TMEM53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)6.83944068
2acrosome reaction (GO:0007340)6.08013307
3cell wall macromolecule catabolic process (GO:0016998)5.88572793
4cell wall macromolecule metabolic process (GO:0044036)5.88572793
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.88189058
6L-phenylalanine catabolic process (GO:0006559)5.88189058
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.61954971
8L-phenylalanine metabolic process (GO:0006558)5.61954971
9fusion of sperm to egg plasma membrane (GO:0007342)5.43638050
10sperm-egg recognition (GO:0035036)5.09406247
11aromatic amino acid family catabolic process (GO:0009074)5.04297517
12organic cation transport (GO:0015695)4.94978302
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.85791579
14acrosome assembly (GO:0001675)4.81868889
15glyoxylate metabolic process (GO:0046487)4.78343598
16binding of sperm to zona pellucida (GO:0007339)4.73654635
17epithelial cilium movement (GO:0003351)4.72260619
18axonemal dynein complex assembly (GO:0070286)4.69154223
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.66483163
20sulfur amino acid catabolic process (GO:0000098)4.56588778
21alpha-linolenic acid metabolic process (GO:0036109)4.55982043
22regulation of cholesterol esterification (GO:0010872)4.55248623
23high-density lipoprotein particle remodeling (GO:0034375)4.49875151
24cell-cell recognition (GO:0009988)4.48802560
25cellular glucuronidation (GO:0052695)4.37752801
26regulation of triglyceride catabolic process (GO:0010896)4.36399418
27tryptophan catabolic process (GO:0006569)4.35242335
28indole-containing compound catabolic process (GO:0042436)4.35242335
29indolalkylamine catabolic process (GO:0046218)4.35242335
30bile acid biosynthetic process (GO:0006699)4.33559089
31spermatid development (GO:0007286)4.33373268
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.30622877
33kynurenine metabolic process (GO:0070189)4.27925934
34multicellular organism reproduction (GO:0032504)4.27709694
35amino-acid betaine metabolic process (GO:0006577)4.27008920
36urea cycle (GO:0000050)4.23045466
37urea metabolic process (GO:0019627)4.23045466
38motile cilium assembly (GO:0044458)4.21447526
39protein complex biogenesis (GO:0070271)4.20474947
40cilium movement (GO:0003341)4.15090976
41plasma membrane fusion (GO:0045026)4.11081470
42tryptophan metabolic process (GO:0006568)4.11034155
43glucuronate metabolic process (GO:0019585)4.08549717
44uronic acid metabolic process (GO:0006063)4.08549717
45negative regulation of fibrinolysis (GO:0051918)4.07437856
46protein-lipid complex remodeling (GO:0034368)4.06174779
47macromolecular complex remodeling (GO:0034367)4.06174779
48plasma lipoprotein particle remodeling (GO:0034369)4.06174779
49ATP synthesis coupled proton transport (GO:0015986)3.98170830
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.98170830
51cysteine metabolic process (GO:0006534)3.96863866
52nitrogen cycle metabolic process (GO:0071941)3.92563144
53reverse cholesterol transport (GO:0043691)3.91841817
54regulation of fibrinolysis (GO:0051917)3.90250935
55reproduction (GO:0000003)3.89300253
56protein neddylation (GO:0045116)3.88943704
57mitochondrial respiratory chain complex assembly (GO:0033108)3.85964691
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.85883464
59lysine metabolic process (GO:0006553)3.85010841
60lysine catabolic process (GO:0006554)3.85010841
61regulation of cilium movement (GO:0003352)3.84879895
62oxidative demethylation (GO:0070989)3.84288785
63peptidyl-glutamic acid carboxylation (GO:0017187)3.82547420
64protein carboxylation (GO:0018214)3.82547420
65low-density lipoprotein particle remodeling (GO:0034374)3.81573145
66carnitine metabolic process (GO:0009437)3.81541197
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81363692
68mitochondrial respiratory chain complex I assembly (GO:0032981)3.81363692
69NADH dehydrogenase complex assembly (GO:0010257)3.81363692
70serine family amino acid catabolic process (GO:0009071)3.77838083
71complement activation, alternative pathway (GO:0006957)3.73628968
72tyrosine metabolic process (GO:0006570)3.70072404
73water-soluble vitamin biosynthetic process (GO:0042364)3.70025188
74respiratory chain complex IV assembly (GO:0008535)3.66507817
75ubiquinone biosynthetic process (GO:0006744)3.66501691
76bile acid metabolic process (GO:0008206)3.66309088
77cytochrome complex assembly (GO:0017004)3.64239788
78coenzyme catabolic process (GO:0009109)3.61902535
79alpha-amino acid catabolic process (GO:1901606)3.61692488
80respiratory electron transport chain (GO:0022904)3.59814686
81cellular ketone body metabolic process (GO:0046950)3.59480594
82electron transport chain (GO:0022900)3.59147223
83aromatic amino acid family metabolic process (GO:0009072)3.58647343
84regulation of protein activation cascade (GO:2000257)3.57948736
85acylglycerol homeostasis (GO:0055090)3.53866849
86triglyceride homeostasis (GO:0070328)3.53866849
87axoneme assembly (GO:0035082)3.52871286
88sperm capacitation (GO:0048240)3.51275310
89plasma lipoprotein particle clearance (GO:0034381)3.50066929
90aspartate family amino acid catabolic process (GO:0009068)3.49792278
91fatty acid beta-oxidation (GO:0006635)3.49591126
92ketone body metabolic process (GO:1902224)3.48537938
93benzene-containing compound metabolic process (GO:0042537)3.47727406
94homocysteine metabolic process (GO:0050667)3.46429321
95phospholipid efflux (GO:0033700)3.40583436
96fatty acid catabolic process (GO:0009062)3.39644987
97ubiquinone metabolic process (GO:0006743)3.39011571
98monocarboxylic acid catabolic process (GO:0072329)3.38664240
99cellular amino acid catabolic process (GO:0009063)3.38057291
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37207942
101tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37207942
