TMEM45B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)6.10283789
2low-density lipoprotein particle clearance (GO:0034383)5.85177807
3carnitine shuttle (GO:0006853)5.34023862
4epoxygenase P450 pathway (GO:0019373)5.32934924
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.31556024
6fatty acid transmembrane transport (GO:1902001)5.21724366
7NADH metabolic process (GO:0006734)5.13150949
8bundle of His cell to Purkinje myocyte communication (GO:0086069)5.10682606
9cellular glucuronidation (GO:0052695)5.09031596
10fatty acid beta-oxidation (GO:0006635)5.02112514
11uronic acid metabolic process (GO:0006063)4.91802783
12glucuronate metabolic process (GO:0019585)4.91802783
13triglyceride biosynthetic process (GO:0019432)4.91311885
14brown fat cell differentiation (GO:0050873)4.90025958
15biotin metabolic process (GO:0006768)4.87994993
16regulation of bile acid biosynthetic process (GO:0070857)4.83836628
17very-low-density lipoprotein particle assembly (GO:0034379)4.77537169
18neutral lipid biosynthetic process (GO:0046460)4.72959359
19acylglycerol biosynthetic process (GO:0046463)4.72959359
20intestinal absorption (GO:0050892)4.67895999
21white fat cell differentiation (GO:0050872)4.61044194
22long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.52589153
23regulation of guanylate cyclase activity (GO:0031282)4.50285591
24carnitine transmembrane transport (GO:1902603)4.38193407
25tricarboxylic acid cycle (GO:0006099)4.37022536
26fatty-acyl-CoA metabolic process (GO:0035337)4.36678336
27bile acid and bile salt transport (GO:0015721)4.34515018
28triglyceride catabolic process (GO:0019433)4.33892866
29fatty acid catabolic process (GO:0009062)4.33838915
30acyl-CoA biosynthetic process (GO:0071616)4.29896033
31thioester biosynthetic process (GO:0035384)4.29896033
32vitamin transmembrane transport (GO:0035461)4.28336748
33fatty acid oxidation (GO:0019395)4.23503626
34fatty-acyl-CoA biosynthetic process (GO:0046949)4.22739851
35ethanol oxidation (GO:0006069)4.21077870
36long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.20708238
37lipid oxidation (GO:0034440)4.20077405
38carnitine transport (GO:0015879)4.16173426
39amino-acid betaine transport (GO:0015838)4.16173426
40positive regulation of fatty acid oxidation (GO:0046321)4.11386257
41drug metabolic process (GO:0017144)4.07890517
42regulation of triglyceride catabolic process (GO:0010896)4.05609519
43exogenous drug catabolic process (GO:0042738)4.03554196
44glycerol metabolic process (GO:0006071)4.03423174
45negative regulation of protein autophosphorylation (GO:0031953)4.00225800
46regulation of fatty acid oxidation (GO:0046320)3.97559971
47plasma lipoprotein particle assembly (GO:0034377)3.97502711
48lipid storage (GO:0019915)3.97426530
49drug catabolic process (GO:0042737)3.91168856
50valine metabolic process (GO:0006573)3.89221467
51ethanol metabolic process (GO:0006067)3.89071090
52lipid particle organization (GO:0034389)3.87322365
53fat-soluble vitamin biosynthetic process (GO:0042362)3.85736278
54positive regulation of fatty acid beta-oxidation (GO:0032000)3.82285717
55neutral lipid catabolic process (GO:0046461)3.79177964
56acylglycerol catabolic process (GO:0046464)3.79177964
57negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.75110017
58sulfate transmembrane transport (GO:1902358)3.73664072
59positive regulation of lipid catabolic process (GO:0050996)3.72464176
60high-density lipoprotein particle remodeling (GO:0034375)3.71266731
61regulation of cholesterol storage (GO:0010885)3.71096362
62transcytosis (GO:0045056)3.70404303
63regulation of cholesterol esterification (GO:0010872)3.66919939
64low-density lipoprotein particle remodeling (GO:0034374)3.61205235
65proline transport (GO:0015824)3.59821530
66regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.59339018
67endocrine process (GO:0050886)3.59339018
68regulation of systemic arterial blood pressure by hormone (GO:0001990)3.59339018
69bile acid metabolic process (GO:0008206)3.57373888
70plasma lipoprotein particle remodeling (GO:0034369)3.57285439
71protein-lipid complex remodeling (GO:0034368)3.57285439
72macromolecular complex remodeling (GO:0034367)3.57285439
73angiotensin maturation (GO:0002003)3.56598658
74alditol metabolic process (GO:0019400)3.56568600
75regulation of cholesterol homeostasis (GO:2000188)3.56557275
76arginine metabolic process (GO:0006525)3.54736900
77drug transmembrane transport (GO:0006855)3.54344527
78diacylglycerol metabolic process (GO:0046339)3.53988420
79primary alcohol catabolic process (GO:0034310)3.51035328
80hemidesmosome assembly (GO:0031581)3.49616509
81lipoprotein transport (GO:0042953)3.49266289
82CDP-diacylglycerol biosynthetic process (GO:0016024)3.47928043
83purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.46052177
843-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.46052177
85positive regulation of guanylate cyclase activity (GO:0031284)3.46034990
86phospholipid efflux (GO:0033700)3.44587928
87reverse cholesterol transport (GO:0043691)3.43864157
88CDP-diacylglycerol metabolic process (GO:0046341)3.42296047
89protein-lipid complex assembly (GO:0065005)3.41252271
90phenylpropanoid metabolic process (GO:0009698)3.40533788
91intracellular lipid transport (GO:0032365)3.39729948
92desmosome organization (GO:0002934)3.38966439
93cholesterol efflux (GO:0033344)3.38853565
94calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.37897052
95adenosine metabolic process (GO:0046085)3.34883473
96UDP-N-acetylglucosamine metabolic process (GO:0006047)3.33778807
