TMEM61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1inositol phosphate catabolic process (GO:0071545)4.69931013
2phosphorylated carbohydrate dephosphorylation (GO:0046838)4.63631762
3inositol phosphate dephosphorylation (GO:0046855)4.63631762
4detection of calcium ion (GO:0005513)4.61686161
5endocrine pancreas development (GO:0031018)4.60965431
6insulin secretion (GO:0030073)4.53971909
7peptide hormone processing (GO:0016486)4.39060006
8auditory receptor cell differentiation (GO:0042491)4.27779184
9glycerophospholipid catabolic process (GO:0046475)4.06324780
10negative regulation of execution phase of apoptosis (GO:1900118)4.03590442
11positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.89707258
12nitric oxide biosynthetic process (GO:0006809)3.84523223
13polyol catabolic process (GO:0046174)3.81728633
14positive regulation of insulin secretion (GO:0032024)3.79548576
15regulation of type B pancreatic cell apoptotic process (GO:2000674)3.75157307
16cellular ketone body metabolic process (GO:0046950)3.72888714
17positive regulation of glycolytic process (GO:0045821)3.70946227
18positive regulation of gluconeogenesis (GO:0045722)3.51491026
19glandular epithelial cell differentiation (GO:0002067)3.49815759
20regulation of acrosome reaction (GO:0060046)3.38132351
21positive regulation of peptide hormone secretion (GO:0090277)3.37207116
22L-alpha-amino acid transmembrane transport (GO:1902475)3.32634162
23regulation of glucokinase activity (GO:0033131)3.31548257
24regulation of hexokinase activity (GO:1903299)3.31548257
25positive regulation of histone H3-K4 methylation (GO:0051571)3.31323771
26positive regulation of calcium ion import (GO:0090280)3.29647719
27regulation of extracellular matrix disassembly (GO:0010715)3.27518705
28ketone body metabolic process (GO:1902224)3.25580047
29positive regulation of peptide secretion (GO:0002793)3.24440717
30macroautophagy (GO:0016236)3.23202314
31nitric oxide mediated signal transduction (GO:0007263)3.22950648
32peptide hormone secretion (GO:0030072)3.16253619
33epithelial cilium movement (GO:0003351)3.14172057
34regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.11400777
35sphingomyelin metabolic process (GO:0006684)3.10829427
36axoneme assembly (GO:0035082)3.04730737
37regulation of oxidative phosphorylation (GO:0002082)3.04571624
38peptide secretion (GO:0002790)3.04439039
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.03806692
40retrograde transport, vesicle recycling within Golgi (GO:0000301)3.03127307
41pteridine-containing compound biosynthetic process (GO:0042559)3.02083015
42regulation of insulin secretion (GO:0050796)3.00490591
43regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.00056939
44epithelial cell fate commitment (GO:0072148)2.99619110
45negative regulation of dendrite development (GO:2000171)2.99313654
46negative regulation of complement activation (GO:0045916)2.94364653
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91341535
48L-phenylalanine catabolic process (GO:0006559)2.91341535
49type B pancreatic cell development (GO:0003323)2.89813582
50regulation of protein glycosylation (GO:0060049)2.89391051
51protein targeting to Golgi (GO:0000042)2.89348823
52heme transport (GO:0015886)2.87014141
53phenylpropanoid metabolic process (GO:0009698)2.86450392
54cytochrome complex assembly (GO:0017004)2.85251454
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82508356
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.80805352
57L-phenylalanine metabolic process (GO:0006558)2.80805352
58regulation of acyl-CoA biosynthetic process (GO:0050812)2.80661941
59chemosensory behavior (GO:0007635)2.79161433
60regulation of autophagic vacuole assembly (GO:2000785)2.78937028
61signal peptide processing (GO:0006465)2.78043107
62respiratory chain complex IV assembly (GO:0008535)2.78014872
63regulation of peptide hormone secretion (GO:0090276)2.76913814
64inositol phosphate-mediated signaling (GO:0048016)2.75859939
65negative regulation of neurological system process (GO:0031645)2.75311448
66establishment of protein localization to Golgi (GO:0072600)2.75170752
67negative regulation of dendrite morphogenesis (GO:0050774)2.75068471
