TMEM51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)5.30386134
2regulation of mononuclear cell migration (GO:0071675)5.20579136
3oligosaccharide catabolic process (GO:0009313)5.10715249
4glycolipid catabolic process (GO:0019377)4.98140615
5negative regulation of interleukin-12 production (GO:0032695)4.69251462
6response to peptidoglycan (GO:0032494)4.60280985
7regulation of vitamin D biosynthetic process (GO:0060556)4.51166929
8ceramide catabolic process (GO:0046514)4.34309664
9cellular response to thyroid hormone stimulus (GO:0097067)4.33600287
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.32051553
11L-phenylalanine metabolic process (GO:0006558)4.32051553
12sulfur amino acid catabolic process (GO:0000098)4.28162126
13negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.26839655
14membrane lipid catabolic process (GO:0046466)4.26591960
15regulation of cytokine secretion involved in immune response (GO:0002739)4.24144921
16positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.21342234
17regulation of podosome assembly (GO:0071801)4.18962723
18positive regulation of chemokine biosynthetic process (GO:0045080)4.15139714
19amino sugar catabolic process (GO:0046348)4.06949811
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.05101887
21L-phenylalanine catabolic process (GO:0006559)4.05101887
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.04016394
23T-helper 1 type immune response (GO:0042088)4.02732258
24glyoxylate metabolic process (GO:0046487)4.02120656
25sphingolipid catabolic process (GO:0030149)4.00881850
26lysine metabolic process (GO:0006553)4.00475578
27lysine catabolic process (GO:0006554)4.00475578
28adhesion of symbiont to host cell (GO:0044650)3.89997141
29virion attachment to host cell (GO:0019062)3.89997141
30regulation of membrane protein ectodomain proteolysis (GO:0051043)3.84776889
31regulation of vitamin metabolic process (GO:0030656)3.83401896
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.79271416
33regulation of cholesterol homeostasis (GO:2000188)3.75753521
34regulation of macrophage chemotaxis (GO:0010758)3.70225610
35monocyte chemotaxis (GO:0002548)3.69258005
36Golgi transport vesicle coating (GO:0048200)3.69249417
37COPI coating of Golgi vesicle (GO:0048205)3.69249417
38regulation of chemokine biosynthetic process (GO:0045073)3.67334075
39tyrosine metabolic process (GO:0006570)3.63298325
40barbed-end actin filament capping (GO:0051016)3.63258824
41response to thyroid hormone (GO:0097066)3.55939140
42NIK/NF-kappaB signaling (GO:0038061)3.53097667
43adhesion of symbiont to host (GO:0044406)3.52963100
44myeloid dendritic cell differentiation (GO:0043011)3.51516493
45cysteine metabolic process (GO:0006534)3.51296117
46positive regulation of heat generation (GO:0031652)3.51189186
47aromatic amino acid family catabolic process (GO:0009074)3.50886436
48branching involved in labyrinthine layer morphogenesis (GO:0060670)3.48497147
49neutrophil activation involved in immune response (GO:0002283)3.47415172
50negative regulation of nitric oxide biosynthetic process (GO:0045019)3.45544398
51bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44992090
52reverse cholesterol transport (GO:0043691)3.44162857
53drug transmembrane transport (GO:0006855)3.43610031
54regulation of fever generation (GO:0031620)3.43170791
55macrophage activation involved in immune response (GO:0002281)3.42779275
56regulation of cholesterol storage (GO:0010885)3.39328554
574-hydroxyproline metabolic process (GO:0019471)3.38974084
58N-acetylneuraminate metabolic process (GO:0006054)3.38498355
59peptidyl-glutamic acid carboxylation (GO:0017187)3.37120386
60protein carboxylation (GO:0018214)3.37120386
61urate metabolic process (GO:0046415)3.36703484
62protein localization to endosome (GO:0036010)3.33361478
63cellular response to arsenic-containing substance (GO:0071243)3.30417256
64positive regulation of leukocyte degranulation (GO:0043302)3.29995679
65immunoglobulin mediated immune response (GO:0016064)3.28615595
66complement activation, alternative pathway (GO:0006957)3.25979913
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.25877836
68proline metabolic process (GO:0006560)3.25275535
69amino-acid betaine metabolic process (GO:0006577)3.23437637
70kynurenine metabolic process (GO:0070189)3.22090315
71positive regulation of monocyte chemotaxis (GO:0090026)3.22039543
72regulation of cholesterol esterification (GO:0010872)3.21317051
73regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.20804658
74tricarboxylic acid metabolic process (GO:0072350)3.20421158
75homocysteine metabolic process (GO:0050667)3.20054712
76peptide catabolic process (GO:0043171)3.19951193
77cellular modified amino acid catabolic process (GO:0042219)3.19532738
78proline biosynthetic process (GO:0006561)3.19081153
79primary alcohol catabolic process (GO:0034310)3.18808394
80intestinal absorption (GO:0050892)3.17595925
81high-density lipoprotein particle remodeling (GO:0034375)3.17067483
82negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.16208541
83intestinal cholesterol absorption (GO:0030299)3.15425011
84phospholipid efflux (GO:0033700)3.14457857
85alpha-linolenic acid metabolic process (GO:0036109)3.14427247
86aromatic amino acid family metabolic process (GO:0009072)3.13800297
87negative regulation of cytokine production involved in immune response (GO:0002719)3.12857338
88tryptophan metabolic process (GO:0006568)3.12491127
89serine family amino acid catabolic process (GO:0009071)3.10985287
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.10907733
91growth hormone receptor signaling pathway (GO:0060396)3.10394890
92low-density lipoprotein particle clearance (GO:0034383)3.10077273
93valine metabolic process (GO:0006573)3.06201003
94indole-containing compound catabolic process (GO:0042436)3.05410681
95indolalkylamine catabolic process (GO:0046218)3.05410681
96tryptophan catabolic process (GO:0006569)3.05410681
97short-chain fatty acid metabolic process (GO:0046459)3.03429171
98hemidesmosome assembly (GO:0031581)3.03246697
99negative regulation of myeloid cell apoptotic process (GO:0033033)3.01884919
100pinocytosis (GO:0006907)3.00383350
101regulation of protein activation cascade (GO:2000257)2.99312677
