TMEM62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.37622341
2central nervous system myelination (GO:0022010)5.37622341
3fatty acid elongation (GO:0030497)5.01190987
4neuronal action potential propagation (GO:0019227)4.01523991
5type I interferon signaling pathway (GO:0060337)3.79770707
6cellular response to type I interferon (GO:0071357)3.79770707
7response to type I interferon (GO:0034340)3.76824091
8long-chain fatty acid biosynthetic process (GO:0042759)3.69253818
9L-phenylalanine catabolic process (GO:0006559)3.59581357
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.59581357
11negative regulation of neurotransmitter transport (GO:0051589)3.52664461
12response to peptidoglycan (GO:0032494)3.51469064
13neuromuscular process controlling posture (GO:0050884)3.43366424
14iron coordination entity transport (GO:1901678)3.41239662
15regulation of T cell tolerance induction (GO:0002664)3.40715226
16neuron cell-cell adhesion (GO:0007158)3.39987498
17synaptic vesicle exocytosis (GO:0016079)3.37369520
18negative regulation of interleukin-8 production (GO:0032717)3.35012104
19heme transport (GO:0015886)3.32697512
20regulation of tolerance induction (GO:0002643)3.31626663
21gamma-aminobutyric acid transport (GO:0015812)3.26326053
22L-phenylalanine metabolic process (GO:0006558)3.25234848
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.25234848
24negative regulation of neurotransmitter secretion (GO:0046929)3.25197358
25regulation of synaptic vesicle exocytosis (GO:2000300)3.22004014
26axon ensheathment (GO:0008366)3.19153972
27ensheathment of neurons (GO:0007272)3.19153972
28myelination (GO:0042552)3.17660552
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15895895
30cerebellar granule cell differentiation (GO:0021707)3.14384617
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.12256232
32L-amino acid import (GO:0043092)3.09739658
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09638415
34long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.07149419
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.06786765
36cholesterol biosynthetic process (GO:0006695)3.06353618
37immunoglobulin mediated immune response (GO:0016064)3.03588470
38neurotransmitter catabolic process (GO:0042135)3.03470457
39creatine metabolic process (GO:0006600)2.97990193
40glycerophospholipid catabolic process (GO:0046475)2.94944180
41interferon-gamma-mediated signaling pathway (GO:0060333)2.92048987
42locomotory exploration behavior (GO:0035641)2.91273414
43glutamate secretion (GO:0014047)2.90165437
44ionotropic glutamate receptor signaling pathway (GO:0035235)2.90083595
45glutamate receptor signaling pathway (GO:0007215)2.89287890
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.88112218
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87535012
48adult walking behavior (GO:0007628)2.86457812
49macrophage activation involved in immune response (GO:0002281)2.85197735
50fatty-acyl-CoA biosynthetic process (GO:0046949)2.83809091
51glycosphingolipid catabolic process (GO:0046479)2.82301918
52angiotensin maturation (GO:0002003)2.81165964
53positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.80887497
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.80568195
55cellular response to exogenous dsRNA (GO:0071360)2.80408443
56regulation of B cell receptor signaling pathway (GO:0050855)2.79663359
57presynaptic membrane organization (GO:0097090)2.79555589
58regulation of interferon-beta biosynthetic process (GO:0045357)2.78009857
59long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.77765091
60regulation of interferon-alpha production (GO:0032647)2.76351690
61transmission of nerve impulse (GO:0019226)2.74614994
62presynaptic membrane assembly (GO:0097105)2.73717629
63cellular response to ethanol (GO:0071361)2.73400979
64negative regulation of interleukin-12 production (GO:0032695)2.71744758
65regulation of synaptic vesicle transport (GO:1902803)2.71309740
66regulation of collateral sprouting (GO:0048670)2.70868414
67regulation of amyloid precursor protein catabolic process (GO:1902991)2.70850876
68sterol biosynthetic process (GO:0016126)2.70741850
69positive regulation of interferon-alpha production (GO:0032727)2.69893648
70interferon-gamma secretion (GO:0072643)2.69001699
71positive regulation by symbiont of host defense response (GO:0052509)2.68758685
72modulation by symbiont of host defense response (GO:0052031)2.68758685
73modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68758685
74modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68758685
75positive regulation by organism of defense response of other organism involved in symbiotic interact2.68758685
76modulation by symbiont of host immune response (GO:0052553)2.68758685
77glycosylceramide metabolic process (GO:0006677)2.68461250
78establishment of mitochondrion localization (GO:0051654)2.68038525
79glycolipid catabolic process (GO:0019377)2.66210883
80synaptic vesicle maturation (GO:0016188)2.65130848
81lipopolysaccharide-mediated signaling pathway (GO:0031663)2.65068015
82positive regulation of type 2 immune response (GO:0002830)2.64780453
83fatty-acyl-CoA metabolic process (GO:0035337)2.64491821
84germinal center formation (GO:0002467)2.64044903
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64030174
86cellular potassium ion homeostasis (GO:0030007)2.63696124
87CDP-diacylglycerol metabolic process (GO:0046341)2.62929564
88thioester biosynthetic process (GO:0035384)2.62661114
89acyl-CoA biosynthetic process (GO:0071616)2.62661114
90neurotransmitter secretion (GO:0007269)2.61687486
91energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61051646
92ATP hydrolysis coupled proton transport (GO:0015991)2.61051646
93mating behavior (GO:0007617)2.60174911
94negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60166342
95neuron-neuron synaptic transmission (GO:0007270)2.59152567
96response to protozoan (GO:0001562)2.58804626
97antigen processing and presentation of endogenous antigen (GO:0019883)2.58653003
98response to methylmercury (GO:0051597)2.58017612
99vocalization behavior (GO:0071625)2.57934657
100acidic amino acid transport (GO:0015800)2.57436042
101positive regulation of gamma-delta T cell activation (GO:0046645)2.57371877
102L-glutamate transport (GO:0015813)2.57166496
103very long-chain fatty acid metabolic process (GO:0000038)2.55172056
104peptide catabolic process (GO:0043171)2.54451745
105T cell migration (GO:0072678)2.54434061
106regulation of beta-amyloid formation (GO:1902003)2.54207200
107potassium ion import (GO:0010107)2.52171921
108behavioral response to cocaine (GO:0048148)2.51676473
109neurotransmitter transport (GO:0006836)2.50702335
110myelin maintenance (GO:0043217)2.50126246
111C4-dicarboxylate transport (GO:0015740)2.49949691
112positive regulation of toll-like receptor signaling pathway (GO:0034123)2.49468060
