TMEM57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)4.19075323
2gas transport (GO:0015669)3.86618647
3protoporphyrinogen IX metabolic process (GO:0046501)3.85207273
4pre-miRNA processing (GO:0031054)3.78871130
5mitotic sister chromatid cohesion (GO:0007064)3.67286042
6erythrocyte development (GO:0048821)3.54459376
7cellular response to nerve growth factor stimulus (GO:1990090)3.50845867
8response to nerve growth factor (GO:1990089)3.50845867
9regulation of hippo signaling (GO:0035330)3.40548633
10cytoplasmic mRNA processing body assembly (GO:0033962)3.37592507
11cell migration in hindbrain (GO:0021535)3.32107143
12macroautophagy (GO:0016236)3.18851148
13protoporphyrinogen IX biosynthetic process (GO:0006782)3.14476791
14pyrimidine nucleobase catabolic process (GO:0006208)3.10082196
15hemoglobin metabolic process (GO:0020027)3.09943297
16stress granule assembly (GO:0034063)3.07645871
17regulation of NFAT protein import into nucleus (GO:0051532)3.06898741
18negative regulation of potassium ion transmembrane transport (GO:1901380)3.05828280
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.03390471
20insulin-like growth factor receptor signaling pathway (GO:0048009)3.02706825
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02161936
22layer formation in cerebral cortex (GO:0021819)2.94556722
23glial cell proliferation (GO:0014009)2.87631942
24negative regulation of erythrocyte differentiation (GO:0045647)2.83408270
25dendrite morphogenesis (GO:0048813)2.81695938
26definitive hemopoiesis (GO:0060216)2.80878695
27positive regulation of glycogen biosynthetic process (GO:0045725)2.80194251
28regulation of ARF protein signal transduction (GO:0032012)2.73597788
29phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.72201411
30sarcoplasmic reticulum calcium ion transport (GO:0070296)2.71455819
31negative regulation of neurotransmitter secretion (GO:0046929)2.71210854
32peptidyl-lysine dimethylation (GO:0018027)2.68867450
33regulation of RNA export from nucleus (GO:0046831)2.66452407
34cerebellar granule cell differentiation (GO:0021707)2.66266202
35regulation of fatty acid beta-oxidation (GO:0031998)2.66223895
36regulation of clathrin-mediated endocytosis (GO:2000369)2.65950206
37locomotory exploration behavior (GO:0035641)2.65087680
38protein demethylation (GO:0006482)2.64814448
39protein dealkylation (GO:0008214)2.64814448
40nuclear pore complex assembly (GO:0051292)2.63097177
41negative regulation of fatty acid biosynthetic process (GO:0045717)2.62708521
42histone H3-K36 demethylation (GO:0070544)2.61154591
43positive regulation of fatty acid beta-oxidation (GO:0032000)2.59468162
44protein targeting to Golgi (GO:0000042)2.58659618
45exocrine pancreas development (GO:0031017)2.58333331
46gene silencing by RNA (GO:0031047)2.57195679
47ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.53767507
48nucleobase catabolic process (GO:0046113)2.53437963
49hippo signaling (GO:0035329)2.50519211
50rRNA catabolic process (GO:0016075)2.49451038
51regulation of response to osmotic stress (GO:0047484)2.48714197
52erythrocyte maturation (GO:0043249)2.48069537
53COPI coating of Golgi vesicle (GO:0048205)2.47748691
54Golgi transport vesicle coating (GO:0048200)2.47748691
55negative regulation of fibrinolysis (GO:0051918)2.47324597
56cerebellar Purkinje cell differentiation (GO:0021702)2.47300565
57regulation of fibrinolysis (GO:0051917)2.46045332
58organelle transport along microtubule (GO:0072384)2.45897086
59axon extension (GO:0048675)2.44644314
60establishment of protein localization to Golgi (GO:0072600)2.43362855
61cell differentiation in hindbrain (GO:0021533)2.42661047
62positive regulation of glycogen metabolic process (GO:0070875)2.42628287
63activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42371609
64positive regulation of histone deacetylation (GO:0031065)2.41244885
65dorsal/ventral axis specification (GO:0009950)2.41088245
66regulation of triglyceride catabolic process (GO:0010896)2.40567714
67retrograde transport, vesicle recycling within Golgi (GO:0000301)2.39975441
68histone H3-K4 trimethylation (GO:0080182)2.39951195
69nuclear pore organization (GO:0006999)2.39946911
70glucocorticoid receptor signaling pathway (GO:0042921)2.39780014
71gastrulation with mouth forming second (GO:0001702)2.39118792
72negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.37938309
73interkinetic nuclear migration (GO:0022027)2.36636818
74positive regulation of hormone biosynthetic process (GO:0046886)2.34132204
75central nervous system projection neuron axonogenesis (GO:0021952)2.34128619
76establishment of nucleus localization (GO:0040023)2.33936121
77histone lysine demethylation (GO:0070076)2.33192000
78dendritic spine morphogenesis (GO:0060997)2.32998927
79protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.32918649
80endoplasmic reticulum organization (GO:0007029)2.32902333
81synaptic vesicle docking involved in exocytosis (GO:0016081)2.32503030
82fructose metabolic process (GO:0006000)2.31399395
83embryonic retina morphogenesis in camera-type eye (GO:0060059)2.31136414
84positive regulation of synapse maturation (GO:0090129)2.30835271
85negative regulation of organelle assembly (GO:1902116)2.29976809
86central nervous system neuron axonogenesis (GO:0021955)2.29296640
87positive regulation of macroautophagy (GO:0016239)2.28609198
88regulation of cholesterol homeostasis (GO:2000188)2.28578176
89cytoskeletal anchoring at plasma membrane (GO:0007016)2.28199373
90regulation of nucleobase-containing compound transport (GO:0032239)2.27650496
