicle transport (GO:0048490)2.94983692
105protein localization to mitochondrion (GO:0070585)2.94878045
106fucose metabolic process (GO:0006004)2.94693112
107nucleoside diphosphate phosphorylation (GO:0006165)2.94303912
108hydrogen ion transmembrane transport (GO:1902600)2.93331393
109regulation of dopamine metabolic process (GO:0042053)2.93187978
110regulation of catecholamine metabolic process (GO:0042069)2.93187978
111branched-chain amino acid catabolic process (GO:0009083)2.91594766
112cellular component biogenesis (GO:0044085)2.91164371
113pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90008475
114epithelial cilium movement (GO:0003351)2.89070024
115fucose catabolic process (GO:0019317)2.87748838
116L-fucose metabolic process (GO:0042354)2.87748838
117L-fucose catabolic process (GO:0042355)2.87748838
118CTP biosynthetic process (GO:0006241)2.87393423
119CTP metabolic process (GO:0046036)2.87393423
120proteasome assembly (GO:0043248)2.85904893
121translation (GO:0006412)2.85687895
122purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.84850030
123maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74614414
124regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.72747985
125lipopolysaccharide biosynthetic process (GO:0009103)2.70288293
126pseudouridine synthesis (GO:0001522)2.69594661
127translational elongation (GO:0006414)2.68719158
128protein retention in ER lumen (GO:0006621)2.68331401
129pyrimidine nucleotide catabolic process (GO:0006244)2.67766907
130preassembly of GPI anchor in ER membrane (GO:0016254)2.67151045
131regulation of type B pancreatic cell apoptotic process (GO:2000674)2.65321032
132negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65072224
133nucleoside diphosphate catabolic process (GO:0009134)2.64975114
134ribosomal small subunit biogenesis (GO:0042274)2.64581780
135protein localization to Golgi apparatus (GO:0034067)2.64263045
136purine deoxyribonucleotide metabolic process (GO:0009151)2.61479189
137GPI anchor biosynthetic process (GO:0006506)2.60141003
138protein targeting to mitochondrion (GO:0006626)2.59938269
139maturation of SSU-rRNA (GO:0030490)2.59417408
140protein targeting to membrane (GO:0006612)2.55599482
141cellular metabolic compound salvage (GO:0043094)2.54744282
142pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.52551409
143quinone metabolic process (GO:1901661)2.52293261
144antigen processing and presentation of endogenous antigen (GO:0019883)2.52062645
145nucleotide-sugar metabolic process (GO:0009225)2.49303077
146dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.47509045
147viral life cycle (GO:0019058)2.46918496
148nucleotide transmembrane transport (GO:1901679)2.46819817
149ribonucleoside triphosphate biosynthetic process (GO:0009201)2.45892102
150dopamine transport (GO:0015872)2.45594555
151tRNA methylation (GO:0030488)2.45326987
152purine nucleoside triphosphate biosynthetic process (GO:0009145)2.44999643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.14324904
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.98500969
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.90924406
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68652450
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.62687126
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.42962659
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.38603333
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20658210
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.14191707
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03870337
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.94761585
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.87472241
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77049279
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67853954
15* MYC_18555785_ChIP-Seq_MESCs_Mouse2.62608890
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.58847720
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.54653059
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.48431704
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.46547381
20* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.40034736
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.37822615
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37343399
23VDR_23849224_ChIP-Seq_CD4+_Human2.33941057
24* ERG_20887958_ChIP-Seq_HPC-7_Mouse2.33530812
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.25192137
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.21089883
27ZNF274_21170338_ChIP-Seq_K562_Hela2.19110847