113synaptic transmission, glutamatergic (GO:0035249)2.49148740
114long-term memory (GO:0007616)2.48616688
115transferrin transport (GO:0033572)2.48560600
116negative regulation of protein localization to cell surface (GO:2000009)2.47800302
117positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46061308
118neurotransmitter uptake (GO:0001504)2.45235115
119detection of molecule of bacterial origin (GO:0032490)2.44367445
120negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.43535820
121glutathione biosynthetic process (GO:0006750)2.43063126
122defense response to protozoan (GO:0042832)2.42412202
123regulation of neurotransmitter levels (GO:0001505)2.41339825
124regulation of mast cell activation involved in immune response (GO:0033006)2.41213964
125regulation of type 2 immune response (GO:0002828)2.41039150
126myeloid dendritic cell differentiation (GO:0043011)2.41007591
127positive regulation of leukocyte degranulation (GO:0043302)2.40258624
128apical protein localization (GO:0045176)2.40077109
129substantia nigra development (GO:0021762)2.39129203
130positive regulation of cellular amine metabolic process (GO:0033240)2.38190749
131ER overload response (GO:0006983)2.37982488
132iron ion import (GO:0097286)2.36701612
133amino acid import (GO:0043090)2.36633443
134long-term synaptic potentiation (GO:0060291)2.36191873
135regulation of T-helper 2 cell differentiation (GO:0045628)2.35374979
136regulation of necroptotic process (GO:0060544)2.34746567
137response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.32728919
138response to host immune response (GO:0052572)2.32728919
139trivalent inorganic cation transport (GO:0072512)2.32569746
140ferric iron transport (GO:0015682)2.32569746
141regulation of synapse structural plasticity (GO:0051823)2.32508878
142detection of other organism (GO:0098543)2.32337136
143B cell receptor signaling pathway (GO:0050853)2.32121307
144aromatic amino acid family catabolic process (GO:0009074)2.31727386
145positive regulation of cellular amide metabolic process (GO:0034250)2.31651951
146negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.31351443
147mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.31311113
148neuron remodeling (GO:0016322)2.31285964
149negative regulation of synaptic transmission (GO:0050805)2.29129807
150regulation of leukocyte degranulation (GO:0043300)2.28961857
151negative regulation of macroautophagy (GO:0016242)2.28447309
152protein targeting to lysosome (GO:0006622)2.27846698
153establishment of protein localization to vacuole (GO:0072666)2.27846698
154protein targeting to vacuole (GO:0006623)2.27846698
155mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.27828283
156positive regulation of membrane potential (GO:0045838)2.27211627
157coenzyme catabolic process (GO:0009109)2.26988270
158regulation of type I interferon-mediated signaling pathway (GO:0060338)2.26686390
159regulation of phospholipid biosynthetic process (GO:0071071)2.26126293
160autophagic vacuole fusion (GO:0000046)2.25951297
161positive regulation of Cdc42 GTPase activity (GO:0043089)2.25765142
162carnitine transmembrane transport (GO:1902603)2.25760907
163regulation of mast cell degranulation (GO:0043304)2.25284459
164T-helper 1 type immune response (GO:0042088)2.25243208
165negative regulation of type 2 immune response (GO:0002829)2.25118683
166regulation of interleukin-8 biosynthetic process (GO:0045414)2.24670621
167regulation of chemokine biosynthetic process (GO:0045073)2.24635922
168mature B cell differentiation involved in immune response (GO:0002313)2.24443704
169mature B cell differentiation (GO:0002335)2.23980398
170regulation of vitamin metabolic process (GO:0030656)2.23416150
171very-low-density lipoprotein particle assembly (GO:0034379)2.23270560
172regulation of T-helper 1 cell differentiation (GO:0045625)2.22829856
173cellular extravasation (GO:0045123)2.22120072
174neutrophil activation involved in immune response (GO:0002283)2.21391062
175regulation of toll-like receptor signaling pathway (GO:0034121)2.21075640
176response to host (GO:0075136)2.20171205
177response to host defenses (GO:0052200)2.20171205
178response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.20171205
179detection of bacterium (GO:0016045)2.20167432
180cellular response to interferon-gamma (GO:0071346)2.19675527
181positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.18993693
182positive regulation of chemokine biosynthetic process (GO:0045080)2.18774778
183regulation of myeloid leukocyte mediated immunity (GO:0002886)2.18754690
184oligosaccharide catabolic process (GO:0009313)2.18579330
185cellular response to interferon-alpha (GO:0035457)2.18448692
186negative regulation of myeloid cell apoptotic process (GO:0033033)2.17819479
187ceramide catabolic process (GO:0046514)2.16161653
188regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.15933757
189detection of external biotic stimulus (GO:0098581)2.15885539
190macroautophagy (GO:0016236)2.15569777
191negative regulation of toll-like receptor signaling pathway (GO:0034122)2.15355317
192carnitine transport (GO:0015879)2.15303291
193amino-acid betaine transport (GO:0015838)2.15303291
194positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.15234668
195dendritic cell differentiation (GO:0097028)2.14761170
196sphingosine metabolic process (GO:0006670)2.14632066
197hepatocyte apoptotic process (GO:0097284)2.13173640
198negative regulation of humoral immune response (GO:0002921)2.10812507
199regulation of necrotic cell death (GO:0010939)2.10138862
200NIK/NF-kappaB signaling (GO:0038061)2.09611674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human6.32216088
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.87810987
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.27375551
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.12461327
5GBX2_23144817_ChIP-Seq_PC3_Human2.94515621
6EZH2_22144423_ChIP-Seq_EOC_Human2.91858496
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.68238107
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60411184
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.58831563
10TAF15_26573619_Chip-Seq_HEK293_Human2.52999565
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51385359
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.46997908
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45913703
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42599182
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.34303902
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32621745
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.32410230
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.32243576
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22502581
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21840258
21REST_21632747_ChIP-Seq_MESCs_Mouse2.20750021
