TMEM59

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.81436532
2COPI coating of Golgi vesicle (GO:0048205)5.81436532
3signal peptide processing (GO:0006465)5.01430211
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.29637478
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.15413947
6L-phenylalanine catabolic process (GO:0006559)4.15413947
7protein retention in ER lumen (GO:0006621)4.09805843
8fatty acid elongation (GO:0030497)3.89475536
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.82337097
10L-phenylalanine metabolic process (GO:0006558)3.82337097
11nucleotide transmembrane transport (GO:1901679)3.78121480
12COPII vesicle coating (GO:0048208)3.67885455
13macroautophagy (GO:0016236)3.61930952
14negative regulation of complement activation (GO:0045916)3.44559425
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.33985473
16axonemal dynein complex assembly (GO:0070286)3.31253727
17xenobiotic catabolic process (GO:0042178)3.26114214
18negative regulation of humoral immune response (GO:0002921)3.22855046
19cellular ketone body metabolic process (GO:0046950)3.19749615
20negative regulation of protein activation cascade (GO:2000258)3.19096015
21peptide hormone processing (GO:0016486)3.17239091
22ethanol oxidation (GO:0006069)3.11719302
23retinol metabolic process (GO:0042572)3.03442400
24endocrine pancreas development (GO:0031018)3.03343342
25positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.01113794
26phenylpropanoid metabolic process (GO:0009698)3.00745320
27ketone body metabolic process (GO:1902224)2.99640996
28ER overload response (GO:0006983)2.98305775
29long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.97375114
30epoxygenase P450 pathway (GO:0019373)2.96180963
31central nervous system myelination (GO:0022010)2.94057883
32axon ensheathment in central nervous system (GO:0032291)2.94057883
33regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.92586039
34virion attachment to host cell (GO:0019062)2.90339745
35adhesion of symbiont to host cell (GO:0044650)2.90339745
36branched-chain amino acid catabolic process (GO:0009083)2.88939289
37sphingomyelin metabolic process (GO:0006684)2.88433648
38very long-chain fatty acid metabolic process (GO:0000038)2.87511308
39toxin metabolic process (GO:0009404)2.86137621
40response to misfolded protein (GO:0051788)2.84950197
41sulfur amino acid catabolic process (GO:0000098)2.83494589
42nucleotide transport (GO:0006862)2.82463303
43ethanol metabolic process (GO:0006067)2.82288266
44protein maturation by protein folding (GO:0022417)2.82230329
45amyloid precursor protein catabolic process (GO:0042987)2.81213087
46aromatic amino acid family catabolic process (GO:0009074)2.80241140
47ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.79082187
48fatty-acyl-CoA biosynthetic process (GO:0046949)2.79001138
49angiotensin maturation (GO:0002003)2.78888399
50cilium movement (GO:0003341)2.78526630
51cilium or flagellum-dependent cell motility (GO:0001539)2.77960069
52pyrimidine-containing compound transmembrane transport (GO:0072531)2.76452556
53acyl-CoA biosynthetic process (GO:0071616)2.73433525
54thioester biosynthetic process (GO:0035384)2.73433525
55GDP-mannose metabolic process (GO:0019673)2.72380604
56positive regulation of insulin secretion (GO:0032024)2.70088187
57peptide metabolic process (GO:0006518)2.69607423
58primary alcohol metabolic process (GO:0034308)2.69427797
59keratan sulfate catabolic process (GO:0042340)2.67699143
60fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.66099702
613-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.64813048
62purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.64813048
63oligosaccharide catabolic process (GO:0009313)2.64310135
64negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.64296005
65epithelial cilium movement (GO:0003351)2.63437620
66branched-chain amino acid metabolic process (GO:0009081)2.62352669
67adhesion of symbiont to host (GO:0044406)2.60745291
68axoneme assembly (GO:0035082)2.60134109
69L-ascorbic acid metabolic process (GO:0019852)2.59003697
70peptide catabolic process (GO:0043171)2.57656958
71glandular epithelial cell differentiation (GO:0002067)2.56826286
72drug transmembrane transport (GO:0006855)2.54206373
73ER to Golgi vesicle-mediated transport (GO:0006888)2.53917512
74detection of calcium ion (GO:0005513)2.48900178
75regulation of cholesterol biosynthetic process (GO:0045540)2.48572799
76positive regulation of glycolytic process (GO:0045821)2.48156902
77regulation of extracellular matrix disassembly (GO:0010715)2.47749646
78fatty-acyl-CoA metabolic process (GO:0035337)2.47244708
79cholesterol biosynthetic process (GO:0006695)2.47206828
80exogenous drug catabolic process (GO:0042738)2.46100346
81vesicle coating (GO:0006901)2.45686180
82long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.45557860
83insulin secretion (GO:0030073)2.45212081
84purine ribonucleotide transport (GO:0015868)2.45094512
85transcytosis (GO:0045056)2.45058403
86glyoxylate metabolic process (GO:0046487)2.44839571
87positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.43840844
88sequestering of metal ion (GO:0051238)2.43395332
89nucleotide-sugar biosynthetic process (GO:0009226)2.42311849
90alpha-linolenic acid metabolic process (GO:0036109)2.42309358