91suckling behavior (GO:0001967)2.26345170
92L-alpha-amino acid transmembrane transport (GO:1902475)2.26174375
93monoubiquitinated protein deubiquitination (GO:0035520)2.26169291
94cerebellum development (GO:0021549)2.25743667
95gene silencing (GO:0016458)2.25494810
96neuron cell-cell adhesion (GO:0007158)2.24626955
97positive regulation of nuclease activity (GO:0032075)2.24049673
98vesicle transport along microtubule (GO:0047496)2.23986957
99axonal fasciculation (GO:0007413)2.23925099
100negative regulation of inclusion body assembly (GO:0090084)2.23107830
101histone H2A monoubiquitination (GO:0035518)2.22123175
102negative regulation of cell size (GO:0045792)2.21451159
103peptidyl-glutamic acid carboxylation (GO:0017187)2.21290701
104protein carboxylation (GO:0018214)2.21290701
105negative regulation of histone methylation (GO:0031061)2.21132776
106regulation of erythrocyte differentiation (GO:0045646)2.20873136
107ionotropic glutamate receptor signaling pathway (GO:0035235)2.20350138
108peptidyl-threonine phosphorylation (GO:0018107)2.19785954
109coronary vasculature morphogenesis (GO:0060977)2.19670648
110myeloid cell development (GO:0061515)2.19311437
111regulation of glycogen (starch) synthase activity (GO:2000465)2.18895271
112gamma-aminobutyric acid transport (GO:0015812)2.18479972
113innervation (GO:0060384)2.18220862
114neuron recognition (GO:0008038)2.17080228
115peptidyl-threonine modification (GO:0018210)2.17011266
116histone H4-K12 acetylation (GO:0043983)2.16525487
117regulation of cAMP-dependent protein kinase activity (GO:2000479)2.16126816
118porphyrin-containing compound biosynthetic process (GO:0006779)2.16017601
119mating behavior (GO:0007617)2.15818762
120histone H3-K9 demethylation (GO:0033169)2.15284230
121histone demethylation (GO:0016577)2.15094284
122regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.14873895
123inner ear receptor cell development (GO:0060119)2.14194380
124heme transport (GO:0015886)2.12916284
125prepulse inhibition (GO:0060134)2.12819939
126response to methylmercury (GO:0051597)2.11675469
127positive regulation of erythrocyte differentiation (GO:0045648)2.11594336
128very-low-density lipoprotein particle assembly (GO:0034379)2.11435551
129establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.11163867
130mitochondrion transport along microtubule (GO:0047497)2.11163867
131synaptonemal complex assembly (GO:0007130)2.10630031
132nerve growth factor signaling pathway (GO:0038180)2.10605544
133synaptic vesicle maturation (GO:0016188)2.10254985
134protein-DNA complex disassembly (GO:0032986)2.09984186
135nucleosome disassembly (GO:0006337)2.09984186
136genetic imprinting (GO:0071514)2.09619200
137regulation of glycogen biosynthetic process (GO:0005979)2.09129471
138regulation of glucan biosynthetic process (GO:0010962)2.09129471
139histone H4-K16 acetylation (GO:0043984)2.08180707
140neuron projection extension (GO:1990138)2.08052255
141vocalization behavior (GO:0071625)2.08033421
142positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.07880281
143proline transport (GO:0015824)2.07159980
144type B pancreatic cell development (GO:0003323)2.07132906
145complement activation, alternative pathway (GO:0006957)2.06983704
146regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.06929186
147negative regulation of fatty acid metabolic process (GO:0045922)2.05093512
148neurotransmitter secretion (GO:0007269)2.04487759
149granulocyte differentiation (GO:0030851)2.04310920
150regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.04095880
151nucleus localization (GO:0051647)2.04058646
152regulation of synaptic vesicle exocytosis (GO:2000300)2.03815505
153protein-lipid complex assembly (GO:0065005)2.03743227
154ectodermal placode formation (GO:0060788)2.03533663
155activation of protein kinase A activity (GO:0034199)2.03209154
156Rap protein signal transduction (GO:0032486)2.02917502
157positive regulation of dendritic spine morphogenesis (GO:0061003)2.01594889
158intestinal cholesterol absorption (GO:0030299)2.01110678
159regulation of polysaccharide biosynthetic process (GO:0032885)2.00297022
160establishment of mitochondrion localization (GO:0051654)1.99489342
161embryonic hemopoiesis (GO:0035162)1.99409560
162mRNA splice site selection (GO:0006376)1.99298053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human3.55221624
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90344081
3EZH2_22144423_ChIP-Seq_EOC_Human2.74943022
4GATA1_19941826_ChIP-Seq_K562_Human2.74118496
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41702898
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34492660
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23767171
8TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.20376067
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.14062479
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03634121
11GATA2_19941826_ChIP-Seq_K562_Human2.01454948
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96371343
13WT1_19549856_ChIP-ChIP_CCG9911_Human1.91885885
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85123690
15RARB_27405468_Chip-Seq_BRAIN_Mouse1.82386910
16DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.81655986
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77162205
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72402104
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71147084
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70792674
21* KDM2B_26808549_Chip-Seq_K562_Human1.69745508
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67594850