102drug catabolic process (GO:0042737)3.37061557
103aldehyde catabolic process (GO:0046185)3.36608010
104arginine metabolic process (GO:0006525)3.36552589
105platelet dense granule organization (GO:0060155)3.35543073
106peptidyl-histidine modification (GO:0018202)3.35533679
107carnitine transport (GO:0015879)3.34268720
108amino-acid betaine transport (GO:0015838)3.34268720
109quinone biosynthetic process (GO:1901663)3.33338818
110negative regulation of lipase activity (GO:0060192)3.32958115
111cofactor catabolic process (GO:0051187)3.32624453
112fatty acid oxidation (GO:0019395)3.32332424
113amine catabolic process (GO:0009310)3.32133517
114cellular biogenic amine catabolic process (GO:0042402)3.32133517
115regulation of complement activation (GO:0030449)3.31400122
116cilium or flagellum-dependent cell motility (GO:0001539)3.31038763
117flavonoid metabolic process (GO:0009812)3.30692095
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.30643643
119xenobiotic catabolic process (GO:0042178)3.30637866
120short-chain fatty acid metabolic process (GO:0046459)3.28654722
121negative regulation of inclusion body assembly (GO:0090084)3.28217742
122lipid oxidation (GO:0034440)3.28166834
123organic acid catabolic process (GO:0016054)3.25115923
124carboxylic acid catabolic process (GO:0046395)3.25115923
125chaperone-mediated protein transport (GO:0072321)3.25028234
126GTP biosynthetic process (GO:0006183)3.24495795
127protein polyglutamylation (GO:0018095)3.24031292
128negative regulation of cholesterol transport (GO:0032375)3.23869574
129negative regulation of sterol transport (GO:0032372)3.23869574
130single fertilization (GO:0007338)3.22964495
131mannosylation (GO:0097502)3.22128662
132phenylpropanoid metabolic process (GO:0009698)3.20716042
133carnitine transmembrane transport (GO:1902603)3.19061785
134pyrimidine nucleobase catabolic process (GO:0006208)3.14794696
135regulation of mitochondrial translation (GO:0070129)3.12941124
136quinone metabolic process (GO:1901661)3.11123089
137base-excision repair, AP site formation (GO:0006285)3.10058187
138branched-chain amino acid catabolic process (GO:0009083)3.01922476
139preassembly of GPI anchor in ER membrane (GO:0016254)3.00534058
140arginine catabolic process (GO:0006527)2.99136437
141C-terminal protein lipidation (GO:0006501)2.91830641
142L-methionine salvage (GO:0071267)2.90557789
143L-methionine biosynthetic process (GO:0071265)2.90557789
144amino acid salvage (GO:0043102)2.90557789
145exogenous drug catabolic process (GO:0042738)2.87840204
146behavioral response to nicotine (GO:0035095)2.87095379
147establishment of protein localization to mitochondrial membrane (GO:0090151)2.86154937
148cullin deneddylation (GO:0010388)2.83693225
149purine nucleoside triphosphate biosynthetic process (GO:0009145)2.82744954
150purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.80927344
151proteasome assembly (GO:0043248)2.78900841
152pyrimidine nucleotide catabolic process (GO:0006244)2.78298236
153hydrogen ion transmembrane transport (GO:1902600)2.76060232
154L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73703990
155nucleobase catabolic process (GO:0046113)2.71357521
156phenol-containing compound catabolic process (GO:0019336)2.69287738
157C4-dicarboxylate transport (GO:0015740)2.69000263
158DNA deamination (GO:0045006)2.68896960
159proton transport (GO:0015992)2.68123007
160positive regulation of mitochondrial fission (GO:0090141)2.67226852
161ATP biosynthetic process (GO:0006754)2.67168886
162protein deneddylation (GO:0000338)2.65815643
163hydrogen transport (GO:0006818)2.63741776
164vitamin biosynthetic process (GO:0009110)2.63175259
165anterograde synaptic vesicle transport (GO:0048490)2.62866634
166glycine metabolic process (GO:0006544)2.62228879
167C-terminal protein amino acid modification (GO:0018410)2.61176352
168ethanol oxidation (GO:0006069)2.60362985
169UTP metabolic process (GO:0046051)2.60255388
170branched-chain amino acid metabolic process (GO:0009081)2.59904892
171replication fork processing (GO:0031297)2.59234662
172serine family amino acid metabolic process (GO:0009069)2.59033221
173regulation of glucokinase activity (GO:0033131)2.56678071
174regulation of hexokinase activity (GO:1903299)2.56678071
175epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.55980656
176deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55763965
177indolalkylamine metabolic process (GO:0006586)2.55684573
178UTP biosynthetic process (GO:0006228)2.55625209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.64173598
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.30364021
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.01286163
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.69234446
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.41621524
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.37922897
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.11441684
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.94059376
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.93483442
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58476461
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.44812183
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.29576390
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.26763264
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.22404708
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09302519
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.97511247
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.50606084
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.44462864
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.43964491
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31622550