68glucosamine-containing compound catabolic process (GO:1901072)2.73758465
69retinol metabolic process (GO:0042572)2.71679600
70keratinocyte development (GO:0003334)2.71051379
71regulation of peptide secretion (GO:0002791)2.70282441
72cilium movement (GO:0003341)2.69787194
73calcium ion import (GO:0070509)2.69267677
74desmosome organization (GO:0002934)2.68314855
75cellular response to vitamin D (GO:0071305)2.67903530
76positive regulation of hormone secretion (GO:0046887)2.62831313
77response to pheromone (GO:0019236)2.60054876
78zinc ion homeostasis (GO:0055069)2.59528458
79catecholamine transport (GO:0051937)2.59086258
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58939909
81intra-Golgi vesicle-mediated transport (GO:0006891)2.58914221
82hormone secretion (GO:0046879)2.57874320
83negative regulation of protein activation cascade (GO:2000258)2.56990732
84COPII vesicle coating (GO:0048208)2.56175405
85artery smooth muscle contraction (GO:0014824)2.54433616
86regulation of neurotransmitter uptake (GO:0051580)2.54425436
87regulation of hormone secretion (GO:0046883)2.53178823
88peptide transport (GO:0015833)2.52594819
89regulation of heart rate by cardiac conduction (GO:0086091)2.51566566
90negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51260850
91positive regulation of glucose metabolic process (GO:0010907)2.50874743
92negative regulation of gluconeogenesis (GO:0045721)2.49889118
93positive regulation of nitric-oxide synthase activity (GO:0051000)2.49363212
94calcium ion-dependent exocytosis (GO:0017156)2.47549555
95intestinal epithelial cell development (GO:0060576)2.47405130
96coenzyme catabolic process (GO:0009109)2.47385722
97positive regulation of neurotransmitter transport (GO:0051590)2.47353289
98hormone transport (GO:0009914)2.45838900
99neuron fate specification (GO:0048665)2.45270763
100iron coordination entity transport (GO:1901678)2.45152351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.96017643
2GBX2_23144817_ChIP-Seq_PC3_Human2.98052349
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18343828
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05324733
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98878377
6ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97678421
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82890561
8EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.79781837
9AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75994300
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74507044
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71831880
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67188767
13PIAS1_25552417_ChIP-Seq_VCAP_Human1.62382019
14HTT_18923047_ChIP-ChIP_STHdh_Human1.61890842
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.58697359
16SMAD4_21799915_ChIP-Seq_A2780_Human1.56029094
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55905872
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55012164
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53034720
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52589905
21RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50778404
22FUS_26573619_Chip-Seq_HEK293_Human1.49335708
23ZNF274_21170338_ChIP-Seq_K562_Hela1.47366518
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46741371
25BCAT_22108803_ChIP-Seq_LS180_Human1.45400085
26NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44852737
27IGF1R_20145208_ChIP-Seq_DFB_Human1.41152416
28P300_19829295_ChIP-Seq_ESCs_Human1.37861186
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34546479
30FOXA1_25552417_ChIP-Seq_VCAP_Human1.34251267
31CDX2_22108803_ChIP-Seq_LS180_Human1.33724448
32ER_23166858_ChIP-Seq_MCF-7_Human1.32960793
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32183270
34AR_25329375_ChIP-Seq_VCAP_Human1.31873206
35FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.30969270
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30253075
37* SMAD3_21741376_ChIP-Seq_EPCs_Human1.30199853
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30037521
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28057113
