TMEM59L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.13582859
2synaptic vesicle exocytosis (GO:0016079)5.66826987
3vocalization behavior (GO:0071625)5.47630663
4synaptic vesicle maturation (GO:0016188)5.43054825
5glutamate secretion (GO:0014047)5.42311358
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.30205444
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28424383
8locomotory exploration behavior (GO:0035641)5.24719308
9regulation of synaptic vesicle exocytosis (GO:2000300)5.18131797
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.09293349
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04341707
12neuronal action potential propagation (GO:0019227)5.03689236
13regulation of glutamate receptor signaling pathway (GO:1900449)5.01064318
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.88940776
15protein localization to synapse (GO:0035418)4.82028081
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.80592093
17neurotransmitter secretion (GO:0007269)4.75046546
18neuron cell-cell adhesion (GO:0007158)4.73198252
19regulation of synaptic vesicle transport (GO:1902803)4.63499260
20synaptic transmission, glutamatergic (GO:0035249)4.40174729
21glutamate receptor signaling pathway (GO:0007215)4.40135317
22neurotransmitter-gated ion channel clustering (GO:0072578)4.38508362
23neuron-neuron synaptic transmission (GO:0007270)4.32335591
24exploration behavior (GO:0035640)4.19560174
25L-amino acid import (GO:0043092)4.17861092
26gamma-aminobutyric acid signaling pathway (GO:0007214)4.14835912
27neuronal ion channel clustering (GO:0045161)4.14404845
28regulation of neuronal synaptic plasticity (GO:0048168)4.05528945
29positive regulation of dendritic spine development (GO:0060999)4.05124582
30negative regulation of synaptic transmission, GABAergic (GO:0032229)4.00655665
31regulation of voltage-gated calcium channel activity (GO:1901385)3.99632690
32positive regulation of synapse maturation (GO:0090129)3.96567389
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93046943
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89013461
35amino acid import (GO:0043090)3.88686396
36neuromuscular process controlling posture (GO:0050884)3.86387549
37neurotransmitter transport (GO:0006836)3.85634948
38potassium ion homeostasis (GO:0055075)3.83108297
39gamma-aminobutyric acid transport (GO:0015812)3.79948392
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79417784
41long-term memory (GO:0007616)3.78079598
42positive regulation of dendritic spine morphogenesis (GO:0061003)3.77042591
43long-term synaptic potentiation (GO:0060291)3.71985212
44axon ensheathment in central nervous system (GO:0032291)3.71573755
45central nervous system myelination (GO:0022010)3.71573755
46establishment of mitochondrion localization (GO:0051654)3.70839250
47auditory behavior (GO:0031223)3.69901500
48cerebellar Purkinje cell differentiation (GO:0021702)3.67534094
49positive regulation of membrane potential (GO:0045838)3.66842510
50cellular potassium ion homeostasis (GO:0030007)3.66801609
51presynaptic membrane assembly (GO:0097105)3.65733045
52regulation of postsynaptic membrane potential (GO:0060078)3.63727723
53postsynaptic membrane organization (GO:0001941)3.62614045
54proline transport (GO:0015824)3.60118066
55cerebellar granule cell differentiation (GO:0021707)3.59687153
56regulation of neurotransmitter levels (GO:0001505)3.58623499
57potassium ion import (GO:0010107)3.52936835
58activation of protein kinase A activity (GO:0034199)3.52437323
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.52318551
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.50850090
61response to histamine (GO:0034776)3.50205886
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.50146669
63presynaptic membrane organization (GO:0097090)3.49320832
64regulation of synaptic plasticity (GO:0048167)3.47959181
65synaptic vesicle endocytosis (GO:0048488)3.47319678
66regulation of neurotransmitter secretion (GO:0046928)3.46932845
67regulation of vesicle fusion (GO:0031338)3.46887107
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45273247
69neuron recognition (GO:0008038)3.43908830
70cell communication by electrical coupling (GO:0010644)3.43665839
71dendritic spine organization (GO:0097061)3.43221020
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42821703
73regulation of synapse structural plasticity (GO:0051823)3.37791681
