TMEM56

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.25923304
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.25923304
3protoporphyrinogen IX metabolic process (GO:0046501)7.15709766
4L-phenylalanine metabolic process (GO:0006558)6.88318693
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.88318693
6aromatic amino acid family catabolic process (GO:0009074)6.49799488
7epoxygenase P450 pathway (GO:0019373)6.04730570
8protoporphyrinogen IX biosynthetic process (GO:0006782)5.99670315
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.91410402
10indole-containing compound catabolic process (GO:0042436)5.81505635
11indolalkylamine catabolic process (GO:0046218)5.81505635
12tryptophan catabolic process (GO:0006569)5.81505635
13bile acid biosynthetic process (GO:0006699)5.76458363
14kynurenine metabolic process (GO:0070189)5.75562772
15alpha-linolenic acid metabolic process (GO:0036109)5.61364078
16tryptophan metabolic process (GO:0006568)5.48780659
17porphyrin-containing compound biosynthetic process (GO:0006779)5.46741368
18urea metabolic process (GO:0019627)5.37843225
19urea cycle (GO:0000050)5.37843225
20omega-hydroxylase P450 pathway (GO:0097267)5.35733577
21glyoxylate metabolic process (GO:0046487)5.31360879
22cysteine metabolic process (GO:0006534)5.23153418
23high-density lipoprotein particle remodeling (GO:0034375)5.21421684
24negative regulation of fibrinolysis (GO:0051918)5.11759029
25porphyrin-containing compound metabolic process (GO:0006778)5.06936270
26complement activation, alternative pathway (GO:0006957)5.04436703
27regulation of protein activation cascade (GO:2000257)5.04380637
28regulation of fibrinolysis (GO:0051917)4.98852180
29sulfur amino acid catabolic process (GO:0000098)4.98718930
30protein carboxylation (GO:0018214)4.95675989
31peptidyl-glutamic acid carboxylation (GO:0017187)4.95675989
32nitrogen cycle metabolic process (GO:0071941)4.94761116
33bile acid metabolic process (GO:0008206)4.94257461
34tetrapyrrole biosynthetic process (GO:0033014)4.86618224
35hemoglobin metabolic process (GO:0020027)4.84521460
36serine family amino acid catabolic process (GO:0009071)4.81640719
37aromatic amino acid family metabolic process (GO:0009072)4.77192395
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.76874831
39tyrosine metabolic process (GO:0006570)4.70881388
40regulation of complement activation (GO:0030449)4.70490954
41reverse cholesterol transport (GO:0043691)4.59238945
42homocysteine metabolic process (GO:0050667)4.57887205
43lysine catabolic process (GO:0006554)4.56916398
44lysine metabolic process (GO:0006553)4.56916398
45regulation of triglyceride catabolic process (GO:0010896)4.55494205
46plasma lipoprotein particle remodeling (GO:0034369)4.49806974
47protein-lipid complex remodeling (GO:0034368)4.49806974
48macromolecular complex remodeling (GO:0034367)4.49806974
49regulation of cholesterol esterification (GO:0010872)4.49153567
50alpha-amino acid catabolic process (GO:1901606)4.47718247
51response to methylmercury (GO:0051597)4.46396212
52coenzyme catabolic process (GO:0009109)4.40980616
53acylglycerol homeostasis (GO:0055090)4.40516292
54triglyceride homeostasis (GO:0070328)4.40516292
55amino-acid betaine metabolic process (GO:0006577)4.40497679
56cellular ketone body metabolic process (GO:0046950)4.38379087
57drug metabolic process (GO:0017144)4.34573307
58iron ion import (GO:0097286)4.31935673
59glutamate metabolic process (GO:0006536)4.31250980
60phospholipid efflux (GO:0033700)4.29810900
61bile acid and bile salt transport (GO:0015721)4.26866664
62negative regulation of cholesterol transport (GO:0032375)4.18846212
63negative regulation of sterol transport (GO:0032372)4.18846212
64indolalkylamine metabolic process (GO:0006586)4.14737766
65cellular amino acid catabolic process (GO:0009063)4.13753371
66ethanol metabolic process (GO:0006067)4.10308746
67oxidative demethylation (GO:0070989)4.10251514
68cholesterol efflux (GO:0033344)4.09926564
69dicarboxylic acid biosynthetic process (GO:0043650)4.09233012
70gas transport (GO:0015669)4.06399534
71plasma lipoprotein particle clearance (GO:0034381)4.02032674
72glycine metabolic process (GO:0006544)3.98585669
73cellular biogenic amine catabolic process (GO:0042402)3.97720039
74amine catabolic process (GO:0009310)3.97720039
75oxygen transport (GO:0015671)3.97035798
76imidazole-containing compound metabolic process (GO:0052803)3.95018662
77cellular glucuronidation (GO:0052695)3.93879681
78cellular modified amino acid catabolic process (GO:0042219)3.92381529
79benzene-containing compound metabolic process (GO:0042537)3.90746097
80serine family amino acid metabolic process (GO:0009069)3.89670000
81ketone body metabolic process (GO:1902224)3.86249144
82drug catabolic process (GO:0042737)3.85823855
83heme metabolic process (GO:0042168)3.81869070
84low-density lipoprotein particle remodeling (GO:0034374)3.81779640
85heme biosynthetic process (GO:0006783)3.79149474
86plasma lipoprotein particle assembly (GO:0034377)3.77985056