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25874626
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24435966
42STAT3_23295773_ChIP-Seq_U87_Human1.24034637
43* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23277606
44* FOXA1_25329375_ChIP-Seq_VCAP_Human1.23277606
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.21721143
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.20157629
47REST_21632747_ChIP-Seq_MESCs_Mouse1.19827626
48TCF4_23295773_ChIP-Seq_U87_Human1.19798228
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19667455
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19498771
51SOX2_20726797_ChIP-Seq_SW620_Human1.19395248
52TCF4_22108803_ChIP-Seq_LS180_Human1.18597866
53SOX2_18555785_Chip-Seq_ESCs_Mouse1.15251585
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13987910
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13905344
56EWS_26573619_Chip-Seq_HEK293_Human1.13324273
57SOX2_19829295_ChIP-Seq_ESCs_Human1.10706289
58NANOG_19829295_ChIP-Seq_ESCs_Human1.10706289
59* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10422823
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10318945
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.10079204
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08927450
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07162088
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06822470
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.06518972
66VDR_22108803_ChIP-Seq_LS180_Human1.06508448
67TP53_22573176_ChIP-Seq_HFKS_Human1.05249920
68P53_22387025_ChIP-Seq_ESCs_Mouse1.05034707
69CBP_20019798_ChIP-Seq_JUKART_Human1.02978637
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02978637
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.02944442
72* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01783120
73CTCF_18555785_Chip-Seq_ESCs_Mouse1.01469992
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01386896
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01374169
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01361270
77RUNX2_22187159_ChIP-Seq_PCA_Human1.00711702
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.00709430
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00147445
80NCOR_22424771_ChIP-Seq_293T_Human0.99383482
81NFE2_27457419_Chip-Seq_LIVER_Mouse0.99342634
82SMAD3_21741376_ChIP-Seq_HESCs_Human0.98934190
83AR_20517297_ChIP-Seq_VCAP_Human0.97893992
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97607155
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97357818
86TAL1_26923725_Chip-Seq_HPCs_Mouse0.96773768
87* PHF8_20622853_ChIP-Seq_HELA_Human0.96720313
88PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96583775
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96487326
90AHR_22903824_ChIP-Seq_MCF-7_Human0.96231249
91CBX2_27304074_Chip-Seq_ESCs_Mouse0.95779024
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94402506
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93849425
94NMYC_18555785_Chip-Seq_ESCs_Mouse0.93529711
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93222933
96E2F1_18555785_Chip-Seq_ESCs_Mouse0.92932840
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92841932
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92419174
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91289774
100* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91027053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.71854301
2MP0005379_endocrine/exocrine_gland_phen3.98762289
3MP0003195_calcinosis3.98099036
4MP0010234_abnormal_vibrissa_follicle3.86144065
5MP0002909_abnormal_adrenal_gland3.60294735
6MP0009780_abnormal_chondrocyte_physiolo3.37090322
7MP0005645_abnormal_hypothalamus_physiol3.21412406
8MP0002139_abnormal_hepatobiliary_system3.18252129
9MP0002163_abnormal_gland_morphology3.11381829
10MP0003787_abnormal_imprinting3.07552163
11MP0000013_abnormal_adipose_tissue3.03855128
12MP0001944_abnormal_pancreas_morphology2.80061133
13MP0006072_abnormal_retinal_apoptosis2.62423582
14MP0002693_abnormal_pancreas_physiology2.58291340
15MP0005646_abnormal_pituitary_gland2.34044568
16MP0004019_abnormal_vitamin_homeostasis2.24750398