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63027043
24FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.55119148
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54339505
26KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.52523778
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51121785
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50137317
29DROSHA_22980978_ChIP-Seq_HELA_Human1.48598147
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48473669
31GBX2_23144817_ChIP-Seq_PC3_Human1.48298177
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.46544693
33REST_21632747_ChIP-Seq_MESCs_Mouse1.46413010
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45665639
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45663205
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.45349001
37* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44926883
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43930705
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43848652
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.37301416
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36300601
42YAP1_20516196_ChIP-Seq_MESCs_Mouse1.35430345
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.35053656
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.33353736
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.33245770
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33186620
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.32450035
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32025311
49* RING1B_27294783_Chip-Seq_NPCs_Mouse1.31822895
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.31569853
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.31394867
52AR_21572438_ChIP-Seq_LNCaP_Human1.31330807
53* AR_19668381_ChIP-Seq_PC3_Human1.31059320
54AHR_22903824_ChIP-Seq_MCF-7_Human1.30950667
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30683251
56ZNF274_21170338_ChIP-Seq_K562_Hela1.28592491
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.28572566
58* STAT3_23295773_ChIP-Seq_U87_Human1.28403395
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.28356882
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.27493422
61* LXR_22158963_ChIP-Seq_LIVER_Mouse1.27376843
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27177389
63TP53_16413492_ChIP-PET_HCT116_Human1.26889710
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26840206
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25924495
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25650609
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24806069
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24786809
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24617287
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22455925
71* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21492256
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21077049
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.20364782
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20326391
75SMAD4_21799915_ChIP-Seq_A2780_Human1.20239590
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19347778
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18166552
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17985467
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17985467
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.17706590
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17572537
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17433251
83CLOCK_20551151_ChIP-Seq_293T_Human1.17414818
84SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16834910
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.16102955
86* KDM2B_26808549_Chip-Seq_JURKAT_Human1.15978009
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15711057
88JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15514624
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15314564
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14930385
91TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13834473
92IGF1R_20145208_ChIP-Seq_DFB_Human1.12928620
93TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12351189
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11030057
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09092493
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08975783
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08886846
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.08010087
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.07435167
100* KDM2B_26808549_Chip-Seq_DND41_Human1.07303038
101FOXA1_25552417_ChIP-Seq_VCAP_Human1.07234765
102JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07061102
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07052622
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.06504619
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05683554
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04948845
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04948845
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04744946
109* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04623017
110CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04496181
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04356292
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04192514
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04192514
114* TCF4_23295773_ChIP-Seq_U87_Human1.04145567
115RNF2_27304074_Chip-Seq_NSC_Mouse1.04007165