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19276716
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17758158
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17198110
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17128903
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13574211
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09901181
28JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07225526
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.99527205
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98547626
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.90918002
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88103313
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.87191457
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80316851
35DROSHA_22980978_ChIP-Seq_HELA_Human1.79161750
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76418035
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75482052
38SPI1_23127762_ChIP-Seq_K562_Human1.75156187
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73710189
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.71996183
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70330237
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68734278
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67530639
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67530639
45GATA1_22025678_ChIP-Seq_K562_Human1.65665196
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64533786
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62723157
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61753929
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60343996
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59204264
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.57801437
52* SOX2_20726797_ChIP-Seq_SW620_Human1.57669277
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56414196
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55557879
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.54030973
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53949895
57* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52943412
58VDR_24763502_ChIP-Seq_THP-1_Human1.51783768
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49072616
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48915585
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47960567
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47729111
63VDR_22108803_ChIP-Seq_LS180_Human1.47433308
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47386972
65SPI1_23547873_ChIP-Seq_NB4_Human1.46758084
66* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46085352
67AR_21572438_ChIP-Seq_LNCaP_Human1.45543920
68VDR_24787735_ChIP-Seq_THP-1_Human1.45166644
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.43228270
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42448445
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42295688
72VDR_21846776_ChIP-Seq_THP-1_Human1.41881420
73MYB_26560356_Chip-Seq_TH2_Human1.40600145
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.39103795
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37259171
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.36616580
77* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36138503
78ER_23166858_ChIP-Seq_MCF-7_Human1.35172556
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34024919
80LXR_22158963_ChIP-Seq_LIVER_Mouse1.33676815
81ZNF263_19887448_ChIP-Seq_K562_Human1.33339736
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.32658831
83RUNX_20019798_ChIP-Seq_JUKART_Human1.32488213
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.30549166
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.30462882
86TP63_17297297_ChIP-ChIP_HaCaT_Human1.30444591
87MYB_26560356_Chip-Seq_TH1_Human1.29779178
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29339204
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28902551
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.27920726
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27792115
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27548304
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27492478
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24969300
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.24758105
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.24714852
97* RUNX1_22412390_ChIP-Seq_EML_Mouse1.24560275
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24416441
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24091692
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23689326
101HTT_18923047_ChIP-ChIP_STHdh_Human1.23426277
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23351200
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.22570023
104SMAD4_21799915_ChIP-Seq_A2780_Human1.22361145
105GATA6_25053715_ChIP-Seq_YYC3_Human1.22022115
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21638139
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19445616
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18295492
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18295492
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18286315
111SCL_19346495_ChIP-Seq_HPC-7_Human1.17444501
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15692287
113* GATA4_25053715_ChIP-Seq_YYC3_Human1.15161919
114POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14822662
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14288312
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14145648
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.13379249
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12497097
119MAF_26560356_Chip-Seq_TH1_Human1.11738686
120STAT3_23295773_ChIP-Seq_U87_Human1.11669459
121P300_19829295_ChIP-Seq_ESCs_Human1.11538262
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11222667
123NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10959373
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09941973
125EOMES_21245162_ChIP-Seq_HESCs_Human1.08680618
126ZNF274_21170338_ChIP-Seq_K562_Hela1.08021501
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07405671
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07307482
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07067179
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05936145
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05524024
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.05239021
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05183289
134KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04920392
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04567525
136PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03809149
137GATA3_27048872_Chip-Seq_THYMUS_Human1.03524074
138RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02545671
