TMEM43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of phagocytosis (GO:0050765)4.87709707
2low-density lipoprotein particle clearance (GO:0034383)4.74535499
3keratan sulfate catabolic process (GO:0042340)4.15957588
4collagen fibril organization (GO:0030199)4.06260015
5protein localization to endosome (GO:0036010)3.91901825
6protein heterotrimerization (GO:0070208)3.85635857
7endodermal cell differentiation (GO:0035987)3.69135853
8skin morphogenesis (GO:0043589)3.65552341
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56798951
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56798951
11hemidesmosome assembly (GO:0031581)3.51579159
12protein retention in ER lumen (GO:0006621)3.51347569
13stress fiber assembly (GO:0043149)3.42913673
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40699409
15peptidyl-proline hydroxylation (GO:0019511)3.39747644
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.36233504
17desmosome organization (GO:0002934)3.28889792
18collagen metabolic process (GO:0032963)3.24739658
19apoptotic cell clearance (GO:0043277)3.23130004
20collagen catabolic process (GO:0030574)3.20961301
21type B pancreatic cell proliferation (GO:0044342)3.18910635
22substrate-dependent cell migration (GO:0006929)3.17930720
23positive regulation of blood vessel endothelial cell migration (GO:0043536)3.14647882
24hypotonic response (GO:0006971)3.13037493
25antigen processing and presentation of endogenous antigen (GO:0019883)3.11718713
26multicellular organismal macromolecule metabolic process (GO:0044259)3.10515680
27protein hydroxylation (GO:0018126)3.08403041
28positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03909652
29negative regulation of smooth muscle cell migration (GO:0014912)3.03030607
30barbed-end actin filament capping (GO:0051016)2.98615756
31negative regulation of granulocyte differentiation (GO:0030853)2.97588882
32vascular endothelial growth factor signaling pathway (GO:0038084)2.96667070
33extracellular matrix assembly (GO:0085029)2.96012351
34multicellular organismal metabolic process (GO:0044236)2.94769283
35brown fat cell differentiation (GO:0050873)2.92902624
36multicellular organismal catabolic process (GO:0044243)2.92319025
37positive regulation of endothelial cell apoptotic process (GO:2000353)2.87451820
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.87436732
39tyrosine phosphorylation of STAT protein (GO:0007260)2.86472572
40cellular response to vitamin (GO:0071295)2.85570343
41positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.84038126
42dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83344935
43extracellular matrix disassembly (GO:0022617)2.82464708
44negative regulation of stress fiber assembly (GO:0051497)2.82033723
45basement membrane organization (GO:0071711)2.78818112
46white fat cell differentiation (GO:0050872)2.76005682
47regulation of macrophage cytokine production (GO:0010935)2.74686867
48positive regulation of receptor recycling (GO:0001921)2.74546320
49neutrophil activation involved in immune response (GO:0002283)2.74270688
50axon extension involved in axon guidance (GO:0048846)2.73635346
51neuron projection extension involved in neuron projection guidance (GO:1902284)2.73635346
52wound healing, spreading of epidermal cells (GO:0035313)2.73286620
53negative regulation of chondrocyte differentiation (GO:0032331)2.73068380
54chondrocyte proliferation (GO:0035988)2.72256514
55cell adhesion mediated by integrin (GO:0033627)2.71077304
56fibril organization (GO:0097435)2.69558798
57epithelial cell-cell adhesion (GO:0090136)2.67978599
58Golgi transport vesicle coating (GO:0048200)2.67858136
59COPI coating of Golgi vesicle (GO:0048205)2.67858136
60sequestering of extracellular ligand from receptor (GO:0035581)2.67054059
61cell migration involved in heart development (GO:0060973)2.66832279
62cellular response to interferon-alpha (GO:0035457)2.63750826
63macrophage differentiation (GO:0030225)2.60079494
64positive regulation of macrophage cytokine production (GO:0060907)2.59556982
65definitive hemopoiesis (GO:0060216)2.58947293
66membrane protein ectodomain proteolysis (GO:0006509)2.56402709
67retina vasculature morphogenesis in camera-type eye (GO:0061299)2.56314893
68angiogenesis involved in wound healing (GO:0060055)2.56197033
69focal adhesion assembly (GO:0048041)2.54745531
70cell-substrate adherens junction assembly (GO:0007045)2.54745531
71phagocytosis, recognition (GO:0006910)2.54510065
72negative regulation of fatty acid transport (GO:2000192)2.54428702
73keratinization (GO:0031424)2.54391155
74adherens junction assembly (GO:0034333)2.54053754
75renal filtration (GO:0097205)2.53396682
76cell-substrate junction assembly (GO:0007044)2.53370136
77modulation by symbiont of host defense response (GO:0052031)2.52358232
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52358232
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52358232