74regulation of dendritic spine development (GO:0060998)3.37439846
75cellular sodium ion homeostasis (GO:0006883)3.37321226
76acidic amino acid transport (GO:0015800)3.32859470
77neuromuscular synaptic transmission (GO:0007274)3.32290996
78transmission of nerve impulse (GO:0019226)3.31706577
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27805030
80cell migration in hindbrain (GO:0021535)3.27204138
81membrane depolarization during action potential (GO:0086010)3.25524606
82regulation of neurotransmitter transport (GO:0051588)3.25410622
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23785577
84regulation of glutamate secretion (GO:0014048)3.23132013
85regulation of ARF protein signal transduction (GO:0032012)3.22894137
86membrane depolarization (GO:0051899)3.21457775
87regulation of synapse maturation (GO:0090128)3.21389671
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20111170
89synaptic transmission (GO:0007268)3.18901491
90ATP hydrolysis coupled proton transport (GO:0015991)3.18774579
91energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.18774579
92layer formation in cerebral cortex (GO:0021819)3.18504474
93establishment of synaptic vesicle localization (GO:0097480)3.17857169
94synaptic vesicle transport (GO:0048489)3.17857169
95behavioral fear response (GO:0001662)3.17659931
96behavioral defense response (GO:0002209)3.17659931
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15465964
98positive regulation of neurotransmitter transport (GO:0051590)3.14442623
99response to auditory stimulus (GO:0010996)3.14434498
100positive regulation of synaptic transmission (GO:0050806)3.14210692
101cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12281827
102fear response (GO:0042596)3.09684956
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09217520
104regulation of synaptic transmission (GO:0050804)3.08888319
105cerebellar Purkinje cell layer development (GO:0021680)3.08876383
106transferrin transport (GO:0033572)3.07262849
107response to pheromone (GO:0019236)3.06548015
108startle response (GO:0001964)3.05825516
109sodium ion export (GO:0071436)3.05651599
110neurotransmitter uptake (GO:0001504)3.04564419
111positive regulation of synapse assembly (GO:0051965)3.03609267
112establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.03505379
113membrane hyperpolarization (GO:0060081)3.02883849
114learning (GO:0007612)3.01801705
115negative regulation of amino acid transport (GO:0051956)3.01650809
116positive regulation of neurotransmitter secretion (GO:0001956)3.01605876
117axonal fasciculation (GO:0007413)2.99777047
118synapse assembly (GO:0007416)2.98496643
119regulation of synaptic transmission, GABAergic (GO:0032228)2.97917167
120behavioral response to cocaine (GO:0048148)2.97620367
121negative regulation of dendrite morphogenesis (GO:0050774)2.96951047
122innervation (GO:0060384)2.95548006
123dendritic spine morphogenesis (GO:0060997)2.94585845
124detection of calcium ion (GO:0005513)2.94043324
125neuromuscular process controlling balance (GO:0050885)2.91162615
126calcium ion-dependent exocytosis (GO:0017156)2.90444647
127regulation of dendritic spine morphogenesis (GO:0061001)2.90200494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.10094471
2GBX2_23144817_ChIP-Seq_PC3_Human4.03332974
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24802545
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13470128
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00992791
6REST_21632747_ChIP-Seq_MESCs_Mouse2.92439602
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68688080
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66830089
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66830089
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64314924
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59901242
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54624123
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53944542
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.50817908
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50693457
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.48361611
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.46426354
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.37651438
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32816460
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.28101629
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27211780