91amyloid precursor protein metabolic process (GO:0042982)2.42189943
92response to redox state (GO:0051775)2.41649593
93water-soluble vitamin biosynthetic process (GO:0042364)2.41542282
94exocrine pancreas development (GO:0031017)2.40900513
95regulation of cholesterol metabolic process (GO:0090181)2.40809533
96drug catabolic process (GO:0042737)2.40769447
97glutathione biosynthetic process (GO:0006750)2.40417641
98positive regulation of peptide hormone secretion (GO:0090277)2.40411279
99regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.39922033
100positive regulation of cellular amine metabolic process (GO:0033240)2.39830637
101carbohydrate derivative transport (GO:1901264)2.38638496
102fatty acid beta-oxidation (GO:0006635)2.38178102
103primary alcohol catabolic process (GO:0034310)2.38147922
104eosinophil chemotaxis (GO:0048245)2.37812149
105fatty acid catabolic process (GO:0009062)2.37711900
106drug metabolic process (GO:0017144)2.36924137
107aldehyde catabolic process (GO:0046185)2.36732356
108nitric oxide biosynthetic process (GO:0006809)2.36709284
109peroxisome fission (GO:0016559)2.36513543
110short-chain fatty acid metabolic process (GO:0046459)2.36171059
111cellular glucuronidation (GO:0052695)2.34802624
112valine metabolic process (GO:0006573)2.34041971
113lipid oxidation (GO:0034440)2.32579032
114ferric iron transport (GO:0015682)2.32380166
115trivalent inorganic cation transport (GO:0072512)2.32380166
116polyketide metabolic process (GO:0030638)2.32323282
117doxorubicin metabolic process (GO:0044598)2.32323282
118daunorubicin metabolic process (GO:0044597)2.32323282
119transferrin transport (GO:0033572)2.32206200
120pH reduction (GO:0045851)2.31884891
121regulation of glucokinase activity (GO:0033131)2.31503570
122regulation of hexokinase activity (GO:1903299)2.31503570
123regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.31411400
124positive regulation of peptide secretion (GO:0002793)2.30617170
125nitric oxide mediated signal transduction (GO:0007263)2.30507521
126nonribosomal peptide biosynthetic process (GO:0019184)2.29517059
127fatty acid oxidation (GO:0019395)2.29270706
128regulation of type B pancreatic cell apoptotic process (GO:2000674)2.29167268
129response to mercury ion (GO:0046689)2.28814276
130regulation of metalloenzyme activity (GO:0048552)2.28785530
131fucose metabolic process (GO:0006004)2.28021554
132L-serine transport (GO:0015825)2.27584677
133positive regulation of calcium ion import (GO:0090280)2.27495098
134cysteine metabolic process (GO:0006534)2.27216091
135acyl-CoA metabolic process (GO:0006637)2.26151618
136thioester metabolic process (GO:0035383)2.26151618
137epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.25766172
138peroxisome organization (GO:0007031)2.25738578
139calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.24615969
140protein N-linked glycosylation via asparagine (GO:0018279)2.24033232
141bile acid metabolic process (GO:0008206)2.23738780
142negative regulation of hormone metabolic process (GO:0032351)2.22719190
143regulation of autophagic vacuole assembly (GO:2000785)2.22451756
144regulation of complement activation (GO:0030449)2.22424446
145S-adenosylmethionine metabolic process (GO:0046500)2.22108095
146diterpenoid biosynthetic process (GO:0016102)2.21669769
147bile acid biosynthetic process (GO:0006699)2.21466421
148coenzyme catabolic process (GO:0009109)2.21233472
149sphingolipid catabolic process (GO:0030149)2.20978372
150glutathione metabolic process (GO:0006749)2.20448609
151activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.19273243
152mannosylation (GO:0097502)2.19153418
153peptidyl-asparagine modification (GO:0018196)2.19083420
154magnesium ion transport (GO:0015693)2.18908588
155regulation of protein activation cascade (GO:2000257)2.18809154
156succinate metabolic process (GO:0006105)2.18158262
157uronic acid metabolic process (GO:0006063)2.17786997
158glucuronate metabolic process (GO:0019585)2.17786997
159tricarboxylic acid metabolic process (GO:0072350)2.17698129
160retinal metabolic process (GO:0042574)2.17666752
161monocarboxylic acid catabolic process (GO:0072329)2.17236987
162glutathione derivative biosynthetic process (GO:1901687)2.17165867
163glutathione derivative metabolic process (GO:1901685)2.17165867
164positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.16789819
165auditory receptor cell differentiation (GO:0042491)2.16027498
166hormone metabolic process (GO:0042445)2.13799856
167aminoglycoside antibiotic metabolic process (GO:0030647)2.12774812
168beta-amyloid metabolic process (GO:0050435)2.12693195
169membrane lipid catabolic process (GO:0046466)2.12025624
170amino-acid betaine metabolic process (GO:0006577)2.10894383
171eosinophil migration (GO:0072677)2.10663942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.28385074
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.26770094
3* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.87337013
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.78624387
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.63676102
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.59315397
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.45041622
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43571285
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.37309497
