TMEM50B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)4.29338770
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.21161993
3retinal cone cell development (GO:0046549)4.17494266
4synaptic vesicle exocytosis (GO:0016079)4.17071709
5regulation of synaptic vesicle exocytosis (GO:2000300)4.13270777
6neuronal action potential propagation (GO:0019227)3.88764973
7epithelial cilium movement (GO:0003351)3.78675335
8regulation of synaptic vesicle transport (GO:1902803)3.77523461
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73395848
10regulation of cilium movement (GO:0003352)3.69356067
11energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.66578209
12ATP hydrolysis coupled proton transport (GO:0015991)3.66578209
13transferrin transport (GO:0033572)3.66455209
14cilium movement (GO:0003341)3.53675571
15vitamin transmembrane transport (GO:0035461)3.44885395
16long-chain fatty acid biosynthetic process (GO:0042759)3.42344501
17cellular ketone body metabolic process (GO:0046950)3.41094819
18axonemal dynein complex assembly (GO:0070286)3.40263432
19ferric iron transport (GO:0015682)3.36362782
20trivalent inorganic cation transport (GO:0072512)3.36362782
21ketone body metabolic process (GO:1902224)3.35007720
22cilium or flagellum-dependent cell motility (GO:0001539)3.32034402
23rRNA catabolic process (GO:0016075)3.31236021
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.29031409
25fucose catabolic process (GO:0019317)3.26822235
26L-fucose metabolic process (GO:0042354)3.26822235
27L-fucose catabolic process (GO:0042355)3.26822235
28piRNA metabolic process (GO:0034587)3.26372447
29phagosome maturation (GO:0090382)3.24770419
30xenobiotic catabolic process (GO:0042178)3.23948025
31neuron cell-cell adhesion (GO:0007158)3.23021992
32positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22847177
33cellular potassium ion homeostasis (GO:0030007)3.21825607
34chaperone-mediated protein transport (GO:0072321)3.18511531
35regulation of protein glycosylation (GO:0060049)3.17312723
36glutamate secretion (GO:0014047)3.17242964
37S-adenosylmethionine metabolic process (GO:0046500)3.12777629
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06446428
39vocalization behavior (GO:0071625)3.01407199
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00599713
41preassembly of GPI anchor in ER membrane (GO:0016254)2.96997781
42mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.96375028
43positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.96375028
44regulation of memory T cell differentiation (GO:0043380)2.93548113
45positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93134299
46one-carbon compound transport (GO:0019755)2.92609229
47cilium morphogenesis (GO:0060271)2.88011121
48sodium ion export (GO:0071436)2.87952413
49negative regulation of dendrite morphogenesis (GO:0050774)2.87390172
50mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.86839700
51gamma-aminobutyric acid signaling pathway (GO:0007214)2.84268623
52sleep (GO:0030431)2.83833979
53protein K11-linked deubiquitination (GO:0035871)2.81612544
54synaptic vesicle maturation (GO:0016188)2.81240506
55cerebellar granule cell differentiation (GO:0021707)2.80670776
56intraciliary transport (GO:0042073)2.79805235
57CDP-diacylglycerol metabolic process (GO:0046341)2.78957620
58protein localization to cilium (GO:0061512)2.78191316
59protein complex biogenesis (GO:0070271)2.76194764
60GMP metabolic process (GO:0046037)2.75117846
61neuron-neuron synaptic transmission (GO:0007270)2.74857320
62locomotory exploration behavior (GO:0035641)2.74019702
63neuromuscular process controlling posture (GO:0050884)2.72724674
64negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.72284800
65response to pheromone (GO:0019236)2.72196559
66synaptic vesicle transport (GO:0048489)2.72014559
67establishment of synaptic vesicle localization (GO:0097480)2.72014559
68signal peptide processing (GO:0006465)2.71724166
69neurotransmitter catabolic process (GO:0042135)2.71542779
70glutamate receptor signaling pathway (GO:0007215)2.71482417
71parturition (GO:0007567)2.69257019
72C-terminal protein lipidation (GO:0006501)2.69020118
73ionotropic glutamate receptor signaling pathway (GO:0035235)2.68837499
74NADH metabolic process (GO:0006734)2.68716990
75regulation of amyloid precursor protein catabolic process (GO:1902991)2.66641861
76positive regulation of potassium ion transmembrane transport (GO:1901381)2.66132661
77protein localization to synapse (GO:0035418)2.65548100
78dopamine transport (GO:0015872)2.65527548
79organelle membrane fusion (GO:0090174)2.65435910
80ER overload response (GO:0006983)2.65233522
81nonmotile primary cilium assembly (GO:0035058)2.64807466
82mannosylation (GO:0097502)2.64615459
83proline transport (GO:0015824)2.64415679
84negative regulation of inclusion body assembly (GO:0090084)2.63780474
85phosphatidylinositol acyl-chain remodeling (GO:0036149)2.61832515
86synaptic transmission, glutamatergic (GO:0035249)2.61717076
87regulation of synapse structural plasticity (GO:0051823)2.61038647
88detection of light stimulus involved in sensory perception (GO:0050962)2.61035256
89detection of light stimulus involved in visual perception (GO:0050908)2.61035256
90long-term synaptic potentiation (GO:0060291)2.60654083
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60268832
92autophagic vacuole assembly (GO:0000045)2.59717277
93cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59606725
94response to nitrosative stress (GO:0051409)2.58674852
95detection of calcium ion (GO:0005513)2.58648583
96regulation of neurotransmitter secretion (GO:0046928)2.58581202
97GPI anchor metabolic process (GO:0006505)2.58376065
98male meiosis (GO:0007140)2.56630822
99cilium organization (GO:0044782)2.56178379
100regulation of microtubule-based movement (GO:0060632)2.55784778
101neurotransmitter secretion (GO:0007269)2.55205263
102potassium ion homeostasis (GO:0055075)2.54823598
103regulation of vesicle fusion (GO:0031338)2.54361767
104positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.53782082
105DNA methylation involved in gamete generation (GO:0043046)2.50698000