22DROSHA_22980978_ChIP-Seq_HELA_Human2.25607373
23TAF15_26573619_Chip-Seq_HEK293_Human2.24348075
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23721082
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19983411
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.19407613
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.10586013
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10501889
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05650365
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89807525
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86688789
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86326654
33SMAD4_21799915_ChIP-Seq_A2780_Human1.80599870
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70662073
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70160062
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69253850
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63002604
38P300_19829295_ChIP-Seq_ESCs_Human1.57095372
39AR_21572438_ChIP-Seq_LNCaP_Human1.56661866
40* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54692656
41ZNF274_21170338_ChIP-Seq_K562_Hela1.49214151
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48445678
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48142510
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.47507939
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44017515
46* KDM2B_26808549_Chip-Seq_K562_Human1.39515626
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38052940
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36236543
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34834070
50AR_25329375_ChIP-Seq_VCAP_Human1.34747551
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34482688
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.33772862
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.30981252
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.30676902
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30335843
56TET1_21490601_ChIP-Seq_MESCs_Mouse1.29184692
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28541185
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26167437
59RNF2_27304074_Chip-Seq_NSC_Mouse1.25917681
60IGF1R_20145208_ChIP-Seq_DFB_Human1.24479516
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.24234530
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23437118
63* CTCF_27219007_Chip-Seq_Bcells_Human1.23039382
64STAT3_23295773_ChIP-Seq_U87_Human1.22151478
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21666630
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21168208
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20000870
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17782450
69* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17261659
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.15450625
71AR_19668381_ChIP-Seq_PC3_Human1.14645226
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13916028
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.13733537
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12938286
75FUS_26573619_Chip-Seq_HEK293_Human1.12410442
76TCF4_23295773_ChIP-Seq_U87_Human1.12331306
77VDR_22108803_ChIP-Seq_LS180_Human1.11358381
78* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11231615
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09988882
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08224415
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06866129
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04156262
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03242083
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02115675
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.00719908
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.00573617
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00096297
88* RUNX2_22187159_ChIP-Seq_PCA_Human0.99717559
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98782485
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97877775
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.96680070
92JUN_21703547_ChIP-Seq_K562_Human0.96095147
93YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94955290
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94907233
95ER_23166858_ChIP-Seq_MCF-7_Human0.94742970
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94141550
97OCT4_19829295_ChIP-Seq_ESCs_Human0.93615848