139RACK7_27058665_Chip-Seq_MCF-7_Human1.02340558
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02249924
141TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01698613
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01366470
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00933918
144GATA1_19941826_ChIP-Seq_K562_Human1.00828615
145SMAD3_21741376_ChIP-Seq_EPCs_Human1.00508842
146SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00115664
147ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00114588
148PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00022803
149CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99557285
150GATA2_19941826_ChIP-Seq_K562_Human0.98423480
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96591807
152AR_25329375_ChIP-Seq_VCAP_Human0.96509548
153RUNX1_27514584_Chip-Seq_MCF-7_Human0.96254046
154JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95399112
155JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94729993
156PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94724753
157* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93907915
158GATA3_26560356_Chip-Seq_TH2_Human0.93761996
159TCF4_23295773_ChIP-Seq_U87_Human0.93087414
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92962222
161LXR_22292898_ChIP-Seq_THP-1_Human0.92718072
162SOX2_19829295_ChIP-Seq_ESCs_Human0.92697011
163NANOG_19829295_ChIP-Seq_ESCs_Human0.92697011
164NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92466799
165NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92466799
166MAF_26560356_Chip-Seq_TH2_Human0.91722538
167AHR_22903824_ChIP-Seq_MCF-7_Human0.90942861
168ARNT_22903824_ChIP-Seq_MCF-7_Human0.88950007
169* SMAD4_21741376_ChIP-Seq_EPCs_Human0.88628111
170FOXH1_21741376_ChIP-Seq_ESCs_Human0.87352303
171CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86579520
172NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86123375
173GATA1_26923725_Chip-Seq_HPCs_Mouse0.86026948
174PRDM14_20953172_ChIP-Seq_ESCs_Human0.84933042
175GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84529983
176NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83658033
177JUN_21703547_ChIP-Seq_K562_Human0.83596754
178RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83373473
179KDM2B_26808549_Chip-Seq_REH_Human0.82905943
180THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82342657
181TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82054251
182NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81901559
183TET1_21490601_ChIP-Seq_MESCs_Mouse0.81899841
184GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81680989
185NCOR_22424771_ChIP-Seq_293T_Human0.81256581
186FOXA2_19822575_ChIP-Seq_HepG2_Human0.79952408
187RUNX2_22187159_ChIP-Seq_PCA_Human0.79343006
188TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79129440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.03832215
2MP0004859_abnormal_synaptic_plasticity3.74523038
3MP0003329_amyloid_beta_deposits3.52840808
4MP0003303_peritoneal_inflammation3.43748341
5MP0004270_analgesia3.22514771
6MP0000920_abnormal_myelination2.97320106
7MP0009046_muscle_twitch2.93464776
8MP0001835_abnormal_antigen_presentation2.89835925
9MP0003183_abnormal_peptide_metabolism2.88912026
10MP0006082_CNS_inflammation2.85245182
11MP0002064_seizures2.76842389
12MP0009840_abnormal_foam_cell2.76806512
13MP0003635_abnormal_synaptic_transmissio2.73054428
14MP0003195_calcinosis2.62647831
15MP0002272_abnormal_nervous_system2.51498816
16MP0009785_altered_susceptibility_to2.41697742
17MP0010234_abnormal_vibrissa_follicle2.41098672
18MP0003191_abnormal_cellular_cholesterol2.40524204
19MP0009745_abnormal_behavioral_response2.36598709
20MP0002139_abnormal_hepatobiliary_system2.35610717
21MP0003724_increased_susceptibility_to2.26819055
22MP0005423_abnormal_somatic_nervous2.20796083
23MP0002148_abnormal_hypersensitivity_rea2.19202339
24MP0002734_abnormal_mechanical_nocicepti2.18837407
25MP0005387_immune_system_phenotype2.16697032
26MP0001790_abnormal_immune_system2.16697032
27MP0000604_amyloidosis2.15273686
28MP0001440_abnormal_grooming_behavior2.13311836
29MP0003436_decreased_susceptibility_to2.11173127
30MP0004043_abnormal_pH_regulation2.11102808
31MP0005025_abnormal_response_to2.04931985
32MP0002063_abnormal_learning/memory/cond2.04849529
33MP0003690_abnormal_glial_cell2.04413378
34MP0003300_gastrointestinal_ulcer2.02130475
35MP0001501_abnormal_sleep_pattern2.01164986
36MP0002572_abnormal_emotion/affect_behav1.96838776
37MP0001486_abnormal_startle_reflex1.96051054
38MP0010155_abnormal_intestine_physiology1.95913161
39MP0008875_abnormal_xenobiotic_pharmacok1.94238138
40MP0002419_abnormal_innate_immunity1.93663640
41MP0001800_abnormal_humoral_immune1.91633775
42MP0004142_abnormal_muscle_tone1.91390339
43MP0005000_abnormal_immune_tolerance1.81578956
44MP0001968_abnormal_touch/_nociception1.80441501
45MP0004264_abnormal_extraembryonic_tissu1.80278462
46MP0000685_abnormal_immune_system1.78154049
47MP0002452_abnormal_antigen_presenting1.77866207
48MP0003172_abnormal_lysosome_physiology1.76229985
49MP0001905_abnormal_dopamine_level1.74711819
50MP0001529_abnormal_vocalization1.74086709
51MP0002723_abnormal_immune_serum1.69271610
52MP0002067_abnormal_sensory_capabilities1.66891288
53MP0008569_lethality_at_weaning1.65277889
54MP0002735_abnormal_chemical_nociception1.64476762
55MP0005058_abnormal_lysosome_morphology1.64288496
56MP0005332_abnormal_amino_acid1.64103694
57MP0005360_urolithiasis1.64055210
58MP0002138_abnormal_hepatobiliary_system1.63933687
59MP0008260_abnormal_autophagy1.59791081
60MP0001970_abnormal_pain_threshold1.59454617
61MP0003632_abnormal_nervous_system1.57483556
62MP0005365_abnormal_bile_salt1.56427757
63MP0004885_abnormal_endolymph1.55885436
64MP0005451_abnormal_body_composition1.55878132
65MP0004924_abnormal_behavior1.55469853
66MP0005386_behavior/neurological_phenoty1.55469853
67MP0002822_catalepsy1.55241480
68MP0001845_abnormal_inflammatory_respons1.54779653
69MP0003634_abnormal_glial_cell1.54512404
70MP0005464_abnormal_platelet_physiology1.52967876
71MP0002229_neurodegeneration1.52556375
72MP0005671_abnormal_response_to1.52302374
73MP0001819_abnormal_immune_cell1.52060462
74MP0002420_abnormal_adaptive_immunity1.51670684
75MP0001873_stomach_inflammation1.50958175
76MP0002736_abnormal_nociception_after1.50752014
77MP0005085_abnormal_gallbladder_physiolo1.50248705
78MP0004742_abnormal_vestibular_system1.45612369
79MP0002733_abnormal_thermal_nociception1.42754452
80MP0008469_abnormal_protein_level1.41744770
81MP0003763_abnormal_thymus_physiology1.38769704
82MP0005166_decreased_susceptibility_to1.37476523
83MP0002876_abnormal_thyroid_physiology1.36508895
84MP0005083_abnormal_biliary_tract1.36081355
85MP0003631_nervous_system_phenotype1.35551939
86MP0004947_skin_inflammation1.34604807
87MP0003656_abnormal_erythrocyte_physiolo1.34372363
