TMEM52B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.84620497
2drug transport (GO:0015893)8.34099155
3organic cation transport (GO:0015695)8.14868032
4phosphate ion transport (GO:0006817)7.65933663
5lysine metabolic process (GO:0006553)7.38403903
6lysine catabolic process (GO:0006554)7.38403903
7excretion (GO:0007588)6.87086752
8renal absorption (GO:0070293)6.68158202
9drug catabolic process (GO:0042737)6.64903153
10exogenous drug catabolic process (GO:0042738)6.60840580
11quaternary ammonium group transport (GO:0015697)6.32597519
12glyoxylate metabolic process (GO:0046487)6.07023562
13metanephric tubule development (GO:0072170)6.03776161
14metanephric nephron tubule development (GO:0072234)6.03776161
15response to mercury ion (GO:0046689)5.99160405
16phosphate ion transmembrane transport (GO:0035435)5.97759701
17phosphate ion homeostasis (GO:0055062)5.94460478
18trivalent inorganic anion homeostasis (GO:0072506)5.94460478
19toxin transport (GO:1901998)5.76716349
20vitamin D metabolic process (GO:0042359)5.74600318
21metanephric nephron epithelium development (GO:0072243)5.60957253
22metanephric epithelium development (GO:0072207)5.36950444
23tricarboxylic acid metabolic process (GO:0072350)5.31046801
24nonribosomal peptide biosynthetic process (GO:0019184)5.21175098
25glycoside metabolic process (GO:0016137)5.20038401
26cysteine metabolic process (GO:0006534)5.16469651
27DNA deamination (GO:0045006)5.02800528
28short-chain fatty acid metabolic process (GO:0046459)4.84557938
29branched-chain amino acid metabolic process (GO:0009081)4.82232570
30nephron tubule development (GO:0072080)4.79306753
31homocysteine metabolic process (GO:0050667)4.74714558
32aspartate family amino acid catabolic process (GO:0009068)4.73425012
33glutathione biosynthetic process (GO:0006750)4.51946261
34valine metabolic process (GO:0006573)4.45975571
35behavioral response to nicotine (GO:0035095)4.44577999
36fucose catabolic process (GO:0019317)4.44069867
37L-fucose metabolic process (GO:0042354)4.44069867
38L-fucose catabolic process (GO:0042355)4.44069867
39tryptophan catabolic process (GO:0006569)4.32714611
40indole-containing compound catabolic process (GO:0042436)4.32714611
41indolalkylamine catabolic process (GO:0046218)4.32714611
42amino-acid betaine transport (GO:0015838)4.30798353
43carnitine transport (GO:0015879)4.30798353
44renal tubule development (GO:0061326)4.29199241
45aromatic amino acid family catabolic process (GO:0009074)4.23681874
46proline metabolic process (GO:0006560)4.18946905
47nephron tubule morphogenesis (GO:0072078)4.16839578
48nephron epithelium morphogenesis (GO:0072088)4.16839578
49modified amino acid transport (GO:0072337)4.16278127
50oligosaccharide catabolic process (GO:0009313)4.14317925
51nephron epithelium development (GO:0072009)4.06777607
52respiratory chain complex IV assembly (GO:0008535)4.06190497
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.03495791
54tryptophan metabolic process (GO:0006568)4.03215943
55polyol transport (GO:0015791)4.03062673
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.00742880
57L-phenylalanine metabolic process (GO:0006558)4.00742880
58response to pheromone (GO:0019236)3.99224974
59fructose metabolic process (GO:0006000)3.97037346
60water-soluble vitamin biosynthetic process (GO:0042364)3.97021890
61L-phenylalanine catabolic process (GO:0006559)3.94792235
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.94792235
63serine family amino acid catabolic process (GO:0009071)3.93951502
64branched-chain amino acid catabolic process (GO:0009083)3.91944496
65sodium-independent organic anion transport (GO:0043252)3.86567518
66cellular modified amino acid catabolic process (GO:0042219)3.86374032
67platelet dense granule organization (GO:0060155)3.83486701
68amino-acid betaine metabolic process (GO:0006577)3.82730232
69peptide biosynthetic process (GO:0043043)3.78114587
70protein complex biogenesis (GO:0070271)3.77151999
71response to parathyroid hormone (GO:0071107)3.70931064
72negative regulation of mast cell activation (GO:0033004)3.68391673
73positive regulation of prostaglandin secretion (GO:0032308)3.66200586
74sulfur compound transport (GO:0072348)3.65703698
75serine family amino acid metabolic process (GO:0009069)3.64722464
76carnitine metabolic process (GO:0009437)3.64107415
77fatty acid beta-oxidation (GO:0006635)3.64065005
78ubiquinone biosynthetic process (GO:0006744)3.61636647
79renal tubule morphogenesis (GO:0061333)3.60809374
80kynurenine metabolic process (GO:0070189)3.56964676
81cytochrome complex assembly (GO:0017004)3.56190727
82protein-cofactor linkage (GO:0018065)3.54795443
832-oxoglutarate metabolic process (GO:0006103)3.52975843
84preassembly of GPI anchor in ER membrane (GO:0016254)3.52871247
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.52744924
86NADH dehydrogenase complex assembly (GO:0010257)3.52744924
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52744924
88mitochondrial respiratory chain complex assembly (GO:0033108)3.52079324
89piRNA metabolic process (GO:0034587)3.51679850
90indole-containing compound metabolic process (GO:0042430)3.50618530
91negative regulation of telomere maintenance (GO:0032205)3.49020392
92sodium ion transport (GO:0006814)3.48999694
93response to growth hormone (GO:0060416)3.47591505
94peptide catabolic process (GO:0043171)3.46931768
95ketone body metabolic process (GO:1902224)3.46058475
96pyrimidine ribonucleoside catabolic process (GO:0046133)3.43923757
97cellular response to vitamin D (GO:0071305)3.40472994
98S-adenosylmethionine metabolic process (GO:0046500)3.39186075
99glomerular basement membrane development (GO:0032836)3.38632728
100response to magnesium ion (GO:0032026)3.38629021
101surfactant homeostasis (GO:0043129)3.37657316
102peptidyl-histidine modification (GO:0018202)3.37000269
103positive regulation of fatty acid transport (GO:2000193)3.35030445
104amino acid salvage (GO:0043102)3.35024266
105L-methionine salvage (GO:0071267)3.35024266
106L-methionine biosynthetic process (GO:0071265)3.35024266
107L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.34479643
108fatty acid oxidation (GO:0019395)3.33986460