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93576249
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91830319
100AHR_22903824_ChIP-Seq_MCF-7_Human0.91650270
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90716759
102* TP53_20018659_ChIP-ChIP_R1E_Mouse0.90461784
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88497653
104NANOG_18555785_Chip-Seq_ESCs_Mouse0.88276870
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88115963
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87821244
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87328647
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86829522
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86746659
110* RING1B_27294783_Chip-Seq_NPCs_Mouse0.86678287
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84068853
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84068853
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.83564701
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82896745
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82265690
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82160239
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81598459
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81291188
119DPY_21335234_ChIP-Seq_ESCs_Mouse0.81277854
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80642921
121KDM2B_26808549_Chip-Seq_REH_Human0.80356515
122SOX9_26525672_Chip-Seq_HEART_Mouse0.79354477
123KLF4_19829295_ChIP-Seq_ESCs_Human0.79253972
124SMC4_20622854_ChIP-Seq_HELA_Human0.78970428
125LXR_22292898_ChIP-Seq_THP-1_Human0.78658017
126* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75050349
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74159324
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.73519933
129SMAD4_21741376_ChIP-Seq_ESCs_Human0.72970201
130NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.69418449
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69196786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.89066774
2MP0003880_abnormal_central_pattern5.16732954
3MP0003635_abnormal_synaptic_transmissio4.07104283
4MP0009745_abnormal_behavioral_response3.51511128
5MP0009046_muscle_twitch3.47886001
6MP0004270_analgesia3.32260417
7MP0002064_seizures3.31820131
8MP0001968_abnormal_touch/_nociception3.27205634
9MP0002063_abnormal_learning/memory/cond3.21849612
10MP0002572_abnormal_emotion/affect_behav2.88327315
11MP0002272_abnormal_nervous_system2.77373230
12MP0002736_abnormal_nociception_after2.76755706
13MP0002735_abnormal_chemical_nociception2.63112641
14MP0002734_abnormal_mechanical_nocicepti2.61680961
15MP0005423_abnormal_somatic_nervous2.61438975
16MP0001501_abnormal_sleep_pattern2.47923873
17MP0002822_catalepsy2.41800921
18MP0001440_abnormal_grooming_behavior2.40460961
19MP0001486_abnormal_startle_reflex2.38041432
20MP0002067_abnormal_sensory_capabilities2.15660577
21MP0006276_abnormal_autonomic_nervous2.12491105
22MP0003122_maternal_imprinting2.12070812
23MP0002733_abnormal_thermal_nociception2.03957413
24MP0001970_abnormal_pain_threshold2.02383214
25MP0003787_abnormal_imprinting1.88389834
26MP0008569_lethality_at_weaning1.84004904
27MP0002184_abnormal_innervation1.80925401
28MP0009780_abnormal_chondrocyte_physiolo1.78225666
29MP0005646_abnormal_pituitary_gland1.74789589
30MP0002557_abnormal_social/conspecific_i1.73697797
31MP0005645_abnormal_hypothalamus_physiol1.71161986
32MP0004924_abnormal_behavior1.70981260
33MP0005386_behavior/neurological_phenoty1.70981260
34MP0003879_abnormal_hair_cell1.67525770
35MP0004142_abnormal_muscle_tone1.65343166
36MP0001984_abnormal_olfaction1.62398736
37MP0002909_abnormal_adrenal_gland1.61992724
38MP0003329_amyloid_beta_deposits1.58714212
39MP0004811_abnormal_neuron_physiology1.57468302
40MP0001529_abnormal_vocalization1.55326430
41MP0004858_abnormal_nervous_system1.53917707
42MP0001502_abnormal_circadian_rhythm1.47444546
43MP0000778_abnormal_nervous_system1.46935712
44MP0001905_abnormal_dopamine_level1.46564201
45MP0000955_abnormal_spinal_cord1.41554966
46MP0002066_abnormal_motor_capabilities/c1.40118923
47MP0002882_abnormal_neuron_morphology1.33418325
48MP0001188_hyperpigmentation1.30865359
49MP0003633_abnormal_nervous_system1.22980554
50MP0000013_abnormal_adipose_tissue1.20611679
51MP0002837_dystrophic_cardiac_calcinosis1.17592702
52MP0004885_abnormal_endolymph1.14198177
53MP0000751_myopathy1.10117729
54MP0002876_abnormal_thyroid_physiology1.07805084