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02333229
117BCAT_22108803_ChIP-Seq_LS180_Human1.01617682
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01519451
119* RING1B_27294783_Chip-Seq_ESCs_Mouse1.01216329
120* TCF7_22412390_ChIP-Seq_EML_Mouse1.00352837
121EZH2_27304074_Chip-Seq_ESCs_Mouse0.99659487
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98698933
123* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98605868
124* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98254903
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98241732
126* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98223814
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98086871
128* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97792703
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96998226
130SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96978630
131FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96960169
132ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96401943
133* CREB1_26743006_Chip-Seq_LNCaP_Human0.95558689
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94445046
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94225934
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.94146334
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93883980
138GF1B_26923725_Chip-Seq_HPCs_Mouse0.93858499
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93764689
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93212167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo5.10394884
2MP0004147_increased_porphyrin_level3.75974235
3MP0005451_abnormal_body_composition3.62846364
4MP0003787_abnormal_imprinting3.45768723
5MP0002139_abnormal_hepatobiliary_system2.99622450
6MP0002009_preneoplasia2.70180903
7MP0009780_abnormal_chondrocyte_physiolo2.53677823
8MP0005409_darkened_coat_color2.50916949
9MP0004859_abnormal_synaptic_plasticity2.34328139
10MP0004145_abnormal_muscle_electrophysio2.34076171
11MP0005365_abnormal_bile_salt2.27798246
12MP0008877_abnormal_DNA_methylation2.23734727
13MP0002877_abnormal_melanocyte_morpholog2.19246666
14MP0005187_abnormal_penis_morphology2.16281435
15MP0008057_abnormal_DNA_replication2.15599898
16MP0002909_abnormal_adrenal_gland2.12689951
17MP0003890_abnormal_embryonic-extraembry2.12315013
18MP0004270_analgesia2.07360978
19MP0010234_abnormal_vibrissa_follicle2.06991620
20MP0004185_abnormal_adipocyte_glucose1.97826666
21MP0005076_abnormal_cell_differentiation1.97126017
22MP0005085_abnormal_gallbladder_physiolo1.93892692
23MP0003705_abnormal_hypodermis_morpholog1.93103602
24MP0009840_abnormal_foam_cell1.89083226
25MP0003252_abnormal_bile_duct1.83796276
26MP0003879_abnormal_hair_cell1.80083289
27MP0004036_abnormal_muscle_relaxation1.78274971
28MP0003119_abnormal_digestive_system1.73216940
29MP0004510_myositis1.72493578
30MP0003121_genomic_imprinting1.69690816
31MP0000778_abnormal_nervous_system1.67502976
32MP0008961_abnormal_basal_metabolism1.66837908
33MP0009703_decreased_birth_body1.61344564
34MP0000003_abnormal_adipose_tissue1.59882430
35MP0003868_abnormal_feces_composition1.58477763
36MP0003635_abnormal_synaptic_transmissio1.57820943
37MP0001944_abnormal_pancreas_morphology1.53922639
38MP0009672_abnormal_birth_weight1.52805326
39MP0008995_early_reproductive_senescence1.51188004
40MP0000569_abnormal_digit_pigmentation1.49721540
41MP0005666_abnormal_adipose_tissue1.48157134
42MP0005375_adipose_tissue_phenotype1.45649643
43MP0002332_abnormal_exercise_endurance1.44750882
44MP0002063_abnormal_learning/memory/cond1.43010489
45MP0000537_abnormal_urethra_morphology1.42555252
46MP0003300_gastrointestinal_ulcer1.40175136
47MP0001502_abnormal_circadian_rhythm1.39482321
48MP0003122_maternal_imprinting1.36084118
49MP0003221_abnormal_cardiomyocyte_apopto1.35987550
50MP0004084_abnormal_cardiac_muscle1.35198342
51MP0003646_muscle_fatigue1.34764112
52MP0003183_abnormal_peptide_metabolism1.32181330
53MP0002184_abnormal_innervation1.32028032
54MP0003303_peritoneal_inflammation1.29258949
55MP0002971_abnormal_brown_adipose1.28983774
56MP0000955_abnormal_spinal_cord1.28157821
57MP0001440_abnormal_grooming_behavior1.26301370
58MP0002234_abnormal_pharynx_morphology1.25983219
59MP0005397_hematopoietic_system_phenotyp1.25585329
60MP0001545_abnormal_hematopoietic_system1.25585329
61MP0006276_abnormal_autonomic_nervous1.23969289
62MP0006138_congestive_heart_failure1.23555232
63MP0005360_urolithiasis1.23439255
64MP0004858_abnormal_nervous_system1.20527666
65MP0005423_abnormal_somatic_nervous1.19999332
66MP0002896_abnormal_bone_mineralization1.19803239
67MP0010329_abnormal_lipoprotein_level1.18228638
68MP0003935_abnormal_craniofacial_develop1.18210497
69MP0008004_abnormal_stomach_pH1.18121467
70MP0004811_abnormal_neuron_physiology1.17955818
71MP0004087_abnormal_muscle_fiber1.17923557
72MP0003861_abnormal_nervous_system1.17749452
73MP0005220_abnormal_exocrine_pancreas1.17267276
74MP0000013_abnormal_adipose_tissue1.16951363
75MP0000462_abnormal_digestive_system1.16800299
76MP0003828_pulmonary_edema1.15335644
77MP0000759_abnormal_skeletal_muscle1.14943059
78MP0003123_paternal_imprinting1.14666900
79MP0004130_abnormal_muscle_cell1.14342649
80MP0002078_abnormal_glucose_homeostasis1.12831684
81MP0002822_catalepsy1.10743144
82MP0003191_abnormal_cellular_cholesterol1.09630056
83MP0003283_abnormal_digestive_organ1.08844720
84MP0004197_abnormal_fetal_growth/weight/1.08379681
85MP0003385_abnormal_body_wall1.06689444
86MP0002751_abnormal_autonomic_nervous1.05783439
87MP0005386_behavior/neurological_phenoty1.05386373
