TMEM50A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; however, its sequence has potential transmembrane domains suggesting that it may be an integral membrane protein. Its position between the RH genes suggests that polymorphisms in this gene may be tightly linked to RH haplotypes and may contribute to selective pressure for or against certain RH haplotypes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)4.40962589
2Arp2/3 complex-mediated actin nucleation (GO:0034314)3.89772281
3respiratory burst (GO:0045730)3.84073050
4axon ensheathment in central nervous system (GO:0032291)3.63216479
5central nervous system myelination (GO:0022010)3.63216479
6signal peptide processing (GO:0006465)3.59360364
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53986150
8protein neddylation (GO:0045116)3.53679207
9regulation of T-helper 1 cell differentiation (GO:0045625)3.51667682
10fatty acid elongation (GO:0030497)3.48076972
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32925768
12mast cell activation (GO:0045576)3.32673318
13positive regulation of macrophage differentiation (GO:0045651)3.29167206
14immunoglobulin mediated immune response (GO:0016064)3.21623392
15actin nucleation (GO:0045010)3.17555259
16phagosome maturation (GO:0090382)3.15444759
17B cell mediated immunity (GO:0019724)3.13441791
18amyloid precursor protein catabolic process (GO:0042987)3.12135505
19negative regulation of interleukin-12 production (GO:0032695)3.11114473
20chaperone-mediated protein transport (GO:0072321)3.05999446
21cytidine metabolic process (GO:0046087)3.04091022
22cytidine catabolic process (GO:0006216)3.04091022
23cytidine deamination (GO:0009972)3.04091022
24thrombin receptor signaling pathway (GO:0070493)3.03461318
25negative regulation of cell killing (GO:0031342)3.01782536
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01782536
27leukocyte aggregation (GO:0070486)3.01713733
28long-chain fatty acid biosynthetic process (GO:0042759)3.00806283
29regulation of T cell tolerance induction (GO:0002664)2.95651797
30sequestering of actin monomers (GO:0042989)2.95561642
31positive regulation of monocyte chemotaxis (GO:0090026)2.95380563
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90429967
33amyloid precursor protein metabolic process (GO:0042982)2.90118005
34regulation of regulatory T cell differentiation (GO:0045589)2.87701285
35T cell migration (GO:0072678)2.87228233
36negative regulation of T-helper cell differentiation (GO:0045623)2.87116505
37negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.87116505
38positive regulation of interleukin-8 secretion (GO:2000484)2.85266284
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83512880
40regulation of T-helper 2 cell differentiation (GO:0045628)2.79791694
41regulation of chronic inflammatory response (GO:0002676)2.79406716
42lymphocyte chemotaxis (GO:0048247)2.78659995
43regulation of platelet aggregation (GO:0090330)2.77617274
44DNA deamination (GO:0045006)2.76422668
45dendritic cell chemotaxis (GO:0002407)2.76392838
46lipoxygenase pathway (GO:0019372)2.75613516
47negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.75542982
48proteasome assembly (GO:0043248)2.75344852
49regulation of B cell receptor signaling pathway (GO:0050855)2.75186351
50cellular response to interferon-beta (GO:0035458)2.74989605
51neutrophil activation (GO:0042119)2.74964298
52eosinophil chemotaxis (GO:0048245)2.74791209
53regulation of tolerance induction (GO:0002643)2.72861795
54regulation of isotype switching to IgG isotypes (GO:0048302)2.69938491
55positive regulation of tolerance induction (GO:0002645)2.69716298
56regulation of platelet activation (GO:0010543)2.69699011
57negative regulation of T cell apoptotic process (GO:0070233)2.66956091
58phagocytosis, engulfment (GO:0006911)2.66529077
59pyrimidine ribonucleoside catabolic process (GO:0046133)2.66388095
60leukocyte degranulation (GO:0043299)2.66162745
61negative regulation of thymocyte apoptotic process (GO:0070244)2.64612681
62regulation of T cell migration (GO:2000404)2.63791695
63respiratory electron transport chain (GO:0022904)2.61528297
64energy coupled proton transport, down electrochemical gradient (GO:0015985)2.59770520
65ATP synthesis coupled proton transport (GO:0015986)2.59770520
66mannosylation (GO:0097502)2.58494624
67electron transport chain (GO:0022900)2.57521183
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57408393
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57241230
70positive regulation of alpha-beta T cell proliferation (GO:0046641)2.56902510
71regulation of type 2 immune response (GO:0002828)2.56440330
72granulocyte activation (GO:0036230)2.56375618
73response to interferon-beta (GO:0035456)2.56193707
74dendritic cell migration (GO:0036336)2.55912391
75negative regulation of interleukin-17 production (GO:0032700)2.55673523
76regulation of integrin-mediated signaling pathway (GO:2001044)2.55125290
77myeloid cell activation involved in immune response (GO:0002275)2.54789951
78antigen processing and presentation via MHC class Ib (GO:0002475)2.54778727
79regulation of mononuclear cell migration (GO:0071675)2.52348941
80aldehyde catabolic process (GO:0046185)2.52310328
81regulation of metalloenzyme activity (GO:0048552)2.52185757
82regulation of lymphocyte migration (GO:2000401)2.51615960
83negative regulation of nitric oxide biosynthetic process (GO:0045019)2.51249109
