TMEM60

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)7.06684982
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.51707475
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.29642209
4ATP synthesis coupled proton transport (GO:0015986)6.13781138
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.13781138
6protein neddylation (GO:0045116)5.58507903
7respiratory electron transport chain (GO:0022904)5.32446596
8central nervous system myelination (GO:0022010)5.29598658
9axon ensheathment in central nervous system (GO:0032291)5.29598658
10electron transport chain (GO:0022900)5.18652178
11fatty acid elongation (GO:0030497)4.57418718
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.55553579
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.55553579
14NADH dehydrogenase complex assembly (GO:0010257)4.55553579
15proteasome assembly (GO:0043248)4.43212835
16protein complex biogenesis (GO:0070271)4.37768502
17long-chain fatty acid biosynthetic process (GO:0042759)4.16764689
18CENP-A containing nucleosome assembly (GO:0034080)4.01515429
19DNA double-strand break processing (GO:0000729)3.93176801
20mitochondrial respiratory chain complex assembly (GO:0033108)3.92719902
21chromatin remodeling at centromere (GO:0031055)3.91270220
22exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.88626134
23respiratory chain complex IV assembly (GO:0008535)3.85580737
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.76027859
25presynaptic membrane assembly (GO:0097105)3.71468919
26dopamine transport (GO:0015872)3.68154533
27preassembly of GPI anchor in ER membrane (GO:0016254)3.67308458
28water-soluble vitamin biosynthetic process (GO:0042364)3.62787595
29hydrogen ion transmembrane transport (GO:1902600)3.59244729
30GPI anchor biosynthetic process (GO:0006506)3.57361135
31protein K6-linked ubiquitination (GO:0085020)3.55950033
32maturation of 5.8S rRNA (GO:0000460)3.49789294
33kinetochore assembly (GO:0051382)3.48819074
34presynaptic membrane organization (GO:0097090)3.47429572
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.47394461
36termination of RNA polymerase III transcription (GO:0006386)3.47394461
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.45678700
38protein targeting to mitochondrion (GO:0006626)3.44644155
397-methylguanosine mRNA capping (GO:0006370)3.42545492
40synapsis (GO:0007129)3.42240329
41GTP biosynthetic process (GO:0006183)3.40855673
427-methylguanosine RNA capping (GO:0009452)3.38821369
43RNA capping (GO:0036260)3.38821369
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37683700
45regulation of dopamine metabolic process (GO:0042053)3.36224407
46regulation of catecholamine metabolic process (GO:0042069)3.36224407
47dopamine biosynthetic process (GO:0042416)3.35435920
48histone exchange (GO:0043486)3.34657175
49kinetochore organization (GO:0051383)3.29964096
50substantia nigra development (GO:0021762)3.29526320
51proton transport (GO:0015992)3.28915390
52signal peptide processing (GO:0006465)3.25798779
53protein deneddylation (GO:0000338)3.25376959
54neuron cell-cell adhesion (GO:0007158)3.24085887
55platelet dense granule organization (GO:0060155)3.23750383
56negative regulation of neurotransmitter transport (GO:0051589)3.22522775
57establishment of protein localization to mitochondrion (GO:0072655)3.21339150
58hydrogen transport (GO:0006818)3.20561066
59cytochrome complex assembly (GO:0017004)3.20474282
60positive regulation of mitochondrial fission (GO:0090141)3.19322844
61regulation of glucokinase activity (GO:0033131)3.19028408
62regulation of hexokinase activity (GO:1903299)3.19028408
63purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.15646321
64mannosylation (GO:0097502)3.15552611
65GPI anchor metabolic process (GO:0006505)3.14815545
66cullin deneddylation (GO:0010388)3.14067389
67DNA deamination (GO:0045006)3.12481431
68purine nucleoside triphosphate biosynthetic process (GO:0009145)3.12184910
69protein localization to mitochondrion (GO:0070585)3.10600899
70positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09057137
71ATP biosynthetic process (GO:0006754)3.08443648
72inner mitochondrial membrane organization (GO:0007007)3.07608796
73glycerophospholipid catabolic process (GO:0046475)3.07075406
74regulation of cellular amino acid metabolic process (GO:0006521)3.05113925
75lactate metabolic process (GO:0006089)3.05073545
76regulation of mitotic spindle checkpoint (GO:1903504)3.01750700
77regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01750700
78resolution of meiotic recombination intermediates (GO:0000712)2.97754545
79response to redox state (GO:0051775)2.97620807
80positive regulation of ligase activity (GO:0051351)2.97212150
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95371427
82positive regulation of histone H3-K4 methylation (GO:0051571)2.93919858
83myelination (GO:0042552)2.93156740
84replication fork processing (GO:0031297)2.90275583
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89109449
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89109449
87axon ensheathment (GO:0008366)2.86137774
88ensheathment of neurons (GO:0007272)2.86137774
89cholesterol biosynthetic process (GO:0006695)2.84200178
90regulation of meiosis I (GO:0060631)2.82171639
91DNA ligation (GO:0006266)2.81911193
92inositol phosphate catabolic process (GO:0071545)2.80117172
93regulation of mitochondrial translation (GO:0070129)2.80075206