109pseudouridine synthesis (GO:0001522)3.33012110
110response to phenylpropanoid (GO:0080184)3.30396272
111lipid oxidation (GO:0034440)3.29138847
112response to lead ion (GO:0010288)3.27205163
113vitamin catabolic process (GO:0009111)3.27075155
114fat-soluble vitamin catabolic process (GO:0042363)3.27075155
115ubiquinone metabolic process (GO:0006743)3.26253748
116regulation of apoptotic process involved in morphogenesis (GO:1902337)3.25004148
117mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.23440984
118acetyl-CoA metabolic process (GO:0006084)3.23390695
119sulfate transmembrane transport (GO:1902358)3.22812343
120detection of light stimulus involved in sensory perception (GO:0050962)3.22368745
121detection of light stimulus involved in visual perception (GO:0050908)3.22368745
122response to thyroid hormone (GO:0097066)3.22257731
123cellular ketone body metabolic process (GO:0046950)3.20980690
124polyol catabolic process (GO:0046174)3.16492851
125NADH metabolic process (GO:0006734)3.15949822
126glutathione metabolic process (GO:0006749)3.15695016
127protein polyglutamylation (GO:0018095)3.15193296
128detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15098327
129bone remodeling (GO:0046849)3.14443731
130regulation of cilium movement (GO:0003352)3.12880800
131activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.10551662
132cellular amino acid catabolic process (GO:0009063)3.10402492
133RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09157799
134alpha-amino acid catabolic process (GO:1901606)3.07369259
135cobalamin metabolic process (GO:0009235)3.07144058
136positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.06928193
137aromatic amino acid family metabolic process (GO:0009072)3.06879019
138indolalkylamine metabolic process (GO:0006586)3.05488460
139energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02273961
140ATP synthesis coupled proton transport (GO:0015986)3.02273961
141positive regulation of icosanoid secretion (GO:0032305)3.01481520
142axoneme assembly (GO:0035082)2.95752459
143mannosylation (GO:0097502)2.94887055
144epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91970294
145positive regulation of defense response to virus by host (GO:0002230)2.91490919
146methionine biosynthetic process (GO:0009086)2.88483083
147proteasome assembly (GO:0043248)2.88290633
148auditory receptor cell stereocilium organization (GO:0060088)2.86512744
149RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84585734
150tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84585734
151cellular biogenic amine catabolic process (GO:0042402)2.82736646
152amine catabolic process (GO:0009310)2.82736646
153regulation of prostaglandin secretion (GO:0032306)2.81533870
154quinone biosynthetic process (GO:1901663)2.79727016
155replication fork processing (GO:0031297)2.74236250
156cellular response to ATP (GO:0071318)2.74098845
157gamma-aminobutyric acid transport (GO:0015812)2.72919323
158iron-sulfur cluster assembly (GO:0016226)2.72563032
159metallo-sulfur cluster assembly (GO:0031163)2.72563032
160cornea development in camera-type eye (GO:0061303)2.72354267
161kidney morphogenesis (GO:0060993)2.65977710
162nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64469386
163tRNA processing (GO:0008033)2.62565778
164exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61467061
165regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61201537
166regulation of action potential (GO:0098900)2.60881308
167mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.60402353
168anterograde synaptic vesicle transport (GO:0048490)2.60334070
169protein K6-linked ubiquitination (GO:0085020)2.59013963
170nonmotile primary cilium assembly (GO:0035058)2.57058683
171epithelial cilium movement (GO:0003351)2.51772762
172DNA methylation involved in gamete generation (GO:0043046)2.50784302
173GPI anchor metabolic process (GO:0006505)2.49708385
174electron transport chain (GO:0022900)2.49441358
175DNA double-strand break processing (GO:0000729)2.49076142
176maturation of 5.8S rRNA (GO:0000460)2.47227015
177multicellular organism reproduction (GO:0032504)2.46875078
178C-terminal protein lipidation (GO:0006501)2.46405322
179male meiosis I (GO:0007141)2.45548371
180respiratory electron transport chain (GO:0022904)2.44205125
181cilium morphogenesis (GO:0060271)2.43592132
182cell wall macromolecule metabolic process (GO:0044036)2.43444884
183termination of RNA polymerase III transcription (GO:0006386)2.41208281
184transcription elongation from RNA polymerase III promoter (GO:0006385)2.41208281
185C-terminal protein amino acid modification (GO:0018410)2.40599888
186negative regulation of reactive oxygen species metabolic process (GO:2000378)2.38162200
187photoreceptor cell development (GO:0042461)2.37901036
188inositol phosphate catabolic process (GO:0071545)2.36785665
189phosphatidylinositol acyl-chain remodeling (GO:0036149)2.35626710
190aminoglycoside antibiotic metabolic process (GO:0030647)12.2657251
191urate metabolic process (GO:0046415)10.1200788

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.09772829
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.22624630
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.94962501
4VDR_22108803_ChIP-Seq_LS180_Human2.85104200
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.80901145
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63871823
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.52673158
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46836626
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.45960001
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.20509470
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.20406743
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.20045141
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.16441322
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13091558
15GBX2_23144817_ChIP-Seq_PC3_Human2.09724387
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06243609
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04973078
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.99273111
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97928249