106positive regulation of potassium ion transport (GO:0043268)2.50453352
107regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.50453301
108positive regulation of synapse maturation (GO:0090129)2.50450226
109positive regulation of digestive system process (GO:0060456)2.49791943
110regulation of neurotransmitter transport (GO:0051588)2.49196070
111thyroid hormone metabolic process (GO:0042403)2.48494117
112autophagic vacuole fusion (GO:0000046)2.47900538
113regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47892518
114behavioral response to nicotine (GO:0035095)2.47772435
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.47726181
116neural tube formation (GO:0001841)2.47227957
117G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47189691
118benzene-containing compound metabolic process (GO:0042537)2.47163220
119membrane depolarization during action potential (GO:0086010)2.46744540
120regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.46505464
121positive regulation of mitochondrial fission (GO:0090141)2.46486768
122platelet dense granule organization (GO:0060155)2.45945770
123respiratory chain complex IV assembly (GO:0008535)2.45540137
124long term synaptic depression (GO:0060292)2.45352200
125protein neddylation (GO:0045116)2.44717670
126C-terminal protein amino acid modification (GO:0018410)2.44281761
127cilium assembly (GO:0042384)2.43808207
128regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.42713624
129calcium-mediated signaling using intracellular calcium source (GO:0035584)2.42390691
130pH reduction (GO:0045851)2.42231546
131photoreceptor cell maintenance (GO:0045494)2.41554640
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.41248295
133NADH dehydrogenase complex assembly (GO:0010257)2.41248295
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.41248295
135neurotransmitter transport (GO:0006836)2.40059089
136glycosylceramide metabolic process (GO:0006677)2.40052233
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.38383423
138GPI anchor biosynthetic process (GO:0006506)2.37818741
139positive regulation of mitochondrial membrane permeability (GO:0035794)2.37783881
140establishment of vesicle localization (GO:0051650)2.37378171
141axon ensheathment in central nervous system (GO:0032291)2.37053413
142central nervous system myelination (GO:0022010)2.37053413
143striatum development (GO:0021756)2.36901720
144mitochondrial respiratory chain complex assembly (GO:0033108)2.36344467
145fatty acid elongation (GO:0030497)2.36079281
146negative regulation of neurotransmitter transport (GO:0051589)2.35954310
147water-soluble vitamin biosynthetic process (GO:0042364)2.35113962
148regulation of glucokinase activity (GO:0033131)2.34996128
149regulation of hexokinase activity (GO:1903299)2.34996128
150membrane repolarization (GO:0086009)2.34744144
151regulation of glutamate receptor signaling pathway (GO:1900449)2.34333481
152transmission of nerve impulse (GO:0019226)2.34194765
153glycolipid biosynthetic process (GO:0009247)2.33803463
154regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.33728169
155regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.33728169
156mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.33177341
157short-chain fatty acid metabolic process (GO:0046459)2.32935481
158DNA deamination (GO:0045006)2.32040696
159negative regulation of cation channel activity (GO:2001258)2.31053460
160detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.30962786
161neurotransmitter metabolic process (GO:0042133)2.30818962
162amino acid salvage (GO:0043102)2.30655234
163L-methionine salvage (GO:0071267)2.30655234
164L-methionine biosynthetic process (GO:0071265)2.30655234
165protein polyglutamylation (GO:0018095)2.30004201
166regulation of neuronal synaptic plasticity (GO:0048168)2.29256884
167long-term memory (GO:0007616)2.29000058
168response to auditory stimulus (GO:0010996)2.28727771
169negative regulation of mast cell activation (GO:0033004)2.28686079
170intracellular pH reduction (GO:0051452)2.28538477
171positive regulation of sodium ion transport (GO:0010765)2.28490932
172presynaptic membrane assembly (GO:0097105)2.28009648
173cell communication by electrical coupling (GO:0010644)2.27948147
174L-amino acid import (GO:0043092)2.27764949
175proton transport (GO:0015992)2.27581151
176exploration behavior (GO:0035640)2.27517439
177regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.26956201
178regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.26611500
179dopamine biosynthetic process (GO:0042416)2.26406430
180regulation of neurotransmitter uptake (GO:0051580)2.26404642
181retinal rod cell development (GO:0046548)2.26270292
182regulation of exocytosis (GO:0017157)2.25930351
183glycosphingolipid biosynthetic process (GO:0006688)2.24790121
184phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.24038169
185cytochrome complex assembly (GO:0017004)2.23997873
186neurotransmitter biosynthetic process (GO:0042136)2.23699003
187photoreceptor cell development (GO:0042461)2.23525212
188hydrogen transport (GO:0006818)2.23253907
189negative regulation of neurological system process (GO:0031645)2.22309464
190cardiolipin metabolic process (GO:0032048)2.21480754
191thyroid hormone generation (GO:0006590)2.20680201
192nucleotide transmembrane transport (GO:1901679)2.20451144
193left/right axis specification (GO:0070986)2.19662863
194negative regulation of response to food (GO:0032096)2.19484660
195negative regulation of appetite (GO:0032099)2.19484660
196organic cation transport (GO:0015695)2.18635239
197indolalkylamine metabolic process (GO:0006586)2.18468914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.62480074
2GBX2_23144817_ChIP-Seq_PC3_Human2.85940013
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82296184
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76987156
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63794473
6REST_21632747_ChIP-Seq_MESCs_Mouse2.59995009
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49991743
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.47734454