102decidualization (GO:0046697)2.99269276
103lipoprotein metabolic process (GO:0042157)2.98371499
104protein retention in ER lumen (GO:0006621)2.97676500
105regulation of apoptotic cell clearance (GO:2000425)2.97479933
106hormone catabolic process (GO:0042447)2.97017999
107regulation of complement activation (GO:0030449)2.94931348
108fatty acid beta-oxidation (GO:0006635)2.94628340
109carnitine metabolic process (GO:0009437)2.93186860
110transcytosis (GO:0045056)2.92462818
111adenosine receptor signaling pathway (GO:0001973)2.91691225
112negative regulation of sterol transport (GO:0032372)2.91563728
113negative regulation of cholesterol transport (GO:0032375)2.91563728
114drug transport (GO:0015893)2.90824524
115regulation of chronic inflammatory response (GO:0002676)2.90484706
116lipid oxidation (GO:0034440)2.89613232
117positive regulation of fatty acid biosynthetic process (GO:0045723)2.89195273
118plasma lipoprotein particle assembly (GO:0034377)2.88897341
119regulation of T-helper 1 cell differentiation (GO:0045625)2.88385868
120plasma lipoprotein particle clearance (GO:0034381)2.88294451
121myeloid dendritic cell activation (GO:0001773)2.87688155
122regulation of superoxide anion generation (GO:0032928)2.87390418
123fatty acid oxidation (GO:0019395)2.86041043
124urea cycle (GO:0000050)2.85986140
125urea metabolic process (GO:0019627)2.85986140
126dendritic cell differentiation (GO:0097028)2.85758311
127protein-lipid complex remodeling (GO:0034368)2.84565049
128macromolecular complex remodeling (GO:0034367)2.84565049
129plasma lipoprotein particle remodeling (GO:0034369)2.84565049
130fat-soluble vitamin biosynthetic process (GO:0042362)2.83603211
1312-oxoglutarate metabolic process (GO:0006103)2.80584442
132eosinophil chemotaxis (GO:0048245)2.79908876
133regulation of mast cell degranulation (GO:0043304)2.79061161
134apoptotic cell clearance (GO:0043277)2.78723806
135flavonoid metabolic process (GO:0009812)2.78300515
136triglyceride homeostasis (GO:0070328)2.78257393
137acylglycerol homeostasis (GO:0055090)2.78257393
138regulation of monocyte chemotaxis (GO:0090025)2.77308906
139L-alpha-amino acid transmembrane transport (GO:1902475)2.76937767
140aspartate family amino acid catabolic process (GO:0009068)2.76619537
141ethanol metabolic process (GO:0006067)2.75872573
142sphingosine metabolic process (GO:0006670)2.75582316
143cellular response to lipopolysaccharide (GO:0071222)2.75573490
144negative regulation of lipid storage (GO:0010888)2.75059678
145regulation of early endosome to late endosome transport (GO:2000641)2.73504836
146regulation of interferon-alpha production (GO:0032647)2.73008406
147regulation of triglyceride catabolic process (GO:0010896)2.72338244
148positive regulation of NF-kappaB import into nucleus (GO:0042346)2.71889183
149response to growth hormone (GO:0060416)2.70152761
150regulation of nitric oxide biosynthetic process (GO:0045428)2.70010567
151regulation of leukocyte degranulation (GO:0043300)2.69896385
152positive regulation of triglyceride metabolic process (GO:0090208)2.69693765
153melanin biosynthetic process (GO:0042438)2.68760379
154positive regulation by symbiont of host defense response (GO:0052509)2.68652006
155modulation by symbiont of host defense response (GO:0052031)2.68652006
156modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68652006
157modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68652006
158positive regulation by organism of defense response of other organism involved in symbiotic interact2.68652006
159modulation by symbiont of host immune response (GO:0052553)2.68652006
160renal absorption (GO:0070293)2.68621538
161glial cell migration (GO:0008347)2.67548804
162positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.66697177
163ketone body metabolic process (GO:1902224)2.66436349
164positive regulation of interleukin-6 production (GO:0032755)2.66264682
165ethanol oxidation (GO:0006069)2.66208977
166regulation of inflammatory response to antigenic stimulus (GO:0002861)2.65298978
167drug catabolic process (GO:0042737)2.65070861
168response to mercury ion (GO:0046689)2.64652885
169gap junction assembly (GO:0016264)2.64586295
170interferon-gamma-mediated signaling pathway (GO:0060333)2.64243420
171protein-lipid complex assembly (GO:0065005)2.64088754
172nitrogen cycle metabolic process (GO:0071941)2.64017067
173regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63967954
174macrophage differentiation (GO:0030225)2.63751436
175negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.63324478
176positive regulation of extracellular matrix organization (GO:1903055)2.63280690
177positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.63149076
178positive regulation of antigen processing and presentation (GO:0002579)2.63114221
179sterol homeostasis (GO:0055092)2.62290677
180cholesterol homeostasis (GO:0042632)2.62147719
181cellular amino acid catabolic process (GO:0009063)2.61662388
182cellular response to growth hormone stimulus (GO:0071378)2.61176024
183cellular response to molecule of bacterial origin (GO:0071219)2.61020727
184antigen processing and presentation of endogenous antigen (GO:0019883)2.60788542
185alpha-amino acid catabolic process (GO:1901606)2.60394208
186cyclooxygenase pathway (GO:0019371)2.60374279
187glutamine family amino acid biosynthetic process (GO:0009084)2.59634901
188positive regulation of mast cell activation involved in immune response (GO:0033008)2.59050300
189positive regulation of mast cell degranulation (GO:0043306)2.59050300
190aldehyde catabolic process (GO:0046185)2.58279249
191response to protozoan (GO:0001562)2.57138818
192hyaluronan catabolic process (GO:0030214)2.56826728
193regulation of antigen processing and presentation (GO:0002577)2.56190750
194regulation of apoptotic process involved in morphogenesis (GO:1902337)2.55960419
195modulation by symbiont of host cellular process (GO:0044068)2.55630145
196diol metabolic process (GO:0034311)2.55172232
197response to acidic pH (GO:0010447)2.53213073
198positive regulation of lymphocyte apoptotic process (GO:0070230)2.51773025
199granulocyte activation (GO:0036230)2.51583013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.11084629
