TMEM44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.29515032
2neuronal ion channel clustering (GO:0045161)5.25117207
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.24504679
4behavioral response to nicotine (GO:0035095)5.13370170
5vocalization behavior (GO:0071625)4.98222602
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.97406780
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.91952112
8growth hormone secretion (GO:0030252)4.91164340
9synaptic vesicle maturation (GO:0016188)4.90030649
10dendritic spine morphogenesis (GO:0060997)4.82719515
11locomotory exploration behavior (GO:0035641)4.78826326
12spinal cord development (GO:0021510)4.74328709
13regulation of glutamate receptor signaling pathway (GO:1900449)4.61729676
14negative regulation of telomere maintenance (GO:0032205)4.61454563
15glutamate secretion (GO:0014047)4.57532628
16protein localization to synapse (GO:0035418)4.49748690
17positive regulation of growth hormone secretion (GO:0060124)4.49558087
18neurotransmitter-gated ion channel clustering (GO:0072578)4.46827116
19neuron cell-cell adhesion (GO:0007158)4.27250582
20layer formation in cerebral cortex (GO:0021819)4.15785516
21synaptic vesicle exocytosis (GO:0016079)4.14165570
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.07396778
23central nervous system projection neuron axonogenesis (GO:0021952)4.06514821
24regulation of synapse structural plasticity (GO:0051823)4.01568637
25synaptic transmission, glutamatergic (GO:0035249)3.98167109
26regulation of synaptic vesicle exocytosis (GO:2000300)3.90648201
27postsynaptic membrane organization (GO:0001941)3.89770369
28regulation of dendritic spine morphogenesis (GO:0061001)3.88934877
29neuron recognition (GO:0008038)3.87512653
30positive regulation of dendritic spine morphogenesis (GO:0061003)3.85849180
31auditory behavior (GO:0031223)3.81418011
32neuronal action potential propagation (GO:0019227)3.79409491
33regulation of neuronal synaptic plasticity (GO:0048168)3.78831010
34long-term memory (GO:0007616)3.76613576
35negative regulation of catenin import into nucleus (GO:0035414)3.76447573
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.73375018
37axonal fasciculation (GO:0007413)3.71842148
38regulation of cilium movement (GO:0003352)3.70722888
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70675681
40exploration behavior (GO:0035640)3.69360216
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66223434
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.64917095
43response to auditory stimulus (GO:0010996)3.64192222
44positive regulation of gastrulation (GO:2000543)3.62034048
45anterograde synaptic vesicle transport (GO:0048490)3.59404327
46glutamate receptor signaling pathway (GO:0007215)3.58697926
47cellular response to ATP (GO:0071318)3.58302351
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.55946412
49dendrite morphogenesis (GO:0048813)3.55636285
50gamma-aminobutyric acid transport (GO:0015812)3.55029899
51positive regulation of dendritic spine development (GO:0060999)3.53858262
52negative regulation of organelle assembly (GO:1902116)3.51052072
53nephron tubule morphogenesis (GO:0072078)3.49617357
54nephron epithelium morphogenesis (GO:0072088)3.49617357
55cerebral cortex radially oriented cell migration (GO:0021799)3.49201751
56regulation of synaptic vesicle transport (GO:1902803)3.49070475
57neuron-neuron synaptic transmission (GO:0007270)3.49060418
58neurotransmitter secretion (GO:0007269)3.41235450
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40377054
60presynaptic membrane assembly (GO:0097105)3.35726040
61nucleobase catabolic process (GO:0046113)3.35322006
62erythrocyte maturation (GO:0043249)3.34610467
63regulation of cholesterol esterification (GO:0010872)3.33219435
64regulation of microtubule-based movement (GO:0060632)3.32802868
65anatomical structure maturation (GO:0071695)3.31389620
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.30361017
67regulation of dendritic spine development (GO:0060998)3.30199815
68nonmotile primary cilium assembly (GO:0035058)3.30074795
69epithelial cilium movement (GO:0003351)3.29538164
70thalamus development (GO:0021794)3.29486799
71water-soluble vitamin biosynthetic process (GO:0042364)3.24812069
72positive regulation of neurotransmitter secretion (GO:0001956)3.24663626
73cerebral cortex neuron differentiation (GO:0021895)3.20627263
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18414408
75positive regulation of membrane potential (GO:0045838)3.17654123
76central nervous system neuron axonogenesis (GO:0021955)3.15160967
77urinary tract smooth muscle contraction (GO:0014848)3.15017826
78mechanosensory behavior (GO:0007638)3.13523497
79positive regulation of synapse assembly (GO:0051965)3.12994019
80dendritic spine organization (GO:0097061)3.12629397
81platelet dense granule organization (GO:0060155)3.10676828
82regulation of growth hormone secretion (GO:0060123)3.10557555
83transmission of nerve impulse (GO:0019226)3.10213414
84presynaptic membrane organization (GO:0097090)3.09205070
85L-amino acid import (GO:0043092)3.08827119
86cell migration in hindbrain (GO:0021535)3.07498929
87G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.07403011
88positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.06424312
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06075685
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03439005
91regulation of synaptic transmission, glutamatergic (GO:0051966)3.03415714
92regulation of postsynaptic membrane potential (GO:0060078)3.02343117
93myelin assembly (GO:0032288)3.01789485
94head development (GO:0060322)3.01218301
95retinal ganglion cell axon guidance (GO:0031290)2.97279258
96synapse assembly (GO:0007416)2.95730089
97positive regulation of neurotransmitter transport (GO:0051590)2.95581979
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95376304
99regulation of synaptic plasticity (GO:0048167)2.94857425
100negative regulation of axon extension involved in axon guidance (GO:0048843)2.94433125
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94196001
102substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.93505918
103substrate-independent telencephalic tangential migration (GO:0021826)2.93505918
104proline transport (GO:0015824)2.92778433
105regulation of respiratory system process (GO:0044065)2.92540773
106pattern specification involved in kidney development (GO:0061004)2.92112256
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91974801
108regulation of neurotransmitter secretion (GO:0046928)2.91598540
109pyrimidine nucleobase catabolic process (GO:0006208)2.91395383
110renal tubule morphogenesis (GO:0061333)2.89253037
111protein polyglutamylation (GO:0018095)2.89156947
112lysosome localization (GO:0032418)2.89077879
113cell communication by electrical coupling (GO:0010644)2.88922529
114response to pheromone (GO:0019236)2.87575143
115intraciliary transport (GO:0042073)2.86256946
116axonemal dynein complex assembly (GO:0070286)2.86087912
117cilium morphogenesis (GO:0060271)2.85129304
118glial cell proliferation (GO:0014009)2.84484215
119rRNA catabolic process (GO:0016075)2.83464570
120mitochondrial calcium ion transport (GO:0006851)2.83143093
121positive regulation of synapse maturation (GO:0090129)2.82517471
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82375853
123regulation of synapse assembly (GO:0051963)2.82195984
124ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.81971166
125calcium ion import (GO:0070509)2.80923136
126calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.80004414
127learning (GO:0007612)2.79255630
128regulation of synapse organization (GO:0050807)2.79200563
129regulation of action potential (GO:0098900)2.78527094
130adult walking behavior (GO:0007628)2.78379048
131sequestering of actin monomers (GO:0042989)2.77416467
132negative regulation of dendrite development (GO:2000171)2.77330714
133protein-cofactor linkage (GO:0018065)2.75861580
134ubiquinone biosynthetic process (GO:0006744)2.73826058
135neuronal action potential (GO:0019228)2.73730898
136heparin metabolic process (GO:0030202)2.73077870
137heparin biosynthetic process (GO:0030210)2.73077870
138long-term synaptic potentiation (GO:0060291)2.72429594
139cAMP catabolic process (GO:0006198)2.72213859
140negative regulation of axon guidance (GO:1902668)2.72152740
141regulation of respiratory gaseous exchange (GO:0043576)2.69813323
142visual learning (GO:0008542)2.68746452
143phasic smooth muscle contraction (GO:0014821)2.68405343
144neuromuscular process controlling balance (GO:0050885)2.68346369
145positive regulation of action potential (GO:0045760)2.66650510
146regulation of synaptic transmission, GABAergic (GO:0032228)2.66170810
147cornea development in camera-type eye (GO:0061303)2.64803478
148cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.64715396
149negative regulation of multicellular organism growth (GO:0040015)2.61574336
150cilium movement (GO:0003341)2.60907542
151ganglion development (GO:0061548)2.60781807
152positive regulation of oligodendrocyte differentiation (GO:0048714)2.60059031
153cilium or flagellum-dependent cell motility (GO:0001539)2.58290691
154behavioral response to ethanol (GO:0048149)2.57180612
155regulation of telomere maintenance (GO:0032204)2.56104694
156anterograde axon cargo transport (GO:0008089)2.54731927
157glycerophospholipid catabolic process (GO:0046475)2.54300545
158protein insertion into membrane (GO:0051205)2.52482342
159negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.46457090
160ubiquinone metabolic process (GO:0006743)2.45403116
161positive regulation of vesicle fusion (GO:0031340)2.44314106
162positive regulation of protein kinase C signaling (GO:0090037)2.42880473
163protein localization to cilium (GO:0061512)2.42238900
164somite development (GO:0061053)2.41590061
165positive regulation of prostaglandin secretion (GO:0032308)2.40878978
166short-term memory (GO:0007614)2.40060473
167smoothened signaling pathway (GO:0007224)2.39956541
168negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.39608911
169negative regulation of T cell differentiation in thymus (GO:0033085)2.38512610
170axoneme assembly (GO:0035082)2.38298716
171regulation of apoptotic process involved in morphogenesis (GO:1902337)2.37764559
172neuron projection extension involved in neuron projection guidance (GO:1902284)2.37191008
173axon extension involved in axon guidance (GO:0048846)2.37191008
174sulfation (GO:0051923)2.36658964
175cell proliferation in forebrain (GO:0021846)2.36491165
176startle response (GO:0001964)2.35547014
177parturition (GO:0007567)2.35330805
178indolalkylamine metabolic process (GO:0006586)2.35279946
179left/right pattern formation (GO:0060972)2.34248553
180NADH dehydrogenase complex assembly (GO:0010257)2.33669162
181mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.33669162
182mitochondrial respiratory chain complex I assembly (GO:0032981)2.33669162
183photoreceptor cell development (GO:0042461)2.32836718
184facial nerve structural organization (GO:0021612)2.32746349
185lipopolysaccharide biosynthetic process (GO:0009103)2.32437463
186urogenital system development (GO:0001655)2.31984866
187S-adenosylmethionine metabolic process (GO:0046500)2.31955098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99643127
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.64315108
3ZNF274_21170338_ChIP-Seq_K562_Hela3.56953616
4GBX2_23144817_ChIP-Seq_PC3_Human3.51427961
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.40815197
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15320401
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10781201
8EZH2_27304074_Chip-Seq_ESCs_Mouse3.08337652
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.94469146
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.94469146
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.92137666
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.82968554
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.81797567
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.69082935
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68564824
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.59407451