84mitochondrial calcium ion transport (GO:0006851)2.51245415
85positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.51103935
86positive regulation of type 2 immune response (GO:0002830)2.49866584
87fibril organization (GO:0097435)2.49597390
88response to peptidoglycan (GO:0032494)2.49041804
89GPI anchor biosynthetic process (GO:0006506)2.48890584
90eosinophil migration (GO:0072677)2.48151375
91mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.47935634
92interferon-gamma-mediated signaling pathway (GO:0060333)2.47633629
93positive regulation of mast cell activation involved in immune response (GO:0033008)2.47253432
94positive regulation of mast cell degranulation (GO:0043306)2.47253432
95deoxyribose phosphate biosynthetic process (GO:0046385)2.47210932
962-deoxyribonucleotide biosynthetic process (GO:0009265)2.47210932
97regulation of monocyte chemotaxis (GO:0090025)2.46671440
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.45596369
99superoxide anion generation (GO:0042554)2.44902825
100microglial cell activation (GO:0001774)2.44275385
101negative regulation of leukocyte apoptotic process (GO:2000107)2.44084710
102pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.44070583
103intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.43872505
104regulation of interleukin-8 secretion (GO:2000482)2.43443565
105antigen processing and presentation of endogenous antigen (GO:0019883)2.43006172
106negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.42796526
107negative regulation of myeloid cell apoptotic process (GO:0033033)2.42430057
108positive regulation of T cell migration (GO:2000406)2.40984398
109positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.40696309
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.40296514
111mast cell activation involved in immune response (GO:0002279)2.39515030
112mast cell degranulation (GO:0043303)2.39515030
113protein complex biogenesis (GO:0070271)2.39295971
114positive regulation of B cell differentiation (GO:0045579)2.37648785
115positive regulation of mast cell activation (GO:0033005)2.37523966
116activated T cell proliferation (GO:0050798)2.37495210
117membrane raft organization (GO:0031579)2.37150716
118regulation of interleukin-17 production (GO:0032660)2.36357384
119negative regulation of type 2 immune response (GO:0002829)2.35652674
120positive regulation of lymphocyte migration (GO:2000403)2.35362587
121antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35120130
122cyclooxygenase pathway (GO:0019371)2.34565273
123negative regulation of lipid storage (GO:0010888)2.34253997
124platelet aggregation (GO:0070527)2.33550724
125regulation of natural killer cell mediated immunity (GO:0002715)2.32446508
126regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.32446508
127negative regulation of viral genome replication (GO:0045071)2.32092574
128intracellular pH reduction (GO:0051452)2.31352220
129negative regulation of neurotransmitter transport (GO:0051589)2.29881927
130type I interferon signaling pathway (GO:0060337)2.29845390
131cellular response to type I interferon (GO:0071357)2.29845390
132nucleotide transmembrane transport (GO:1901679)2.28232833
133leukocyte migration involved in inflammatory response (GO:0002523)2.27788202
134negative regulation of calcium ion transport into cytosol (GO:0010523)2.26954847
135G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.24553847
136cytochrome complex assembly (GO:0017004)2.23934166
137positive regulation of T-helper 1 type immune response (GO:0002827)2.23397900
138regulation of antigen processing and presentation (GO:0002577)2.23207500
139response to type I interferon (GO:0034340)2.23184276
140positive regulation of antigen processing and presentation (GO:0002579)2.22627226
141regulation of activation of Janus kinase activity (GO:0010533)2.21804249
142platelet dense granule organization (GO:0060155)2.21734685
143mitochondrial respiratory chain complex I assembly (GO:0032981)2.19553105
144NADH dehydrogenase complex assembly (GO:0010257)2.19553105
145mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.19553105
146regulation of mast cell activation (GO:0033003)2.19537556
147regulation of alpha-beta T cell proliferation (GO:0046640)2.19456685
148pH reduction (GO:0045851)2.19178444
149positive regulation of gamma-delta T cell activation (GO:0046645)2.17617959
150GPI anchor metabolic process (GO:0006505)2.17422347
151glycosphingolipid catabolic process (GO:0046479)2.17072552
152positive regulation of interleukin-17 production (GO:0032740)2.16755197
153cellular defense response (GO:0006968)2.15671005
154respiratory chain complex IV assembly (GO:0008535)2.14632077
155defense response to protozoan (GO:0042832)2.14293507
156transferrin transport (GO:0033572)2.13960338
157regulated secretory pathway (GO:0045055)2.13885065
158negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.12897932
159energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.10601456
160ATP hydrolysis coupled proton transport (GO:0015991)2.10601456
161positive regulation by organism of defense response of other organism involved in symbiotic interact2.10561719
162modulation by symbiont of host immune response (GO:0052553)2.10561719
163positive regulation by symbiont of host defense response (GO:0052509)2.10561719
164modulation by symbiont of host defense response (GO:0052031)2.10561719
165modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.10561719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.37407694
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.28902156
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.01525231
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.85034721
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.76149242
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11185984
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.82254206
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63277232
9TAF15_26573619_Chip-Seq_HEK293_Human2.35097102
10* IRF8_27001747_Chip-Seq_BMDM_Mouse2.22855131
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14448365
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12497506
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10638059
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03717428
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00037973
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.97545125
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96891861
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93788338
19GBX2_23144817_ChIP-Seq_PC3_Human1.87630618
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67588012
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.65733102
22* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63730394
23GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.62504852
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62500342
25RUNX_20019798_ChIP-Seq_JUKART_Human1.62223937
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.62142363
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61312972
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59142600
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56091195
30* RUNX1_22412390_ChIP-Seq_EML_Mouse1.54017989
31VDR_22108803_ChIP-Seq_LS180_Human1.53916118
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49505663
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48845058
34SPI1_23127762_ChIP-Seq_K562_Human1.46246441
35ELK1_19687146_ChIP-ChIP_HELA_Human1.45351192
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43029447
37TFEB_21752829_ChIP-Seq_HELA_Human1.41196192
38ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39758568
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38670387
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38197782
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37940424
42SPI1_23547873_ChIP-Seq_NB4_Human1.37868739
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37500367
44VDR_23849224_ChIP-Seq_CD4+_Human1.36832204
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35058730
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35040446
47P300_19829295_ChIP-Seq_ESCs_Human1.31759319
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30856545
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30844955
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29331878
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29181642
52GATA1_19941826_ChIP-Seq_K562_Human1.29112025
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28539712
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27769586
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27749930
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26936417
57SCL_19346495_ChIP-Seq_HPC-7_Human1.26291571
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25473759
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23170196
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21760130
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20147543
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20103042
63ER_23166858_ChIP-Seq_MCF-7_Human1.19976704
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.19636765
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19430479
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19260033
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19260033
68GATA3_27048872_Chip-Seq_THYMUS_Human1.18269212
69* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18059258
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17391037
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.16233840
72* MYB_26560356_Chip-Seq_TH1_Human1.16176814
73* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15801915
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.14909236
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14631801
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14324330
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13584281
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13425256
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13002389
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12948495
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12885340
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12575849
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11905609
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11801322
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11791289
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11070376
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10790117
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08509927
89GATA1_22025678_ChIP-Seq_K562_Human1.07835131
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06446540
91* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06200853