80positive regulation by organism of defense response of other organism involved in symbiotic interact2.52358232
81modulation by symbiont of host immune response (GO:0052553)2.52358232
82positive regulation by symbiont of host defense response (GO:0052509)2.52358232
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.51463157
84positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50106115
85regulation of monocyte chemotaxis (GO:0090025)2.49611195
86positive regulation of monocyte chemotaxis (GO:0090026)2.48315952
87hyaluronan catabolic process (GO:0030214)2.48227521
88lipoxygenase pathway (GO:0019372)2.47940292
89regulation of extracellular matrix disassembly (GO:0010715)2.47851446
90cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.47329174
91glomerular filtration (GO:0003094)2.47111395
92negative regulation of anoikis (GO:2000811)2.46964270
93detection of molecule of bacterial origin (GO:0032490)2.45721124
94negative regulation of nitric oxide biosynthetic process (GO:0045019)2.44808999
95positive regulation of Cdc42 GTPase activity (GO:0043089)2.44719289
96regulation of metalloenzyme activity (GO:0048552)2.44565948
97regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.44530358
98wound healing, spreading of cells (GO:0044319)2.44457039
99membrane raft organization (GO:0031579)2.44363856
100peptide cross-linking (GO:0018149)2.43677065
101response to laminar fluid shear stress (GO:0034616)2.42384862
102germ cell migration (GO:0008354)2.41746539
103fibroblast migration (GO:0010761)2.41379497
104heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.41069289
105positive regulation of natural killer cell differentiation (GO:0032825)2.40901984
106positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.40358704
107regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.40032056
108dermatan sulfate biosynthetic process (GO:0030208)2.39915178
109cortical actin cytoskeleton organization (GO:0030866)2.39510438
110retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39215878
111protein localization to cell surface (GO:0034394)2.38637811
112negative regulation of protein localization to plasma membrane (GO:1903077)2.38324896
113regulation of protein heterodimerization activity (GO:0043497)2.37886332
114surfactant homeostasis (GO:0043129)2.37281823
115regulation of cholesterol storage (GO:0010885)2.36190954
116pentose-phosphate shunt (GO:0006098)2.36061599
117positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.35738917
118vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.35318244
119regulation of interferon-beta biosynthetic process (GO:0045357)2.34473168
120embryonic process involved in female pregnancy (GO:0060136)2.33287869
121growth hormone receptor signaling pathway (GO:0060396)2.33212410
122positive regulation of extracellular matrix organization (GO:1903055)2.33054191
123regulation of macrophage chemotaxis (GO:0010758)2.32147916
124negative regulation of erythrocyte differentiation (GO:0045647)2.31128603
125mesodermal cell differentiation (GO:0048333)2.31022597
126regulation of integrin-mediated signaling pathway (GO:2001044)2.30946157
127negative regulation of leukocyte chemotaxis (GO:0002689)2.28869375
128protein maturation by protein folding (GO:0022417)2.28261056
129extracellular matrix organization (GO:0030198)2.28192253
130extracellular structure organization (GO:0043062)2.27153054
131glomerular basement membrane development (GO:0032836)2.26037586
132keratinocyte differentiation (GO:0030216)2.25727134
133response to progesterone (GO:0032570)2.25657943
134positive regulation of osteoblast proliferation (GO:0033690)2.25007806
135regulation of anoikis (GO:2000209)2.24678518
136glycosaminoglycan catabolic process (GO:0006027)2.24583192
137regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.24240945
138epithelial cell differentiation involved in prostate gland development (GO:0060742)2.22929319
139response to peptidoglycan (GO:0032494)2.22462874
140bone trabecula formation (GO:0060346)2.21817627
141maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.21807584
142mesenchymal-epithelial cell signaling (GO:0060638)2.21415318
143extracellular fibril organization (GO:0043206)2.21404698
144dermatan sulfate metabolic process (GO:0030205)2.21335830
145negative regulation of cartilage development (GO:0061037)2.21281888
146chondrocyte development (GO:0002063)2.20977980
147pinocytosis (GO:0006907)2.20743387
148muscle cell migration (GO:0014812)2.20363138
149cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.19290573
150vesicle coating (GO:0006901)2.19086193
151positive regulation of epithelial cell migration (GO:0010634)2.19016580
152detection of other organism (GO:0098543)2.18638060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.18235208
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.16821645
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.03477384
