TMEM64

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.25739622
2regulation of centriole replication (GO:0046599)4.98111968
3valine metabolic process (GO:0006573)4.83569247
4intestinal epithelial cell development (GO:0060576)4.79227007
5lysine metabolic process (GO:0006553)4.47031970
6lysine catabolic process (GO:0006554)4.47031970
7cellular zinc ion homeostasis (GO:0006882)4.31408502
8vagina development (GO:0060068)4.18866077
9cysteine metabolic process (GO:0006534)4.17560070
10prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.05104861
11homocysteine metabolic process (GO:0050667)4.02646334
12positive regulation of fatty acid beta-oxidation (GO:0032000)3.90034206
13paraxial mesoderm development (GO:0048339)3.84124571
14sulfur amino acid catabolic process (GO:0000098)3.81541922
15drug transmembrane transport (GO:0006855)3.81517315
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.79294949
17nuclear pore complex assembly (GO:0051292)3.71821892
18regulation of fatty acid beta-oxidation (GO:0031998)3.70068835
192-oxoglutarate metabolic process (GO:0006103)3.65241401
20regulation of cholesterol homeostasis (GO:2000188)3.62716345
21zinc ion transmembrane transport (GO:0071577)3.57778406
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.54401261
23L-phenylalanine metabolic process (GO:0006558)3.54401261
24carnitine shuttle (GO:0006853)3.52758949
25serine family amino acid catabolic process (GO:0009071)3.50751344
26maternal placenta development (GO:0001893)3.48968577
27amino-acid betaine transport (GO:0015838)3.48067154
28carnitine transport (GO:0015879)3.48067154
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.46677162
30L-phenylalanine catabolic process (GO:0006559)3.46677162
31amino-acid betaine metabolic process (GO:0006577)3.46421759
32regulation of cell proliferation involved in kidney development (GO:1901722)3.45696217
33positive regulation of keratinocyte differentiation (GO:0045618)3.43039726
34positive regulation of catenin import into nucleus (GO:0035413)3.42187050
35alpha-linolenic acid metabolic process (GO:0036109)3.41389029
36fatty acid transmembrane transport (GO:1902001)3.40377296
37regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.39429511
38cardiac right ventricle morphogenesis (GO:0003215)3.39294333
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.35922936
40ear development (GO:0043583)3.34883105
41glyoxylate metabolic process (GO:0046487)3.34223467
42cellular modified amino acid catabolic process (GO:0042219)3.29182383
434-hydroxyproline metabolic process (GO:0019471)3.29081545
44quaternary ammonium group transport (GO:0015697)3.25801415
45embryonic camera-type eye morphogenesis (GO:0048596)3.22025767
46carnitine transmembrane transport (GO:1902603)3.21403955
47uterus development (GO:0060065)3.20331083
48branching involved in salivary gland morphogenesis (GO:0060445)3.19293672
49branched-chain amino acid metabolic process (GO:0009081)3.17589559
50protein carboxylation (GO:0018214)3.17055694
51peptidyl-glutamic acid carboxylation (GO:0017187)3.17055694
52protein complex localization (GO:0031503)3.16013732
53striated muscle atrophy (GO:0014891)3.14624805
54female genitalia development (GO:0030540)3.14166665
55nuclear pore organization (GO:0006999)3.13150604
56kynurenine metabolic process (GO:0070189)3.12679833
57aspartate family amino acid catabolic process (GO:0009068)3.11853985
58positive regulation of fatty acid oxidation (GO:0046321)3.11434438
59tricarboxylic acid metabolic process (GO:0072350)3.11235152
60regulation of establishment of cell polarity (GO:2000114)3.08918541
61short-chain fatty acid metabolic process (GO:0046459)3.08197895
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08177479
63aromatic amino acid family catabolic process (GO:0009074)3.08117625
64urate metabolic process (GO:0046415)3.07448409
65ER overload response (GO:0006983)3.05456684
66positive regulation of hormone metabolic process (GO:0032352)3.05167640
67regulation of skeletal muscle contraction (GO:0014819)3.04999998
68plasma membrane repair (GO:0001778)3.03582035
69skeletal muscle adaptation (GO:0043501)3.01315958
70actin-myosin filament sliding (GO:0033275)3.00503333
71muscle filament sliding (GO:0030049)3.00503333
72embryonic eye morphogenesis (GO:0048048)3.00429896
73branching involved in mammary gland duct morphogenesis (GO:0060444)2.99060207
74TOR signaling (GO:0031929)2.98269130