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15458706
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05157941
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03582415
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01235741
32GABP_19822575_ChIP-Seq_HepG2_Human1.96692456
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.95000783
34DCP1A_22483619_ChIP-Seq_HELA_Human1.90336099
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88991931
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87969961
37SCL_19346495_ChIP-Seq_HPC-7_Human1.86839111
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85321253
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82991854
40FOXP3_21729870_ChIP-Seq_TREG_Human1.81816739
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77050756
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71289712
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.67799070
44GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.64110764
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62458300
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60686562
47XRN2_22483619_ChIP-Seq_HELA_Human1.58373178
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57340880
49CTCF_18555785_ChIP-Seq_MESCs_Mouse1.56200978
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53812922
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53599344
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53181305
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50406811
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48258546
55GATA1_22025678_ChIP-Seq_K562_Human1.47909724
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47261422
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.43700417
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43108964
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42315167
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38564393
61* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38330673
62SPI1_23547873_ChIP-Seq_NB4_Human1.37342395
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.35851721
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34362549
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33472379
66CIITA_25753668_ChIP-Seq_RAJI_Human1.32826758
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30795873
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30377654
69EWS_26573619_Chip-Seq_HEK293_Human1.30094840
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29542855
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29516384
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.29460868
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27878200
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24594353
75TTF2_22483619_ChIP-Seq_HELA_Human1.24233807
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.23930006
77ERG_20517297_ChIP-Seq_VCAP_Human1.22679077
78IRF1_19129219_ChIP-ChIP_H3396_Human1.19154426
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17579635
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15994825
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15333153
82* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15052635
83ELK1_19687146_ChIP-ChIP_HELA_Human1.14221282
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11607643
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.09761044
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.08386062
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05702904
88TP53_22573176_ChIP-Seq_HFKS_Human1.04831453
89FOXP1_21924763_ChIP-Seq_HESCs_Human1.04784419
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04424348
91MYC_18940864_ChIP-ChIP_HL60_Human1.03357923
92FUS_26573619_Chip-Seq_HEK293_Human1.02776217
93BCL6_27268052_Chip-Seq_Bcells_Human1.02363802
94ERA_21632823_ChIP-Seq_H3396_Human1.01560776
95VDR_22108803_ChIP-Seq_LS180_Human1.01518368
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01472418
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01341048
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01032570
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00053539
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.99879808
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98322753
102AR_20517297_ChIP-Seq_VCAP_Human0.98132263
103NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97597891
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95406342
105EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94342940
106POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93419974