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24182340
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19320023
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15104236
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14390712
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11374604
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94768233
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85432062
28VDR_23849224_ChIP-Seq_CD4+_Human1.84307452
29GABP_19822575_ChIP-Seq_HepG2_Human1.72827233
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67739127
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66705372
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63145014
33IGF1R_20145208_ChIP-Seq_DFB_Human1.62869968
34VDR_22108803_ChIP-Seq_LS180_Human1.62837064
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61128484
36GBX2_23144817_ChIP-Seq_PC3_Human1.60495352
37MYC_18940864_ChIP-ChIP_HL60_Human1.59220985
38TP53_22573176_ChIP-Seq_HFKS_Human1.54772362
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52226005
40FOXP3_21729870_ChIP-Seq_TREG_Human1.51010425
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48693085
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48654443
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48088334
44PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46341018
45ELK1_19687146_ChIP-ChIP_HELA_Human1.44778708
46RXRA_24833708_ChIP-Seq_LIVER_Mouse1.40705371
47RAD21_21589869_ChIP-Seq_MESCs_Mouse1.40623320
48SOX2_22085726_ChIP-Seq_NPCs_Mouse1.37253674
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.35827286
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35736821
51STAT1_17558387_ChIP-Seq_HELA_Human1.35576367
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.34918988
53NCOR_22424771_ChIP-Seq_293T_Human1.34636103
54IRF1_19129219_ChIP-ChIP_H3396_Human1.33616757
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31885013
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29796996
57TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29642730
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27567891
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.27567891
60EZH2_22144423_ChIP-Seq_EOC_Human1.25239684
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23702593
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23504164
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21817813
64* ERA_21632823_ChIP-Seq_H3396_Human1.21806846
65ERG_20517297_ChIP-Seq_VCAP_Human1.21277618
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18462291
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17836054
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17135665
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16355656
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15417981
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15249419
72* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14589397
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14384444
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13283820
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12548896
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12091880
77DCP1A_22483619_ChIP-Seq_HELA_Human1.11410179
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.10340335
79HTT_18923047_ChIP-ChIP_STHdh_Human1.09470518
80* P53_21459846_ChIP-Seq_SAOS-2_Human1.09277411
81TAF15_26573619_Chip-Seq_HEK293_Human1.07622176
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07484410
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07477934
84ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07184662
85GATA3_21867929_ChIP-Seq_CD8_Mouse1.06992877
86MYC_19829295_ChIP-Seq_ESCs_Human1.05654867
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05246844
88TAF2_19829295_ChIP-Seq_ESCs_Human1.05172517
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02994070
90AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02762100
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02263395
92PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02172389
93ESET_19884257_ChIP-Seq_ESCs_Mouse1.01008314
94MYC_27129775_Chip-Seq_CORNEA_Mouse1.00936496
95E2F1_20622854_ChIP-Seq_HELA_Human0.99722076
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99350030
97EWS_26573619_Chip-Seq_HEK293_Human0.97954947
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.97632916
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97522320
100SOX2_21211035_ChIP-Seq_LN229_Human0.97512560
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97485328
102HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97238970
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96747804
104P300_27268052_Chip-Seq_Bcells_Human0.96347732
105* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95607436
106KDM2B_26808549_Chip-Seq_REH_Human0.95424743
107TAL1_26923725_Chip-Seq_HPCs_Mouse0.95310966
108LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.95124123
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94951337
110FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94901349
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94617988
112CBP_20019798_ChIP-Seq_JUKART_Human0.94617988
113ZNF274_21170338_ChIP-Seq_K562_Hela0.94466863
114RARA_24833708_ChIP-Seq_LIVER_Mouse0.94138412
115STAT1_20625510_ChIP-Seq_HELA_Human0.92870226
116SOX2_19829295_ChIP-Seq_ESCs_Human0.92606051
117NANOG_19829295_ChIP-Seq_ESCs_Human0.92606051
118* P300_19829295_ChIP-Seq_ESCs_Human0.92552215
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.92357798
120CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92332462
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91997828
122SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91536540