75regulation of establishment or maintenance of cell polarity (GO:0032878)2.98148840
76hepatocyte apoptotic process (GO:0097284)2.97620321
77regulation of centrosome duplication (GO:0010824)2.97578619
78muscle atrophy (GO:0014889)2.95713974
79mitotic sister chromatid cohesion (GO:0007064)2.93305779
80fatty acid beta-oxidation (GO:0006635)2.92596669
81drug transport (GO:0015893)2.92198025
82mesonephros development (GO:0001823)2.91912618
83ectodermal placode formation (GO:0060788)2.90866781
84desmosome organization (GO:0002934)2.90207061
85mammary gland epithelial cell proliferation (GO:0033598)2.89765663
86embryonic process involved in female pregnancy (GO:0060136)2.87749271
87epithelial cell maturation (GO:0002070)2.87038906
88protein retention in ER lumen (GO:0006621)2.86038744
89positive regulation of insulin receptor signaling pathway (GO:0046628)2.85265688
90negative regulation of fatty acid biosynthetic process (GO:0045717)2.84731613
91peptidyl-threonine dephosphorylation (GO:0035970)2.84440117
92carnitine metabolic process (GO:0009437)2.82427611
93dicarboxylic acid biosynthetic process (GO:0043650)2.80614527
94response to mercury ion (GO:0046689)2.79095886
95oxaloacetate metabolic process (GO:0006107)2.78335819
96fatty acid oxidation (GO:0019395)2.78306567
97positive regulation of translational initiation (GO:0045948)2.78096241
98peptidyl-arginine omega-N-methylation (GO:0035247)2.77146890
99branched-chain amino acid catabolic process (GO:0009083)2.77027819
100cellular protein complex localization (GO:0034629)2.76850421
101regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.76788437
102negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.76741868
103branching involved in prostate gland morphogenesis (GO:0060442)2.75990675
104regulation of fatty acid oxidation (GO:0046320)2.74576361
105regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74483995
106regulation of protein activation cascade (GO:2000257)2.74451996
107tryptophan catabolic process (GO:0006569)2.74173618
108indole-containing compound catabolic process (GO:0042436)2.74173618
109indolalkylamine catabolic process (GO:0046218)2.74173618
110positive regulation of epidermal cell differentiation (GO:0045606)2.73995323
111cellular amino acid catabolic process (GO:0009063)2.73832118
112serine family amino acid metabolic process (GO:0009069)2.73571014
113tryptophan metabolic process (GO:0006568)2.72821825
114histone arginine methylation (GO:0034969)2.72779618
115glutamate metabolic process (GO:0006536)2.71879512
116negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.71868957
117lipid oxidation (GO:0034440)2.69869787
118negative regulation of DNA repair (GO:0045738)2.69593449
119hormone catabolic process (GO:0042447)2.69549388
120COPII vesicle coating (GO:0048208)2.68584518
121alpha-amino acid catabolic process (GO:1901606)2.67468287
122epoxygenase P450 pathway (GO:0019373)2.67049181
123regulation of complement activation (GO:0030449)2.66767199
124negative regulation of fibrinolysis (GO:0051918)2.66158835
125exocrine pancreas development (GO:0031017)2.65509099
126prostate gland growth (GO:0060736)2.65395373
127macroautophagy (GO:0016236)2.65376165
128regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64643577
129tight junction assembly (GO:0070830)2.64316782
130skeletal muscle fiber development (GO:0048741)2.64271656
131response to iron ion (GO:0010039)2.63994391
132regulation of histone H3-K27 methylation (GO:0061085)2.63975516
133anterior/posterior axis specification, embryo (GO:0008595)2.63841181
134complement activation, alternative pathway (GO:0006957)2.62793122
135protein localization to endosome (GO:0036010)2.62597288
136regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.62139298
137positive regulation of cellular response to insulin stimulus (GO:1900078)2.62110400
138ethanol oxidation (GO:0006069)2.62027367
139activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.61290330
140L-alpha-amino acid transmembrane transport (GO:1902475)2.60554889
141actin-mediated cell contraction (GO:0070252)2.60449530
142negative regulation of lipid transport (GO:0032369)2.60285312
143biotin metabolic process (GO:0006768)2.59976763
144adherens junction assembly (GO:0034333)2.58438038
145negative regulation of cholesterol transport (GO:0032375)2.57974279
146negative regulation of sterol transport (GO:0032372)2.57974279
