TMEM54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)7.84929287
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.64410399
3regulation of water loss via skin (GO:0033561)7.56307241
4intestinal absorption (GO:0050892)7.08169930
5keratinization (GO:0031424)5.90567939
6intestinal epithelial cell development (GO:0060576)5.76191396
7maintenance of gastrointestinal epithelium (GO:0030277)5.59872212
8calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.48761945
9multicellular organismal water homeostasis (GO:0050891)5.45867164
10negative regulation of keratinocyte proliferation (GO:0010839)5.34248168
11angiotensin maturation (GO:0002003)5.22889429
12positive regulation of pseudopodium assembly (GO:0031274)5.07003768
13intestinal cholesterol absorption (GO:0030299)5.06343445
14bile acid and bile salt transport (GO:0015721)5.01589941
15keratinocyte proliferation (GO:0043616)4.90305929
16regulation of guanylate cyclase activity (GO:0031282)4.84173533
17NADH metabolic process (GO:0006734)4.79079593
18hemidesmosome assembly (GO:0031581)4.74598371
19intermediate filament organization (GO:0045109)4.71932351
20sphingoid metabolic process (GO:0046519)4.71837203
21keratinocyte development (GO:0003334)4.65030368
22positive regulation of respiratory burst (GO:0060267)4.56831593
23digestive system process (GO:0022600)4.54990449
24diol metabolic process (GO:0034311)4.50877025
25epithelial structure maintenance (GO:0010669)4.50196378
26regulation of pseudopodium assembly (GO:0031272)4.49091109
27water homeostasis (GO:0030104)4.48391860
28hair cycle (GO:0042633)4.43449178
29molting cycle (GO:0042303)4.43449178
30GDP-mannose metabolic process (GO:0019673)4.43220776
31purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.40705490
323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.40705490
33phosphatidylinositol acyl-chain remodeling (GO:0036149)4.37158426
34phosphatidylserine acyl-chain remodeling (GO:0036150)4.22212974
35sulfate transmembrane transport (GO:1902358)4.07290313
36actin filament depolymerization (GO:0030042)4.04917504
37renal filtration (GO:0097205)4.04584451
38regulation of transforming growth factor beta1 production (GO:0032908)4.00799693
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.99404243
40primary alcohol catabolic process (GO:0034310)3.97930779
41keratinocyte differentiation (GO:0030216)3.97254316
42renal system process involved in regulation of blood volume (GO:0001977)3.96692684
43glomerular filtration (GO:0003094)3.90621846
44ventricular cardiac muscle cell action potential (GO:0086005)3.88530327
45antibacterial humoral response (GO:0019731)3.88377364
46vitamin A metabolic process (GO:0006776)3.88005187
47regulation of keratinocyte proliferation (GO:0010837)3.86784017
48O-glycan processing (GO:0016266)3.86165476
49COPI coating of Golgi vesicle (GO:0048205)3.79860317
50Golgi transport vesicle coating (GO:0048200)3.79860317
51hepatocyte apoptotic process (GO:0097284)3.79058137
52phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.76458433
53antimicrobial humoral response (GO:0019730)3.75744759
54regulation of respiratory burst (GO:0060263)3.69103769
55protein retention in ER lumen (GO:0006621)3.68753041
56nucleoside diphosphate biosynthetic process (GO:0009133)3.68267204
57phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.64634013
58regulation of ruffle assembly (GO:1900027)3.62844911
59adhesion of symbiont to host cell (GO:0044650)3.62684286
60virion attachment to host cell (GO:0019062)3.62684286
61sulfation (GO:0051923)3.60328389
62flavonoid metabolic process (GO:0009812)3.57716521
63ATP synthesis coupled proton transport (GO:0015986)3.56569542
64energy coupled proton transport, down electrochemical gradient (GO:0015985)3.56569542
65regulation of cellular extravasation (GO:0002691)3.53650440
66positive regulation of epidermal cell differentiation (GO:0045606)3.52597836
67regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.51965098
68phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.50661154
69pyrimidine-containing compound transmembrane transport (GO:0072531)3.48669344
70ethanol metabolic process (GO:0006067)3.46787831
71epithelial cell-cell adhesion (GO:0090136)3.45334142
72epidermal cell differentiation (GO:0009913)3.45273845
73lung secretory cell differentiation (GO:0061140)3.44919028
74phospholipid scrambling (GO:0017121)3.44770570
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44546166
76oligosaccharide biosynthetic process (GO:0009312)3.43654279
77sphingosine metabolic process (GO:0006670)3.43255581
78regulation of systemic arterial blood pressure by hormone (GO:0001990)3.42625323
79regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.42625323
80endocrine process (GO:0050886)3.42625323
81negative regulation of protein tyrosine kinase activity (GO:0061099)3.42503101
82positive regulation of guanylate cyclase activity (GO:0031284)3.42485832
83regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.40791317
84regulation of cholesterol homeostasis (GO:2000188)3.40674757
85regulation of vitamin metabolic process (GO:0030656)3.38389559
86regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.37144842
87urea cycle (GO:0000050)3.36475525
88cellular glucuronidation (GO:0052695)3.36365600
89UDP-N-acetylglucosamine metabolic process (GO:0006047)3.34771969
90glomerular visceral epithelial cell development (GO:0072015)3.31500289