88MP0002405_respiratory_system_inflammati1.29860862
89MP0009764_decreased_sensitivity_to1.29532476
90MP0002066_abnormal_motor_capabilities/c1.28839606
91MP0003633_abnormal_nervous_system1.27495955
92MP0003075_altered_response_to1.25531979
93MP0003950_abnormal_plasma_membrane1.24188526
94MP0002166_altered_tumor_susceptibility1.23804725
95MP0009333_abnormal_splenocyte_physiolog1.19956487
96MP0000778_abnormal_nervous_system1.19642600
97MP0003879_abnormal_hair_cell1.18354533
98MP0005551_abnormal_eye_electrophysiolog1.17572137
99MP0008004_abnormal_stomach_pH1.16185609
100MP0000955_abnormal_spinal_cord1.16071877
101MP0002184_abnormal_innervation1.16063412
102MP0001666_abnormal_nutrient_absorption1.15902721
103MP0000013_abnormal_adipose_tissue1.15628592
104MP0001533_abnormal_skeleton_physiology1.15027811
105MP0000716_abnormal_immune_system1.12119654
106MP0004510_myositis1.10891407
107MP0003252_abnormal_bile_duct1.09976819
108MP0002118_abnormal_lipid_homeostasis1.09097367
109MP0005164_abnormal_response_to1.06763621
110MP0001661_extended_life_span1.04480825
111MP0000465_gastrointestinal_hemorrhage1.03873175
112MP0005535_abnormal_body_temperature1.02780423
113MP0003045_fibrosis1.02592663
114MP0002332_abnormal_exercise_endurance1.02246334
115MP0002882_abnormal_neuron_morphology1.02155296
116MP0004381_abnormal_hair_follicle1.02098850
117MP0000609_abnormal_liver_physiology1.01306915
118MP0009643_abnormal_urine_homeostasis1.00731007
119MP0003866_abnormal_defecation0.99808557
120MP0003453_abnormal_keratinocyte_physiol0.98849651
121MP0005645_abnormal_hypothalamus_physiol0.98734497
122MP0010678_abnormal_skin_adnexa0.98655889
123MP0002132_abnormal_respiratory_system0.98385594
124MP0010329_abnormal_lipoprotein_level0.97800150
125MP0006276_abnormal_autonomic_nervous0.97607949
126MP0002998_abnormal_bone_remodeling0.97460396
127MP0002090_abnormal_vision0.96639641
128MP0008872_abnormal_physiological_respon0.96420938
129MP0001986_abnormal_taste_sensitivity0.95104583
130MP0002398_abnormal_bone_marrow0.94452634
131MP0004019_abnormal_vitamin_homeostasis0.93770433
132MP0005397_hematopoietic_system_phenotyp0.93592521
133MP0001545_abnormal_hematopoietic_system0.93592521
134MP0005319_abnormal_enzyme/_coenzyme0.93525322
135MP0002557_abnormal_social/conspecific_i0.92551979
136MP0002877_abnormal_melanocyte_morpholog0.90259568
137MP0000747_muscle_weakness0.90190206
138MP0001765_abnormal_ion_homeostasis0.89541014
139MP0000343_altered_response_to0.89427989
140MP0001502_abnormal_circadian_rhythm0.89158670
141MP0000858_altered_metastatic_potential0.88648849
142MP0004811_abnormal_neuron_physiology0.88457587
143MP0005310_abnormal_salivary_gland0.88430578
144MP0002006_tumorigenesis0.87148889
145MP0002429_abnormal_blood_cell0.84559408
146MP0004883_abnormal_blood_vessel0.84290666
147MP0001663_abnormal_digestive_system0.83625505
148MP0000647_abnormal_sebaceous_gland0.83442597
149MP0002909_abnormal_adrenal_gland0.83412751
150MP0009763_increased_sensitivity_to0.83207111
151MP0003091_abnormal_cell_migration0.82719767
152MP0004145_abnormal_muscle_electrophysio0.81613653
153MP0001177_atelectasis0.81522853
154MP0005584_abnormal_enzyme/coenzyme_acti0.81107077
155MP0003868_abnormal_feces_composition0.79633264
156MP0002136_abnormal_kidney_physiology0.76881974
157MP0005666_abnormal_adipose_tissue0.76664424
158MP0002971_abnormal_brown_adipose0.76226999
159MP0005165_increased_susceptibility_to0.75482470
160MP0002069_abnormal_eating/drinking_beha0.74643846
161MP0000249_abnormal_blood_vessel0.74369134
162MP0001963_abnormal_hearing_physiology0.71237640
163MP0009780_abnormal_chondrocyte_physiolo0.71076811
164MP0009115_abnormal_fat_cell0.70492279
165MP0000689_abnormal_spleen_morphology0.69975624
166MP0008874_decreased_physiological_sensi0.69783415
167MP0000383_abnormal_hair_follicle0.69599050
168MP0003806_abnormal_nucleotide_metabolis0.69108957
169MP0002722_abnormal_immune_system0.69050295
170MP0000579_abnormal_nail_morphology0.68640242
171MP0001664_abnormal_digestion0.68163620
172MP0001984_abnormal_olfaction0.68135952
173MP0001756_abnormal_urination0.65311403
174MP0001485_abnormal_pinna_reflex0.64699288
175MP0002152_abnormal_brain_morphology0.62081570

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.16095693
2Focal motor seizures (HP:0011153)4.26749680
3Cerebral inclusion bodies (HP:0100314)4.09440985
4Supranuclear gaze palsy (HP:0000605)3.72779151
5Myokymia (HP:0002411)3.60151390
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.50210545
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.40551358
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.40551358
9Dysostosis multiplex (HP:0000943)3.40057526
10Urinary glycosaminoglycan excretion (HP:0003541)3.30845284
11Mucopolysacchariduria (HP:0008155)3.30845284
12Abnormality of mucopolysaccharide metabolism (HP:0011020)3.27025037
13Abnormality of polysaccharide metabolism (HP:0011012)3.27025037
14Abnormality of glycosaminoglycan metabolism (HP:0004371)3.27025037
15Hyperlipoproteinemia (HP:0010980)3.26614950
16Abnormality of the corticospinal tract (HP:0002492)3.25304672
17Systemic lupus erythematosus (HP:0002725)3.22108986
18Abnormality of macrophages (HP:0004311)3.15510102
19Increased cerebral lipofuscin (HP:0011813)3.13323858
20Focal seizures (HP:0007359)3.12395743
21Atonic seizures (HP:0010819)3.11565356
22Vacuolated lymphocytes (HP:0001922)3.06342674
23Dysmetria (HP:0001310)3.04615337
24Dialeptic seizures (HP:0011146)3.01668659
25Eczematoid dermatitis (HP:0000976)3.01091746
26Colitis (HP:0002583)2.99183242
27Intention tremor (HP:0002080)2.97797835
28Recurrent bacterial skin infections (HP:0005406)2.97524662
29Recurrent abscess formation (HP:0002722)2.97506545
30Absence seizures (HP:0002121)2.88751555
31Pheochromocytoma (HP:0002666)2.87323096
32Orchitis (HP:0100796)2.85905345
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.85407723
34Myositis (HP:0100614)2.85357237
35Cerebral hemorrhage (HP:0001342)2.84224791
36Action tremor (HP:0002345)2.83417047
37Abnormality of monocarboxylic acid metabolism (HP:0010996)2.78195946
38Scanning speech (HP:0002168)2.75014959
39Optic neuritis (HP:0100653)2.73521910
40Retrobulbar optic neuritis (HP:0100654)2.73521910
41Loss of speech (HP:0002371)2.71534884
42Visual hallucinations (HP:0002367)2.70782338
43Spastic gait (HP:0002064)2.69510332
44Spastic paraparesis (HP:0002313)2.68976528
45Conjugated hyperbilirubinemia (HP:0002908)2.67648783
46Epileptic encephalopathy (HP:0200134)2.66452778
47Neuroendocrine neoplasm (HP:0100634)2.66165745
48Malnutrition (HP:0004395)2.64429995
49Generalized tonic-clonic seizures (HP:0002069)2.63782659
50Lower limb hyperreflexia (HP:0002395)2.62956770
51Vasculitis (HP:0002633)2.62034764
52Insidious onset (HP:0003587)2.60782760
53Termporal pattern (HP:0011008)2.60782760
54Spastic tetraparesis (HP:0001285)2.60294422