147bile acid biosynthetic process (GO:0006699)2.57625274
148regulation of centrosome cycle (GO:0046605)2.57573866
149peptidyl-arginine methylation (GO:0018216)2.57475637
150peptidyl-arginine N-methylation (GO:0035246)2.57475637
151response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.57077342
152purine ribonucleotide transport (GO:0015868)2.56332762
153positive regulation of glycogen biosynthetic process (GO:0045725)2.56223814
154positive regulation of histone deacetylation (GO:0031065)2.55716673
155cell migration involved in sprouting angiogenesis (GO:0002042)2.55237507
156phosphate ion transmembrane transport (GO:0035435)2.54895434
157fatty acid catabolic process (GO:0009062)2.54059409
158hypotonic response (GO:0006971)2.52977428
159glycine metabolic process (GO:0006544)2.52209404
160pre-miRNA processing (GO:0031054)2.50586497
161triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.49850059
162apoptotic cell clearance (GO:0043277)2.49804449
163zinc ion homeostasis (GO:0055069)2.49768937
164regulation of translational fidelity (GO:0006450)2.49277734
165regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.48759207
166phosphate ion transport (GO:0006817)2.48607039
167lung-associated mesenchyme development (GO:0060484)2.48416259
168protein hydroxylation (GO:0018126)2.48277082
169Golgi transport vesicle coating (GO:0048200)2.48067550
170COPI coating of Golgi vesicle (GO:0048205)2.48067550
171acetyl-CoA metabolic process (GO:0006084)2.47570832
172regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47093496
173zinc ion transport (GO:0006829)2.47000603
174regulation of sister chromatid cohesion (GO:0007063)2.45876932
175nucleotide-sugar biosynthetic process (GO:0009226)2.45108742
176embryonic foregut morphogenesis (GO:0048617)2.43395668
177gap junction assembly (GO:0016264)2.40133935
178mammary gland alveolus development (GO:0060749)2.39563377
179positive regulation of macroautophagy (GO:0016239)2.38708618
180negative regulation of focal adhesion assembly (GO:0051895)2.38528384
181negative regulation of cell junction assembly (GO:1901889)2.38528384
182negative regulation of adherens junction organization (GO:1903392)2.38528384
183positive regulation of nitric-oxide synthase activity (GO:0051000)2.38035339
184apical protein localization (GO:0045176)2.37851331
185negative regulation of protein localization to plasma membrane (GO:1903077)2.36968978
186proline biosynthetic process (GO:0006561)2.35995057
187cellular response to estrogen stimulus (GO:0071391)2.34497920
188adenine nucleotide transport (GO:0051503)2.33262388
189asymmetric protein localization (GO:0008105)2.31278846
190regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.31031718
191establishment of apical/basal cell polarity (GO:0035089)2.30610836
192pore complex assembly (GO:0046931)2.30356241
193regulation of transforming growth factor beta2 production (GO:0032909)2.29170512
194keratinocyte development (GO:0003334)2.28571400
195DNA unwinding involved in DNA replication (GO:0006268)2.28259374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.56662063
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.41874380
3E2F7_22180533_ChIP-Seq_HELA_Human4.28367815
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.17434084
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.93428785
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.61480828
7CLOCK_20551151_ChIP-Seq_293T_Human3.55757701
8ZNF263_19887448_ChIP-Seq_K562_Human3.45005995
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22450163
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.02035300
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.95962875
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.65228880
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63952422
14* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.63086246
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.54360971
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.53852300
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.53821432
18* ESR1_21235772_ChIP-Seq_MCF-7_Human2.45821443
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.28345438
20AHR_22903824_ChIP-Seq_MCF-7_Human2.27807521
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27379362
22* MYC_18555785_ChIP-Seq_MESCs_Mouse2.26255963
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.16667547
24FOXM1_26456572_ChIP-Seq_MCF-7_Human2.13881926