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20003257
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.13494273
12CLOCK_20551151_ChIP-Seq_293T_Human2.11439108
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09710137
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.09482419
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03443144
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92673194
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.86794452
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77538436
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.70574555
20* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69456688
21SOX2_20726797_ChIP-Seq_SW620_Human1.69285043
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67114745
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62922602
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61001694
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61001694
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57456476
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54274261
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48963714
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.46854545
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42652522
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.37864928
32HTT_18923047_ChIP-ChIP_STHdh_Human1.37267893
33CDX2_20551321_ChIP-Seq_CACO-2_Human1.36801401
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36228803
35CDX2_22108803_ChIP-Seq_LS180_Human1.34662638
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34398838
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.32898710
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30516292
39* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.30196877
40SMAD4_21799915_ChIP-Seq_A2780_Human1.29134881
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28543456
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24681988
43GATA1_22025678_ChIP-Seq_K562_Human1.24032494
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.23495206
45BCAT_22108803_ChIP-Seq_LS180_Human1.23299258
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.21207824
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19594447
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18494932
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18214703
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17790616
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17124877
52* FOXA1_25329375_ChIP-Seq_VCAP_Human1.15480706
53* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15480706
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15285253
55VDR_22108803_ChIP-Seq_LS180_Human1.15197040
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15012293
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14815539
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14611036
59AR_25329375_ChIP-Seq_VCAP_Human1.14447160
60* GABP_17652178_ChIP-ChIP_JURKAT_Human1.13860859
61P300_19829295_ChIP-Seq_ESCs_Human1.13821248
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.13619320
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.12553832
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11161007
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10928151
66P53_22387025_ChIP-Seq_ESCs_Mouse1.10644709
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08559437
68IGF1R_20145208_ChIP-Seq_DFB_Human1.08262141
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08206676
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07901042
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.07411722
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07368233
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06573866
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06274527
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05865036
76TP63_23658742_ChIP-Seq_EP156T_Human1.05352868
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05275968
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05160442
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05055113
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.03515487
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03354730
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.03062349
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01658702
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01624073
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.01228783
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.01099311
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.00221258
88EOMES_21245162_ChIP-Seq_HESCs_Human0.99906619
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99804341
90SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98245768
91ER_23166858_ChIP-Seq_MCF-7_Human0.98166229
92CTCF_18555785_Chip-Seq_ESCs_Mouse0.97894158
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97556691
94GATA4_25053715_ChIP-Seq_YYC3_Human0.96970998
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96826648
96TP53_18474530_ChIP-ChIP_U2OS_Human0.96804193
97* PHF8_20622853_ChIP-Seq_HELA_Human0.96570201
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.95122696
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94865033
100CBP_20019798_ChIP-Seq_JUKART_Human0.94865033