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79027431
95negative regulation of ligase activity (GO:0051352)2.79027431
96DNA replication-independent nucleosome organization (GO:0034724)2.78839974
97DNA replication-independent nucleosome assembly (GO:0006336)2.78839974
98intracellular protein transmembrane import (GO:0044743)2.78674292
99protein K11-linked ubiquitination (GO:0070979)2.78339698
100phosphorylated carbohydrate dephosphorylation (GO:0046838)2.75855765
101inositol phosphate dephosphorylation (GO:0046855)2.75855765
102negative regulation of execution phase of apoptosis (GO:1900118)2.74572292
103negative regulation of DNA-dependent DNA replication (GO:2000104)2.74090112
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73872071
105regulation of cellular amine metabolic process (GO:0033238)2.73188759
106microtubule polymerization or depolymerization (GO:0031109)2.72276445
107aldehyde catabolic process (GO:0046185)2.71714287
108regulation of ubiquitin-protein transferase activity (GO:0051438)2.71107553
109branched-chain amino acid catabolic process (GO:0009083)2.70209498
110ribonucleoside triphosphate biosynthetic process (GO:0009201)2.69778306
111signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69368160
112signal transduction involved in DNA damage checkpoint (GO:0072422)2.69368160
113anterograde synaptic vesicle transport (GO:0048490)2.68806205
114metaphase plate congression (GO:0051310)2.68796000
115DNA catabolic process, exonucleolytic (GO:0000738)2.68317326
116neuron fate determination (GO:0048664)2.67507658
117intraciliary transport (GO:0042073)2.67431896
118neurotransmitter uptake (GO:0001504)2.67337964
119positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66933418
120signal transduction involved in cell cycle checkpoint (GO:0072395)2.66851730
121nonmotile primary cilium assembly (GO:0035058)2.66761993
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65603744
123positive regulation of cellular amine metabolic process (GO:0033240)2.65068506
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.64906230
125signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.64906230
126ATP hydrolysis coupled proton transport (GO:0015991)2.64298042
127energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.64298042
128organelle disassembly (GO:1903008)2.64091668
129regulation of ligase activity (GO:0051340)2.62807124
130mitotic metaphase plate congression (GO:0007080)2.62576985
131histone mRNA metabolic process (GO:0008334)2.62353713
132peptidyl-histidine modification (GO:0018202)2.61640758
133negative regulation of protein localization to cell surface (GO:2000009)2.61237841
134signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.60811913
135signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.60811913
136signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.60811913
137protein-cofactor linkage (GO:0018065)2.60730482
138UTP biosynthetic process (GO:0006228)2.60624746
139regulation of feeding behavior (GO:0060259)2.60044843
140oxidative phosphorylation (GO:0006119)2.59876419
141establishment of integrated proviral latency (GO:0075713)2.59135992
142regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59045874
143L-methionine salvage (GO:0071267)2.57336646
144L-methionine biosynthetic process (GO:0071265)2.57336646
145amino acid salvage (GO:0043102)2.57336646
146cellular ketone body metabolic process (GO:0046950)2.57228614
147protein localization to kinetochore (GO:0034501)2.57025936
148C-terminal protein lipidation (GO:0006501)2.56896151
149aerobic respiration (GO:0009060)2.55980090
150mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.54925012
151nucleotide transmembrane transport (GO:1901679)2.54413344
152isoprenoid biosynthetic process (GO:0008299)2.53566078
153mitochondrial transport (GO:0006839)2.53300768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.10592637
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.63880018
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.21911930
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15524382
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.82087180
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81821198
7GBX2_23144817_ChIP-Seq_PC3_Human2.71097591
8TAF15_26573619_Chip-Seq_HEK293_Human2.69775785
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64711199
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62094536
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57040373
12FUS_26573619_Chip-Seq_HEK293_Human2.47936536
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45568090
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45362018
15EZH2_22144423_ChIP-Seq_EOC_Human2.39715378
16ZNF274_21170338_ChIP-Seq_K562_Hela2.33928855
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33523781
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32414502
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23663591
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22437881
21VDR_22108803_ChIP-Seq_LS180_Human2.20106761
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14374595
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07581860
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.05605790
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89138219
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85255906