87response to mercury ion (GO:0046689)3.77054928
88ethanol oxidation (GO:0006069)3.76172999
89cofactor catabolic process (GO:0051187)3.72949730
90arginine metabolic process (GO:0006525)3.67777130
91positive regulation of lipid catabolic process (GO:0050996)3.65954505
92very-low-density lipoprotein particle assembly (GO:0034379)3.65516778
93short-chain fatty acid metabolic process (GO:0046459)3.65508262
94regulation of cholesterol homeostasis (GO:2000188)3.64602682
95phospholipid homeostasis (GO:0055091)3.62361370
96carboxylic acid catabolic process (GO:0046395)3.61401384
97organic acid catabolic process (GO:0016054)3.61401384
98regulation of bile acid biosynthetic process (GO:0070857)3.60541707
99serine family amino acid biosynthetic process (GO:0009070)3.60092293
100fibrinolysis (GO:0042730)3.59957420
101acetyl-CoA metabolic process (GO:0006084)3.59702791
102S-adenosylmethionine metabolic process (GO:0046500)3.59039777
103aspartate family amino acid catabolic process (GO:0009068)3.55836221
104cytolysis (GO:0019835)3.54657861
105blood coagulation, intrinsic pathway (GO:0007597)3.53220587
106flavonoid metabolic process (GO:0009812)3.52057371
107positive regulation of triglyceride lipase activity (GO:0061365)3.51359050
108positive regulation of lipoprotein lipase activity (GO:0051006)3.51359050
109negative regulation of lipase activity (GO:0060192)3.51089279
110complement activation, classical pathway (GO:0006958)3.50960579
111phenylpropanoid metabolic process (GO:0009698)3.50085614
112cholesterol homeostasis (GO:0042632)3.49608523
113complement activation (GO:0006956)3.46895254
114uronic acid metabolic process (GO:0006063)3.45906433
115glucuronate metabolic process (GO:0019585)3.45906433
116sterol homeostasis (GO:0055092)3.44524875
117aldehyde catabolic process (GO:0046185)3.43596057
118protein activation cascade (GO:0072376)3.42983121
119plasma lipoprotein particle organization (GO:0071827)3.41509231
120exogenous drug catabolic process (GO:0042738)3.41431301
121negative regulation of protein activation cascade (GO:2000258)3.40548162
122tetrapyrrole metabolic process (GO:0033013)3.30223126
123heme transport (GO:0015886)3.27119489
124polyketide metabolic process (GO:0030638)3.21870503
125doxorubicin metabolic process (GO:0044598)3.21870503
126daunorubicin metabolic process (GO:0044597)3.21870503
127intestinal cholesterol absorption (GO:0030299)3.18587125
128protein-lipid complex assembly (GO:0065005)3.18287529
129positive regulation of hemostasis (GO:1900048)3.12354150
130positive regulation of blood coagulation (GO:0030194)3.12354150
131negative regulation of complement activation (GO:0045916)3.08466831
132response to lead ion (GO:0010288)3.02625911
133drug transmembrane transport (GO:0006855)3.00750077
134negative regulation of fatty acid biosynthetic process (GO:0045717)2.98917591
135fructose metabolic process (GO:0006000)2.95851843
136oxaloacetate metabolic process (GO:0006107)2.95558547
137negative regulation of blood coagulation (GO:0030195)2.92138643
138negative regulation of hemostasis (GO:1900047)2.92138643
139creatine metabolic process (GO:0006600)2.91629663
140erythrocyte maturation (GO:0043249)2.89912856
141protein-lipid complex subunit organization (GO:0071825)2.87092095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.53111028
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.34108467
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.05490666
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.95082457
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.95918449
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.26308098
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.91081238
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.90387598
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.31014541
10E2F7_22180533_ChIP-Seq_HELA_Human2.54105253
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14369388
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01780093
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6456688
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90039665
15IGF1R_20145208_ChIP-Seq_DFB_Human1.76617163
16KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.73650853
17HTT_18923047_ChIP-ChIP_STHdh_Human1.71186198
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.66823356
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65941759
20GATA1_22025678_ChIP-Seq_K562_Human1.61330045
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57564514
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43176263
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.39247124
24AR_21909140_ChIP-Seq_LNCAP_Human1.34234938
25TAF15_26573619_Chip-Seq_HEK293_Human1.33189776
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32773986
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32622882
28* EP300_21415370_ChIP-Seq_HL-1_Mouse1.32100124
29* GATA1_19941827_ChIP-Seq_MEL_Mouse1.27975869