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.25159621
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.42649289
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.31083714
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.00780032
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.56033706
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.68284282
8CLOCK_20551151_ChIP-Seq_293T_Human2.55644935
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.38940908
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.29046467
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.27645265
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.27618233
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24275436
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17122784
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15691795
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.15239993
17SOX2_27498859_Chip-Seq_STOMACH_Mouse2.11565456
18* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.04256789
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02260482
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96422967
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.96253655
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94681559
23VDR_21846776_ChIP-Seq_THP-1_Human1.93638198
24VDR_24763502_ChIP-Seq_THP-1_Human1.91304644
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87181021
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86003390
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83889690
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81055785
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78416970
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77941784
31VDR_24787735_ChIP-Seq_THP-1_Human1.67859315
32* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67835222
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67753870
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66701907
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66649576
36GATA4_25053715_ChIP-Seq_YYC3_Human1.64366379
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64089470
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63038724
39LXR_22292898_ChIP-Seq_THP-1_Human1.62174149
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60968168
41SPI1_23127762_ChIP-Seq_K562_Human1.60486561
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58331929
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56234005
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56234005
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56234005
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55237601
47* RACK7_27058665_Chip-Seq_MCF-7_Human1.54988254
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.50715769
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.50327121
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47722583
51GATA1_22025678_ChIP-Seq_K562_Human1.46062589
52* GATA6_25053715_ChIP-Seq_YYC3_Human1.43151936
53* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43009288
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42687119
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41363084
56ZNF263_19887448_ChIP-Seq_K562_Human1.41291353
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40698353
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40284942
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39293243
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38333816
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36212699
62TFEB_21752829_ChIP-Seq_HELA_Human1.35506230
63* SOX2_20726797_ChIP-Seq_SW620_Human1.35148862
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34616741
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.33699061
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.33486082
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32120524
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29929974
69TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27905870
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26033806
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23680646
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22602069
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22507922
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21491701
75ATF3_27146783_Chip-Seq_COLON_Human1.21075338
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20332028
77* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20003867
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18602339
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.17849591
80SPI1_23547873_ChIP-Seq_NB4_Human1.15991690
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.15783620
82* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15755096
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15386643
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14497779
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14446573
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.13741963
87* KDM2B_26808549_Chip-Seq_K562_Human1.13677692
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12704671
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.10304248
90* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08862513
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08750779
92PU_27001747_Chip-Seq_BMDM_Mouse1.08268466
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06004511
94SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05900736
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04666304
96KDM2B_26808549_Chip-Seq_DND41_Human1.04313509
97TCF7_22412390_ChIP-Seq_EML_Mouse1.04039643
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03611269
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02150007
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01908783
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00995706
102* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00882364
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00757810
104STAT1_20625510_ChIP-Seq_HELA_Human1.00173452
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.00091788