20FUS_26573619_Chip-Seq_HEK293_Human1.95342854
21EWS_26573619_Chip-Seq_HEK293_Human1.94598088
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90383490
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.89344072
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86436083
25TP53_22573176_ChIP-Seq_HFKS_Human1.84947362
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80942295
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.80842289
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73774161
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73247600
30TAF15_26573619_Chip-Seq_HEK293_Human1.72928122
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72659215
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72134982
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71308518
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68203623
35ER_23166858_ChIP-Seq_MCF-7_Human1.68089390
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67525162
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.62228875
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61285568
39RXR_22108803_ChIP-Seq_LS180_Human1.58579214
40VDR_23849224_ChIP-Seq_CD4+_Human1.57948388
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57318292
42IRF1_19129219_ChIP-ChIP_H3396_Human1.55010119
43SMAD3_21741376_ChIP-Seq_HESCs_Human1.53398834
44MYC_18940864_ChIP-ChIP_HL60_Human1.53239771
45ELK1_19687146_ChIP-ChIP_HELA_Human1.52421787
46AR_20517297_ChIP-Seq_VCAP_Human1.52272946
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49558598
48SOX2_19829295_ChIP-Seq_ESCs_Human1.49108939
49NANOG_19829295_ChIP-Seq_ESCs_Human1.49108939
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46959573
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46629824
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.46343486
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.44902322
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.44533972
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42894094
56CBP_20019798_ChIP-Seq_JUKART_Human1.42894094
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42317380
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41647708
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.41647708
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40405754
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.40261542
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39647882
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37452326
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36421247
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36392004
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36052670
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33873534
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32674151
69EGR1_19032775_ChIP-ChIP_M12_Human1.31862217
70BCAT_22108803_ChIP-Seq_LS180_Human1.30804104
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30378646
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30319511
73AR_25329375_ChIP-Seq_VCAP_Human1.30128935
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30089484
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29814882
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29559507
77VDR_24787735_ChIP-Seq_THP-1_Human1.29490189
78TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.28886100
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28730086
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28209872
81NCOR_22424771_ChIP-Seq_293T_Human1.24869891
82HOXB7_26014856_ChIP-Seq_BT474_Human1.23602328
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23069157
84GATA3_26560356_Chip-Seq_TH2_Human1.22945030
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.22756413
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.22209901
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22198130
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21762073
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21452971
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20434426
91TCF4_23295773_ChIP-Seq_U87_Human1.20278348
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19350825
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19261222
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18821768
95IRF8_22096565_ChIP-ChIP_GC-B_Human1.18136457
96STAT3_23295773_ChIP-Seq_U87_Human1.17913626
97FOXP3_21729870_ChIP-Seq_TREG_Human1.17822078
98SMAD4_21741376_ChIP-Seq_HESCs_Human1.16831981
99AHR_22903824_ChIP-Seq_MCF-7_Human1.16771791
100CDX2_22108803_ChIP-Seq_LS180_Human1.15986981
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.15347563
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15327219
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14464847
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.14291422
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14245192
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.14229207
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.13667554
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12902883
109GATA4_25053715_ChIP-Seq_YYC3_Human1.12807169
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11696923
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11299390
112LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10706206
113FOXH1_21741376_ChIP-Seq_EPCs_Human1.10664677
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10290330
115JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09496712
116RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08845628
117EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08845628
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08672617
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.08180055
120EED_16625203_ChIP-ChIP_MESCs_Mouse1.08164409
121EZH2_22144423_ChIP-Seq_EOC_Human1.07912613
122ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07165027
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.06559449
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06478073
125AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05734126
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05321118