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.57058129
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.49508333
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.46031168
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45153754
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.40397398
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40209633
23DROSHA_22980978_ChIP-Seq_HELA_Human2.39145989
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35151299
25REST_21632747_ChIP-Seq_MESCs_Mouse2.24899545
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11913379
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06187754
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.05270045
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.98499805
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.97817793
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92025412
32AR_21572438_ChIP-Seq_LNCaP_Human1.91868430
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83339622
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.75893757
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.74569116
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73945493
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72390104
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.63623265
39CTCF_27219007_Chip-Seq_Bcells_Human1.58077096
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56862339
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53693834
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.52574608
43E2F1_20622854_ChIP-Seq_HELA_Human1.52186445
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52093899
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50247960
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.50223277
47ERA_21632823_ChIP-Seq_H3396_Human1.48275498
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46689633
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45330053
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44910704
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43388129
52SMAD4_21799915_ChIP-Seq_A2780_Human1.38963404
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.38954703
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.38362761
55IGF1R_20145208_ChIP-Seq_DFB_Human1.36914839
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36794022
57TAF15_26573619_Chip-Seq_HEK293_Human1.36764665
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.34192150
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33136494
60P68_20966046_ChIP-Seq_HELA_Human1.32976696
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.32901472
62* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31738370
63* TP53_22573176_ChIP-Seq_HFKS_Human1.30454840
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.29017633
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27743087
66RNF2_27304074_Chip-Seq_NSC_Mouse1.27412973
67RAC3_21632823_ChIP-Seq_H3396_Human1.26947684
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.26014525
69* TP53_22127205_ChIP-Seq_IMR90_Human1.24893004
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24706132
71MYC_18940864_ChIP-ChIP_HL60_Human1.24648757
72CTCF_20526341_ChIP-Seq_ESCs_Human1.23645819
73* P300_19829295_ChIP-Seq_ESCs_Human1.23511571
74PHF8_20622854_ChIP-Seq_HELA_Human1.22575672
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22283684
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.20671120
77TP53_16413492_ChIP-PET_HCT116_Human1.20189290
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.19358242
79* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16238982
80VDR_22108803_ChIP-Seq_LS180_Human1.15000500
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14759640
82AR_25329375_ChIP-Seq_VCAP_Human1.14658776
83MYC_19829295_ChIP-Seq_ESCs_Human1.13825040
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13564241
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.13497198
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13085358
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11760291
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10837247
89* AR_19668381_ChIP-Seq_PC3_Human1.10725347
90* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08777166
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08549367
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.08064005
93P53_21459846_ChIP-Seq_SAOS-2_Human1.07937499
94BCL6_27268052_Chip-Seq_Bcells_Human1.07789600
95HOXB7_26014856_ChIP-Seq_BT474_Human1.06967828
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06681736
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06547944
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.06181173
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05978380
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05665619
101NANOG_20526341_ChIP-Seq_ESCs_Human1.04963198
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.04522753
103EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04195503
104JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03641903
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03564309
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03362456
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03030844
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02361509
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01757211
110ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01694728
111TAF2_19829295_ChIP-Seq_ESCs_Human1.01637207
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00352077
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00352077
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00331979
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.99401513
116GATA3_21878914_ChIP-Seq_MCF-7_Human0.99033205
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97841096
118OCT4_20526341_ChIP-Seq_ESCs_Human0.97796944
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97549414
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97352462