88MP0004924_abnormal_behavior1.05386373
89MP0005394_taste/olfaction_phenotype1.04934805
90MP0005499_abnormal_olfactory_system1.04934805
91MP0008789_abnormal_olfactory_epithelium1.03083984
92MP0001879_abnormal_lymphatic_vessel1.01767536
93MP0002152_abnormal_brain_morphology1.01502219
94MP0002084_abnormal_developmental_patter1.00908929
95MP0000678_abnormal_parathyroid_gland0.99902803
96MP0004885_abnormal_endolymph0.98688239
97MP0002837_dystrophic_cardiac_calcinosis0.98588061
98MP0000749_muscle_degeneration0.98400321
99MP0002557_abnormal_social/conspecific_i0.98219546
100MP0002106_abnormal_muscle_physiology0.98026655
101MP0000631_abnormal_neuroendocrine_gland0.97235646
102MP0002693_abnormal_pancreas_physiology0.96838716
103MP0006292_abnormal_olfactory_placode0.96242543
104MP0006072_abnormal_retinal_apoptosis0.96030941
105MP0002269_muscular_atrophy0.92713578
106MP0003195_calcinosis0.92372391
107MP0008438_abnormal_cutaneous_collagen0.92241426
108MP0001188_hyperpigmentation0.91822224
109MP0003045_fibrosis0.91736840
110MP0004233_abnormal_muscle_weight0.90933579
111MP0005620_abnormal_muscle_contractility0.90351440
112MP0001915_intracranial_hemorrhage0.90194134
113MP0002572_abnormal_emotion/affect_behav0.89832694
114MP0003755_abnormal_palate_morphology0.89781840
115MP0000747_muscle_weakness0.89667999
116MP0004264_abnormal_extraembryonic_tissu0.88924765
117MP0002697_abnormal_eye_size0.88178803
118MP0005670_abnormal_white_adipose0.86164449
119MP0002233_abnormal_nose_morphology0.84767101
120MP0005083_abnormal_biliary_tract0.84595601
121MP0002116_abnormal_craniofacial_bone0.82945058
122MP0009745_abnormal_behavioral_response0.82369417
123MP0003329_amyloid_beta_deposits0.81847134
124MP0000534_abnormal_ureter_morphology0.81739172
125MP0001270_distended_abdomen0.81264059
126MP0009250_abnormal_appendicular_skeleto0.80592422
127MP0002882_abnormal_neuron_morphology0.80052234
128MP0005248_abnormal_Harderian_gland0.79833061
129MP0005645_abnormal_hypothalamus_physiol0.79143951
130MP0002081_perinatal_lethality0.78900893
131MP0010630_abnormal_cardiac_muscle0.78628028
132MP0001299_abnormal_eye_distance/0.78470176
133MP0005367_renal/urinary_system_phenotyp0.77944846
134MP0000516_abnormal_urinary_system0.77944846
135MP0002734_abnormal_mechanical_nocicepti0.77514486
136MP0000609_abnormal_liver_physiology0.76536366
137MP0010352_gastrointestinal_tract_polyps0.75111952
138MP0003959_abnormal_lean_body0.74615079
139MP0005334_abnormal_fat_pad0.74553192
140MP0010368_abnormal_lymphatic_system0.74451545
141MP0000428_abnormal_craniofacial_morphol0.73906064
142MP0003115_abnormal_respiratory_system0.73568751
143MP0002127_abnormal_cardiovascular_syste0.71542724
144MP0003633_abnormal_nervous_system0.71448611
145MP0009931_abnormal_skin_appearance0.71221451
146MP0005369_muscle_phenotype0.69722320
147MP0002138_abnormal_hepatobiliary_system0.68982946
148MP0002085_abnormal_embryonic_tissue0.68354915
149MP0003937_abnormal_limbs/digits/tail_de0.67687455
150MP0002928_abnormal_bile_duct0.67179051
151MP0001666_abnormal_nutrient_absorption0.67035154
152MP0005257_abnormal_intraocular_pressure0.66832353
153MP0004215_abnormal_myocardial_fiber0.66419383
154MP0004043_abnormal_pH_regulation0.66321161
155MP0004085_abnormal_heartbeat0.66072662
156MP0003453_abnormal_keratinocyte_physiol0.65933881
157MP0005535_abnormal_body_temperature0.65873928
158MP0001784_abnormal_fluid_regulation0.65792512
159MP0003948_abnormal_gas_homeostasis0.64091958
160MP0002118_abnormal_lipid_homeostasis0.63977281
161MP0005266_abnormal_metabolism0.63369302
162MP0008770_decreased_survivor_rate0.62759818

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.98624763
2Poikilocytosis (HP:0004447)4.07773779
3Reticulocytosis (HP:0001923)3.35571590
4Exercise-induced myalgia (HP:0003738)3.28314156
5Volvulus (HP:0002580)3.26686047
6Acanthocytosis (HP:0001927)3.25977760
7Abnormality of the lower motor neuron (HP:0002366)3.25700897
8Difficulty running (HP:0009046)3.16880105
9Polycythemia (HP:0001901)3.07787825
10Macroorchidism (HP:0000053)3.02122253
11Elfin facies (HP:0004428)2.97217988
12Renovascular hypertension (HP:0100817)2.91286746
13Muscle fiber inclusion bodies (HP:0100299)2.84936783
14Hyperinsulinemic hypoglycemia (HP:0000825)2.79616891
15Termporal pattern (HP:0011008)2.74602487
16Insidious onset (HP:0003587)2.74602487
17Hyperacusis (HP:0010780)2.70758696
18Hyperventilation (HP:0002883)2.69049370
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.66372249
20Fetal akinesia sequence (HP:0001989)2.65294287
21Abnormal hemoglobin (HP:0011902)2.62267125
22Nemaline bodies (HP:0003798)2.62203687
23Long clavicles (HP:0000890)2.61563614
24Enlarged penis (HP:0000040)2.61143656
25Subacute progressive viral hepatitis (HP:0006572)2.57316241
26Osteomalacia (HP:0002749)2.53458546
27Type 1 muscle fiber predominance (HP:0003803)2.53280280
28Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.48835092
29Drooling (HP:0002307)2.48479585
30Excessive salivation (HP:0003781)2.48479585
31Insomnia (HP:0100785)2.47967684
32Papillary thyroid carcinoma (HP:0002895)2.43889171
33Hyperglycemia (HP:0003074)2.39950941
34Obsessive-compulsive behavior (HP:0000722)2.39197550
35Hepatoblastoma (HP:0002884)2.35458642
36Renal duplication (HP:0000075)2.34254721
37Hypoglycemic seizures (HP:0002173)2.28171311
38Truncal obesity (HP:0001956)2.26980593
39Hyperkalemia (HP:0002153)2.22395226
40Papilledema (HP:0001085)2.17451863
41Pelvic girdle muscle weakness (HP:0003749)2.15441980
42Astrocytoma (HP:0009592)2.15280493
43Abnormality of the astrocytes (HP:0100707)2.15280493