127MYC_19829295_ChIP-Seq_ESCs_Human1.04822734
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.03877754
129HNF4A_19822575_ChIP-Seq_HepG2_Human1.03143525
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01448365
131FOXO3_23340844_ChIP-Seq_DLD1_Human1.01315379
132NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00656073
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00656073
134SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99984788
135TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99975416
136GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99934486
137PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99770211
138CJUN_26792858_Chip-Seq_BT549_Human0.99435645
139CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99263419
140P300_19829295_ChIP-Seq_ESCs_Human0.98778124
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98358350
142FOXA2_19822575_ChIP-Seq_HepG2_Human0.98125461
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97817451
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97817451
145RUNX2_22187159_ChIP-Seq_PCA_Human0.97663182
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97107249
147* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95067768
148IGF1R_20145208_ChIP-Seq_DFB_Human0.94938909
149SMAD4_21799915_ChIP-Seq_A2780_Human0.94929049
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94758983
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94062874
152EZH2_27294783_Chip-Seq_NPCs_Mouse0.92828206
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92818784
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92701669
155TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92542572
156SOX2_20726797_ChIP-Seq_SW620_Human0.92198671
157TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91653276
158CLOCK_20551151_ChIP-Seq_293T_Human0.91311068
159SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91299650
160TP53_18474530_ChIP-ChIP_U2OS_Human0.90805326
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.90349606
162WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89144936
163PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89137028
164SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88995872
165SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88810703
166PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88778466
167BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88271464
168TCF4_22108803_ChIP-Seq_LS180_Human0.87045140
169OCT4_18555785_Chip-Seq_ESCs_Mouse0.86722963
170EZH2_27304074_Chip-Seq_ESCs_Mouse0.85975136
171P53_22387025_ChIP-Seq_ESCs_Mouse0.85268387
172TP63_23658742_ChIP-Seq_EP156T_Human0.85118019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation7.45943039
2MP0005360_urolithiasis6.61329727
3MP0004019_abnormal_vitamin_homeostasis5.13765269
4MP0005332_abnormal_amino_acid4.77093784
5MP0003195_calcinosis4.49470671
6MP0001765_abnormal_ion_homeostasis4.41052124
7MP0009643_abnormal_urine_homeostasis4.14029735
8MP0002138_abnormal_hepatobiliary_system4.08056980
9MP0002139_abnormal_hepatobiliary_system3.60797410
10MP0001756_abnormal_urination3.41434000
11MP0002136_abnormal_kidney_physiology3.40798677
12MP0005636_abnormal_mineral_homeostasis3.33761744
13MP0005377_hearing/vestibular/ear_phenot3.13776836
14MP0003878_abnormal_ear_physiology3.13776836
15MP0005646_abnormal_pituitary_gland3.08284217
16MP0001958_emphysema2.60710009
17MP0002102_abnormal_ear_morphology2.56376313
18MP0008877_abnormal_DNA_methylation2.47501246
19MP0005551_abnormal_eye_electrophysiolog2.38533863
20MP0003252_abnormal_bile_duct2.36646799
21MP0001968_abnormal_touch/_nociception2.33618936
22MP0008961_abnormal_basal_metabolism2.09578869
23MP0001986_abnormal_taste_sensitivity2.08719614
24MP0004885_abnormal_endolymph2.08349969
25MP0005058_abnormal_lysosome_morphology1.99799282
26MP0008875_abnormal_xenobiotic_pharmacok1.99467760
27MP0002736_abnormal_nociception_after1.88712134
28MP0003186_abnormal_redox_activity1.82058178
29MP0006072_abnormal_retinal_apoptosis1.81405749
30MP0002837_dystrophic_cardiac_calcinosis1.81098733
31MP0005365_abnormal_bile_salt1.73074959
32MP0009046_muscle_twitch1.71699335
33MP0000230_abnormal_systemic_arterial1.69202512
34MP0006292_abnormal_olfactory_placode1.64550574
35MP0002876_abnormal_thyroid_physiology1.63807962
36MP0001501_abnormal_sleep_pattern1.63610276
37MP0000372_irregular_coat_pigmentation1.62961589
38MP0005084_abnormal_gallbladder_morpholo1.62236988
39MP0002638_abnormal_pupillary_reflex1.61262360
40MP0005645_abnormal_hypothalamus_physiol1.59240263
41MP0000538_abnormal_urinary_bladder1.59152525
42MP0005253_abnormal_eye_physiology1.58868168
43MP0005085_abnormal_gallbladder_physiolo1.57251711
44MP0005451_abnormal_body_composition1.56422314
45MP0009745_abnormal_behavioral_response1.51942759
46MP0002272_abnormal_nervous_system1.47398933
47MP0004142_abnormal_muscle_tone1.46708495
48MP0002928_abnormal_bile_duct1.44986515
49MP0002653_abnormal_ependyma_morphology1.44476366
50MP0000427_abnormal_hair_cycle1.43358071
51MP0003786_premature_aging1.39555687
52MP0005584_abnormal_enzyme/coenzyme_acti1.39189641
53MP0006276_abnormal_autonomic_nervous1.33093771
54MP0003011_delayed_dark_adaptation1.32204510
55MP0002135_abnormal_kidney_morphology1.31920649
56MP0002168_other_aberrant_phenotype1.31901324
57MP0005670_abnormal_white_adipose1.30388932
58MP0005671_abnormal_response_to1.28258424
59MP0001486_abnormal_startle_reflex1.26769029
60MP0000569_abnormal_digit_pigmentation1.25654691
61MP0003880_abnormal_central_pattern1.23355998
62MP0008058_abnormal_DNA_repair1.22262212
63MP0001984_abnormal_olfaction1.21521550
64MP0010386_abnormal_urinary_bladder1.21019025
65MP0005389_reproductive_system_phenotype1.19672029
66MP0002938_white_spotting1.17146380
67MP0004133_heterotaxia1.15809481
68MP0009764_decreased_sensitivity_to1.13530855
69MP0003787_abnormal_imprinting1.13389751
70MP0003136_yellow_coat_color1.09691123
71MP0002148_abnormal_hypersensitivity_rea1.08592928
72MP0005319_abnormal_enzyme/_coenzyme1.07707878
73MP0000631_abnormal_neuroendocrine_gland1.05971381
74MP0001970_abnormal_pain_threshold1.04815842
75MP0004742_abnormal_vestibular_system1.04324733
76MP0005535_abnormal_body_temperature1.03641741