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91535370
124SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91286609
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90963725
126CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90049532
127TET1_21451524_ChIP-Seq_MESCs_Mouse0.89995298
128EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89410049
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88979210
130FOXP1_21924763_ChIP-Seq_HESCs_Human0.88927857
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.87736845
132* FOXA2_19822575_ChIP-Seq_HepG2_Human0.87452677
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87394191
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86307628
135NANOG_20526341_ChIP-Seq_ESCs_Human0.85865223
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85094862
137CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84718085
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.84117801
139* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84041082
140GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.83417421
141FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82724636
142ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82232377
143GATA3_21867929_ChIP-Seq_TH1_Mouse0.81962164
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.79860731
145TBX20_22080862_ChIP-Seq_HEART_Mouse0.79860731
146GF1_26923725_Chip-Seq_HPCs_Mouse0.79621678
147CTCF_20526341_ChIP-Seq_ESCs_Human0.78743188
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78635931
149RARB_24833708_ChIP-Seq_LIVER_Mouse0.77998092
150SOX11_22085726_ChIP-Seq_ESNs_Mouse0.77836560
151CTCF_27219007_Chip-Seq_Bcells_Human0.77460024
152* HNF4A_19822575_ChIP-Seq_HepG2_Human0.77025405
153CRX_20693478_ChIP-Seq_RETINA_Mouse0.76880924
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.76639111
155THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75221575
156SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75177663
157BCOR_27268052_Chip-Seq_Bcells_Human0.74688735
158OCT4_20526341_ChIP-Seq_ESCs_Human0.74639471
159BCAT_22108803_ChIP-Seq_LS180_Human0.73425907
160ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73209964
161NFE2_27457419_Chip-Seq_LIVER_Mouse0.73160155
162FLI1_21867929_ChIP-Seq_TH2_Mouse0.73157731
163SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73130956
164LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.72702617
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72426712
166JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72032993
167PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71883396
168AR_20517297_ChIP-Seq_VCAP_Human0.71832405
169TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71229334
170BCL6_27268052_Chip-Seq_Bcells_Human0.70451396
171* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70437054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.88526526
2MP0002139_abnormal_hepatobiliary_system6.75246843
3MP0005360_urolithiasis6.04515326
4MP0005085_abnormal_gallbladder_physiolo5.12474959
5MP0005365_abnormal_bile_salt5.02556817
6MP0008875_abnormal_xenobiotic_pharmacok4.61145920
7MP0003806_abnormal_nucleotide_metabolis3.52290530
8MP0010329_abnormal_lipoprotein_level3.04028598
9MP0005670_abnormal_white_adipose2.80205079
10MP0003252_abnormal_bile_duct2.75128510
11MP0005332_abnormal_amino_acid2.61233792
12MP0009840_abnormal_foam_cell2.52614572
13MP0003195_calcinosis2.33383041
14MP0005083_abnormal_biliary_tract2.29457552
15MP0003698_abnormal_male_reproductive2.11387809
16MP0004019_abnormal_vitamin_homeostasis2.06163524
17MP0003787_abnormal_imprinting2.05928597
18MP0002837_dystrophic_cardiac_calcinosis2.05084726
19MP0008877_abnormal_DNA_methylation2.03018942
20MP0002118_abnormal_lipid_homeostasis1.83882599
21MP0003718_maternal_effect1.82395434
22MP0001929_abnormal_gametogenesis1.82287333
23MP0005551_abnormal_eye_electrophysiolog1.81992587
24MP0001666_abnormal_nutrient_absorption1.78999164
25MP0001764_abnormal_homeostasis1.75886435
26MP0001529_abnormal_vocalization1.75241272
27MP0006072_abnormal_retinal_apoptosis1.74781658
28MP0003122_maternal_imprinting1.73250282
29MP0005319_abnormal_enzyme/_coenzyme1.71057867
30MP0004133_heterotaxia1.69558314
31MP0000609_abnormal_liver_physiology1.60800361
32MP0009697_abnormal_copulation1.60317961
33MP0003011_delayed_dark_adaptation1.60219515
34MP0003191_abnormal_cellular_cholesterol1.59335286
35MP0002736_abnormal_nociception_after1.55431722
36MP0006036_abnormal_mitochondrial_physio1.55101333
37MP0002163_abnormal_gland_morphology1.54258697
38MP0002102_abnormal_ear_morphology1.53838211
39MP0002638_abnormal_pupillary_reflex1.52115762
40MP0005253_abnormal_eye_physiology1.47637286
41MP0003121_genomic_imprinting1.47113656
42MP0001968_abnormal_touch/_nociception1.44309895
43MP0006276_abnormal_autonomic_nervous1.42184750
44MP0009046_muscle_twitch1.42099006
45MP0006292_abnormal_olfactory_placode1.40959922
46MP0005451_abnormal_body_composition1.40025937
47MP0005645_abnormal_hypothalamus_physiol1.39291756
48MP0005584_abnormal_enzyme/coenzyme_acti1.39215625
49MP0008789_abnormal_olfactory_epithelium1.38714131
50MP0000372_irregular_coat_pigmentation1.37689239
51MP0003646_muscle_fatigue1.36530013
52MP0008058_abnormal_DNA_repair1.35926368
53MP0002090_abnormal_vision1.35342479
54MP0002938_white_spotting1.35016418
55MP0005379_endocrine/exocrine_gland_phen1.34573668
56MP0003186_abnormal_redox_activity1.33573547
57MP0001905_abnormal_dopamine_level1.30981182
58MP0005646_abnormal_pituitary_gland1.30911691
59MP0002254_reproductive_system_inflammat1.29528534
60MP0000569_abnormal_digit_pigmentation1.23909737
61MP0009643_abnormal_urine_homeostasis1.20971303
62MP0005647_abnormal_sex_gland1.19834168
63MP0008872_abnormal_physiological_respon1.18973747
64MP0002161_abnormal_fertility/fecundity1.15807564