55Autoimmune hemolytic anemia (HP:0001890)2.57473450
56Mediastinal lymphadenopathy (HP:0100721)2.54883856
57Hyperventilation (HP:0002883)2.54763156
58Parakeratosis (HP:0001036)2.53845074
59Progressive cerebellar ataxia (HP:0002073)2.53566365
60Abnormality of liposaccharide metabolism (HP:0010968)2.53323399
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.53323399
62Abnormality of glycolipid metabolism (HP:0010969)2.53323399
63Retinal dysplasia (HP:0007973)2.50956454
64Progressive inability to walk (HP:0002505)2.50290532
65Recurrent viral infections (HP:0004429)2.50030129
66Akinesia (HP:0002304)2.49484066
67Recurrent gram-negative bacterial infections (HP:0005420)2.46689117
68Xanthomatosis (HP:0000991)2.45664989
69Intrahepatic cholestasis (HP:0001406)2.44942673
70Increased serum ferritin (HP:0003281)2.44420865
71Interstitial pulmonary disease (HP:0006530)2.41790837
72Split foot (HP:0001839)2.38147540
73Ankle clonus (HP:0011448)2.38031141
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36589046
75Gout (HP:0001997)2.35599416
76Hyperglycinemia (HP:0002154)2.35307956
77Glomerulonephritis (HP:0000099)2.35295802
78Chronic diarrhea (HP:0002028)2.34778155
79Cerebral hypomyelination (HP:0006808)2.32978192
80Recurrent bronchitis (HP:0002837)2.31809148
81Hemorrhage of the eye (HP:0011885)2.30413169
82Onion bulb formation (HP:0003383)2.26995012
83Inflammation of the large intestine (HP:0002037)2.23439215
84Fat malabsorption (HP:0002630)2.22750546
85Peripheral hypomyelination (HP:0007182)2.21109830
86Recurrent sinusitis (HP:0011108)2.21047080
87Recurrent skin infections (HP:0001581)2.20818775
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.19283112
89Gingival bleeding (HP:0000225)2.18549048
90Neuronal loss in central nervous system (HP:0002529)2.18111578
91Abnormality of glutamine family amino acid metabolism (HP:0010902)2.17759624
92Axonal loss (HP:0003447)2.17370914
93Pulmonary infiltrates (HP:0002113)2.15253365
94Abnormal eating behavior (HP:0100738)2.15148497
95Abnormality of glycolysis (HP:0004366)2.14138518
96Increased serum pyruvate (HP:0003542)2.14138518
97Polyphagia (HP:0002591)2.13775552
98Clumsiness (HP:0002312)2.12620951
99Gastrointestinal inflammation (HP:0004386)2.12176436
100Dysdiadochokinesis (HP:0002075)2.10640286
101Exocrine pancreatic insufficiency (HP:0001738)2.09872267
102Meningitis (HP:0001287)2.09749478
103Tetraplegia (HP:0002445)2.08660757
104Autoimmune thrombocytopenia (HP:0001973)2.06978461
105Ventricular fibrillation (HP:0001663)2.06809039
106Mutism (HP:0002300)2.06199629
107Delusions (HP:0000746)2.04866486
108Abnormality of iron homeostasis (HP:0011031)2.04549162
109Paraparesis (HP:0002385)2.03916781
110Complement deficiency (HP:0004431)2.02991860
111Petechiae (HP:0000967)2.02825104
112Elevated erythrocyte sedimentation rate (HP:0003565)2.02139456
113Asymmetric septal hypertrophy (HP:0001670)2.02032602
114Basal ganglia calcification (HP:0002135)2.01999569
115Gingivitis (HP:0000230)2.01765381
116Epileptiform EEG discharges (HP:0011182)2.01689668
117Generalized myoclonic seizures (HP:0002123)2.00899087
118Congenital ichthyosiform erythroderma (HP:0007431)2.00697829
119Prolonged neonatal jaundice (HP:0006579)2.00541385
120Autoamputation (HP:0001218)2.00126442
121Truncal ataxia (HP:0002078)2.00010543
122Slow saccadic eye movements (HP:0000514)1.99140107
123EEG with generalized epileptiform discharges (HP:0011198)1.99089658
124Recurrent fungal infections (HP:0002841)1.98875962
125Febrile seizures (HP:0002373)1.98343997
126Encephalitis (HP:0002383)1.96057226
127Irritability (HP:0000737)1.95968753
128Sensory axonal neuropathy (HP:0003390)1.95784360
129Pustule (HP:0200039)1.95683102
130Chronic mucocutaneous candidiasis (HP:0002728)1.95601365
131Recurrent cutaneous fungal infections (HP:0011370)1.95601365
132Anxiety (HP:0000739)1.95416304
133Abnormality of serine family amino acid metabolism (HP:0010894)1.94673589
134Abnormality of glycine metabolism (HP:0010895)1.94673589
135Renal Fanconi syndrome (HP:0001994)1.94442144
136J-shaped sella turcica (HP:0002680)1.94210979
137Abnormal delayed hypersensitivity skin test (HP:0002963)1.93397414
138Purpura (HP:0000979)1.93151120
139Clonus (HP:0002169)1.92216070
140Methylmalonic aciduria (HP:0012120)1.91679182
141Cardiomegaly (HP:0001640)1.91401405
142Hypsarrhythmia (HP:0002521)1.90819652
143Chronic obstructive pulmonary disease (HP:0006510)1.90644514
144Obstructive lung disease (HP:0006536)1.90644514
145Confusion (HP:0001289)1.90299879
146Thickened helices (HP:0000391)1.89938514
147Steatorrhea (HP:0002570)1.89889960
148Rigidity (HP:0002063)1.89609069
149CNS hypomyelination (HP:0003429)1.89177814
150Athetosis (HP:0002305)1.88952797
151Flat acetabular roof (HP:0003180)1.88739994
152Ileus (HP:0002595)1.87986078
153Deep venous thrombosis (HP:0002625)1.87084362
154Gastrointestinal infarctions (HP:0005244)1.86719964
155Right ventricular cardiomyopathy (HP:0011663)1.85878408
156Progressive neurologic deterioration (HP:0002344)1.85663758
157Abnormality of complement system (HP:0005339)1.84814667
158Broad-based gait (HP:0002136)1.84177721
159Abnormality of transition element cation homeostasis (HP:0011030)1.83008543
160Impaired social interactions (HP:0000735)1.82619132
161Abnormal social behavior (HP:0012433)1.82619132
162Periodontitis (HP:0000704)1.82373788
163Methylmalonic acidemia (HP:0002912)1.81847688
164Brittle hair (HP:0002299)1.81365969
165Increased circulating renin level (HP:0000848)1.80562654
166Septate vagina (HP:0001153)1.80468337
167Morphological abnormality of the pyramidal tract (HP:0002062)1.79123392
168Abnormality of binocular vision (HP:0011514)1.78971899
169Diplopia (HP:0000651)1.78971899
170Myoclonus (HP:0001336)1.78538880
171Segmental peripheral demyelination/remyelination (HP:0003481)1.77925549
172Anteriorly placed anus (HP:0001545)1.76790340
173Nasal polyposis (HP:0100582)1.74542852
174Poor suck (HP:0002033)1.74456068
175Exercise-induced myalgia (HP:0003738)1.73845750
176Osteomyelitis (HP:0002754)1.73239848
177Abnormality of the lumbar spine (HP:0100712)1.73128056
178Tetraparesis (HP:0002273)1.71059330
179Hemoptysis (HP:0002105)1.70768590
180Hyperactive renin-angiotensin system (HP:0000841)1.70661277
181Disinhibition (HP:0000734)1.70389227
182Glucose intolerance (HP:0000833)1.69441903
183Gastrointestinal stroma tumor (HP:0100723)1.69427972
184Abnormality of T cell number (HP:0011839)1.68886437
185Amyloidosis (HP:0011034)1.67971044
186Keratoconjunctivitis sicca (HP:0001097)1.67968823
187Abnormality of the periventricular white matter (HP:0002518)1.66546540
188Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66333604
189Abnormality of the pleura (HP:0002103)1.65808383
190Abnormality of proline metabolism (HP:0010907)1.65667994
191Hydroxyprolinuria (HP:0003080)1.65667994
192Abnormality of the pericardium (HP:0001697)1.65544362
193Abnormality of the nasal mucosa (HP:0000433)1.65374609