92EGR1_19032775_ChIP-ChIP_M12_Human1.05806196
93UTX_26944678_Chip-Seq_JUKART_Human1.05436613
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.03286569
95IGF1R_20145208_ChIP-Seq_DFB_Human1.02998022
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02775140
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01733175
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01432538
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00710186
100STAT3_18555785_Chip-Seq_ESCs_Mouse1.00406140
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00388012
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.00012794
103GATA3_26560356_Chip-Seq_TH2_Human0.99573539
104* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99325336
105PRDM14_20953172_ChIP-Seq_ESCs_Human0.98057099
106VDR_24787735_ChIP-Seq_THP-1_Human0.96861965
107GATA2_19941826_ChIP-Seq_K562_Human0.96440083
108SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96317644
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.96230388
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95921412
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95851811
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95792235
113FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94952448
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94231765
115* MYB_26560356_Chip-Seq_TH2_Human0.94039731
116CMYC_18555785_Chip-Seq_ESCs_Mouse0.93803410
117* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92799890
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91686458
119JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91516003
120STAT1_20625510_ChIP-Seq_HELA_Human0.91388493
121P300_18555785_Chip-Seq_ESCs_Mouse0.91073993
122* MAF_26560356_Chip-Seq_TH1_Human0.91005398
123PU_27001747_Chip-Seq_BMDM_Mouse0.90986358
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90555086
125SALL4_22934838_ChIP-ChIP_CD34+_Human0.90481226
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.90192198
127P53_22387025_ChIP-Seq_ESCs_Mouse0.90126280
128CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90103230
129NMYC_18555785_Chip-Seq_ESCs_Mouse0.89743302
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89531317
131GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89291327
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.89176777
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88968853
134NANOG_19829295_ChIP-Seq_ESCs_Human0.88641065
135SOX2_19829295_ChIP-Seq_ESCs_Human0.88641065
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88564005
137SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88548613
138HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87802263
139PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86695979
140EST1_17652178_ChIP-ChIP_JURKAT_Human0.86675199
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84706111
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84619540
143FOXP3_21729870_ChIP-Seq_TREG_Human0.84059358
144VDR_24763502_ChIP-Seq_THP-1_Human0.83826407
145HTT_18923047_ChIP-ChIP_STHdh_Human0.83800164
146* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83360524
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81146336
148ETS1_20019798_ChIP-Seq_JURKAT_Human0.80959146
149SOX2_20726797_ChIP-Seq_SW620_Human0.79340592
150RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79152168
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.78147147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.39770187
2MP0001835_abnormal_antigen_presentation3.38889860
3MP0009785_altered_susceptibility_to3.12185736
4MP0002148_abnormal_hypersensitivity_rea3.09843559
5MP0005671_abnormal_response_to2.98172841
6MP0006082_CNS_inflammation2.83382676
7MP0005000_abnormal_immune_tolerance2.62012635
8MP0000920_abnormal_myelination2.45394911
9MP0002419_abnormal_innate_immunity2.43828726
10MP0005025_abnormal_response_to2.37006031
11MP0008004_abnormal_stomach_pH2.33982949
12MP0006054_spinal_hemorrhage2.26821240
13MP0003880_abnormal_central_pattern2.26433789
14MP0005058_abnormal_lysosome_morphology2.22843069
15MP0005387_immune_system_phenotype2.21051392
16MP0001790_abnormal_immune_system2.21051392
17MP0003436_decreased_susceptibility_to2.18706572
18MP0001905_abnormal_dopamine_level2.10555092
19MP0002723_abnormal_immune_serum2.02407349
20MP0000685_abnormal_immune_system2.02058335
21MP0003806_abnormal_nucleotide_metabolis1.94436872
22MP0005084_abnormal_gallbladder_morpholo1.91653176
23MP0001986_abnormal_taste_sensitivity1.91442442
24MP0002452_abnormal_antigen_presenting1.91115350
25MP0003300_gastrointestinal_ulcer1.86806094
26MP0002420_abnormal_adaptive_immunity1.85710021
27MP0001819_abnormal_immune_cell1.84756027
28MP0001800_abnormal_humoral_immune1.83949846
29MP0002735_abnormal_chemical_nociception1.80959507
30MP0002736_abnormal_nociception_after1.77720134
31MP0001529_abnormal_vocalization1.76138179
32MP0001968_abnormal_touch/_nociception1.63819110
33MP0000372_irregular_coat_pigmentation1.62200966
34MP0010386_abnormal_urinary_bladder1.61576633
35MP0008438_abnormal_cutaneous_collagen1.57519342
36MP0008260_abnormal_autophagy1.54627180
37MP0006276_abnormal_autonomic_nervous1.54270721
38MP0003690_abnormal_glial_cell1.50265582
39MP0005171_absent_coat_pigmentation1.49868057
40MP0001533_abnormal_skeleton_physiology1.48120387
41MP0003136_yellow_coat_color1.47468987
42MP0005310_abnormal_salivary_gland1.47089407