4E2F7_22180533_ChIP-Seq_HELA_Human3.68779990
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.33923814
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.19022780
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96127981
8CLOCK_20551151_ChIP-Seq_293T_Human2.88291676
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.76754218
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.74070641
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.70923168
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63379898
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.51719830
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.37968576
15* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28365995
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19550728
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.13855913
18* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.10528801
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09800185
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.07686592
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.07175547
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.07104200
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07039467
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.98076788
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97916005
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96997968
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92896917
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92896917
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91793010
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89194657
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88378764
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.84384290
33* ELK3_25401928_ChIP-Seq_HUVEC_Human1.81143731
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79216430
35VDR_21846776_ChIP-Seq_THP-1_Human1.71645649
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.68969823
37P63_26484246_Chip-Seq_KERATINOCYTES_Human1.67604237
38ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.67596085
39* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65952841
40* CJUN_26792858_Chip-Seq_BT549_Human1.65595599
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59458546
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.55512913
43GATA1_22025678_ChIP-Seq_K562_Human1.53582443
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.53260733
45ZNF263_19887448_ChIP-Seq_K562_Human1.50352130
46VDR_24763502_ChIP-Seq_THP-1_Human1.47203512
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46665278
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44942400
49* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39033545
50MAF_26560356_Chip-Seq_TH1_Human1.38536618
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38059259
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37955672
53SOX2_20726797_ChIP-Seq_SW620_Human1.36209788
54MYC_22102868_ChIP-Seq_BL_Human1.34303863
55BRD4_25478319_ChIP-Seq_HGPS_Human1.33639342
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.33308777
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.33308777
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31820276
59SPI1_23547873_ChIP-Seq_NB4_Human1.30812990
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28086352
61* ATF3_27146783_Chip-Seq_COLON_Human1.27669095
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27419037
63JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27118488
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27015692
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26799468
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.26724697
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.26021323
68MYB_26560356_Chip-Seq_TH2_Human1.25653562
69KDM2B_26808549_Chip-Seq_DND41_Human1.24893455
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23895187
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23652004
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.22251657
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20017650
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19743777
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.18067602
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17511360
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17256556
78SCL_19346495_ChIP-Seq_HPC-7_Human1.15568093
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15356208
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.14781393
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14157105
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13733273
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12897268
84SPI1_23127762_ChIP-Seq_K562_Human1.12617160
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11200231