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99346449
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98567277
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98170424
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98095660
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98067422
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.97566146
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97236549
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96974757
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95788375
115* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95388381
116* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95010790
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.94373953
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94344495
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94321429
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.93859675
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.92903684
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.92903684
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92667351
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92305961
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91275121
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90859424
127IRF8_27001747_Chip-Seq_BMDM_Mouse0.89310409
128NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87547556
129SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86654984
130* HNF4A_19822575_ChIP-Seq_HepG2_Human0.86631459
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85301174
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85294690
133SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84744088
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84744088
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83813937
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82720437
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82340702
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81559159
139EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81405174
140NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80997612
141* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80696492
142BCOR_27268052_Chip-Seq_Bcells_Human0.80642774
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80349752
144ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79897876
145IRF8_21731497_ChIP-ChIP_J774_Mouse0.79811842
146RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77896187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.50690751
2MP0002139_abnormal_hepatobiliary_system4.24179902
3MP0002138_abnormal_hepatobiliary_system3.78453688
4MP0006082_CNS_inflammation3.45395669
5MP0005365_abnormal_bile_salt3.25913398
6MP0005085_abnormal_gallbladder_physiolo3.21785444
7MP0002148_abnormal_hypersensitivity_rea3.06072427
8MP0009840_abnormal_foam_cell3.04785528
9MP0004510_myositis2.96314504
10MP0003806_abnormal_nucleotide_metabolis2.83929863
11MP0000343_altered_response_to2.54800114
12MP0002254_reproductive_system_inflammat2.53225931
13MP0009785_altered_susceptibility_to2.49954626
14MP0008875_abnormal_xenobiotic_pharmacok2.41496482
15MP0005058_abnormal_lysosome_morphology2.30973536
16MP0003705_abnormal_hypodermis_morpholog2.28144338
17MP0001666_abnormal_nutrient_absorption2.26772734
18MP0005332_abnormal_amino_acid2.25257835
19MP0010234_abnormal_vibrissa_follicle2.23777283
20MP0004019_abnormal_vitamin_homeostasis2.21800932
21MP0005083_abnormal_biliary_tract2.21644076
22MP0002419_abnormal_innate_immunity2.19518731
23MP0003252_abnormal_bile_duct2.18438084
24MP0003195_calcinosis2.16845746
25MP0009643_abnormal_urine_homeostasis2.10387167
26MP0004264_abnormal_extraembryonic_tissu2.10192009
27MP0005451_abnormal_body_composition2.09697765
28MP0010329_abnormal_lipoprotein_level2.08883820
29MP0008004_abnormal_stomach_pH2.04126002
30MP0003300_gastrointestinal_ulcer1.95235840
31MP0003724_increased_susceptibility_to1.94280928
32MP0005387_immune_system_phenotype1.90706044
33MP0001790_abnormal_immune_system1.90706044
34MP0002998_abnormal_bone_remodeling1.89488376
35MP0002877_abnormal_melanocyte_morpholog1.86279054
36MP0005025_abnormal_response_to1.85326518
37MP0005000_abnormal_immune_tolerance1.81290912
38MP0001533_abnormal_skeleton_physiology1.80676364
39MP0001756_abnormal_urination1.76938276
40MP0003566_abnormal_cell_adhesion1.69342255
41MP0003191_abnormal_cellular_cholesterol1.65551752
42MP0005671_abnormal_response_to1.64461813
43MP0000858_altered_metastatic_potential1.62045817
44MP0001835_abnormal_antigen_presentation1.61478250
45MP0003448_altered_tumor_morphology1.61017042
46MP0004043_abnormal_pH_regulation1.58019605
47MP0009278_abnormal_bone_marrow1.57361591
48MP0002452_abnormal_antigen_presenting1.53810506
49MP0000372_irregular_coat_pigmentation1.52464840
50MP0005408_hypopigmentation1.50157067
51MP0005310_abnormal_salivary_gland1.45740272
52MP0000685_abnormal_immune_system1.45563279
53MP0005257_abnormal_intraocular_pressure1.45308806
54MP0005166_decreased_susceptibility_to1.44083465
55MP0003690_abnormal_glial_cell1.42536647
56MP0003878_abnormal_ear_physiology1.41587527
57MP0005377_hearing/vestibular/ear_phenot1.41587527
58MP0005319_abnormal_enzyme/_coenzyme1.41426770
59MP0002723_abnormal_immune_serum1.38442619
60MP0004272_abnormal_basement_membrane1.36158178
61MP0000609_abnormal_liver_physiology1.35314122
62MP0002796_impaired_skin_barrier1.32283281
63MP0003183_abnormal_peptide_metabolism1.31586762
64MP0002136_abnormal_kidney_physiology1.26926888
65MP0002118_abnormal_lipid_homeostasis1.22500409
66MP0005084_abnormal_gallbladder_morpholo1.20089907
67MP0003186_abnormal_redox_activity1.18765807
68MP0002405_respiratory_system_inflammati1.15916033
69MP0003329_amyloid_beta_deposits1.12090591
70MP0009333_abnormal_splenocyte_physiolog1.10137018
71MP0005397_hematopoietic_system_phenotyp1.09963427
72MP0001545_abnormal_hematopoietic_system1.09963427
73MP0005464_abnormal_platelet_physiology1.08134328
74MP0001819_abnormal_immune_cell1.06199960
75MP0000920_abnormal_myelination1.06076899
76MP0003091_abnormal_cell_migration1.05378506
77MP0002420_abnormal_adaptive_immunity1.04039584