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.14091543
2OXSR13.39998534
3PNCK3.09717106
4ERN12.93867810
5EPHA22.81891076
6TYK22.63803938
7BLK2.52324495
8LMTK22.48853001
9NTRK32.32114352
10MAP3K92.31901110
11EPHA42.24732305
12TESK22.13575886
13ARAF2.08880581
14NTRK12.03594443
15CDK192.02970565
16TBK11.98352774
17MAP2K31.97011632
18MARK11.93743762
19MAPKAPK51.93459364
20WNK41.89954033
21SCYL21.88134752
22EPHB11.78656585
23CAMKK21.77667990
24NME21.77316256
25MATK1.76660423
26FRK1.72554935
27TAOK11.72147661
28MAP3K141.70376268
29CAMK2B1.63895878
30MAP3K31.63364845
31WNK11.60969849
32IRAK41.58398040
33MAP3K41.58104374
34MAP3K121.55208098
35IKBKE1.54401036
36KSR21.53218871
37DAPK21.51192027
38RIPK41.48341573
39NME11.41937629
40BCR1.41635753
41PAK61.41491124
42CAMK2G1.40555893
43MAP2K41.40473812
44MAP3K61.39954717
45IRAK11.36776750
46MET1.36434125
47JAK11.34455263
48TRIB31.33887987
49CAMK2D1.32700200
50MAP2K71.32101103
51SGK2231.31859818
52SGK4941.31859818
53MAP3K21.31416677
54PKN11.30835702
55FGFR21.28467308
56RIPK11.28139204
57CSF1R1.25890459
58ZAP701.24455629
59FGR1.23422625
60EPHA31.23135300
61CDK51.15038978
62MAP4K11.14427664
63MAP3K51.14305581
64CSK1.14125849
65AKT31.12941582
66TAOK21.11794821
67MAP3K131.11400564
68CAMK2A1.11329217
69IKBKB1.08079502
70CSNK1G21.07135490
71PRKCG1.06410352
72MINK11.06010764
73FGFR31.05292101
74ACVR1B1.05177991
75CSNK1G31.05128883
76MAP2K61.02983748
77BTK1.00995441
78MAP3K110.97595698
79CASK0.97561540
80TGFBR20.95470658
81FES0.94382238
82PDPK10.93468869
83FER0.92208138
84GRK50.91896105
85MAPK110.91790773
86MAP2K20.91519551
87NTRK20.90958277
88TNIK0.88610461
89LIMK10.88500676
90PRKCE0.88054647
91ROCK20.87752151
92CSNK1A1L0.87423859
93LATS10.85382260
94PRKCQ0.83236220
95CAMKK10.82359040
96SYK0.81988770
97TRPM70.81921303
98NEK60.80917809
99GRK60.79727079
100CDK140.79429471
101SIK10.79170072
102PLK20.78625562
103JAK20.78399758
104PRKCH0.78292353
105PINK10.78089688
106PIK3CG0.73864704
107ERBB30.73303206
108FGFR40.72895222
109PRKD20.72653364
110JAK30.72463290
111STK380.72142171
112CDK150.71534670
113MARK20.68395019
114BMPR20.68171724
115PAK30.68105093
116MAP2K10.67932688
117GRK70.67689876
118BUB10.67214239
119CDK180.66610576
120STK110.66004752
121LYN0.65969954
122CSNK1G10.65790489
123IRAK20.63712017
124PRKG20.63353170
125PDK10.63110207
126KIT0.62329600
127CDK11A0.61723264
128PRPF4B0.61607200
129MST40.61143233
130PTK2B0.59831899
131ERBB40.59745417
132PTK20.59341573
133IRAK30.58107978
134LCK0.57747502
135CDC42BPA0.57549237
136CSNK1A10.57425076
137MST1R0.56954280
138MARK30.56187368
139HCK0.55130874
140RET0.54973505
141UHMK10.53787525
142PRKAA20.53654622
143PDK40.53107463
144PDK30.53107463
145TXK0.52729131
146ICK0.52488836
147PIM20.50838271
148DYRK1A0.49943205
149SIK30.48745864
150PRKCZ0.48110464
151MAP3K10.46785444
152CHUK0.44984686
153INSRR0.44756859
154BRAF0.43418055
155WNK30.42812154
156TAOK30.42413203
157FYN0.42084371
158CCNB10.42007958
159TYRO30.41172572
160MAPK130.40744533
161SIK20.40170334
162PRKACA0.40084252
163PRKCA0.39849777
164PDK20.39647774
165MAPK120.39158028
166YES10.36131754
167NEK90.35879478
168PDGFRB0.35122654
169OBSCN0.33740364
170PIK3CA0.33672422
171TNK20.30692215

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.88404399
2Asthma_Homo sapiens_hsa053102.67970350
3Nitrogen metabolism_Homo sapiens_hsa009102.65545805
4Other glycan degradation_Homo sapiens_hsa005112.59856455
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.53888399
6Allograft rejection_Homo sapiens_hsa053302.51444375
7Steroid biosynthesis_Homo sapiens_hsa001002.48425114
8Synaptic vesicle cycle_Homo sapiens_hsa047212.44349412
9Staphylococcus aureus infection_Homo sapiens_hsa051502.42873966
10Nicotine addiction_Homo sapiens_hsa050332.30086188
11Vitamin B6 metabolism_Homo sapiens_hsa007502.29541212
12Collecting duct acid secretion_Homo sapiens_hsa049662.28197945
13Fatty acid elongation_Homo sapiens_hsa000622.25067422
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.23630781
15Autoimmune thyroid disease_Homo sapiens_hsa053202.22613112
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22330302
17Graft-versus-host disease_Homo sapiens_hsa053322.17635522
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14778619
19Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11686125
20Leishmaniasis_Homo sapiens_hsa051402.11503207
21GABAergic synapse_Homo sapiens_hsa047272.08001886
22Butanoate metabolism_Homo sapiens_hsa006501.92296389
23Type I diabetes mellitus_Homo sapiens_hsa049401.83347332
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74786811
25Osteoclast differentiation_Homo sapiens_hsa043801.70135439
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68736311
27Glutamatergic synapse_Homo sapiens_hsa047241.67506849
28Oxidative phosphorylation_Homo sapiens_hsa001901.67321366
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64192795
30Tuberculosis_Homo sapiens_hsa051521.59708229
31Regulation of autophagy_Homo sapiens_hsa041401.59559700
32Influenza A_Homo sapiens_hsa051641.57740562
33B cell receptor signaling pathway_Homo sapiens_hsa046621.55096953
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52903086
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.50240264
36Hepatitis C_Homo sapiens_hsa051601.48887362
37Morphine addiction_Homo sapiens_hsa050321.44591333
38Histidine metabolism_Homo sapiens_hsa003401.43789408
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43099163
40Vibrio cholerae infection_Homo sapiens_hsa051101.42847515
41Ether lipid metabolism_Homo sapiens_hsa005651.42782677
42TNF signaling pathway_Homo sapiens_hsa046681.42690900
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41325987
44Toxoplasmosis_Homo sapiens_hsa051451.40814786
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37173449
46Arginine biosynthesis_Homo sapiens_hsa002201.36664690
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.30538454
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29798306
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.29335047
50Pertussis_Homo sapiens_hsa051331.28377638
51Long-term potentiation_Homo sapiens_hsa047201.27286002
52Circadian entrainment_Homo sapiens_hsa047131.26266939
53Long-term depression_Homo sapiens_hsa047301.23806551
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23582378
55Serotonergic synapse_Homo sapiens_hsa047261.20509898
56NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19654826
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17977517
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17155200
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16183393
60Sulfur metabolism_Homo sapiens_hsa009201.15702963
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13521372
62Sphingolipid metabolism_Homo sapiens_hsa006001.12362836
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12333164