65MP0009745_abnormal_behavioral_response1.15604133
66MP0001984_abnormal_olfaction1.15517731
67MP0003786_premature_aging1.13928678
68MP0005636_abnormal_mineral_homeostasis1.13064973
69MP0004147_increased_porphyrin_level1.12084619
70MP0002822_catalepsy1.11680989
71MP0003868_abnormal_feces_composition1.11430256
72MP0002138_abnormal_hepatobiliary_system1.08934071
73MP0004742_abnormal_vestibular_system1.04456029
74MP0003880_abnormal_central_pattern1.04235586
75MP0005499_abnormal_olfactory_system1.03880573
76MP0005394_taste/olfaction_phenotype1.03880573
77MP0002733_abnormal_thermal_nociception1.02959904
78MP0010368_abnormal_lymphatic_system1.02255332
79MP0005423_abnormal_somatic_nervous1.02246276
80MP0002557_abnormal_social/conspecific_i1.00231014
81MP0005084_abnormal_gallbladder_morpholo0.99899396
82MP0005075_abnormal_melanosome_morpholog0.99751762
83MP0004142_abnormal_muscle_tone0.98161820
84MP0002971_abnormal_brown_adipose0.94707191
85MP0004233_abnormal_muscle_weight0.94617976
86MP0004130_abnormal_muscle_cell0.93581959
87MP0010386_abnormal_urinary_bladder0.90921080
88MP0002909_abnormal_adrenal_gland0.90680136
89MP0002272_abnormal_nervous_system0.90668811
90MP0001970_abnormal_pain_threshold0.87796683
91MP0009384_cardiac_valve_regurgitation0.86418878
92MP0005220_abnormal_exocrine_pancreas0.85678136
93MP0005666_abnormal_adipose_tissue0.85075408
94MP0001324_abnormal_eye_pigmentation0.83852930
95MP0002572_abnormal_emotion/affect_behav0.82883224
96MP0005376_homeostasis/metabolism_phenot0.82383339
97MP0004036_abnormal_muscle_relaxation0.81896842
98MP0003279_aneurysm0.81849492
99MP0005535_abnormal_body_temperature0.81685146
100MP0000598_abnormal_liver_morphology0.81049833
101MP0002735_abnormal_chemical_nociception0.80733384
102MP0003705_abnormal_hypodermis_morpholog0.80298206
103MP0000631_abnormal_neuroendocrine_gland0.78991692
104MP0002229_neurodegeneration0.77290981
105MP0009764_decreased_sensitivity_to0.77260522
106MP0006035_abnormal_mitochondrial_morpho0.76651990
107MP0005174_abnormal_tail_pigmentation0.76526686
108MP0005195_abnormal_posterior_eye0.75926121
109MP0002210_abnormal_sex_determination0.75450123
110MP0002078_abnormal_glucose_homeostasis0.74749935
111MP0009642_abnormal_blood_homeostasis0.73766591
112MP0008775_abnormal_heart_ventricle0.73368715
113MP0005266_abnormal_metabolism0.72656568
114MP0005334_abnormal_fat_pad0.72010130
115MP0005448_abnormal_energy_balance0.71539147
116MP0002876_abnormal_thyroid_physiology0.71347654
117MP0001756_abnormal_urination0.70792174
118MP0009115_abnormal_fat_cell0.70423816
119MP0002168_other_aberrant_phenotype0.69720989
120MP0002064_seizures0.69682466
121MP0001485_abnormal_pinna_reflex0.69575368
122MP0009763_increased_sensitivity_to0.66804942
123MP0001765_abnormal_ion_homeostasis0.66060490
124MP0005330_cardiomyopathy0.65855901
125MP0000604_amyloidosis0.64728719
126MP0001145_abnormal_male_reproductive0.64239696
127MP0002282_abnormal_trachea_morphology0.63047012
128MP0000653_abnormal_sex_gland0.62171821
129MP0002160_abnormal_reproductive_system0.61800134
130MP0000230_abnormal_systemic_arterial0.61220296
131MP0005408_hypopigmentation0.60511855
132MP0002269_muscular_atrophy0.57666310
133MP0003329_amyloid_beta_deposits0.56472177
134MP0002295_abnormal_pulmonary_circulatio0.55382507
135MP0002928_abnormal_bile_duct0.55111713
136MP0005395_other_phenotype0.54817804
137MP0003656_abnormal_erythrocyte_physiolo0.54609206
138MP0008469_abnormal_protein_level0.54563605
139MP0001661_extended_life_span0.51482781
140MP0004084_abnormal_cardiac_muscle0.51140992
141MP0000751_myopathy0.48744016
142MP0008438_abnormal_cutaneous_collagen0.48362028
143MP0005503_abnormal_tendon_morphology0.48192489
144MP0003953_abnormal_hormone_level0.47764697
145MP0002653_abnormal_ependyma_morphology0.47375934
146MP0004043_abnormal_pH_regulation0.46678048
147MP0000538_abnormal_urinary_bladder0.46343725
148MP0010030_abnormal_orbit_morphology0.45874428
149MP0005385_cardiovascular_system_phenoty0.45672285
150MP0001544_abnormal_cardiovascular_syste0.45672285
151MP0006138_congestive_heart_failure0.45296678
152MP0004782_abnormal_surfactant_physiolog0.44577382
153MP0000749_muscle_degeneration0.43875389
154MP0000639_abnormal_adrenal_gland0.43764768
155MP0002136_abnormal_kidney_physiology0.42538138
156MP0009053_abnormal_anal_canal0.42189772
157MP0000249_abnormal_blood_vessel0.40801322
158MP0005377_hearing/vestibular/ear_phenot0.39707037

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.77795723
2Absent/shortened dynein arms (HP:0200106)6.44518955
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.44518955
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.46513950
5Abnormal respiratory motile cilium physiology (HP:0012261)5.38836306
6Deep venous thrombosis (HP:0002625)4.95411160
7Abnormal respiratory motile cilium morphology (HP:0005938)4.87264373
8Abnormal respiratory epithelium morphology (HP:0012253)4.87264373
9Prolonged partial thromboplastin time (HP:0003645)4.59557803
10Intrahepatic cholestasis (HP:0001406)4.56189635
11Xanthomatosis (HP:0000991)4.50521772
12Abnormal ciliary motility (HP:0012262)4.39717595
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.24876961
14Rhinitis (HP:0012384)4.24754079
15Hypobetalipoproteinemia (HP:0003563)4.19301360
16Hyperlipoproteinemia (HP:0010980)4.12733558
17Ketosis (HP:0001946)4.10957517
18Mitochondrial inheritance (HP:0001427)3.96563333
19Chronic bronchitis (HP:0004469)3.81997727
20Progressive macrocephaly (HP:0004481)3.76333728
21Hepatocellular necrosis (HP:0001404)3.70781019
22Infertility (HP:0000789)3.70138609
23Hyperammonemia (HP:0001987)3.56124235
24Increased CSF lactate (HP:0002490)3.54246106
25Hypolipoproteinemia (HP:0010981)3.51794406
26Pancreatic fibrosis (HP:0100732)3.47827432
27Hypoalphalipoproteinemia (HP:0003233)3.45757731