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40159061
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34894933
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31079411
12IGF1R_20145208_ChIP-Seq_DFB_Human2.29066084
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20099118
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.19142334
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07163053
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06774296
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05259660
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98479795
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96673120
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.92140586
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91070138
22FUS_26573619_Chip-Seq_HEK293_Human1.86149307
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83471865
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83471865
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.82467690
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80420034
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77816256
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.74717452
29BCAT_22108803_ChIP-Seq_LS180_Human1.72464101
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71446962
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67953477
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66029922
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.65767573
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.63172246
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62828556
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.61701728
37CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.60557757
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56379117
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55859770
40TAF15_26573619_Chip-Seq_HEK293_Human1.55432367
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55273999
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.55164624
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55090377
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54108551
45CBP_20019798_ChIP-Seq_JUKART_Human1.53820145
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53820145
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.52070497
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51313231
49SMAD4_21799915_ChIP-Seq_A2780_Human1.51094262
50ZNF274_21170338_ChIP-Seq_K562_Hela1.50706967
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49941577
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48205056
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48074063
54EWS_26573619_Chip-Seq_HEK293_Human1.47645180
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47595770
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45472535
57IRF1_19129219_ChIP-ChIP_H3396_Human1.44268409
58DROSHA_22980978_ChIP-Seq_HELA_Human1.43074364
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.43066480
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42857029
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.42857029
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41484946
63ER_23166858_ChIP-Seq_MCF-7_Human1.41323366
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.39541889
65AR_25329375_ChIP-Seq_VCAP_Human1.37320745
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36821454
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36463787
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35796973
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35676919
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35015935
71VDR_22108803_ChIP-Seq_LS180_Human1.34702183
72AR_20517297_ChIP-Seq_VCAP_Human1.33989636
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.33169620
74P300_19829295_ChIP-Seq_ESCs_Human1.31444410
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31245052
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30119768
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28353704
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28188526
79TP53_22573176_ChIP-Seq_HFKS_Human1.27919686
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27843488
81TCF4_22108803_ChIP-Seq_LS180_Human1.27301238
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23980233
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.22915572
84CDX2_22108803_ChIP-Seq_LS180_Human1.20360766
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19876572
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.19612440
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18620781
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18160731
89GATA3_26560356_Chip-Seq_TH2_Human1.17518180
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.17224507
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16235704
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15927923
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15024176
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.14212417
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12826651
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.12087515
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11196841
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10486136
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10114324
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.10011853
101P53_22387025_ChIP-Seq_ESCs_Mouse1.08791419
102RUNX_20019798_ChIP-Seq_JUKART_Human1.07103060
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07070189
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.05414792
105GATA3_21878914_ChIP-Seq_MCF-7_Human1.05160745
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03237340
107FOXH1_21741376_ChIP-Seq_EPCs_Human1.02805269
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02752003
109RUNX2_22187159_ChIP-Seq_PCA_Human1.01999094
110TET1_21490601_ChIP-Seq_MESCs_Mouse1.01798154
111NCOR_22424771_ChIP-Seq_293T_Human1.01768929
112AR_21572438_ChIP-Seq_LNCaP_Human1.01623525
113GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00963938
114AHR_22903824_ChIP-Seq_MCF-7_Human1.00917602
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00674989
116NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00606304
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.99564798
118STAT3_18555785_Chip-Seq_ESCs_Mouse0.99410361
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99263483
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99018954
121CBX2_27304074_Chip-Seq_ESCs_Mouse0.98954898
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98890248
123ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98792366
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98258913
125TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97285508
126IRF8_21731497_ChIP-ChIP_J774_Mouse0.97219470
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96535107
128PHF8_20622853_ChIP-Seq_HELA_Human0.96279238
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96113577
130STAT3_23295773_ChIP-Seq_U87_Human0.95907460
131ETV1_20927104_ChIP-Seq_GIST48_Human0.94674473
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94393232
133RNF2_27304074_Chip-Seq_NSC_Mouse0.93999889
134* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93660245
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93379776
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92693748
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.92035960
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.91144732
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90810862
140SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90305368
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89759151
142SMAD3_21741376_ChIP-Seq_EPCs_Human0.89529681
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89312483
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88419905
145FOXH1_21741376_ChIP-Seq_ESCs_Human0.88370973
146FLI1_21867929_ChIP-Seq_TH2_Mouse0.86777326
147CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85771910
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.81798886
149NANOG_19829295_ChIP-Seq_ESCs_Human0.81273634
150SOX2_19829295_ChIP-Seq_ESCs_Human0.81273634
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80970228
152TCF4_23295773_ChIP-Seq_U87_Human0.80927454
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.80834263
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79864293
155CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78190165
156JUN_21703547_ChIP-Seq_K562_Human0.77680674
157ESR2_21235772_ChIP-Seq_MCF-7_Human0.77447199
158SOX2_18555785_Chip-Seq_ESCs_Mouse0.77132838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.91551866
2MP0004859_abnormal_synaptic_plasticity3.69677260
3MP0009046_muscle_twitch3.07737037
4MP0004270_analgesia3.07719442
5MP0003635_abnormal_synaptic_transmissio2.94715592
6MP0001968_abnormal_touch/_nociception2.81714689
7MP0002064_seizures2.72073470
8MP0002735_abnormal_chemical_nociception2.67223513
9MP0003195_calcinosis2.64738229
10MP0002736_abnormal_nociception_after2.62956685
11MP0002734_abnormal_mechanical_nocicepti2.60919061
12MP0003329_amyloid_beta_deposits2.59105189
13MP0005075_abnormal_melanosome_morpholog2.56802222
14MP0002272_abnormal_nervous_system2.48383601
15MP0001529_abnormal_vocalization2.47841644
16MP0004147_increased_porphyrin_level2.47570830
17MP0008260_abnormal_autophagy2.43561054
18MP0009745_abnormal_behavioral_response2.39756332
19MP0002733_abnormal_thermal_nociception2.35571080
20MP0001440_abnormal_grooming_behavior2.31194012
21MP0002063_abnormal_learning/memory/cond2.30361721
22MP0000372_irregular_coat_pigmentation2.29541047
23MP0001970_abnormal_pain_threshold2.29077377
24MP0005058_abnormal_lysosome_morphology2.07652935
25MP0002572_abnormal_emotion/affect_behav2.06542638
26MP0002102_abnormal_ear_morphology2.03642120
27MP0008875_abnormal_xenobiotic_pharmacok2.03385415
28MP0001486_abnormal_startle_reflex2.02288255
29MP0001501_abnormal_sleep_pattern2.02057874
30MP0003787_abnormal_imprinting1.99073369
31MP0008877_abnormal_DNA_methylation1.92442983
32MP0003011_delayed_dark_adaptation1.89300162
33MP0001905_abnormal_dopamine_level1.82979253
34MP0003724_increased_susceptibility_to1.81312162
35MP0003183_abnormal_peptide_metabolism1.80360508
36MP0002067_abnormal_sensory_capabilities1.79350790
37MP0003879_abnormal_hair_cell1.73335218
38MP0004782_abnormal_surfactant_physiolog1.71873946
39MP0002837_dystrophic_cardiac_calcinosis1.70328443
40MP0000013_abnormal_adipose_tissue1.69469089
41MP0002876_abnormal_thyroid_physiology1.67120151
42MP0005253_abnormal_eye_physiology1.66201608
43MP0005085_abnormal_gallbladder_physiolo1.62565091
44MP0002909_abnormal_adrenal_gland1.58003782
45MP0006276_abnormal_autonomic_nervous1.57213457
46MP0000920_abnormal_myelination1.56413010
47MP0005360_urolithiasis1.56286143
48MP0008569_lethality_at_weaning1.54735282
49MP0001984_abnormal_olfaction1.53363760
50MP0010386_abnormal_urinary_bladder1.52052452
51MP0002184_abnormal_innervation1.45779587
52MP0003690_abnormal_glial_cell1.44716292
53MP0005423_abnormal_somatic_nervous1.42879905
54MP0004885_abnormal_endolymph1.40789180
55MP0004858_abnormal_nervous_system1.40673875
56MP0000569_abnormal_digit_pigmentation1.38634149
57MP0000604_amyloidosis1.38023454
58MP0002822_catalepsy1.36656107
59MP0003634_abnormal_glial_cell1.36608937
60MP0001502_abnormal_circadian_rhythm1.35728348
61MP0001764_abnormal_homeostasis1.34778521
62MP0000383_abnormal_hair_follicle1.34412837
63MP0010329_abnormal_lipoprotein_level1.34024431
64MP0004924_abnormal_behavior1.33254833
65MP0005386_behavior/neurological_phenoty1.33254833
66MP0006036_abnormal_mitochondrial_physio1.32411843
67MP0003252_abnormal_bile_duct1.31519793
68MP0004742_abnormal_vestibular_system1.29188044
69MP0004036_abnormal_muscle_relaxation1.28565922
70MP0002653_abnormal_ependyma_morphology1.28289469
71MP0002229_neurodegeneration1.24940811
72MP0005310_abnormal_salivary_gland1.24047493
73MP0004043_abnormal_pH_regulation1.23508603
74MP0008872_abnormal_physiological_respon1.23377601
75MP0005551_abnormal_eye_electrophysiolog1.23271679
76MP0004084_abnormal_cardiac_muscle1.23086288