107NANOG_20526341_ChIP-Seq_ESCs_Human0.90846388
108CTCF_26484167_Chip-Seq_Bcells_Mouse0.89817223
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88665369
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88647343
111RNF2_27304074_Chip-Seq_NSC_Mouse0.88417728
112TP63_19390658_ChIP-ChIP_HaCaT_Human0.88219359
113FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87888316
114FOXA1_25329375_ChIP-Seq_VCAP_Human0.87888316
115SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87298782
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87273102
117CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86803788
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86150336
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85438102
120TAF2_19829295_ChIP-Seq_ESCs_Human0.84930874
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84524884
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84071533
123RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83603411
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82966541
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81761885
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80714940
127GATA3_21867929_ChIP-Seq_TH1_Mouse0.80640453
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79086416
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77955791
130RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77484532
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77022932
132* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77018425
133STAT4_19710469_ChIP-ChIP_TH1__Mouse0.75781713
134IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74879462
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74246587
136MYC_19079543_ChIP-ChIP_MESCs_Mouse0.73201673
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72981262
138IGF1R_20145208_ChIP-Seq_DFB_Human0.72682483
139* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72633038
140GATA3_21867929_ChIP-Seq_CD8_Mouse0.71978905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.69674475
2MP0001986_abnormal_taste_sensitivity3.11436153
3MP0003011_delayed_dark_adaptation2.93624205
4MP0008877_abnormal_DNA_methylation2.83866877
5MP0006072_abnormal_retinal_apoptosis2.78477091
6MP0005379_endocrine/exocrine_gland_phen2.73937693
7MP0004043_abnormal_pH_regulation2.65390838
8MP0003283_abnormal_digestive_organ2.53108459
9MP0005220_abnormal_exocrine_pancreas2.51941284
10MP0010386_abnormal_urinary_bladder2.28858360
11MP0002877_abnormal_melanocyte_morpholog2.25232495
12MP0006036_abnormal_mitochondrial_physio2.17233577
13MP0002693_abnormal_pancreas_physiology2.16364530
14MP0005551_abnormal_eye_electrophysiolog2.09986762
15MP0001944_abnormal_pancreas_morphology2.06292876
16MP0002102_abnormal_ear_morphology2.01839590
17MP0000013_abnormal_adipose_tissue1.96019023
18MP0009379_abnormal_foot_pigmentation1.95573524
19MP0003136_yellow_coat_color1.93043580
20MP0008789_abnormal_olfactory_epithelium1.92622467
21MP0003122_maternal_imprinting1.90658499
22MP0005084_abnormal_gallbladder_morpholo1.85331419
23MP0003880_abnormal_central_pattern1.84886521
24MP0002163_abnormal_gland_morphology1.83003896
25MP0002909_abnormal_adrenal_gland1.77845550
26MP0002938_white_spotting1.75835718
27MP0002638_abnormal_pupillary_reflex1.75467520
28MP0005671_abnormal_response_to1.73352362
29MP0003787_abnormal_imprinting1.71952573
30MP0001764_abnormal_homeostasis1.71250075
31MP0006292_abnormal_olfactory_placode1.68624809
32MP0004147_increased_porphyrin_level1.67776160
33MP0004133_heterotaxia1.67206770
34MP0003868_abnormal_feces_composition1.65642441
35MP0005075_abnormal_melanosome_morpholog1.64998131
36MP0005253_abnormal_eye_physiology1.58098759
37MP0002139_abnormal_hepatobiliary_system1.57737990
38MP0005310_abnormal_salivary_gland1.53300984
39MP0003183_abnormal_peptide_metabolism1.52384380
40MP0009046_muscle_twitch1.51366569
41MP0001529_abnormal_vocalization1.51337101
42MP0003724_increased_susceptibility_to1.51182445
43MP0009745_abnormal_behavioral_response1.51128981
44MP0003866_abnormal_defecation1.49741860
45MP0002837_dystrophic_cardiac_calcinosis1.49219003
46MP0009780_abnormal_chondrocyte_physiolo1.46625879
47MP0005646_abnormal_pituitary_gland1.46203494
48MP0001905_abnormal_dopamine_level1.44714698
49MP0004782_abnormal_surfactant_physiolog1.41119842
50MP0008995_early_reproductive_senescence1.40509883
51MP0005636_abnormal_mineral_homeostasis1.40428974
52MP0002396_abnormal_hematopoietic_system1.39529128
53MP0003763_abnormal_thymus_physiology1.38933512
54MP0005394_taste/olfaction_phenotype1.38044649