64Taste transduction_Homo sapiens_hsa047421.11292491
65Legionellosis_Homo sapiens_hsa051341.10334653
66Amphetamine addiction_Homo sapiens_hsa050311.07861562
67Measles_Homo sapiens_hsa051621.07793394
68Viral myocarditis_Homo sapiens_hsa054161.06839824
69Renin-angiotensin system_Homo sapiens_hsa046141.06794867
70Salivary secretion_Homo sapiens_hsa049701.06630354
71Antigen processing and presentation_Homo sapiens_hsa046121.06414316
72Alzheimers disease_Homo sapiens_hsa050101.06352173
73Dopaminergic synapse_Homo sapiens_hsa047281.05500188
74Cyanoamino acid metabolism_Homo sapiens_hsa004601.04871574
75African trypanosomiasis_Homo sapiens_hsa051431.04774956
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03194649
77Lysosome_Homo sapiens_hsa041421.02776855
78Peroxisome_Homo sapiens_hsa041461.02433353
79Gastric acid secretion_Homo sapiens_hsa049711.01538967
80Parkinsons disease_Homo sapiens_hsa050121.01367257
81Herpes simplex infection_Homo sapiens_hsa051681.00922511
82Drug metabolism - other enzymes_Homo sapiens_hsa009831.00770843
83Folate biosynthesis_Homo sapiens_hsa007900.99410364
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98355339
85Phagosome_Homo sapiens_hsa041450.96652246
86Hematopoietic cell lineage_Homo sapiens_hsa046400.95471469
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.95101828
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.94454020
89Insulin secretion_Homo sapiens_hsa049110.93451762
90Fatty acid metabolism_Homo sapiens_hsa012120.93256917
91Chemical carcinogenesis_Homo sapiens_hsa052040.91873578
92Pancreatic secretion_Homo sapiens_hsa049720.88175405
93Propanoate metabolism_Homo sapiens_hsa006400.86102898
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85968724
95Cocaine addiction_Homo sapiens_hsa050300.84797367
96Bile secretion_Homo sapiens_hsa049760.83158991
97Starch and sucrose metabolism_Homo sapiens_hsa005000.82838044
98Olfactory transduction_Homo sapiens_hsa047400.82309104
99Galactose metabolism_Homo sapiens_hsa000520.81379080
100Acute myeloid leukemia_Homo sapiens_hsa052210.80268990
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77764972
102Salmonella infection_Homo sapiens_hsa051320.76955693
103beta-Alanine metabolism_Homo sapiens_hsa004100.75276488
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74830578
105Hepatitis B_Homo sapiens_hsa051610.74742225
106Cholinergic synapse_Homo sapiens_hsa047250.73352197
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73286516
108Vitamin digestion and absorption_Homo sapiens_hsa049770.72651731
109Pancreatic cancer_Homo sapiens_hsa052120.71274414
110Insulin resistance_Homo sapiens_hsa049310.71267318
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.71242921
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71087431
113Arginine and proline metabolism_Homo sapiens_hsa003300.70651388
114ABC transporters_Homo sapiens_hsa020100.70124745
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70065115
116Prolactin signaling pathway_Homo sapiens_hsa049170.69678661
117Apoptosis_Homo sapiens_hsa042100.69280175
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68811970
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68508481
120T cell receptor signaling pathway_Homo sapiens_hsa046600.67924006
121Malaria_Homo sapiens_hsa051440.67467635
122Chemokine signaling pathway_Homo sapiens_hsa040620.66989909
123Protein export_Homo sapiens_hsa030600.66642799
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66596487
125Renin secretion_Homo sapiens_hsa049240.66398697
126Rheumatoid arthritis_Homo sapiens_hsa053230.66278150
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.65637458
128Fructose and mannose metabolism_Homo sapiens_hsa000510.64459485
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.64314984
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64131098
131Calcium signaling pathway_Homo sapiens_hsa040200.63331411
132Sulfur relay system_Homo sapiens_hsa041220.62478728
133Caffeine metabolism_Homo sapiens_hsa002320.61953624
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61687189
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61182156
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60644810
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.60473251
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59100359
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58272653
140Linoleic acid metabolism_Homo sapiens_hsa005910.57877882
141Cardiac muscle contraction_Homo sapiens_hsa042600.57398070
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57169727
143Mineral absorption_Homo sapiens_hsa049780.57041331
144Glycerolipid metabolism_Homo sapiens_hsa005610.56309421
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56295217
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55791438
147Renal cell carcinoma_Homo sapiens_hsa052110.55762841
148Platelet activation_Homo sapiens_hsa046110.55560367
149Fatty acid degradation_Homo sapiens_hsa000710.55538630
150Systemic lupus erythematosus_Homo sapiens_hsa053220.55382773
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.55297253
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54188796
153Complement and coagulation cascades_Homo sapiens_hsa046100.53844114
154Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53840775
155Tryptophan metabolism_Homo sapiens_hsa003800.53536804
156Endocytosis_Homo sapiens_hsa041440.52972648
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52961337
158Prion diseases_Homo sapiens_hsa050200.52021471
159Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51611214
160Fatty acid biosynthesis_Homo sapiens_hsa000610.51567665
161Non-small cell lung cancer_Homo sapiens_hsa052230.49923480
162Phenylalanine metabolism_Homo sapiens_hsa003600.49693206
163Oxytocin signaling pathway_Homo sapiens_hsa049210.48977864
164Proteasome_Homo sapiens_hsa030500.48325456
165Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46911101
166Pyruvate metabolism_Homo sapiens_hsa006200.46304193
167Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45825993
168Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45733573
169VEGF signaling pathway_Homo sapiens_hsa043700.45351395
170Metabolic pathways_Homo sapiens_hsa011000.45023340
171Gap junction_Homo sapiens_hsa045400.44931766
172Inositol phosphate metabolism_Homo sapiens_hsa005620.44765723
173Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44370062
174Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44178910
175Huntingtons disease_Homo sapiens_hsa050160.44045156
176PPAR signaling pathway_Homo sapiens_hsa033200.43582190
177N-Glycan biosynthesis_Homo sapiens_hsa005100.42772929
178Primary immunodeficiency_Homo sapiens_hsa053400.42500687
179AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40209109
180Fat digestion and absorption_Homo sapiens_hsa049750.40068768

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