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84514742
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.83476238
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.82911886
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82636078
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81249287
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.80789759
33* SRF_21415370_ChIP-Seq_HL-1_Mouse1.79808971
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79027302
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77168470
36* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59170012
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57644518
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57602996
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56424968
40EWS_26573619_Chip-Seq_HEK293_Human1.54838794
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53029540
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52244802
43P300_19829295_ChIP-Seq_ESCs_Human1.48490240
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.47714975
45ER_23166858_ChIP-Seq_MCF-7_Human1.46606254
46FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.41841933
47VDR_23849224_ChIP-Seq_CD4+_Human1.40454203
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35884576
49RNF2_27304074_Chip-Seq_NSC_Mouse1.35568592
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34925663
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31439123
52ELK1_19687146_ChIP-ChIP_HELA_Human1.30226015
53TP53_22573176_ChIP-Seq_HFKS_Human1.29682906
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29680136
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.27768157
56DCP1A_22483619_ChIP-Seq_HELA_Human1.27106649
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.25408788
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22755229
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.22508831
60BCAT_22108803_ChIP-Seq_LS180_Human1.22269319
61HTT_18923047_ChIP-ChIP_STHdh_Human1.21439793
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19757569
63IRF1_19129219_ChIP-ChIP_H3396_Human1.19630071
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19497761
65IGF1R_20145208_ChIP-Seq_DFB_Human1.18254048
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.17795704
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17357093
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16441460
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15092787
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.15092787
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.15058307
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14354448
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12322241
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11658575
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11088219
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11023939
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.10892213
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10656146
79* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10470775
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10327433
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10007475
82P53_22387025_ChIP-Seq_ESCs_Mouse1.09584772
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09410517
84P300_18555785_Chip-Seq_ESCs_Mouse1.09354404
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.09059357
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08549209
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08190185
88JUN_21703547_ChIP-Seq_K562_Human1.07837385
89SOX2_18555785_Chip-Seq_ESCs_Mouse1.07678723
90* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07280114
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06796700
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.06494903
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06267388
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05674585
95GABP_19822575_ChIP-Seq_HepG2_Human1.05581171
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.04776834
97RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04382572
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.04303534
99* TTF2_22483619_ChIP-Seq_HELA_Human1.03953704
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03404308
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03013111
102NANOG_19829295_ChIP-Seq_ESCs_Human1.02676825
103SOX2_19829295_ChIP-Seq_ESCs_Human1.02676825
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.02414420
105KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02411137
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.02156850
107AR_25329375_ChIP-Seq_VCAP_Human1.01917825
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.01310558
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01262231
110AR_20517297_ChIP-Seq_VCAP_Human1.00866549
111SMAD4_21799915_ChIP-Seq_A2780_Human1.00664491
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00602361
113MYC_18940864_ChIP-ChIP_HL60_Human0.99932886
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.99880892
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98596118
116CBP_20019798_ChIP-Seq_JUKART_Human0.98596118
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98357526
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.98254956
119FOXP3_21729870_ChIP-Seq_TREG_Human0.97792756
120SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96688820
121KLF4_18555785_Chip-Seq_ESCs_Mouse0.96212725
122E2F7_22180533_ChIP-Seq_HELA_Human0.96122800
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95819860
124FOXM1_23109430_ChIP-Seq_U2OS_Human0.95770112
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95629405
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.95430858
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94102446
128TCF4_22108803_ChIP-Seq_LS180_Human0.94067441
129SALL4_22934838_ChIP-ChIP_CD34+_Human0.93821915
130LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93040120
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.92402723
132E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92007162
133OCT4_18555785_Chip-Seq_ESCs_Mouse0.89843122
134ZFX_18555785_Chip-Seq_ESCs_Mouse0.88601381
135KDM2B_26808549_Chip-Seq_REH_Human0.88533482
136SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87673207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.78411546
2MP0001529_abnormal_vocalization4.40507345
3MP0001905_abnormal_dopamine_level3.80460321
4MP0003195_calcinosis3.21834722
5MP0008058_abnormal_DNA_repair2.53667015
6MP0004270_analgesia2.38885173
7MP0003136_yellow_coat_color2.31704833
8MP0000920_abnormal_myelination2.26111073
9MP0001986_abnormal_taste_sensitivity2.26022631
10MP0004142_abnormal_muscle_tone2.21562558
11MP0002272_abnormal_nervous_system2.10609820
12MP0006276_abnormal_autonomic_nervous2.10515833
13MP0003718_maternal_effect2.05572590
14MP0005409_darkened_coat_color2.02210445
15MP0008877_abnormal_DNA_methylation1.98689055
16MP0003787_abnormal_imprinting1.98651479
17MP0005410_abnormal_fertilization1.97883697
18MP0002734_abnormal_mechanical_nocicepti1.95239910
19MP0005084_abnormal_gallbladder_morpholo1.93834826
20MP0001486_abnormal_startle_reflex1.91704587
21MP0004147_increased_porphyrin_level1.89983385
22MP0002736_abnormal_nociception_after1.88418513
23MP0010094_abnormal_chromosome_stability1.86598766
24MP0003950_abnormal_plasma_membrane1.86358209
25MP0001968_abnormal_touch/_nociception1.85059820
26MP0003011_delayed_dark_adaptation1.84897965
27MP0005171_absent_coat_pigmentation1.77981160
28MP0009046_muscle_twitch1.77791844
29MP0008789_abnormal_olfactory_epithelium1.76221822
30MP0002064_seizures1.75762374
31MP0001188_hyperpigmentation1.73164579
32MP0001485_abnormal_pinna_reflex1.71317154
33MP0003121_genomic_imprinting1.70130131
34MP0009745_abnormal_behavioral_response1.69008634
35MP0003122_maternal_imprinting1.68971681
36MP0006292_abnormal_olfactory_placode1.66698027
37MP0004742_abnormal_vestibular_system1.66516992
38MP0005646_abnormal_pituitary_gland1.66136502
39MP0005075_abnormal_melanosome_morpholog1.65623537
40MP0002572_abnormal_emotion/affect_behav1.65304695
41MP0005174_abnormal_tail_pigmentation1.63096646
42MP0009379_abnormal_foot_pigmentation1.60751987
43MP0001440_abnormal_grooming_behavior1.59607845
44MP0003635_abnormal_synaptic_transmissio1.55092324
45MP0001293_anophthalmia1.54945794
46MP0001984_abnormal_olfaction1.53287701
47MP0001501_abnormal_sleep_pattern1.49382294
48MP0003890_abnormal_embryonic-extraembry1.47631485
49MP0002735_abnormal_chemical_nociception1.47401682
50MP0003786_premature_aging1.46876277
51MP0002277_abnormal_respiratory_mucosa1.46694319
52MP0006035_abnormal_mitochondrial_morpho1.46196411
53MP0004924_abnormal_behavior1.44733510
54MP0005386_behavior/neurological_phenoty1.44733510
55MP0006072_abnormal_retinal_apoptosis1.43318202
56MP0006036_abnormal_mitochondrial_physio1.43002161
57MP0002139_abnormal_hepatobiliary_system1.42064763
58MP0002095_abnormal_skin_pigmentation1.41763659
59MP0005551_abnormal_eye_electrophysiolog1.41345207
60MP0002102_abnormal_ear_morphology1.40709351
61MP0002067_abnormal_sensory_capabilities1.40321318
62MP0002090_abnormal_vision1.39389479
63MP0000516_abnormal_urinary_system1.37626246
64MP0005367_renal/urinary_system_phenotyp1.37626246
65MP0006054_spinal_hemorrhage1.36975173
66MP0008875_abnormal_xenobiotic_pharmacok1.36457611
67MP0008260_abnormal_autophagy1.36073390
68MP0001970_abnormal_pain_threshold1.32381425
69MP0000566_synostosis1.32284905
70MP0005379_endocrine/exocrine_gland_phen1.30931987
71MP0002837_dystrophic_cardiac_calcinosis1.29949358
72MP0002909_abnormal_adrenal_gland1.27877239
73MP0000647_abnormal_sebaceous_gland1.27694263
74MP0001963_abnormal_hearing_physiology1.26848185
75MP0003646_muscle_fatigue1.26463711
76MP0002229_neurodegeneration1.26411776
77MP0002063_abnormal_learning/memory/cond1.25951437
78MP0005451_abnormal_body_composition1.25156144
79MP0002163_abnormal_gland_morphology1.25095918
80MP0000778_abnormal_nervous_system1.23479865
81MP0004957_abnormal_blastocyst_morpholog1.22822334
82MP0005645_abnormal_hypothalamus_physiol1.22362489
83MP0000372_irregular_coat_pigmentation1.22060112
84MP0003283_abnormal_digestive_organ1.21115368
85MP0002928_abnormal_bile_duct1.19528216
86MP0005423_abnormal_somatic_nervous1.19107295
87MP0008995_early_reproductive_senescence1.18876528
88MP0005394_taste/olfaction_phenotype1.18719258
89MP0005499_abnormal_olfactory_system1.18719258
90MP0005408_hypopigmentation1.16752094
91MP0004133_heterotaxia1.16594138
92MP0003693_abnormal_embryo_hatching1.15641260
93MP0005389_reproductive_system_phenotype1.15382399
94MP0002733_abnormal_thermal_nociception1.11633664
95MP0005187_abnormal_penis_morphology1.11593402
96MP0002160_abnormal_reproductive_system1.09319391
97MP0003329_amyloid_beta_deposits1.08008089