77MP0002277_abnormal_respiratory_mucosa1.03142298
78MP0003806_abnormal_nucleotide_metabolis1.03004679
79MP0002163_abnormal_gland_morphology1.01095035
80MP0002733_abnormal_thermal_nociception1.00766412
81MP0002160_abnormal_reproductive_system0.99577610
82MP0000013_abnormal_adipose_tissue0.99304275
83MP0005174_abnormal_tail_pigmentation0.98005148
84MP0005195_abnormal_posterior_eye0.96652159
85MP0002896_abnormal_bone_mineralization0.96278009
86MP0001502_abnormal_circadian_rhythm0.95827055
87MP0003300_gastrointestinal_ulcer0.95009082
88MP0003191_abnormal_cellular_cholesterol0.94284458
89MP0002095_abnormal_skin_pigmentation0.94008361
90MP0002572_abnormal_emotion/affect_behav0.92370456
91MP0000647_abnormal_sebaceous_gland0.92319941
92MP0002064_seizures0.92083712
93MP0002735_abnormal_chemical_nociception0.91961303
94MP0008995_early_reproductive_senescence0.89917665
95MP0003646_muscle_fatigue0.89578950
96MP0005410_abnormal_fertilization0.89241099
97MP0001485_abnormal_pinna_reflex0.88275013
98MP0001905_abnormal_dopamine_level0.87929908
99MP0001919_abnormal_reproductive_system0.87927877
100MP0002998_abnormal_bone_remodeling0.87385151
101MP0000678_abnormal_parathyroid_gland0.87152250
102MP0005379_endocrine/exocrine_gland_phen0.86728669
103MP0006036_abnormal_mitochondrial_physio0.84689750
104MP0001324_abnormal_eye_pigmentation0.84608775
105MP0003172_abnormal_lysosome_physiology0.84191103
106MP0004147_increased_porphyrin_level0.81571652
107MP0004215_abnormal_myocardial_fiber0.81430202
108MP0003718_maternal_effect0.81312880
109MP0002557_abnormal_social/conspecific_i0.80053012
110MP0003724_increased_susceptibility_to0.77632240
111MP0002067_abnormal_sensory_capabilities0.75174862
112MP0002693_abnormal_pancreas_physiology0.75007869
113MP0008789_abnormal_olfactory_epithelium0.74819504
114MP0000383_abnormal_hair_follicle0.73670661
115MP0005666_abnormal_adipose_tissue0.72591887
116MP0009642_abnormal_blood_homeostasis0.72387526
117MP0002234_abnormal_pharynx_morphology0.70559630
118MP0003638_abnormal_response/metabolism_0.69944883
119MP0002229_neurodegeneration0.69446462
120MP0001764_abnormal_homeostasis0.67251847
121MP0005395_other_phenotype0.65004962
122MP0002115_abnormal_skeleton_extremities0.62518102
123MP0003879_abnormal_hair_cell0.62486256
124MP0001963_abnormal_hearing_physiology0.62355463
125MP0003795_abnormal_bone_structure0.61031763
126MP0005165_increased_susceptibility_to0.60071482
127MP0004484_altered_response_of0.60006552
128MP0001879_abnormal_lymphatic_vessel0.59213618
129MP0002089_abnormal_postnatal_growth/wei0.59007009
130MP0008469_abnormal_protein_level0.58461546
131MP0003959_abnormal_lean_body0.56741358
132MP0002118_abnormal_lipid_homeostasis0.56501927
133MP0008872_abnormal_physiological_respon0.56347406
134MP0005310_abnormal_salivary_gland0.55821893
135MP0001661_extended_life_span0.55623292
136MP0004264_abnormal_extraembryonic_tissu0.54426126
137MP0000026_abnormal_inner_ear0.49265647
138MP0003315_abnormal_perineum_morphology0.45744332
139MP0005408_hypopigmentation0.45543178
140MP0002069_abnormal_eating/drinking_beha0.44545122
141MP0004272_abnormal_basement_membrane0.44144197
142MP0005220_abnormal_exocrine_pancreas0.44137647
143MP0000371_diluted_coat_color0.43828639
144MP0001666_abnormal_nutrient_absorption0.43292112
145MP0000163_abnormal_cartilage_morphology0.41541173
146MP0005166_decreased_susceptibility_to0.41482623
147MP0001663_abnormal_digestive_system0.41432807
148MP0000534_abnormal_ureter_morphology0.41362665
149MP0003953_abnormal_hormone_level0.40736898
150MP0003075_altered_response_to0.39241095
151MP0003183_abnormal_peptide_metabolism0.38467962
152MP0004782_abnormal_surfactant_physiolog0.38411897
153MP0002113_abnormal_skeleton_development0.37922223
154MP0004858_abnormal_nervous_system0.37401236
155MP0005595_abnormal_vascular_smooth0.35102252
156MP0001664_abnormal_digestion0.34683601
157MP0008775_abnormal_heart_ventricle0.34464238
158MP0001270_distended_abdomen0.33928624
159MP0001845_abnormal_inflammatory_respons0.33069105
160MP0002098_abnormal_vibrissa_morphology0.32605146
161MP0002972_abnormal_cardiac_muscle0.32237287
162MP0005167_abnormal_blood-brain_barrier0.31993935
163MP0008260_abnormal_autophagy0.31883961
164MP0008004_abnormal_stomach_pH0.31881439
165MP0003941_abnormal_skin_development0.31538830
166MP0005501_abnormal_skin_physiology0.30958697
167MP0002796_impaired_skin_barrier0.29125379

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)9.80442398
2Hypokalemic alkalosis (HP:0001949)8.81366154
3Hypomagnesemia (HP:0002917)8.15584559
4Metabolic alkalosis (HP:0200114)8.03614811
5Hyperactive renin-angiotensin system (HP:0000841)7.55555848
6Polyuria (HP:0000103)7.25992803
7Abnormality of chloride homeostasis (HP:0011422)7.01105987
8Abnormality of magnesium homeostasis (HP:0004921)6.88842449
9Abnormal urine output (HP:0012590)6.69135255
10Abnormality of renal excretion (HP:0011036)6.39129297
11Polydipsia (HP:0001959)6.23737440
12Abnormal drinking behavior (HP:0030082)6.23737440
13Tetany (HP:0001281)6.22891652
14Gout (HP:0001997)6.17242003
15Abnormality of renin-angiotensin system (HP:0000847)5.96704368
16Alkalosis (HP:0001948)5.57700784
17Hyperaldosteronism (HP:0000859)5.20867699
18Renal salt wasting (HP:0000127)4.97902283
19Proximal tubulopathy (HP:0000114)4.74198311
20Hypokalemia (HP:0002900)4.46401193
21Pancreatic cysts (HP:0001737)4.44538522
22Increased purine levels (HP:0004368)4.41897914
23Hyperuricemia (HP:0002149)4.41897914
24Type II lissencephaly (HP:0007260)4.19427307
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.06750659
26Abnormality of potassium homeostasis (HP:0011042)3.83667435
27Abnormality of purine metabolism (HP:0004352)3.80747262
28Hyperglycinuria (HP:0003108)3.79579669
29Hypercalciuria (HP:0002150)3.78919967
30Pancreatic fibrosis (HP:0100732)3.75496913
31Generalized aminoaciduria (HP:0002909)3.63910141
32True hermaphroditism (HP:0010459)3.62207624
33Molar tooth sign on MRI (HP:0002419)3.62120299
34Abnormality of midbrain morphology (HP:0002418)3.62120299
35Renal tubular acidosis (HP:0001947)3.38562909
36Abolished electroretinogram (ERG) (HP:0000550)3.31331623
37Congenital stationary night blindness (HP:0007642)3.27002377