17MP0004270_analgesia2.23532649
18MP0003283_abnormal_digestive_organ2.19750477
19MP0002876_abnormal_thyroid_physiology2.10966778
20MP0008877_abnormal_DNA_methylation2.07850716
21MP0003172_abnormal_lysosome_physiology1.92542264
22MP0003123_paternal_imprinting1.81461861
23MP0002254_reproductive_system_inflammat1.78674113
24MP0005332_abnormal_amino_acid1.71344057
25MP0005174_abnormal_tail_pigmentation1.69752138
26MP0009046_muscle_twitch1.69695629
27MP0005220_abnormal_exocrine_pancreas1.66874821
28MP0005075_abnormal_melanosome_morpholog1.66561284
29MP0002078_abnormal_glucose_homeostasis1.59325880
30MP0010386_abnormal_urinary_bladder1.52923906
31MP0003122_maternal_imprinting1.51357833
32MP0000015_abnormal_ear_pigmentation1.50686872
33MP0003879_abnormal_hair_cell1.49116862
34MP0001756_abnormal_urination1.46534393
35MP0010678_abnormal_skin_adnexa1.43601873
36MP0005551_abnormal_eye_electrophysiolog1.40708769
37MP0005636_abnormal_mineral_homeostasis1.40640858
38MP0001765_abnormal_ion_homeostasis1.40110590
39MP0001501_abnormal_sleep_pattern1.37995585
40MP0000003_abnormal_adipose_tissue1.35409644
41MP0010329_abnormal_lipoprotein_level1.31301051
42MP0000569_abnormal_digit_pigmentation1.22433000
43MP0003953_abnormal_hormone_level1.20714707
44MP0005253_abnormal_eye_physiology1.20198089
45MP0002938_white_spotting1.19057525
46MP0002138_abnormal_hepatobiliary_system1.16442880
47MP0000372_irregular_coat_pigmentation1.15468223
48MP0000631_abnormal_neuroendocrine_gland1.14929924
49MP0005084_abnormal_gallbladder_morpholo1.14746365
50MP0001664_abnormal_digestion1.09721097
51MP0005377_hearing/vestibular/ear_phenot1.08224055
52MP0003878_abnormal_ear_physiology1.08224055
53MP0004043_abnormal_pH_regulation1.07221848
54MP0002090_abnormal_vision1.02894925
55MP0002734_abnormal_mechanical_nocicepti0.99615491
56MP0003786_premature_aging0.98400980
57MP0005448_abnormal_energy_balance0.96465219
58MP0002638_abnormal_pupillary_reflex0.95696510
59MP0003121_genomic_imprinting0.95440347
60MP0009745_abnormal_behavioral_response0.94681701
61MP0005535_abnormal_body_temperature0.93510587
62MP0002168_other_aberrant_phenotype0.93471526
63MP0003186_abnormal_redox_activity0.92042994
64MP0004133_heterotaxia0.91717673
65MP0001905_abnormal_dopamine_level0.89649636
66MP0003011_delayed_dark_adaptation0.89445245
67MP0000427_abnormal_hair_cycle0.86826744
68MP0004215_abnormal_myocardial_fiber0.86062332
69MP0002272_abnormal_nervous_system0.84994395
70MP0004885_abnormal_endolymph0.84836409
71MP0000383_abnormal_hair_follicle0.84363512
72MP0002229_neurodegeneration0.83497087
73MP0002118_abnormal_lipid_homeostasis0.82506532
74MP0002295_abnormal_pulmonary_circulatio0.82238384
75MP0005248_abnormal_Harderian_gland0.82134274
76MP0002557_abnormal_social/conspecific_i0.81807288
77MP0003633_abnormal_nervous_system0.81572651
78MP0005187_abnormal_penis_morphology0.81501219
79MP0009643_abnormal_urine_homeostasis0.80536905
80MP0001502_abnormal_circadian_rhythm0.79752271
81MP0003868_abnormal_feces_composition0.79521680
82MP0004085_abnormal_heartbeat0.79130306
83MP0001984_abnormal_olfaction0.79073280
84MP0005365_abnormal_bile_salt0.77702075
85MP0002064_seizures0.75397495
86MP0005395_other_phenotype0.73893063
87MP0000639_abnormal_adrenal_gland0.71401382
88MP0003045_fibrosis0.70940508
89MP0002928_abnormal_bile_duct0.69531707
90MP0002971_abnormal_brown_adipose0.67588787
91MP0005408_hypopigmentation0.63930796
92MP0000647_abnormal_sebaceous_gland0.63861454
93MP0005389_reproductive_system_phenotype0.63821239
94MP0000230_abnormal_systemic_arterial0.63199702
95MP0002160_abnormal_reproductive_system0.62728217
96MP0005375_adipose_tissue_phenotype0.60633028
97MP0006036_abnormal_mitochondrial_physio0.60216761
98MP0005085_abnormal_gallbladder_physiolo0.60168880
99MP0001986_abnormal_taste_sensitivity0.58979901
100MP0008872_abnormal_physiological_respon0.58777870

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)4.59435077
2Hyperinsulinemic hypoglycemia (HP:0000825)4.47788137
3Hyperglycemia (HP:0003074)4.44925043
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.44313498
5Hypoglycemic coma (HP:0001325)4.19952686