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.22040319
31TP53_16413492_ChIP-PET_HCT116_Human1.20846626
32FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20696009
33TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19795738
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18327723
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17354242
36CLOCK_20551151_ChIP-Seq_293T_Human1.16187760
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15583797
38STAT3_23295773_ChIP-Seq_U87_Human1.15211984
39TCF4_23295773_ChIP-Seq_U87_Human1.14160290
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11636937
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11586212
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08969174
43TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08030122
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.08015861
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.06008760
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05515045
47* PHF8_20622853_ChIP-Seq_HELA_Human1.05190847
48* HNFA_21074721_ChIP-Seq_CACO-2_Human1.04389511
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02223584
50* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01709109
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.01430066
52RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00149304
53ER_23166858_ChIP-Seq_MCF-7_Human0.99616860
54VDR_22108803_ChIP-Seq_LS180_Human0.98338810
55* NFYB_21822215_ChIP-Seq_K562_Human0.98140577
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97946927
57NFYA_21822215_ChIP-Seq_K562_Human0.97285919
58* TBL1_22424771_ChIP-Seq_293T_Human0.96898084
59* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96051045
60* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92533220
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92389094
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92285307
63* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91965251
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91380786
65FOXM1_23109430_ChIP-Seq_U2OS_Human0.90375195
66ZNF263_19887448_ChIP-Seq_K562_Human0.90261750
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89994166
68E2F1_18555785_Chip-Seq_ESCs_Mouse0.88293806
69SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87841181
70OCT4_18555785_Chip-Seq_ESCs_Mouse0.87518547
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86937822
72NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86937822
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86568978
74SOX2_18555785_Chip-Seq_ESCs_Mouse0.85873317
75* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85670679
76GATA6_25053715_ChIP-Seq_YYC3_Human0.85507963
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85441911
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85343882
79CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85118253
80* ETV1_20927104_ChIP-Seq_GIST48_Human0.84762580
81* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84473400
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83959828
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83444071
84* STAT3_18555785_Chip-Seq_ESCs_Mouse0.83411023
85NANOG_18555785_Chip-Seq_ESCs_Mouse0.83230130
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82946792
87* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82801913
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.81985957
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81866730
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81121231
91PIAS1_25552417_ChIP-Seq_VCAP_Human0.80907682
92ERG_21242973_ChIP-ChIP_JURKAT_Human0.78372074
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78091336
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77824993
95ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77610539
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.76916169
97GBX2_23144817_ChIP-Seq_PC3_Human0.76900308
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76753750
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73972826
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.73770820
101BCAT_22108803_ChIP-Seq_LS180_Human0.72633728
102GATA4_25053715_ChIP-Seq_YYC3_Human0.67232276
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.66675329
104* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65694705
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.64806470
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.62654125
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62624594
108CBP_21632823_ChIP-Seq_H3396_Human0.62405252
109REST_21632747_ChIP-Seq_MESCs_Mouse0.61545282
110FOXA1_25552417_ChIP-Seq_VCAP_Human0.61452615
111REST_18959480_ChIP-ChIP_MESCs_Mouse0.60673342
112* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.60018905
113GATA1_19941826_ChIP-Seq_K562_Human0.59584041
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.58921969
115RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58702726