55MP0005499_abnormal_olfactory_system1.38044649
56MP0008058_abnormal_DNA_repair1.37726284
57MP0002822_catalepsy1.34913491
58MP0003186_abnormal_redox_activity1.33953040
59MP0005174_abnormal_tail_pigmentation1.31169536
60MP0001188_hyperpigmentation1.30224546
61MP0002557_abnormal_social/conspecific_i1.28684672
62MP0008875_abnormal_xenobiotic_pharmacok1.28620127
63MP0005410_abnormal_fertilization1.26656346
64MP0001765_abnormal_ion_homeostasis1.25318002
65MP0004145_abnormal_muscle_electrophysio1.24831050
66MP0001293_anophthalmia1.23849950
67MP0008872_abnormal_physiological_respon1.23631248
68MP0003698_abnormal_male_reproductive1.22989256
69MP0000372_irregular_coat_pigmentation1.22455610
70MP0002234_abnormal_pharynx_morphology1.22169360
71MP0005365_abnormal_bile_salt1.18454156
72MP0002160_abnormal_reproductive_system1.16769511
73MP0001664_abnormal_digestion1.16399829
74MP0001984_abnormal_olfaction1.15799466
75MP0004142_abnormal_muscle_tone1.15539722
76MP0002572_abnormal_emotion/affect_behav1.15492095
77MP0000026_abnormal_inner_ear1.14783704
78MP0003329_amyloid_beta_deposits1.14734385
79MP0003656_abnormal_erythrocyte_physiolo1.14605990
80MP0000955_abnormal_spinal_cord1.14493379
81MP0003195_calcinosis1.13981729
82MP0000613_abnormal_salivary_gland1.13931257
83MP0001929_abnormal_gametogenesis1.13371551
84MP0006082_CNS_inflammation1.13197413
85MP0002210_abnormal_sex_determination1.12764889
86MP0002078_abnormal_glucose_homeostasis1.11249530
87MP0002277_abnormal_respiratory_mucosa1.11179995
88MP0002166_altered_tumor_susceptibility1.10574040
89MP0003121_genomic_imprinting1.07760005
90MP0003879_abnormal_hair_cell1.07083350
91MP0005464_abnormal_platelet_physiology1.06306458
92MP0001502_abnormal_circadian_rhythm1.05961700
93MP0000230_abnormal_systemic_arterial1.04621923
94MP0002928_abnormal_bile_duct1.04615449
95MP0002132_abnormal_respiratory_system1.04499006
96MP0000653_abnormal_sex_gland1.04239563
97MP0000685_abnormal_immune_system1.04190165
98MP0009643_abnormal_urine_homeostasis1.04094124
99MP0010030_abnormal_orbit_morphology1.03198645
100MP0002064_seizures1.02657772
101MP0000631_abnormal_neuroendocrine_gland1.02406106
102MP0005535_abnormal_body_temperature1.02195014
103MP0000778_abnormal_nervous_system1.01875783
104MP0002067_abnormal_sensory_capabilities1.00276601
105MP0004859_abnormal_synaptic_plasticity1.00145714
106MP0001145_abnormal_male_reproductive0.99167848
107MP0000015_abnormal_ear_pigmentation0.98873639
108MP0002736_abnormal_nociception_after0.98636205
109MP0005409_darkened_coat_color0.98298063
110MP0002735_abnormal_chemical_nociception0.98122444
111MP0005389_reproductive_system_phenotype0.97948623
112MP0001835_abnormal_antigen_presentation0.96891066
113MP0002272_abnormal_nervous_system0.95781494
114MP0000465_gastrointestinal_hemorrhage0.95268021
115MP0002876_abnormal_thyroid_physiology0.95139429
116MP0005195_abnormal_posterior_eye0.95080972
117MP0001485_abnormal_pinna_reflex0.93125645
118MP0005584_abnormal_enzyme/coenzyme_acti0.92872034
119MP0002184_abnormal_innervation0.92516708
120MP0005058_abnormal_lysosome_morphology0.92051622
121MP0006276_abnormal_autonomic_nervous0.90977066
122MP0002752_abnormal_somatic_nervous0.90732150
123MP0003953_abnormal_hormone_level0.90541484
124MP0006035_abnormal_mitochondrial_morpho0.90434279
125MP0008569_lethality_at_weaning0.90156654
126MP0003300_gastrointestinal_ulcer0.88865318
127MP0009697_abnormal_copulation0.86374919
128MP0002095_abnormal_skin_pigmentation0.86111010
129MP0001968_abnormal_touch/_nociception0.86050625
130MP0001270_distended_abdomen0.84991788
131MP0002723_abnormal_immune_serum0.84593761
132MP0001666_abnormal_nutrient_absorption0.81739850
133MP0005332_abnormal_amino_acid0.81298937
134MP0005645_abnormal_hypothalamus_physiol0.80214137
135MP0003191_abnormal_cellular_cholesterol0.80170969
136MP0003786_premature_aging0.80147739
137MP0001756_abnormal_urination0.79893207
138MP0004270_analgesia0.79565477
139MP0002229_neurodegeneration0.79174530
140MP0002733_abnormal_thermal_nociception0.78958981
141MP0001663_abnormal_digestive_system0.78536058
142MP0003646_muscle_fatigue0.77181786
143MP0000749_muscle_degeneration0.76848706
144MP0001501_abnormal_sleep_pattern0.76019489
145MP0003718_maternal_effect0.75636492
146MP0001970_abnormal_pain_threshold0.75269551
147MP0002420_abnormal_adaptive_immunity0.73488394
148MP0009765_abnormal_xenobiotic_induced0.72657892
149MP0001346_abnormal_lacrimal_gland0.72585219
150MP0002882_abnormal_neuron_morphology0.72245038
151MP0003638_abnormal_response/metabolism_0.71763294
152MP0003315_abnormal_perineum_morphology0.71654893
153MP0003635_abnormal_synaptic_transmissio0.71639616