98MP0003315_abnormal_perineum_morphology1.07169016
99MP0005332_abnormal_amino_acid1.06157640
100MP0003632_abnormal_nervous_system1.05957537
101MP0002752_abnormal_somatic_nervous1.05640005
102MP0000026_abnormal_inner_ear1.04684902
103MP0000427_abnormal_hair_cycle1.04181747
104MP0008007_abnormal_cellular_replicative1.03578007
105MP0010386_abnormal_urinary_bladder1.03463377
106MP0002254_reproductive_system_inflammat1.03291492
107MP0001929_abnormal_gametogenesis1.01751568
108MP0003698_abnormal_male_reproductive0.99309683
109MP0004381_abnormal_hair_follicle0.99117742
110MP0001502_abnormal_circadian_rhythm0.98073696
111MP0002184_abnormal_innervation0.97991122
112MP0001764_abnormal_homeostasis0.97947356
113MP0000631_abnormal_neuroendocrine_gland0.97848728
114MP0003938_abnormal_ear_development0.97509744
115MP0008057_abnormal_DNA_replication0.97508727
116MP0004019_abnormal_vitamin_homeostasis0.97369649
117MP0003634_abnormal_glial_cell0.97142268
118MP0000569_abnormal_digit_pigmentation0.96426271
119MP0002638_abnormal_pupillary_reflex0.95861743
120MP0002882_abnormal_neuron_morphology0.95852537
121MP0002751_abnormal_autonomic_nervous0.94993560
122MP0003077_abnormal_cell_cycle0.94941120
123MP0002066_abnormal_motor_capabilities/c0.93374451
124MP0008932_abnormal_embryonic_tissue0.92811803
125MP0009780_abnormal_chondrocyte_physiolo0.91904111
126MP0001944_abnormal_pancreas_morphology0.91519711
127MP0005253_abnormal_eye_physiology0.91192953
128MP0003123_paternal_imprinting0.90999629
129MP0001324_abnormal_eye_pigmentation0.90887017
130MP0005636_abnormal_mineral_homeostasis0.90313679
131MP0002876_abnormal_thyroid_physiology0.89506449
132MP0001145_abnormal_male_reproductive0.88778755
133MP0001756_abnormal_urination0.88637636
134MP0000015_abnormal_ear_pigmentation0.88452723
135MP0003252_abnormal_bile_duct0.87875334
136MP0003806_abnormal_nucleotide_metabolis0.87041810
137MP0003186_abnormal_redox_activity0.86845724
138MP0001664_abnormal_digestion0.85243530
139MP0003690_abnormal_glial_cell0.84672078
140MP0001727_abnormal_embryo_implantation0.83639994
141MP0002557_abnormal_social/conspecific_i0.83279074
142MP0002693_abnormal_pancreas_physiology0.83249617
143MP0001919_abnormal_reproductive_system0.83001219
144MP0005391_vision/eye_phenotype0.82056500
145MP0005195_abnormal_posterior_eye0.81155613
146MP0002210_abnormal_sex_determination0.80942428
147MP0002653_abnormal_ependyma_morphology0.78927267
148MP0004859_abnormal_synaptic_plasticity0.78747259
149MP0009697_abnormal_copulation0.78339783
150MP0004036_abnormal_muscle_relaxation0.77749317
151MP0008569_lethality_at_weaning0.76696976
152MP0000653_abnormal_sex_gland0.74528228
153MP0000955_abnormal_spinal_cord0.73883125
154MP0002938_white_spotting0.73221719
155MP0003937_abnormal_limbs/digits/tail_de0.73111122
156MP0004215_abnormal_myocardial_fiber0.72111281
157MP0000462_abnormal_digestive_system0.71824443
158MP0002822_catalepsy0.71680205
159MP0004043_abnormal_pH_regulation0.71519485

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.03467798
2Abnormal mitochondria in muscle tissue (HP:0008316)5.31394230
3Mitochondrial inheritance (HP:0001427)5.20037746
4Progressive macrocephaly (HP:0004481)5.07597780
5Acute encephalopathy (HP:0006846)4.79080306
6Increased hepatocellular lipid droplets (HP:0006565)4.76023322
7Renal Fanconi syndrome (HP:0001994)4.39676668
8Increased CSF lactate (HP:0002490)4.35981186
9Lipid accumulation in hepatocytes (HP:0006561)4.29018936
10Hepatocellular necrosis (HP:0001404)4.23201383
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.04319618
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.80071459
133-Methylglutaconic aciduria (HP:0003535)3.71085115
14Parakeratosis (HP:0001036)3.69108127
15Increased serum pyruvate (HP:0003542)3.50153816
16Abnormality of glycolysis (HP:0004366)3.50153816
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.47703279
18Leukodystrophy (HP:0002415)3.47311677
19Hepatic necrosis (HP:0002605)3.43253323
20Optic disc pallor (HP:0000543)3.31721448
21Increased intramyocellular lipid droplets (HP:0012240)3.23573149
22Sensory axonal neuropathy (HP:0003390)3.12086183
23Exertional dyspnea (HP:0002875)3.08496451
24Exercise intolerance (HP:0003546)3.01461976
25Respiratory failure (HP:0002878)2.97335004
26Abnormality of renal resorption (HP:0011038)2.97157421
27Cerebral edema (HP:0002181)2.91159840
28Abnormality of midbrain morphology (HP:0002418)2.87295491
29Molar tooth sign on MRI (HP:0002419)2.87295491
30Pancreatic fibrosis (HP:0100732)2.77837913
31Focal motor seizures (HP:0011153)2.75703907
32Pancreatic cysts (HP:0001737)2.75071477
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72505010
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72505010
35Respiratory difficulties (HP:0002880)2.71728999
36Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.70832909
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.70832909
38Lactic acidosis (HP:0003128)2.69778038
39Increased serum lactate (HP:0002151)2.67672259
40Increased muscle lipid content (HP:0009058)2.67263730
41Abnormal hair whorl (HP:0010721)2.65016547
42Intestinal atresia (HP:0011100)2.64116409
43True hermaphroditism (HP:0010459)2.55670997
44Medial flaring of the eyebrow (HP:0010747)2.54788792
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.54019288
46Absent/shortened dynein arms (HP:0200106)2.54019288