25AR_21909140_ChIP-Seq_LNCAP_Human2.06733930
26* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.04098719
27TP63_17297297_ChIP-ChIP_HaCaT_Human2.01101725
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00200993
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87440726
30ER_23166858_ChIP-Seq_MCF-7_Human1.86385668
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.85089126
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82211861
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.81003958
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.80176855
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78128569
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77251406
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77251406
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77251406
39PKCTHETA_26484144_Chip-Seq_BREAST_Human1.77185189
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.76436594
41GATA1_22025678_ChIP-Seq_K562_Human1.68728382
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68085290
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68031630
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66919257
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63620596
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62183702
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58303129
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54293727
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53863711
50* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53317237
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52927370
52ATF3_27146783_Chip-Seq_COLON_Human1.52609483
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48216216
54RACK7_27058665_Chip-Seq_MCF-7_Human1.46375739
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46133044
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45651562
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44195070
58* TBX20_22328084_ChIP-Seq_HEART_Mouse1.43585578
59* TBX20_22080862_ChIP-Seq_HEART_Mouse1.43585578
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41612429
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41077470
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.40854163
63DCP1A_22483619_ChIP-Seq_HELA_Human1.39472832
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.38882592
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38215417
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36059333
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35970368
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.35475598
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35473691
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.34449090
71* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32261948
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31371609
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.31325243
74FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.31275964
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31115800
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.30300562
77* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29815920
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29782608
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28493302
80TCF7_22412390_ChIP-Seq_EML_Mouse1.26894082
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26851909
82MYC_22102868_ChIP-Seq_BL_Human1.25992271
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23667179
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22808477
85KDM2B_26808549_Chip-Seq_DND41_Human1.21935506
86ELF5_23300383_ChIP-Seq_T47D_Human1.19664563
87ELK1_19687146_ChIP-ChIP_HELA_Human1.18804381
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18795836
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.18333164
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17902864
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.17619260
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17511434
93* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16968912
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16532303
95TFEB_21752829_ChIP-Seq_HELA_Human1.15207282
96SOX17_20123909_ChIP-Seq_XEN_Mouse1.15193993
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14841674
98CREB1_26743006_Chip-Seq_LNCaP_Human1.14601263
99GATA6_25053715_ChIP-Seq_YYC3_Human1.14508679