44Hyporeflexia of lower limbs (HP:0002600)2.14934178
45Exotropia (HP:0000577)2.14538612
46Abnormality of endocrine pancreas physiology (HP:0012093)2.14373809
47Abnormality of the pancreatic islet cells (HP:0006476)2.14373809
48Intrahepatic cholestasis (HP:0001406)2.12528342
49Pancreatic islet-cell hyperplasia (HP:0004510)2.12173009
50Complement deficiency (HP:0004431)2.10668250
51Dysmetric saccades (HP:0000641)2.10180005
52Exocrine pancreatic insufficiency (HP:0001738)2.09815152
53Peripheral hypomyelination (HP:0007182)2.09560987
54Insulin-resistant diabetes mellitus (HP:0000831)2.08219694
55Deep venous thrombosis (HP:0002625)2.06929147
56Hypochromic microcytic anemia (HP:0004840)2.06818383
57Overriding aorta (HP:0002623)2.06492883
58Neoplasm of the heart (HP:0100544)2.05640315
59Ketoacidosis (HP:0001993)2.01512793
60Hypsarrhythmia (HP:0002521)2.00256524
61Microcytic anemia (HP:0001935)1.99774289
62Hammertoe (HP:0001765)1.99624916
63Curly hair (HP:0002212)1.98849548
64Neurofibrillary tangles (HP:0002185)1.98479568
65Ketosis (HP:0001946)1.96507001
66Neoplasm of the tracheobronchial system (HP:0100552)1.96048433
67EEG with generalized epileptiform discharges (HP:0011198)1.95100257
68Impaired social interactions (HP:0000735)1.94829933
69Abnormal social behavior (HP:0012433)1.94829933
70Cortical dysplasia (HP:0002539)1.94337985
71Visceral angiomatosis (HP:0100761)1.93043408
72Back pain (HP:0003418)1.92370693
73Protruding tongue (HP:0010808)1.91107131
74Prolonged partial thromboplastin time (HP:0003645)1.89959080
75Hemangiomatosis (HP:0007461)1.88430403
76Epileptiform EEG discharges (HP:0011182)1.86778857
77Abnormality of the corticospinal tract (HP:0002492)1.86465343
78Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.86179532
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85781010
80Thickened helices (HP:0000391)1.84833973
81Generalized hypopigmentation of hair (HP:0011358)1.84712215
82Conjugated hyperbilirubinemia (HP:0002908)1.84677973
83Ependymoma (HP:0002888)1.83153774
84Subaortic stenosis (HP:0001682)1.82386493
85Abnormality of the left ventricular outflow tract (HP:0011103)1.82386493
86Transitional cell carcinoma of the bladder (HP:0006740)1.82056156
87Heterotopia (HP:0002282)1.81645360
88EMG: neuropathic changes (HP:0003445)1.81627956
89Sacral dimple (HP:0000960)1.81486759
90Cerebral inclusion bodies (HP:0100314)1.81459685
91Obstructive sleep apnea (HP:0002870)1.80982023
92Poor eye contact (HP:0000817)1.80919811
93Thyroid carcinoma (HP:0002890)1.80741843
94Open mouth (HP:0000194)1.80252417
95Bowel diverticulosis (HP:0005222)1.78226030
96Cerebral aneurysm (HP:0004944)1.78007854
97Acute myeloid leukemia (HP:0004808)1.77982859
98Decreased motor nerve conduction velocity (HP:0003431)1.77417733
99Tetraparesis (HP:0002273)1.77322862
100Agitation (HP:0000713)1.77249318
101Hypoplastic labia majora (HP:0000059)1.77246482
102Muscle fiber splitting (HP:0003555)1.77135846
103Flat cornea (HP:0007720)1.75301579
104Fair hair (HP:0002286)1.75070454
105Sporadic (HP:0003745)1.73590473
106Abnormality of the musculature of the pelvis (HP:0001469)1.73505289
107Abnormality of the hip-girdle musculature (HP:0001445)1.73505289
108Increased nuchal translucency (HP:0010880)1.72071927
109Bladder carcinoma (HP:0002862)1.71213420
110Bladder neoplasm (HP:0009725)1.71213420
111Visual hallucinations (HP:0002367)1.70513422
112Germ cell neoplasia (HP:0100728)1.70384376
113Frequent falls (HP:0002359)1.70080679
114Epidermoid cyst (HP:0200040)1.69838546
115Cubitus valgus (HP:0002967)1.69743135
116Genetic anticipation (HP:0003743)1.69287806
117Flat acetabular roof (HP:0003180)1.68472857
118Pointed chin (HP:0000307)1.67623838
119Hyperthyroidism (HP:0000836)1.67548363
120Shoulder girdle muscle weakness (HP:0003547)1.67373626
121Autoamputation (HP:0001218)1.67008659
122Broad ribs (HP:0000885)1.66767732
123Atelectasis (HP:0100750)1.66231781
124Foot dorsiflexor weakness (HP:0009027)1.66037921
125Febrile seizures (HP:0002373)1.65686905
126Abnormality of monocarboxylic acid metabolism (HP:0010996)1.65586949
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65031048
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.64574182
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.64574182
130Leiomyosarcoma (HP:0100243)1.64521884
131Uterine leiomyosarcoma (HP:0002891)1.64521884
132Exostoses (HP:0100777)1.63806182
133Deep palmar crease (HP:0006191)1.63583234
134Rimmed vacuoles (HP:0003805)1.63293438
135Supranuclear gaze palsy (HP:0000605)1.63284900
136Abnormality of the diencephalon (HP:0010662)1.63271640
137Vertebral arch anomaly (HP:0008438)1.62441509
138Fatigue (HP:0012378)1.62435855
139Focal motor seizures (HP:0011153)1.62242447
140Hypercortisolism (HP:0001578)1.61889033
141Cystic hygroma (HP:0000476)1.61744624
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.60748485
143Neonatal hypoglycemia (HP:0001998)1.60729986
144Abnormality of the foot musculature (HP:0001436)1.60574603
145Absent speech (HP:0001344)1.60439572
146Thick eyebrow (HP:0000574)1.59742986
147Cholelithiasis (HP:0001081)1.58994064
148Mask-like facies (HP:0000298)1.58884240
149Epileptic encephalopathy (HP:0200134)1.58496569
150Abnormality of the labia majora (HP:0012881)1.58345877
151Exercise-induced muscle cramps (HP:0003710)1.58234252
152Alveolar cell carcinoma (HP:0006519)1.57993372
153Apathy (HP:0000741)1.57930445
154Hypoglycemic coma (HP:0001325)1.57851936
155Spontaneous abortion (HP:0005268)1.57753657
156Abnormality of the common coagulation pathway (HP:0010990)1.57552274
157Action tremor (HP:0002345)1.57110610