47Congenital, generalized hypertrichosis (HP:0004540)2.51528988
48Hyperinsulinemic hypoglycemia (HP:0000825)2.50345235
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.50291568
50Abnormality of the labia minora (HP:0012880)2.48680034
51Hypoglycemic coma (HP:0001325)2.48346194
52Cerebral hypomyelination (HP:0006808)2.47132455
53Neuroendocrine neoplasm (HP:0100634)2.40170926
54Congenital ichthyosiform erythroderma (HP:0007431)2.37640106
55Lethargy (HP:0001254)2.32616900
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.32236820
57Hypoplasia of the fovea (HP:0007750)2.32236820
58Hyperglycinemia (HP:0002154)2.30681199
59Abnormal ciliary motility (HP:0012262)2.26331750
60X-linked dominant inheritance (HP:0001423)2.25515867
61Abnormality of vitamin B metabolism (HP:0004340)2.25465423
62Colon cancer (HP:0003003)2.24172949
63Vaginal atresia (HP:0000148)2.23830661
64Amniotic constriction ring (HP:0009775)2.23780534
65Abnormality of placental membranes (HP:0011409)2.23780534
66Hypoglycemic seizures (HP:0002173)2.23489531
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23442493
68Nephronophthisis (HP:0000090)2.22957637
69Abnormality of methionine metabolism (HP:0010901)2.22875803
70Atonic seizures (HP:0010819)2.22559282
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19891246
72Abnormal protein N-linked glycosylation (HP:0012347)2.19891246
73Abnormal protein glycosylation (HP:0012346)2.19891246
74Abnormal glycosylation (HP:0012345)2.19891246
75Gait imbalance (HP:0002141)2.18594276
76Microvesicular hepatic steatosis (HP:0001414)2.18067903
77Congenital primary aphakia (HP:0007707)2.17557229
78Hypothermia (HP:0002045)2.15687257
79Genital tract atresia (HP:0001827)2.15059845
80Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14568114
81Abnormal respiratory epithelium morphology (HP:0012253)2.14104283
82Abnormal respiratory motile cilium morphology (HP:0005938)2.14104283
83Ketoacidosis (HP:0001993)2.14042761
84Abnormality of the fovea (HP:0000493)2.12320427
85Abnormal respiratory motile cilium physiology (HP:0012261)2.10954120
86Meckel diverticulum (HP:0002245)2.10504779
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.10486953
88Pheochromocytoma (HP:0002666)2.09438037
89Adrenal hypoplasia (HP:0000835)2.08988851
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.07517482
91Neoplasm of the adrenal gland (HP:0100631)2.07484913
92Nephrogenic diabetes insipidus (HP:0009806)2.06441977
93Methylmalonic acidemia (HP:0002912)2.05322893
94Neurofibrillary tangles (HP:0002185)2.04836615
95Aplastic anemia (HP:0001915)2.04484309
96Septo-optic dysplasia (HP:0100842)2.04414084
97Abnormality of the ileum (HP:0001549)2.02102210
98Abnormality of cells of the erythroid lineage (HP:0012130)1.99198323
99Spastic paraparesis (HP:0002313)1.97569848
100Abnormality of chromosome stability (HP:0003220)1.96875781
101Patchy hypopigmentation of hair (HP:0011365)1.94134630
102Progressive inability to walk (HP:0002505)1.89278337
103Generalized aminoaciduria (HP:0002909)1.89204840
104Retinal dysplasia (HP:0007973)1.88984540
105Pancreatic islet-cell hyperplasia (HP:0004510)1.87890257
106Large for gestational age (HP:0001520)1.86560007
107Peripheral hypomyelination (HP:0007182)1.86439233
108Sclerocornea (HP:0000647)1.85701634
109Poor suck (HP:0002033)1.82462958
110Abnormality of the heme biosynthetic pathway (HP:0010472)1.81066782
111Progressive external ophthalmoplegia (HP:0000590)1.79401735
112Hypomagnesemia (HP:0002917)1.79241538
113Male pseudohermaphroditism (HP:0000037)1.78395805
114Abnormality of the renal medulla (HP:0100957)1.77576977
115Abnormality of the preputium (HP:0100587)1.77433149
116Abnormal biliary tract physiology (HP:0012439)1.76231538
117Bile duct proliferation (HP:0001408)1.76231538
118Oligodactyly (hands) (HP:0001180)1.75672258
119CNS hypomyelination (HP:0003429)1.75644470
120Median cleft lip (HP:0000161)1.74425829
121Epileptic encephalopathy (HP:0200134)1.73773516
122Renal cortical cysts (HP:0000803)1.73589669
123Glycosuria (HP:0003076)1.72693661
124Abnormality of urine glucose concentration (HP:0011016)1.72693661
125Methylmalonic aciduria (HP:0012120)1.72175688
126Type I transferrin isoform profile (HP:0003642)1.71967982
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.71878363
128Abnormality of the vitamin B12 metabolism (HP:0004341)1.71815195
129Limb dystonia (HP:0002451)1.70222978
130Supernumerary spleens (HP:0009799)1.70070566
131Abnormality of the pancreatic islet cells (HP:0006476)1.69839982
132Abnormality of endocrine pancreas physiology (HP:0012093)1.69839982
133Ketosis (HP:0001946)1.69766716
134Aplasia/hypoplasia of the uterus (HP:0008684)1.69609422
135Neoplasm of the adrenal cortex (HP:0100641)1.68530210
136Abnormal number of erythroid precursors (HP:0012131)1.68455670
137Optic nerve hypoplasia (HP:0000609)1.68425278
138Absent septum pellucidum (HP:0001331)1.68164201
139Gastrointestinal atresia (HP:0002589)1.67964156
140Short tibia (HP:0005736)1.67438982
141Abnormality of the renal cortex (HP:0011035)1.67085925
142Abnormality of the septum pellucidum (HP:0007375)1.66992459
143CNS demyelination (HP:0007305)1.66738714
144Birth length less than 3rd percentile (HP:0003561)1.66464391
145Hyperphosphaturia (HP:0003109)1.64652422
146Cerebral hemorrhage (HP:0001342)1.64416845
147Emotional lability (HP:0000712)1.61825936
148Hyperventilation (HP:0002883)1.61658665
149Septate vagina (HP:0001153)1.60504745