100GATA4_25053715_ChIP-Seq_YYC3_Human1.13792200
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13417252
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13318630
103* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12993540
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11042055
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.10219722
106FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10181372
107TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08863234
108* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08196150
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07582397
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07349441
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.07072186
112* GATA3_24758297_ChIP-Seq_MCF-7_Human1.05897618
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05701201
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.05109580
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04554095
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04154251
117CHD1_26751641_Chip-Seq_LNCaP_Human1.03889595
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03495465
119TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01885906
120NCOR1_26117541_ChIP-Seq_K562_Human1.01651162
121* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01195559
122TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01153907
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00576211
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00560034
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00511693
126SOX2_16153702_ChIP-ChIP_HESCs_Human1.00486979
127* CJUN_26792858_Chip-Seq_BT549_Human1.00141166
128STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00096464
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99913349
130YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98955494
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98210243
132CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97955282
133DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96781605
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96627449
135* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96004755
136GATA1_19941826_ChIP-Seq_K562_Human0.95889909
137EWS_26573619_Chip-Seq_HEK293_Human0.95795932
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95356952
139HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93559340
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93124468
141BRD4_25478319_ChIP-Seq_HGPS_Human0.92074316
142ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91605034
143KDM2B_26808549_Chip-Seq_K562_Human0.91493106
144MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90925124
145NANOG_21062744_ChIP-ChIP_HESCs_Human0.90581586
146TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90319264
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.89821279
148LXR_22292898_ChIP-Seq_THP-1_Human0.89574944
149TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89035099
150CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88995108
151DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88510351
152MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87234977
153NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87093566
154SOX2_20726797_ChIP-Seq_SW620_Human0.87063495
155ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87029141
156SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86067924
157SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86067924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.25755049
2MP0009780_abnormal_chondrocyte_physiolo4.11783139
3MP0003705_abnormal_hypodermis_morpholog3.61994911
4MP0003941_abnormal_skin_development3.40441706
5MP0005360_urolithiasis3.19975538
6MP0008438_abnormal_cutaneous_collagen3.17208650
7MP0003300_gastrointestinal_ulcer2.85965317
8MP0000383_abnormal_hair_follicle2.85208253
9MP0005365_abnormal_bile_salt2.81778406
10MP0005085_abnormal_gallbladder_physiolo2.76851963
11MP0010234_abnormal_vibrissa_follicle2.65069552
12MP0000462_abnormal_digestive_system2.55074993
13MP0003252_abnormal_bile_duct2.54204944
14MP0005275_abnormal_skin_tensile2.43927265
15MP0008057_abnormal_DNA_replication2.38642325
16MP0005332_abnormal_amino_acid1.97101853
17MP0003806_abnormal_nucleotide_metabolis1.97086554
18MP0004145_abnormal_muscle_electrophysio1.95988889
19MP0000747_muscle_weakness1.95121742