43MP0002405_respiratory_system_inflammati1.46784283
44MP0009763_increased_sensitivity_to1.46007307
45MP0005464_abnormal_platelet_physiology1.45069457
46MP0005409_darkened_coat_color1.41031181
47MP0003279_aneurysm1.40580111
48MP0009379_abnormal_foot_pigmentation1.39865483
49MP0004381_abnormal_hair_follicle1.37161274
50MP0002933_joint_inflammation1.37011629
51MP0009333_abnormal_splenocyte_physiolog1.35259578
52MP0001970_abnormal_pain_threshold1.35065424
53MP0001542_abnormal_bone_strength1.31902035
54MP0000604_amyloidosis1.31545036
55MP0001845_abnormal_inflammatory_respons1.29310767
56MP0005165_increased_susceptibility_to1.27949198
57MP0002722_abnormal_immune_system1.26081403
58MP0005379_endocrine/exocrine_gland_phen1.25656346
59MP0003763_abnormal_thymus_physiology1.24934566
60MP0003186_abnormal_redox_activity1.23022076
61MP0003183_abnormal_peptide_metabolism1.22257814
62MP0000343_altered_response_to1.21999141
63MP0008469_abnormal_protein_level1.21596446
64MP0000716_abnormal_immune_system1.21442024
65MP0001851_eye_inflammation1.21046714
66MP0003828_pulmonary_edema1.20854455
67MP0003191_abnormal_cellular_cholesterol1.20095442
68MP0002733_abnormal_thermal_nociception1.19193774
69MP0001545_abnormal_hematopoietic_system1.18640619
70MP0005397_hematopoietic_system_phenotyp1.18640619
71MP0009764_decreased_sensitivity_to1.16684725
72MP0004142_abnormal_muscle_tone1.14642569
73MP0003329_amyloid_beta_deposits1.14190257
74MP0005390_skeleton_phenotype1.14153647
75MP0004510_myositis1.13939425
76MP0001853_heart_inflammation1.10088484
77MP0002638_abnormal_pupillary_reflex1.08836016
78MP0009765_abnormal_xenobiotic_induced1.06901170
79MP0002734_abnormal_mechanical_nocicepti1.06234566
80MP0005164_abnormal_response_to1.06139405
81MP0004742_abnormal_vestibular_system1.04856903
82MP0002272_abnormal_nervous_system1.04644068
83MP0003172_abnormal_lysosome_physiology1.04592878
84MP0002166_altered_tumor_susceptibility1.03435102
85MP0002064_seizures1.02982010
86MP0002998_abnormal_bone_remodeling1.02148891
87MP0003656_abnormal_erythrocyte_physiolo1.01219799
88MP0002398_abnormal_bone_marrow1.00302157
89MP0002876_abnormal_thyroid_physiology0.98626848
90MP0003075_altered_response_to0.96689391
91MP0002006_tumorigenesis0.96256755
92MP0001188_hyperpigmentation0.96147734
93MP0003795_abnormal_bone_structure0.90872179
94MP0003566_abnormal_cell_adhesion0.90711459
95MP0002132_abnormal_respiratory_system0.90508725
96MP0010155_abnormal_intestine_physiology0.89735374
97MP0003303_peritoneal_inflammation0.88715736
98MP0002429_abnormal_blood_cell0.87918598
99MP0003634_abnormal_glial_cell0.87631912
100MP0004947_skin_inflammation0.87196661
101MP0004270_analgesia0.86872115
102MP0009745_abnormal_behavioral_response0.85769130
103MP0000689_abnormal_spleen_morphology0.85179716
104MP0000490_abnormal_crypts_of0.84657445
105MP0000249_abnormal_blood_vessel0.84276405
106MP0005023_abnormal_wound_healing0.83556749
107MP0002163_abnormal_gland_morphology0.82712567
108MP0001663_abnormal_digestive_system0.82621256
109MP0001958_emphysema0.82385801
110MP0001440_abnormal_grooming_behavior0.81039485
111MP0003633_abnormal_nervous_system0.80972347
112MP0000465_gastrointestinal_hemorrhage0.80246973
113MP0000858_altered_metastatic_potential0.80241922
114MP0003011_delayed_dark_adaptation0.79796914
115MP0000681_abnormal_thyroid_gland0.79382119
116MP0004883_abnormal_blood_vessel0.79334546
117MP0000015_abnormal_ear_pigmentation0.79167134
118MP0001501_abnormal_sleep_pattern0.79116979
119MP0005645_abnormal_hypothalamus_physiol0.78902649
120MP0005166_decreased_susceptibility_to0.78777237
121MP0004782_abnormal_surfactant_physiolog0.78196574
122MP0002277_abnormal_respiratory_mucosa0.77511484
123MP0003448_altered_tumor_morphology0.76782686
124MP0000703_abnormal_thymus_morphology0.76049097
125MP0003866_abnormal_defecation0.75891672
126MP0005275_abnormal_skin_tensile0.74251939
127MP0009840_abnormal_foam_cell0.74225221
128MP0005410_abnormal_fertilization0.74003754
129MP0000230_abnormal_systemic_arterial0.72923825
130MP0003638_abnormal_response/metabolism_0.70293710
131MP0009278_abnormal_bone_marrow0.67212720
132MP0006036_abnormal_mitochondrial_physio0.67053037
133MP0005595_abnormal_vascular_smooth0.63951216
134MP0005167_abnormal_blood-brain_barrier0.63789430
135MP0008873_increased_physiological_sensi0.63356704
136MP0002877_abnormal_melanocyte_morpholog0.62131265
137MP0005075_abnormal_melanosome_morpholog0.59875633
138MP0008874_decreased_physiological_sensi0.59211279
139MP0004272_abnormal_basement_membrane0.58385805
140MP0004147_increased_porphyrin_level0.57599560

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.16021155
2Recurrent abscess formation (HP:0002722)4.63052964
3Increased mean platelet volume (HP:0011877)4.19732153
4Abnormal platelet volume (HP:0011876)4.19350711
5Eczematoid dermatitis (HP:0000976)4.10984115
6Epistaxis (HP:0000421)4.05720985
7Recurrent bacterial skin infections (HP:0005406)3.99719857
8Menorrhagia (HP:0000132)3.92993941
9Vacuolated lymphocytes (HP:0001922)3.82251701
10Elevated erythrocyte sedimentation rate (HP:0003565)3.80601626
11Parakeratosis (HP:0001036)3.73849739
12Acute necrotizing encephalopathy (HP:0006965)3.70181052
13Hypothermia (HP:0002045)3.64524539
14Gingival bleeding (HP:0000225)3.54227666
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.52262670
16Abnormality of macrophages (HP:0004311)3.46538879
17Mitochondrial inheritance (HP:0001427)3.40296823