97plasma lipoprotein particle organization (GO:0071827)3.32593654
98alanine transport (GO:0032328)3.32460213
99triglyceride metabolic process (GO:0006641)3.31015096
100drug transport (GO:0015893)3.30302156
101acetyl-CoA metabolic process (GO:0006084)3.27799061
102coenzyme A biosynthetic process (GO:0015937)3.27617295
103long-chain fatty acid transport (GO:0015909)3.26256143
104positive regulation of fatty acid metabolic process (GO:0045923)3.24632887
105sphingomyelin metabolic process (GO:0006684)3.22762556
106hormone catabolic process (GO:0042447)3.21910571
107monocarboxylic acid catabolic process (GO:0072329)3.20164771
108regulation of protein activation cascade (GO:2000257)3.19557717
109intestinal cholesterol absorption (GO:0030299)3.18312725
110peptide hormone processing (GO:0016486)3.17792638
111lipoprotein metabolic process (GO:0042157)3.17305176
112regulation of systemic arterial blood pressure (GO:0003073)3.16008284
113primary alcohol metabolic process (GO:0034308)3.15770223
114regulation of complement activation (GO:0030449)3.14828284
115acylglycerol metabolic process (GO:0006639)3.13994847
116acyl-CoA metabolic process (GO:0006637)3.13264306
117thioester metabolic process (GO:0035383)3.13264306
118actin filament depolymerization (GO:0030042)3.12537891
119fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11881446
120O-glycan processing (GO:0016266)3.10705695
121regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.10539570
122neutral lipid metabolic process (GO:0006638)3.08516187
123cholesterol homeostasis (GO:0042632)3.08400024
124quaternary ammonium group transport (GO:0015697)3.07959596
125cGMP-mediated signaling (GO:0019934)3.07554824
126urea metabolic process (GO:0019627)3.07358857
127digestion (GO:0007586)3.05872463
128protein-lipid complex subunit organization (GO:0071825)3.05845478
129vitamin transport (GO:0051180)3.05795691
130NADPH regeneration (GO:0006740)3.04892009
131urea cycle (GO:0000050)3.04475570
132heme transport (GO:0015886)3.03963831
133sulfate transport (GO:0008272)3.03327630
134sterol homeostasis (GO:0055092)3.02837431
135maintenance of gastrointestinal epithelium (GO:0030277)3.02484517
136branched-chain amino acid catabolic process (GO:0009083)3.02362629
137transepithelial transport (GO:0070633)3.01912323
138succinate metabolic process (GO:0006105)3.00274218
139negative regulation of protein activation cascade (GO:2000258)2.99581757
140L-ascorbic acid metabolic process (GO:0019852)2.99329368
141L-serine transport (GO:0015825)2.95466612
142pentose-phosphate shunt (GO:0006098)2.94514204
143protein carboxylation (GO:0018214)2.93729303
144peptidyl-glutamic acid carboxylation (GO:0017187)2.93729303
145glutamine family amino acid biosynthetic process (GO:0009084)2.92481075
146branched-chain amino acid metabolic process (GO:0009081)2.92341360
147tricarboxylic acid metabolic process (GO:0072350)2.91948620
148glycerolipid catabolic process (GO:0046503)2.91357981
149urate metabolic process (GO:0046415)2.90600999
150intestinal epithelial cell development (GO:0060576)2.90495476
151response to dietary excess (GO:0002021)2.89462629
152retinol metabolic process (GO:0042572)2.88582726
153positive regulation of triglyceride metabolic process (GO:0090208)2.88566629
154alkaloid metabolic process (GO:0009820)2.88161747
155glycine transport (GO:0015816)2.88133915
156flavonoid metabolic process (GO:0009812)2.88014584
157regulation of fatty acid beta-oxidation (GO:0031998)2.87838491
158digestive system process (GO:0022600)2.87600518
159regulation of cholesterol metabolic process (GO:0090181)2.87078060
160fructose metabolic process (GO:0006000)2.86146989
161negative regulation of complement activation (GO:0045916)2.85240282
162fatty acid transport (GO:0015908)2.85087282
163cellular response to lithium ion (GO:0071285)2.84777797
164positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.84376769
165negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.83023878
166auditory receptor cell differentiation (GO:0042491)2.82553677
167erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82295703
168L-phenylalanine metabolic process (GO:0006558)2.82295703
169sulfur compound transport (GO:0072348)2.82039262
170sodium ion homeostasis (GO:0055078)2.80797057
171alpha-linolenic acid metabolic process (GO:0036109)2.79977789
172amino acid transmembrane transport (GO:0003333)2.77870182
173erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.77823965
174L-phenylalanine catabolic process (GO:0006559)2.77823965
175positive regulation of lipid storage (GO:0010884)2.77698180
176phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.76241368
177complement activation, classical pathway (GO:0006958)2.73573533
178nitrogen cycle metabolic process (GO:0071941)2.73176733
179carnitine metabolic process (GO:0009437)2.72933951
180regulation of acyl-CoA biosynthetic process (GO:0050812)2.72876174
181short-chain fatty acid metabolic process (GO:0046459)2.71982966
182cellular lipid catabolic process (GO:0044242)2.64791203
183regulation of cholesterol transport (GO:0032374)2.64268776
184regulation of sterol transport (GO:0032371)2.64268776
185regulation of triglyceride metabolic process (GO:0090207)2.62966568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.78966346
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.18271708
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.08974788
4EGR1_23403033_ChIP-Seq_LIVER_Mouse2.87856031
5CLOCK_20551151_ChIP-Seq_293T_Human2.66090341