77MP0008775_abnormal_heart_ventricle1.22224667
78MP0005636_abnormal_mineral_homeostasis1.21819168
79MP0001765_abnormal_ion_homeostasis1.20869409
80MP0002066_abnormal_motor_capabilities/c1.18831738
81MP0002638_abnormal_pupillary_reflex1.18545761
82MP0005365_abnormal_bile_salt1.18296965
83MP0002090_abnormal_vision1.17703852
84MP0005084_abnormal_gallbladder_morpholo1.16288123
85MP0005174_abnormal_tail_pigmentation1.15787505
86MP0001756_abnormal_urination1.14779937
87MP0001986_abnormal_taste_sensitivity1.14697642
88MP0002882_abnormal_neuron_morphology1.14590827
89MP0009780_abnormal_chondrocyte_physiolo1.14537415
90MP0002139_abnormal_hepatobiliary_system1.12549511
91MP0005645_abnormal_hypothalamus_physiol1.11215027
92MP0004142_abnormal_muscle_tone1.10952269
93MP0005332_abnormal_amino_acid1.10947153
94MP0000427_abnormal_hair_cycle1.10557516
95MP0004215_abnormal_myocardial_fiber1.09860615
96MP0000778_abnormal_nervous_system1.09488294
97MP0003186_abnormal_redox_activity1.07192995
98MP0003633_abnormal_nervous_system1.06261390
99MP0000955_abnormal_spinal_cord1.06083669
100MP0004811_abnormal_neuron_physiology1.04799348
101MP0004019_abnormal_vitamin_homeostasis1.03453615
102MP0003806_abnormal_nucleotide_metabolis1.01522364
103MP0010678_abnormal_skin_adnexa1.01447256
104MP0005377_hearing/vestibular/ear_phenot1.01036870
105MP0003878_abnormal_ear_physiology1.01036870
106MP0005646_abnormal_pituitary_gland1.00657360
107MP0002557_abnormal_social/conspecific_i0.99981399
108MP0005167_abnormal_blood-brain_barrier0.98872583
109MP0000015_abnormal_ear_pigmentation0.98111143
110MP0003172_abnormal_lysosome_physiology0.97853809
111MP0001177_atelectasis0.97770127
112MP0004510_myositis0.97449577
113MP0002132_abnormal_respiratory_system0.97101541
114MP0003631_nervous_system_phenotype0.96755260
115MP0000681_abnormal_thyroid_gland0.93867183
116MP0005408_hypopigmentation0.93305047
117MP0005535_abnormal_body_temperature0.92526909
118MP0004145_abnormal_muscle_electrophysio0.92303723
119MP0009643_abnormal_urine_homeostasis0.91284212
120MP0001485_abnormal_pinna_reflex0.90175563
121MP0001963_abnormal_hearing_physiology0.89346691
122MP0003718_maternal_effect0.88748797
123MP0000465_gastrointestinal_hemorrhage0.87449607
124MP0002095_abnormal_skin_pigmentation0.87164970
125MP0008789_abnormal_olfactory_epithelium0.84978735
126MP0005389_reproductive_system_phenotype0.84071160
127MP0008004_abnormal_stomach_pH0.84042538
128MP0005671_abnormal_response_to0.83229762
129MP0001542_abnormal_bone_strength0.83129299
130MP0003866_abnormal_defecation0.82776324
131MP0004484_altered_response_of0.81417076
132MP0000230_abnormal_systemic_arterial0.81316143
133MP0005410_abnormal_fertilization0.81051843
134MP0002277_abnormal_respiratory_mucosa0.80954106
135MP0002138_abnormal_hepatobiliary_system0.80565199
136MP0005395_other_phenotype0.79861105
137MP0004085_abnormal_heartbeat0.79178177
138MP0003045_fibrosis0.78317778
139MP0008995_early_reproductive_senescence0.78103981
140MP0002118_abnormal_lipid_homeostasis0.76918509
141MP0003632_abnormal_nervous_system0.76673951
142MP0002972_abnormal_cardiac_muscle0.76551643
143MP0006082_CNS_inflammation0.76522301
144MP0003638_abnormal_response/metabolism_0.76357789
145MP0003137_abnormal_impulse_conducting0.76280809
146MP0002009_preneoplasia0.75686119
147MP0001188_hyperpigmentation0.75219062
148MP0003646_muscle_fatigue0.74933857
149MP0009764_decreased_sensitivity_to0.74050186
150MP0001664_abnormal_digestion0.72809324
151MP0003950_abnormal_plasma_membrane0.72047900
152MP0000747_muscle_weakness0.71920909
153MP0006138_congestive_heart_failure0.70410128
154MP0005379_endocrine/exocrine_gland_phen0.70291353
155MP0006072_abnormal_retinal_apoptosis0.69654417
156MP0002752_abnormal_somatic_nervous0.69018113
157MP0002069_abnormal_eating/drinking_beha0.65754769
158MP0002133_abnormal_respiratory_system0.65731827

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.17157920
2Myokymia (HP:0002411)3.97782825
3Visual hallucinations (HP:0002367)3.85515138
4Pheochromocytoma (HP:0002666)3.72109110
5Atonic seizures (HP:0010819)3.69118673
6Neurofibrillary tangles (HP:0002185)3.60599339
7Congenital stationary night blindness (HP:0007642)3.53648378
8Neuroendocrine neoplasm (HP:0100634)3.51062342
9Pancreatic cysts (HP:0001737)3.47086920
10Mutism (HP:0002300)3.42484972
11Absent/shortened dynein arms (HP:0200106)3.38508381
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.38508381
13Supranuclear gaze palsy (HP:0000605)3.34656110
14Epileptic encephalopathy (HP:0200134)3.33352227
15Cerebral hypomyelination (HP:0006808)3.32737596
16Nephronophthisis (HP:0000090)3.25803179
17Focal seizures (HP:0007359)3.20301426
18True hermaphroditism (HP:0010459)3.16884693
19Ventricular fibrillation (HP:0001663)3.15657123
20Gout (HP:0001997)3.14034423
21Abnormal respiratory motile cilium physiology (HP:0012261)3.11884512
22Segmental peripheral demyelination/remyelination (HP:0003481)3.09285970
23Abnormal ciliary motility (HP:0012262)3.06463706
24Progressive cerebellar ataxia (HP:0002073)3.03573287
25Rhinitis (HP:0012384)3.03474428
26Molar tooth sign on MRI (HP:0002419)3.03306852
27Abnormality of midbrain morphology (HP:0002418)3.03306852
28Abnormal respiratory motile cilium morphology (HP:0005938)2.97671324
29Abnormal respiratory epithelium morphology (HP:0012253)2.97671324
30Absence seizures (HP:0002121)2.96609844
31Dialeptic seizures (HP:0011146)2.95951309
32Polyphagia (HP:0002591)2.91204272
33Renal cortical cysts (HP:0000803)2.82972482
34Delusions (HP:0000746)2.82387567
35Abnormality of the renal cortex (HP:0011035)2.82286372
36Abnormality of the renal medulla (HP:0100957)2.79796944
37Cerebral inclusion bodies (HP:0100314)2.74567047
38Abnormal eating behavior (HP:0100738)2.59635322
39Febrile seizures (HP:0002373)2.58651269
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.56746240
41Hypoplasia of the fovea (HP:0007750)2.56746240
42Tubulointerstitial nephritis (HP:0001970)2.56516267
43Abnormality of the fovea (HP:0000493)2.54953856
44Abnormality of glycolipid metabolism (HP:0010969)2.50630418
45Abnormality of liposaccharide metabolism (HP:0010968)2.50630418