78MP0001800_abnormal_humoral_immune1.03286870
79MP0005164_abnormal_response_to1.01936587
80MP0000371_diluted_coat_color1.01401166
81MP0005636_abnormal_mineral_homeostasis1.00701779
82MP0005165_increased_susceptibility_to0.99377323
83MP0008961_abnormal_basal_metabolism0.98763967
84MP0008260_abnormal_autophagy0.98685652
85MP0003453_abnormal_keratinocyte_physiol0.98478775
86MP0010307_abnormal_tumor_latency0.96028315
87MP0000538_abnormal_urinary_bladder0.95485115
88MP0001765_abnormal_ion_homeostasis0.95291753
89MP0003303_peritoneal_inflammation0.94772188
90MP0005584_abnormal_enzyme/coenzyme_acti0.94708699
91MP0005220_abnormal_exocrine_pancreas0.92064754
92MP0004858_abnormal_nervous_system0.91746164
93MP0005023_abnormal_wound_healing0.91337843
94MP0000598_abnormal_liver_morphology0.89552176
95MP0010352_gastrointestinal_tract_polyps0.88765592
96MP0003634_abnormal_glial_cell0.88583034
97MP0001542_abnormal_bone_strength0.88468080
98MP0003075_altered_response_to0.88260812
99MP0005076_abnormal_cell_differentiation0.87064262
100MP0005670_abnormal_white_adipose0.86974105
101MP0003172_abnormal_lysosome_physiology0.86848000
102MP0003638_abnormal_response/metabolism_0.86810095
103MP0001849_ear_inflammation0.86024162
104MP0005595_abnormal_vascular_smooth0.85644813
105MP0005390_skeleton_phenotype0.85643544
106MP0009384_cardiac_valve_regurgitation0.82483043
107MP0002090_abnormal_vision0.80312561
108MP0008469_abnormal_protein_level0.78452454
109MP0003436_decreased_susceptibility_to0.78305292
110MP0002896_abnormal_bone_mineralization0.76423424
111MP0003795_abnormal_bone_structure0.76118997
112MP0002332_abnormal_exercise_endurance0.75769083
113MP0003656_abnormal_erythrocyte_physiolo0.75700886
114MP0005167_abnormal_blood-brain_barrier0.75458359
115MP0004947_skin_inflammation0.75339385
116MP0000604_amyloidosis0.74732476
117MP0010386_abnormal_urinary_bladder0.74443701
118MP0001873_stomach_inflammation0.73621794
119MP0003279_aneurysm0.73458106
120MP0002078_abnormal_glucose_homeostasis0.73258575
121MP0000490_abnormal_crypts_of0.72997608
122MP0001853_heart_inflammation0.72592671
123MP0009763_increased_sensitivity_to0.71357931
124MP0003941_abnormal_skin_development0.71231647
125MP0003828_pulmonary_edema0.70382224
126MP0002277_abnormal_respiratory_mucosa0.70243635
127MP0009764_decreased_sensitivity_to0.70164916
128MP0002928_abnormal_bile_duct0.69046129
129MP0005666_abnormal_adipose_tissue0.68720420
130MP0003950_abnormal_plasma_membrane0.68110888
131MP0002098_abnormal_vibrissa_morphology0.67362840
132MP0009642_abnormal_blood_homeostasis0.67078887
133MP0000462_abnormal_digestive_system0.66953428
134MP0003283_abnormal_digestive_organ0.66810489
135MP0004084_abnormal_cardiac_muscle0.65714746
136MP0010368_abnormal_lymphatic_system0.64848901
137MP0000716_abnormal_immune_system0.64569941
138MP0002089_abnormal_postnatal_growth/wei0.63627050
139MP0006054_spinal_hemorrhage0.63016183
140MP0001845_abnormal_inflammatory_respons0.62116772
141MP0002135_abnormal_kidney_morphology0.61747754
142MP0001944_abnormal_pancreas_morphology0.61710343
143MP0002972_abnormal_cardiac_muscle0.61640661
144MP0002909_abnormal_adrenal_gland0.61466204
145MP0004185_abnormal_adipocyte_glucose0.59798261
146MP0005248_abnormal_Harderian_gland0.59686987
147MP0001764_abnormal_homeostasis0.59595796
148MP0002127_abnormal_cardiovascular_syste0.58690521
149MP0001216_abnormal_epidermal_layer0.58374028
150MP0005501_abnormal_skin_physiology0.57680984
151MP0000249_abnormal_blood_vessel0.57185590
152MP0000230_abnormal_systemic_arterial0.56570192
153MP0002060_abnormal_skin_morphology0.56411191
154MP0001663_abnormal_digestive_system0.56240776
155MP0010155_abnormal_intestine_physiology0.56099201
156MP0005381_digestive/alimentary_phenotyp0.55955602

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)8.60875132
2Abnormality of liposaccharide metabolism (HP:0010968)8.60875132
3Abnormality of glycosphingolipid metabolism (HP:0004343)8.60875132
4Increased cerebral lipofuscin (HP:0011813)5.56111708
5Disinhibition (HP:0000734)5.14707298
6Loss of speech (HP:0002371)5.07630475
7Axonal loss (HP:0003447)4.57801813
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.52450517
9Nuclear cataract (HP:0100018)4.47447210
10Hypoglycemic coma (HP:0001325)4.34266532
11Neurofibrillary tangles (HP:0002185)4.20927420
12Abnormality of macrophages (HP:0004311)4.15714907
13Mutism (HP:0002300)4.14350603
14Systemic lupus erythematosus (HP:0002725)4.05078701
15Ketoacidosis (HP:0001993)3.93056334
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.89606713
17Xanthomatosis (HP:0000991)3.82042491
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.75488892
19Gout (HP:0001997)3.68407290
20Intrahepatic cholestasis (HP:0001406)3.66355598
21Vacuolated lymphocytes (HP:0001922)3.60265728
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.52871131
23Abnormality of the vasculature of the conjunctiva (HP:0008054)3.51571751
24Late onset (HP:0003584)3.50031627
25Hyperinsulinemic hypoglycemia (HP:0000825)3.43560920
26Urinary glycosaminoglycan excretion (HP:0003541)3.40145889
27Mucopolysacchariduria (HP:0008155)3.40145889
28Complement deficiency (HP:0004431)3.38357897
29Ketosis (HP:0001946)3.35074735
30Dysostosis multiplex (HP:0000943)3.31777402
31Right ventricular cardiomyopathy (HP:0011663)3.31243695
32Hyperglycinuria (HP:0003108)3.29246394
33Hypoglycemic seizures (HP:0002173)3.25992546
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.21582196
35Cerebral inclusion bodies (HP:0100314)3.18186327
36Upper motor neuron abnormality (HP:0002127)3.14874776
37Apathy (HP:0000741)3.13470682
38Deep venous thrombosis (HP:0002625)3.08970349
39Diminished motivation (HP:0000745)3.07908327
40Abnormality of mucopolysaccharide metabolism (HP:0011020)3.03850529
41Abnormality of polysaccharide metabolism (HP:0011012)3.03850529
42Abnormality of glycosaminoglycan metabolism (HP:0004371)3.03850529
43Hyperammonemia (HP:0001987)3.01796199
44Esophageal varix (HP:0002040)2.95619064
45Progressive neurologic deterioration (HP:0002344)2.93416471
46Recurrent bacterial skin infections (HP:0005406)2.92765238
47Abnormality of purine metabolism (HP:0004352)2.91864423
48Agnosia (HP:0010524)2.90704095
49Asymmetric septal hypertrophy (HP:0001670)2.89776183