28Hyperglycinuria (HP:0003108)3.42835269
29Hypercholesterolemia (HP:0003124)3.36091492
30Pancreatic cysts (HP:0001737)3.35546361
31Hypoglycemic coma (HP:0001325)3.29674366
32Abnormality of fatty-acid metabolism (HP:0004359)3.27620008
33Complement deficiency (HP:0004431)3.26469089
34Molar tooth sign on MRI (HP:0002419)3.26151902
35Abnormality of midbrain morphology (HP:0002418)3.26151902
36Hyperglycinemia (HP:0002154)3.23377184
37Medial flaring of the eyebrow (HP:0010747)3.19630613
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.17361061
39Abnormality of serine family amino acid metabolism (HP:0010894)3.17277539
40Abnormality of glycine metabolism (HP:0010895)3.17277539
41Joint hemorrhage (HP:0005261)3.16341379
42Abnormality of glutamine family amino acid metabolism (HP:0010902)3.13855466
43Ketoacidosis (HP:0001993)3.13783467
44Abnormality of aspartate family amino acid metabolism (HP:0010899)3.06318074
45Epidermoid cyst (HP:0200040)3.05619032
46True hermaphroditism (HP:0010459)2.99462606
47Cerebral edema (HP:0002181)2.98320372
48Nasal polyposis (HP:0100582)2.97978871
49Cholecystitis (HP:0001082)2.97368864
50Abnormal gallbladder physiology (HP:0012438)2.97368864
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.94896027
52Dicarboxylic aciduria (HP:0003215)2.92648742
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.92648742
543-Methylglutaconic aciduria (HP:0003535)2.92637008
55Abnormality of methionine metabolism (HP:0010901)2.92131080
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.84028539
57Lactic acidosis (HP:0003128)2.74217907
58Renal Fanconi syndrome (HP:0001994)2.70993051
59Gait imbalance (HP:0002141)2.68104317
60Abnormality of the common coagulation pathway (HP:0010990)2.65088550
61Increased serum lactate (HP:0002151)2.64964296
62Lethargy (HP:0001254)2.63393766
63Fat malabsorption (HP:0002630)2.59711096
64Abnormal rod and cone electroretinograms (HP:0008323)2.58206417
65Generalized aminoaciduria (HP:0002909)2.57960814
66Congenital stationary night blindness (HP:0007642)2.56222991
67Congenital primary aphakia (HP:0007707)2.55025512
68Polyphagia (HP:0002591)2.54393732
69Potter facies (HP:0002009)2.53196096
70Facial shape deformation (HP:0011334)2.53196096
71Abnormal number of erythroid precursors (HP:0012131)2.52745276
72Abnormality of the nasal mucosa (HP:0000433)2.51734781
73Abnormality of the intrinsic pathway (HP:0010989)2.49133491
74Lipid accumulation in hepatocytes (HP:0006561)2.48830729
75Vascular calcification (HP:0004934)2.48310029
76Respiratory failure (HP:0002878)2.47914060
77Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47278397
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47278397
79Optic disc pallor (HP:0000543)2.46994645
80Sclerocornea (HP:0000647)2.44527071
81Gout (HP:0001997)2.42903884
82Abnormality of complement system (HP:0005339)2.41313739
83Metabolic acidosis (HP:0001942)2.40913351
84Nephrogenic diabetes insipidus (HP:0009806)2.40318492
85Myoglobinuria (HP:0002913)2.39744960
86Acute encephalopathy (HP:0006846)2.37161166
87Increased hepatocellular lipid droplets (HP:0006565)2.36869038
88Hyperbilirubinemia (HP:0002904)2.36324842
89Male infertility (HP:0003251)2.35185480
90Cystic liver disease (HP:0006706)2.35164435
91Abnormality of purine metabolism (HP:0004352)2.33763923
92Cardiovascular calcification (HP:0011915)2.28103565
93Conjugated hyperbilirubinemia (HP:0002908)2.26972211
94Abnormality of nucleobase metabolism (HP:0010932)2.23679752
95Exercise intolerance (HP:0003546)2.22287255
96Methylmalonic acidemia (HP:0002912)2.22031149
97Increased serum pyruvate (HP:0003542)2.19890385
98Increased intramyocellular lipid droplets (HP:0012240)2.19515781
99Spontaneous abortion (HP:0005268)2.18317324
100Severe visual impairment (HP:0001141)2.17434292
101Enlarged kidneys (HP:0000105)2.17396616
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14206748
103Hepatic necrosis (HP:0002605)2.13938478
104Abnormality of the renal medulla (HP:0100957)2.13869188
105Renal cortical cysts (HP:0000803)2.13489096
106Vomiting (HP:0002013)2.13017165
107Bronchiectasis (HP:0002110)2.12935536
108Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12582504
109Delayed CNS myelination (HP:0002188)2.12356899
110Abnormal protein glycosylation (HP:0012346)2.10375119
111Abnormal glycosylation (HP:0012345)2.10375119
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10375119
113Abnormal protein N-linked glycosylation (HP:0012347)2.10375119
114Malnutrition (HP:0004395)2.09555835
115Increased muscle lipid content (HP:0009058)2.07787483
116Abnormality of cells of the erythroid lineage (HP:0012130)2.07585426
117Abnormality of serum amino acid levels (HP:0003112)2.07345240
118Decreased central vision (HP:0007663)2.06407244
119Hemorrhage of the eye (HP:0011885)2.06154776
120Proximal tubulopathy (HP:0000114)2.04217485
121Abnormality of urine glucose concentration (HP:0011016)2.04040700
122Glycosuria (HP:0003076)2.04040700
123Abnormality of pyrimidine metabolism (HP:0004353)2.03511411
124Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01327783
125Acute necrotizing encephalopathy (HP:0006965)2.00087292
126CNS demyelination (HP:0007305)1.98678095
127Attenuation of retinal blood vessels (HP:0007843)1.98304314
128Hyperalaninemia (HP:0003348)1.98055691
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98055691
130Abnormality of alanine metabolism (HP:0010916)1.98055691
131Abnormal gallbladder morphology (HP:0012437)1.96802053
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.96313939
133Type I transferrin isoform profile (HP:0003642)1.95318643
134Postaxial foot polydactyly (HP:0001830)1.95260532
135Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95227558
136Cholelithiasis (HP:0001081)1.94170389
137Rhabdomyolysis (HP:0003201)1.94009597