91glucuronate metabolic process (GO:0019585)3.31065396
92uronic acid metabolic process (GO:0006063)3.31065396
93sulfate transport (GO:0008272)3.29957882
94transepithelial transport (GO:0070633)3.26984481
95regulation of chemokine secretion (GO:0090196)3.25925632
96mucosal immune response (GO:0002385)3.25708726
97tight junction assembly (GO:0070830)3.25469399
98negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.24934734
99regulation of systemic arterial blood pressure (GO:0003073)3.24652431
100digestion (GO:0007586)3.22772215
101positive regulation of epidermis development (GO:0045684)3.20881859
102branching involved in mammary gland duct morphogenesis (GO:0060444)3.20672185
103positive regulation of interleukin-8 secretion (GO:2000484)3.20631448
104phosphatidylserine metabolic process (GO:0006658)3.20319319
105negative regulation of epidermal cell differentiation (GO:0045605)3.18337142
106fructose metabolic process (GO:0006000)3.18178055
107renal absorption (GO:0070293)3.17965161
108proline biosynthetic process (GO:0006561)3.16966086
109cell communication involved in cardiac conduction (GO:0086065)3.14899103
110positive regulation of glycoprotein metabolic process (GO:1903020)3.10877326
111sulfur compound transport (GO:0072348)3.07718889
112regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.07114217
113glutathione biosynthetic process (GO:0006750)3.06904947
114urea metabolic process (GO:0019627)3.06627946
115regulation of apoptotic process involved in morphogenesis (GO:1902337)3.06578664
116organ or tissue specific immune response (GO:0002251)3.04605841
117modified amino acid transport (GO:0072337)3.04028976
118intermediate filament cytoskeleton organization (GO:0045104)3.01966477
119innate immune response in mucosa (GO:0002227)3.01365260
120positive regulation of glycoprotein biosynthetic process (GO:0010560)3.01141839
121activation of Rac GTPase activity (GO:0032863)3.01007582
122regulation of heart rate by cardiac conduction (GO:0086091)3.00297074
123negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99083485
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.98779439
125cardiac conduction (GO:0061337)2.98024342
126positive regulation of fatty acid beta-oxidation (GO:0032000)2.97804263
127sphingomyelin metabolic process (GO:0006684)2.97637735
128nucleotide-sugar biosynthetic process (GO:0009226)2.97541246
129epidermis development (GO:0008544)2.93750432
130intermediate filament-based process (GO:0045103)2.93583254
131regulation of actin nucleation (GO:0051125)2.93276832
132phospholipid efflux (GO:0033700)2.92272540
133glutamine family amino acid biosynthetic process (GO:0009084)2.91999840
134epoxygenase P450 pathway (GO:0019373)2.87415146
135fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.86148671
136regulation of cGMP biosynthetic process (GO:0030826)2.84812881
137glandular epithelial cell differentiation (GO:0002067)2.84723034
138phosphatidylcholine acyl-chain remodeling (GO:0036151)2.83742469
139glomerular epithelial cell development (GO:0072310)2.83664740
140cytidine deamination (GO:0009972)2.80108000
141cytidine metabolic process (GO:0046087)2.80108000
142cytidine catabolic process (GO:0006216)2.80108000
143nonribosomal peptide biosynthetic process (GO:0019184)2.79955762
144adhesion of symbiont to host (GO:0044406)2.79874118
145regulation of viral release from host cell (GO:1902186)2.77701486
146peptide cross-linking (GO:0018149)2.76454078
147nitrogen cycle metabolic process (GO:0071941)2.76400917
148regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75200598
149fat-soluble vitamin biosynthetic process (GO:0042362)2.75060163
150glycosphingolipid catabolic process (GO:0046479)2.74320921
151gap junction assembly (GO:0016264)2.73838251
152renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.73203965
153auditory receptor cell differentiation (GO:0042491)2.71849326
154receptor guanylyl cyclase signaling pathway (GO:0007168)2.71846181
155retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.71673362
156eosinophil chemotaxis (GO:0048245)2.69930297
157cellular response to pH (GO:0071467)2.69782207
158ethanol oxidation (GO:0006069)2.69647553
159glucocorticoid biosynthetic process (GO:0006704)2.65863741
160regulation of extracellular matrix disassembly (GO:0010715)2.64120429
161glycolipid catabolic process (GO:0019377)2.63833232
162regulation of early endosome to late endosome transport (GO:2000641)2.63755101
163negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.63019868
164myelin maintenance (GO:0043217)2.61415584
165regulation of cholesterol metabolic process (GO:0090181)2.60937756
166cyclooxygenase pathway (GO:0019371)2.58258750
167sulfur amino acid catabolic process (GO:0000098)2.56611173
168regulation of bile acid biosynthetic process (GO:0070857)2.55810141
169desmosome organization (GO:0002934)10.2100464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.45624749
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.07560819
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.25655424
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.02729954
5SRY_22984422_ChIP-ChIP_TESTIS_Rat2.99474721
6* SOX2_20726797_ChIP-Seq_SW620_Human2.76946223
7GATA4_25053715_ChIP-Seq_YYC3_Human2.65698547
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.58724691
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.49270134