50Abnormality of complement system (HP:0005339)2.86316162
51Recurrent abscess formation (HP:0002722)2.81551648
52Inappropriate behavior (HP:0000719)2.79448767
53Metaphyseal irregularity (HP:0003025)2.78988102
54Neuronal loss in central nervous system (HP:0002529)2.77611031
55Prolonged neonatal jaundice (HP:0006579)2.76453992
56Abnormality of proline metabolism (HP:0010907)2.68436022
57Hydroxyprolinuria (HP:0003080)2.68436022
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.66785348
59Eczematoid dermatitis (HP:0000976)2.66189301
60Malnutrition (HP:0004395)2.65232188
61Proximal tubulopathy (HP:0000114)2.56674394
62Hematochezia (HP:0002573)2.56228483
63Glomerulonephritis (HP:0000099)2.54117071
64Abnormality of serine family amino acid metabolism (HP:0010894)2.52886743
65Abnormality of glycine metabolism (HP:0010895)2.52886743
66Hypobetalipoproteinemia (HP:0003563)2.52164781
67Symptomatic seizures (HP:0011145)2.51766631
68Purpura (HP:0000979)2.51563773
69Abnormality of fatty-acid metabolism (HP:0004359)2.51137783
70Generalized aminoaciduria (HP:0002909)2.48781071
71Pathologic fracture (HP:0002756)2.46876178
72Dementia (HP:0000726)2.46199491
73Personality changes (HP:0000751)2.46093960
74Abnormality of nucleobase metabolism (HP:0010932)2.45623906
75Increased serum ferritin (HP:0003281)2.45302600
76Abnormality of chloride homeostasis (HP:0011422)2.37961214
77Fat malabsorption (HP:0002630)2.36080598
78Vertebral compression fractures (HP:0002953)2.34437308
79Hyperactive renin-angiotensin system (HP:0000841)2.33607348
80Abnormality of the intrinsic pathway (HP:0010989)2.32589662
81Vascular calcification (HP:0004934)2.29742339
82Mediastinal lymphadenopathy (HP:0100721)2.29698329
83Hepatocellular carcinoma (HP:0001402)2.27193595
84Conjunctival telangiectasia (HP:0000524)2.26231849
85Orchitis (HP:0100796)2.26195283
86Abnormality of the common coagulation pathway (HP:0010990)2.24422284
87Abnormality of sulfur amino acid metabolism (HP:0004339)2.23191200
88Hyperglycemia (HP:0003074)2.22274823
89Abnormality of endocrine pancreas physiology (HP:0012093)2.21952243
90Abnormality of the pancreatic islet cells (HP:0006476)2.21952243
91Bone pain (HP:0002653)2.21637531
92Cardiomegaly (HP:0001640)2.21617345
93Hyperglycinemia (HP:0002154)2.21406209
94Ventricular tachycardia (HP:0004756)2.18050965
95Prolonged partial thromboplastin time (HP:0003645)2.15669763
96Hyperuricemia (HP:0002149)2.15656910
97Increased purine levels (HP:0004368)2.15656910
98Hepatosplenomegaly (HP:0001433)2.14428218
99Nausea (HP:0002018)2.14215190
100Retinal atrophy (HP:0001105)2.10871329
101Abnormal enzyme/coenzyme activity (HP:0012379)2.10520711
102Hypolipoproteinemia (HP:0010981)2.09968932
103Myocardial infarction (HP:0001658)2.09679600
104J-shaped sella turcica (HP:0002680)2.08194233
105Peripheral demyelination (HP:0011096)2.07497580
106Abdominal distention (HP:0003270)2.05360278
107Sensorimotor neuropathy (HP:0007141)2.04225151
108Glycosuria (HP:0003076)2.03709121
109Abnormality of urine glucose concentration (HP:0011016)2.03709121
110Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03171792
111Basal ganglia calcification (HP:0002135)2.03078826
112Thoracic kyphosis (HP:0002942)2.02850091
113Joint hemorrhage (HP:0005261)2.02223280
114Pancreatic islet-cell hyperplasia (HP:0004510)2.01487797
115Abnormality of alkaline phosphatase activity (HP:0004379)2.01411865
116Myoglobinuria (HP:0002913)2.01348019
117Abnormal hemoglobin (HP:0011902)1.99302444
118Hypercholesterolemia (HP:0003124)1.99193988
119Spastic diplegia (HP:0001264)1.98968191
120Nephritis (HP:0000123)1.98818524
121Recurrent gram-negative bacterial infections (HP:0005420)1.98511829
122Amyloidosis (HP:0011034)1.97259135
123Back pain (HP:0003418)1.97106109
124Retrobulbar optic neuritis (HP:0100654)1.95338349
125Optic neuritis (HP:0100653)1.95338349
126Cardiovascular calcification (HP:0011915)1.95224033
127Skin nodule (HP:0200036)1.92967327
128Abnormality of renal excretion (HP:0011036)1.92566662
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92144313
130Dicarboxylic aciduria (HP:0003215)1.92144313
131Polycythemia (HP:0001901)1.92068997
132Hypoalphalipoproteinemia (HP:0003233)1.91780230
133Epidermoid cyst (HP:0200040)1.91431253
134Mesangial abnormality (HP:0001966)1.90717887
135Tetraparesis (HP:0002273)1.90295394
136Protuberant abdomen (HP:0001538)1.89794994
137Achilles tendon contracture (HP:0001771)1.89586525
138Supranuclear gaze palsy (HP:0000605)1.89024293
139Multiple enchondromatosis (HP:0005701)1.88865083
140Irritability (HP:0000737)1.87949410
141Abnormal urine output (HP:0012590)1.87307869
142Hyperlipoproteinemia (HP:0010980)1.87037875
143Alkalosis (HP:0001948)1.85380084
144Beaking of vertebral bodies (HP:0004568)1.84472235
145Palpitations (HP:0001962)1.84396329
146Interstitial pulmonary disease (HP:0006530)1.83640433
147Onycholysis (HP:0001806)1.83340740
148Global brain atrophy (HP:0002283)1.83156536
149Petechiae (HP:0000967)1.82984127
150Hypokalemic alkalosis (HP:0001949)1.82650030
151Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82388740
152Abnormality of the nasal mucosa (HP:0000433)1.82035147
153Zonular cataract (HP:0010920)1.81304996
154Autoimmune thrombocytopenia (HP:0001973)1.81212492
155Pustule (HP:0200039)1.81058966
156Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80791553
157Myositis (HP:0100614)1.80366076
158Hand muscle atrophy (HP:0009130)1.78974449
159Progressive visual loss (HP:0000529)1.78920309
160Abnormality of the lumbar spine (HP:0100712)1.74156814
161Abnormality of the Achilles tendon (HP:0005109)1.72591266
162Abnormality of iron homeostasis (HP:0011031)1.71244746
163Spontaneous hematomas (HP:0007420)1.69004712
164Stomatitis (HP:0010280)1.67628709
165Polyneuropathy (HP:0001271)1.66802016
166Spondylolisthesis (HP:0003302)1.66484091
167Increased CSF protein (HP:0002922)1.63046743
168Urinary incontinence (HP:0000020)1.61360057
169Memory impairment (HP:0002354)1.56741862
170Polygenic inheritance (HP:0010982)1.55964216
171Gingivitis (HP:0000230)1.55698806
172Mucosal telangiectasiae (HP:0100579)1.55660441
173Hyperparathyroidism (HP:0000843)1.54126733
174Thin bony cortex (HP:0002753)1.53877929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.93168769