138Steatorrhea (HP:0002570)1.92203788
139Tubulointerstitial nephritis (HP:0001970)1.91875454
140Abnormality of glycolysis (HP:0004366)1.91780490
141Late onset (HP:0003584)1.90967933
142Aplasia/hypoplasia of the uterus (HP:0008684)1.90170092
143Congenital hepatic fibrosis (HP:0002612)1.89761969
144Brushfield spots (HP:0001088)1.89595012
145Bronchitis (HP:0012387)1.89248786
146Abnormality of renal resorption (HP:0011038)1.88059084
147Abnormality of the anterior horn cell (HP:0006802)1.87749440
148Degeneration of anterior horn cells (HP:0002398)1.87749440
149Abnormal mitochondria in muscle tissue (HP:0008316)1.87700230
150Chronic hepatic failure (HP:0100626)1.87454580
151Methylmalonic aciduria (HP:0012120)1.87389352
152Hypothermia (HP:0002045)1.86726986
153Genital tract atresia (HP:0001827)1.86515702
154Hepatocellular carcinoma (HP:0001402)1.86132796
155Pancreatitis (HP:0001733)1.86116468
156Anencephaly (HP:0002323)1.85081064
157Increased purine levels (HP:0004368)1.84726325
158Hyperuricemia (HP:0002149)1.84726325
159Abolished electroretinogram (ERG) (HP:0000550)1.84106597
160Palpitations (HP:0001962)1.82857615
161Bile duct proliferation (HP:0001408)1.80677254
162Abnormal biliary tract physiology (HP:0012439)1.80677254
163Recurrent sinusitis (HP:0011108)1.78713671
164Nephronophthisis (HP:0000090)1.78292334
165Abnormality of the renal cortex (HP:0011035)1.78187889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.64780198
2PDK36.64780198
3TESK15.01011955
4PDK24.18158070
5MAP4K24.02553822
6BCKDK3.87125669
7VRK23.30324193
8ICK3.07501631
9PRKD32.89834410
10ERN12.47701949
11WNK42.37063083
12NUAK12.34102031
13MAPK152.27263275
14TLK12.24447734
15ZAK2.09186040
16MYLK2.07256010
17SIK11.87909237
18DYRK1B1.87708530
19PTK2B1.86228341
20CSNK1G31.84385795
21STK391.81874679
22INSRR1.70947958
23PIK3CG1.63088985
24LIMK11.63063750
25CASK1.60871740
26CSNK1G21.58497974
27VRK11.56865009
28FGFR41.56859949
29STK38L1.54547230
30PINK11.48273028
31TRIM281.46813441
32CSNK1G11.46138256
33MUSK1.44008607
34BMPR1B1.41413917
35CSNK1A1L1.36693105
36MST41.29108696
37MAPK131.28819428
38STK381.28479397
39MST1R1.28236087
40MAP3K41.26757849
41BUB11.23423544
42BCR1.20669380
43TIE11.19248806
44NME21.17085751
45ERBB41.13846994
46LMTK21.11309845
47DAPK11.10669604
48PLK41.08433037
49NME11.07690132
50OXSR11.07480041
51TRIB31.04821272
52EPHA31.03568103
53MAP2K61.02791195
54IKBKB0.90457831
55MAP2K40.89808568
56FER0.88691070
57TXK0.85958444
58PLK30.84409469
59IRAK10.81022414
60SRPK10.80513013
61PLK20.78912793
62MARK10.78080066
63TGFBR10.77153171
64PDPK10.75138872
65PDK10.75076100
66MAPK110.73634467
67PRKCE0.72359752
68PRKCI0.70793567
69NEK90.69454548
70CSNK1A10.68822250
71TNIK0.68314501
72ACVR1B0.68285889
73STK160.67560233
74DYRK30.66030943
75EPHB20.62319418
76ADRBK10.61832697
77TAF10.61469537
78TAOK20.61320953
79MAPKAPK50.61305255
80MINK10.60878414
81KDR0.59257820
82MAPK120.58518837
83CDK190.58163171
84RPS6KA50.57502790
85OBSCN0.56968688
86MAPK40.55524530
87MAP3K120.55417267
88MAP3K110.55411333
89PLK10.54800151
90PAK30.54314696
91MAP2K20.53648526
92PBK0.52501905
93ABL20.51362039
94TTN0.49568956
95PRKAA20.49387449
96PRKCZ0.48436331
97CAMK2G0.48062701
98WNK30.47121326
99ERBB30.47118563
100TBK10.45939041
101PRKACG0.45580306
102PRKG20.43230198
103PRKCG0.42608428
104IRAK20.41594783
105PHKG20.41210794
106PHKG10.41210794
107FLT30.37805586
108CDK80.37739082
109CSNK2A10.37583279
110PRKAA10.36275879
111NEK10.35344904
112LATS10.35215780
113CSNK2A20.35053925
114EPHB10.32328924
115DAPK20.32014394
116TESK20.31710919
117MAP3K50.31586766
118MAP2K10.31508402
119ADRBK20.30475217
120TAOK30.29652413
121IGF1R0.28794808
122DAPK30.28366138
123PIK3CA0.28259282
124MAPK70.27865208
125PKN20.27749751
126FRK0.27317128
127CHEK20.26709983
128PRKACA0.26556540
129CAMK2A0.26050062
130AURKA0.25725806
131PRKCQ0.24618010
132PTK60.23462713
133TYK20.23051402
134MET0.22892309
135GRK50.22777482
136MAP3K10.22604272
137STK30.22604247
138BMPR20.20992481
139PRKCA0.20131513
140WNK10.20020605
141GRK10.19953608
142DYRK20.19221170
143GRK70.17524244
144GSK3A0.16871970
145ARAF0.16488021
146CAMK2D0.15188083
147PRKG10.14094070
148MAP3K30.13432691
149MAPKAPK30.13025649
150PRKCD0.12724550
151MAP2K70.12158316
152LATS20.12130393
153PIM20.12020827

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.35389282
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30487241
3Propanoate metabolism_Homo sapiens_hsa006402.82010991
4Fatty acid degradation_Homo sapiens_hsa000712.80361642
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75495753
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.62911272
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59509794
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53182934
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.52446602
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.33348042
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30161381
12Chemical carcinogenesis_Homo sapiens_hsa052042.24776553
13Fatty acid metabolism_Homo sapiens_hsa012122.22186184
14Pyruvate metabolism_Homo sapiens_hsa006202.19310525
15PPAR signaling pathway_Homo sapiens_hsa033202.14867703
16Tryptophan metabolism_Homo sapiens_hsa003802.13529325
17Arginine biosynthesis_Homo sapiens_hsa002202.11515789
18Butanoate metabolism_Homo sapiens_hsa006502.07527693
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06638842
20Nitrogen metabolism_Homo sapiens_hsa009102.05610215
21Peroxisome_Homo sapiens_hsa041462.04175028
22Complement and coagulation cascades_Homo sapiens_hsa046101.97238179
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93752218
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.88337741
25Protein export_Homo sapiens_hsa030601.88282016
26Sulfur metabolism_Homo sapiens_hsa009201.80826554
27Proteasome_Homo sapiens_hsa030501.74546831