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.50630418
47Glycosuria (HP:0003076)2.47795592
48Abnormality of urine glucose concentration (HP:0011016)2.47795592
49Dysautonomia (HP:0002459)2.44583545
50Ankle clonus (HP:0011448)2.44562427
51Abnormal biliary tract physiology (HP:0012439)2.40725936
52Bile duct proliferation (HP:0001408)2.40725936
53Generalized tonic-clonic seizures (HP:0002069)2.40555342
54Bundle branch block (HP:0011710)2.38319336
55Gait imbalance (HP:0002141)2.34967672
56Action tremor (HP:0002345)2.34573360
57Split foot (HP:0001839)2.33088199
58Decreased circulating renin level (HP:0003351)2.33036609
59Abnormal drinking behavior (HP:0030082)2.28911479
60Polydipsia (HP:0001959)2.28911479
61Acute necrotizing encephalopathy (HP:0006965)2.25875356
62Hepatic necrosis (HP:0002605)2.25833635
63Increased circulating renin level (HP:0000848)2.24871593
64Medial flaring of the eyebrow (HP:0010747)2.24754485
65Progressive inability to walk (HP:0002505)2.24505800
66Truncal ataxia (HP:0002078)2.24375016
67CNS hypomyelination (HP:0003429)2.22543201
68Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.21659326
69Attenuation of retinal blood vessels (HP:0007843)2.16481038
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.15963927
71Congenital sensorineural hearing impairment (HP:0008527)2.15770436
72Increased cerebral lipofuscin (HP:0011813)2.15013197
73Metaphyseal dysplasia (HP:0100255)2.14864714
74Abnormality of glycolysis (HP:0004366)2.14251538
75Increased serum pyruvate (HP:0003542)2.14251538
76Hypothermia (HP:0002045)2.13200228
77Abnormal rod and cone electroretinograms (HP:0008323)2.11235068
78Congenital primary aphakia (HP:0007707)2.10328871
79Unsteady gait (HP:0002317)2.09134731
80Gaze-evoked nystagmus (HP:0000640)2.08024636
81Abnormal mitochondria in muscle tissue (HP:0008316)2.07624243
82Syncope (HP:0001279)2.06967022
83Diplopia (HP:0000651)2.06371219
84Abnormality of binocular vision (HP:0011514)2.06371219
85Amyotrophic lateral sclerosis (HP:0007354)2.05143844
86Cystic liver disease (HP:0006706)2.04901054
87Dysmetria (HP:0001310)2.04101146
88Bronchiectasis (HP:0002110)2.02524740
89Cerebral hemorrhage (HP:0001342)2.02121678
90Chronic bronchitis (HP:0004469)2.01385761
91Retinal dysplasia (HP:0007973)2.01254460
92Acute encephalopathy (HP:0006846)2.00371201
93Abnormality of renin-angiotensin system (HP:0000847)2.00194418
94Abolished electroretinogram (ERG) (HP:0000550)2.00023596
95Ketoacidosis (HP:0001993)1.99650038
96Interstitial pulmonary disease (HP:0006530)1.99271605
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98479779
98Nephrogenic diabetes insipidus (HP:0009806)1.98404555
99Decreased central vision (HP:0007663)1.97629168
100Large for gestational age (HP:0001520)1.96020291
101Abnormality of macular pigmentation (HP:0008002)1.94830056
102Peripheral hypomyelination (HP:0007182)1.94041655
103Renal Fanconi syndrome (HP:0001994)1.94013185
104Severe combined immunodeficiency (HP:0004430)1.92805424
105Progressive macrocephaly (HP:0004481)1.92707237
106Aplasia/Hypoplasia of the tibia (HP:0005772)1.92289700
107Methylmalonic acidemia (HP:0002912)1.92004768
108Abnormal autonomic nervous system physiology (HP:0012332)1.90964997
109Pancreatic fibrosis (HP:0100732)1.90574711
110Inability to walk (HP:0002540)1.89730947
111Mitochondrial inheritance (HP:0001427)1.89375375
112Spastic gait (HP:0002064)1.89224037
113Tubular atrophy (HP:0000092)1.88240672
114Congenital hepatic fibrosis (HP:0002612)1.88018691
115Epileptiform EEG discharges (HP:0011182)1.87811421
116Progressive visual loss (HP:0000529)1.86986799
117Chronic hepatic failure (HP:0100626)1.86708944
118Stomatitis (HP:0010280)1.86582451
119Postnatal microcephaly (HP:0005484)1.86518817
120Genital tract atresia (HP:0001827)1.86192216
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.86098699
122Abnormality of vitamin B metabolism (HP:0004340)1.85333042
123Abnormal hair whorl (HP:0010721)1.84918104
124Adactyly (HP:0009776)1.84799890
125Tetraplegia (HP:0002445)1.83855575
126Anxiety (HP:0000739)1.83616285
127Lipid accumulation in hepatocytes (HP:0006561)1.83146667
1283-Methylglutaconic aciduria (HP:0003535)1.82995071
129Type II lissencephaly (HP:0007260)1.82904014
130Elevated erythrocyte sedimentation rate (HP:0003565)1.81480796
131Hyperventilation (HP:0002883)1.81183434
132Ketosis (HP:0001946)1.81015395
133Vaginal atresia (HP:0000148)1.80915553
134Increased hepatocellular lipid droplets (HP:0006565)1.80640807
135Abnormality of the corticospinal tract (HP:0002492)1.79736226
136Median cleft lip (HP:0000161)1.79035616
137EEG with generalized epileptiform discharges (HP:0011198)1.78916244
138Degeneration of the lateral corticospinal tracts (HP:0002314)1.78294517
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78294517
140Thyroid-stimulating hormone excess (HP:0002925)1.77686901
141Short tibia (HP:0005736)1.77499785
142Oligomenorrhea (HP:0000876)1.77429849
143Dysostosis multiplex (HP:0000943)1.76929511
144Thyroiditis (HP:0100646)1.76662290
145Hemiparesis (HP:0001269)1.75548774
146Termporal pattern (HP:0011008)1.75365423
147Insidious onset (HP:0003587)1.75365423
148Abnormality of the vitamin B12 metabolism (HP:0004341)1.75179578
149Male pseudohermaphroditism (HP:0000037)1.73911254
150Hyperactive renin-angiotensin system (HP:0000841)1.73791908
151Hypokalemic alkalosis (HP:0001949)1.73453302
152Stomach cancer (HP:0012126)1.72544945
153Hyperalaninemia (HP:0003348)1.71780451
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71780451
155Abnormality of alanine metabolism (HP:0010916)1.71780451
156Esotropia (HP:0000565)1.71765895
157Progressive neurologic deterioration (HP:0002344)1.71414617
158Abnormality of macrophages (HP:0004311)1.69881641
159Muscle fiber splitting (HP:0003555)1.69771797
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68308133
161Optic disc pallor (HP:0000543)1.68304483
162Emotional lability (HP:0000712)1.68214722
163Tubulointerstitial abnormality (HP:0001969)1.67982338
164Limb dystonia (HP:0002451)1.67918486
165Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66877710