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44620862
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.41126756
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.36755858
9ZNF263_19887448_ChIP-Seq_K562_Human2.32166330
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29341613
11* SOX2_20726797_ChIP-Seq_SW620_Human2.26292807
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.22017436
13PPAR_26484153_Chip-Seq_NCI-H1993_Human2.12976032
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.12122678
15* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11786970
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.06141227
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02805162
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.00345569
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse10.3692154
20* GATA4_25053715_ChIP-Seq_YYC3_Human1.99372468
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90132797
22* FOXA1_25552417_ChIP-Seq_VCAP_Human1.78793966
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76103379
24* ESR1_20079471_ChIP-ChIP_T-47D_Human1.71612734
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66588625
26PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.66456265
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.61420350
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58632523
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55155469
30* GATA6_25053715_ChIP-Seq_YYC3_Human1.53746972
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.53323002
32GATA1_22025678_ChIP-Seq_K562_Human1.50552505
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.49331297
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.48020780
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.44151849
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43952662
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43234884
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39192498
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38667944
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36923568
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28476112
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27259474
43VDR_22108803_ChIP-Seq_LS180_Human1.26488808
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25798823
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.23493122
46* FOXO3_23340844_ChIP-Seq_DLD1_Human1.19946748
47KLF5_25053715_ChIP-Seq_YYC3_Human1.18907042
48PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17369677
49CJUN_26792858_Chip-Seq_BT549_Human1.16617213
50* CEBPB_22108803_ChIP-Seq_LS180_Human1.15881206
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15309361
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14692021
53* BCAT_22108803_ChIP-Seq_LS180_Human1.14628098
54RXR_22108803_ChIP-Seq_LS180_Human1.14502866
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14442784
56GATA3_24758297_ChIP-Seq_MCF-7_Human1.13495544
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.12235767
58* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.10610894
59EGR1_19032775_ChIP-ChIP_M12_Human1.10585888
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10575038
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10346751
62RACK7_27058665_Chip-Seq_MCF-7_Human1.09849387
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09445174
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07799099
65AR_20517297_ChIP-Seq_VCAP_Human1.06761330
66GATA2_19941826_ChIP-Seq_K562_Human1.05389836
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05195456
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04981315
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.04096107
70* TP63_23658742_ChIP-Seq_EP156T_Human1.03362004
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03357631
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02619981
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99578615
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99482162
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99144675
76* FOXA1_25329375_ChIP-Seq_VCAP_Human0.98589382
77* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98589382
78CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98559549
79EP300_21415370_ChIP-Seq_HL-1_Mouse0.98015898
80NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97671462
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97140199
82ZNF274_21170338_ChIP-Seq_K562_Hela0.95650215
83* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95292511
84* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95292511
85* ARNT_22903824_ChIP-Seq_MCF-7_Human0.95063024
86PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95050853
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94852506
88ATF3_27146783_Chip-Seq_COLON_Human0.93771398
89* TCF4_22108803_ChIP-Seq_LS180_Human0.93564217
90* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93159075
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92620117
92NANOG_20526341_ChIP-Seq_ESCs_Human0.91623973
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91379863
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91323432
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90065261
96* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89254020
97* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88853195
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88502423
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84999652
100NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84518868
101PIAS1_25552417_ChIP-Seq_VCAP_Human0.84512942
102* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84453745
103EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83965364
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83382963
105NCOR_22424771_ChIP-Seq_293T_Human0.82891380
106VDR_24787735_ChIP-Seq_THP-1_Human0.81432842
107* AHR_22903824_ChIP-Seq_MCF-7_Human0.80765566
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79812814
109ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79737050
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79654918
111TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79608799
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.79568887
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79214612
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79070486
115* FOXH1_21741376_ChIP-Seq_ESCs_Human0.79024668
116GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78928762
117FLI1_27457419_Chip-Seq_LIVER_Mouse0.78811560
118* HNF4A_19822575_ChIP-Seq_HepG2_Human0.78804010
119P53_21459846_ChIP-Seq_SAOS-2_Human0.77620265
120CDX2_22108803_ChIP-Seq_LS180_Human0.76802081
121DROSHA_22980978_ChIP-Seq_HELA_Human0.76551863
122GATA3_21878914_ChIP-Seq_MCF-7_Human0.76502342
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76133313
124MYC_19829295_ChIP-Seq_ESCs_Human0.76088384
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75647384
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74927035
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74596645
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74155057
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73202034
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73130761
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72920162
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72920162
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72782535
134ER_23166858_ChIP-Seq_MCF-7_Human0.72246093
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71638442
136OCT4_20526341_ChIP-Seq_ESCs_Human0.71537301
137* FOXA2_19822575_ChIP-Seq_HepG2_Human0.70856781
138P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70032905
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69421752

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.01086569
2MP0005666_abnormal_adipose_tissue4.23933859
3MP0004185_abnormal_adipocyte_glucose3.62097306
4MP0004130_abnormal_muscle_cell3.40174719
5MP0005360_urolithiasis3.38058584
6MP0010234_abnormal_vibrissa_follicle3.36321526
7MP0002876_abnormal_thyroid_physiology3.10900229
8MP0005375_adipose_tissue_phenotype2.81585515
9MP0010329_abnormal_lipoprotein_level2.80344278
10MP0002971_abnormal_brown_adipose2.67722400
11MP0003195_calcinosis2.61744614
12MP0001666_abnormal_nutrient_absorption2.50574047
13MP0002736_abnormal_nociception_after2.43361101
14MP0002735_abnormal_chemical_nociception2.32525613
15MP0009115_abnormal_fat_cell2.22340394
16MP0001968_abnormal_touch/_nociception2.21630610
17MP0003866_abnormal_defecation2.15938305
18MP0000013_abnormal_adipose_tissue2.12749336
19MP0002837_dystrophic_cardiac_calcinosis2.12338367
20MP0003868_abnormal_feces_composition2.06150614
21MP0003191_abnormal_cellular_cholesterol2.03779134
22MP0001986_abnormal_taste_sensitivity2.02659104
23MP0004264_abnormal_extraembryonic_tissu1.94135084
24MP0005636_abnormal_mineral_homeostasis1.92820965
25MP0005334_abnormal_fat_pad1.87918531
26MP0002118_abnormal_lipid_homeostasis1.85005862
27MP0000003_abnormal_adipose_tissue1.77049086
28MP0002796_impaired_skin_barrier1.74179236
29MP0005448_abnormal_energy_balance1.71535762
30MP0000566_synostosis1.69200242
31MP0005535_abnormal_body_temperature1.67227767
32MP0002970_abnormal_white_adipose1.64009880
33MP0004147_increased_porphyrin_level1.58498695
34MP0000462_abnormal_digestive_system1.56221184
35MP0002733_abnormal_thermal_nociception1.55327926
36MP0004782_abnormal_surfactant_physiolog1.53158761
37MP0002138_abnormal_hepatobiliary_system1.53096457
38MP0005275_abnormal_skin_tensile1.52009620
39MP0005365_abnormal_bile_salt1.50373379
40MP0001664_abnormal_digestion1.48293760
41MP0003183_abnormal_peptide_metabolism1.47531181
42MP0001663_abnormal_digestive_system1.47471071
43MP0008438_abnormal_cutaneous_collagen1.42268492
44MP0003705_abnormal_hypodermis_morpholog1.38478788
45MP0005409_darkened_coat_color1.34803168
46MP0002139_abnormal_hepatobiliary_system1.34075099
47MP0001756_abnormal_urination1.32496884
48MP0003879_abnormal_hair_cell1.31765348
49MP0009643_abnormal_urine_homeostasis1.31076516
50MP0003724_increased_susceptibility_to1.30865157
51MP0006036_abnormal_mitochondrial_physio1.30685755
52MP0010678_abnormal_skin_adnexa1.30479276
53MP0005381_digestive/alimentary_phenotyp1.28688195
54MP0004858_abnormal_nervous_system1.26036598
55MP0000538_abnormal_urinary_bladder1.25974233
56MP0000609_abnormal_liver_physiology1.25948931
57MP0005085_abnormal_gallbladder_physiolo1.25456792
58MP0002734_abnormal_mechanical_nocicepti1.23516541
59MP0009840_abnormal_foam_cell1.23357469
60MP0005332_abnormal_amino_acid1.22328848
61MP0002098_abnormal_vibrissa_morphology1.18760425
62MP0003045_fibrosis1.17152700
63MP0005584_abnormal_enzyme/coenzyme_acti1.14266561
64MP0008872_abnormal_physiological_respon1.11761759
65MP0010155_abnormal_intestine_physiology1.10763243
66MP0002254_reproductive_system_inflammat1.10715554
67MP0001970_abnormal_pain_threshold1.10423854
68MP0008004_abnormal_stomach_pH1.08571952
69MP0010352_gastrointestinal_tract_polyps1.08339474