158Neoplasm of the thyroid gland (HP:0100031)1.56656018
159Lymphangioma (HP:0100764)1.56398549
160Amyotrophic lateral sclerosis (HP:0007354)1.56181984
161Fat malabsorption (HP:0002630)1.55678155
162Abnormality of the fingertips (HP:0001211)1.55572847
163Abnormality of aromatic amino acid family metabolism (HP:0004338)1.55045222
164Focal seizures (HP:0007359)1.54614988
165Overgrowth (HP:0001548)1.52708820
166Gastrointestinal carcinoma (HP:0002672)1.52687212
167Malignant gastrointestinal tract tumors (HP:0006749)1.52687212
168Spina bifida occulta (HP:0003298)1.52601150
169Labial hypoplasia (HP:0000066)1.51905458
170Inappropriate behavior (HP:0000719)1.51641200
171Relative macrocephaly (HP:0004482)1.51612916
172Precocious puberty (HP:0000826)1.51463388
173Renal cell carcinoma (HP:0005584)1.50149970
174Neoplasm of the adrenal cortex (HP:0100641)1.49953170
175Hypoplastic ischia (HP:0003175)1.49677027
176Glioma (HP:0009733)1.49413529
177Impaired smooth pursuit (HP:0007772)1.49134399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.53078083
2MARK12.89097663
3CASK2.61865887
4MAP3K42.38461098
5PRPF4B2.37389778
6CDK122.29612440
7PKN22.26967281
8ERBB32.21453791
9TRIB32.21074964
10LATS12.16160828
11ICK2.04025422
12NTRK32.01358429
13OBSCN1.92221612
14PDGFRA1.86864058
15MAP3K21.84207298
16MAP3K91.82331444
17BRD41.70042472
18MAP3K101.67576527
19TYRO31.64774702
20RET1.61798333
21CAMK1G1.59914076
22PTK61.59854235
23STK241.51985048
24EPHA31.49058182
25MAP2K41.47075732
26MAP3K61.37856152
27PRKD31.36764522
28MAP3K51.36426444
29SIK11.33629535
30FGFR21.33542614
31ALK1.33187142
32SIK21.32922828
33MAPK121.32285449
34PNCK1.28323433
35KSR11.26185025
36PIK3CG1.25593841
37HIPK21.21896549
38STK31.19378264
39MTOR1.18346526
40FRK1.15414760
41SCYL21.14136661
42DAPK21.11483628
43TNIK1.11182859
44SGK31.11067603
45CAMK1D1.10593565
46NTRK21.06004549
47LATS21.04109261
48MAP3K71.01079654
49RIPK11.00740228
50SGK10.98995513
51MARK20.98642966
52MAP3K10.98382716
53DYRK1B0.94195210
54RPS6KA20.92174445
55PDGFRB0.92102283
56TRPM70.91609420
57MAP2K70.90974013
58RAF10.90936793
59STK110.87417159
60CDC70.86459859
61TAOK30.86277374
62FGFR30.85719254
63PRKAA20.85392270
64PLK40.84115292
65PLK20.83527561
66AKT30.80358054
67PAK30.80021645
68DMPK0.77633025
69CDK60.77068560
70CDK90.76721763
71MINK10.75733133
72PTK20.75571361
73NLK0.75464444
74SGK20.75365998
75MAPK130.74945196
76MAP2K10.74544203
77NTRK10.74217514
78KSR20.73550004
79BRAF0.72617900
80TAOK10.71333269
81PAK60.71199274
82EIF2AK10.70407344
83PRKAA10.70348502
84RPS6KB10.70323410
85UHMK10.70109528
86DYRK30.69666385
87WNK30.68214316
88DDR20.68141328
89CAMK40.67115771
90EPHB10.66973906
91WNK10.66254357
92EEF2K0.65991125
93DYRK1A0.64905296
94MAP2K20.63751208
95PINK10.63742969
96CSNK1A1L0.63501185
97DYRK20.63283049
98CSNK1G20.62924377
99NEK20.61340713
100MAP2K30.61295156
101PASK0.60450589
102EPHA40.59623885
103MATK0.59618541
104CDC42BPA0.59592776
105ERBB40.59227231
106CSNK1E0.58664288
107CDK50.57781745
108CAMKK10.57587381
109MAPK100.57347968
110STK380.56154301
111ERBB20.55291419
112GSK3B0.55286297
113FGFR40.54330457
114FGFR10.54073364
115MAPK140.51280409
116FLT30.50515010
117CSNK1D0.50072963
118PHKG10.50006601
119PHKG20.50006601
120ACVR1B0.49717367
121EPHB20.48983519
122RPS6KA30.48873028
123SGK2230.47519308
124SGK4940.47519308
125CDK20.47085334
126PRKCH0.46829204
127JAK20.45775767
128MAPK80.45041060
129MAPK40.44605862
130TTN0.44037342
131STK38L0.43611848
132MAPK90.41092439
133SIK30.41027690
134YES10.40779683
135PRKG10.40553604
136CLK10.40423490
137CHUK0.35179108
138MAP3K30.34988469
139PRKCZ0.34957752
140MAPK10.34435115

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.59048339
2Type II diabetes mellitus_Homo sapiens_hsa049302.02391017
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00405456
4Nitrogen metabolism_Homo sapiens_hsa009101.96236802
5Lysine degradation_Homo sapiens_hsa003101.88848369
6Insulin secretion_Homo sapiens_hsa049111.60537802
7Endometrial cancer_Homo sapiens_hsa052131.59872675
8Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59200978
9mTOR signaling pathway_Homo sapiens_hsa041501.56771074
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51092623
11Long-term potentiation_Homo sapiens_hsa047201.47965960
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44942920
13Acute myeloid leukemia_Homo sapiens_hsa052211.41244364
14Arginine biosynthesis_Homo sapiens_hsa002201.39880391
15Amphetamine addiction_Homo sapiens_hsa050311.37471751
16Dorso-ventral axis formation_Homo sapiens_hsa043201.37151319
17Glucagon signaling pathway_Homo sapiens_hsa049221.36601372
18Longevity regulating pathway - mammal_Homo sapiens_hsa042111.35776117
19Dopaminergic synapse_Homo sapiens_hsa047281.35516171
20Glioma_Homo sapiens_hsa052141.33663684
21Complement and coagulation cascades_Homo sapiens_hsa046101.30679468
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25006982
23Estrogen signaling pathway_Homo sapiens_hsa049151.24022249
24Insulin signaling pathway_Homo sapiens_hsa049101.23908808
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20140950
26AMPK signaling pathway_Homo sapiens_hsa041521.19903288
27Insulin resistance_Homo sapiens_hsa049311.19878011
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19457848
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18419965
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.17144410
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15860091
32Circadian entrainment_Homo sapiens_hsa047131.15721658
33GABAergic synapse_Homo sapiens_hsa047271.15618894