38Nephronophthisis (HP:0000090)3.17280819
39Abnormality of the renal medulla (HP:0100957)3.16315588
40Cerebellar dysplasia (HP:0007033)3.15184886
41Glycosuria (HP:0003076)3.11266072
42Abnormality of urine glucose concentration (HP:0011016)3.11266072
43Abnormality of glycine metabolism (HP:0010895)3.03371548
44Abnormality of serine family amino acid metabolism (HP:0010894)3.03371548
45Hydroxyprolinuria (HP:0003080)2.94843207
46Abnormality of proline metabolism (HP:0010907)2.94843207
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.93579317
48Nephrocalcinosis (HP:0000121)2.90626416
49Abnormality of nucleobase metabolism (HP:0010932)2.86956916
50Ketoacidosis (HP:0001993)2.79947448
51Delayed epiphyseal ossification (HP:0002663)2.78741529
52Acute necrotizing encephalopathy (HP:0006965)2.78124139
53Abnormal urine phosphate concentration (HP:0012599)2.71963967
54Increased CSF lactate (HP:0002490)2.71796092
55Hyperphosphaturia (HP:0003109)2.70696575
56Retinal dysplasia (HP:0007973)2.68229065
57Medial flaring of the eyebrow (HP:0010747)2.68118345
58Abnormal rod and cone electroretinograms (HP:0008323)2.66602911
59Vascular calcification (HP:0004934)2.65776477
60Mitochondrial inheritance (HP:0001427)2.62522379
61Abnormality of alanine metabolism (HP:0010916)2.60147432
62Hyperalaninemia (HP:0003348)2.60147432
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60147432
64Hypophosphatemia (HP:0002148)2.57984187
65Attenuation of retinal blood vessels (HP:0007843)2.55892889
66Hyponatremia (HP:0002902)2.55824387
67Cystic liver disease (HP:0006706)2.55653903
68Renal cortical cysts (HP:0000803)2.53017964
69Abnormality of sodium homeostasis (HP:0010931)2.52218714
70Tubular atrophy (HP:0000092)2.50400712
71Abnormal mitochondria in muscle tissue (HP:0008316)2.50094837
72Abnormality of renal resorption (HP:0011038)2.46410497
73Progressive macrocephaly (HP:0004481)2.45345352
74Chondrocalcinosis (HP:0000934)2.44843815
75Pendular nystagmus (HP:0012043)2.44565743
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43146717
77Acute encephalopathy (HP:0006846)2.42423866
78Abnormality of Sharpey fibers (HP:0100685)2.39496633
79Rickets (HP:0002748)2.36380997
80Bilateral sensorineural hearing impairment (HP:0008619)2.36055289
81Dehydration (HP:0001944)2.34760662
82Cardiovascular calcification (HP:0011915)2.34112338
83Ketosis (HP:0001946)2.33422134
84Nephrolithiasis (HP:0000787)2.33421471
85Lipid accumulation in hepatocytes (HP:0006561)2.30522394
86Decreased central vision (HP:0007663)2.30118438
87Widely patent fontanelles and sutures (HP:0004492)2.29291668
88Vacuolated lymphocytes (HP:0001922)2.28966719
89Severe muscular hypotonia (HP:0006829)2.27784474
90Enlarged kidneys (HP:0000105)2.27732764
91Adrenal overactivity (HP:0002717)2.27111823
92Chronic hepatic failure (HP:0100626)2.23639483
93Hepatic necrosis (HP:0002605)2.21502562
94Generalized muscle weakness (HP:0003324)2.19867719
95Abnormality of fatty-acid metabolism (HP:0004359)2.18257228
96Metaphyseal cupping (HP:0003021)2.18022862
97Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16950508
983-Methylglutaconic aciduria (HP:0003535)2.16215179
99Abnormal biliary tract physiology (HP:0012439)2.15377815
100Bile duct proliferation (HP:0001408)2.15377815
101Abnormality of the pons (HP:0007361)2.12573146
102Hypoplasia of the pons (HP:0012110)2.11959252
103Hepatocellular necrosis (HP:0001404)2.11755734
104Sclerocornea (HP:0000647)2.10396436
105Nephrogenic diabetes insipidus (HP:0009806)2.09906612
106Renal tubular dysfunction (HP:0000124)2.06889060
107Glomerulosclerosis (HP:0000096)2.06420747
108Congenital hepatic fibrosis (HP:0002612)2.06339803
109Hyperglycinemia (HP:0002154)2.05229355
110Keratoconus (HP:0000563)2.03613116
111Increased corneal curvature (HP:0100692)2.03613116
112Hypothermia (HP:0002045)2.03296743
113Decreased circulating renin level (HP:0003351)2.02124911
114Lissencephaly (HP:0001339)2.02048470
115Tubulointerstitial fibrosis (HP:0005576)2.01260868
116Abnormal enzyme/coenzyme activity (HP:0012379)2.01217732
117Abnormality of alkaline phosphatase activity (HP:0004379)1.97388266
118Aplasia/hypoplasia of the uterus (HP:0008684)1.97022972
119Furrowed tongue (HP:0000221)1.96515728
120Hyperventilation (HP:0002883)1.96347987
121Metaphyseal dysplasia (HP:0100255)1.96142820
122Increased serum lactate (HP:0002151)1.95921145
123Optic disc pallor (HP:0000543)1.95892767
124Progressive inability to walk (HP:0002505)1.95402021
125Abnormality of macular pigmentation (HP:0008002)1.95146423
126Hyperkalemia (HP:0002153)1.94271651
127Aplasia/Hypoplasia of the spleen (HP:0010451)1.91424634
128Anencephaly (HP:0002323)1.89748763
129Increased hepatocellular lipid droplets (HP:0006565)1.88735261
130Stomatitis (HP:0010280)1.88379068
131Pachygyria (HP:0001302)1.88001669
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.87723371
133Stomach cancer (HP:0012126)1.83522292
134Gait imbalance (HP:0002141)1.83191670
135Congenital primary aphakia (HP:0007707)1.83096200
136Vomiting (HP:0002013)1.83093360
137Metabolic acidosis (HP:0001942)1.83075509
138Retinal atrophy (HP:0001105)1.78157121
139Inability to walk (HP:0002540)1.77020521
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75529931
141Dicarboxylic aciduria (HP:0003215)1.75529931
142Methylmalonic acidemia (HP:0002912)1.73988391
143Paralysis (HP:0003470)1.73501431
144Abnormal tarsal ossification (HP:0008369)1.73444244
145Postaxial foot polydactyly (HP:0001830)1.72864188
146Potter facies (HP:0002009)1.72647839
147Facial shape deformation (HP:0011334)1.72647839
148Large for gestational age (HP:0001520)1.70828570
149Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69876811
150Thin bony cortex (HP:0002753)1.69758905
151Asplenia (HP:0001746)1.69276573
152Elevated erythrocyte sedimentation rate (HP:0003565)1.67684423
153Hyperammonemia (HP:0001987)1.67614488
154Lymphangioma (HP:0100764)1.67562102
155Concave nail (HP:0001598)1.67369349
156Cerebral edema (HP:0002181)1.67055757
157Methylmalonic aciduria (HP:0012120)1.66902655
158Delayed CNS myelination (HP:0002188)1.66188096
159Abnormality of the costochondral junction (HP:0000919)1.65770930
160Focal segmental glomerulosclerosis (HP:0000097)1.65384463