166IgG deficiency (HP:0004315)1.66390953
167Hypsarrhythmia (HP:0002521)1.65586122
168Polyuria (HP:0000103)1.65434152
169Excessive salivation (HP:0003781)1.64763833
170Drooling (HP:0002307)1.64763833
171Hepatocellular necrosis (HP:0001404)1.64313240
172Restlessness (HP:0000711)1.63884535
173Onion bulb formation (HP:0003383)1.63404870
174Poor speech (HP:0002465)1.62178948
175Megalencephaly (HP:0001355)1.62154399
176Fetal akinesia sequence (HP:0001989)1.61784883
177Akinesia (HP:0002304)1.61412287
178Increased CSF lactate (HP:0002490)1.60956012
179Neoplasm of the peripheral nervous system (HP:0100007)1.60433166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.86934191
2TAOK33.63151141
3RIPK43.32397394
4AKT33.18412683
5MAP3K93.11843317
6MAP4K23.06338393
7ARAF2.79502016
8TXK2.65063059
9ACVR1B2.57988524
10MAP3K122.47914451
11NTRK32.23552052
12BUB12.15732116
13MUSK2.11921648
14NUAK12.03958877
15GRK52.00918379
16STK391.99068292
17EPHA41.98469744
18MINK11.92221874
19MAP3K21.87620774
20MARK11.86980629
21CAMKK21.85812879
22CASK1.83968445
23OXSR11.80419411
24NTRK11.76268354
25GRK11.72724999
26PLK21.69564730
27MAP2K71.60477485
28KSR21.58430312
29ERBB31.57318640
30PDK41.57110221
31PDK31.57110221
32ADRBK21.56976030
33CCNB11.51554480
34BCKDK1.47603409
35NME11.43218925
36MAPK151.38047385
37MAP3K41.36807009
38TSSK61.36566167
39PDK21.34973992
40BCR1.34333018
41GRK61.30554147
42TNK21.29426179
43BMPR21.27891197
44BRAF1.27290947
45PINK11.27142900
46CDK191.23843311
47WNK41.20808684
48TNIK1.18139773
49DAPK21.16303743
50PAK61.15848312
51KIT1.15472248
52PNCK1.15035100
53PRKCG1.11641580
54GRK71.09359461
55TLK11.09349336
56PRKCE1.08781955
57INSRR1.08600861
58LIMK11.08443934
59BRSK11.05094636
60CDK51.04266404
61EIF2AK31.02954949
62TRIM280.99442777
63SGK4940.98702171
64SGK2230.98702171
65STK240.97868605
66LMTK20.95867316
67MAP2K20.95408064
68PRPF4B0.94664713
69PIK3CA0.94582545
70PLK30.93434467
71TEC0.92984975
72PRKD30.92883404
73NTRK20.91248304
74EPHB10.89880626
75MARK30.87893333
76NLK0.86930251
77BLK0.86591759
78CSNK1G20.85821351
79PHKG10.85324655
80PHKG20.85324655
81BRSK20.84121578
82MYLK0.83579082
83MAPKAPK30.83189063
84CAMKK10.82537077
85CAMK2B0.81455566
86CAMK2A0.80210861
87CAMK2D0.79257984
88PDPK10.73657073
89TIE10.73150023
90FGR0.72742703
91NEK60.71943502
92PRKCQ0.71345232
93IRAK30.71314316
94IRAK20.70890711
95CDK140.70340329
96BMPR1B0.69490713
97JAK10.69477841
98PAK30.69005922
99ITK0.68900540
100CDK30.67812442
101IKBKE0.64662023
102MAP2K40.64596953
103MAPKAPK50.63164257
104WNK30.62645985
105MAP3K130.62307376
106MAPK130.61723098
107OBSCN0.60634976
108STK160.57943727
109CDK180.57519299
110SYK0.57445158
111ZAK0.57298538
112IKBKB0.57008101
113FES0.56454017
114CSNK1G30.56301974
115MST40.56233399
116CAMK2G0.56171674
117STK38L0.55337674
118CSNK1G10.54376126
119ZAP700.54306936
120ADRBK10.53602280
121IRAK40.53409189
122IGF1R0.52790463
123CDK150.52367304
124PTK2B0.50881035
125KSR10.50493030
126MAP2K10.50065257
127EPHA30.49911330
128DAPK10.49355006
129MAPK70.49273051
130TYK20.48584774
131UHMK10.48540033
132DYRK1A0.48267385
133PRKAA20.47510721
134MST1R0.46101003
135LYN0.45220824
136CSNK1A1L0.44798637
137FER0.43816551
138SIK30.43659286
139CSNK1A10.43414113
140PDK10.43395665
141WNK10.43353698
142EIF2AK10.42928745
143ABL10.42711289
144RAF10.42689585
145MAP3K10.42502532
146LCK0.41204719
147MAP3K70.40737103
148PRKACA0.40736981
149SGK20.40539467
150JAK30.40508027
151CDK11A0.40424920
152IRAK10.39311649
153MAP2K60.38787172

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.18858061
2Synaptic vesicle cycle_Homo sapiens_hsa047213.15815448
3Collecting duct acid secretion_Homo sapiens_hsa049663.12932557
4Nicotine addiction_Homo sapiens_hsa050332.63878716
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41014428
6Oxidative phosphorylation_Homo sapiens_hsa001902.30485112
7Regulation of autophagy_Homo sapiens_hsa041402.26240341
8Linoleic acid metabolism_Homo sapiens_hsa005912.26019251
9Vibrio cholerae infection_Homo sapiens_hsa051102.16746912
10Butanoate metabolism_Homo sapiens_hsa006502.14897866
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10812073
12Propanoate metabolism_Homo sapiens_hsa006402.09063498
13Nitrogen metabolism_Homo sapiens_hsa009102.01439922
14GABAergic synapse_Homo sapiens_hsa047272.00732267
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93901592
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81846389
17Morphine addiction_Homo sapiens_hsa050321.79901503
18Circadian entrainment_Homo sapiens_hsa047131.78027079
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76693963
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75748176
21Caffeine metabolism_Homo sapiens_hsa002321.72122530
22Lysosome_Homo sapiens_hsa041421.68456539
23Chemical carcinogenesis_Homo sapiens_hsa052041.67831771
24Asthma_Homo sapiens_hsa053101.67095879
25Long-term potentiation_Homo sapiens_hsa047201.65557886
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65355885
27Glutamatergic synapse_Homo sapiens_hsa047241.61735664
28Parkinsons disease_Homo sapiens_hsa050121.57094441
29Olfactory transduction_Homo sapiens_hsa047401.56502082
30Taste transduction_Homo sapiens_hsa047421.55794952
31Salivary secretion_Homo sapiens_hsa049701.54634985
32Amphetamine addiction_Homo sapiens_hsa050311.54533086
33Rheumatoid arthritis_Homo sapiens_hsa053231.52097812
34Peroxisome_Homo sapiens_hsa041461.52086692
35Alzheimers disease_Homo sapiens_hsa050101.48223656
36Insulin secretion_Homo sapiens_hsa049111.48150073
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.47781466
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.46657470
39Tryptophan metabolism_Homo sapiens_hsa003801.46270800
40Serotonergic synapse_Homo sapiens_hsa047261.46146957
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43790919
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.42659148
43Mineral absorption_Homo sapiens_hsa049781.41821668
44Dopaminergic synapse_Homo sapiens_hsa047281.41425373
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40328022
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39189544
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.39064432