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.10678829
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10488013
88TCF7_22412390_ChIP-Seq_EML_Mouse1.07842666
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06947986
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05819347
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05795937
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05667794
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04408876
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02259358
95RACK7_27058665_Chip-Seq_MCF-7_Human1.02150676
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01916069
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01903081
98UTX_26944678_Chip-Seq_JUKART_Human1.00993080
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00501234
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00067579
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99153692
102TP53_22127205_ChIP-Seq_IMR90_Human0.99118211
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98880260
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.98815438
105RUNX_20019798_ChIP-Seq_JUKART_Human0.98003688
106KDM2B_26808549_Chip-Seq_K562_Human0.97459520
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97251237
108PU_27001747_Chip-Seq_BMDM_Mouse0.97251155
109VDR_24787735_ChIP-Seq_THP-1_Human0.96947928
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94174203
111* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94093731
112* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94006859
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93584340
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93392281
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93279986
116* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93160115
117MYB_26560356_Chip-Seq_TH1_Human0.92544129
118LXR_22292898_ChIP-Seq_THP-1_Human0.90634209
119AR_21909140_ChIP-Seq_LNCAP_Human0.90469543
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90303372
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90046060
122TFEB_21752829_ChIP-Seq_HELA_Human0.89084715
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88414749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.71540670
2MP0005275_abnormal_skin_tensile5.04544712
3MP0003705_abnormal_hypodermis_morpholog3.07657207
4MP0003566_abnormal_cell_adhesion2.60897681
5MP0005503_abnormal_tendon_morphology2.59858994
6MP0002060_abnormal_skin_morphology2.31411400
7MP0003279_aneurysm2.19653609
8MP0002796_impaired_skin_barrier2.13107508
9MP0005257_abnormal_intraocular_pressure2.12989128
10MP0001958_emphysema2.12863362
11MP0003436_decreased_susceptibility_to2.10163364
12MP0004272_abnormal_basement_membrane2.08554040
13MP0004185_abnormal_adipocyte_glucose2.04633765
14MP0008260_abnormal_autophagy2.03865800
15MP0005670_abnormal_white_adipose2.00681366
16MP0010352_gastrointestinal_tract_polyps1.98870325
17MP0006054_spinal_hemorrhage1.95059284
18MP0005023_abnormal_wound_healing1.90108665
19MP0001533_abnormal_skeleton_physiology1.80168335
20MP0000343_altered_response_to1.73993080
21MP0005666_abnormal_adipose_tissue1.67088193
22MP0000858_altered_metastatic_potential1.63169729
23MP0010368_abnormal_lymphatic_system1.62260899
24MP0010234_abnormal_vibrissa_follicle1.53999311
25MP0000751_myopathy1.52453615
26MP0003448_altered_tumor_morphology1.49986897
27MP0002933_joint_inflammation1.48617469
28MP0001849_ear_inflammation1.46898177
29MP0003724_increased_susceptibility_to1.46656565
30MP0005501_abnormal_skin_physiology1.46260241
31MP0005076_abnormal_cell_differentiation1.44594174
32MP0002877_abnormal_melanocyte_morpholog1.44432060
33MP0005390_skeleton_phenotype1.41898191
34MP0001835_abnormal_antigen_presentation1.41238614
35MP0001243_abnormal_dermal_layer1.37426424
36MP0003091_abnormal_cell_migration1.36696439
37MP0000013_abnormal_adipose_tissue1.30950797
38MP0003941_abnormal_skin_development1.30464898
39MP0005375_adipose_tissue_phenotype1.30207394
40MP0005508_abnormal_skeleton_morphology1.30051731
41MP0002419_abnormal_innate_immunity1.29820922
42MP0004947_skin_inflammation1.28889751
43MP0009785_altered_susceptibility_to1.26768154
44MP0001542_abnormal_bone_strength1.26679480
45MP0003303_peritoneal_inflammation1.26487824
46MP0002166_altered_tumor_susceptibility1.26477870
47MP0004130_abnormal_muscle_cell1.24303587
48MP0003300_gastrointestinal_ulcer1.22332116
49MP0001216_abnormal_epidermal_layer1.22073788
50MP0005058_abnormal_lysosome_morphology1.20597533
51MP0002396_abnormal_hematopoietic_system1.20508334
52MP0000465_gastrointestinal_hemorrhage1.19570850
53MP0002998_abnormal_bone_remodeling1.18393096
54MP0010307_abnormal_tumor_latency1.17402900
55MP0000685_abnormal_immune_system1.17331076
56MP0003453_abnormal_keratinocyte_physiol1.15821868
57MP0003191_abnormal_cellular_cholesterol1.14079145
58MP0005409_darkened_coat_color1.13268976
59MP0002006_tumorigenesis1.11504245