154MP0009642_abnormal_blood_homeostasis0.70903444

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.66925404
2Hepatic necrosis (HP:0002605)4.49034447
3Abnormal mitochondria in muscle tissue (HP:0008316)4.42229279
4Mitochondrial inheritance (HP:0001427)4.41769946
5Acute necrotizing encephalopathy (HP:0006965)4.37610628
6Increased intramyocellular lipid droplets (HP:0012240)4.19574375
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.15061038
8Decreased activity of mitochondrial respiratory chain (HP:0008972)4.15061038
9Acute encephalopathy (HP:0006846)4.13247666
10Increased hepatocellular lipid droplets (HP:0006565)3.88168549
11Increased CSF lactate (HP:0002490)3.85607922
12Increased muscle lipid content (HP:0009058)3.74381357
13Lipid accumulation in hepatocytes (HP:0006561)3.63659385
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.62090709
15Hypothermia (HP:0002045)3.59986758
16Renal Fanconi syndrome (HP:0001994)3.54923174
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.48883016
18Progressive macrocephaly (HP:0004481)3.41366731
19Hyperglycinemia (HP:0002154)3.35182825
20Type I transferrin isoform profile (HP:0003642)3.33985745
21Reticulocytopenia (HP:0001896)3.28963165
22Lactic acidosis (HP:0003128)3.24168038
23Abnormal rod and cone electroretinograms (HP:0008323)3.19251603
24Medial flaring of the eyebrow (HP:0010747)3.19058019
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.14558262
26Generalized aminoaciduria (HP:0002909)3.06318429
27Polyphagia (HP:0002591)3.04362240
28Molar tooth sign on MRI (HP:0002419)3.03642865
29Abnormality of midbrain morphology (HP:0002418)3.03642865
30Nephronophthisis (HP:0000090)3.01166081
31Aplastic anemia (HP:0001915)3.00790135
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.98337855
33Gait imbalance (HP:0002141)2.95617334
34Increased serum lactate (HP:0002151)2.92962727
35Congenital stationary night blindness (HP:0007642)2.87898510
36Abnormal protein glycosylation (HP:0012346)2.80818527
37Abnormal glycosylation (HP:0012345)2.80818527
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.80818527
39Abnormal protein N-linked glycosylation (HP:0012347)2.80818527
40Pancreatic fibrosis (HP:0100732)2.78042281
41Cerebral edema (HP:0002181)2.74718267
42Nephrogenic diabetes insipidus (HP:0009806)2.73595376
43Abnormality of renal resorption (HP:0011038)2.73114562
44Ketoacidosis (HP:0001993)2.71231846
45Congenital primary aphakia (HP:0007707)2.70788662
46Exercise intolerance (HP:0003546)2.68221853
47Reduced antithrombin III activity (HP:0001976)2.68210140
483-Methylglutaconic aciduria (HP:0003535)2.65088545
49Hyperphosphaturia (HP:0003109)2.63938078
50Severe visual impairment (HP:0001141)2.61285136
51Progressive neurologic deterioration (HP:0002344)2.59173990
52True hermaphroditism (HP:0010459)2.57905287
53Respiratory failure (HP:0002878)2.57582319
54Exertional dyspnea (HP:0002875)2.56613663
55Myokymia (HP:0002411)2.52657411
56Abnormality of urine glucose concentration (HP:0011016)2.52598886
57Glycosuria (HP:0003076)2.52598886
58Retinal dysplasia (HP:0007973)2.49106989
59Respiratory difficulties (HP:0002880)2.48355676
60Hypoglycemic coma (HP:0001325)2.48326305
61Macrocytic anemia (HP:0001972)2.47686222
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.44320832
63Absent/shortened dynein arms (HP:0200106)2.44320832
64Optic disc pallor (HP:0000543)2.43837504
65Type II lissencephaly (HP:0007260)2.42727348
66Ketosis (HP:0001946)2.39024399
67Bony spicule pigmentary retinopathy (HP:0007737)2.38996088
68IgM deficiency (HP:0002850)2.38729637
69Abnormal biliary tract physiology (HP:0012439)2.37765106
70Bile duct proliferation (HP:0001408)2.37765106
71Abnormal number of erythroid precursors (HP:0012131)2.35625652
72Abnormality of cells of the erythroid lineage (HP:0012130)2.35069511
73Pancreatic cysts (HP:0001737)2.33599816
74Decreased circulating renin level (HP:0003351)2.28164879
75Abnormal delayed hypersensitivity skin test (HP:0002963)2.27887835
76Hypoglycemic seizures (HP:0002173)2.24566511
77Hyperglycinuria (HP:0003108)2.23580649
78Methylmalonic aciduria (HP:0012120)2.23482528
79CNS demyelination (HP:0007305)2.20276640
80Methylmalonic acidemia (HP:0002912)2.19523688
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18491820
82Abnormality of alanine metabolism (HP:0010916)2.18491820
83Hyperalaninemia (HP:0003348)2.18491820
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.17784735
85Poor suck (HP:0002033)2.17025279
86Optic nerve hypoplasia (HP:0000609)2.16802660
87Abnormal respiratory motile cilium physiology (HP:0012261)2.15692861