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58518378
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.58515944
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.57392448
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.57183800
120* MYC_19915707_ChIP-ChIP_AK7_Human0.56367023
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.56156290
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.55509442
123SMAD4_21741376_ChIP-Seq_EPCs_Human0.55250326
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.55195452
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.54548536
126STAT1_17558387_ChIP-Seq_HELA_Human0.54433837
127CTBP1_25329375_ChIP-Seq_LNCAP_Human0.52455035
128EGR1_19032775_ChIP-ChIP_M12_Human0.52226033
129P53_21459846_ChIP-Seq_SAOS-2_Human0.51914052
130CDX2_22108803_ChIP-Seq_LS180_Human0.51057264
131SMAD4_21799915_ChIP-Seq_A2780_Human0.50905101
132NR3C1_23031785_ChIP-Seq_PC12_Mouse0.50900848
133* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.50608427
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.50265310
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.50074701
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49616638
137NCOR_22424771_ChIP-Seq_293T_Human0.49351874
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.48775087
139ESET_19884257_ChIP-Seq_ESCs_Mouse0.48709197
140* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.48446679
141CBP_20019798_ChIP-Seq_JUKART_Human0.47881352
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.47881352
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.47878706
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.47572922
145AR_20517297_ChIP-Seq_VCAP_Human0.47348593
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.47280377
147* GATA2_19941826_ChIP-Seq_K562_Human0.47267906
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.46906496
149TAF2_19829295_ChIP-Seq_ESCs_Human0.46877493
150LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.46003398
151* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.45988502
152CEBPB_22108803_ChIP-Seq_LS180_Human0.45955141
153DNAJC2_21179169_ChIP-ChIP_NT2_Human0.45503503
154P300_19829295_ChIP-Seq_ESCs_Human0.45502377
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.45437125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.25417656
2MP0005360_urolithiasis7.02302815
3MP0005085_abnormal_gallbladder_physiolo6.39199415
4MP0005365_abnormal_bile_salt6.14063819
5MP0008875_abnormal_xenobiotic_pharmacok4.97166998
6MP0003252_abnormal_bile_duct3.90943950
7MP0003806_abnormal_nucleotide_metabolis3.88571052
8MP0010329_abnormal_lipoprotein_level3.52860921
9MP0005083_abnormal_biliary_tract3.23069805
10MP0009840_abnormal_foam_cell2.93185813
11MP0003195_calcinosis2.87436820
12MP0005332_abnormal_amino_acid2.66655504
13MP0001666_abnormal_nutrient_absorption2.59324631
14MP0002118_abnormal_lipid_homeostasis2.15320895
15MP0004019_abnormal_vitamin_homeostasis2.07424321
16MP0003191_abnormal_cellular_cholesterol2.05552788
17MP0002138_abnormal_hepatobiliary_system2.04841014
18MP0003868_abnormal_feces_composition2.03869096
19MP0000609_abnormal_liver_physiology2.03726393
20MP0004145_abnormal_muscle_electrophysio1.84727499
21MP0004215_abnormal_myocardial_fiber1.71576047
22MP0005319_abnormal_enzyme/_coenzyme1.70433810
23MP0003656_abnormal_erythrocyte_physiolo1.69213170
24MP0004084_abnormal_cardiac_muscle1.68138636
25MP0000749_muscle_degeneration1.60912370
26MP0008775_abnormal_heart_ventricle1.59244422
27MP0001764_abnormal_homeostasis1.59081038
28MP0005584_abnormal_enzyme/coenzyme_acti1.53466632
29MP0003011_delayed_dark_adaptation1.48148563
30MP0004036_abnormal_muscle_relaxation1.45405819
31MP0009697_abnormal_copulation1.40219874
32MP0002877_abnormal_melanocyte_morpholog1.38624973
33MP0005451_abnormal_body_composition1.26710479
34MP0000604_amyloidosis1.25418096
35MP0003329_amyloid_beta_deposits1.15019638
36MP0009643_abnormal_urine_homeostasis1.11442331
37MP0005647_abnormal_sex_gland1.09281172
38MP0008995_early_reproductive_senescence1.08521903
39MP0008057_abnormal_DNA_replication1.06202404
40MP0005636_abnormal_mineral_homeostasis1.05915133
41MP0003646_muscle_fatigue1.05417751
42MP0004484_altered_response_of1.05095520
43MP0002972_abnormal_cardiac_muscle1.02436197
44MP0005330_cardiomyopathy1.01694371
45MP0000598_abnormal_liver_morphology1.00042830
46MP0002876_abnormal_thyroid_physiology0.98258489
47MP0002078_abnormal_glucose_homeostasis0.96231325
48MP0002254_reproductive_system_inflammat0.95918757
49MP0003186_abnormal_redox_activity0.95683739
50MP0005535_abnormal_body_temperature0.95648129
51MP0006036_abnormal_mitochondrial_physio0.93053195
52MP0005620_abnormal_muscle_contractility0.88979529
53MP0006138_congestive_heart_failure0.87503268
54MP0000747_muscle_weakness0.86743711
55MP0002822_catalepsy0.86250149
56MP0004130_abnormal_muscle_cell0.86203497
57MP0009764_decreased_sensitivity_to0.85652064
58MP0000462_abnormal_digestive_system0.84064048
59MP0009642_abnormal_blood_homeostasis0.81893963