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97236706
122SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96596734
123TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96278412
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95563694
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95500860
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94818489
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94389833
128STAT3_23295773_ChIP-Seq_U87_Human0.94269453
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94219920
130AHR_22903824_ChIP-Seq_MCF-7_Human0.93785394
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93739514
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.93245939
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93117772
134OCT4_19829295_ChIP-Seq_ESCs_Human0.92633932
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92374587
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91982957
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91222141
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91177521
139RUNX2_22187159_ChIP-Seq_PCA_Human0.91148239
140* FOXP1_21924763_ChIP-Seq_HESCs_Human0.91000014
141TP53_18474530_ChIP-ChIP_U2OS_Human0.90807155
142* TP53_23651856_ChIP-Seq_MEFs_Mouse0.89752191
143TCF4_23295773_ChIP-Seq_U87_Human0.89460291
144ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89356856
145IRF1_19129219_ChIP-ChIP_H3396_Human0.89250093
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89128625
147KDM2B_26808549_Chip-Seq_K562_Human0.88885852
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88174004
149CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87814199
150P300_27268052_Chip-Seq_Bcells_Human0.87604862
151POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87436294
152POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87329880
153ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87050847
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.86817558
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.85559581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.34116998
2MP0003880_abnormal_central_pattern4.53984992
3MP0003635_abnormal_synaptic_transmissio3.36392472
4MP0005084_abnormal_gallbladder_morpholo3.07346673
5MP0002063_abnormal_learning/memory/cond3.06799318
6MP0002102_abnormal_ear_morphology3.01132408
7MP0000013_abnormal_adipose_tissue2.98606064
8MP0004270_analgesia2.92393937
9MP0009745_abnormal_behavioral_response2.75880441
10MP0001486_abnormal_startle_reflex2.72143951
11MP0002572_abnormal_emotion/affect_behav2.67529351
12MP0005423_abnormal_somatic_nervous2.62602527
13MP0010030_abnormal_orbit_morphology2.49934048
14MP0001968_abnormal_touch/_nociception2.46795070
15MP0002938_white_spotting2.35187179
16MP0002064_seizures2.33286795
17MP0002822_catalepsy2.29195868
18MP0000778_abnormal_nervous_system2.28510880
19MP0005646_abnormal_pituitary_gland2.19838865
20MP0005503_abnormal_tendon_morphology2.11819892
21MP0002734_abnormal_mechanical_nocicepti2.11590046
22MP0001986_abnormal_taste_sensitivity2.11058527
23MP0005377_hearing/vestibular/ear_phenot2.06902469
24MP0003878_abnormal_ear_physiology2.06902469
25MP0009046_muscle_twitch1.98116097
26MP0002272_abnormal_nervous_system1.90777432
27MP0006292_abnormal_olfactory_placode1.89412164
28MP0002557_abnormal_social/conspecific_i1.83365659
29MP0002067_abnormal_sensory_capabilities1.81550351
30MP0003879_abnormal_hair_cell1.79771955
31MP0002735_abnormal_chemical_nociception1.78456393
32MP0002138_abnormal_hepatobiliary_system1.76982597
33MP0009384_cardiac_valve_regurgitation1.75478291
34MP0001440_abnormal_grooming_behavior1.73446017
35MP0005645_abnormal_hypothalamus_physiol1.70577611
36MP0003123_paternal_imprinting1.67532756
37MP0002736_abnormal_nociception_after1.66690513
38MP0008875_abnormal_xenobiotic_pharmacok1.66092151
39MP0006276_abnormal_autonomic_nervous1.65757830
40MP0001485_abnormal_pinna_reflex1.64271598
41MP0004133_heterotaxia1.64010897
42MP0008775_abnormal_heart_ventricle1.61436419
43MP0004742_abnormal_vestibular_system1.58823763
44MP0002184_abnormal_innervation1.58673479
45MP0010368_abnormal_lymphatic_system1.58154924
46MP0001270_distended_abdomen1.56928675
47MP0002653_abnormal_ependyma_morphology1.56462947
48MP0001188_hyperpigmentation1.52388229
49MP0001299_abnormal_eye_distance/1.52050562
50MP0002733_abnormal_thermal_nociception1.51500111
51MP0003787_abnormal_imprinting1.49079405
52MP0002928_abnormal_bile_duct1.48804172
53MP0002876_abnormal_thyroid_physiology1.46596271
54MP0000569_abnormal_digit_pigmentation1.42972419
55MP0004858_abnormal_nervous_system1.41239229
56MP0004811_abnormal_neuron_physiology1.41146885
57MP0000955_abnormal_spinal_cord1.38446068
58MP0001970_abnormal_pain_threshold1.37959444
59MP0002882_abnormal_neuron_morphology1.36151163
60MP0001501_abnormal_sleep_pattern1.36097445
61MP0004924_abnormal_behavior1.32971516
62MP0005386_behavior/neurological_phenoty1.32971516
63MP0002932_abnormal_joint_morphology1.30801574
64MP0008569_lethality_at_weaning1.29957696
65MP0001502_abnormal_circadian_rhythm1.25670663
66MP0000566_synostosis1.25569674
67MP0002837_dystrophic_cardiac_calcinosis1.24079397
68MP0005257_abnormal_intraocular_pressure1.23471597
69MP0000427_abnormal_hair_cycle1.23249646
70MP0002152_abnormal_brain_morphology1.22197445
71MP0000751_myopathy1.21049080
72MP0009780_abnormal_chondrocyte_physiolo1.20861727
73MP0002163_abnormal_gland_morphology1.20844639
74MP0001984_abnormal_olfaction1.20469801
75MP0003942_abnormal_urinary_system1.19819298
76MP0005195_abnormal_posterior_eye1.19725571
77MP0000631_abnormal_neuroendocrine_gland1.19517858
78MP0003279_aneurysm1.18387902
79MP0003121_genomic_imprinting1.17600230
80MP0002066_abnormal_motor_capabilities/c1.15586839
81MP0004885_abnormal_endolymph1.14766122
82MP0001529_abnormal_vocalization1.14014987
83MP0008872_abnormal_physiological_respon1.12484758
84MP0002751_abnormal_autonomic_nervous1.12312044
85MP0005623_abnormal_meninges_morphology1.11671203
86MP0005670_abnormal_white_adipose1.10995331
87MP0004043_abnormal_pH_regulation1.10532775
88MP0005499_abnormal_olfactory_system1.08809078