18Renal Fanconi syndrome (HP:0001994)3.28009632
19Spontaneous hematomas (HP:0007420)3.26579816
20Abnormal mitochondria in muscle tissue (HP:0008316)3.21632979
21Myositis (HP:0100614)3.13415501
22Stomatitis (HP:0010280)3.11082163
23Progressive macrocephaly (HP:0004481)3.03822935
24Neurofibrillary tangles (HP:0002185)3.00215589
25Obstructive lung disease (HP:0006536)2.99816932
26Chronic obstructive pulmonary disease (HP:0006510)2.99816932
27Recurrent skin infections (HP:0001581)2.99214349
28Hepatocellular necrosis (HP:0001404)2.88334541
29Recurrent gram-negative bacterial infections (HP:0005420)2.88249730
30Abnormal platelet function (HP:0011869)2.86079047
31Impaired platelet aggregation (HP:0003540)2.86079047
32Increased hepatocellular lipid droplets (HP:0006565)2.83842931
33Increased IgM level (HP:0003496)2.82643196
34Acute encephalopathy (HP:0006846)2.81192607
35Retrobulbar optic neuritis (HP:0100654)2.79275876
36Optic neuritis (HP:0100653)2.79275876
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.71517208
38Hepatosplenomegaly (HP:0001433)2.70861905
39Abnormality of the vasculature of the conjunctiva (HP:0008054)2.68802046
40Purpura (HP:0000979)2.68344070
41Joint swelling (HP:0001386)2.67972593
42Encephalitis (HP:0002383)2.67013354
43Autoimmune hemolytic anemia (HP:0001890)2.63522145
44Increased CSF lactate (HP:0002490)2.59211312
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49200247
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49200247
473-Methylglutaconic aciduria (HP:0003535)2.49083843
48Orchitis (HP:0100796)2.48110670
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.47575071
50Nausea (HP:0002018)2.47414505
51Autoimmune thrombocytopenia (HP:0001973)2.45399370
52Conjunctival telangiectasia (HP:0000524)2.45085560
53Congenital ichthyosiform erythroderma (HP:0007431)2.42511880
54Systemic lupus erythematosus (HP:0002725)2.41266264
55Pulmonary infiltrates (HP:0002113)2.40984969
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.40534968
57Lipid accumulation in hepatocytes (HP:0006561)2.36691146
58Abnormal hair whorl (HP:0010721)2.35991741
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35312036
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32438688
61Hepatic necrosis (HP:0002605)2.30151868
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29979375
63Exertional dyspnea (HP:0002875)2.27869131
64Axonal loss (HP:0003447)2.27714374
65Hypergammaglobulinemia (HP:0010702)2.27311875
66Abnormality of T cells (HP:0002843)2.26967108
67Increased cerebral lipofuscin (HP:0011813)2.26954307
68Eosinophilia (HP:0001880)2.26206140
69Abnormality of glycolipid metabolism (HP:0010969)2.25056640
70Abnormality of liposaccharide metabolism (HP:0010968)2.25056640
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.25056640
72Optic disc pallor (HP:0000543)2.24309905
73Patchy hypopigmentation of hair (HP:0011365)2.22568002
74Meningitis (HP:0001287)2.22314021
75Mediastinal lymphadenopathy (HP:0100721)2.22271490
76Vasculitis (HP:0002633)2.19640375
77Chronic mucocutaneous candidiasis (HP:0002728)2.18916473
78Recurrent cutaneous fungal infections (HP:0011370)2.18916473
79Gangrene (HP:0100758)2.18604124
80Increased serum ferritin (HP:0003281)2.17010061
81Dysostosis multiplex (HP:0000943)2.16548192
82Peripheral hypomyelination (HP:0007182)2.15833507
83Neuroendocrine neoplasm (HP:0100634)2.15321255
84Leukodystrophy (HP:0002415)2.15184931
85Recurrent fungal infections (HP:0002841)2.14127616
86Abnormality of the prostate (HP:0008775)2.13508081
87Petechiae (HP:0000967)2.11286686
88Chronic otitis media (HP:0000389)2.11021725
89Abnormality of renal resorption (HP:0011038)2.10854393
90Granulocytopenia (HP:0001913)2.10006692
91Anorexia (HP:0002039)2.08192010
92Glomerulopathy (HP:0100820)2.08072764
93Pulmonary fibrosis (HP:0002206)2.07086265
94Cerebral hemorrhage (HP:0001342)2.07001793
95Severe combined immunodeficiency (HP:0004430)2.04576398
96Progressive neurologic deterioration (HP:0002344)2.04552845
97Recurrent pneumonia (HP:0006532)2.04447115
98Gastrointestinal infarctions (HP:0005244)2.01984927
99Polyneuropathy (HP:0001271)2.00143004
100Generalized aminoaciduria (HP:0002909)1.99865447
101Urticaria (HP:0001025)1.99612582
102Abnormality of iron homeostasis (HP:0011031)1.99504110
103Loss of speech (HP:0002371)1.95929859
104Type I transferrin isoform profile (HP:0003642)1.95595239
105Arterial thrombosis (HP:0004420)1.95100148
106White forelock (HP:0002211)1.94840021
107Respiratory failure (HP:0002878)1.94535786
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94479841
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.94479841
110Autoamputation (HP:0001218)1.93488228
111Increased intramyocellular lipid droplets (HP:0012240)1.93355475
112Abnormality of T cell number (HP:0011839)1.93271942
113Abnormal pupillary function (HP:0007686)1.91552803
114Abnormal delayed hypersensitivity skin test (HP:0002963)1.90811348
115Pheochromocytoma (HP:0002666)1.88212481
116Gingivitis (HP:0000230)1.87930303
117Keratoconjunctivitis sicca (HP:0001097)1.85004387
118Premature loss of primary teeth (HP:0006323)1.83789023
119T lymphocytopenia (HP:0005403)1.83173058
120Hyperlipoproteinemia (HP:0010980)1.82885605
121Abnormality of secondary sexual hair (HP:0009888)1.81768713
122Abnormality of the axillary hair (HP:0100134)1.81768713
123Bruising susceptibility (HP:0000978)1.81680064
124Dyschromatopsia (HP:0007641)1.80051673