10GATA6_25053715_ChIP-Seq_YYC3_Human2.48191597
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.27861084
12TCF4_18268006_ChIP-ChIP_LS174T_Human2.08025394
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.06621906
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03577453
15* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.03365016
16TP63_17297297_ChIP-ChIP_HaCaT_Human12.5067542
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98181689
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.93224202
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89925905
20KLF5_25053715_ChIP-Seq_YYC3_Human1.88038943
21ZNF263_19887448_ChIP-Seq_K562_Human1.87549001
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.85085402
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80541929
24* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80185785
25* RXR_22158963_ChIP-Seq_LIVER_Mouse1.79032021
26VDR_22108803_ChIP-Seq_LS180_Human1.78030336
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.75365513
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.75051390
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74688065
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.71016175
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64680656
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63142919
33ATF3_27146783_Chip-Seq_COLON_Human1.60784373
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56062838
35RACK7_27058665_Chip-Seq_MCF-7_Human1.55771326
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55733262
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53872113
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53872113
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53065634
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51925385
41CLOCK_20551151_ChIP-Seq_293T_Human1.51071079
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.48919004
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47844245
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45198516
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45016425
46* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43923551
47* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43757610
48BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.40414088
49CREB1_26743006_Chip-Seq_LNCaP_Human1.35325238
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33374905
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33312436
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32352067
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31176199
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.30802097
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29790647
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29614588
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29284027
58* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28086985
59P68_20966046_ChIP-Seq_HELA_Human1.27324283
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26605319
61VDR_21846776_ChIP-Seq_THP-1_Human1.26225983
62SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25683421
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23448956
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20419443
65TP63_22573176_ChIP-Seq_HFKS_Human1.20341745
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19758785
67BCOR_27268052_Chip-Seq_Bcells_Human1.18911813
68SMC4_20622854_ChIP-Seq_HELA_Human1.18153033
69* CTCF_27219007_Chip-Seq_Bcells_Human1.17037801
70* KDM2B_26808549_Chip-Seq_K562_Human1.16704295
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16190744
72GATA3_24758297_ChIP-Seq_MCF-7_Human1.15892243
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15794603
74* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15277204
75BCAT_22108803_ChIP-Seq_LS180_Human1.13025647
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12848043
77* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12477226
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12406662
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11098274
80* SA1_27219007_Chip-Seq_Bcells_Human1.10441660
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10394389
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10327671
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10208187
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09820720
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08647387
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07952545
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07712619
88* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07121574
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06715455
90* LXR_22158963_ChIP-Seq_LIVER_Mouse1.05784250
91BCL6_27268052_Chip-Seq_Bcells_Human1.04697924
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03856115
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03513685
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02017473
95* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01544557
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00804897
97LXR_22292898_ChIP-Seq_THP-1_Human1.00142020
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99957615
99* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99671747
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97783672