55MP0003631_nervous_system_phenotype1.06161859
56MP0008872_abnormal_physiological_respon1.05323453
57MP0003183_abnormal_peptide_metabolism1.05259569
58MP0004145_abnormal_muscle_electrophysio1.04576667
59MP0010386_abnormal_urinary_bladder1.04049591
60MP0005551_abnormal_eye_electrophysiolog1.02966715
61MP0002229_neurodegeneration0.99517970
62MP0002069_abnormal_eating/drinking_beha0.96775943
63MP0002152_abnormal_brain_morphology0.96485885
64MP0003123_paternal_imprinting0.96237844
65MP0004742_abnormal_vestibular_system0.93704773
66MP0008877_abnormal_DNA_methylation0.91003747
67MP0005535_abnormal_body_temperature0.87882727
68MP0003121_genomic_imprinting0.86225269
69MP0001963_abnormal_hearing_physiology0.85977671
70MP0004147_increased_porphyrin_level0.81162925
71MP0001986_abnormal_taste_sensitivity0.80739073
72MP0008874_decreased_physiological_sensi0.79650134
73MP0004085_abnormal_heartbeat0.79087696
74MP0004215_abnormal_myocardial_fiber0.74463189
75MP0003632_abnormal_nervous_system0.74374386
76MP0002752_abnormal_somatic_nervous0.73007541
77MP0001664_abnormal_digestion0.72076361
78MP0000631_abnormal_neuroendocrine_gland0.71528241
79MP0005167_abnormal_blood-brain_barrier0.70364580
80MP0005499_abnormal_olfactory_system0.70144522
81MP0005394_taste/olfaction_phenotype0.70144522
82MP0003634_abnormal_glial_cell0.69697598
83MP0004043_abnormal_pH_regulation0.68248202
84MP0001177_atelectasis0.66652373
85MP0000026_abnormal_inner_ear0.65710907
86MP0000604_amyloidosis0.64401697
87MP0004484_altered_response_of0.63671232
88MP0001348_abnormal_lacrimal_gland0.63001701
89MP0006072_abnormal_retinal_apoptosis0.62872290
90MP0003861_abnormal_nervous_system0.62457230
91MP0008961_abnormal_basal_metabolism0.62256632
92MP0002653_abnormal_ependyma_morphology0.62042450
93MP0002638_abnormal_pupillary_reflex0.62011184
94MP0004233_abnormal_muscle_weight0.61313663
95MP0001346_abnormal_lacrimal_gland0.61288039
96MP0003137_abnormal_impulse_conducting0.58409094
97MP0002090_abnormal_vision0.56372622
98MP0003690_abnormal_glial_cell0.55950378
99MP0001485_abnormal_pinna_reflex0.55926199
100MP0001943_abnormal_respiration0.55373165
101MP0010768_mortality/aging0.54682528
102MP0003075_altered_response_to0.54329136
103MP0004130_abnormal_muscle_cell0.53905873
104MP0003283_abnormal_digestive_organ0.52157605
105MP0003938_abnormal_ear_development0.51973918
106MP0001299_abnormal_eye_distance/0.51048246
107MP0000566_synostosis0.50920942
108MP0005623_abnormal_meninges_morphology0.50065207
109MP0003956_abnormal_body_size0.49753141
110MP0000579_abnormal_nail_morphology0.49381768
111MP0000920_abnormal_myelination0.49261473
112MP0010770_preweaning_lethality0.48961916
113MP0002082_postnatal_lethality0.48961916
114MP0010769_abnormal_survival0.48791871
115MP0004133_heterotaxia0.45734259

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.30116425
2Myokymia (HP:0002411)6.44775618
3Atonic seizures (HP:0010819)5.93524852
4Focal seizures (HP:0007359)5.75568073
5Epileptic encephalopathy (HP:0200134)5.46130600
6Febrile seizures (HP:0002373)5.36367449
7Visual hallucinations (HP:0002367)5.09193324
8Absence seizures (HP:0002121)4.80635262
9Progressive cerebellar ataxia (HP:0002073)4.61120981
10Dialeptic seizures (HP:0011146)4.35043873
11Generalized tonic-clonic seizures (HP:0002069)4.09422083
12Neurofibrillary tangles (HP:0002185)3.82355043
13Hyperventilation (HP:0002883)3.69665397
14Action tremor (HP:0002345)3.57321365
15Gaze-evoked nystagmus (HP:0000640)3.50462367
16Broad-based gait (HP:0002136)3.41062998
17Abnormal eating behavior (HP:0100738)3.37359185
18Cerebral hypomyelination (HP:0006808)3.21640565
19Papilledema (HP:0001085)3.18214614
20Dysdiadochokinesis (HP:0002075)3.15536593
21Impaired vibration sensation in the lower limbs (HP:0002166)3.09369001
22Truncal ataxia (HP:0002078)3.08868445
23Akinesia (HP:0002304)3.07498053
24Depression (HP:0000716)3.06939592
25Cerebral inclusion bodies (HP:0100314)3.00359087
26Anxiety (HP:0000739)2.97111998
27Supranuclear gaze palsy (HP:0000605)2.95951083
28Abnormality of the lower motor neuron (HP:0002366)2.94136983
29Dysmetria (HP:0001310)2.93315527
30Amblyopia (HP:0000646)2.92155560
31Pheochromocytoma (HP:0002666)2.91210750
32Poor eye contact (HP:0000817)2.87327675
33Polyphagia (HP:0002591)2.86971361
34Tetraplegia (HP:0002445)2.82014732
35Ankle clonus (HP:0011448)2.81708292
36Abnormal hair whorl (HP:0010721)2.81312755