70MP0000537_abnormal_urethra_morphology1.08058733
71MP0001661_extended_life_span1.07659751
72MP0004019_abnormal_vitamin_homeostasis1.07176234
73MP0002166_altered_tumor_susceptibility1.06964607
74MP0003300_gastrointestinal_ulcer1.06754917
75MP0001873_stomach_inflammation1.05146856
76MP0004270_analgesia1.05038314
77MP0003959_abnormal_lean_body1.03819944
78MP0005167_abnormal_blood-brain_barrier1.02491073
79MP0009379_abnormal_foot_pigmentation1.02042936
80MP0002909_abnormal_adrenal_gland1.01427148
81MP0002078_abnormal_glucose_homeostasis1.01392781
82MP0000477_abnormal_intestine_morphology0.96321236
83MP0005083_abnormal_biliary_tract0.94913055
84MP0002060_abnormal_skin_morphology0.94657654
85MP0010771_integument_phenotype0.93701589
86MP0005452_abnormal_adipose_tissue0.92096424
87MP0003011_delayed_dark_adaptation0.91900941
88MP0000427_abnormal_hair_cycle0.91800089
89MP0003186_abnormal_redox_activity0.90308935
90MP0000230_abnormal_systemic_arterial0.88503415
91MP0004043_abnormal_pH_regulation0.88211044
92MP0005319_abnormal_enzyme/_coenzyme0.87977478
93MP0005408_hypopigmentation0.83660262
94MP0002006_tumorigenesis0.82734097
95MP0009642_abnormal_blood_homeostasis0.82078337
96MP0001501_abnormal_sleep_pattern0.80906590
97MP0001881_abnormal_mammary_gland0.80494463
98MP0005501_abnormal_skin_physiology0.80242238
99MP0002136_abnormal_kidney_physiology0.80000562
100MP0001764_abnormal_homeostasis0.79056954
101MP0003252_abnormal_bile_duct0.78857689
102MP0001765_abnormal_ion_homeostasis0.78452701
103MP0003806_abnormal_nucleotide_metabolis0.76656878
104MP0004272_abnormal_basement_membrane0.76612485
105MP0002132_abnormal_respiratory_system0.75942537
106MP0005166_decreased_susceptibility_to0.75825252
107MP0001485_abnormal_pinna_reflex0.75728960
108MP0008875_abnormal_xenobiotic_pharmacok0.75004407
109MP0008961_abnormal_basal_metabolism0.74997409
110MP0002009_preneoplasia0.74507907
111MP0004484_altered_response_of0.74257506
112MP0003878_abnormal_ear_physiology0.73958224
113MP0005377_hearing/vestibular/ear_phenot0.73958224
114MP0006276_abnormal_autonomic_nervous0.73128144
115MP0003953_abnormal_hormone_level0.73051199
116MP0000678_abnormal_parathyroid_gland0.71944374
117MP0009697_abnormal_copulation0.71434966
118MP0009780_abnormal_chondrocyte_physiolo0.68918369
119MP0003718_maternal_effect0.68289125
120MP0000383_abnormal_hair_follicle0.68040712
121MP0010386_abnormal_urinary_bladder0.67640393
122MP0002277_abnormal_respiratory_mucosa0.65958816
123MP0003122_maternal_imprinting0.63846679
124MP0008469_abnormal_protein_level0.62701530
125MP0001216_abnormal_epidermal_layer0.61672856
126MP0003638_abnormal_response/metabolism_0.61027410
127MP0005058_abnormal_lysosome_morphology0.60008133
128MP0000490_abnormal_crypts_of0.57517224
129MP0005367_renal/urinary_system_phenotyp0.56545065
130MP0000516_abnormal_urinary_system0.56545065
131MP0005310_abnormal_salivary_gland0.55880397
132MP0002693_abnormal_pancreas_physiology0.55164351
133MP0001944_abnormal_pancreas_morphology0.54680558
134MP0000604_amyloidosis0.54140073
135MP0005395_other_phenotype0.51893923
136MP0001845_abnormal_inflammatory_respons0.51666638
137MP0005379_endocrine/exocrine_gland_phen0.51172032
138MP0003329_amyloid_beta_deposits0.50707121
139MP0000467_abnormal_esophagus_morphology0.48422138
140MP0005645_abnormal_hypothalamus_physiol0.48061628
141MP0005220_abnormal_exocrine_pancreas0.47223715

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)5.52923114
2Hyperglycinuria (HP:0003108)5.47698634
3Hypobetalipoproteinemia (HP:0003563)5.11505817
4Ileus (HP:0002595)5.04809072
5Abnormality of proline metabolism (HP:0010907)5.01270049
6Hydroxyprolinuria (HP:0003080)5.01270049
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.40236628
8Acanthosis nigricans (HP:0000956)4.23798625
9Right ventricular cardiomyopathy (HP:0011663)4.23325261
10Fat malabsorption (HP:0002630)4.19924092
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16908387
12Decreased circulating renin level (HP:0003351)4.15164290
13Abnormality of glycine metabolism (HP:0010895)4.07288502
14Abnormality of serine family amino acid metabolism (HP:0010894)4.07288502
15Myoglobinuria (HP:0002913)4.05581133
16Deep venous thrombosis (HP:0002625)4.01293491
17Abnormality of fatty-acid metabolism (HP:0004359)3.96648918
18Acanthocytosis (HP:0001927)3.87388339
19Xanthomatosis (HP:0000991)3.83921950
20Autoimmune thrombocytopenia (HP:0001973)3.79619397
21Dicarboxylic aciduria (HP:0003215)3.63460944
22Abnormality of dicarboxylic acid metabolism (HP:0010995)3.63460944
23Hypertriglyceridemia (HP:0002155)3.61846489
24Increased muscle lipid content (HP:0009058)3.61418541
25Abnormality of renin-angiotensin system (HP:0000847)3.54192041
26Rhabdomyolysis (HP:0003201)3.52300354
27Prolonged partial thromboplastin time (HP:0003645)3.50139151
28Hypoglycemic coma (HP:0001325)3.47673694
29Palpitations (HP:0001962)3.41464939
30Vascular calcification (HP:0004934)3.38405512
31Abnormality of vitamin metabolism (HP:0100508)3.27814822
32Hepatic necrosis (HP:0002605)3.26811151
33Alkalosis (HP:0001948)3.24689609
34Nausea (HP:0002018)3.22674157
35Bone cyst (HP:0012062)3.22646847
36Intrahepatic cholestasis (HP:0001406)3.17378291
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17346571
38Systemic lupus erythematosus (HP:0002725)3.08170862
39Pigmentary retinal degeneration (HP:0001146)3.04680688
40Widely patent fontanelles and sutures (HP:0004492)3.01863551
41Hyperammonemia (HP:0001987)3.01836969
42Insulin-resistant diabetes mellitus (HP:0000831)3.01669098