60MP0009115_abnormal_fat_cell1.09346195
61MP0005164_abnormal_response_to1.09286351
62MP0002148_abnormal_hypersensitivity_rea1.06526378
63MP0002282_abnormal_trachea_morphology1.06320751
64MP0010771_integument_phenotype1.05414192
65MP0004233_abnormal_muscle_weight1.05186200
66MP0001545_abnormal_hematopoietic_system1.04959615
67MP0005397_hematopoietic_system_phenotyp1.04959615
68MP0004858_abnormal_nervous_system1.04468513
69MP0004883_abnormal_blood_vessel1.04011702
70MP0009840_abnormal_foam_cell1.03058996
71MP0003828_pulmonary_edema1.03037383
72MP0001853_heart_inflammation1.02850438
73MP0000733_abnormal_muscle_development1.00970478
74MP0005000_abnormal_immune_tolerance0.99220248
75MP0009384_cardiac_valve_regurgitation0.98909352
76MP0005451_abnormal_body_composition0.97682659
77MP0004808_abnormal_hematopoietic_stem0.97435486
78MP0002295_abnormal_pulmonary_circulatio0.96950729
79MP0005025_abnormal_response_to0.95409685
80MP0010030_abnormal_orbit_morphology0.92411012
81MP0009278_abnormal_bone_marrow0.91474837
82MP0001915_intracranial_hemorrhage0.91048944
83MP0005623_abnormal_meninges_morphology0.90890479
84MP0005595_abnormal_vascular_smooth0.90797086
85MP0001790_abnormal_immune_system0.90414789
86MP0005387_immune_system_phenotype0.90414789
87MP0000767_abnormal_smooth_muscle0.89680782
88MP0003795_abnormal_bone_structure0.88888058
89MP0002254_reproductive_system_inflammat0.88754257
90MP0000163_abnormal_cartilage_morphology0.88521129
91MP0003950_abnormal_plasma_membrane0.88201873
92MP0002452_abnormal_antigen_presenting0.88060712
93MP0000003_abnormal_adipose_tissue0.87811647
94MP0000762_abnormal_tongue_morphology0.87606692
95MP0005464_abnormal_platelet_physiology0.86965455
96MP0000750_abnormal_muscle_regeneration0.86691373
97MP0006138_congestive_heart_failure0.86418295
98MP0003172_abnormal_lysosome_physiology0.86400305
99MP0002405_respiratory_system_inflammati0.85874555
100MP0002133_abnormal_respiratory_system0.85149562
101MP0005388_respiratory_system_phenotype0.85149562
102MP0005165_increased_susceptibility_to0.85136998
103MP0005621_abnormal_cell_physiology0.85094146
104MP0002113_abnormal_skeleton_development0.84847800
105MP0003045_fibrosis0.84167417
106MP0002115_abnormal_skeleton_extremities0.81883578
107MP0004134_abnormal_chest_morphology0.80698502
108MP0009931_abnormal_skin_appearance0.80435423
109MP0002420_abnormal_adaptive_immunity0.77591810
110MP0001819_abnormal_immune_cell0.76770664
111MP0002896_abnormal_bone_mineralization0.75886523
112MP0001879_abnormal_lymphatic_vessel0.75660314
113MP0001851_eye_inflammation0.74778315
114MP0001614_abnormal_blood_vessel0.74611524
115MP0006082_CNS_inflammation0.74435107
116MP0000759_abnormal_skeletal_muscle0.73949141
117MP0000249_abnormal_blood_vessel0.73167834
118MP0002970_abnormal_white_adipose0.72350916
119MP0000467_abnormal_esophagus_morphology0.71647450
120MP0001348_abnormal_lacrimal_gland0.71229168
121MP0000490_abnormal_crypts_of0.71151021
122MP0003329_amyloid_beta_deposits0.70948087
123MP0002108_abnormal_muscle_morphology0.70830258
124MP0010155_abnormal_intestine_physiology0.70785118
125MP0001191_abnormal_skin_condition0.69472283
126MP0001175_abnormal_lung_morphology0.69293506
127MP0009250_abnormal_appendicular_skeleto0.68525594
128MP0004782_abnormal_surfactant_physiolog0.68168632
129MP0003075_altered_response_to0.68161084
130MP0005197_abnormal_uvea_morphology0.67715469
131MP0000604_amyloidosis0.66336813
132MP0005330_cardiomyopathy0.63518785

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.85537402
2Protrusio acetabuli (HP:0003179)4.70492999
3Cervical subluxation (HP:0003308)3.91604008
4Ankle contracture (HP:0006466)3.76119374
5Cerebral aneurysm (HP:0004944)3.23275487
6Atrophic scars (HP:0001075)3.21798782
7Aortic dissection (HP:0002647)3.13733151
8Peritonitis (HP:0002586)3.08520703
9Osteolytic defects of the hand bones (HP:0009699)3.08193444
10Osteolytic defects of the phalanges of the hand (HP:0009771)3.08193444
11Increased connective tissue (HP:0009025)3.03624289
12Soft skin (HP:0000977)2.98876187
13Shallow orbits (HP:0000586)2.85488328
14Vertebral compression fractures (HP:0002953)2.85321783
15Epiphyseal dysplasia (HP:0002656)2.83713327
16Neonatal short-limb short stature (HP:0008921)2.80827751
17Spinal rigidity (HP:0003306)2.79749463
18Acanthosis nigricans (HP:0000956)2.77372123
19Type 1 muscle fiber predominance (HP:0003803)2.76863191
20Follicular hyperkeratosis (HP:0007502)2.74094483
21Dilatation of the ascending aorta (HP:0005111)2.71449981
22Aortic aneurysm (HP:0004942)2.70695532
23Eczematoid dermatitis (HP:0000976)2.62991667
24Cupped ribs (HP:0000887)2.62456543
25Slender build (HP:0001533)2.54697274
26Metaphyseal cupping (HP:0003021)2.44511104
27Broad metatarsal (HP:0001783)2.43915663
28Genu recurvatum (HP:0002816)2.43395087
29Wormian bones (HP:0002645)2.41386905
30Distal lower limb amyotrophy (HP:0008944)2.41239434
31Increased IgE level (HP:0003212)2.39950326