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14789201
35ErbB signaling pathway_Homo sapiens_hsa040121.14425299
36Cocaine addiction_Homo sapiens_hsa050301.11071255
37Inositol phosphate metabolism_Homo sapiens_hsa005621.10117431
38B cell receptor signaling pathway_Homo sapiens_hsa046621.09512715
39Glutamatergic synapse_Homo sapiens_hsa047241.09413543
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07528089
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07143687
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05182941
43Non-small cell lung cancer_Homo sapiens_hsa052231.05030880
44Cholinergic synapse_Homo sapiens_hsa047251.04957976
45Chronic myeloid leukemia_Homo sapiens_hsa052201.04567168
46Colorectal cancer_Homo sapiens_hsa052101.04315099
47Tryptophan metabolism_Homo sapiens_hsa003801.04013307
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01127473
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00177990
50Bile secretion_Homo sapiens_hsa049760.99841879
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98484561
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98436423
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98201215
54Nicotine addiction_Homo sapiens_hsa050330.97243734
55Hippo signaling pathway_Homo sapiens_hsa043900.95994130
56Axon guidance_Homo sapiens_hsa043600.95858469
57GnRH signaling pathway_Homo sapiens_hsa049120.95784421
58Caffeine metabolism_Homo sapiens_hsa002320.95364642
59Wnt signaling pathway_Homo sapiens_hsa043100.94687017
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.93605295
61FoxO signaling pathway_Homo sapiens_hsa040680.92293390
62Adherens junction_Homo sapiens_hsa045200.90824251
63Prolactin signaling pathway_Homo sapiens_hsa049170.90804852
64Taste transduction_Homo sapiens_hsa047420.90177172
65Selenocompound metabolism_Homo sapiens_hsa004500.89905049
66Morphine addiction_Homo sapiens_hsa050320.88737536
67Gap junction_Homo sapiens_hsa045400.88526735
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88498074
69Starch and sucrose metabolism_Homo sapiens_hsa005000.87834915
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.87690729
71Hedgehog signaling pathway_Homo sapiens_hsa043400.85968866
72Oxytocin signaling pathway_Homo sapiens_hsa049210.85941565
73Long-term depression_Homo sapiens_hsa047300.85703963
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85361271
75Renin secretion_Homo sapiens_hsa049240.85300379
76Melanogenesis_Homo sapiens_hsa049160.84951397
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.83948862
78Amoebiasis_Homo sapiens_hsa051460.82297856
79Olfactory transduction_Homo sapiens_hsa047400.82141518
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80706086
81Circadian rhythm_Homo sapiens_hsa047100.80205584
82MicroRNAs in cancer_Homo sapiens_hsa052060.78393178
83Renal cell carcinoma_Homo sapiens_hsa052110.77756835
84Thyroid hormone synthesis_Homo sapiens_hsa049180.77701911
85Prostate cancer_Homo sapiens_hsa052150.77445308
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.77374300
87mRNA surveillance pathway_Homo sapiens_hsa030150.77256211
88Synaptic vesicle cycle_Homo sapiens_hsa047210.77214292
89VEGF signaling pathway_Homo sapiens_hsa043700.74969806
90Basal cell carcinoma_Homo sapiens_hsa052170.74927259
91Butanoate metabolism_Homo sapiens_hsa006500.74235878
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74039883
93cAMP signaling pathway_Homo sapiens_hsa040240.72285363
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71812196
95Alcoholism_Homo sapiens_hsa050340.68710003
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66929544
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66835857
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66807543
99Choline metabolism in cancer_Homo sapiens_hsa052310.66635529
100MAPK signaling pathway_Homo sapiens_hsa040100.65735646
101Bladder cancer_Homo sapiens_hsa052190.65646546
102Pancreatic cancer_Homo sapiens_hsa052120.65130036
103Sphingolipid metabolism_Homo sapiens_hsa006000.64005262
104Dilated cardiomyopathy_Homo sapiens_hsa054140.63991099
105Thyroid cancer_Homo sapiens_hsa052160.63833130
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.62794239
107PPAR signaling pathway_Homo sapiens_hsa033200.62250438
108Oocyte meiosis_Homo sapiens_hsa041140.61953632
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61849667
110Gastric acid secretion_Homo sapiens_hsa049710.60989960
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60955079
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60856565
113ABC transporters_Homo sapiens_hsa020100.60079477
114HIF-1 signaling pathway_Homo sapiens_hsa040660.59392373
115Fatty acid biosynthesis_Homo sapiens_hsa000610.59088450
116Fat digestion and absorption_Homo sapiens_hsa049750.58807121
117Proteoglycans in cancer_Homo sapiens_hsa052050.58749150
118Ovarian steroidogenesis_Homo sapiens_hsa049130.58728626
119Retinol metabolism_Homo sapiens_hsa008300.57812694
120Focal adhesion_Homo sapiens_hsa045100.56895768
121Phenylalanine metabolism_Homo sapiens_hsa003600.55508017
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54754281
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.54343936
124Platelet activation_Homo sapiens_hsa046110.54101774
125Pancreatic secretion_Homo sapiens_hsa049720.53380310
126Hepatitis C_Homo sapiens_hsa051600.52955950
127Prion diseases_Homo sapiens_hsa050200.52553018
128Protein digestion and absorption_Homo sapiens_hsa049740.50064657
129Serotonergic synapse_Homo sapiens_hsa047260.47051759

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