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98761357
44Pheochromocytoma (HP:0002666)2.93280388
45Glomerulonephritis (HP:0000099)2.92225362
46Epidermoid cyst (HP:0200040)2.90779409
47Malnutrition (HP:0004395)2.87786157
48Complement deficiency (HP:0004431)2.86193026
49Facial diplegia (HP:0001349)2.85554732
50Chronic diarrhea (HP:0002028)2.83647444
51Long foot (HP:0001833)2.79833673
52Growth hormone excess (HP:0000845)2.79280476
53Cardiovascular calcification (HP:0011915)2.78318968
54Ketoacidosis (HP:0001993)2.72023873
55Goiter (HP:0000853)2.71627498
56Conjunctival hamartoma (HP:0100780)2.69541192
57Hypolipoproteinemia (HP:0010981)2.67552017
58Steatorrhea (HP:0002570)2.65100013
59Generalized aminoaciduria (HP:0002909)2.65003751
60Congenital sensorineural hearing impairment (HP:0008527)2.63888087
61Hyperaldosteronism (HP:0000859)2.63751665
62Abnormal tarsal ossification (HP:0008369)2.59899046
63Neuroendocrine neoplasm (HP:0100634)2.53908292
64Abnormal respiratory epithelium morphology (HP:0012253)2.53466289
65Abnormal respiratory motile cilium morphology (HP:0005938)2.53466289
66Joint hemorrhage (HP:0005261)2.51640275
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.50296912
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.50133873
69Absent/shortened dynein arms (HP:0200106)2.50133873
70Pancreatitis (HP:0001733)2.48967151
71Muscle stiffness (HP:0003552)2.48558936
72Hyperactive renin-angiotensin system (HP:0000841)2.48437276
73Proximal tubulopathy (HP:0000114)2.47155185
74Insulin resistance (HP:0000855)2.43266255
75Potter facies (HP:0002009)2.39123510
76Facial shape deformation (HP:0011334)2.39123510
77Chronic bronchitis (HP:0004469)2.38843674
78Mesangial abnormality (HP:0001966)2.38795615
79Abdominal distention (HP:0003270)2.37920511
80Abnormal ciliary motility (HP:0012262)2.31735706
81Hepatocellular necrosis (HP:0001404)2.30975349
82Confusion (HP:0001289)2.26793890
83Vacuolated lymphocytes (HP:0001922)2.25307822
84Gastrointestinal dysmotility (HP:0002579)2.24887280
85Hypophosphatemic rickets (HP:0004912)2.24877352
86Abnormal respiratory motile cilium physiology (HP:0012261)2.23582799
87Hypercortisolism (HP:0001578)2.22881352
88Increased connective tissue (HP:0009025)2.22645305
89Rickets (HP:0002748)2.22138057
90Hypotension (HP:0002615)2.20860355
91Ketosis (HP:0001946)2.20569850
92Difficulty running (HP:0009046)2.20061539
93Abnormal cartilage morphology (HP:0002763)2.18109004
94Abnormality of the vocal cords (HP:0008777)2.17822118
95Abnormal hemoglobin (HP:0011902)2.17699128
96Dehydration (HP:0001944)2.16838963
97Onycholysis (HP:0001806)2.15935493
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.14637047
99Lethargy (HP:0001254)2.14523990
100Abnormality of urine glucose concentration (HP:0011016)2.13126858
101Glycosuria (HP:0003076)2.13126858
102Abnormality of complement system (HP:0005339)2.13087165
103Villous atrophy (HP:0011473)2.12373150
104Abnormality of small intestinal villus morphology (HP:0011472)2.12373150
105Metabolic alkalosis (HP:0200114)2.11015255
106Acute encephalopathy (HP:0006846)2.09372070
107Flat acetabular roof (HP:0003180)2.09011741
108Nephritis (HP:0000123)2.08119337
109Abnormality of the common coagulation pathway (HP:0010990)2.07349983
110Focal segmental glomerulosclerosis (HP:0000097)2.07139150
111Hemorrhage of the eye (HP:0011885)2.06645199
112Gout (HP:0001997)2.06403728
113Abnormality of the vitamin B12 metabolism (HP:0004341)2.06008819
114Cerebral hemorrhage (HP:0001342)2.04811161
115Rhinitis (HP:0012384)2.04558106
116Hypokalemia (HP:0002900)2.03398593
117Ventricular fibrillation (HP:0001663)2.03342779
118Hyperkalemia (HP:0002153)2.03321007
119Increased serum pyruvate (HP:0003542)2.02813542
120Abnormality of glycolysis (HP:0004366)2.02813542
121Insidious onset (HP:0003587)2.02681679
122Termporal pattern (HP:0011008)2.02681679
123Hyperphosphaturia (HP:0003109)2.01438892
124Bronchiectasis (HP:0002110)2.00411862
125Atrophic scars (HP:0001075)1.99734370
126Vomiting (HP:0002013)1.98762128
127Abnormality of carpal bone ossification (HP:0006257)1.98717991
128Tetraparesis (HP:0002273)1.98640725
129Hypoalphalipoproteinemia (HP:0003233)1.98586363
130Increased intramyocellular lipid droplets (HP:0012240)1.98079925
131Autoimmune hemolytic anemia (HP:0001890)1.96858510
132Abnormal glucose tolerance (HP:0001952)1.95903106
133Abnormal urine phosphate concentration (HP:0012599)1.95597011
134Abnormality of potassium homeostasis (HP:0011042)1.94830494
135Bradycardia (HP:0001662)1.94609669
136Methylmalonic aciduria (HP:0012120)1.94571993
137Multiple enchondromatosis (HP:0005701)1.92815911
138Palmoplantar hyperkeratosis (HP:0000972)1.91295203
139Glomerulosclerosis (HP:0000096)1.89908371
140Abnormality of purine metabolism (HP:0004352)1.89835980
141Lactic acidosis (HP:0003128)1.88979773
142Conjugated hyperbilirubinemia (HP:0002908)1.88610921
143Abnormality of chloride homeostasis (HP:0011422)1.88456563
144Hyperglycinemia (HP:0002154)1.88328043
145Abnormal biliary tract morphology (HP:0012440)1.88324932
146Abnormal mitochondria in muscle tissue (HP:0008316)1.88292443
147Metabolic acidosis (HP:0001942)1.87493141
148Protuberant abdomen (HP:0001538)1.86948774
149Pili torti (HP:0003777)1.86077948
150Hyperparathyroidism (HP:0000843)1.85849901
151Hyperlipoproteinemia (HP:0010980)1.84992644
152Hypophosphatemia (HP:0002148)1.84811697
153Mucopolysacchariduria (HP:0008155)1.84309156
154Urinary glycosaminoglycan excretion (HP:0003541)1.84309156
155Cupped ribs (HP:0000887)1.83780821