6Ketoacidosis (HP:0001993)4.02133902
7Late onset (HP:0003584)3.74107930
8Hypothermia (HP:0002045)3.71475778
9Hyperphosphatemia (HP:0002905)3.68897794
10Congenital malformation of the right heart (HP:0011723)3.60039451
11Double outlet right ventricle (HP:0001719)3.60039451
12Intestinal atresia (HP:0011100)3.58591207
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.47197124
14Large for gestational age (HP:0001520)3.28265693
15Increased circulating renin level (HP:0000848)3.20500627
16Abnormality of vitamin B metabolism (HP:0004340)3.18321749
17Pigmentary retinal degeneration (HP:0001146)3.13493006
18Vascular calcification (HP:0004934)3.06805551
19Abnormality of endocrine pancreas physiology (HP:0012093)2.99007702
20Abnormality of the pancreatic islet cells (HP:0006476)2.99007702
21Enlarged penis (HP:0000040)2.97559623
22Symptomatic seizures (HP:0011145)2.95182983
23Abnormal pancreas size (HP:0012094)2.88055957
24Insulin-resistant diabetes mellitus (HP:0000831)2.88052854
25Hypomagnesemia (HP:0002917)2.80499569
26Ketosis (HP:0001946)2.77296886
27Postural tremor (HP:0002174)2.75302982
28Abnormality of vitamin metabolism (HP:0100508)2.75197768
29Metaphyseal dysplasia (HP:0100255)2.68270554
30Abnormal drinking behavior (HP:0030082)2.62424927
31Polydipsia (HP:0001959)2.62424927
32Cardiovascular calcification (HP:0011915)2.58793174
33Increased CSF protein (HP:0002922)2.57719612
34Hypoplasia of the uterus (HP:0000013)2.53907288
35Pancreatic fibrosis (HP:0100732)2.53241225
36Progressive macrocephaly (HP:0004481)2.51750105
37EEG with generalized epileptiform discharges (HP:0011198)2.50961737
38Hemiparesis (HP:0001269)2.49882907
39Aplasia/hypoplasia of the uterus (HP:0008684)2.49039627
40Methylmalonic acidemia (HP:0002912)2.43818288
41Epileptiform EEG discharges (HP:0011182)2.43253902
42Abnormality of calcium-phosphate metabolism (HP:0100530)2.31974429
43Abnormality of magnesium homeostasis (HP:0004921)2.30485055
44Albinism (HP:0001022)2.29538041
45Hypsarrhythmia (HP:0002521)2.29379456
46Abnormality of the renal cortex (HP:0011035)2.28944322
47Acute necrotizing encephalopathy (HP:0006965)2.26880561
48Hyperthyroidism (HP:0000836)2.23636707
49Progressive neurologic deterioration (HP:0002344)2.22693799
50Abnormality of renin-angiotensin system (HP:0000847)2.19712132
51Neoplasm of the adrenal cortex (HP:0100641)2.18942040
52Abnormality of renal excretion (HP:0011036)2.18276107
53Glycosuria (HP:0003076)2.16044928
54Abnormality of urine glucose concentration (HP:0011016)2.16044928
55Orthostatic hypotension (HP:0001278)2.15536837
56Molar tooth sign on MRI (HP:0002419)2.14847278
57Abnormality of midbrain morphology (HP:0002418)2.14847278
58Abnormal albumin level (HP:0012116)2.14142639
59Hypoalbuminemia (HP:0003073)2.14142639
60Pancreatic cysts (HP:0001737)2.12457017
61Abnormal ciliary motility (HP:0012262)2.10422158
62Tubular atrophy (HP:0000092)2.08397207
63Rhinitis (HP:0012384)2.07206500
64Abnormal respiratory epithelium morphology (HP:0012253)2.05272378
65Abnormal respiratory motile cilium morphology (HP:0005938)2.05272378
66Gastrointestinal atresia (HP:0002589)2.04860436
67Pancreatic islet-cell hyperplasia (HP:0004510)2.03659198
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.03391848
69Hypoplasia of the fovea (HP:0007750)2.03391848
70Furrowed tongue (HP:0000221)2.02218717
71Medial flaring of the eyebrow (HP:0010747)2.01485239
72Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98920249
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98920249
74Tongue fasciculations (HP:0001308)1.98849760
75Methylmalonic aciduria (HP:0012120)1.98601646
76Agitation (HP:0000713)1.97420246
77Muscular hypotonia of the trunk (HP:0008936)1.96665720
78Tetany (HP:0001281)1.96434477
79Nephronophthisis (HP:0000090)1.94624553
80Hypokinesia (HP:0002375)1.93204687
81Abnormality of renal resorption (HP:0011038)1.93023572
82Hepatic necrosis (HP:0002605)1.92622580
83Polyuria (HP:0000103)1.92536421
84Abnormal respiratory motile cilium physiology (HP:0012261)1.91309754
85Syncope (HP:0001279)1.91168484
86Aqueductal stenosis (HP:0002410)1.85633243
87Prominent metopic ridge (HP:0005487)1.84138648
88Mitochondrial inheritance (HP:0001427)1.83946645