32Mitral regurgitation (HP:0001653)2.37876257
33Blue sclerae (HP:0000592)2.36495151
34Fragile skin (HP:0001030)2.34317096
35Coxa vara (HP:0002812)2.32282853
36Myositis (HP:0100614)2.28749099
37Aneurysm (HP:0002617)2.28563874
38Flat acetabular roof (HP:0003180)2.28350718
39Elevated erythrocyte sedimentation rate (HP:0003565)2.25380030
40Osteoarthritis (HP:0002758)2.24651147
41Abnormal foot bone ossification (HP:0010675)2.24423599
42Abnormality of the calcaneus (HP:0008364)2.20535217
43Mesomelia (HP:0003027)2.19993367
44Natal tooth (HP:0000695)2.19500674
45Mitral stenosis (HP:0001718)2.17692574
46Bladder diverticulum (HP:0000015)2.17505039
47Platyspondyly (HP:0000926)2.16592113
48Joint stiffness (HP:0001387)2.15271079
49Abnormality of the acetabulum (HP:0003170)2.14405309
50Mitral valve prolapse (HP:0001634)2.12270193
51Recurrent abscess formation (HP:0002722)2.11499501
52Wrist flexion contracture (HP:0001239)2.10698184
53Radial bowing (HP:0002986)2.09941898
54Interstitial pulmonary disease (HP:0006530)2.07878449
55Beaking of vertebral bodies (HP:0004568)2.07767484
56Broad face (HP:0000283)2.07731418
57Abnormality of the lumbar spine (HP:0100712)2.05942500
58Ulnar bowing (HP:0003031)2.03116494
59Abnormality of skeletal muscle fiber size (HP:0012084)2.03022898
60Absent frontal sinuses (HP:0002688)2.02729555
61Hyperextensible skin (HP:0000974)2.00767225
62Generalized amyotrophy (HP:0003700)1.99418540
63Decreased skull ossification (HP:0004331)1.98595739
64Increased variability in muscle fiber diameter (HP:0003557)1.97396826
65Vascular tortuosity (HP:0004948)1.96361153
66Ulnar deviation of the wrist (HP:0003049)1.95794877
67Orchitis (HP:0100796)1.95381462
68Delayed cranial suture closure (HP:0000270)1.94779359
69Mild short stature (HP:0003502)1.94322352
70Reduced subcutaneous adipose tissue (HP:0003758)1.94240986
71Disproportionate tall stature (HP:0001519)1.93313999
72Ovoid vertebral bodies (HP:0003300)1.93023439
73Subacute progressive viral hepatitis (HP:0006572)1.90006046
74Irregular epiphyses (HP:0010582)1.89992882
75Scapular winging (HP:0003691)1.88547536
76Increased density of long bones (HP:0006392)1.88080664
77Arterial tortuosity (HP:0005116)1.88025318
78Aortic valve stenosis (HP:0001650)1.87963275
79Abnormal vertebral ossification (HP:0100569)1.86876893
80Hypoplasia of the odontoid process (HP:0003311)1.86435363
81Increased cerebral lipofuscin (HP:0011813)1.85846582
82Abnormal delivery (HP:0001787)1.85693147
83Mildly elevated creatine phosphokinase (HP:0008180)1.85626305
84Syringomyelia (HP:0003396)1.85353271
85Spinal cord lesions (HP:0100561)1.85353271
86Nonimmune hydrops fetalis (HP:0001790)1.85237964
87Abnormality of the odontoid process (HP:0003310)1.84284306
88Biconcave vertebral bodies (HP:0004586)1.83895371
89Thin bony cortex (HP:0002753)1.83794762
90Aortic regurgitation (HP:0001659)1.83289991
91Elbow flexion contracture (HP:0002987)1.80968322
92Thick nail (HP:0001805)1.80881464
93Ectopia lentis (HP:0001083)1.80096472
94Onycholysis (HP:0001806)1.78122456
95Thrombocytosis (HP:0001894)1.78116771
96Hematochezia (HP:0002573)1.77180442
97Abnormality of dentin (HP:0010299)1.76863124
98Short nail (HP:0001799)1.75774974
99Hypoplastic ischia (HP:0003175)1.74221172
100Milia (HP:0001056)1.73222459
101Vertebral hypoplasia (HP:0008417)1.73075836
102Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.73075836
103Entropion (HP:0000621)1.72604171
104Distal lower limb muscle weakness (HP:0009053)1.70310618
105Advanced eruption of teeth (HP:0006288)1.69966322
106Abnormal tarsal ossification (HP:0008369)1.69567217
107Bowing of the arm (HP:0006488)1.69389482
108Bowed forearm bones (HP:0003956)1.69389482
109Joint laxity (HP:0001388)1.69141010
110Difficulty climbing stairs (HP:0003551)1.69019811
111Short clavicles (HP:0000894)1.68769409
112Lower limb amyotrophy (HP:0007210)1.68663962
113Vacuolated lymphocytes (HP:0001922)1.68627563
114Amyloidosis (HP:0011034)1.68244475
115Thin skin (HP:0000963)1.67442987
116Spondylolisthesis (HP:0003302)1.66881766
117Abnormality of oral frenula (HP:0000190)1.66665426
118Overgrowth (HP:0001548)1.66164570
119Abnormality of skull ossification (HP:0002703)1.66113775
120Delayed closure of the anterior fontanelle (HP:0001476)1.66021347
121Alopecia of scalp (HP:0002293)1.65869709
122Polycythemia (HP:0001901)1.65858449
123Increased mean platelet volume (HP:0011877)1.64741050
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63388717
125Upper limb amyotrophy (HP:0009129)1.62418897
126Distal upper limb amyotrophy (HP:0007149)1.62418897
127Abnormality of the distal phalanges of the toes (HP:0010182)1.62407844
128Cellulitis (HP:0100658)1.61520603
129Breech presentation (HP:0001623)1.61278677
130Abnormal platelet volume (HP:0011876)1.61144934
131Glucose intolerance (HP:0000833)1.60966026
132Venous abnormality (HP:0002624)1.60570462
133Striae distensae (HP:0001065)1.60456133