48Protein export_Homo sapiens_hsa030601.35651135
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.35432459
50Cardiac muscle contraction_Homo sapiens_hsa042601.33468045
51Arachidonic acid metabolism_Homo sapiens_hsa005901.30646760
52Sphingolipid metabolism_Homo sapiens_hsa006001.29259962
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26286405
54Phagosome_Homo sapiens_hsa041451.25768707
55Retinol metabolism_Homo sapiens_hsa008301.24529237
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20315771
57Allograft rejection_Homo sapiens_hsa053301.18692719
58Gastric acid secretion_Homo sapiens_hsa049711.16196594
59Graft-versus-host disease_Homo sapiens_hsa053321.16076573
60Huntingtons disease_Homo sapiens_hsa050161.15549365
61Renin secretion_Homo sapiens_hsa049241.10274039
62RNA polymerase_Homo sapiens_hsa030201.09368624
63Cholinergic synapse_Homo sapiens_hsa047251.08953810
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08521456
65Histidine metabolism_Homo sapiens_hsa003401.07629309
66Long-term depression_Homo sapiens_hsa047301.07402060
67Proteasome_Homo sapiens_hsa030501.06400397
68Fatty acid degradation_Homo sapiens_hsa000711.05930587
69Primary immunodeficiency_Homo sapiens_hsa053401.05388433
70Steroid hormone biosynthesis_Homo sapiens_hsa001401.04933752
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04468814
72Fatty acid elongation_Homo sapiens_hsa000621.04152556
73beta-Alanine metabolism_Homo sapiens_hsa004101.03190441
74Cocaine addiction_Homo sapiens_hsa050301.01565424
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98492312
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98459288
77Circadian rhythm_Homo sapiens_hsa047100.98274371
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98109355
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97155001
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.96825174
81Calcium signaling pathway_Homo sapiens_hsa040200.96707515
82ABC transporters_Homo sapiens_hsa020100.95783208
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92146099
84Ether lipid metabolism_Homo sapiens_hsa005650.92086527
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91791120
86Oocyte meiosis_Homo sapiens_hsa041140.87864134
87Basal transcription factors_Homo sapiens_hsa030220.87085625
88Oxytocin signaling pathway_Homo sapiens_hsa049210.86359084
89Fat digestion and absorption_Homo sapiens_hsa049750.78664368
90Fatty acid metabolism_Homo sapiens_hsa012120.78142880
91RNA degradation_Homo sapiens_hsa030180.77692299
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77294729
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74914790
94GnRH signaling pathway_Homo sapiens_hsa049120.70667204
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70367711
96Phototransduction_Homo sapiens_hsa047440.70241406
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.69274607
98Gap junction_Homo sapiens_hsa045400.67484459
99Pancreatic secretion_Homo sapiens_hsa049720.66473895
100Staphylococcus aureus infection_Homo sapiens_hsa051500.66301072
101cAMP signaling pathway_Homo sapiens_hsa040240.65151511
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65139412
103Thyroid hormone synthesis_Homo sapiens_hsa049180.64637119
104Glycerolipid metabolism_Homo sapiens_hsa005610.63211447
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63089148
106Antigen processing and presentation_Homo sapiens_hsa046120.62433850
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.61913923
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61710389
109Type I diabetes mellitus_Homo sapiens_hsa049400.61277416
110Tyrosine metabolism_Homo sapiens_hsa003500.59803034
111Endocytosis_Homo sapiens_hsa041440.58750778
112PPAR signaling pathway_Homo sapiens_hsa033200.58001316
113Ovarian steroidogenesis_Homo sapiens_hsa049130.57678967
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57507969
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57479483
116Inositol phosphate metabolism_Homo sapiens_hsa005620.57358434
117Dorso-ventral axis formation_Homo sapiens_hsa043200.56012843
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55712343
119Estrogen signaling pathway_Homo sapiens_hsa049150.54407068
120Steroid biosynthesis_Homo sapiens_hsa001000.54008619
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53726979
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52618108
123Glutathione metabolism_Homo sapiens_hsa004800.50306640
124Hematopoietic cell lineage_Homo sapiens_hsa046400.50200829
125Metabolic pathways_Homo sapiens_hsa011000.50130619
126Tuberculosis_Homo sapiens_hsa051520.49832507
127Renal cell carcinoma_Homo sapiens_hsa052110.49679413
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48467946
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48131713
130Type II diabetes mellitus_Homo sapiens_hsa049300.48038981
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47118544
132Axon guidance_Homo sapiens_hsa043600.46743919
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44420743
134Sulfur metabolism_Homo sapiens_hsa009200.44012786
135Autoimmune thyroid disease_Homo sapiens_hsa053200.41745753
136Renin-angiotensin system_Homo sapiens_hsa046140.41262093
137Vitamin digestion and absorption_Homo sapiens_hsa049770.41155594
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41113427
139Fructose and mannose metabolism_Homo sapiens_hsa000510.39272007
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38860864
141Pentose phosphate pathway_Homo sapiens_hsa000300.38640246
142Purine metabolism_Homo sapiens_hsa002300.37938410
143Dilated cardiomyopathy_Homo sapiens_hsa054140.35486313
144ErbB signaling pathway_Homo sapiens_hsa040120.33920071
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32210553
146Prion diseases_Homo sapiens_hsa050200.31748778
147MAPK signaling pathway_Homo sapiens_hsa040100.30322792
148Choline metabolism in cancer_Homo sapiens_hsa052310.29614015
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.28363248
150Salmonella infection_Homo sapiens_hsa051320.28187307

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