88Ragged-red muscle fibers (HP:0003200)2.15623492
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.14545002
90Abnormal ciliary motility (HP:0012262)2.14104169
91Abnormality of serine family amino acid metabolism (HP:0010894)2.13987929
92Abnormality of glycine metabolism (HP:0010895)2.13987929
93Emotional lability (HP:0000712)2.12609665
94Colon cancer (HP:0003003)2.12520975
95Progressive microcephaly (HP:0000253)2.11570021
96Polydipsia (HP:0001959)2.11387231
97Abnormal drinking behavior (HP:0030082)2.11387231
98Microvesicular hepatic steatosis (HP:0001414)2.10525005
99Abnormality of the renal medulla (HP:0100957)2.09077331
100Large for gestational age (HP:0001520)2.07785776
101Cortical visual impairment (HP:0100704)2.06667916
102Abnormality of the heme biosynthetic pathway (HP:0010472)2.06617579
103Abolished electroretinogram (ERG) (HP:0000550)2.05900496
104Maternal diabetes (HP:0009800)2.05459960
105Type 2 muscle fiber atrophy (HP:0003554)2.04606943
106Symptomatic seizures (HP:0011145)2.03243187
107Abnormal respiratory motile cilium morphology (HP:0005938)2.02807188
108Abnormal respiratory epithelium morphology (HP:0012253)2.02807188
109Abnormality of cochlea (HP:0000375)1.98785142
110Lethargy (HP:0001254)1.97706935
111Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96905078
112Dicarboxylic aciduria (HP:0003215)1.96905078
113Pancytopenia (HP:0001876)1.96235226
114Atrophy/Degeneration involving motor neurons (HP:0007373)1.94568436
115Abnormal urine phosphate concentration (HP:0012599)1.93751992
116Tubular atrophy (HP:0000092)1.93308163
117Testicular atrophy (HP:0000029)1.93039353
118Panhypogammaglobulinemia (HP:0003139)1.91250634
119Rimmed vacuoles (HP:0003805)1.90557486
120Hyperinsulinemic hypoglycemia (HP:0000825)1.90380716
121Abnormality of DNA repair (HP:0003254)1.89136821
122Degeneration of anterior horn cells (HP:0002398)1.87306213
123Abnormality of the anterior horn cell (HP:0006802)1.87306213
124Oligodactyly (hands) (HP:0001180)1.86814170
125Unsteady gait (HP:0002317)1.86551249
126Metabolic acidosis (HP:0001942)1.86549093
127Muscle fiber atrophy (HP:0100295)1.86116440
128Tubulointerstitial nephritis (HP:0001970)1.85044957
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84874446
130Progressive muscle weakness (HP:0003323)1.81441336
131Elevated erythrocyte sedimentation rate (HP:0003565)1.80889230
132Delusions (HP:0000746)1.80399586
133Visual hallucinations (HP:0002367)1.79256989
134Hypoplasia of the uterus (HP:0000013)1.78603640
135Aplasia/hypoplasia of the uterus (HP:0008684)1.76492691
136Hypoplasia of the thymus (HP:0000778)1.74366790
137Nonprogressive disorder (HP:0003680)1.73746502
138Hyperactive renin-angiotensin system (HP:0000841)1.72539072
139Delayed CNS myelination (HP:0002188)1.71496602
140Late onset (HP:0003584)1.71362892
141Abnormality of T cell physiology (HP:0011840)1.68162361
142Leukodystrophy (HP:0002415)1.66226484
143Dysostosis multiplex (HP:0000943)1.60586166
144Attenuation of retinal blood vessels (HP:0007843)1.60153138
145Flat capital femoral epiphysis (HP:0003370)1.60135598
146Abnormality of the intrinsic pathway (HP:0010989)1.59840830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.24443829
2BCKDK4.17075888
3VRK23.83758331
4MAP4K23.72454344
5INSRR3.36016990
6TNIK3.14480599
7NME23.05689445
8LMTK23.02976903
9CAMKK22.78338360
10MAP3K122.74458480
11FLT32.63701529
12NME12.48152352
13CDK192.41628221
14ERN12.39532896
15MUSK2.34239856
16ZAK2.22390082
17EIF2AK32.01038479
18BMPR1B1.95401377
19TEC1.92371616
20LIMK11.85309680
21MAP4K11.83055619
22TAOK31.82008980
23MAPK131.69165250
24PASK1.61548996
25PRKG21.49760643
26BTK1.47930434
27ZAP701.42684816
28BRSK21.42373733
29RPS6KA41.40444323
30KIT1.38322152
31TXK1.35069003
32MAP2K71.34324786
33MAPKAPK51.34034496
34PHKG21.33576570
35PHKG11.33576570
36HIPK21.32077110
37NTRK31.29878479
38KDR1.29484931
39MAPK151.27177578
40MYLK1.26226428
41TLK11.13925080
42DAPK21.10462776
43SYK1.08800335
44NEK11.08701780
45RAF11.07748990
46MAP3K111.06274820
47NLK1.05945666
48WNK31.05253290
49MARK11.04333203
50RPS6KA51.03944507
51CCNB11.01798287
52MAP3K10.99341905
53EIF2AK10.98798541
54RIPK40.98109747
55CAMK10.97631014
56PKN10.93707677
57WNK40.93408026
58SIK30.90688159
59PRKD30.90252972
60BMPR20.89438911
61SCYL20.89273127
62ACVR1B0.88450452
63NTRK20.87036305
64LRRK20.86053990
65MAP3K40.84667648
66DYRK30.84496291
67ADRBK20.83674208
68MAP2K60.82889443
69VRK10.79822116
70SRPK10.79800269
71GRK70.79760270
72PRKCG0.77093731
73DYRK1B0.75958568
74TAF10.75648146
75PDK20.75485726
76ABL20.74298702
77ARAF0.73464860
78EPHA40.73188705