2MST1R4.20275289
3ERN13.79794188
4TRIB32.96637503
5GRK72.91934618
6BCKDK2.81363580
7EPHA22.74950288
8MAPK152.73384572
9TAOK22.51618441
10MYLK2.37736603
11MET2.26257672
12ACVR1B2.13083368
13TAOK12.12007773
14LMTK22.11539718
15PKN22.09775267
16FGFR42.09023254
17FGR2.03749883
18WNK42.01856716
19MAP2K21.99650922
20PTK61.96912287
21TYK21.92387367
22RIPK11.90558974
23WNK31.73852013
24SIK11.72752806
25EPHB11.70297307
26INSRR1.67393651
27MOS1.60528341
28MST41.59921363
29PTK21.51251711
30MATK1.47917745
31TAOK31.46599029
32PRPF4B1.44620280
33PDGFRA1.42392525
34MAP3K21.40471116
35FLT31.39235007
36BMX1.38443782
37LATS21.33217027
38TESK11.32689625
39LRRK21.29065233
40IRAK41.28962313
41EPHA31.27317372
42TBK11.27297183
43MAP3K131.26473971
44MAP3K31.23278322
45FRK1.23053690
46ADRBK21.22003877
47SCYL21.19182516
48ARAF1.12994081
49ICK1.12517541
50PIK3CG1.09150900
51TESK21.08468113
52KDR1.06139685
53CSK1.06105550
54CAMK1D1.04976012
55STK38L1.04809602
56CSF1R1.04425979
57MAP3K140.98655841
58GRK60.98649602
59PRKG20.97665592
60BLK0.96610591
61MAP3K110.95542693
62DYRK1B0.94661223
63PAK40.93018950
64TGFBR20.91537433
65FER0.89950836
66TTN0.89441628
67TGFBR10.88388450
68MAPKAPK30.86053568
69ERBB40.85558647
70NEK90.85423994
71KIT0.83539932
72DDR20.83182231
73LIMK10.79823193
74TYRO30.79655498
75JAK20.76962337
76JAK10.75607285
77MAP2K10.74711198
78IRAK20.74414139
79MARK30.73418258
80GSK3A0.73237357
81STK100.72697539
82CDC42BPA0.72635400
83MAP3K10.69231049
84JAK30.68967459
85STK240.66491032
86EPHB20.65609003
87ZAP700.64671105
88CAMKK20.63988629
89LATS10.63710723
90MAP3K90.63636869
91DAPK30.63504316
92CHUK0.60584712
93MAP2K30.59810505
94RPS6KA40.59205581
95IRAK30.59159576
96NTRK10.58706063
97BMPR20.56779279
98PASK0.55236954
99KSR20.52841953
100MAP2K60.52302927
101MAPK110.51883216
102CDK60.50925412
103LYN0.48377406
104ABL20.48121557
105PRKD20.47040636
106TRPM70.46226125
107NEK10.44886846
108RIPK40.44575635
109DMPK0.44326670
110TIE10.42732225
111SIK30.42220225
112PRKAA20.41990187
113HIPK20.41934137
114EGFR0.41467091
115MAP3K50.40305262
116MAP4K10.40056796
117MAP3K80.39911310
118CAMK1G0.39091706
119IKBKE0.38135812
120RPS6KA20.36955689
121ILK0.36707870
122IKBKB0.36339197
123OBSCN0.36259938
124ERBB20.35612691
125PDPK10.35585467
126IGF1R0.35386044
127IRAK10.35073572
128RPS6KB20.35049770
129RPS6KC10.33229171
130RPS6KL10.33229171
131BRAF0.33144010
132PHKG10.32294786
133PHKG20.32294786
134NUAK10.32232349
135PDGFRB0.32094417
136PAK20.31922260
137PIM10.31688738
138MAPKAPK20.31172911
139PIM20.30732035
140PBK0.26225454
141ABL10.22596485
142CDK40.22106556
143PRKCD0.21529925
144PAK10.21308436
145INSR0.20607776
146RPS6KA60.18645490
147CLK10.17633458

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.99718682
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.80359138
3Rheumatoid arthritis_Homo sapiens_hsa053232.78219805
4Nitrogen metabolism_Homo sapiens_hsa009102.72016839
5Fatty acid degradation_Homo sapiens_hsa000712.69473528
6Tryptophan metabolism_Homo sapiens_hsa003802.51084413
7Osteoclast differentiation_Homo sapiens_hsa043802.37887520
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.36336720
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35034949
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27815607
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22175420
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20168764
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.15604408
14Sulfur metabolism_Homo sapiens_hsa009202.12411875
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11771101
16Arginine biosynthesis_Homo sapiens_hsa002202.06647923
17Leishmaniasis_Homo sapiens_hsa051402.05836125
18Asthma_Homo sapiens_hsa053102.03741165
19Complement and coagulation cascades_Homo sapiens_hsa046101.96955084
20Histidine metabolism_Homo sapiens_hsa003401.93548845
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.88685627
22Malaria_Homo sapiens_hsa051441.86598837
23TNF signaling pathway_Homo sapiens_hsa046681.86172251
24Tuberculosis_Homo sapiens_hsa051521.85324180
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81021134
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79782865
27Tyrosine metabolism_Homo sapiens_hsa003501.79214529
28Staphylococcus aureus infection_Homo sapiens_hsa051501.78372912
29Allograft rejection_Homo sapiens_hsa053301.78014468
30Salmonella infection_Homo sapiens_hsa051321.77776640
31Phenylalanine metabolism_Homo sapiens_hsa003601.77605182
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.75923701
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71376786
34Fat digestion and absorption_Homo sapiens_hsa049751.68562347
35Fatty acid metabolism_Homo sapiens_hsa012121.67593131
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61001546
37Other glycan degradation_Homo sapiens_hsa005111.60625269
38Phagosome_Homo sapiens_hsa041451.59275799
39PPAR signaling pathway_Homo sapiens_hsa033201.58175190
40Peroxisome_Homo sapiens_hsa041461.57049892
41Caffeine metabolism_Homo sapiens_hsa002321.56808775
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56289456
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54774988
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.53554238
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52396359
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48859116
47Bile secretion_Homo sapiens_hsa049761.48448861
48Propanoate metabolism_Homo sapiens_hsa006401.48429446
49Folate biosynthesis_Homo sapiens_hsa007901.47304601
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47069784
51Carbon metabolism_Homo sapiens_hsa012001.43993148
52Chemical carcinogenesis_Homo sapiens_hsa052041.42758146
53Sphingolipid metabolism_Homo sapiens_hsa006001.42724941
54Graft-versus-host disease_Homo sapiens_hsa053321.42530403
55beta-Alanine metabolism_Homo sapiens_hsa004101.42281153
56Galactose metabolism_Homo sapiens_hsa000521.40771520
57Butanoate metabolism_Homo sapiens_hsa006501.37707401
58Starch and sucrose metabolism_Homo sapiens_hsa005001.37607627
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36949064
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31183685
61Glutathione metabolism_Homo sapiens_hsa004801.31156539