89MP0005394_taste/olfaction_phenotype1.08809078
90MP0002234_abnormal_pharynx_morphology1.08077151
91MP0003252_abnormal_bile_duct1.07592312
92MP0002249_abnormal_larynx_morphology1.07163748
93MP0003195_calcinosis1.06088181
94MP0000049_abnormal_middle_ear1.05667121
95MP0000230_abnormal_systemic_arterial1.05665110
96MP0005409_darkened_coat_color1.04643754
97MP0003755_abnormal_palate_morphology1.04281065
98MP0001963_abnormal_hearing_physiology1.03711332
99MP0002909_abnormal_adrenal_gland1.02108107
100MP0003633_abnormal_nervous_system1.01979137
101MP0003122_maternal_imprinting1.01698784
102MP0004272_abnormal_basement_membrane0.99588054
103MP0005167_abnormal_blood-brain_barrier0.99139438
104MP0005171_absent_coat_pigmentation0.98716513
105MP0004215_abnormal_myocardial_fiber0.97454013
106MP0002638_abnormal_pupillary_reflex0.97070408
107MP0001177_atelectasis0.96547358
108MP0006072_abnormal_retinal_apoptosis0.95567232
109MP0008877_abnormal_DNA_methylation0.95393094
110MP0000026_abnormal_inner_ear0.94751970
111MP0001664_abnormal_digestion0.93209414
112MP0003861_abnormal_nervous_system0.91759474
113MP0005508_abnormal_skeleton_morphology0.91703920
114MP0001905_abnormal_dopamine_level0.91681939
115MP0003137_abnormal_impulse_conducting0.91454365
116MP0004085_abnormal_heartbeat0.90387954
117MP0005083_abnormal_biliary_tract0.89859906
118MP0000003_abnormal_adipose_tissue0.88769468
119MP0003136_yellow_coat_color0.88451751
120MP0002233_abnormal_nose_morphology0.87915474
121MP0005551_abnormal_eye_electrophysiolog0.87828680
122MP0001286_abnormal_eye_development0.86628502
123MP0005174_abnormal_tail_pigmentation0.85405434
124MP0003938_abnormal_ear_development0.84292913
125MP0000613_abnormal_salivary_gland0.83942850
126MP0002752_abnormal_somatic_nervous0.83418264
127MP0003631_nervous_system_phenotype0.83345217
128MP0003937_abnormal_limbs/digits/tail_de0.82763718
129MP0001879_abnormal_lymphatic_vessel0.82417107
130MP0001944_abnormal_pancreas_morphology0.80963634
131MP0003385_abnormal_body_wall0.78666240
132MP0003329_amyloid_beta_deposits0.75997307
133MP0002069_abnormal_eating/drinking_beha0.74294101
134MP0010386_abnormal_urinary_bladder0.74272868
135MP0003283_abnormal_digestive_organ0.73804191
136MP0008789_abnormal_olfactory_epithelium0.72074675
137MP0003119_abnormal_digestive_system0.71937267
138MP0004142_abnormal_muscle_tone0.70874140
139MP0005248_abnormal_Harderian_gland0.65300076
140MP0002081_perinatal_lethality0.64776360
141MP0000537_abnormal_urethra_morphology0.64465627
142MP0001943_abnormal_respiration0.63224720
143MP0008995_early_reproductive_senescence0.60494789
144MP0002082_postnatal_lethality0.59863493
145MP0010770_preweaning_lethality0.59863493
146MP0009250_abnormal_appendicular_skeleto0.59182302
147MP0010769_abnormal_survival0.57520570

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.64115035
2Type II lissencephaly (HP:0007260)4.91758914
3Myokymia (HP:0002411)4.85595347
4Epileptic encephalopathy (HP:0200134)4.12377913
5Febrile seizures (HP:0002373)4.09909402
6Entropion (HP:0000621)4.01996234
7Poor eye contact (HP:0000817)4.01753269
8Cerebellar dysplasia (HP:0007033)3.98291132
9Focal seizures (HP:0007359)3.97352597
10Megalencephaly (HP:0001355)3.83952939
11Abnormality of midbrain morphology (HP:0002418)3.73259578
12Molar tooth sign on MRI (HP:0002419)3.73259578
13Nephronophthisis (HP:0000090)3.58940590
14Delayed CNS myelination (HP:0002188)3.57588861
15Poikiloderma (HP:0001029)3.57431095
16Pancreatic fibrosis (HP:0100732)3.51282102
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.50279835
18Pancreatic cysts (HP:0001737)3.48393640
19Fragile nails (HP:0001808)3.48043585
20Abnormality of DNA repair (HP:0003254)3.43895177
21Abnormality of the metopic suture (HP:0005556)3.42688289
22Prominent metopic ridge (HP:0005487)3.39272879
23Retinal dysplasia (HP:0007973)3.37861526
24Broad-based gait (HP:0002136)3.29739915
25True hermaphroditism (HP:0010459)3.27836366
26Impaired social interactions (HP:0000735)3.16598410
27Abnormal social behavior (HP:0012433)3.16598410
28Stridor (HP:0010307)3.14339424
29Rib fusion (HP:0000902)3.07819280
30Abnormality of the renal medulla (HP:0100957)3.03953115
31Sclerocornea (HP:0000647)2.99236869
32Lissencephaly (HP:0001339)2.91710163
33Medial flaring of the eyebrow (HP:0010747)2.90716512
34Cystic liver disease (HP:0006706)2.87449027
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.85654934
36Keratoconus (HP:0000563)2.78469238
37Increased corneal curvature (HP:0100692)2.78469238
38Hyperventilation (HP:0002883)2.76771003
39Stereotypic behavior (HP:0000733)2.75388900
40Atonic seizures (HP:0010819)2.75292121
41Limb dystonia (HP:0002451)2.71831445
42Progressive cerebellar ataxia (HP:0002073)2.68993820
43Pachygyria (HP:0001302)2.67385255
44Tubular atrophy (HP:0000092)2.66492872
45Aplasia involving bones of the extremities (HP:0009825)2.64340188
46Aplasia involving bones of the upper limbs (HP:0009823)2.64340188
47Aplasia of the phalanges of the hand (HP:0009802)2.64340188
48Pendular nystagmus (HP:0012043)2.61935648
49Failure to thrive in infancy (HP:0001531)2.61126408
50Abnormal number of erythroid precursors (HP:0012131)2.58924541
51Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.57249275
52Gait imbalance (HP:0002141)2.53818171
53Hemiparesis (HP:0001269)2.49074872
54Agitation (HP:0000713)2.46553354
55Decreased subcutaneous fat (HP:0001002)2.46497981
56Congenital stationary night blindness (HP:0007642)2.46073225
57Occipital encephalocele (HP:0002085)2.45127256
58Methylmalonic acidemia (HP:0002912)2.42923124
59Hyperglycinemia (HP:0002154)2.42179710
60Generalized tonic-clonic seizures (HP:0002069)2.38550606
61Thickened helices (HP:0000391)2.37321929
62Fetal akinesia sequence (HP:0001989)2.37122996
63Morphological abnormality of the middle ear (HP:0008609)2.36156918
64Polyphagia (HP:0002591)2.36109567
65Abnormal respiratory epithelium morphology (HP:0012253)2.35836503
66Abnormal respiratory motile cilium morphology (HP:0005938)2.35836503
67Abnormal rod and cone electroretinograms (HP:0008323)2.34802885
68Abnormality of the renal cortex (HP:0011035)2.34782927