60MP0002837_dystrophic_cardiac_calcinosis0.81485988
61MP0002332_abnormal_exercise_endurance0.81096947
62MP0003690_abnormal_glial_cell0.80798921
63MP0004087_abnormal_muscle_fiber0.79995744
64MP0005084_abnormal_gallbladder_morpholo0.79971542
65MP0003950_abnormal_plasma_membrane0.79565900
66MP0005408_hypopigmentation0.79394463
67MP0000751_myopathy0.78990483
68MP0009763_increased_sensitivity_to0.77179211
69MP0004147_increased_porphyrin_level0.76758007
70MP0005385_cardiovascular_system_phenoty0.74907682
71MP0001544_abnormal_cardiovascular_syste0.74907682
72MP0005376_homeostasis/metabolism_phenot0.73740489
73MP0002971_abnormal_brown_adipose0.72196478
74MP0006035_abnormal_mitochondrial_morpho0.72068813
75MP0004085_abnormal_heartbeat0.71498487
76MP0003705_abnormal_hypodermis_morpholog0.71217659
77MP0005220_abnormal_exocrine_pancreas0.70930466
78MP0005334_abnormal_fat_pad0.70842779
79MP0000639_abnormal_adrenal_gland0.70386394
80MP0002009_preneoplasia0.69586079
81MP0004043_abnormal_pH_regulation0.68713168
82MP0001661_extended_life_span0.67529821
83MP0009765_abnormal_xenobiotic_induced0.67497067
84MP0005448_abnormal_energy_balance0.65197001
85MP0008469_abnormal_protein_level0.64791139
86MP0008260_abnormal_autophagy0.63531673
87MP0010630_abnormal_cardiac_muscle0.62528408
88MP0005670_abnormal_white_adipose0.62225560
89MP0004924_abnormal_behavior0.61997755
90MP0005386_behavior/neurological_phenoty0.61997755
91MP0008874_decreased_physiological_sensi0.60405141
92MP0008872_abnormal_physiological_respon0.60217462
93MP0010368_abnormal_lymphatic_system0.59261552
94MP0005266_abnormal_metabolism0.58954837
95MP0001756_abnormal_urination0.58859518
96MP0001529_abnormal_vocalization0.57644211
97MP0002106_abnormal_muscle_physiology0.57614230
98MP0009780_abnormal_chondrocyte_physiolo0.55835028
99MP0003953_abnormal_hormone_level0.54892934
100MP0003632_abnormal_nervous_system0.51149569
101MP0001664_abnormal_digestion0.50659853
102MP0003137_abnormal_impulse_conducting0.49936707
103MP0002928_abnormal_bile_duct0.48024815
104MP0002909_abnormal_adrenal_gland0.47947335
105MP0000579_abnormal_nail_morphology0.46975728
106MP0004270_analgesia0.45285531
107MP0003633_abnormal_nervous_system0.45272829
108MP0003638_abnormal_response/metabolism_0.43837837
109MP0003075_altered_response_to0.43790437
110MP0000230_abnormal_systemic_arterial0.43124317
111MP0001765_abnormal_ion_homeostasis0.39776661
112MP0002090_abnormal_vision0.39492853
113MP0010234_abnormal_vibrissa_follicle0.38757764
114MP0005395_other_phenotype0.37726989
115MP0001944_abnormal_pancreas_morphology0.36910833
116MP0005646_abnormal_pituitary_gland0.36896246
117MP0005248_abnormal_Harderian_gland0.36383589
118MP0005166_decreased_susceptibility_to0.35168694
119MP0003631_nervous_system_phenotype0.34938836
120MP0002796_impaired_skin_barrier0.34438675
121MP0000427_abnormal_hair_cycle0.33635464
122MP0002069_abnormal_eating/drinking_beha0.33620722
123MP0003879_abnormal_hair_cell0.33438958
124MP0003718_maternal_effect0.33117632
125MP0009745_abnormal_behavioral_response0.32314768
126MP0004381_abnormal_hair_follicle0.32097140
127MP0008873_increased_physiological_sensi0.31325535
128MP0004142_abnormal_muscle_tone0.30875818
129MP0002269_muscular_atrophy0.30728496
130MP0005187_abnormal_penis_morphology0.29967935
131MP0009672_abnormal_birth_weight0.29954419
132MP0004782_abnormal_surfactant_physiolog0.29555200
133MP0005666_abnormal_adipose_tissue0.29151842
134MP0002064_seizures0.29127817

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.11725926
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.02345029
3Deep venous thrombosis (HP:0002625)6.90737625
4Abnormality of the heme biosynthetic pathway (HP:0010472)6.31310165
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.21271075
6Prolonged partial thromboplastin time (HP:0003645)6.19528175
7Hypobetalipoproteinemia (HP:0003563)6.19095881
8Xanthomatosis (HP:0000991)6.07362501
9Hyperlipoproteinemia (HP:0010980)5.31244392
10Complement deficiency (HP:0004431)5.08076844
11Hypolipoproteinemia (HP:0010981)4.61186609
12Epidermoid cyst (HP:0200040)4.52200713
13Hyperglycinemia (HP:0002154)4.43404074
14Hyperammonemia (HP:0001987)4.33704650
15Ketosis (HP:0001946)4.28660634
16Abnormality of the common coagulation pathway (HP:0010990)4.26644185
17Joint hemorrhage (HP:0005261)4.23593492
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.19834146
19Osteomalacia (HP:0002749)4.13545290
20Fat malabsorption (HP:0002630)4.06912105
21Hypoalphalipoproteinemia (HP:0003233)3.99851609
22Abnormality of methionine metabolism (HP:0010901)3.95182679
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.91400839
24Conjugated hyperbilirubinemia (HP:0002908)3.86604351
25Hypoglycemic coma (HP:0001325)3.84008206
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.83519290
27Abnormality of serine family amino acid metabolism (HP:0010894)3.77731791
28Abnormality of glycine metabolism (HP:0010895)3.77731791
29Hyperglycinuria (HP:0003108)3.73690772