101TAL1_26923725_Chip-Seq_HPCs_Mouse0.94852159
102E2F1_18555785_Chip-Seq_ESCs_Mouse0.94835407
103* HNFA_21074721_ChIP-Seq_CACO-2_Human0.94775497
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94539630
105TCF4_22108803_ChIP-Seq_LS180_Human0.94355425
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94031656
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93988152
108* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93757980
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93613738
110AR_20517297_ChIP-Seq_VCAP_Human0.93080250
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92314071
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.92311021
113PU1_27457419_Chip-Seq_LIVER_Mouse0.91975853
114MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91452198
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91378027
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91143393
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91067682
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90782703
119CBP_21632823_ChIP-Seq_H3396_Human0.90439976
120GBX2_23144817_ChIP-Seq_PC3_Human0.90065583
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89980998
122FOXH1_21741376_ChIP-Seq_ESCs_Human0.89851591
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89487047
124* RBPJ_21746931_ChIP-Seq_IB4_Human0.89336816
125* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89076541
126* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87846878
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.87084417
128CTCF_20526341_ChIP-Seq_ESCs_Human0.84453459
129ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84151930
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83587210
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82903780
132CJUN_26792858_Chip-Seq_BT549_Human0.82466234
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82337946
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82277494
135FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82167014
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81953444
137JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.81730318
138GATA3_24758297_ChIP-Seq_MCF-7_Human0.81686496
139ERG_20517297_ChIP-Seq_VCAP_Human0.81378536
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81116681
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80497011
142REST_19997604_ChIP-ChIP_NEURONS_Mouse0.77838716
143TAF15_26573619_Chip-Seq_HEK293_Human0.77234603
144NANOG_19829295_ChIP-Seq_ESCs_Human0.76786882
145SOX2_19829295_ChIP-Seq_ESCs_Human0.76786882
146LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.76540397
147RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75561954
148SOX17_20123909_ChIP-Seq_XEN_Mouse0.74901535
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74513677
150CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73083154
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.72192284
152EP300_21415370_ChIP-Seq_HL-1_Mouse0.71214229
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.70865258
154ELK1_22589737_ChIP-Seq_MCF10A_Human0.70377844
155CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.69549759
156BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69346223
157TP63_17297297_ChIP-ChIP_HaCaT_Human0.68127930
158PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67446699
159EZH2_27294783_Chip-Seq_ESCs_Mouse0.66453007

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.09202867
2MP0002139_abnormal_hepatobiliary_system3.45708223
3MP0004043_abnormal_pH_regulation3.23967463
4MP0005365_abnormal_bile_salt2.99656577
5MP0000013_abnormal_adipose_tissue2.84202318
6MP0008875_abnormal_xenobiotic_pharmacok2.83832434
7MP0005058_abnormal_lysosome_morphology2.73973062
8MP0009840_abnormal_foam_cell2.64527603
9MP0005360_urolithiasis2.55351675
10MP0003806_abnormal_nucleotide_metabolis2.49789804
11MP0010234_abnormal_vibrissa_follicle2.36859557
12MP0005085_abnormal_gallbladder_physiolo2.34366090
13MP0003183_abnormal_peptide_metabolism2.32221963
14MP0005332_abnormal_amino_acid2.31802571
15MP0001666_abnormal_nutrient_absorption2.21750809
16MP0003329_amyloid_beta_deposits2.18261108
17MP0009780_abnormal_chondrocyte_physiolo2.14102119
18MP0010386_abnormal_urinary_bladder2.12864109
19MP0008438_abnormal_cutaneous_collagen2.10507703
20MP0005220_abnormal_exocrine_pancreas2.04667582
21MP0009643_abnormal_urine_homeostasis1.96953914
22MP0002909_abnormal_adrenal_gland1.83912143
23MP0006082_CNS_inflammation1.78486418
24MP0001542_abnormal_bone_strength1.71774803
25MP0003690_abnormal_glial_cell1.71571258
26MP0001756_abnormal_urination1.68524700
27MP0004019_abnormal_vitamin_homeostasis1.67212478
28MP0002876_abnormal_thyroid_physiology1.64869250
29MP0005084_abnormal_gallbladder_morpholo1.64323679
30MP0005083_abnormal_biliary_tract1.62419057
31MP0001944_abnormal_pancreas_morphology1.61921433
32MP0006054_spinal_hemorrhage1.61850762
33MP0003191_abnormal_cellular_cholesterol1.59258205
34MP0000920_abnormal_myelination1.57029639
35MP0005379_endocrine/exocrine_gland_phen1.54527151
36MP0003252_abnormal_bile_duct1.48594669
37MP0005636_abnormal_mineral_homeostasis1.47445250
38MP0010329_abnormal_lipoprotein_level1.45737432
39MP0000462_abnormal_digestive_system1.43425802
40MP0001765_abnormal_ion_homeostasis1.43183186
41MP0002118_abnormal_lipid_homeostasis1.42212735