69Visual hallucinations (HP:0002367)2.34615782
70Abnormality of cells of the erythroid lineage (HP:0012130)2.34070191
71Stomach cancer (HP:0012126)2.33589074
72High anterior hairline (HP:0009890)2.33118365
73Drooling (HP:0002307)2.32555120
74Excessive salivation (HP:0003781)2.32555120
75Amblyopia (HP:0000646)2.30801440
76Congenital primary aphakia (HP:0007707)2.29530458
77Deeply set eye (HP:0000490)2.29054085
78Abnormal pancreas size (HP:0012094)2.28505009
79Anencephaly (HP:0002323)2.27037381
80Anterior segment dysgenesis (HP:0007700)2.26310347
81Absence seizures (HP:0002121)2.25583134
82Inability to walk (HP:0002540)2.24328510
83Abnormal eating behavior (HP:0100738)2.22579212
84Ankle clonus (HP:0011448)2.21030113
85Recurrent corneal erosions (HP:0000495)2.18297552
86Elfin facies (HP:0004428)2.18137561
87Abnormality of lateral ventricle (HP:0030047)2.18003661
88Bulbous nose (HP:0000414)2.17539959
89Overgrowth (HP:0001548)2.15922057
90Hypoplasia of the pons (HP:0012110)2.15177596
91Postaxial foot polydactyly (HP:0001830)2.14899584
92Mutism (HP:0002300)2.13051509
93Dialeptic seizures (HP:0011146)2.12766198
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12287417
95Short 4th metacarpal (HP:0010044)2.12287417
96Epileptiform EEG discharges (HP:0011182)2.11950571
97Gaze-evoked nystagmus (HP:0000640)2.11651374
98Anophthalmia (HP:0000528)2.11644739
99Bilateral microphthalmos (HP:0007633)2.10824398
100Abolished electroretinogram (ERG) (HP:0000550)2.09330088
101Adrenal hypoplasia (HP:0000835)2.07910228
102Progressive inability to walk (HP:0002505)2.07537392
103Severe muscular hypotonia (HP:0006829)2.06671907
104EEG with generalized epileptiform discharges (HP:0011198)2.05618104
105Nephrogenic diabetes insipidus (HP:0009806)2.05555238
106Torticollis (HP:0000473)2.05258726
107Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05098896
108Dicarboxylic aciduria (HP:0003215)2.05098896
109Hypoplasia of the brainstem (HP:0002365)2.04923655
110Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04923655
111Septo-optic dysplasia (HP:0100842)2.04480652
112Aplasia/Hypoplasia of the patella (HP:0006498)2.04288185
113Obstructive sleep apnea (HP:0002870)2.03583982
114Patellar aplasia (HP:0006443)2.03209315
115Hypsarrhythmia (HP:0002521)2.02810351
116Brittle hair (HP:0002299)2.01241059
117Methylmalonic aciduria (HP:0012120)2.00961741
118Anxiety (HP:0000739)2.00693562
119Optic nerve hypoplasia (HP:0000609)1.99616699
120Dynein arm defect of respiratory motile cilia (HP:0012255)1.99432875
121Absent/shortened dynein arms (HP:0200106)1.99432875
122Exotropia (HP:0000577)1.98774085
123Cervical subluxation (HP:0003308)1.98418743
124Erythroderma (HP:0001019)1.96471732
125Acute necrotizing encephalopathy (HP:0006965)1.95885431
126Lower limb asymmetry (HP:0100559)1.95858931
127Cutaneous finger syndactyly (HP:0010554)1.95033267
128Bony spicule pigmentary retinopathy (HP:0007737)1.93181240
129Supranuclear gaze palsy (HP:0000605)1.92341120
130Attenuation of retinal blood vessels (HP:0007843)1.91537559
131Narrow nasal bridge (HP:0000446)1.91441409
132Action tremor (HP:0002345)1.90623453
133Mitochondrial inheritance (HP:0001427)1.89759807
134Abnormality of the pons (HP:0007361)1.89750264
135Autism (HP:0000717)1.88563442
136Optic nerve coloboma (HP:0000588)1.86357155
137Chronic hepatic failure (HP:0100626)1.86202669
138Polymicrogyria (HP:0002126)1.85905944
139Dandy-Walker malformation (HP:0001305)1.85545828
140Hepatocellular necrosis (HP:0001404)1.84744174
141Retinitis pigmentosa (HP:0000510)1.84730107
142Depression (HP:0000716)1.84623692
143Cone-rod dystrophy (HP:0000548)1.84621642
144Protruding tongue (HP:0010808)1.83174918
145Abnormality of the 4th metacarpal (HP:0010012)1.83077142
146Insomnia (HP:0100785)1.81900699
147Split foot (HP:0001839)1.81589392
148Pointed chin (HP:0000307)1.81099950
149Impaired vibration sensation in the lower limbs (HP:0002166)1.80824724
150Scrotal hypoplasia (HP:0000046)1.80308159
151Death in childhood (HP:0003819)1.79636598
152Abnormality of the septum pellucidum (HP:0007375)1.79337563
153Hemiplegia (HP:0002301)1.78735136
154Diplopia (HP:0000651)1.78242721
155Abnormality of binocular vision (HP:0011514)1.78242721
156Cutaneous syndactyly (HP:0012725)1.77272161
157Megalocornea (HP:0000485)1.75299635
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.74825997
159Impulsivity (HP:0100710)1.74807214
160Abdominal situs inversus (HP:0003363)1.74186748
161Abnormality of abdominal situs (HP:0011620)1.74186748
162Disproportionate short-trunk short stature (HP:0003521)1.73948330
163Postaxial hand polydactyly (HP:0001162)1.73447048
164Focal dystonia (HP:0004373)1.73445814
165Aortic regurgitation (HP:0001659)1.72687379
166Joint stiffness (HP:0001387)1.72680399
167Meningocele (HP:0002435)1.71743102
168Stage 5 chronic kidney disease (HP:0003774)1.71600945
169Absent speech (HP:0001344)1.71498570
170Ectropion (HP:0000656)1.71493895
171Palpebral edema (HP:0100540)1.71272766
172Urinary bladder sphincter dysfunction (HP:0002839)1.69805107
173Aplasia/Hypoplasia of the spleen (HP:0010451)1.69469153
174Lower limb amyotrophy (HP:0007210)1.69318725
175Annular pancreas (HP:0001734)1.68533626
176Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67256455
177Decreased central vision (HP:0007663)1.67203517
178Congenital hepatic fibrosis (HP:0002612)1.66685766
179Abnormality of salivation (HP:0100755)1.66119984
180Hyperacusis (HP:0010780)1.66080573
181Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66034328
182Subacute progressive viral hepatitis (HP:0006572)1.66007871
183Vaginal atresia (HP:0000148)1.65764873
184Arnold-Chiari malformation (HP:0002308)1.64654195
185J-shaped sella turcica (HP:0002680)1.64421558
186Dysdiadochokinesis (HP:0002075)1.62905974
187Genetic anticipation (HP:0003743)1.62065195
188Incomplete penetrance (HP:0003829)1.62010650
189Sleep apnea (HP:0010535)1.61319956
190Germ cell neoplasia (HP:0100728)1.60866047
191Prolonged QT interval (HP:0001657)1.60326601
192Tracheomalacia (HP:0002779)1.58723627
193Fibular aplasia (HP:0002990)1.57292424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.83628349