30Abnormality of the intrinsic pathway (HP:0010989)3.71355491
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.70066896
32Abnormality of complement system (HP:0005339)3.56229361
33Hyperbilirubinemia (HP:0002904)3.45358361
34Hypercholesterolemia (HP:0003124)3.40989751
35Polycythemia (HP:0001901)3.39759792
36Ketoacidosis (HP:0001993)3.25368788
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17157477
38Acanthocytosis (HP:0001927)3.15947258
39Abnormality of pyrimidine metabolism (HP:0004353)3.14417501
40Paralysis (HP:0003470)3.07237477
41Abnormality of reticulocytes (HP:0004312)3.06270890
42Hypochromic microcytic anemia (HP:0004840)3.01676373
43Abnormality of fatty-acid metabolism (HP:0004359)3.01646008
44Steatorrhea (HP:0002570)2.94969001
45Abnormality of serum amino acid levels (HP:0003112)2.94651147
46Spontaneous abortion (HP:0005268)2.93250312
47Abnormal hemoglobin (HP:0011902)2.91633308
48Delayed CNS myelination (HP:0002188)2.91573668
49Diaphragmatic weakness (HP:0009113)2.90894080
50Gout (HP:0001997)2.88600926
51Skin nodule (HP:0200036)2.87913861
52Abnormal gallbladder morphology (HP:0012437)2.83240594
53Abnormality of nucleobase metabolism (HP:0010932)2.83008124
54Hepatocellular carcinoma (HP:0001402)2.82776185
55Abnormal gallbladder physiology (HP:0012438)2.76949409
56Cholecystitis (HP:0001082)2.76949409
57Cholelithiasis (HP:0001081)2.74363841
58Hypoglycemic seizures (HP:0002173)2.73971239
59Bundle branch block (HP:0011710)2.73487012
60Metabolic acidosis (HP:0001942)2.70421686
61Abnormality of purine metabolism (HP:0004352)2.67303435
62Microcytic anemia (HP:0001935)2.64866834
63Ileus (HP:0002595)2.55970561
64Toxemia of pregnancy (HP:0100603)2.53744410
65Lethargy (HP:0001254)2.52203228
66Poikilocytosis (HP:0004447)2.48985547
67Sudden death (HP:0001699)2.45224771
68Myocardial infarction (HP:0001658)2.45156379
69Hyperinsulinemic hypoglycemia (HP:0000825)2.42930366
70Irritability (HP:0000737)2.40285941
71Neonatal onset (HP:0003623)2.36001022
72Cerebral edema (HP:0002181)2.34994341
73Dicarboxylic aciduria (HP:0003215)2.33796157
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33796157
75Sensorimotor neuropathy (HP:0007141)2.31920537
76Vascular calcification (HP:0004934)2.26450755
77Brushfield spots (HP:0001088)2.25287321
78Ventricular fibrillation (HP:0001663)2.24698089
79Systemic lupus erythematosus (HP:0002725)2.24600580
80Spastic diplegia (HP:0001264)2.24145328
81Abnormality of the gallbladder (HP:0005264)2.23381919
82Status epilepticus (HP:0002133)2.21314554
83Generalized hypopigmentation of hair (HP:0011358)2.17490863
84Late onset (HP:0003584)2.16794341
85Malnutrition (HP:0004395)2.15277991
86Mitral stenosis (HP:0001718)2.14601914
87Amyloidosis (HP:0011034)2.10830804
88Heart block (HP:0012722)2.10718960
89Abnormality of iron homeostasis (HP:0011031)2.10646222
90Fair hair (HP:0002286)2.07707412
91Cerebral palsy (HP:0100021)2.06793109
92Glomerulonephritis (HP:0000099)2.05765032
93Syncope (HP:0001279)2.05001936
94Exercise-induced myalgia (HP:0003738)2.04575324
95Atrioventricular block (HP:0001678)2.04566242
96Hyporeflexia of lower limbs (HP:0002600)2.02983087
97Enlarged kidneys (HP:0000105)2.01159544
98Hyperglycemia (HP:0003074)2.00815387
99Hyperventilation (HP:0002883)1.99166738
100Vomiting (HP:0002013)1.99054918
101Hypochromic anemia (HP:0001931)1.97876974
102Muscle fiber inclusion bodies (HP:0100299)1.97846750
103Cardiovascular calcification (HP:0011915)1.96000041
104Glycosuria (HP:0003076)1.95844791
105Abnormality of urine glucose concentration (HP:0011016)1.95844791
106Reticulocytosis (HP:0001923)1.95134247
107Pancreatitis (HP:0001733)1.94873397
108Abnormal atrioventricular conduction (HP:0005150)1.92827137
109Abnormality of the left ventricular outflow tract (HP:0011103)1.91442935
110Subaortic stenosis (HP:0001682)1.91442935
111Right ventricular cardiomyopathy (HP:0011663)1.89849388
112Increased mean platelet volume (HP:0011877)1.88187703
113Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.87609622
114Rickets (HP:0002748)1.87508553
115Ventricular arrhythmia (HP:0004308)1.87238423
116Nemaline bodies (HP:0003798)1.87162696
117Symptomatic seizures (HP:0011145)1.85856554
118Menorrhagia (HP:0000132)1.85444963
119Confusion (HP:0001289)1.85233726
120Nausea (HP:0002018)1.84579252
121Increased purine levels (HP:0004368)1.82800308
122Hyperuricemia (HP:0002149)1.82800308
123EMG: myopathic abnormalities (HP:0003458)1.82164709
124Alkalosis (HP:0001948)1.79683930
125Postural instability (HP:0002172)1.79608863
126Esophageal varix (HP:0002040)1.78890032
127Calf muscle hypertrophy (HP:0008981)1.78288401
128Generalized aminoaciduria (HP:0002909)1.77882430
129Opisthotonus (HP:0002179)1.77252851
130Tetraplegia (HP:0002445)1.76924033
131Muscle hypertrophy of the lower extremities (HP:0008968)1.76304015
132Gingival bleeding (HP:0000225)1.75887145
133Recurrent gram-negative bacterial infections (HP:0005420)1.75733889
134Hemorrhage of the eye (HP:0011885)1.75370784
135Acute hepatic failure (HP:0006554)1.74911557