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97071422
102TCF7_22412390_ChIP-Seq_EML_Mouse0.95706509
103* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94922196
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94235349
105SA1_27219007_Chip-Seq_ERYTHROID_Human0.93122373
106FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92551275
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92440753
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92030472
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91920827
110ETS1_21867929_ChIP-Seq_TH2_Mouse0.91512366
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89331201
112NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89282836
113FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88139825
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87899654
115SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87676430
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87119566
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86354388
118ELF5_23300383_ChIP-Seq_T47D_Human0.85583685
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84579848
120IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84237637
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83835177
122* NANOG_20526341_ChIP-Seq_ESCs_Human0.83758358
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83439495
124JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82695250
125CEBPB_22108803_ChIP-Seq_LS180_Human0.82142158
126* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81903141
127AR_21909140_ChIP-Seq_LNCAP_Human0.81448169
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81447860
129AHR_22903824_ChIP-Seq_MCF-7_Human0.80927011
130JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.80719927
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80201991
132TP63_23658742_ChIP-Seq_EP156T_Human0.79127900
133TAF2_19829295_ChIP-Seq_ESCs_Human0.79035809
134* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78599516
135ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.78184618
136* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77271299
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76577913
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.75406960
139* EZH2_27294783_Chip-Seq_ESCs_Mouse0.75348664
140MYC_19829295_ChIP-Seq_ESCs_Human0.75205478
141FOXA1_25552417_ChIP-Seq_VCAP_Human0.74746893
142* CTCF_20526341_ChIP-Seq_ESCs_Human0.74135045
143FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73937161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle9.48105433
2MP0002796_impaired_skin_barrier5.28365384
3MP0005360_urolithiasis3.43592487
4MP0005501_abnormal_skin_physiology3.27270303
5MP0001666_abnormal_nutrient_absorption3.11787274
6MP0004264_abnormal_extraembryonic_tissu3.00674251
7MP0003941_abnormal_skin_development2.90747215
8MP0010678_abnormal_skin_adnexa2.79472401
9MP0000462_abnormal_digestive_system2.77616067
10MP0005451_abnormal_body_composition2.58480718
11MP0002098_abnormal_vibrissa_morphology2.54473049
12MP0005275_abnormal_skin_tensile2.52343832
13MP0002822_catalepsy2.49908708
14MP0008004_abnormal_stomach_pH2.48058726
15MP0000537_abnormal_urethra_morphology2.42481735
16MP0009379_abnormal_foot_pigmentation2.36055218
17MP0003866_abnormal_defecation2.26839140
18MP0001873_stomach_inflammation2.25482052
19MP0004858_abnormal_nervous_system2.21171537
20MP0001216_abnormal_epidermal_layer2.18514708
21MP0005409_darkened_coat_color2.16484762
22MP0000579_abnormal_nail_morphology2.03935093
23MP0001664_abnormal_digestion2.02529141
24MP0003315_abnormal_perineum_morphology1.99505845
25MP0001663_abnormal_digestive_system1.98380543
26MP0003878_abnormal_ear_physiology1.97431529
27MP0005377_hearing/vestibular/ear_phenot1.97431529
28MP0003283_abnormal_digestive_organ1.96435070
29MP0010352_gastrointestinal_tract_polyps1.95958266
30MP0010771_integument_phenotype1.93325517
31MP0005381_digestive/alimentary_phenotyp1.93050866
32MP0003453_abnormal_keratinocyte_physiol1.79209747
33MP0004947_skin_inflammation1.78704812
34MP0005365_abnormal_bile_salt1.78607332
35MP0003705_abnormal_hypodermis_morpholog1.77240556
36MP0000383_abnormal_hair_follicle1.73311147
37MP0002254_reproductive_system_inflammat1.70236734
38MP0000477_abnormal_intestine_morphology1.68556282
39MP0002060_abnormal_skin_morphology1.68032093
40MP0000490_abnormal_crypts_of1.67400906
41MP0000467_abnormal_esophagus_morphology1.62706487
42MP0010155_abnormal_intestine_physiology1.62316327
43MP0005058_abnormal_lysosome_morphology1.58114154
44MP0000377_abnormal_hair_follicle1.57412068
45MP0008875_abnormal_xenobiotic_pharmacok1.55744802
46MP0004019_abnormal_vitamin_homeostasis1.44417670
47MP0009780_abnormal_chondrocyte_physiolo1.40760394
48MP0003191_abnormal_cellular_cholesterol1.37351191
49MP0000427_abnormal_hair_cycle1.35752079
50MP0003183_abnormal_peptide_metabolism1.34176716
51MP0005166_decreased_susceptibility_to1.33857916
52MP0005257_abnormal_intraocular_pressure1.29932914
53MP0005085_abnormal_gallbladder_physiolo1.25538686
54MP0000762_abnormal_tongue_morphology1.24627663
55MP0000647_abnormal_sebaceous_gland1.20060993
56MP0003879_abnormal_hair_cell1.18109304
57MP0000538_abnormal_urinary_bladder1.17993776
58MP0005670_abnormal_white_adipose1.15288712
59MP0005023_abnormal_wound_healing1.13516940
60MP0002234_abnormal_pharynx_morphology1.11184552