134Dysostosis multiplex (HP:0000943)1.59987571
135Bowel diverticulosis (HP:0005222)1.59054311
136Myocardial infarction (HP:0001658)1.58835774
137Mucopolysacchariduria (HP:0008155)1.58727097
138Urinary glycosaminoglycan excretion (HP:0003541)1.58727097
139Wide anterior fontanel (HP:0000260)1.58120381
140Camptodactyly of toe (HP:0001836)1.57715334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.02440238
2ERN13.32485619
3TTN3.12616998
4TRPM72.73106148
5PRPF4B2.44789611
6PIM22.32148960
7TGFBR22.31909519
8MAP3K32.30809557
9EEF2K2.26886563
10DDR22.26154137
11MAPKAPK32.25115753
12KIT2.03680629
13CAMK1D2.03484846
14LRRK21.91087314
15STK101.87193139
16PKN21.86966563
17MAP2K31.86741549
18RIPK11.86230382
19NEK91.79211429
20MAP3K61.78879293
21PDGFRA1.75317955
22SIK11.71564246
23SMG11.69196018
24PAK41.65864683
25EPHA31.60080352
26RPS6KA41.46748963
27CDK61.46597738
28ICK1.38982060
29TGFBR11.37452329
30MST41.35023705
31ERBB31.34260724
32TBK11.33586993
33NTRK11.27622039
34MST1R1.27398971
35EPHB11.26310426
36FLT31.25740289
37PRKD21.24244283
38CSF1R1.23566134
39EPHB21.22785684
40FER1.21615722
41SIK31.18616461
42LMTK21.17236004
43STK381.15765233
44PTK61.15224697
45KSR21.14023603
46FGFR31.08173347
47TESK11.07651406
48TEC1.07289277
49BLK1.07145588
50TYK21.06910396
51EPHA21.02679510
52ILK1.02514746
53JAK31.02020369
54ZAP701.01142356
55MAP3K101.00553490
56MOS0.98849413
57ARAF0.97124562
58LIMK10.96637992
59MAP3K20.96036763
60TAOK20.95482574
61BRSK20.94978599
62BMX0.94680466
63RPS6KB20.93572723
64JAK10.91205472
65MAP4K10.91001631
66BTK0.90820005
67CDK120.90258920
68PAK20.90196361
69CDC42BPA0.88166307
70LATS10.85828076
71CSK0.83012015
72HCK0.82302145
73PRKG20.82226836
74RAF10.82078019
75CAMK1G0.80985237
76PBK0.80919725
77CAMKK20.80864968
78MAP3K140.77639494
79ITK0.76703521
80MTOR0.76346689
81MAP3K130.74250920
82MET0.72731250
83RPS6KA20.72156746
84PTK20.71844774
85MAP3K10.70320453
86TESK20.69070884
87PDGFRB0.67273811
88ROCK20.66712898
89IKBKB0.66507372
90PIM10.65855708
91FGFR40.65608714
92NEK10.64822462
93NME20.64666452
94MATK0.63752331
95ERBB40.63634782
96MARK20.63524273
97PIK3CG0.63036356
98MYLK0.61474447
99RET0.60375509
100CLK10.60094650
101MAPKAPK20.59111343
102KSR10.58678453
103IRAK40.57671697
104YES10.57344493
105STK240.56505116
106GSK3A0.56253810
107MAPK70.56053789
108SCYL20.55976406
109TIE10.55561721
110IRAK30.52597106
111CHUK0.52463960
112PTK2B0.51711777
113MAP3K80.50871631
114STK30.49816298
115DMPK0.49416547
116RPS6KA60.49376322
117FRK0.49182404
118LCK0.47356052
119EIF2AK20.47249734
120IGF1R0.47103979
121DYRK1B0.46414112
122MAP3K70.45034173
123ABL10.44884010
124CDK90.43769951
125MELK0.43154515
126RPS6KC10.43058611
127RPS6KL10.43058611
128LATS20.42760712
129JAK20.42745316
130CDK40.41770719
131PRKD10.41428238
132ABL20.40060195
133FGFR10.39696440
134SRC0.38741218
135MAP2K10.38540076
136KDR0.37402480
137IKBKE0.37088567
138LYN0.36109605
139CDK70.35227821

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.85668698
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.59575899
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.09509293
4Focal adhesion_Homo sapiens_hsa045102.03419944
5Malaria_Homo sapiens_hsa051442.02475247
6Leishmaniasis_Homo sapiens_hsa051401.88457988
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.84446316
8Lysosome_Homo sapiens_hsa041421.74624626
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.73732382
10Other glycan degradation_Homo sapiens_hsa005111.72616787
11Small cell lung cancer_Homo sapiens_hsa052221.71084891
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.68907521
13Legionellosis_Homo sapiens_hsa051341.63200206
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.60712494
15Proteoglycans in cancer_Homo sapiens_hsa052051.60386633
16Toxoplasmosis_Homo sapiens_hsa051451.57223855
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55301255
18Pertussis_Homo sapiens_hsa051331.54058547
19Phagosome_Homo sapiens_hsa041451.54042133
20Osteoclast differentiation_Homo sapiens_hsa043801.51335531
21p53 signaling pathway_Homo sapiens_hsa041151.47777189
22Amoebiasis_Homo sapiens_hsa051461.46761468
23Apoptosis_Homo sapiens_hsa042101.44875323
24Shigellosis_Homo sapiens_hsa051311.42952759
25Viral myocarditis_Homo sapiens_hsa054161.38638719
26Antigen processing and presentation_Homo sapiens_hsa046121.36816557
27Chronic myeloid leukemia_Homo sapiens_hsa052201.35803948
28Staphylococcus aureus infection_Homo sapiens_hsa051501.32661513
29Adherens junction_Homo sapiens_hsa045201.30761741
30Renal cell carcinoma_Homo sapiens_hsa052111.28885581
31Protein digestion and absorption_Homo sapiens_hsa049741.28661787
32Tuberculosis_Homo sapiens_hsa051521.27667179
33Bladder cancer_Homo sapiens_hsa052191.26208697
34MicroRNAs in cancer_Homo sapiens_hsa052061.23461037
35Endometrial cancer_Homo sapiens_hsa052131.20473444
36Platelet activation_Homo sapiens_hsa046111.20318842