89Insulin resistance (HP:0000855)1.83345332
90Hyperphosphaturia (HP:0003109)1.82361788
91Abnormal mitochondria in muscle tissue (HP:0008316)1.80572827
92Testicular neoplasm (HP:0010788)1.80391262
93Abnormal biliary tract morphology (HP:0012440)1.79571781
94Vacuolated lymphocytes (HP:0001922)1.78771181
95Abnormality of the renal medulla (HP:0100957)1.78153993
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.78075545
97Abnormality of the fovea (HP:0000493)1.77920811
98Tachypnea (HP:0002789)1.75761236
99Acute encephalopathy (HP:0006846)1.74150145
100Choroideremia (HP:0001139)1.73944294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.48014776
2MAP4K24.15085925
3MST44.03704046
4PINK13.28267960
5PHKG13.04226116
6PHKG23.04226116
7DAPK22.74948334
8FGFR22.59122442
9GRK12.46733806
10WNK32.34031460
11STK242.30444753
12PRKD32.13408241
13NTRK32.01387170
14MAP3K121.75382788
15FER1.64479989
16ACVR1B1.62494127
17ADRBK21.59839463
18MAP2K61.58226025
19MAP3K21.53595429
20EPHA21.53184961
21PRKCE1.34939712
22UHMK11.33680666
23STK38L1.27398762
24PTK2B1.24985413
25TRPM71.24019239
26PAK31.21904356
27WNK41.19900087
28FGFR31.14404298
29MAP3K41.12820557
30STK391.10766137
31CSNK1G11.09520646
32PRKCI1.05715664
33STK31.05591945
34CASK1.03338041
35INSRR1.03068369
36MAP3K90.99320321
37PRKG20.97857210
38OXSR10.96644502
39CAMK2D0.96431865
40YES10.89684546
41MST1R0.84680346
42HIPK20.83539594
43MYLK0.82348663
44CSNK1G30.82344919
45PASK0.81858128
46PRKCG0.80121010
47BMPR1B0.78905495
48PTK20.75248271
49PLK20.73040667
50DAPK10.71923697
51CSNK1G20.69520727
52PRKD20.68951380
53TRIM280.68533895
54ERBB30.66254974
55BRD40.65446018
56PRKAA10.64752731
57AKT20.61649497
58TAOK10.60563475
59NLK0.59451422
60MAPK150.57917041
61ADRBK10.57878357
62TESK10.57664624
63PRKAA20.56537905
64STK160.50639753
65MET0.50156311
66STK110.48781010
67PRKCQ0.48069553
68CSNK1A10.47890744
69LIMK10.47234137
70LATS10.46851710
71IRAK20.46731592
72CAMK2A0.46187527
73STK380.45899252
74MAP3K10.45251376
75ZAK0.44484715
76LMTK20.43094439
77PRKACA0.41074734
78TNK20.40095919
79PRKCZ0.39982016
80GRK70.39933734
81CSNK1A1L0.39123361
82ILK0.37915275
83PRKCH0.37711115
84PRKCA0.37479398
85FLT30.36312594
86MAPK130.35854260
87SGK2230.34944511
88SGK4940.34944511
89SGK20.34525882
90NME10.33269325
91PDK10.33172185
92CHUK0.32825387
93PRKG10.32046924
94OBSCN0.31530855
95CSNK1E0.30743254
96IRAK10.28788351
97CSNK1D0.27913239
98PRKACB0.27868042
99SGK10.27398384
100GSK3A0.27374756

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.66118534
2Insulin secretion_Homo sapiens_hsa049112.77008216
3Sulfur metabolism_Homo sapiens_hsa009202.50333556
4Folate biosynthesis_Homo sapiens_hsa007902.50078545
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.28796726
6Butanoate metabolism_Homo sapiens_hsa006502.04812239
7Protein export_Homo sapiens_hsa030602.02891670
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95817605
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94364553
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.93558160
11Arginine biosynthesis_Homo sapiens_hsa002201.76599905
12Oxidative phosphorylation_Homo sapiens_hsa001901.75153377
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72208918
14Collecting duct acid secretion_Homo sapiens_hsa049661.70013826
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62251428
16Sphingolipid metabolism_Homo sapiens_hsa006001.49842916
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44482882
18Renin secretion_Homo sapiens_hsa049241.43708894
19Circadian rhythm_Homo sapiens_hsa047101.36251648
20Type I diabetes mellitus_Homo sapiens_hsa049401.35817662
21Synaptic vesicle cycle_Homo sapiens_hsa047211.35669662
22Phototransduction_Homo sapiens_hsa047441.34870361
23Selenocompound metabolism_Homo sapiens_hsa004501.32605273
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32404275
25Vitamin B6 metabolism_Homo sapiens_hsa007501.29088459
26Fatty acid elongation_Homo sapiens_hsa000621.25634913
27beta-Alanine metabolism_Homo sapiens_hsa004101.23035656
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19891317
29Ether lipid metabolism_Homo sapiens_hsa005651.17172118