161Elevated alkaline phosphatase (HP:0003155)1.65167484
162Confusion (HP:0001289)1.63081114
163Abnormality of calcium-phosphate metabolism (HP:0100530)1.61036299
164Metaphyseal irregularity (HP:0003025)1.60120350
165Axonal loss (HP:0003447)1.57988890
166Nausea (HP:0002018)1.55400224
167Hypotension (HP:0002615)1.55194120
168Malnutrition (HP:0004395)1.52341150
169Alveolar cell carcinoma (HP:0006519)1.48399299
170Hypophosphatemic rickets (HP:0004912)1.48178308
171Lethargy (HP:0001254)1.47225780
172Abnormality of the renal cortex (HP:0011035)1.47051064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR18.19986219
2STK396.63285277
3WNK35.63557448
4BMPR1B3.53396824
5MAP4K22.86298777
6ZAK2.52198565
7NUAK12.29773898
8TAOK32.04771110
9WNK410.5626343
10TLK11.99176666
11STK38L1.86691016
12WNK11.84667928
13SGK4941.69515765
14SGK2231.69515765
15TGFBR21.60217722
16ACVR1B1.48687351
17MAPK131.38765130
18PDK21.36346534
19MAP3K41.30776724
20SGK21.28031100
21BCKDK1.19890607
22DAPK21.14577285
23TIE11.13330296
24PDK41.09696813
25PDK31.09696813
26PLK21.09399738
27MAPKAPK31.02127854
28SGK31.01833084
29CDK81.00574850
30CSNK1G30.98814295
31CSNK1G10.98158755
32IKBKB0.97948579
33DYRK20.97798775
34CSNK1A1L0.95511778
35MUSK0.93816730
36INSRR0.90547469
37TRIM280.89591269
38EIF2AK30.89479778
39CSNK1G20.89223651
40CAMKK20.88468334
41MAP3K140.80882178
42MST40.80866962
43MKNK20.80054521
44BRSK20.78925734
45STK160.76282649
46SIK30.75578516
47ERBB30.75548334
48STK380.75382686
49TEC0.74278805
50VRK10.71254742
51VRK20.70113895
52IRAK10.69772121
53NEK10.69330006
54PRKCG0.68857779
55KIT0.67327593
56NME10.65262534
57MAP2K70.65219673
58PINK10.64176660
59MST1R0.63735216
60MAPKAPK50.59465875
61LIMK10.59168019
62FLT30.58783007
63PHKG10.57356646
64PHKG20.57356646
65CASK0.57023847
66SGK10.52130297
67RPS6KA50.51751558
68CSNK1A10.49900411
69ITK0.48734874
70MAP2K60.46503789
71PLK30.46004420
72FGFR40.45110905
73MAP2K20.44962223
74GSK3A0.44677141
75EPHB10.43913682
76LATS10.43418682
77EPHA30.42798928
78EPHB20.41708816
79MAPK150.41343354
80NLK0.40208621
81STK100.38978110
82SRPK10.38310133
83MYLK0.37566421
84GRK70.36740936
85BCR0.36541224
86PAK40.36242542
87PLK40.35723623
88PIK3CA0.34965349
89TNIK0.34472095
90CAMK2A0.34022457
91SYK0.33801794
92EIF2AK20.33648255
93IRAK30.33320223
94NEK60.32807166
95PRKAA20.32487275
96CAMK10.31855644
97MKNK10.31555104
98ABL10.31400415
99MAPK110.30032354
100CSNK1D0.29148120
101CCNB10.28881847
102MAP3K70.28184114
103FER0.26386616
104SIK20.25519364
105DYRK1B0.24557238
106TGFBR10.24368042
107ADRBK20.24093714
108LRRK20.24041698
109PRKAA10.23636675
110MAPK120.21599933
111MAP3K30.20818689
112PDPK10.20342995
113ABL20.19933356
114AKT30.19892438
115PRPF4B0.19254374
116FRK0.17959888
117NEK90.17545080
118PRKD20.17072445
119STK30.17020590
120PKN10.16435899
121PDK10.15758481
122MARK30.14644166
123PIM10.14575093
124KDR0.14362378
125PRKCD0.14287238
126PRKCI0.13959859
127PTK2B0.13136602
128YES10.13079342
129PTK20.12001137
130MET0.11835110
131STK110.10060126
132TYK20.10033603
133PRKCE0.09836456
134PRKCZ0.09622054
135TXK0.08614228
136GRK10.07883301
137CHUK0.06735184
138GRK60.06664459
139JAK20.06171816
140PRKACA0.06168009
141PRKACG0.06167329
142PRKCA0.05432216
143EPHA40.05341928
144IGF1R0.04767165
145BMPR20.04691856
146CAMK40.04130885
147IKBKE0.02643860
148BLK0.02589622
149PRKCQ0.02570600
150PRKCH0.02334779
151CSK0.02296829
152MAPK70.02156735
153INSR0.02071108
154MAP3K130.02005800
155ROCK10.01763815
156TAOK20.01499983
157MAP3K120.01340136
158PAK30.00903678
159TNK20.00774153
160ADRBK10.00769323
161SRC0.00552016
162GRK50.00189096

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.59354283
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.48931288
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.46966481
4Butanoate metabolism_Homo sapiens_hsa006503.45858538
5Collecting duct acid secretion_Homo sapiens_hsa049663.22653284
6Propanoate metabolism_Homo sapiens_hsa006403.12416433
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.09742864
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04195048
9Pentose and glucuronate interconversions_Homo sapiens_hsa000403.00233026
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.86631557
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.78076108
12Phototransduction_Homo sapiens_hsa047442.63333220
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53769433
14Peroxisome_Homo sapiens_hsa041462.43781237
15Vitamin digestion and absorption_Homo sapiens_hsa049772.42635982
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36045890
17Fatty acid degradation_Homo sapiens_hsa000712.12725806
18Tryptophan metabolism_Homo sapiens_hsa003802.12494807
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11713500
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.10228293
21Pyruvate metabolism_Homo sapiens_hsa006202.05149001
22beta-Alanine metabolism_Homo sapiens_hsa004102.01339881
23Linoleic acid metabolism_Homo sapiens_hsa005911.99342523
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93383873
25RNA polymerase_Homo sapiens_hsa030201.85902273
26Protein export_Homo sapiens_hsa030601.79263933
27Other glycan degradation_Homo sapiens_hsa005111.79237284
28Homologous recombination_Homo sapiens_hsa034401.78411047
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78304924
30Mineral absorption_Homo sapiens_hsa049781.77380140
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.75401431
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.71043827
33Proteasome_Homo sapiens_hsa030501.68825941
34One carbon pool by folate_Homo sapiens_hsa006701.67707205
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66375563
36Ether lipid metabolism_Homo sapiens_hsa005651.62975571
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55247384
38Glutathione metabolism_Homo sapiens_hsa004801.55057905
39Asthma_Homo sapiens_hsa053101.53626327
40Bile secretion_Homo sapiens_hsa049761.50719730
41Sulfur metabolism_Homo sapiens_hsa009201.50166442
42Fatty acid metabolism_Homo sapiens_hsa012121.49785996
43Protein digestion and absorption_Homo sapiens_hsa049741.47680760
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43762603