2MARK14.58070185
3NTRK33.63518716
4WNK43.45889334
5CASK3.22447196
6ADRBK22.73557724
7IRAK22.64371379
8FRK2.62138819
9DAPK22.61456523
10TLK12.57554249
11TNIK2.52864383
12NTRK22.38121941
13PINK12.30653878
14MAP3K92.21318194
15VRK22.20770171
16MAPK132.20561327
17MAP2K72.15485257
18ZAK2.14711068
19TAOK32.03728032
20MAP3K42.00261594
21GRK11.99582007
22MINK11.95893467
23MAPK151.84687533
24MAPKAPK31.78780544
25PRKD31.76582272
26ICK1.75139500
27EPHA21.73806311
28CDK191.72634457
29TAOK11.71643234
30KSR11.64615363
31PRPF4B1.59593655
32SIK21.55439578
33CAMKK11.50103281
34CDK51.47196494
35PHKG21.43730635
36PHKG11.43730635
37WNK31.40290488
38PAK61.39344837
39TIE11.39336680
40ADRBK11.33386040
41MKNK21.33342450
42INSRR1.32425558
43LIMK11.31423305
44STK161.31221154
45CSNK1G31.27714997
46NEK21.24371729
47TYRO31.24199884
48BRAF1.21903036
49DAPK11.21186849
50UHMK11.20631408
51CSNK1A1L1.20253224
52BCKDK1.20138374
53MAP2K61.19798894
54STK391.18866310
55KDR1.15330701
56NME11.13890902
57FLT31.12412953
58PLK21.11994459
59EPHB21.10008578
60NEK61.05520526
61ERBB31.03238330
62PRKCG1.02274804
63SGK2231.01104147
64SGK4941.01104147
65MAP4K20.99775087
66SGK20.99767884
67BRSK20.94761450
68DMPK0.93764579
69DYRK20.91537066
70MAP2K20.89438786
71PIK3CA0.88531681
72RPS6KA20.88061048
73MAP2K40.86912507
74MET0.86083590
75MAP3K110.85795182
76NUAK10.85726737
77STK110.85724546
78PRKCI0.84320509
79RIPK40.83380489
80LMTK20.81918570
81SIK30.81649303
82MST1R0.79769489
83CAMK2A0.79638498
84BMPR20.79102906
85MAP3K120.77434132
86FES0.76691013
87CCNB10.76151179
88STK380.76067315
89PRKCE0.75254516
90DYRK1A0.75085074
91CSNK1G10.74073948
92CDK180.73328466
93BCR0.73026667
94CAMK1D0.72255780
95CDC42BPA0.72234362
96GRK50.71562826
97MARK20.71274341
98CAMK10.70647206
99VRK10.70564851
100SGK10.70498010
101TGFBR10.68707660
102CDK150.68394932
103BMPR1B0.67724971
104MAP3K60.66528595
105CDK140.66506478
106TESK20.65755140
107CAMK1G0.65050772
108CHEK20.63659975
109CAMK40.62623205
110CDK11A0.62133085
111SGK30.60569198
112NTRK10.60460952
113MAPKAPK50.59679200
114PKN10.59383181
115CAMK2B0.58873439
116TNK20.57625449
117MKNK10.56783575
118BRD40.56309338
119FGFR20.55132163
120PRKCZ0.54457581
121MAP3K70.53751112
122AURKA0.53018739
123TXK0.52681406
124MAPK120.51250032
125PTK2B0.50903887
126OXSR10.50832503
127PAK30.50203748
128PRKD20.49976880
129CLK10.49546006
130ERBB20.49269105
131PRKCH0.47969804
132CAMKK20.47763941
133KIT0.46129682
134DDR20.45708748
135ROCK10.45532158
136CHUK0.43733220
137LATS20.43486201
138MAPK70.43480188
139PTK20.43421042
140CSNK1G20.42536644
141IRAK30.42340949
142KSR20.41905190
143CSNK1A10.41096661
144CSNK1E0.40908519
145TRIM280.40772077
146AKT30.40577034
147TGFBR20.40453155
148PDPK10.39241228
149RPS6KA60.38696547
150PRKG10.38350399
151CSNK1D0.38212817
152ABL20.36289435
153MUSK0.36178659
154CDK80.35964700
155RPS6KA30.35248610
156PRKAA10.34250865
157TESK10.34067147
158PRKACA0.33789606
159PNCK0.33144374
160GRK70.32803862
161DAPK30.32710770
162PDK10.31946767
163PIM20.31643533
164STK38L0.31490555
165WNK10.30494605

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.49884130
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.05246691
3Olfactory transduction_Homo sapiens_hsa047402.60473392
4Glutamatergic synapse_Homo sapiens_hsa047242.50758985
5Circadian entrainment_Homo sapiens_hsa047132.48505802
6Morphine addiction_Homo sapiens_hsa050322.46627693
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45852304
8Synaptic vesicle cycle_Homo sapiens_hsa047212.45197714
9GABAergic synapse_Homo sapiens_hsa047272.39054907
10Oxidative phosphorylation_Homo sapiens_hsa001902.32936418
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32254341
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32160084
13Long-term potentiation_Homo sapiens_hsa047202.13567852
14RNA polymerase_Homo sapiens_hsa030202.13040023
15Axon guidance_Homo sapiens_hsa043602.11478615
16Amphetamine addiction_Homo sapiens_hsa050312.07928861
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03973432
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.02295777
19Sulfur relay system_Homo sapiens_hsa041221.96970405
20Dopaminergic synapse_Homo sapiens_hsa047281.89965539
21Cholinergic synapse_Homo sapiens_hsa047251.86755474
22Linoleic acid metabolism_Homo sapiens_hsa005911.84563773
23Parkinsons disease_Homo sapiens_hsa050121.84234507
24Salivary secretion_Homo sapiens_hsa049701.84029419
25Insulin secretion_Homo sapiens_hsa049111.82645963
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75934609
27Oxytocin signaling pathway_Homo sapiens_hsa049211.75647320
28Cocaine addiction_Homo sapiens_hsa050301.75301568
29ECM-receptor interaction_Homo sapiens_hsa045121.70590405
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68347178
31Butanoate metabolism_Homo sapiens_hsa006501.66800963
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.63464431
33Taste transduction_Homo sapiens_hsa047421.61520558
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59702796
35Gastric acid secretion_Homo sapiens_hsa049711.58988457
36Gap junction_Homo sapiens_hsa045401.55705322
37Calcium signaling pathway_Homo sapiens_hsa040201.55254284
38Long-term depression_Homo sapiens_hsa047301.50249382
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.49515208
40Renin secretion_Homo sapiens_hsa049241.47542609
41Huntingtons disease_Homo sapiens_hsa050161.45842985
42Ether lipid metabolism_Homo sapiens_hsa005651.45406112
43Serotonergic synapse_Homo sapiens_hsa047261.43939969
44Protein export_Homo sapiens_hsa030601.39441687
45cAMP signaling pathway_Homo sapiens_hsa040241.39096170
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36898923
47Ribosome_Homo sapiens_hsa030101.34201097
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33976085
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.32827155
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32638107
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31979528
52Melanogenesis_Homo sapiens_hsa049161.30779632
53Fanconi anemia pathway_Homo sapiens_hsa034601.30298836
54Glioma_Homo sapiens_hsa052141.27335444