42MP0002693_abnormal_pancreas_physiology1.41970063
43MP0000604_amyloidosis1.41518442
44MP0003186_abnormal_redox_activity1.41408236
45MP0001501_abnormal_sleep_pattern1.39547228
46MP0009384_cardiac_valve_regurgitation1.39011671
47MP0002295_abnormal_pulmonary_circulatio1.35068718
48MP0008260_abnormal_autophagy1.34535399
49MP0001984_abnormal_olfaction1.31974551
50MP0002877_abnormal_melanocyte_morpholog1.30647246
51MP0003172_abnormal_lysosome_physiology1.27895516
52MP0005408_hypopigmentation1.24664807
53MP0004215_abnormal_myocardial_fiber1.24197433
54MP0001661_extended_life_span1.22406654
55MP0005646_abnormal_pituitary_gland1.21663102
56MP0005503_abnormal_tendon_morphology1.21572433
57MP0000230_abnormal_systemic_arterial1.19499618
58MP0005275_abnormal_skin_tensile1.19439631
59MP0002078_abnormal_glucose_homeostasis1.16775591
60MP0004272_abnormal_basement_membrane1.15260606
61MP0004885_abnormal_endolymph1.12704158
62MP0000003_abnormal_adipose_tissue1.12629163
63MP0003283_abnormal_digestive_organ1.11525772
64MP0006036_abnormal_mitochondrial_physio1.10901326
65MP0002837_dystrophic_cardiac_calcinosis1.10837976
66MP0003075_altered_response_to1.10792839
67MP0003879_abnormal_hair_cell1.08455893
68MP0001958_emphysema1.08435860
69MP0000639_abnormal_adrenal_gland1.06977477
70MP0002896_abnormal_bone_mineralization1.06673625
71MP0009046_muscle_twitch1.06284927
72MP0000678_abnormal_parathyroid_gland1.05974623
73MP0003634_abnormal_glial_cell1.05724114
74MP0005165_increased_susceptibility_to1.05144545
75MP0005584_abnormal_enzyme/coenzyme_acti1.04155635
76MP0001664_abnormal_digestion1.03344250
77MP0001764_abnormal_homeostasis1.02639091
78MP0002138_abnormal_hepatobiliary_system0.98991954
79MP0005166_decreased_susceptibility_to0.97386979
80MP0003656_abnormal_erythrocyte_physiolo0.96359680
81MP0004782_abnormal_surfactant_physiolog0.96024552
82MP0000613_abnormal_salivary_gland0.95672895
83MP0000538_abnormal_urinary_bladder0.95557289
84MP0008004_abnormal_stomach_pH0.95252280
85MP0005551_abnormal_eye_electrophysiolog0.95002283
86MP0000681_abnormal_thyroid_gland0.94650614
87MP0003868_abnormal_feces_composition0.91265204
88MP0001905_abnormal_dopamine_level0.88984972
89MP0004270_analgesia0.88396921
90MP0005645_abnormal_hypothalamus_physiol0.88112493
91MP0001270_distended_abdomen0.86871304
92MP0005253_abnormal_eye_physiology0.86605064
93MP0003633_abnormal_nervous_system0.86225429
94MP0009785_altered_susceptibility_to0.86094482
95MP0000516_abnormal_urinary_system0.86055833
96MP0005367_renal/urinary_system_phenotyp0.86055833
97MP0005448_abnormal_energy_balance0.85131236
98MP0002090_abnormal_vision0.85097543
99MP0010678_abnormal_skin_adnexa0.84337787
100MP0003953_abnormal_hormone_level0.83255410
101MP0004264_abnormal_extraembryonic_tissu0.83106825
102MP0005319_abnormal_enzyme/_coenzyme0.81774572
103MP0008775_abnormal_heart_ventricle0.81395418
104MP0001986_abnormal_taste_sensitivity0.80457701
105MP0005075_abnormal_melanosome_morpholog0.78419125
106MP0003279_aneurysm0.77260160
107MP0005164_abnormal_response_to0.77115607
108MP0006072_abnormal_retinal_apoptosis0.76802187
109MP0000609_abnormal_liver_physiology0.76512142
110MP0004484_altered_response_of0.75885319
111MP0008469_abnormal_protein_level0.75580539
112MP0003866_abnormal_defecation0.74441145
113MP0001502_abnormal_circadian_rhythm0.74356890
114MP0005171_absent_coat_pigmentation0.73112455
115MP0002168_other_aberrant_phenotype0.73108112
116MP0003638_abnormal_response/metabolism_0.73002009
117MP0005535_abnormal_body_temperature0.71168487
118MP0005595_abnormal_vascular_smooth0.71025023
119MP0002971_abnormal_brown_adipose0.70327256
120MP0002136_abnormal_kidney_physiology0.68701973
121MP0002928_abnormal_bile_duct0.68306427
122MP0002277_abnormal_respiratory_mucosa0.68040555
123MP0009642_abnormal_blood_homeostasis0.65943715
124MP0001485_abnormal_pinna_reflex0.65861057
125MP0002229_neurodegeneration0.63623598
126MP0002638_abnormal_pupillary_reflex0.62699805
127MP0003724_increased_susceptibility_to0.62602039
128MP0003011_delayed_dark_adaptation0.62164454
129MP0002254_reproductive_system_inflammat0.62045134
130MP0004147_increased_porphyrin_level0.61194962

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.37570973
2Hypoglycemic coma (HP:0001325)4.32938280
3Hypoglycemic seizures (HP:0002173)4.00381849
4Generalized aminoaciduria (HP:0002909)3.86769736
5Symptomatic seizures (HP:0011145)3.74224965
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.73970952
7Hyperinsulinemic hypoglycemia (HP:0000825)3.45387420
8Vacuolated lymphocytes (HP:0001922)3.44947668
9Gout (HP:0001997)3.44782228
10Rhinitis (HP:0012384)3.36908758
11Abnormal respiratory epithelium morphology (HP:0012253)3.34438514
12Abnormal respiratory motile cilium morphology (HP:0005938)3.34438514
13Abnormal respiratory motile cilium physiology (HP:0012261)3.25376017
14Neurofibrillary tangles (HP:0002185)3.24897308
15Ketoacidosis (HP:0001993)3.22628739
16Dysostosis multiplex (HP:0000943)3.20524621
17Abnormal ciliary motility (HP:0012262)3.18339461
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.89765903
19Absent/shortened dynein arms (HP:0200106)2.89765903
20Abnormality of fatty-acid metabolism (HP:0004359)2.83512195
21Ketosis (HP:0001946)2.80028201
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.78089055
23Increased CSF protein (HP:0002922)2.70426226