37Neuronal loss in central nervous system (HP:0002529)2.75870386
38Failure to thrive in infancy (HP:0001531)2.73104864
39Epileptiform EEG discharges (HP:0011182)2.69061913
40Obstructive sleep apnea (HP:0002870)2.67624402
41Neuroendocrine neoplasm (HP:0100634)2.64478559
42Progressive inability to walk (HP:0002505)2.64119146
43Abnormal social behavior (HP:0012433)2.63427713
44Impaired social interactions (HP:0000735)2.63427713
45Impaired smooth pursuit (HP:0007772)2.59917079
46Apathy (HP:0000741)2.59246342
47Postural instability (HP:0002172)2.58704415
48Scanning speech (HP:0002168)2.57843289
49Peripheral hypomyelination (HP:0007182)2.57815233
50Urinary bladder sphincter dysfunction (HP:0002839)2.55717878
51Clonus (HP:0002169)2.52596694
52Dysmetric saccades (HP:0000641)2.50658672
53Excessive salivation (HP:0003781)2.48285868
54Drooling (HP:0002307)2.48285868
55EEG with generalized epileptiform discharges (HP:0011198)2.47212708
56Hemiparesis (HP:0001269)2.46453080
57Diplopia (HP:0000651)2.46212618
58Abnormality of binocular vision (HP:0011514)2.46212618
59Bradykinesia (HP:0002067)2.45855074
60Genetic anticipation (HP:0003743)2.45735225
61Status epilepticus (HP:0002133)2.41395369
62Gait imbalance (HP:0002141)2.41034908
63Limb dystonia (HP:0002451)2.40582024
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39417540
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.39417540
66Diminished motivation (HP:0000745)2.38246677
67Mutism (HP:0002300)2.36749558
68Amyotrophic lateral sclerosis (HP:0007354)2.36428302
69Morphological abnormality of the pyramidal tract (HP:0002062)2.34655644
70Abnormality of ocular smooth pursuit (HP:0000617)2.31895431
71Hypsarrhythmia (HP:0002521)2.29862261
72Insomnia (HP:0100785)2.29178098
73CNS hypomyelination (HP:0003429)2.28732313
74Poor suck (HP:0002033)2.27343264
75Spastic gait (HP:0002064)2.26523234
76Hemiplegia (HP:0002301)2.26443625
77Hypoventilation (HP:0002791)2.25581368
78Spastic tetraparesis (HP:0001285)2.23761261
79Fetal akinesia sequence (HP:0001989)2.23671284
80Urinary urgency (HP:0000012)2.18486139
81Oligomenorrhea (HP:0000876)2.17800186
82Inability to walk (HP:0002540)2.17423249
83Ventricular fibrillation (HP:0001663)2.15995120
84Congenital primary aphakia (HP:0007707)2.15727473
85Spastic tetraplegia (HP:0002510)2.13496697
86Split foot (HP:0001839)2.13484623
87Specific learning disability (HP:0001328)2.12674697
88Impaired vibratory sensation (HP:0002495)2.09818134
89Psychosis (HP:0000709)2.09731279
90Focal dystonia (HP:0004373)2.09286290
91Rigidity (HP:0002063)2.07293306
92Agitation (HP:0000713)2.07018876
93Torticollis (HP:0000473)2.06744368
94Medial flaring of the eyebrow (HP:0010747)2.06506846
95Narrow nasal bridge (HP:0000446)2.06377771
96Absent speech (HP:0001344)2.06292253
97Abnormality of the labia minora (HP:0012880)2.00626752
98Gait ataxia (HP:0002066)1.98923992
99Nephrogenic diabetes insipidus (HP:0009806)1.98816968
100Megalencephaly (HP:0001355)1.98563961
101Choreoathetosis (HP:0001266)1.98421120
102Generalized myoclonic seizures (HP:0002123)1.97945373
103Esotropia (HP:0000565)1.97924028
104Rapidly progressive (HP:0003678)1.96202872
105Incomplete penetrance (HP:0003829)1.96131047
106Protruding tongue (HP:0010808)1.96085166
107Stereotypic behavior (HP:0000733)1.95636192
108Intention tremor (HP:0002080)1.95576795
109Blue irides (HP:0000635)1.93467459
110Delusions (HP:0000746)1.93371924
111Resting tremor (HP:0002322)1.92188413
112Abnormal mitochondria in muscle tissue (HP:0008316)1.91698558
113Sleep apnea (HP:0010535)1.91615236
114Insidious onset (HP:0003587)1.90152433
115Termporal pattern (HP:0011008)1.90152433
116Acute necrotizing encephalopathy (HP:0006965)1.89985231
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89886491
118Hand muscle atrophy (HP:0009130)1.88353181
119Abnormality of the corticospinal tract (HP:0002492)1.87346722
120Hypoplasia of the corpus callosum (HP:0002079)1.86197020
121Annular pancreas (HP:0001734)1.82420596
122Lower limb muscle weakness (HP:0007340)1.82135015
123Abnormality of saccadic eye movements (HP:0000570)1.80772047
124Craniofacial dystonia (HP:0012179)1.79812610
125Postural tremor (HP:0002174)1.78642924
126Abnormality of pain sensation (HP:0010832)1.77895329
127Impaired pain sensation (HP:0007328)1.77895329
128Spinal canal stenosis (HP:0003416)1.72006162
129Paraplegia (HP:0010550)1.71808676
130Pointed chin (HP:0000307)1.67501570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.69716719