136Nephritis (HP:0000123)1.74900136
137Palpitations (HP:0001962)1.74007040
138Abnormality of transition element cation homeostasis (HP:0011030)1.73472108
139Arthropathy (HP:0003040)1.73048872
140Abnormality of vitamin metabolism (HP:0100508)1.71813128
141Thrombophlebitis (HP:0004418)1.71272243
142Death in childhood (HP:0003819)1.70907448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.72222093
2EIF2AK14.68097611
3OBSCN4.08485929
4SIK13.60019276
5INSRR3.44778361
6MAP2K43.34297340
7FGFR43.12712422
8DAPK22.82359114
9TAOK32.81854626
10ERN12.75858935
11ERBB42.60202103
12SCYL22.38586054
13PRPF4B2.33667747
14EPHA42.18002204
15TAF12.16223332
16FRK2.01769354
17STK241.93127219
18STK41.93021873
19MST1R1.92864603
20PINK11.80449651
21MAP3K41.79431552
22PIK3CG1.78848391
23PIK3CA1.75586800
24TRPM71.64794849
25FGFR21.58590111
26WNK11.57753369
27MAPK111.54053755
28BRSK21.49573342
29STK31.42549641
30LATS11.40726843
31NTRK31.37826985
32TTN1.29070739
33AKT31.24208687
34PDK41.24066058
35PDK31.24066058
36SGK21.22962072
37MAP2K71.19797324
38KSR11.18221505
39SGK31.17944417
40NTRK11.17898261
41MAP3K71.15707573
42SGK2231.15366231
43SGK4941.15366231
44JAK21.14169264
45MAP3K21.13689023
46ABL21.10008426
47SGK11.08768118
48PRKCG1.07974906
49PKN21.06622620
50TRIB31.04721928
51CAMKK11.04548029
52CASK1.03417155
53PRKAA21.02327107
54KSR21.02038821
55ACVR1B1.00386582
56MAP3K120.99080098
57CAMK2G0.99037569
58EEF2K0.98914019
59FLT30.98091831
60PLK20.97454875
61PRKCZ0.96448918
62PDPK10.95650258
63MAP3K90.95280065
64NEK90.94984361
65RET0.90145971
66ICK0.88578978
67ERBB20.88400808
68MYLK0.88320419
69PRKAA10.88243744
70PTK60.87072152
71MAPK120.85695845
72BMX0.84917951
73MAP3K10.84701660
74MET0.83673204
75PIM10.83540276
76PRKACG0.83401367
77MINK10.83382876
78DMPK0.83320791
79BRSK10.81564463
80PRKCI0.80683466
81PBK0.79754494
82STK110.79248301
83PDK10.76335700
84MAP2K30.75851024
85RAF10.75291788
86RPS6KA50.74011687
87MAPK40.73624496
88CLK10.73261753
89PLK30.72704696
90TAOK20.70965431
91MST40.70671090
92JAK10.69598366
93AKT20.69435957
94STK380.68592083
95CAMKK20.67805919
96MAPK150.67761111
97MAP2K10.66185259
98RIPK10.63770320
99TYK20.63483800
100PAK60.63171465
101CSNK1G20.62346043
102NEK10.61670626
103BRAF0.61643264
104STK390.61087572
105GRK50.60833617
106ZAK0.60670706
107DAPK10.59930989
108BMPR20.59570395
109CAMK2D0.57953883
110PTK2B0.54206205
111PAK30.53790489
112LATS20.53007065
113MAP2K60.52865979
114OXSR10.52834717
115CAMK1G0.52723010
116CAMK10.52511633
117MAPKAPK30.52106078
118PDK20.51984094
119GSK3A0.51483929
120STK38L0.51481377
121GRK60.50587164
122CAMK1D0.50402254
123CAMK2B0.50273313
124TTK0.47566694
125CAMK2A0.47060266
126PTK20.46998500
127MAPK70.46661320
128PRKCH0.44843662
129LMTK20.44730177
130MAP3K60.44655840
131MAP3K130.43437630
132PHKG20.41745943
133PHKG10.41745943
134RPS6KA30.41591818
135CSNK1G10.41293899
136MAP3K110.41229413
137DYRK1A0.40987049
138MAP3K50.40818170
139PRKCQ0.40491010
140PRKCA0.38966027
141FER0.38913036
142CAMK40.36942073
143PRKACA0.36026928
144DYRK1B0.35432106
145EPHA30.35222203
146PKN10.35057830
147CDK50.34813485
148EPHB10.34697334
149FGFR30.33533330

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.41585278
2Nitrogen metabolism_Homo sapiens_hsa009103.98984575
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38182426
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.12701091
5Arginine biosynthesis_Homo sapiens_hsa002203.04049571
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75004405
7Tryptophan metabolism_Homo sapiens_hsa003802.59492837
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58293107
9Complement and coagulation cascades_Homo sapiens_hsa046102.53470622
10Fatty acid degradation_Homo sapiens_hsa000712.46229227
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40822091
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31620914
13Butanoate metabolism_Homo sapiens_hsa006502.24094677
14Peroxisome_Homo sapiens_hsa041462.01878126
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01712127
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97213808
17Propanoate metabolism_Homo sapiens_hsa006401.95707212
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.87786560
19Fatty acid metabolism_Homo sapiens_hsa012121.85728372
20PPAR signaling pathway_Homo sapiens_hsa033201.84218864
21Histidine metabolism_Homo sapiens_hsa003401.81174137
22Chemical carcinogenesis_Homo sapiens_hsa052041.76748150
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.75244764
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73454073
25beta-Alanine metabolism_Homo sapiens_hsa004101.68663114
26Bile secretion_Homo sapiens_hsa049761.63339502
27Retinol metabolism_Homo sapiens_hsa008301.59363085
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56732699
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.55979412
30Caffeine metabolism_Homo sapiens_hsa002321.54863384
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53623666
32Phenylalanine metabolism_Homo sapiens_hsa003601.49625774