24Progressive neurologic deterioration (HP:0002344)2.65857510
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.63991230
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63535476
27Abnormality of vitamin B metabolism (HP:0004340)2.62497555
28Intrahepatic cholestasis (HP:0001406)2.62080894
29Hypokalemic alkalosis (HP:0001949)2.60983936
30Abnormality of the intrinsic pathway (HP:0010989)2.59001450
31Hyperglycinuria (HP:0003108)2.58681452
32Hepatic necrosis (HP:0002605)2.56823528
33Abnormality of vitamin metabolism (HP:0100508)2.53549511
34Mucopolysacchariduria (HP:0008155)2.52451350
35Urinary glycosaminoglycan excretion (HP:0003541)2.52451350
36Abnormality of glycine metabolism (HP:0010895)2.50353670
37Abnormality of serine family amino acid metabolism (HP:0010894)2.50353670
38Xanthomatosis (HP:0000991)2.49712282
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.47095015
40Conjugated hyperbilirubinemia (HP:0002908)2.45286975
41Hyperglycinemia (HP:0002154)2.44877882
42Increased circulating renin level (HP:0000848)2.43686522
43Chronic bronchitis (HP:0004469)2.42904218
44Bronchiectasis (HP:0002110)2.41542974
45Neuroendocrine neoplasm (HP:0100634)2.40212711
46Pheochromocytoma (HP:0002666)2.39883187
47Protuberant abdomen (HP:0001538)2.38594306
48Congenital sensorineural hearing impairment (HP:0008527)2.38269908
49Hyperactive renin-angiotensin system (HP:0000841)2.35277439
50Vascular calcification (HP:0004934)2.31973023
51Late onset (HP:0003584)2.31577477
52Abnormality of urine glucose concentration (HP:0011016)2.31356351
53Glycosuria (HP:0003076)2.31356351
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31222132
55Dicarboxylic aciduria (HP:0003215)2.31222132
56Abnormality of proline metabolism (HP:0010907)2.29760295
57Hydroxyprolinuria (HP:0003080)2.29760295
58Hypokalemia (HP:0002900)2.28969592
59Fat malabsorption (HP:0002630)2.27537266
60Hyperglycemia (HP:0003074)2.23982434
61Abnormality of calcium-phosphate metabolism (HP:0100530)2.21701144
62Abnormality of polysaccharide metabolism (HP:0011012)2.20032051
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20032051
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20032051
65Large for gestational age (HP:0001520)2.19791572
66Abnormality of renin-angiotensin system (HP:0000847)2.18801662
67Malnutrition (HP:0004395)2.18690955
68Hypomagnesemia (HP:0002917)2.17928824
69Methylmalonic aciduria (HP:0012120)2.17770564
70Abnormality of purine metabolism (HP:0004352)2.17230635
71Hypoplasia of the uterus (HP:0000013)2.17149199
72Epiphyseal stippling (HP:0010655)2.16701319
73Loss of speech (HP:0002371)2.15492642
74Hyperlipoproteinemia (HP:0010980)2.14155101
75Abnormality of magnesium homeostasis (HP:0004921)2.12820460
76Cardiovascular calcification (HP:0011915)2.12081529
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.11880121
78Spastic paraparesis (HP:0002313)2.11605754
79Irritability (HP:0000737)2.10582684
80Retinal atrophy (HP:0001105)2.10061546
81Steatorrhea (HP:0002570)2.08388552
82Abnormality of liposaccharide metabolism (HP:0010968)2.07672249
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.07672249
84Abnormality of glycolipid metabolism (HP:0010969)2.07672249
85Tongue fasciculations (HP:0001308)2.07290372
86Hyperaldosteronism (HP:0000859)2.07123531
87Systemic lupus erythematosus (HP:0002725)2.06252528
88Proximal tubulopathy (HP:0000114)2.06060057
89Metaphyseal dysplasia (HP:0100255)2.05958718
90Renal salt wasting (HP:0000127)2.04394780
91Brushfield spots (HP:0001088)2.03765416
92Beaking of vertebral bodies (HP:0004568)2.01954360
93Acute encephalopathy (HP:0006846)2.01678856
94Alkalosis (HP:0001948)1.99779658
95Insulin-resistant diabetes mellitus (HP:0000831)1.99127240
96Aplasia/hypoplasia of the uterus (HP:0008684)1.98484874
97Lethargy (HP:0001254)1.96662913
98Prolonged partial thromboplastin time (HP:0003645)1.96307760
99Medial flaring of the eyebrow (HP:0010747)1.95750512
100Split foot (HP:0001839)1.95693379
101Abnormality of renal excretion (HP:0011036)1.93879078
102Hepatocellular necrosis (HP:0001404)1.93295107
103Palpitations (HP:0001962)1.92079972
104Hypothermia (HP:0002045)1.92040824
105Decreased circulating renin level (HP:0003351)1.91755433
106Abnormal protein glycosylation (HP:0012346)1.91352639
107Abnormal glycosylation (HP:0012345)1.91352639
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91352639
109Abnormal protein N-linked glycosylation (HP:0012347)1.91352639
110Hyperphosphatemia (HP:0002905)1.91175102
111Complement deficiency (HP:0004431)1.91106361
112Cerebral inclusion bodies (HP:0100314)1.90688846
113Increased cerebral lipofuscin (HP:0011813)1.90410937
114Metabolic alkalosis (HP:0200114)1.89310098
115Nasal polyposis (HP:0100582)1.88403506
116Abnormal urine output (HP:0012590)1.87203859
117Polyphagia (HP:0002591)1.86579314
118Abnormality of the vitamin B12 metabolism (HP:0004341)1.86097859
119Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85877618
120Postural tremor (HP:0002174)1.85407111
121Abnormal epiphyseal ossification (HP:0010656)1.84102730
122Syncope (HP:0001279)1.84091554
123Dysautonomia (HP:0002459)1.83895058
124Hyperuricemia (HP:0002149)1.83663421
125Increased purine levels (HP:0004368)1.83663421
126Chronic diarrhea (HP:0002028)1.83159994
127Abnormality of the common coagulation pathway (HP:0010990)1.83008257