61MP0009053_abnormal_anal_canal1.07047903
62MP0001756_abnormal_urination1.06481484
63MP0009931_abnormal_skin_appearance1.06476519
64MP0000470_abnormal_stomach_morphology1.05493098
65MP0002277_abnormal_respiratory_mucosa1.01070083
66MP0003806_abnormal_nucleotide_metabolis1.01055985
67MP0001765_abnormal_ion_homeostasis1.00803556
68MP0002896_abnormal_bone_mineralization1.00552115
69MP0005666_abnormal_adipose_tissue1.00165945
70MP0004381_abnormal_hair_follicle0.98042551
71MP0003329_amyloid_beta_deposits0.95395236
72MP0004043_abnormal_pH_regulation0.93713602
73MP0010030_abnormal_orbit_morphology0.93541158
74MP0001191_abnormal_skin_condition0.93039982
75MP0004185_abnormal_adipocyte_glucose0.91554858
76MP0001881_abnormal_mammary_gland0.89655093
77MP0001849_ear_inflammation0.88663450
78MP0005167_abnormal_blood-brain_barrier0.88241749
79MP0006054_spinal_hemorrhage0.87887303
80MP0000566_synostosis0.87786309
81MP0008260_abnormal_autophagy0.85790990
82MP0005332_abnormal_amino_acid0.85504972
83MP0000003_abnormal_adipose_tissue0.84767653
84MP0003252_abnormal_bile_duct0.83195510
85MP0002138_abnormal_hepatobiliary_system0.81943134
86MP0000627_abnormal_mammary_gland0.81406193
87MP0010386_abnormal_urinary_bladder0.80922691
88MP0004272_abnormal_basement_membrane0.80324193
89MP0004147_increased_porphyrin_level0.79745563
90MP0005367_renal/urinary_system_phenotyp0.78880609
91MP0000516_abnormal_urinary_system0.78880609
92MP0005375_adipose_tissue_phenotype0.78837766
93MP0004270_analgesia0.78378051
94MP0000681_abnormal_thyroid_gland0.77635496
95MP0009643_abnormal_urine_homeostasis0.73568385
96MP0003566_abnormal_cell_adhesion0.73291547
97MP0000367_abnormal_coat/_hair0.72858482
98MP0010329_abnormal_lipoprotein_level0.72702275
99MP0009840_abnormal_foam_cell0.72508206
100MP0000678_abnormal_parathyroid_gland0.72185187
101MP0002249_abnormal_larynx_morphology0.70084351
102MP0002118_abnormal_lipid_homeostasis0.68905983
103MP0002089_abnormal_postnatal_growth/wei0.68689764
104MP0000858_altered_metastatic_potential0.67895208
105MP0001346_abnormal_lacrimal_gland0.67388036
106MP0002876_abnormal_thyroid_physiology0.64670424
107MP0000613_abnormal_salivary_gland0.63569263
108MP0003075_altered_response_to0.63031578
109MP0001188_hyperpigmentation0.61845415
110MP0002877_abnormal_melanocyte_morpholog0.61569325
111MP0005319_abnormal_enzyme/_coenzyme0.61229679
112MP0002909_abnormal_adrenal_gland0.59043870
113MP0002009_preneoplasia0.58305230
114MP0004484_altered_response_of0.58102456
115MP0005636_abnormal_mineral_homeostasis0.58094825
116MP0002166_altered_tumor_susceptibility0.58066868
117MP0008872_abnormal_physiological_respon0.57971739
118MP0005187_abnormal_penis_morphology0.54545898
119MP0005310_abnormal_salivary_gland0.52346579
120MP0004782_abnormal_surfactant_physiolog0.52276743
121MP0001501_abnormal_sleep_pattern0.49915106
122MP0003868_abnormal_feces_composition0.49711779
123MP0002132_abnormal_respiratory_system0.48518075
124MP0003300_gastrointestinal_ulcer0.48454014
125MP0005165_increased_susceptibility_to0.47861941
126MP0001243_abnormal_dermal_layer0.47840242
127MP0003693_abnormal_embryo_hatching0.47338441
128MP0003123_paternal_imprinting0.46852690
129MP0002163_abnormal_gland_morphology0.46187245
130MP0002136_abnormal_kidney_physiology0.46040877
131MP0005076_abnormal_cell_differentiation0.44101419
132MP0008789_abnormal_olfactory_epithelium0.43993776
133MP0003119_abnormal_digestive_system0.43776261
134MP0002139_abnormal_hepatobiliary_system0.43291635

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.42224877
2Woolly hair (HP:0002224)6.15874895
3Congenital ichthyosiform erythroderma (HP:0007431)5.80639545
4Ileus (HP:0002595)5.51845596
5Pili torti (HP:0003777)5.15213373
6Fragile nails (HP:0001808)5.10132845
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.42541979
8Increased IgE level (HP:0003212)4.41337652
9Onycholysis (HP:0001806)4.24992072
10Abnormality of small intestinal villus morphology (HP:0011472)4.03447445
11Villous atrophy (HP:0011473)4.03447445
12Plantar hyperkeratosis (HP:0007556)3.99181784
13Malnutrition (HP:0004395)3.94438037
14Curly hair (HP:0002212)3.86374276
15Decreased circulating renin level (HP:0003351)3.82867949
16Hyperactive renin-angiotensin system (HP:0000841)3.78150689
17Hypotrichosis (HP:0001006)3.73117011
18Abdominal distention (HP:0003270)3.70271476
19Flat acetabular roof (HP:0003180)3.52755048
20Abnormality of nail color (HP:0100643)3.45027277
21Ventricular fibrillation (HP:0001663)3.39854869
22Milia (HP:0001056)3.33333571
23Cupped ribs (HP:0000887)3.24126101
24Alkalosis (HP:0001948)3.22947691
25Palmoplantar hyperkeratosis (HP:0000972)3.21475677
26Abnormality of monocarboxylic acid metabolism (HP:0010996)3.19149033
27Symphalangism affecting the phalanges of the hand (HP:0009773)3.17275210
28Dehydration (HP:0001944)3.16824495
29Biliary tract neoplasm (HP:0100574)3.12122660
30Corneal erosion (HP:0200020)3.08432072
31Abnormality of the 1st metacarpal (HP:0010009)3.04064674
32Palmar hyperkeratosis (HP:0010765)2.98786688
33Mesangial abnormality (HP:0001966)2.93977730
34Thin bony cortex (HP:0002753)2.92259299
35Abnormal hair laboratory examination (HP:0003328)2.91025220
36Rectal prolapse (HP:0002035)2.89210690
37Nail dystrophy (HP:0008404)2.86542948
38Abnormality of chloride homeostasis (HP:0011422)2.83893468
39Systemic lupus erythematosus (HP:0002725)2.76314269
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.75445620