33Pyruvate metabolism_Homo sapiens_hsa006201.46140688
34Selenocompound metabolism_Homo sapiens_hsa004501.43912804
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43457035
36Staphylococcus aureus infection_Homo sapiens_hsa051501.41868209
37Fatty acid elongation_Homo sapiens_hsa000621.40727632
38Tyrosine metabolism_Homo sapiens_hsa003501.40123602
39Sulfur metabolism_Homo sapiens_hsa009201.38691606
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37007887
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.28520731
42ABC transporters_Homo sapiens_hsa020101.27873163
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.26229550
44Starch and sucrose metabolism_Homo sapiens_hsa005001.24932300
45Vitamin B6 metabolism_Homo sapiens_hsa007501.21973616
46Fat digestion and absorption_Homo sapiens_hsa049751.19446566
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16831069
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16560491
49Biosynthesis of amino acids_Homo sapiens_hsa012301.13146173
50Carbon metabolism_Homo sapiens_hsa012001.09660094
51Steroid biosynthesis_Homo sapiens_hsa001001.08566606
52Folate biosynthesis_Homo sapiens_hsa007901.03985496
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93362637
54Arginine and proline metabolism_Homo sapiens_hsa003300.87466201
55Vitamin digestion and absorption_Homo sapiens_hsa049770.85463851
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.84396559
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75455765
58Glycerolipid metabolism_Homo sapiens_hsa005610.75169365
59Fatty acid biosynthesis_Homo sapiens_hsa000610.74756385
60Sulfur relay system_Homo sapiens_hsa041220.70178992
61Arachidonic acid metabolism_Homo sapiens_hsa005900.70043951
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69740661
63Lysine degradation_Homo sapiens_hsa003100.67119676
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63810319
65Mineral absorption_Homo sapiens_hsa049780.61439416
66Systemic lupus erythematosus_Homo sapiens_hsa053220.50041922
67Glutathione metabolism_Homo sapiens_hsa004800.49754821
68Pentose phosphate pathway_Homo sapiens_hsa000300.49639667
69Metabolic pathways_Homo sapiens_hsa011000.44134530
70Prion diseases_Homo sapiens_hsa050200.39647826
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37070547
72One carbon pool by folate_Homo sapiens_hsa006700.36074653
73Glucagon signaling pathway_Homo sapiens_hsa049220.31797600
74Long-term potentiation_Homo sapiens_hsa047200.31351818
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.30675688
76Insulin resistance_Homo sapiens_hsa049310.29361176
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28909093
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.28562034
79Renin-angiotensin system_Homo sapiens_hsa046140.26661547
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25534488
81Fructose and mannose metabolism_Homo sapiens_hsa000510.24723066
82Linoleic acid metabolism_Homo sapiens_hsa005910.22202575
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21841991
84Galactose metabolism_Homo sapiens_hsa000520.20489000
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20444469
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19109889
87Pancreatic secretion_Homo sapiens_hsa049720.18458759
88Alcoholism_Homo sapiens_hsa050340.17368613
89Serotonergic synapse_Homo sapiens_hsa047260.14754754
90Dilated cardiomyopathy_Homo sapiens_hsa054140.13901962
91Renin secretion_Homo sapiens_hsa049240.12477929
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.11022140
93AMPK signaling pathway_Homo sapiens_hsa041520.09339352
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07456518
95Inositol phosphate metabolism_Homo sapiens_hsa005620.07175352
96GABAergic synapse_Homo sapiens_hsa047270.04542537
97Insulin signaling pathway_Homo sapiens_hsa049100.02847110
98Regulation of autophagy_Homo sapiens_hsa041400.01898322
99Amphetamine addiction_Homo sapiens_hsa05031-0.1376772
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1326225
101Synaptic vesicle cycle_Homo sapiens_hsa04721-0.1278029
102Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1254287
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.1081778
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1076399
105Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1034017
106Nicotine addiction_Homo sapiens_hsa05033-0.0853807
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0810177
108Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0807421
109Circadian rhythm_Homo sapiens_hsa04710-0.0682746
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0482517
111Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0280025
112Insulin secretion_Homo sapiens_hsa04911-0.0125793
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0070329
114Type II diabetes mellitus_Homo sapiens_hsa04930-0.0060938
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0036052

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