156Abnormality of vitamin B metabolism (HP:0004340)1.83724453
157Abnormal hair laboratory examination (HP:0003328)1.81521394
158Hyponatremia (HP:0002902)1.80676527
159Abnormality of magnesium homeostasis (HP:0004921)1.79950915
160Rectal prolapse (HP:0002035)1.78637135
161Curly hair (HP:0002212)1.78507741
162Hypothermia (HP:0002045)1.77111231
163Hyperuricemia (HP:0002149)1.77096360
164Increased purine levels (HP:0004368)1.77096360
165Hypercholesterolemia (HP:0003124)1.76932565
166Myotonia (HP:0002486)1.76218073
167Cerebral edema (HP:0002181)1.75792063
168Subcapsular cataract (HP:0000523)1.75659602
169Reduced subcutaneous adipose tissue (HP:0003758)1.75519306
170Abnormality of pain sensation (HP:0010832)1.75148715
171Impaired pain sensation (HP:0007328)1.75148715
172Athetosis (HP:0002305)1.74400297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.97389927
2LMTK24.96964737
3FRK4.70179948
4MST1R4.63054454
5CAMK1D3.21360033
6STK393.17135669
7PDK42.99161688
8PDK32.99161688
9TRIB32.62669708
10BCKDK2.59352476
11MST42.51198040
12RIPK12.37331081
13MAP3K22.30798953
14PRKG22.25492412
15PDK22.02131544
16KSR21.99846091
17OXSR11.98662756
18MYLK1.96898146
19MAP2K11.91312658
20MAP2K21.84222947
21EPHB21.80133129
22CAMK1G1.77690567
23STK241.72244168
24MAPK151.66728366
25FER1.62950256
26RIPK41.58331964
27MET1.56736817
28PIK3CA1.55788586
29GRK51.51351060
30GRK11.50020680
31PRKAA21.44670301
32NME11.42303546
33TESK11.35903244
34CASK1.35672084
35NLK1.31456647
36ADRBK21.23353009
37SIK11.21300006
38ARAF1.18751167
39EPHA21.11338866
40MAP2K61.09582858
41FGFR31.06986124
42EPHA31.05882710
43MAP3K91.01411677
44ERN11.00856674
45LIMK11.00376375
46MAP3K120.99818307
47PDPK10.93542855
48RET0.91548530
49MATK0.91028134
50PTK60.88216281
51CDK90.85272445
52MAPKAPK30.84538305
53IRAK30.81086329
54PRKAA10.80895050
55TAOK10.80712073
56NEK90.79897430
57EPHB10.79760125
58YES10.75561631
59MAP3K10.75087983
60STK380.74992826
61PDK10.74635853
62IRAK10.73758854
63TNIK0.72782076
64WNK30.71804585
65BRSK20.71634591
66CDK60.69429389
67NTRK10.68438594
68FGFR40.67734244
69PRKD30.64265585
70PIM20.62757739
71DDR20.61303188
72INSRR0.60277414
73BCR0.59764614
74PRKCZ0.58509672
75PTK20.58155624
76PRKACG0.56345713
77WNK10.56213580
78TYK20.55694883
79MAPK110.55336928
80BMPR1B0.54494892
81STK30.54337935
82DYRK1B0.53759164
83AKT30.53185322
84JAK10.51586757
85DAPK20.51209438
86RPS6KA20.50152458
87MAP3K30.49808120
88STK38L0.49073295
89PHKG20.44745615
90PHKG10.44745615
91CDC42BPA0.44108147
92EPHA40.43952017
93MAP4K20.43484059
94WNK40.42938869
95PRKCQ0.42573847
96SGK30.42477492
97JAK20.40969689
98PAK30.40922724
99LATS10.40008007
100ERBB30.39801903
101SRC0.39687763
102PDGFRA0.39534161
103TIE10.39363940
104GRK60.36627788
105ERBB20.36272333
106SGK2230.35602581
107SGK4940.35602581
108MARK30.32668501
109FGFR10.32561725
110TNK20.31889595
111LRRK20.31746212
112GSK3A0.31003741
113TRPM70.29869267
114CAMKK20.29102039
115FGFR20.28049516
116PRKCE0.27807258
117ITK0.27448137
118CAMK2D0.27383373
119PRKCI0.26484206
120TLK10.26424933
121IGF1R0.26408683
122CSNK1A10.26214252
123SGK10.26024000
124SGK20.25860991
125PINK10.25403388
126PIK3CG0.25316578
127NEK60.25284447
128ADRBK10.25091352
129RPS6KB10.23764487
130EIF2AK10.23195441
131NUAK10.22987071
132PRKCA0.22306045
133PTK2B0.21495397
134PKN20.20562967
135ILK0.20534948
136TBK10.20440919
137CAMK2G0.19764467
138MAPK40.19628738

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.07965134
2Propanoate metabolism_Homo sapiens_hsa006403.64136887
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.36707020
4PPAR signaling pathway_Homo sapiens_hsa033203.28523437
5Fatty acid metabolism_Homo sapiens_hsa012123.22359371
6Fatty acid degradation_Homo sapiens_hsa000713.11427286
7Fat digestion and absorption_Homo sapiens_hsa049753.10532439
8Fatty acid biosynthesis_Homo sapiens_hsa000612.90772988
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82573022
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.53406212
11Glycerolipid metabolism_Homo sapiens_hsa005612.51083198
12Mineral absorption_Homo sapiens_hsa049782.46914737
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.37599904
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.25814468
15Fatty acid elongation_Homo sapiens_hsa000622.19641236
16Steroid hormone biosynthesis_Homo sapiens_hsa001402.17706606
17Pyruvate metabolism_Homo sapiens_hsa006202.16781590
18Sulfur metabolism_Homo sapiens_hsa009202.16396028
19Renin-angiotensin system_Homo sapiens_hsa046142.09179778
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.96579152
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.83869852
22Carbon metabolism_Homo sapiens_hsa012001.74975025
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.72110750
24Complement and coagulation cascades_Homo sapiens_hsa046101.70213426
25beta-Alanine metabolism_Homo sapiens_hsa004101.64943150
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58068816
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.44006582
28Fructose and mannose metabolism_Homo sapiens_hsa000511.43123911
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42582611
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38573613
31Vitamin digestion and absorption_Homo sapiens_hsa049771.31196574
32Protein digestion and absorption_Homo sapiens_hsa049741.30597384
33Peroxisome_Homo sapiens_hsa041461.29475172
34Arginine and proline metabolism_Homo sapiens_hsa003301.28878393
35Butanoate metabolism_Homo sapiens_hsa006501.25836399
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25604892