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68725769
29Retinol metabolism_Homo sapiens_hsa008301.68091807
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.63116402
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61466231
32beta-Alanine metabolism_Homo sapiens_hsa004101.54402249
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52182008
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51860344
35Carbon metabolism_Homo sapiens_hsa012001.51179959
36Histidine metabolism_Homo sapiens_hsa003401.47635119
37Fatty acid elongation_Homo sapiens_hsa000621.46440221
38Fatty acid biosynthesis_Homo sapiens_hsa000611.45970952
39Starch and sucrose metabolism_Homo sapiens_hsa005001.45716065
40RNA polymerase_Homo sapiens_hsa030201.42448981
41Phenylalanine metabolism_Homo sapiens_hsa003601.42264490
42Selenocompound metabolism_Homo sapiens_hsa004501.42069051
43Bile secretion_Homo sapiens_hsa049761.38437543
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36622237
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35335030
46Fat digestion and absorption_Homo sapiens_hsa049751.32707701
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29715093
48Tyrosine metabolism_Homo sapiens_hsa003501.21639301
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.20792995
50Caffeine metabolism_Homo sapiens_hsa002321.18269938
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12496568
52Vitamin B6 metabolism_Homo sapiens_hsa007501.10875527
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09707610
54Glutathione metabolism_Homo sapiens_hsa004801.09327800
55Base excision repair_Homo sapiens_hsa034101.07061449
56Biosynthesis of amino acids_Homo sapiens_hsa012301.05933861
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04063482
58Oxidative phosphorylation_Homo sapiens_hsa001901.03951310
59Steroid biosynthesis_Homo sapiens_hsa001001.03777724
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02783189
61Ribosome_Homo sapiens_hsa030101.02386436
62Phototransduction_Homo sapiens_hsa047441.01342262
63Glycerolipid metabolism_Homo sapiens_hsa005610.99605233
64Linoleic acid metabolism_Homo sapiens_hsa005910.98782082
65ABC transporters_Homo sapiens_hsa020100.96075633
66Staphylococcus aureus infection_Homo sapiens_hsa051500.95680712
67Pyrimidine metabolism_Homo sapiens_hsa002400.93213794
68Arginine and proline metabolism_Homo sapiens_hsa003300.90324661
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89377350
70Sulfur relay system_Homo sapiens_hsa041220.87427421
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84581624
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.80086559
73Homologous recombination_Homo sapiens_hsa034400.79171090
74Parkinsons disease_Homo sapiens_hsa050120.77497200
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77445832
76One carbon pool by folate_Homo sapiens_hsa006700.76841372
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75822955
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74546195
79Vitamin digestion and absorption_Homo sapiens_hsa049770.72605804
80Fructose and mannose metabolism_Homo sapiens_hsa000510.71388905
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67965240
82Folate biosynthesis_Homo sapiens_hsa007900.67839080
83Metabolic pathways_Homo sapiens_hsa011000.66936898
84Fanconi anemia pathway_Homo sapiens_hsa034600.66017882
85Regulation of autophagy_Homo sapiens_hsa041400.62325200
86Huntingtons disease_Homo sapiens_hsa050160.61762507
87Mismatch repair_Homo sapiens_hsa034300.61069097
88Glucagon signaling pathway_Homo sapiens_hsa049220.61031838
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.55676288
90Non-homologous end-joining_Homo sapiens_hsa034500.54547780
91Alzheimers disease_Homo sapiens_hsa050100.54282326
92Pentose phosphate pathway_Homo sapiens_hsa000300.52933449
93Cardiac muscle contraction_Homo sapiens_hsa042600.50910977
94Galactose metabolism_Homo sapiens_hsa000520.49862381
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.49796100
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46520768
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42039612
98Nucleotide excision repair_Homo sapiens_hsa034200.40354229
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39037526
100Basal transcription factors_Homo sapiens_hsa030220.37272676
101DNA replication_Homo sapiens_hsa030300.36561631
102Arachidonic acid metabolism_Homo sapiens_hsa005900.36491340
103Lysine degradation_Homo sapiens_hsa003100.36235575
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.31551166
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30568154
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27709048
107Ether lipid metabolism_Homo sapiens_hsa005650.22346358
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20882140
109Insulin resistance_Homo sapiens_hsa049310.19014361
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15876014
111Renin-angiotensin system_Homo sapiens_hsa046140.12203240
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.11006733
113Mineral absorption_Homo sapiens_hsa049780.10322196
114Collecting duct acid secretion_Homo sapiens_hsa049660.07187560
115AMPK signaling pathway_Homo sapiens_hsa041520.03374441
116Ovarian steroidogenesis_Homo sapiens_hsa049130.00785865
117Thyroid hormone synthesis_Homo sapiens_hsa049180.00575853
118Insulin signaling pathway_Homo sapiens_hsa04910-0.1478722
119Purine metabolism_Homo sapiens_hsa00230-0.0697602
120Prion diseases_Homo sapiens_hsa05020-0.0639002
121Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0314887
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0300864
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0082654
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0046165

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