45Arginine and proline metabolism_Homo sapiens_hsa003301.41309859
46Lysine degradation_Homo sapiens_hsa003101.38659881
47Huntingtons disease_Homo sapiens_hsa050161.36935839
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36335533
49Basal transcription factors_Homo sapiens_hsa030221.34989906
50Type I diabetes mellitus_Homo sapiens_hsa049401.32560800
51RNA degradation_Homo sapiens_hsa030181.32539947
52Carbon metabolism_Homo sapiens_hsa012001.29520351
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29496829
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28792553
55Alzheimers disease_Homo sapiens_hsa050101.28584266
56Fanconi anemia pathway_Homo sapiens_hsa034601.27904574
57Caffeine metabolism_Homo sapiens_hsa002321.26299551
58Graft-versus-host disease_Homo sapiens_hsa053321.20000803
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16383220
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13009299
61Nicotine addiction_Homo sapiens_hsa050331.11898260
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11508768
63Renin-angiotensin system_Homo sapiens_hsa046141.07862584
64PPAR signaling pathway_Homo sapiens_hsa033201.05262765
65Starch and sucrose metabolism_Homo sapiens_hsa005001.04603842
66Histidine metabolism_Homo sapiens_hsa003400.96707676
67Allograft rejection_Homo sapiens_hsa053300.95362127
68Phenylalanine metabolism_Homo sapiens_hsa003600.94208622
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92326956
70Pyrimidine metabolism_Homo sapiens_hsa002400.91406772
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91405237
72Purine metabolism_Homo sapiens_hsa002300.89196019
73Folate biosynthesis_Homo sapiens_hsa007900.86021941
74Lysosome_Homo sapiens_hsa041420.85711943
75Autoimmune thyroid disease_Homo sapiens_hsa053200.85494639
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83677870
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81749851
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81310533
79Olfactory transduction_Homo sapiens_hsa047400.81084578
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79137338
81Sulfur relay system_Homo sapiens_hsa041220.77094206
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77065172
83Morphine addiction_Homo sapiens_hsa050320.75698260
84Arginine biosynthesis_Homo sapiens_hsa002200.74422091
85Glycerolipid metabolism_Homo sapiens_hsa005610.73009391
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.71694623
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.68346209
88Fructose and mannose metabolism_Homo sapiens_hsa000510.66651903
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66580908
90Arachidonic acid metabolism_Homo sapiens_hsa005900.65540937
91Gastric acid secretion_Homo sapiens_hsa049710.63696781
92Primary immunodeficiency_Homo sapiens_hsa053400.63193936
93Oxidative phosphorylation_Homo sapiens_hsa001900.62977146
94Fatty acid elongation_Homo sapiens_hsa000620.61152510
95Rheumatoid arthritis_Homo sapiens_hsa053230.60306550
96Ribosome_Homo sapiens_hsa030100.59614152
97Taste transduction_Homo sapiens_hsa047420.58871105
98Thyroid hormone synthesis_Homo sapiens_hsa049180.58695762
99Selenocompound metabolism_Homo sapiens_hsa004500.57249615
100Insulin secretion_Homo sapiens_hsa049110.56722590
101GABAergic synapse_Homo sapiens_hsa047270.52402745
102Non-homologous end-joining_Homo sapiens_hsa034500.51959912
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.51340666
104Vibrio cholerae infection_Homo sapiens_hsa051100.50468585
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50132942
106Ovarian steroidogenesis_Homo sapiens_hsa049130.49225553
107Base excision repair_Homo sapiens_hsa034100.47151833
108Metabolic pathways_Homo sapiens_hsa011000.46989042
109Synaptic vesicle cycle_Homo sapiens_hsa047210.46803082
110Biosynthesis of amino acids_Homo sapiens_hsa012300.46075980
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.45201272
112Serotonergic synapse_Homo sapiens_hsa047260.42462024
113Chemical carcinogenesis_Homo sapiens_hsa052040.42442407
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41790442
115Retinol metabolism_Homo sapiens_hsa008300.40274422
116Nucleotide excision repair_Homo sapiens_hsa034200.37691762
117Circadian rhythm_Homo sapiens_hsa047100.35795790
118Salivary secretion_Homo sapiens_hsa049700.35778476
119Circadian entrainment_Homo sapiens_hsa047130.32132871
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.32047860
121Choline metabolism in cancer_Homo sapiens_hsa052310.30605922
122ABC transporters_Homo sapiens_hsa020100.30207484
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30075490
124Hematopoietic cell lineage_Homo sapiens_hsa046400.29038841
125Sphingolipid metabolism_Homo sapiens_hsa006000.25660303
126Phagosome_Homo sapiens_hsa041450.25133661
127Pentose phosphate pathway_Homo sapiens_hsa000300.21772583
128Inositol phosphate metabolism_Homo sapiens_hsa005620.21543611
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.18612122
130Nitrogen metabolism_Homo sapiens_hsa009100.18542613
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17098508
132Steroid biosynthesis_Homo sapiens_hsa001000.15787541
133Regulation of autophagy_Homo sapiens_hsa041400.14968498
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14367597
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10809551
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09413324
137Parkinsons disease_Homo sapiens_hsa050120.08980719
138Tyrosine metabolism_Homo sapiens_hsa003500.08095192
139Hepatitis C_Homo sapiens_hsa051600.06834637
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.06309872
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05828225
142ECM-receptor interaction_Homo sapiens_hsa045120.04321890
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03502290
144FoxO signaling pathway_Homo sapiens_hsa040680.00550205
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.00469771
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0624696
147Cardiac muscle contraction_Homo sapiens_hsa04260-0.0477893
148Bladder cancer_Homo sapiens_hsa05219-0.0285412
149Tuberculosis_Homo sapiens_hsa05152-0.0192949
150Melanoma_Homo sapiens_hsa05218-0.0117114

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