41Ridged nail (HP:0001807)2.70881917
42Syncope (HP:0001279)2.70298587
43Hemorrhage of the eye (HP:0011885)2.69907730
44Conjunctival hamartoma (HP:0100780)2.66674734
45Abnormal blistering of the skin (HP:0008066)2.66299217
46Parakeratosis (HP:0001036)2.64801820
47Abnormality of the distal phalanx of the thumb (HP:0009617)2.57904368
48Abnormality of the gastric mucosa (HP:0004295)2.55460462
49Growth hormone excess (HP:0000845)2.53507582
50Hyperaldosteronism (HP:0000859)2.49721624
51Ventricular tachycardia (HP:0004756)2.49492971
52Hypoalbuminemia (HP:0003073)2.41598999
53Abnormal albumin level (HP:0012116)2.41598999
54Abnormal biliary tract morphology (HP:0012440)2.38882452
55Metabolic alkalosis (HP:0200114)2.38346856
56Upper limb amyotrophy (HP:0009129)2.37212650
57Distal upper limb amyotrophy (HP:0007149)2.37212650
58Axonal loss (HP:0003447)2.37206274
59Hoarse voice (HP:0001609)2.35482079
60Flattened epiphyses (HP:0003071)2.34463082
61Pterygium (HP:0001059)2.33322645
62Erythroderma (HP:0001019)2.31148264
63Abnormality of the 2nd finger (HP:0004100)2.30464613
64Hyponatremia (HP:0002902)2.30449413
65Spinal cord compression (HP:0002176)2.30101537
66Sparse eyelashes (HP:0000653)2.29146433
67Fat malabsorption (HP:0002630)2.29044770
68Conjugated hyperbilirubinemia (HP:0002908)2.27942037
69Erythema (HP:0010783)2.27906980
70Abnormality of the distal phalanges of the toes (HP:0010182)2.26780001
71Down-sloping shoulders (HP:0200021)2.26636135
72Pustule (HP:0200039)2.26123569
73Micronodular cirrhosis (HP:0001413)2.24804924
74Focal segmental glomerulosclerosis (HP:0000097)2.22502691
75Hyperphosphatemia (HP:0002905)2.22351551
76Neonatal short-limb short stature (HP:0008921)2.21411211
77Congenital sensorineural hearing impairment (HP:0008527)2.20377005
78Palmoplantar keratoderma (HP:0000982)2.18720998
79Distal lower limb muscle weakness (HP:0009053)2.15573590
80Palpitations (HP:0001962)2.15345654
81Lip pit (HP:0100267)2.15152178
82Short phalanx of the thumb (HP:0009660)2.14724203
83Intrahepatic cholestasis (HP:0001406)2.13449658
84Renal tubular acidosis (HP:0001947)2.13204270
85Hyperphosphaturia (HP:0003109)2.13127052
86Absent phalangeal crease (HP:0006109)2.11067545
87Atrophic scars (HP:0001075)2.10386331
88Mildly elevated creatine phosphokinase (HP:0008180)2.10048745
89Concave nail (HP:0001598)2.10023813
90Abnormality of carpal bone ossification (HP:0006257)2.09412242
91Glomerulosclerosis (HP:0000096)2.08636804
92Ectropion (HP:0000656)2.05375833
93Hypotension (HP:0002615)2.05094916
94Widely patent fontanelles and sutures (HP:0004492)2.04184918
95Hypohidrosis (HP:0000966)2.04166372
96Hyperparathyroidism (HP:0000843)2.03382962
97Myopathic facies (HP:0002058)2.02997227
98Stridor (HP:0010307)2.02348458
99Congenital, generalized hypertrichosis (HP:0004540)2.01811650
100Chronic diarrhea (HP:0002028)2.01674032
101Glycosuria (HP:0003076)2.00978366
102Abnormality of urine glucose concentration (HP:0011016)2.00978366
103Vertebral compression fractures (HP:0002953)1.99687039
104Pruritus (HP:0000989)1.99653463
105Cervical subluxation (HP:0003308)1.99573485
106Acanthosis nigricans (HP:0000956)1.98811826
107Osteolytic defects of the hand bones (HP:0009699)1.96955789
108Osteolytic defects of the phalanges of the hand (HP:0009771)1.96955789
109Bone pain (HP:0002653)1.96498916
110Multiple lipomas (HP:0001012)1.96303481
111Abnormality of the middle phalanges of the toes (HP:0010183)1.96048613
112Vascular calcification (HP:0004934)1.95871619
113Distal lower limb amyotrophy (HP:0008944)1.95428926
114Abnormal tarsal ossification (HP:0008369)1.94942111
115Neoplasm of the rectum (HP:0100743)1.94862775
116Late onset (HP:0003584)1.93885746
117Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.93173240
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92094984
119Congenital malformation of the right heart (HP:0011723)1.91625623
120Double outlet right ventricle (HP:0001719)1.91625623
121Abnormality of the vitamin B12 metabolism (HP:0004341)1.90057532
122Subcapsular cataract (HP:0000523)1.89843006
123Hypokinesia (HP:0002375)1.88837928
124Alopecia of scalp (HP:0002293)1.88598424
125Hyperammonemia (HP:0001987)1.88212032
126Hydroxyprolinuria (HP:0003080)1.88187457
127Abnormality of proline metabolism (HP:0010907)1.88187457
128Abnormal hemoglobin (HP:0011902)1.85902739
129Esophageal atresia (HP:0002032)1.85049032
130Gout (HP:0001997)1.84994063
131Abnormal urine phosphate concentration (HP:0012599)1.84983641
132Achilles tendon contracture (HP:0001771)1.84539834
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84292423
134Abnormality of complement system (HP:0005339)1.81954100
135Wide cranial sutures (HP:0010537)1.80540668
136Protuberant abdomen (HP:0001538)1.80325556
137Abnormality of the Achilles tendon (HP:0005109)1.79766454
138Posterior subcapsular cataract (HP:0007787)1.79677818
139Amelogenesis imperfecta (HP:0000705)1.79369756
140Increased purine levels (HP:0004368)1.79104551
141Hyperuricemia (HP:0002149)1.79104551
142Abnormal ossification of hand bones (HP:0005921)1.78980519
143Brittle hair (HP:0002299)1.78871740
144Abnormality of renin-angiotensin system (HP:0000847)1.77644925
145Hypophosphatemia (HP:0002148)1.77641458
146Macrocytic anemia (HP:0001972)1.77281204
147Abnormality of the nasal mucosa (HP:0000433)1.76898702
148Adrenal overactivity (HP:0002717)1.76882485