150Poor coordination (HP:0002370)1.58376194
151Autoamputation (HP:0001218)1.56744805
152Hypoplasia of the uterus (HP:0000013)1.56599021
153Delusions (HP:0000746)1.56497788
154Abnormality of the axillary hair (HP:0100134)1.55725077
155Abnormality of secondary sexual hair (HP:0009888)1.55725077
156Hypoplastic left heart (HP:0004383)1.55594635
157Myokymia (HP:0002411)1.55561531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.52520324
2FRK3.49228406
3MUSK3.44886671
4STK393.15867233
5PBK3.04451213
6VRK22.82030692
7ARAF2.75362490
8STK162.63510904
9TRIM282.58756369
10OXSR12.51142554
11MAP3K122.47308214
12TNIK2.43031146
13ZAK2.38548655
14WNK32.29003253
15BRSK22.19527906
16MAPKAPK52.14376835
17CDK192.11167966
18BCR2.00409373
19MAP4K21.99132001
20BRAF1.92447512
21MAP2K71.88132766
22NEK11.71962254
23EIF2AK11.71278666
24NME11.70034821
25BMPR1B1.67712773
26VRK11.67004990
27MST41.64484047
28EIF2AK31.60045648
29BUB11.57873359
30NEK61.55531173
31CDC71.49687370
32TTK1.42988670
33GRK11.40457716
34CCNB11.40376258
35CSNK1G31.38311945
36BMPR21.29003973
37GRK71.28952808
38LIMK11.28557946
39WNK41.24006097
40PNCK1.22613153
41PINK11.22439408
42ERBB31.22165177
43DYRK21.21268481
44MYLK1.20775759
45FGFR21.18859193
46CSNK1G11.18698034
47FGR1.18090061
48ADRBK21.13911448
49PLK41.13290790
50PLK11.12211730
51STK31.11321527
52MAPK131.11213910
53EPHA41.10567729
54TAF11.08319230
55BCKDK1.02013337
56ACVR1B0.98164074
57PIM20.98017920
58CAMK2B0.97733906
59CAMK2A0.96603946
60PLK20.94189621
61ERBB40.93651843
62MAP3K60.93209622
63GRK50.92425005
64MKNK10.91906615
65INSRR0.90580575
66RAF10.90479418
67CAMK2D0.87103541
68CSNK1G20.85140721
69STK240.84937843
70OBSCN0.83564066
71PKN10.83416289
72BRSK10.78095523
73PAK30.77147248
74MKNK20.76900621
75PASK0.76768330
76DYRK30.76765192
77SRPK10.75534440
78CDK30.75027608
79MAP3K130.74164677
80PRKCG0.73894146
81MAP3K40.73482410
82PRPF4B0.72668070
83PIK3CA0.72398968
84CSNK1A1L0.72193048
85CDK80.72140343
86CAMK2G0.68379639
87WEE10.66828646
88RPS6KA50.66083243
89TLK10.64156223
90ABL20.64144646
91TAOK30.61936884
92IRAK20.61094933
93MAPKAPK30.58805242
94NME20.58209146
95PRKCI0.56069788
96CDK180.55748027
97STK40.55506212
98PTK2B0.54373197
99IRAK40.54043299
100MOS0.54017551
101ROCK20.53805736
102NLK0.52798136
103CDK150.52148566
104CDK140.51845755
105ATR0.51827920
106PHKG10.50407225
107PHKG20.50407225
108PRKCE0.49475604
109CDK11A0.47148787
110AKT30.46385034
111PDK20.46178875
112ADRBK10.45030649
113STK38L0.44004974
114AURKB0.43925709
115PLK30.42867245
116MAP2K40.41282047
117NUAK10.41215183
118ATM0.41134793
119CSNK2A20.40956072
120PRKCQ0.40618219
121TXK0.40373710
122PRKACA0.39085819
123FER0.38901009
124YES10.38812235
125EIF2AK20.38217215
126AURKA0.37255271
127CSNK1A10.36759100
128CLK10.35644769
129MET0.35405515
130PRKG10.35281729
131RIPK40.34152847
132WNK10.34100314
133UHMK10.33948142
134CDK50.33436117
135TSSK60.33306824
136SGK4940.33038098
137SGK2230.33038098
138CSNK2A10.30940112
139DAPK10.30700016
140STK100.30139205
141NTRK30.29635933
142PRKACB0.29613673
143CHEK20.29534771
144TIE10.27137161
145FGFR10.26331930
146RPS6KA40.24855267

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.24712067
2Parkinsons disease_Homo sapiens_hsa050124.34839164
3Proteasome_Homo sapiens_hsa030503.64277074
4Protein export_Homo sapiens_hsa030603.40017894
5Alzheimers disease_Homo sapiens_hsa050103.31888443
6Huntingtons disease_Homo sapiens_hsa050163.15003352
7RNA polymerase_Homo sapiens_hsa030202.91989813
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.69258466
9Ribosome_Homo sapiens_hsa030102.53728530
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.44911134
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38258017
12Fatty acid elongation_Homo sapiens_hsa000622.33973757
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.33426594
14Collecting duct acid secretion_Homo sapiens_hsa049662.04509004
15Caffeine metabolism_Homo sapiens_hsa002322.04419862
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04417659
17Ether lipid metabolism_Homo sapiens_hsa005651.98381716
18Basal transcription factors_Homo sapiens_hsa030221.95646155
19Steroid biosynthesis_Homo sapiens_hsa001001.92692883
20Cardiac muscle contraction_Homo sapiens_hsa042601.92113831
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77632702
22Sulfur metabolism_Homo sapiens_hsa009201.55369567
23Nicotine addiction_Homo sapiens_hsa050331.50096261
24Butanoate metabolism_Homo sapiens_hsa006501.49332669
25Homologous recombination_Homo sapiens_hsa034401.33575009
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33567125
27Pyrimidine metabolism_Homo sapiens_hsa002401.33386247
28Linoleic acid metabolism_Homo sapiens_hsa005911.31151945
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29861684
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28306247
31Vibrio cholerae infection_Homo sapiens_hsa051101.26225021
32Sphingolipid metabolism_Homo sapiens_hsa006001.22693959
33Vitamin B6 metabolism_Homo sapiens_hsa007501.18511422
34RNA degradation_Homo sapiens_hsa030181.18423104
35Serotonergic synapse_Homo sapiens_hsa047261.17658661
36Rheumatoid arthritis_Homo sapiens_hsa053231.12848104
37Purine metabolism_Homo sapiens_hsa002301.12292843
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10365233
39One carbon pool by folate_Homo sapiens_hsa006701.08781753
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06853138
41Nucleotide excision repair_Homo sapiens_hsa034201.04202611