2CASK3.72101070
3EPHA43.63125509
4MAP3K93.55093689
5MAP3K123.14557649
6MAP3K43.12291099
7MAP2K72.81398709
8MINK12.51619047
9DAPK22.44018496
10ARAF2.21293442
11CDK192.16888436
12MAP2K42.09589783
13MARK11.96657962
14NTRK21.90504348
15PLK21.88363303
16DAPK11.88115150
17PAK61.81238853
18KSR21.78017351
19GRK51.66794768
20PRPF4B1.64887548
21RIPK41.49530683
22CAMKK11.45217429
23CAMKK21.40244238
24PRKD31.39236461
25CDK51.39080056
26KSR11.37715745
27PNCK1.37135490
28PRKCG1.36758201
29AKT31.33980996
30NTRK11.28415106
31MAP3K131.24542261
32TNIK1.23911294
33MAPK131.21020058
34OXSR11.17268427
35STK381.11919977
36CAMK2A1.09765722
37UHMK11.09137589
38SGK4941.08686399
39SGK2231.08686399
40FES1.06034244
41CAMK2B1.01629049
42BRAF1.01586341
43CCNB11.01548117
44SGK20.98667794
45NME10.97042587
46RIPK10.93905927
47CDK180.91838840
48PKN10.91399532
49SIK30.90633977
50SIK20.89826026
51MAP3K20.89173861
52PTK2B0.89137731
53CAMK10.88549820
54CDK150.87175585
55CDK140.85814169
56DYRK20.81502167
57LIMK10.81288695
58TNK20.78609243
59MAPK120.77231624
60PRKCH0.76670804
61CDK11A0.75865817
62PINK10.75271796
63RAF10.74261291
64PHKG10.74033413
65PHKG20.74033413
66ALK0.73824237
67TSSK60.73823381
68SGK30.70936615
69BMPR20.68831129
70STK110.67185592
71BRSK10.66611049
72CAMK2G0.66292728
73CAMK2D0.66158156
74PRKCE0.63277178
75WNK30.63052363
76MAP3K10.62220701
77LMTK20.61658804
78SGK10.61435103
79PRKCZ0.60404454
80MAP3K110.59936647
81TESK10.59664862
82WNK10.57772807
83PAK30.57419705
84FER0.57339580
85PDK10.57232890
86GRK70.57098056
87TYRO30.56905890
88DYRK1A0.56359577
89PDK40.54894144
90PDK30.54894144
91PDPK10.54671734
92CSNK1G30.51221599
93RET0.50799102
94LATS20.49895196
95DAPK30.49467414
96CSNK1G20.47394348
97CSNK1A1L0.45158389
98TAOK20.44578132
99MUSK0.43839925
100TAOK10.43640554
101NEK10.43293572
102ADRBK20.43158707
103RPS6KA30.42914227
104MARK20.41802318
105MAP2K10.40563148
106ADRBK10.39271831
107FYN0.39201585
108CAMK40.38799369
109BCR0.38228158
110FGFR20.36519972
111PRKCA0.36405971
112ROCK20.36400353
113NEK60.36191978
114WNK40.35111505
115PRKACA0.35027803
116CDC42BPA0.34865783
117MAPK100.34005491
118CSNK1E0.30363482
119PRKG10.29467916
120CSNK1A10.29444133
121ERBB20.27900541
122CSNK1G10.27633083
123MAPKAPK50.27524900
124MAPK80.27344481
125CAMK1G0.27160098
126CSNK1D0.26757698

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.30691286
2Synaptic vesicle cycle_Homo sapiens_hsa047214.00253619
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87445943
4GABAergic synapse_Homo sapiens_hsa047272.83913622
5Circadian entrainment_Homo sapiens_hsa047132.67646259
6Collecting duct acid secretion_Homo sapiens_hsa049662.65568311
7Long-term potentiation_Homo sapiens_hsa047202.65439709
8Olfactory transduction_Homo sapiens_hsa047402.59621317
9Morphine addiction_Homo sapiens_hsa050322.56727433
10Amphetamine addiction_Homo sapiens_hsa050312.50311000
11Glutamatergic synapse_Homo sapiens_hsa047242.49157080
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16472179
13Dopaminergic synapse_Homo sapiens_hsa047282.11651101
14Insulin secretion_Homo sapiens_hsa049112.10094829
15Salivary secretion_Homo sapiens_hsa049702.08873904
16Taste transduction_Homo sapiens_hsa047422.07374661
17Long-term depression_Homo sapiens_hsa047301.80390202
18Gastric acid secretion_Homo sapiens_hsa049711.74712884
19Cholinergic synapse_Homo sapiens_hsa047251.72295938
20Vibrio cholerae infection_Homo sapiens_hsa051101.70391948
21Serotonergic synapse_Homo sapiens_hsa047261.69816871
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66650483
23Cocaine addiction_Homo sapiens_hsa050301.60218732
24Calcium signaling pathway_Homo sapiens_hsa040201.59519812
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58833547
26Renin secretion_Homo sapiens_hsa049241.58246474
27Oxytocin signaling pathway_Homo sapiens_hsa049211.51215701
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48053268
29Oxidative phosphorylation_Homo sapiens_hsa001901.40053721
30Vitamin B6 metabolism_Homo sapiens_hsa007501.39737646
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31882998
32Cardiac muscle contraction_Homo sapiens_hsa042601.26998017
33GnRH signaling pathway_Homo sapiens_hsa049121.25199965
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24874109
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22120779
36Gap junction_Homo sapiens_hsa045401.18495372
37cAMP signaling pathway_Homo sapiens_hsa040241.16314995