149Fragile skin (HP:0001030)1.74683286
150Progressive sensorineural hearing impairment (HP:0000408)1.74429442
151J-shaped sella turcica (HP:0002680)1.73954524
152Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.73270966
153Confusion (HP:0001289)1.73129534
154Nephrolithiasis (HP:0000787)1.73063922
155Cardiovascular calcification (HP:0011915)1.72858888
156Neonatal onset (HP:0003623)1.72554761
157Abnormality of sodium homeostasis (HP:0010931)1.72233394
158Hypokalemia (HP:0002900)1.71968313

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.18722753
2MST45.12866197
3NME14.36315986
4FRK4.28875764
5EPHB23.70556758
6LMTK23.52673164
7TRIB33.18121622
8PIK3CA3.15654802
9MAP2K22.93596630
10IRAK32.81486731
11MAP3K122.76461572
12SIK12.60599203
13MAP3K22.30434520
14TAOK32.23221079
15FER2.21813943
16EPHA22.19822989
17MAP3K112.18775925
18RIPK12.08593740
19RIPK42.01470982
20MAPKAPK31.94760866
21GRK61.89700293
22RPS6KB21.89677863
23TAOK11.88449091
24SMG11.87226043
25TESK11.79345646
26PRKG21.76559837
27MAP2K61.76091578
28ACVR1B1.67003990
29TESK21.54513912
30MYLK1.51717970
31MAP3K31.40921392
32MET1.40885382
33PRKCI1.35418657
34PKN21.26199094
35PTK61.23258200
36ICK1.22303844
37MAP2K11.21014646
38CASK1.18466214
39FGFR41.15604084
40KSR21.12284451
41PTK21.10520227
42EPHB11.08947066
43EPHA41.06653113
44CAMK2D1.04602748
45PRKD31.02722265
46PRPF4B1.01165804
47MAP3K91.00769248
48STK100.98566923
49TTK0.96405407
50DDR20.95864408
51CAMK2B0.92499587
52LATS10.92201064
53BRAF0.89826209
54MAP3K10.89405350
55ABL20.88508862
56MAP3K70.87790194
57EEF2K0.85869303
58STK390.81322599
59PBK0.80292415
60PAK40.80234903
61PDGFRA0.80097118
62WNK40.79325293
63IRAK20.79082786
64BMX0.77642317
65CDC42BPA0.77537308
66PRKD20.71923021
67CDK190.71620395
68STK38L0.69101719
69AKT30.67195197
70MAP3K80.65919630
71LIMK10.65033957
72ERBB40.64239973
73SCYL20.64214700
74PIM20.62397028
75TBK10.59569753
76CAMK2G0.58772819
77BLK0.58577403
78OXSR10.55727733
79ERN10.55674716
80ARAF0.55446040
81NME20.53093024
82NUAK10.52817711
83TLK10.52615014
84MAP3K100.52472868
85RPS6KA20.51259338
86ERBB20.50864639
87AURKB0.49883814
88LRRK20.48486272
89BCR0.48139493
90GRK10.48064759
91IRAK10.44636956
92MUSK0.44357955
93PRKCA0.41795254
94PAK10.40865546
95STK380.40471910
96DAPK10.39027589
97STK110.38601819
98STK240.37986170
99FGFR10.37686682
100MAP2K40.37565508
101NTRK10.36940709
102MAPKAPK20.36487688
103MAP3K60.35685806
104CSNK1E0.34265470
105SRC0.33327904
106MTOR0.31837797
107TAOK20.30713435
108PHKG10.28489849
109PHKG20.28489849
110PDK10.26594917
111IRAK40.26454641
112ROCK10.26156690
113DAPK30.25588430
114MATK0.25244003
115DMPK0.25189440
116CAMK2A0.24664064
117RET0.23396915
118TYK20.23127459
119CSNK1A10.23025590
120ILK0.22304886
121MAP2K30.21782645
122PDK20.20911687
123YES10.20685433
124PDPK10.19799134
125FGFR30.19753328
126PRKCE0.19614206
127NEK60.19005191
128AKT20.18888412
129ADRBK10.18496233
130ROCK20.18214602
131MAPK110.13279343
132LATS20.12810130
133MINK10.12231953
134PAK30.10828054
135BMPR20.10396158
136FGR0.09934946
137PRKACA0.09487349
138GRK50.09481358
139PRKAA20.07923244

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.78253339
2Sulfur metabolism_Homo sapiens_hsa009204.70542629
3Mineral absorption_Homo sapiens_hsa049783.80163071
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64265945
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.60402535
6Linoleic acid metabolism_Homo sapiens_hsa005912.57224354
7Renin-angiotensin system_Homo sapiens_hsa046142.53173469
8Arginine biosynthesis_Homo sapiens_hsa002202.53059437
9Oxidative phosphorylation_Homo sapiens_hsa001902.36681092
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.35062007
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.18628653
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.05136433
13Histidine metabolism_Homo sapiens_hsa003402.00764872
14Arachidonic acid metabolism_Homo sapiens_hsa005902.00694123
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84645544
16Alzheimers disease_Homo sapiens_hsa050101.76516001
17Vitamin digestion and absorption_Homo sapiens_hsa049771.75440129
18Bile secretion_Homo sapiens_hsa049761.70307884
19Sphingolipid metabolism_Homo sapiens_hsa006001.69925391
20Parkinsons disease_Homo sapiens_hsa050121.69173425
21Other glycan degradation_Homo sapiens_hsa005111.68239452
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66353685
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.63556657
24Tight junction_Homo sapiens_hsa045301.61936552
25Glutathione metabolism_Homo sapiens_hsa004801.61252671
26Fructose and mannose metabolism_Homo sapiens_hsa000511.60015410
27Galactose metabolism_Homo sapiens_hsa000521.56632674
28Pancreatic secretion_Homo sapiens_hsa049721.54186017
29Protein digestion and absorption_Homo sapiens_hsa049741.53680452
30Sulfur relay system_Homo sapiens_hsa041221.53596837
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52743138
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48869670
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45532808
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43756830
35Ribosome_Homo sapiens_hsa030101.42754854
36Ether lipid metabolism_Homo sapiens_hsa005651.28134749
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.19461706
38Nitrogen metabolism_Homo sapiens_hsa009101.18728136
39Folate biosynthesis_Homo sapiens_hsa007901.17491557
40Gastric acid secretion_Homo sapiens_hsa049711.17255143