125Erythema (HP:0010783)1.79789194
126Abnormality of T cell physiology (HP:0011840)1.79439580
127Myocardial infarction (HP:0001658)1.78551704
128Mutism (HP:0002300)1.77980392
129Basal ganglia calcification (HP:0002135)1.77545298
130Chest pain (HP:0100749)1.76692370
131Disinhibition (HP:0000734)1.76545979
132Segmental peripheral demyelination/remyelination (HP:0003481)1.76194470
133Medial flaring of the eyebrow (HP:0010747)1.76151784
134IgG deficiency (HP:0004315)1.75971244
135Exercise intolerance (HP:0003546)1.75432307
136Amaurosis fugax (HP:0100576)1.74882410
137Recurrent viral infections (HP:0004429)1.74798978
138Leukocytosis (HP:0001974)1.74738820
139Prolonged neonatal jaundice (HP:0006579)1.74613091
140Abnormality of eosinophils (HP:0001879)1.73521519
141Sensory axonal neuropathy (HP:0003390)1.72907842
142Amyloidosis (HP:0011034)1.72491287
143Hemoptysis (HP:0002105)1.71850782
144IgM deficiency (HP:0002850)1.71652283
145Panhypogammaglobulinemia (HP:0003139)1.71260590
146Cerebral inclusion bodies (HP:0100314)1.70242934
147Keratoconjunctivitis (HP:0001096)1.69678431
148Episodic fever (HP:0001954)1.69270668
149Xerostomia (HP:0000217)1.68585008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.06950004
2MAP3K122.92282393
3TXK2.79123287
4CASK2.49193540
5MST42.43783722
6PBK2.42654573
7IRAK42.39359836
8TESK12.32822603
9RIPK42.32335956
10STK162.05540320
11NME22.05311341
12MAP3K142.03091626
13ARAF2.00898509
14PIM22.00214840
15STK391.96059238
16GRK71.91468000
17ADRBK21.86959164
18IKBKE1.84086895
19BMPR1B1.82797233
20MAP4K11.82459812
21MAPKAPK51.82197190
22TBK11.79197262
23KIT1.69194456
24EIF2AK11.64170668
25TNIK1.57522062
26OXSR11.57189283
27TEC1.53132435
28MYLK1.41362625
29TRIM281.39206103
30EPHB11.37928752
31CDK191.37137029
32BMPR21.36677591
33IRAK31.35358510
34BMX1.26612134
35BCR1.23962680
36MAP4K21.23378886
37CLK11.22606745
38FES1.19219206
39LIMK11.19128530
40SYK1.19082141
41GRK51.18672682
42IRAK11.17975581
43ZAP701.15944404
44TYK21.14844443
45ITK1.14590815
46LCK1.13966733
47MUSK1.13711679
48MAP3K31.11082662
49IRAK21.06851434
50TESK21.06582546
51TAOK21.05379097
52SIK31.01706183
53IKBKB1.00670774
54LYN0.99142698
55FGR0.98210421
56BCKDK0.96588461
57JAK30.96498805
58KDR0.94368108
59MAPKAPK30.93993669
60PAK40.90170440
61DAPK10.89632943
62BTK0.89142580
63CSNK1G20.88377553
64MAP2K70.87527526
65PRKCQ0.86334643
66NLK0.85273218
67MAP3K110.85075281
68NTRK10.84550911
69PRPF4B0.83723525
70SCYL20.83313793
71NEK60.80868116
72TLK10.80622606
73DDR20.78563616
74MAP3K50.76881149
75CSNK1G30.75272112
76VRK10.73985882
77STK240.73817194
78PKN10.72115569
79CSK0.70940213
80PAK10.70166077
81NUAK10.68658986
82PLK20.68468151
83DAPK30.68373389
84TRPM70.67692232
85TIE10.67339037
86PDK20.65648316
87TNK20.65573915
88EPHA30.65100069
89CSF1R0.64212465
90ACVR1B0.63393444
91JAK20.62967386
92CAMK2B0.62513268
93MATK0.62297544
94ERN10.61388724
95ABL20.61200673
96PRKCE0.60903170
97MAP3K130.59070203
98ADRBK10.58594703
99JAK10.57677394
100MAPK150.57459471
101HCK0.57349521
102ROCK20.56738574
103PRKCD0.56348928
104YES10.55826481
105MAPK130.54898713
106CDK80.54860152
107EIF2AK30.54251542
108STK100.51999252
109ABL10.51974466
110ERBB30.51241448
111RPS6KA50.49782851
112TAOK30.49609740
113CSNK1A1L0.47623918
114CAMK2A0.47378998
115NME10.46865114
116CAMKK20.46698803
117PTK2B0.46356177
118BUB10.43910550
119FYN0.43634443
120MARK30.43152155
121CAMK2D0.42941645
122CSNK1G10.42732622
123PIK3CG0.42369386
124MAPK40.42189246
125ILK0.41662811
126CAMK2G0.41132732
127DYRK20.40588381
128GRK10.39932509
129STK30.39370439
130MOS0.38784982
131DYRK30.38679295
132FGFR40.38478660
133EGFR0.37929675
134GRK60.37812892
135TGFBR20.37532461
136LMTK20.37166335
137MAPKAPK20.36826642
138CDK140.36299588
139PIM10.36014249
140IGF1R0.35542019

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.56714714
2Protein export_Homo sapiens_hsa030603.07899652
3Parkinsons disease_Homo sapiens_hsa050122.66934527
4Graft-versus-host disease_Homo sapiens_hsa053322.56115775
5Rheumatoid arthritis_Homo sapiens_hsa053232.47963306
6Proteasome_Homo sapiens_hsa030502.34472996
7Alzheimers disease_Homo sapiens_hsa050102.24395448
8Collecting duct acid secretion_Homo sapiens_hsa049662.23886506
9Fatty acid elongation_Homo sapiens_hsa000622.14550451
10Allograft rejection_Homo sapiens_hsa053302.11723584
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08240119
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.96864353
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95283027
14Steroid biosynthesis_Homo sapiens_hsa001001.94291953
15Primary immunodeficiency_Homo sapiens_hsa053401.87186798
16Phagosome_Homo sapiens_hsa041451.84831518
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83813444
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78953772
19Ribosome_Homo sapiens_hsa030101.72873666
20Lysosome_Homo sapiens_hsa041421.66308088
21Autoimmune thyroid disease_Homo sapiens_hsa053201.62239633
22Leishmaniasis_Homo sapiens_hsa051401.60229187
23Other glycan degradation_Homo sapiens_hsa005111.59819712
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57813519
25Asthma_Homo sapiens_hsa053101.57535136
26Huntingtons disease_Homo sapiens_hsa050161.55057040
27Staphylococcus aureus infection_Homo sapiens_hsa051501.52944643
28Vibrio cholerae infection_Homo sapiens_hsa051101.52884917
29Malaria_Homo sapiens_hsa051441.50648179
30Pertussis_Homo sapiens_hsa051331.49009608