128Abnormality of the pancreatic islet cells (HP:0006476)1.82957559
129Abnormality of endocrine pancreas physiology (HP:0012093)1.82957559
130Hypokinesia (HP:0002375)1.81752929
131Abnormal pancreas size (HP:0012094)1.81544657
132Polyuria (HP:0000103)1.81528599
133Hyperammonemia (HP:0001987)1.80159649
134Disproportionate short-trunk short stature (HP:0003521)1.80079033
135Methylmalonic acidemia (HP:0002912)1.79915100
136Premature rupture of membranes (HP:0001788)1.79714101
137Glomerulonephritis (HP:0000099)1.78543276
138Abnormality of the renal cortex (HP:0011035)1.77860366
139Abnormality of the nasal mucosa (HP:0000433)1.77626855
140Renal cortical cysts (HP:0000803)1.75351452
141Progressive macrocephaly (HP:0004481)1.73350407
142Muscle fibrillation (HP:0010546)1.72596182
143Growth hormone excess (HP:0000845)1.70973252
144Metabolic acidosis (HP:0001942)1.70775287
145Exocrine pancreatic insufficiency (HP:0001738)1.70688695
146Mitral stenosis (HP:0001718)1.68647068
147Hypotension (HP:0002615)1.65546850
148Tetraparesis (HP:0002273)1.65186347
149Acute necrotizing encephalopathy (HP:0006965)1.63051835
150Abnormal drinking behavior (HP:0030082)1.62763316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.90350569
2INSRR3.60523231
3BCKDK3.40232129
4WNK43.07657589
5STK392.94640425
6OXSR12.89613346
7ERN12.68337712
8STK162.34254653
9WNK32.29578738
10ACVR1B1.98567925
11MST41.90104329
12EPHB11.86066242
13MAP4K21.84611497
14BCR1.79930380
15NTRK11.78619955
16ARAF1.74894660
17EPHA21.72773275
18PASK1.72408163
19FRK1.67862049
20MAPKAPK31.67836512
21MET1.67338143
22PHKG11.60309672
23PHKG21.60309672
24SCYL21.57040751
25AKT31.55584685
26TRPM71.52986382
27PIK3CG1.46277954
28DAPK21.45033775
29TIE11.44468332
30MAP3K21.42908429
31MYLK1.42111735
32MAP2K61.40762657
33IRAK11.35735844
34BMPR1B1.30452377
35CASK1.28426495
36FLT31.27230086
37PAK31.20856814
38LIMK11.17034909
39CAMKK21.12418538
40MAP2K21.07937717
41TGFBR21.06210070
42TNIK1.04294216
43FGFR41.03899108
44NEK61.03861149
45PTK2B1.01665929
46EPHA31.01204714
47TAOK31.00116376
48PRKD30.99349898
49PTK20.98890118
50PDK20.96431877
51TBK10.96240639
52PRKCE0.94942645
53CAMK2G0.94623299
54HIPK20.93733898
55SGK2230.93349945
56SGK4940.93349945
57IRAK30.93147928
58CAMK2D0.92758241
59IRAK20.91333501
60STK240.91103719
61CAMK2B0.90732649
62FGFR30.88154500
63STK38L0.87825725
64CSNK1G30.86633342
65EIF2AK30.86502396
66MAP3K30.85981971
67FER0.85887003
68KIT0.85093241
69SIK10.82654647
70MAPKAPK50.80771325
71TYK20.80385283
72NTRK30.78420353
73ADRBK20.78248241
74MAP3K120.77486470
75PIM20.76619192
76CSNK1A1L0.75671569
77EIF2AK10.74430104
78DAPK10.73526641
79PINK10.73234125
80KDR0.72613597
81BMPR20.70195099
82MAP2K10.69720616
83CDK190.69371768
84JAK10.68228182
85PRKAA20.65878996
86TXK0.65323024
87CSNK1G10.64673313
88DAPK30.64553513
89LMTK20.64123032
90PBK0.64103627
91TESK10.64098140
92BRAF0.63592416
93MUSK0.62590779
94PTK60.61167340
95FGFR20.60817516
96ABL20.60395253
97ROCK10.59035669
98MAPK130.58946623
99STK380.57613292
100PIK3CA0.57592020
101MAP3K10.56738105
102NLK0.56314244
103NEK90.55249442
104PRKCA0.55112465
105MAP3K40.53985321
106DYRK1B0.52827792
107CSNK1G20.52776550
108DDR20.52618366
109MAP3K50.52110404
110ERBB40.51699626
111WNK10.51309405
112GRK10.50669488
113STK30.50484881
114PRKACA0.49687407
115TESK20.48523339
116UHMK10.48519609
117GSK3A0.46992038
118PRKCH0.46339650
119PRKACG0.45567267
120TEC0.44635445
121IGF1R0.43856510
122ERBB30.42945719
123ITK0.42659806
124NUAK10.41612815
125ABL10.41234308
126PRKG20.41174074
127IKBKE0.41084553
128PDPK10.40873968
129PRPF4B0.40618094
130ZAP700.40358579
131IKBKB0.40284856
132CSNK1A10.40154847
133PRKG10.40022961
134TNK20.39577529
135GRK70.39357946
136TSSK60.38494982
137ADRBK10.37043567
138MST1R0.36380316
139PRKCG0.35779475
140PRKD10.35590731
141CDK80.34708030
142CAMK2A0.33426347

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.05049601
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.90205044
3Sulfur metabolism_Homo sapiens_hsa009203.29926601
4Fatty acid elongation_Homo sapiens_hsa000622.71952263
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27646387
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.23422210
7Folate biosynthesis_Homo sapiens_hsa007902.03932712
8Butanoate metabolism_Homo sapiens_hsa006501.99812530
9Vibrio cholerae infection_Homo sapiens_hsa051101.90876603
10Fatty acid degradation_Homo sapiens_hsa000711.87470273
11Steroid biosynthesis_Homo sapiens_hsa001001.84257839
12Histidine metabolism_Homo sapiens_hsa003401.76984087
13Lysosome_Homo sapiens_hsa041421.76558701
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76093608
15Fatty acid metabolism_Homo sapiens_hsa012121.75727605
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72550706
17Peroxisome_Homo sapiens_hsa041461.71900143
18Propanoate metabolism_Homo sapiens_hsa006401.64036753
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62568120
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60346864
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.59709236
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57699446
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57693900
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55259102
25Tryptophan metabolism_Homo sapiens_hsa003801.54724361
26Type I diabetes mellitus_Homo sapiens_hsa049401.52922360
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52369685