79FRK0.72744640
80TESK20.72501024
81TNK20.70056191
82MAP3K60.69392850
83GRK60.69287294
84STK110.67708324
85MARK20.67563834
86DAPK10.66637853
87LYN0.64235128
88IRAK30.62996697
89IRAK10.62641114
90DYRK20.62265923
91DAPK30.62027431
92NUAK10.60736989
93PRKCQ0.58886439
94TESK10.58813591
95SIK20.57267502
96CSNK1G10.57218029
97BCR0.56598892
98PRKCE0.56131442
99PIK3CG0.55688249
100PIM20.55185851
101IKBKE0.54550892
102OBSCN0.53368122
103IKBKB0.52619283
104IRAK40.51687118
105LCK0.51432275
106MINK10.48847061
107CSNK1A1L0.48436723
108JAK30.47798511
109WEE10.47736165
110ADRBK10.46971073
111MAP2K40.46274853
112CAMK2G0.46106734
113KSR20.45607896
114MAP2K20.44452117
115DYRK1A0.44198467
116CSNK1A10.43956898
117CSNK2A20.43242583
118CAMK2D0.43147178
119CDK80.42873862
120MAPK40.40932191
121UHMK10.40615875
122PINK10.39837348
123EPHB20.39821520
124TBK10.39415935
125MARK30.38501108
126CAMK2A0.38340211
127FES0.38269711
128AURKA0.38184445
129OXSR10.38131165
130CSNK1G30.37219694
131CAMKK10.37178991
132CSF1R0.36988103
133GRK10.36793336
134ILK0.36647982
135NTRK10.36233760
136BRSK10.34990024
137MAP3K70.34264958
138TYK20.33104921
139PRKCI0.32860320
140CSNK2A10.32453050
141TRIM280.32259588
142MAP3K130.32213498
143KSR10.31995878
144PRKACA0.31523496
145ITK0.31403417
146STK390.31241320
147TAOK20.30891348
148CSNK1G20.30000213
149IRAK20.29790359
150CAMK2B0.28613896
151CASK0.28588159

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.74130205
2Oxidative phosphorylation_Homo sapiens_hsa001903.83622284
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.76373014
4Parkinsons disease_Homo sapiens_hsa050123.34165899
5Ribosome_Homo sapiens_hsa030103.32801058
6Folate biosynthesis_Homo sapiens_hsa007902.75685027
7Alzheimers disease_Homo sapiens_hsa050102.68004659
8Caffeine metabolism_Homo sapiens_hsa002322.26162653
9Sulfur relay system_Homo sapiens_hsa041222.19274021
10Proteasome_Homo sapiens_hsa030502.14885200
11RNA polymerase_Homo sapiens_hsa030202.13951190
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09366019
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08954527
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04785712
15Sulfur metabolism_Homo sapiens_hsa009201.99898533
16Huntingtons disease_Homo sapiens_hsa050161.99527764
17N-Glycan biosynthesis_Homo sapiens_hsa005101.98930693
18Phototransduction_Homo sapiens_hsa047441.96082802
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.93885676
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83590890
21Pyrimidine metabolism_Homo sapiens_hsa002401.72340977
22Vibrio cholerae infection_Homo sapiens_hsa051101.54955575
23Fatty acid elongation_Homo sapiens_hsa000621.53102998
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49019907
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41026969
26Glutathione metabolism_Homo sapiens_hsa004801.37531437
27Purine metabolism_Homo sapiens_hsa002301.35845450
28DNA replication_Homo sapiens_hsa030301.31797471
29Selenocompound metabolism_Homo sapiens_hsa004501.27768317
30Regulation of autophagy_Homo sapiens_hsa041401.27016543
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25293687
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21089530
33Insulin secretion_Homo sapiens_hsa049111.15415226
34Propanoate metabolism_Homo sapiens_hsa006401.14671635
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12734041
36Cardiac muscle contraction_Homo sapiens_hsa042601.06973652
37Mismatch repair_Homo sapiens_hsa034301.06795511
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02953423
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02155687
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01602591
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93854082
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93082831
43Primary immunodeficiency_Homo sapiens_hsa053400.92441049
44Metabolic pathways_Homo sapiens_hsa011000.91117278
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91044906
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.90367923
47Fanconi anemia pathway_Homo sapiens_hsa034600.87325207
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.87234056
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.86831723
50Arachidonic acid metabolism_Homo sapiens_hsa005900.86762911
51Chemical carcinogenesis_Homo sapiens_hsa052040.83233049
52One carbon pool by folate_Homo sapiens_hsa006700.81396730
53Fatty acid metabolism_Homo sapiens_hsa012120.79637785
54Peroxisome_Homo sapiens_hsa041460.79532604
55Taste transduction_Homo sapiens_hsa047420.77519085
56Pancreatic secretion_Homo sapiens_hsa049720.74280592