31Sphingolipid metabolism_Homo sapiens_hsa006001.48324201
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.46973616
33Ether lipid metabolism_Homo sapiens_hsa005651.46169482
34Hematopoietic cell lineage_Homo sapiens_hsa046401.41914328
35Viral myocarditis_Homo sapiens_hsa054161.38498452
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34381562
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27437923
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13646282
39Tuberculosis_Homo sapiens_hsa051521.10086806
40Salmonella infection_Homo sapiens_hsa051321.06722535
41Measles_Homo sapiens_hsa051621.04734264
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04638975
43Type I diabetes mellitus_Homo sapiens_hsa049401.02986248
44Herpes simplex infection_Homo sapiens_hsa051681.01550886
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.00628677
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99809494
47Osteoclast differentiation_Homo sapiens_hsa043800.99773352
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97913108
49Histidine metabolism_Homo sapiens_hsa003400.97369942
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95005764
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92631240
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91887187
53Serotonergic synapse_Homo sapiens_hsa047260.91399922
54Antigen processing and presentation_Homo sapiens_hsa046120.90170236
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89457499
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88835013
57Sulfur metabolism_Homo sapiens_hsa009200.87145626
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86699616
59T cell receptor signaling pathway_Homo sapiens_hsa046600.84513296
60Shigellosis_Homo sapiens_hsa051310.82925086
61Arachidonic acid metabolism_Homo sapiens_hsa005900.82857091
62African trypanosomiasis_Homo sapiens_hsa051430.82407968
63Glutathione metabolism_Homo sapiens_hsa004800.81880419
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81044098
65Endocytosis_Homo sapiens_hsa041440.80204917
66Chemokine signaling pathway_Homo sapiens_hsa040620.78268972
67Legionellosis_Homo sapiens_hsa051340.77281108
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75504760
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75259322
70Synaptic vesicle cycle_Homo sapiens_hsa047210.73778944
71RNA polymerase_Homo sapiens_hsa030200.71603723
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.66791242
73Phototransduction_Homo sapiens_hsa047440.64191549
74Regulation of autophagy_Homo sapiens_hsa041400.60057095
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58948452
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58029610
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58004569
78Epstein-Barr virus infection_Homo sapiens_hsa051690.56815964
79B cell receptor signaling pathway_Homo sapiens_hsa046620.56471110
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56205371
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.56148606
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.54577816
83Nitrogen metabolism_Homo sapiens_hsa009100.52536927
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50812895
85Mismatch repair_Homo sapiens_hsa034300.48767374
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47612918
87Hepatitis B_Homo sapiens_hsa051610.47505288
88Morphine addiction_Homo sapiens_hsa050320.45050009
89Cardiac muscle contraction_Homo sapiens_hsa042600.42994280
90Linoleic acid metabolism_Homo sapiens_hsa005910.42826723
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42767815
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42751330
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42213979
94Galactose metabolism_Homo sapiens_hsa000520.40248643
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39247839
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38800480
97Folate biosynthesis_Homo sapiens_hsa007900.37385115
98Taste transduction_Homo sapiens_hsa047420.36159779
99Pyrimidine metabolism_Homo sapiens_hsa002400.36084958
100Renin-angiotensin system_Homo sapiens_hsa046140.35654073
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33727185
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33628809
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33404152
104Toxoplasmosis_Homo sapiens_hsa051450.32905301
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31620821
106Hepatitis C_Homo sapiens_hsa051600.31579537
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.31105534
108Influenza A_Homo sapiens_hsa051640.30835035
109Metabolic pathways_Homo sapiens_hsa011000.30135367
110Platelet activation_Homo sapiens_hsa046110.28860377
111TNF signaling pathway_Homo sapiens_hsa046680.28388450
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27809540
113ECM-receptor interaction_Homo sapiens_hsa045120.27784402
114Amoebiasis_Homo sapiens_hsa051460.26386095
115Mineral absorption_Homo sapiens_hsa049780.26289902
116Prion diseases_Homo sapiens_hsa050200.25907071
117Nicotine addiction_Homo sapiens_hsa050330.25777571
118Apoptosis_Homo sapiens_hsa042100.24786730
119Peroxisome_Homo sapiens_hsa041460.24742684
120Tyrosine metabolism_Homo sapiens_hsa003500.24559860
121Sulfur relay system_Homo sapiens_hsa041220.16724819
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14688424
123Viral carcinogenesis_Homo sapiens_hsa052030.13268838

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