37Pancreatic cancer_Homo sapiens_hsa052121.19804369
38Notch signaling pathway_Homo sapiens_hsa043301.18676524
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18098609
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18035998
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16726671
42TNF signaling pathway_Homo sapiens_hsa046681.14056643
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13568482
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11509129
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09315433
46Pentose phosphate pathway_Homo sapiens_hsa000301.08892759
47Hematopoietic cell lineage_Homo sapiens_hsa046401.08822364
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.07866722
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.07688410
50Measles_Homo sapiens_hsa051621.06788268
51Salmonella infection_Homo sapiens_hsa051321.05447795
52Renin-angiotensin system_Homo sapiens_hsa046141.05064530
53Hepatitis B_Homo sapiens_hsa051611.04733532
54PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04231515
55Caffeine metabolism_Homo sapiens_hsa002321.04017775
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.00737206
57Acute myeloid leukemia_Homo sapiens_hsa052210.98212435
58HTLV-I infection_Homo sapiens_hsa051660.96096875
59Fatty acid biosynthesis_Homo sapiens_hsa000610.96091259
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93220267
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92421783
62TGF-beta signaling pathway_Homo sapiens_hsa043500.91391764
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91316243
64HIF-1 signaling pathway_Homo sapiens_hsa040660.88811082
65Galactose metabolism_Homo sapiens_hsa000520.88237610
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.87710126
67DNA replication_Homo sapiens_hsa030300.87596531
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86334153
69B cell receptor signaling pathway_Homo sapiens_hsa046620.85769585
70N-Glycan biosynthesis_Homo sapiens_hsa005100.83453206
71Rheumatoid arthritis_Homo sapiens_hsa053230.80977524
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.80620840
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79949241
74Sphingolipid metabolism_Homo sapiens_hsa006000.79690729
75AMPK signaling pathway_Homo sapiens_hsa041520.79381400
76mTOR signaling pathway_Homo sapiens_hsa041500.79031769
77Viral carcinogenesis_Homo sapiens_hsa052030.77933555
78Vibrio cholerae infection_Homo sapiens_hsa051100.77882808
79Insulin resistance_Homo sapiens_hsa049310.77368820
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76944491
81Base excision repair_Homo sapiens_hsa034100.76869949
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76215787
83Pathways in cancer_Homo sapiens_hsa052000.75209539
84Prolactin signaling pathway_Homo sapiens_hsa049170.73085095
85Melanoma_Homo sapiens_hsa052180.72115369
86Prion diseases_Homo sapiens_hsa050200.70269825
87PPAR signaling pathway_Homo sapiens_hsa033200.69752911
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69567338
89ErbB signaling pathway_Homo sapiens_hsa040120.69041336
90VEGF signaling pathway_Homo sapiens_hsa043700.67926114
91Hippo signaling pathway_Homo sapiens_hsa043900.66795671
92Herpes simplex infection_Homo sapiens_hsa051680.66290812
93Glioma_Homo sapiens_hsa052140.65461787
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.64650367
95Influenza A_Homo sapiens_hsa051640.64244006
96Colorectal cancer_Homo sapiens_hsa052100.64163501
97Choline metabolism in cancer_Homo sapiens_hsa052310.63548619
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63422056
99Hepatitis C_Homo sapiens_hsa051600.63264795
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.62901514
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62681635
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61976616
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61633337
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61277636
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59582909
106GnRH signaling pathway_Homo sapiens_hsa049120.59320344
107Cell cycle_Homo sapiens_hsa041100.58325082
108Graft-versus-host disease_Homo sapiens_hsa053320.57367387
109Endocytosis_Homo sapiens_hsa041440.57043465
110Arachidonic acid metabolism_Homo sapiens_hsa005900.56897667
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56881098
112Thyroid cancer_Homo sapiens_hsa052160.56863039
113Non-small cell lung cancer_Homo sapiens_hsa052230.56474454
114Chemokine signaling pathway_Homo sapiens_hsa040620.56095083
115Prostate cancer_Homo sapiens_hsa052150.54948389
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54673487
117Insulin signaling pathway_Homo sapiens_hsa049100.53594321
118Rap1 signaling pathway_Homo sapiens_hsa040150.53335103
119Dilated cardiomyopathy_Homo sapiens_hsa054140.52334322
120FoxO signaling pathway_Homo sapiens_hsa040680.51947943

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