20MP0009672_abnormal_birth_weight1.92626051
21MP0000751_myopathy1.88769949
22MP0004957_abnormal_blastocyst_morpholog1.82789885
23MP0000749_muscle_degeneration1.81801690
24MP0000427_abnormal_hair_cycle1.81052710
25MP0008875_abnormal_xenobiotic_pharmacok1.80080650
26MP0005503_abnormal_tendon_morphology1.77777539
27MP0003942_abnormal_urinary_system1.75494357
28MP0000579_abnormal_nail_morphology1.69985175
29MP0000733_abnormal_muscle_development1.69162447
30MP0002269_muscular_atrophy1.67752567
31MP0010329_abnormal_lipoprotein_level1.65163732
32MP0000537_abnormal_urethra_morphology1.64552813
33MP0002009_preneoplasia1.63460349
34MP0005257_abnormal_intraocular_pressure1.62018048
35MP0003195_calcinosis1.61502444
36MP0003878_abnormal_ear_physiology1.60800388
37MP0005377_hearing/vestibular/ear_phenot1.60800388
38MP0003890_abnormal_embryonic-extraembry1.60256227
39MP0009384_cardiac_valve_regurgitation1.59410804
40MP0010352_gastrointestinal_tract_polyps1.58842911
41MP0004130_abnormal_muscle_cell1.58064725
42MP0002108_abnormal_muscle_morphology1.54863882
43MP0005501_abnormal_skin_physiology1.52542163
44MP0002837_dystrophic_cardiac_calcinosis1.52253338
45MP0000750_abnormal_muscle_regeneration1.52194444
46MP0001666_abnormal_nutrient_absorption1.50526649
47MP0004019_abnormal_vitamin_homeostasis1.50395084
48MP0005248_abnormal_Harderian_gland1.49199791
49MP0005408_hypopigmentation1.48745629
50MP0004087_abnormal_muscle_fiber1.48535983
51MP0002736_abnormal_nociception_after1.43654865
52MP0002697_abnormal_eye_size1.42969997
53MP0003937_abnormal_limbs/digits/tail_de1.42344287
54MP0009703_decreased_birth_body1.40710515
55MP0005083_abnormal_biliary_tract1.38604244
56MP0000627_abnormal_mammary_gland1.38127979
57MP0003566_abnormal_cell_adhesion1.37010892
58MP0009643_abnormal_urine_homeostasis1.36980947
59MP0003693_abnormal_embryo_hatching1.36555173
60MP0004036_abnormal_muscle_relaxation1.36470252
61MP0002138_abnormal_hepatobiliary_system1.36294368
62MP0009697_abnormal_copulation1.35509416
63MP0004084_abnormal_cardiac_muscle1.34071321
64MP0004272_abnormal_basement_membrane1.33782048
65MP0002896_abnormal_bone_mineralization1.33413318
66MP0002098_abnormal_vibrissa_morphology1.33233430
67MP0000609_abnormal_liver_physiology1.32634975
68MP0002160_abnormal_reproductive_system1.29964891
69MP0005319_abnormal_enzyme/_coenzyme1.29871732
70MP0001697_abnormal_embryo_size1.28557503
71MP0005076_abnormal_cell_differentiation1.27759129
72MP0010307_abnormal_tumor_latency1.27241859
73MP0002877_abnormal_melanocyte_morpholog1.27179022
74MP0002088_abnormal_embryonic_growth/wei1.26148276
75MP0010030_abnormal_orbit_morphology1.26017397
76MP0005380_embryogenesis_phenotype1.25365745
77MP0001672_abnormal_embryogenesis/_devel1.25365745
78MP0004043_abnormal_pH_regulation1.25330440
79MP0002089_abnormal_postnatal_growth/wei1.24284942
80MP0003984_embryonic_growth_retardation1.23903642
81MP0001756_abnormal_urination1.22774673
82MP0002106_abnormal_muscle_physiology1.21613963
83MP0002166_altered_tumor_susceptibility1.21345783
84MP0010094_abnormal_chromosome_stability1.21312000
85MP0000377_abnormal_hair_follicle1.20894691
86MP0005023_abnormal_wound_healing1.20827110
87MP0003111_abnormal_nucleus_morphology1.20081167
88MP0001881_abnormal_mammary_gland1.19556148
89MP0004233_abnormal_muscle_weight1.19155914
90MP0008932_abnormal_embryonic_tissue1.18191398
91MP0002060_abnormal_skin_morphology1.17451243
92MP0005666_abnormal_adipose_tissue1.17073149
93MP0000759_abnormal_skeletal_muscle1.16461740
94MP0005369_muscle_phenotype1.15373928
95MP0002085_abnormal_embryonic_tissue1.14700655
96MP0005330_cardiomyopathy1.14269492
97MP0000516_abnormal_urinary_system1.13965962
98MP0005367_renal/urinary_system_phenotyp1.13965962
99MP0002084_abnormal_developmental_patter1.13397359
100MP0001958_emphysema1.12730271
101MP0004185_abnormal_adipocyte_glucose1.11027711
102MP0002086_abnormal_extraembryonic_tissu1.09663602
103MP0001293_anophthalmia1.08569951
104MP0002751_abnormal_autonomic_nervous1.06432058
105MP0002168_other_aberrant_phenotype1.06189796
106MP0008961_abnormal_basal_metabolism1.05396893
107MP0002092_abnormal_eye_morphology1.03217661
108MP0003936_abnormal_reproductive_system1.02711321
109MP0000013_abnormal_adipose_tissue1.02649717
110MP0002118_abnormal_lipid_homeostasis1.01940972
111MP0000428_abnormal_craniofacial_morphol1.01582253
112MP0004264_abnormal_extraembryonic_tissu1.00675638