37Caffeine metabolism_Homo sapiens_hsa002321.24890882
38Ether lipid metabolism_Homo sapiens_hsa005651.22895746
39Starch and sucrose metabolism_Homo sapiens_hsa005001.17190544
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14186645
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.13771189
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.12212372
43Bile secretion_Homo sapiens_hsa049761.07860734
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07339890
45Tryptophan metabolism_Homo sapiens_hsa003801.06255853
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05112120
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02566146
48Oxidative phosphorylation_Homo sapiens_hsa001900.99687795
49Histidine metabolism_Homo sapiens_hsa003400.96525976
50AMPK signaling pathway_Homo sapiens_hsa041520.96492572
51Galactose metabolism_Homo sapiens_hsa000520.95308034
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94125924
53Pentose phosphate pathway_Homo sapiens_hsa000300.90032786
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88692627
55Thyroid cancer_Homo sapiens_hsa052160.83741814
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81323959
57Parkinsons disease_Homo sapiens_hsa050120.80626509
58Glutathione metabolism_Homo sapiens_hsa004800.78390391
59Thyroid hormone synthesis_Homo sapiens_hsa049180.75577072
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74094887
61Staphylococcus aureus infection_Homo sapiens_hsa051500.73924404
62Insulin signaling pathway_Homo sapiens_hsa049100.71538167
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71284056
64Other glycan degradation_Homo sapiens_hsa005110.70098076
65Alzheimers disease_Homo sapiens_hsa050100.67830811
66Insulin resistance_Homo sapiens_hsa049310.67777792
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67054641
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65108402
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64930646
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59674717
71Sphingolipid metabolism_Homo sapiens_hsa006000.57856047
72ABC transporters_Homo sapiens_hsa020100.55026570
73Pancreatic secretion_Homo sapiens_hsa049720.52792559
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52358669
75Phenylalanine metabolism_Homo sapiens_hsa003600.51429098
76Folate biosynthesis_Homo sapiens_hsa007900.50833991
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50303373
78Salivary secretion_Homo sapiens_hsa049700.49977419
79Arachidonic acid metabolism_Homo sapiens_hsa005900.46513521
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45644557
81Steroid biosynthesis_Homo sapiens_hsa001000.43163229
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42511384
83Metabolic pathways_Homo sapiens_hsa011000.41055471
84Sulfur relay system_Homo sapiens_hsa041220.40978924
85Huntingtons disease_Homo sapiens_hsa050160.40905196
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.39811913
87Renin secretion_Homo sapiens_hsa049240.39629919
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.38031014
89Retinol metabolism_Homo sapiens_hsa008300.36013788
90Glucagon signaling pathway_Homo sapiens_hsa049220.35010128
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34946510
92Linoleic acid metabolism_Homo sapiens_hsa005910.33319438
93Tight junction_Homo sapiens_hsa045300.33033487
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32687598
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30975375
96Salmonella infection_Homo sapiens_hsa051320.30674487
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30673899
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30559160
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30344522
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30237181
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.29507828
102Hepatitis C_Homo sapiens_hsa051600.28698182
103N-Glycan biosynthesis_Homo sapiens_hsa005100.27963923
104Cardiac muscle contraction_Homo sapiens_hsa042600.27163754
105Type II diabetes mellitus_Homo sapiens_hsa049300.27094891
106Tyrosine metabolism_Homo sapiens_hsa003500.26194460
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24400807
108Type I diabetes mellitus_Homo sapiens_hsa049400.24180389
109Gastric acid secretion_Homo sapiens_hsa049710.23665560
110Arginine biosynthesis_Homo sapiens_hsa002200.23425611
111Chemical carcinogenesis_Homo sapiens_hsa052040.23032044
112Ovarian steroidogenesis_Homo sapiens_hsa049130.22459736
113Vitamin B6 metabolism_Homo sapiens_hsa007500.22082670
114Asthma_Homo sapiens_hsa053100.21883071
115Biosynthesis of amino acids_Homo sapiens_hsa012300.21445863
116Insulin secretion_Homo sapiens_hsa049110.19939641
117Vibrio cholerae infection_Homo sapiens_hsa051100.18842607
118HIF-1 signaling pathway_Homo sapiens_hsa040660.18824910
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15503963
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.15086524
121Nitrogen metabolism_Homo sapiens_hsa009100.15014927
122Selenocompound metabolism_Homo sapiens_hsa004500.14362733
123Lysosome_Homo sapiens_hsa041420.14158399
124Amoebiasis_Homo sapiens_hsa051460.14020640
125ECM-receptor interaction_Homo sapiens_hsa045120.13030716
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.12813405
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12057138
128Circadian rhythm_Homo sapiens_hsa047100.06619982
129Collecting duct acid secretion_Homo sapiens_hsa049660.06478808
130Pertussis_Homo sapiens_hsa051330.06182331

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