55Alzheimers disease_Homo sapiens_hsa050101.25288903
56GnRH signaling pathway_Homo sapiens_hsa049121.23429125
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21948417
58SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21696957
59ErbB signaling pathway_Homo sapiens_hsa040121.19659552
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17917197
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17688456
62One carbon pool by folate_Homo sapiens_hsa006701.17461267
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12864653
64Basal transcription factors_Homo sapiens_hsa030221.12477121
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11457233
66ABC transporters_Homo sapiens_hsa020101.08986091
67Estrogen signaling pathway_Homo sapiens_hsa049151.08315224
68Chemical carcinogenesis_Homo sapiens_hsa052041.06545248
69Dilated cardiomyopathy_Homo sapiens_hsa054141.06408589
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04972106
71Type II diabetes mellitus_Homo sapiens_hsa049301.00404185
72Rap1 signaling pathway_Homo sapiens_hsa040151.00018577
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.99207007
74Homologous recombination_Homo sapiens_hsa034400.98253737
75Cardiac muscle contraction_Homo sapiens_hsa042600.97045261
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.95617832
77Choline metabolism in cancer_Homo sapiens_hsa052310.95301933
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95144124
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94575023
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93265541
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91475237
82Peroxisome_Homo sapiens_hsa041460.90438603
83Pyrimidine metabolism_Homo sapiens_hsa002400.87915997
84Wnt signaling pathway_Homo sapiens_hsa043100.85172682
85Endometrial cancer_Homo sapiens_hsa052130.84724147
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83680282
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83166079
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.83101158
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82008770
90Regulation of autophagy_Homo sapiens_hsa041400.81615290
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.80573679
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80334743
93Tryptophan metabolism_Homo sapiens_hsa003800.80093873
94Ras signaling pathway_Homo sapiens_hsa040140.76968186
95Dorso-ventral axis formation_Homo sapiens_hsa043200.76774075
96Phototransduction_Homo sapiens_hsa047440.75613722
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74586748
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74502387
99MAPK signaling pathway_Homo sapiens_hsa040100.72705669
100Basal cell carcinoma_Homo sapiens_hsa052170.72004111
101Caffeine metabolism_Homo sapiens_hsa002320.71707937
102Renal cell carcinoma_Homo sapiens_hsa052110.71593327
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71022283
104Melanoma_Homo sapiens_hsa052180.69312143
105VEGF signaling pathway_Homo sapiens_hsa043700.68478689
106Metabolic pathways_Homo sapiens_hsa011000.68044668
107Arachidonic acid metabolism_Homo sapiens_hsa005900.66894072
108Oocyte meiosis_Homo sapiens_hsa041140.66760529
109Hedgehog signaling pathway_Homo sapiens_hsa043400.66189050
110Collecting duct acid secretion_Homo sapiens_hsa049660.65708693
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65330437
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.65326985
113Purine metabolism_Homo sapiens_hsa002300.64561325
114Prion diseases_Homo sapiens_hsa050200.63379317
115Colorectal cancer_Homo sapiens_hsa052100.61426808
116Hippo signaling pathway_Homo sapiens_hsa043900.61220989
117Circadian rhythm_Homo sapiens_hsa047100.58855537
118N-Glycan biosynthesis_Homo sapiens_hsa005100.58794470
119Glutathione metabolism_Homo sapiens_hsa004800.58511760
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58244267
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57003051
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56810710
123Non-small cell lung cancer_Homo sapiens_hsa052230.56606890
124Inositol phosphate metabolism_Homo sapiens_hsa005620.54852326
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52638767
126African trypanosomiasis_Homo sapiens_hsa051430.52232180
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52032711
128Retinol metabolism_Homo sapiens_hsa008300.51624746
129Nitrogen metabolism_Homo sapiens_hsa009100.51242076
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51191073
131Fatty acid biosynthesis_Homo sapiens_hsa000610.50644170
132Tight junction_Homo sapiens_hsa045300.50555417
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49587372
134Lysine degradation_Homo sapiens_hsa003100.47998771
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47302365
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46401534
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46295944
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45914310
139Protein digestion and absorption_Homo sapiens_hsa049740.45602373
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45419979
141Selenocompound metabolism_Homo sapiens_hsa004500.43969680
142Steroid biosynthesis_Homo sapiens_hsa001000.43728310
143p53 signaling pathway_Homo sapiens_hsa041150.42961133
144Alcoholism_Homo sapiens_hsa050340.40971639
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40014942
146Pancreatic secretion_Homo sapiens_hsa049720.38349067
147Ovarian steroidogenesis_Homo sapiens_hsa049130.37194676
148Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36788895
149Glycerolipid metabolism_Homo sapiens_hsa005610.36664847
150Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35984746
151AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35957394
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35224472
153Thyroid hormone synthesis_Homo sapiens_hsa049180.34626005
154Notch signaling pathway_Homo sapiens_hsa043300.34202519
155RNA degradation_Homo sapiens_hsa030180.34198825
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31452860

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