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03874614
43Non-homologous end-joining_Homo sapiens_hsa034501.03018039
44Arachidonic acid metabolism_Homo sapiens_hsa005901.02399106
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01398592
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99719383
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99591600
48Phototransduction_Homo sapiens_hsa047440.97873035
49Tryptophan metabolism_Homo sapiens_hsa003800.96218605
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.93823195
51Nitrogen metabolism_Homo sapiens_hsa009100.91084309
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86558925
53Selenocompound metabolism_Homo sapiens_hsa004500.86488714
54Metabolic pathways_Homo sapiens_hsa011000.80676575
55Spliceosome_Homo sapiens_hsa030400.79715314
56Mismatch repair_Homo sapiens_hsa034300.79222271
57GABAergic synapse_Homo sapiens_hsa047270.79076992
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78684672
59DNA replication_Homo sapiens_hsa030300.76434240
60Fanconi anemia pathway_Homo sapiens_hsa034600.76115352
61Morphine addiction_Homo sapiens_hsa050320.75305901
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75295844
63Synaptic vesicle cycle_Homo sapiens_hsa047210.73847872
64Glutathione metabolism_Homo sapiens_hsa004800.72473875
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72020207
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71727339
67Regulation of autophagy_Homo sapiens_hsa041400.71274865
68Chemical carcinogenesis_Homo sapiens_hsa052040.68884657
69Glutamatergic synapse_Homo sapiens_hsa047240.66256142
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65225266
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64345344
72beta-Alanine metabolism_Homo sapiens_hsa004100.63968116
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63008278
74Fatty acid degradation_Homo sapiens_hsa000710.62025318
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61725464
76Retinol metabolism_Homo sapiens_hsa008300.61463250
77Folate biosynthesis_Homo sapiens_hsa007900.60008084
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59119159
79Long-term depression_Homo sapiens_hsa047300.58525859
80Pyruvate metabolism_Homo sapiens_hsa006200.58339096
81Fatty acid metabolism_Homo sapiens_hsa012120.56792107
82Taste transduction_Homo sapiens_hsa047420.56301005
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55535081
84Amphetamine addiction_Homo sapiens_hsa050310.55360841
85Autoimmune thyroid disease_Homo sapiens_hsa053200.53932563
86N-Glycan biosynthesis_Homo sapiens_hsa005100.51637470
87Dopaminergic synapse_Homo sapiens_hsa047280.48847394
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46755195
89p53 signaling pathway_Homo sapiens_hsa041150.45532924
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45115167
91Circadian entrainment_Homo sapiens_hsa047130.43751092
92Phagosome_Homo sapiens_hsa041450.43647589
93Circadian rhythm_Homo sapiens_hsa047100.43635802
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.42576472
95Cocaine addiction_Homo sapiens_hsa050300.42088475
96Ovarian steroidogenesis_Homo sapiens_hsa049130.40830863
97Cell cycle_Homo sapiens_hsa041100.36246696
98Allograft rejection_Homo sapiens_hsa053300.35035164
99RNA transport_Homo sapiens_hsa030130.34810477
100Calcium signaling pathway_Homo sapiens_hsa040200.34498388
101Insulin secretion_Homo sapiens_hsa049110.33416867
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.32991629
103Oocyte meiosis_Homo sapiens_hsa041140.32041794
104Base excision repair_Homo sapiens_hsa034100.31899870
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31683931
106Histidine metabolism_Homo sapiens_hsa003400.31349984
107Vitamin digestion and absorption_Homo sapiens_hsa049770.30079391
108Alcoholism_Homo sapiens_hsa050340.27836277
109Axon guidance_Homo sapiens_hsa043600.27103058
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.27073344
111Asthma_Homo sapiens_hsa053100.26903931
112Long-term potentiation_Homo sapiens_hsa047200.25618419
113Graft-versus-host disease_Homo sapiens_hsa053320.24863995
114Olfactory transduction_Homo sapiens_hsa047400.24808679
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.24364845
116Arginine and proline metabolism_Homo sapiens_hsa003300.23069274
117Propanoate metabolism_Homo sapiens_hsa006400.22804941
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22318302
119Peroxisome_Homo sapiens_hsa041460.21975859
120Renin secretion_Homo sapiens_hsa049240.21671010
121Salivary secretion_Homo sapiens_hsa049700.21470830
122Carbon metabolism_Homo sapiens_hsa012000.21011495
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20918763
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.20767832
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20307451
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19448548
127Epstein-Barr virus infection_Homo sapiens_hsa051690.18580873
128Mineral absorption_Homo sapiens_hsa049780.16517146
129Tyrosine metabolism_Homo sapiens_hsa003500.16030796
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15047334
131Cholinergic synapse_Homo sapiens_hsa047250.14418155
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.13013422
133Ras signaling pathway_Homo sapiens_hsa040140.12234128
134African trypanosomiasis_Homo sapiens_hsa051430.11954001

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