62Biosynthesis of amino acids_Homo sapiens_hsa012301.29343199
63Autoimmune thyroid disease_Homo sapiens_hsa053201.28746430
64African trypanosomiasis_Homo sapiens_hsa051431.27447076
65Pyruvate metabolism_Homo sapiens_hsa006201.27007301
66Lysosome_Homo sapiens_hsa041421.26603344
67Vitamin digestion and absorption_Homo sapiens_hsa049771.25928883
68Vibrio cholerae infection_Homo sapiens_hsa051101.25528901
69Influenza A_Homo sapiens_hsa051641.23053099
70Fructose and mannose metabolism_Homo sapiens_hsa000511.22363624
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21839194
72Selenocompound metabolism_Homo sapiens_hsa004501.20770728
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17860608
74Arginine and proline metabolism_Homo sapiens_hsa003301.16687491
75Cyanoamino acid metabolism_Homo sapiens_hsa004601.15004547
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14201565
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13603750
78Type I diabetes mellitus_Homo sapiens_hsa049401.08796635
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07156458
80Shigellosis_Homo sapiens_hsa051311.04220212
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.96627530
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93993942
83Hematopoietic cell lineage_Homo sapiens_hsa046400.92753518
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90671088
85ABC transporters_Homo sapiens_hsa020100.86807912
86Pentose phosphate pathway_Homo sapiens_hsa000300.86350428
87Lysine degradation_Homo sapiens_hsa003100.81182764
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77142768
89Herpes simplex infection_Homo sapiens_hsa051680.77132004
90Mineral absorption_Homo sapiens_hsa049780.76226194
91Retinol metabolism_Homo sapiens_hsa008300.72443599
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72442991
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72417392
94Viral myocarditis_Homo sapiens_hsa054160.72332875
95Glycerolipid metabolism_Homo sapiens_hsa005610.72117795
96Apoptosis_Homo sapiens_hsa042100.71750203
97Chemokine signaling pathway_Homo sapiens_hsa040620.68660486
98Renin-angiotensin system_Homo sapiens_hsa046140.68169026
99Sulfur relay system_Homo sapiens_hsa041220.67842706
100B cell receptor signaling pathway_Homo sapiens_hsa046620.67560142
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67466761
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66133200
103Prion diseases_Homo sapiens_hsa050200.63547581
104Protein digestion and absorption_Homo sapiens_hsa049740.63045318
105Arachidonic acid metabolism_Homo sapiens_hsa005900.62393890
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62103135
107Hepatitis B_Homo sapiens_hsa051610.59925359
108Linoleic acid metabolism_Homo sapiens_hsa005910.59061983
109Insulin resistance_Homo sapiens_hsa049310.58471500
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58362919
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.55788652
112Acute myeloid leukemia_Homo sapiens_hsa052210.54324309
113Notch signaling pathway_Homo sapiens_hsa043300.51250553
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50608312
115Measles_Homo sapiens_hsa051620.50422364
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49043039
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45492425
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.45217900
119Fatty acid biosynthesis_Homo sapiens_hsa000610.44811573
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43542038
121One carbon pool by folate_Homo sapiens_hsa006700.42982230
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42683960
123Bladder cancer_Homo sapiens_hsa052190.42242996
124Legionellosis_Homo sapiens_hsa051340.41996979
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.41951394
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.41696727
127Epstein-Barr virus infection_Homo sapiens_hsa051690.41027213
128Endocytosis_Homo sapiens_hsa041440.40808195
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.40346747
130VEGF signaling pathway_Homo sapiens_hsa043700.39671584
131Thyroid hormone synthesis_Homo sapiens_hsa049180.39277551
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38002685
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.37022955
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.35613039
135Adherens junction_Homo sapiens_hsa045200.35453320
136Steroid biosynthesis_Homo sapiens_hsa001000.35026940
137Prolactin signaling pathway_Homo sapiens_hsa049170.33856428
138Metabolic pathways_Homo sapiens_hsa011000.33328390
139HIF-1 signaling pathway_Homo sapiens_hsa040660.31921444
140Proteoglycans in cancer_Homo sapiens_hsa052050.31591827
141Fatty acid elongation_Homo sapiens_hsa000620.31549083
142Pertussis_Homo sapiens_hsa051330.30436817
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28949399
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28794793
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28196845
146Chronic myeloid leukemia_Homo sapiens_hsa052200.28173429
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28013081
148Amoebiasis_Homo sapiens_hsa051460.27689869
149Toxoplasmosis_Homo sapiens_hsa051450.27016592
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.25429107
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24900369
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23217306
153Renal cell carcinoma_Homo sapiens_hsa052110.22996449
154HTLV-I infection_Homo sapiens_hsa051660.22161395
155Collecting duct acid secretion_Homo sapiens_hsa049660.21544537
156Small cell lung cancer_Homo sapiens_hsa052220.20729674
157Type II diabetes mellitus_Homo sapiens_hsa049300.20489468
158Pancreatic cancer_Homo sapiens_hsa052120.20374153
159Synaptic vesicle cycle_Homo sapiens_hsa047210.19852496
160Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19718449
161Tight junction_Homo sapiens_hsa045300.19060588
162Antigen processing and presentation_Homo sapiens_hsa046120.17737033
163Hepatitis C_Homo sapiens_hsa051600.17110747
164Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17088069
165Vitamin B6 metabolism_Homo sapiens_hsa007500.16596980
166Focal adhesion_Homo sapiens_hsa045100.16294719

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