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73641952
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73017845
59Vitamin B6 metabolism_Homo sapiens_hsa007500.72968481
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.72894425
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72483805
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72252437
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71767861
64Linoleic acid metabolism_Homo sapiens_hsa005910.70786840
65Tyrosine metabolism_Homo sapiens_hsa003500.70555173
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70269454
67Pyruvate metabolism_Homo sapiens_hsa006200.69289403
68Nucleotide excision repair_Homo sapiens_hsa034200.68740167
69Other glycan degradation_Homo sapiens_hsa005110.67664450
70Homologous recombination_Homo sapiens_hsa034400.67625363
71Galactose metabolism_Homo sapiens_hsa000520.67298566
72Phenylalanine metabolism_Homo sapiens_hsa003600.66377298
73RNA degradation_Homo sapiens_hsa030180.66323638
74Amphetamine addiction_Homo sapiens_hsa050310.64092463
75Tryptophan metabolism_Homo sapiens_hsa003800.62680975
76Biosynthesis of amino acids_Homo sapiens_hsa012300.59896354
77Base excision repair_Homo sapiens_hsa034100.55601738
78Serotonergic synapse_Homo sapiens_hsa047260.55225361
79Long-term potentiation_Homo sapiens_hsa047200.54695039
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54458226
81Basal transcription factors_Homo sapiens_hsa030220.53395943
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53174293
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51139654
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50543142
85Circadian entrainment_Homo sapiens_hsa047130.50262415
86Circadian rhythm_Homo sapiens_hsa047100.50102944
87Ether lipid metabolism_Homo sapiens_hsa005650.49940901
88RNA transport_Homo sapiens_hsa030130.49808596
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46769525
90Retinol metabolism_Homo sapiens_hsa008300.46354091
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46117683
92Arginine and proline metabolism_Homo sapiens_hsa003300.45304375
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44212364
94Synaptic vesicle cycle_Homo sapiens_hsa047210.43724222
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43507226
96Thyroid cancer_Homo sapiens_hsa052160.43206942
97Pentose phosphate pathway_Homo sapiens_hsa000300.43087452
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.43055004
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43005227
100Spliceosome_Homo sapiens_hsa030400.42684996
101Olfactory transduction_Homo sapiens_hsa047400.41245827
102Dopaminergic synapse_Homo sapiens_hsa047280.39389689
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38780112
104ABC transporters_Homo sapiens_hsa020100.37060351
105Lysosome_Homo sapiens_hsa041420.36622922
106Fatty acid degradation_Homo sapiens_hsa000710.36272547
107GABAergic synapse_Homo sapiens_hsa047270.35770729
108Morphine addiction_Homo sapiens_hsa050320.33867274
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33260270
110Basal cell carcinoma_Homo sapiens_hsa052170.32515027
111Steroid biosynthesis_Homo sapiens_hsa001000.32284780
112Fructose and mannose metabolism_Homo sapiens_hsa000510.31606807
113Alcoholism_Homo sapiens_hsa050340.31169817
114Glycerolipid metabolism_Homo sapiens_hsa005610.30272887
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30185584
116Hedgehog signaling pathway_Homo sapiens_hsa043400.30089780
117Cocaine addiction_Homo sapiens_hsa050300.29869865
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29092219
119Histidine metabolism_Homo sapiens_hsa003400.28467477
120Non-homologous end-joining_Homo sapiens_hsa034500.28452241
121Sphingolipid metabolism_Homo sapiens_hsa006000.27232675
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27043289
123Butanoate metabolism_Homo sapiens_hsa006500.25523738
124Collecting duct acid secretion_Homo sapiens_hsa049660.24929760
125Carbon metabolism_Homo sapiens_hsa012000.22133117
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21926725
127Renin secretion_Homo sapiens_hsa049240.21835107
128beta-Alanine metabolism_Homo sapiens_hsa004100.20371784
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.20321039
130Nicotine addiction_Homo sapiens_hsa050330.19065746
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18361802
132Type I diabetes mellitus_Homo sapiens_hsa049400.17852958
133Glutamatergic synapse_Homo sapiens_hsa047240.17561989
134Cholinergic synapse_Homo sapiens_hsa047250.17006723

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