41Glycerolipid metabolism_Homo sapiens_hsa005611.16449571
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15944405
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15667335
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15290624
45Huntingtons disease_Homo sapiens_hsa050161.10097735
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09564773
47Chemical carcinogenesis_Homo sapiens_hsa052041.04132435
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04002626
49Salivary secretion_Homo sapiens_hsa049701.01597543
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00248651
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99486750
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96668202
53Cardiac muscle contraction_Homo sapiens_hsa042600.94626417
54Vibrio cholerae infection_Homo sapiens_hsa051100.87637485
55Bladder cancer_Homo sapiens_hsa052190.84965392
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.83828720
57Starch and sucrose metabolism_Homo sapiens_hsa005000.83639113
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82557367
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.79230230
60Thyroid cancer_Homo sapiens_hsa052160.77821271
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76666521
62Retinol metabolism_Homo sapiens_hsa008300.69290327
63GnRH signaling pathway_Homo sapiens_hsa049120.68273718
64Biosynthesis of amino acids_Homo sapiens_hsa012300.67723447
65Tyrosine metabolism_Homo sapiens_hsa003500.66162366
66Vitamin B6 metabolism_Homo sapiens_hsa007500.65740686
67Hepatitis C_Homo sapiens_hsa051600.65413050
68Renin secretion_Homo sapiens_hsa049240.64806823
69Caffeine metabolism_Homo sapiens_hsa002320.64577881
70Thyroid hormone synthesis_Homo sapiens_hsa049180.62743026
71Fatty acid metabolism_Homo sapiens_hsa012120.60792625
72Fatty acid biosynthesis_Homo sapiens_hsa000610.59784032
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59627698
74Adherens junction_Homo sapiens_hsa045200.59313706
75Collecting duct acid secretion_Homo sapiens_hsa049660.55638694
76PPAR signaling pathway_Homo sapiens_hsa033200.55610971
77Salmonella infection_Homo sapiens_hsa051320.54565597
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53870644
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51050919
80Fatty acid elongation_Homo sapiens_hsa000620.50760006
81N-Glycan biosynthesis_Homo sapiens_hsa005100.49918335
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.48653734
83VEGF signaling pathway_Homo sapiens_hsa043700.48503718
84Phenylalanine metabolism_Homo sapiens_hsa003600.48314446
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48167876
86Long-term potentiation_Homo sapiens_hsa047200.47536783
87Insulin resistance_Homo sapiens_hsa049310.47288641
88Pyruvate metabolism_Homo sapiens_hsa006200.46571925
89Axon guidance_Homo sapiens_hsa043600.43886086
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43337872
91Fatty acid degradation_Homo sapiens_hsa000710.43203220
92Prion diseases_Homo sapiens_hsa050200.42652387
93Metabolic pathways_Homo sapiens_hsa011000.41975182
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39249455
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39030332
96Lysosome_Homo sapiens_hsa041420.38916344
97Long-term depression_Homo sapiens_hsa047300.38568501
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37554599
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.36509554
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.35280122
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34284201
102Pentose phosphate pathway_Homo sapiens_hsa000300.33463243
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.32742493
104AMPK signaling pathway_Homo sapiens_hsa041520.32108405
105Insulin signaling pathway_Homo sapiens_hsa049100.30753963
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29641554
107Arginine and proline metabolism_Homo sapiens_hsa003300.29285946
108Taste transduction_Homo sapiens_hsa047420.29087523
109Endocytosis_Homo sapiens_hsa041440.28888475
110Amoebiasis_Homo sapiens_hsa051460.28763983
111Peroxisome_Homo sapiens_hsa041460.27603180
112Melanogenesis_Homo sapiens_hsa049160.26793817
113Tryptophan metabolism_Homo sapiens_hsa003800.23996162
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.23615103
115Serotonergic synapse_Homo sapiens_hsa047260.23480241
116Gap junction_Homo sapiens_hsa045400.22651736
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21758643
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21643686
119Pertussis_Homo sapiens_hsa051330.21147947
120Hippo signaling pathway_Homo sapiens_hsa043900.20887044
121Amphetamine addiction_Homo sapiens_hsa050310.19625529
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.18739218
123Insulin secretion_Homo sapiens_hsa049110.18553228
124Notch signaling pathway_Homo sapiens_hsa043300.18518956
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17062718
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16331786
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16113300
128Carbon metabolism_Homo sapiens_hsa012000.15527084
129ABC transporters_Homo sapiens_hsa020100.15518474
130Glucagon signaling pathway_Homo sapiens_hsa049220.15236562
131Shigellosis_Homo sapiens_hsa051310.09740931
132TNF signaling pathway_Homo sapiens_hsa046680.08991108

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