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13480857
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12964548
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04484276
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04046534
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03731593
43Alzheimers disease_Homo sapiens_hsa050101.01754141
44Estrogen signaling pathway_Homo sapiens_hsa049150.99500118
45Type II diabetes mellitus_Homo sapiens_hsa049300.98079586
46Parkinsons disease_Homo sapiens_hsa050120.95219707
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90922291
48Phototransduction_Homo sapiens_hsa047440.90359691
49Melanogenesis_Homo sapiens_hsa049160.86881483
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.85991110
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82087850
52ErbB signaling pathway_Homo sapiens_hsa040120.80576074
53Glioma_Homo sapiens_hsa052140.80222899
54Axon guidance_Homo sapiens_hsa043600.79979625
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79115445
56Pancreatic secretion_Homo sapiens_hsa049720.78559660
57Oocyte meiosis_Homo sapiens_hsa041140.75471801
58Thyroid hormone synthesis_Homo sapiens_hsa049180.74929042
59Type I diabetes mellitus_Homo sapiens_hsa049400.74321566
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71878137
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70942705
62Huntingtons disease_Homo sapiens_hsa050160.67139872
63Rheumatoid arthritis_Homo sapiens_hsa053230.65109231
64Dilated cardiomyopathy_Homo sapiens_hsa054140.61557830
65MAPK signaling pathway_Homo sapiens_hsa040100.59526135
66Glucagon signaling pathway_Homo sapiens_hsa049220.59315501
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.57109561
68Dorso-ventral axis formation_Homo sapiens_hsa043200.57091512
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53804530
70Circadian rhythm_Homo sapiens_hsa047100.52712300
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51408295
72Arginine and proline metabolism_Homo sapiens_hsa003300.50244575
73Inositol phosphate metabolism_Homo sapiens_hsa005620.48103169
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47924951
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45594671
76Alcoholism_Homo sapiens_hsa050340.44773056
77Choline metabolism in cancer_Homo sapiens_hsa052310.44696855
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42136863
79Ras signaling pathway_Homo sapiens_hsa040140.41644669
80Arginine biosynthesis_Homo sapiens_hsa002200.40945229
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39043038
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.38934167
83Phagosome_Homo sapiens_hsa041450.38720192
84Prion diseases_Homo sapiens_hsa050200.37677569
85Fatty acid biosynthesis_Homo sapiens_hsa000610.35272908
86Bile secretion_Homo sapiens_hsa049760.34525173
87AMPK signaling pathway_Homo sapiens_hsa041520.31891423
88Rap1 signaling pathway_Homo sapiens_hsa040150.30597768
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30364556
90Endocytosis_Homo sapiens_hsa041440.29973762
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29001835
92Insulin signaling pathway_Homo sapiens_hsa049100.28944774
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28289536
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27823645
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27064101
96Hippo signaling pathway_Homo sapiens_hsa043900.26870590
97VEGF signaling pathway_Homo sapiens_hsa043700.26733591
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26712281
99Ovarian steroidogenesis_Homo sapiens_hsa049130.25994182
100Histidine metabolism_Homo sapiens_hsa003400.25883719
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.24115138
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22690370
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22208548
104beta-Alanine metabolism_Homo sapiens_hsa004100.21902445
105African trypanosomiasis_Homo sapiens_hsa051430.21842139
106Wnt signaling pathway_Homo sapiens_hsa043100.21778350
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.21548218
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21502032
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21051162
110Regulation of autophagy_Homo sapiens_hsa041400.19503962
111Mineral absorption_Homo sapiens_hsa049780.19152139
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18648513

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