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51376599
29Collecting duct acid secretion_Homo sapiens_hsa049661.50214273
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46955011
31Other glycan degradation_Homo sapiens_hsa005111.46648582
32Oxidative phosphorylation_Homo sapiens_hsa001901.46297551
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42164667
34Regulation of autophagy_Homo sapiens_hsa041401.38077534
35Nitrogen metabolism_Homo sapiens_hsa009101.34422810
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32642319
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28924263
38Sphingolipid metabolism_Homo sapiens_hsa006001.24327754
39Chemical carcinogenesis_Homo sapiens_hsa052041.21707806
40Vitamin digestion and absorption_Homo sapiens_hsa049771.15409166
41Pyruvate metabolism_Homo sapiens_hsa006201.14183629
42N-Glycan biosynthesis_Homo sapiens_hsa005101.12857729
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12263126
44beta-Alanine metabolism_Homo sapiens_hsa004101.11100172
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.08622410
46Glutathione metabolism_Homo sapiens_hsa004801.07970452
47Arginine and proline metabolism_Homo sapiens_hsa003301.05368270
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99859267
49Starch and sucrose metabolism_Homo sapiens_hsa005000.99573836
50Caffeine metabolism_Homo sapiens_hsa002320.99482085
51Vitamin B6 metabolism_Homo sapiens_hsa007500.97748767
52Phenylalanine metabolism_Homo sapiens_hsa003600.94388437
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.89988951
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.89522222
55Retinol metabolism_Homo sapiens_hsa008300.89506403
56Tyrosine metabolism_Homo sapiens_hsa003500.87682830
57Asthma_Homo sapiens_hsa053100.86326144
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86317539
59Ether lipid metabolism_Homo sapiens_hsa005650.86134956
60PPAR signaling pathway_Homo sapiens_hsa033200.84779256
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84365683
62Complement and coagulation cascades_Homo sapiens_hsa046100.83341466
63Parkinsons disease_Homo sapiens_hsa050120.82756736
64Renin secretion_Homo sapiens_hsa049240.82618650
65Staphylococcus aureus infection_Homo sapiens_hsa051500.82572062
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.79447303
67Fat digestion and absorption_Homo sapiens_hsa049750.78444341
68Insulin secretion_Homo sapiens_hsa049110.78121897
69Arachidonic acid metabolism_Homo sapiens_hsa005900.77749132
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75477083
71ABC transporters_Homo sapiens_hsa020100.73702731
72Metabolic pathways_Homo sapiens_hsa011000.73552663
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72701687
74Protein digestion and absorption_Homo sapiens_hsa049740.70701668
75Bile secretion_Homo sapiens_hsa049760.70370630
76Selenocompound metabolism_Homo sapiens_hsa004500.69729562
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69560792
78Linoleic acid metabolism_Homo sapiens_hsa005910.69192673
79Phototransduction_Homo sapiens_hsa047440.68341965
80Cardiac muscle contraction_Homo sapiens_hsa042600.68081557
81Alzheimers disease_Homo sapiens_hsa050100.66865154
82Rheumatoid arthritis_Homo sapiens_hsa053230.65971081
83Carbon metabolism_Homo sapiens_hsa012000.64560590
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62863418
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61303889
86Galactose metabolism_Homo sapiens_hsa000520.60453213
87Autoimmune thyroid disease_Homo sapiens_hsa053200.58970406
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.58717153
89Pancreatic secretion_Homo sapiens_hsa049720.58643218
90Mineral absorption_Homo sapiens_hsa049780.57839207
91Proteasome_Homo sapiens_hsa030500.57427894
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57212440
93Fructose and mannose metabolism_Homo sapiens_hsa000510.55575905
94Huntingtons disease_Homo sapiens_hsa050160.54780013
95Phagosome_Homo sapiens_hsa041450.52605514
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51992379
97Salivary secretion_Homo sapiens_hsa049700.50754662
98Allograft rejection_Homo sapiens_hsa053300.50695463
99Ovarian steroidogenesis_Homo sapiens_hsa049130.50614740
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50155559
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.50149253
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50057823
103Graft-versus-host disease_Homo sapiens_hsa053320.49903264
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48397679
105Thyroid hormone synthesis_Homo sapiens_hsa049180.46210980
106Arginine biosynthesis_Homo sapiens_hsa002200.46077753
107Glycerolipid metabolism_Homo sapiens_hsa005610.45896266
108Renin-angiotensin system_Homo sapiens_hsa046140.45720359
109Pentose phosphate pathway_Homo sapiens_hsa000300.43083427
110Synaptic vesicle cycle_Homo sapiens_hsa047210.41237091
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38916080
112Circadian rhythm_Homo sapiens_hsa047100.38709719
113Sulfur relay system_Homo sapiens_hsa041220.38623709
114Prion diseases_Homo sapiens_hsa050200.37325914
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37076907
116Amphetamine addiction_Homo sapiens_hsa050310.36127883
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34883978

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