30Mineral absorption_Homo sapiens_hsa049781.15020069
31Histidine metabolism_Homo sapiens_hsa003401.13309553
32Peroxisome_Homo sapiens_hsa041461.13292657
33Linoleic acid metabolism_Homo sapiens_hsa005911.12893426
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09046379
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07010957
36Vibrio cholerae infection_Homo sapiens_hsa051101.05933040
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05721511
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05339005
39ABC transporters_Homo sapiens_hsa020101.04405850
40Glucagon signaling pathway_Homo sapiens_hsa049221.03984046
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02527435
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00563049
43Type II diabetes mellitus_Homo sapiens_hsa049301.00198587
44Amphetamine addiction_Homo sapiens_hsa050310.98807073
45Circadian entrainment_Homo sapiens_hsa047130.98483968
46Dorso-ventral axis formation_Homo sapiens_hsa043200.92805226
47Serotonergic synapse_Homo sapiens_hsa047260.91375250
48Salivary secretion_Homo sapiens_hsa049700.91240166
49Other glycan degradation_Homo sapiens_hsa005110.90145899
50Alzheimers disease_Homo sapiens_hsa050100.89549916
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.89355504
52Dopaminergic synapse_Homo sapiens_hsa047280.87567926
53Regulation of autophagy_Homo sapiens_hsa041400.87550039
54GABAergic synapse_Homo sapiens_hsa047270.87219027
55Tryptophan metabolism_Homo sapiens_hsa003800.86048434
56Chemical carcinogenesis_Homo sapiens_hsa052040.85978751
57Glutathione metabolism_Homo sapiens_hsa004800.84682008
58Long-term depression_Homo sapiens_hsa047300.83729259
59Ovarian steroidogenesis_Homo sapiens_hsa049130.82872018
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82713349
61Parkinsons disease_Homo sapiens_hsa050120.80916527
62Retinol metabolism_Homo sapiens_hsa008300.78660435
63N-Glycan biosynthesis_Homo sapiens_hsa005100.77730620
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75160680
65Arachidonic acid metabolism_Homo sapiens_hsa005900.74895395
66Propanoate metabolism_Homo sapiens_hsa006400.72870492
67Pancreatic secretion_Homo sapiens_hsa049720.72568630
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.71911225
69Glutamatergic synapse_Homo sapiens_hsa047240.71553325
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70636303
71Starch and sucrose metabolism_Homo sapiens_hsa005000.69057095
72Metabolic pathways_Homo sapiens_hsa011000.68611308
73Cocaine addiction_Homo sapiens_hsa050300.66730654
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66621704
75Caffeine metabolism_Homo sapiens_hsa002320.66555605
76Arginine and proline metabolism_Homo sapiens_hsa003300.64737647
77Cardiac muscle contraction_Homo sapiens_hsa042600.62003541
78Tight junction_Homo sapiens_hsa045300.61309756
79Nitrogen metabolism_Homo sapiens_hsa009100.60799454
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60356902
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.60036614
82Lysosome_Homo sapiens_hsa041420.58741781
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53842553
84Vitamin digestion and absorption_Homo sapiens_hsa049770.53643106
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51782329
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.50221398
87Fatty acid degradation_Homo sapiens_hsa000710.49305155
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48965298
89Gastric acid secretion_Homo sapiens_hsa049710.46363445
90Huntingtons disease_Homo sapiens_hsa050160.45863631
91Thyroid hormone synthesis_Homo sapiens_hsa049180.44616223
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.43684970
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43027820
94Tyrosine metabolism_Homo sapiens_hsa003500.42587231
95Phenylalanine metabolism_Homo sapiens_hsa003600.42062618
96Fatty acid metabolism_Homo sapiens_hsa012120.40705400
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40138528
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37485364
99Taste transduction_Homo sapiens_hsa047420.37212025
100Morphine addiction_Homo sapiens_hsa050320.36863645

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