113MP0005623_abnormal_meninges_morphology1.00201154
114MP0005620_abnormal_muscle_contractility0.99678741
115MP0003077_abnormal_cell_cycle0.99443406
116MP0008995_early_reproductive_senescence0.99073922
117MP0001919_abnormal_reproductive_system0.97469634
118MP0000534_abnormal_ureter_morphology0.97257397
119MP0005375_adipose_tissue_phenotype0.97047163
120MP0005220_abnormal_exocrine_pancreas0.96556407
121MP0010771_integument_phenotype0.96244339
122MP0001727_abnormal_embryo_implantation0.96055231
123MP0006054_spinal_hemorrhage0.95245731
124MP0001730_embryonic_growth_arrest0.95103614
125MP0003045_fibrosis0.94786523
126MP0002909_abnormal_adrenal_gland0.94417651
127MP0001765_abnormal_ion_homeostasis0.94359844
128MP0002136_abnormal_kidney_physiology0.93221024
129MP0004381_abnormal_hair_follicle0.93133970
130MP0005646_abnormal_pituitary_gland0.92786010
131MP0005187_abnormal_penis_morphology0.92736534
132MP0004808_abnormal_hematopoietic_stem0.91139356
133MP0000538_abnormal_urinary_bladder0.90056006
134MP0009053_abnormal_anal_canal0.89766198
135MP0002080_prenatal_lethality0.89715656
136MP0000467_abnormal_esophagus_morphology0.89117641
137MP0003279_aneurysm0.88669174
138MP0003123_paternal_imprinting0.88363436
139MP0003656_abnormal_erythrocyte_physiolo0.88204610
140MP0000003_abnormal_adipose_tissue0.87375571
141MP0002971_abnormal_brown_adipose0.86898424
142MP0003950_abnormal_plasma_membrane0.86806374
143MP0000350_abnormal_cell_proliferation0.86317330
144MP0010630_abnormal_cardiac_muscle0.84847715
145MP0004782_abnormal_surfactant_physiolog0.84599620
146MP0001299_abnormal_eye_distance/0.82684869
147MP0003115_abnormal_respiratory_system0.81584243
148MP0000762_abnormal_tongue_morphology0.81464687
149MP0001340_abnormal_eyelid_morphology0.81289972
150MP0001661_extended_life_span0.80418366
151MP0010368_abnormal_lymphatic_system0.80374768
152MP0005508_abnormal_skeleton_morphology0.78069008
153MP0003868_abnormal_feces_composition0.77573343
154MP0005636_abnormal_mineral_homeostasis0.76433909
155MP0010678_abnormal_skin_adnexa0.76240270
156MP0000598_abnormal_liver_morphology0.75701260
157MP0003943_abnormal_hepatobiliary_system0.75451954
158MP0002254_reproductive_system_inflammat0.75281635
159MP0005075_abnormal_melanosome_morpholog0.74974456
160MP0001286_abnormal_eye_development0.74752771
161MP0001849_ear_inflammation0.71075348
162MP0005584_abnormal_enzyme/coenzyme_acti0.70975521
163MP0002796_impaired_skin_barrier0.70041911
164MP0002928_abnormal_bile_duct0.69910220
165MP0004197_abnormal_fetal_growth/weight/0.68643897
166MP0005647_abnormal_sex_gland0.66421260
167MP0005670_abnormal_white_adipose0.65515914
168MP0001873_stomach_inflammation0.62622401
169MP0002115_abnormal_skeleton_extremities0.61874832
170MP0003453_abnormal_keratinocyte_physiol0.61823790
171MP0003091_abnormal_cell_migration0.61588931
172MP0002135_abnormal_kidney_morphology0.59475284
173MP0003191_abnormal_cellular_cholesterol0.59409710
174MP0002006_tumorigenesis0.59215783

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)5.28695884
2Type 1 muscle fiber predominance (HP:0003803)4.98995214
3Microglossia (HP:0000171)4.95524490
4Muscle fiber inclusion bodies (HP:0100299)4.53951893
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.39642881
6Enlarged penis (HP:0000040)4.38500694
7Absent frontal sinuses (HP:0002688)4.15557238
8Nemaline bodies (HP:0003798)4.03247172
9J-shaped sella turcica (HP:0002680)3.91592390
10Papillary thyroid carcinoma (HP:0002895)3.78355699
11Ulnar deviation of the wrist (HP:0003049)3.66715511
12Breast carcinoma (HP:0003002)3.65738781
13Distal arthrogryposis (HP:0005684)3.59357754
14Thyroid carcinoma (HP:0002890)3.59263633
15Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.53509593
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50079192
17Round ear (HP:0100830)3.48494671
18Increased connective tissue (HP:0009025)3.46023738
19Protrusio acetabuli (HP:0003179)3.40656117
20Hyporeflexia of lower limbs (HP:0002600)3.38859291
21Exercise-induced myalgia (HP:0003738)3.35587691
22Exercise-induced muscle cramps (HP:0003710)3.32503708
23Myopathic facies (HP:0002058)3.28739614
24Septate vagina (HP:0001153)3.27794025
25Chromsome breakage (HP:0040012)3.23805955
26Testicular neoplasm (HP:0010788)3.20432191
27Aortic aneurysm (HP:0004942)3.19978115
28Gout (HP:0001997)3.12234912
29Nephroblastoma (Wilms tumor) (HP:0002667)3.04400124
30Cerebral aneurysm (HP:0004944)3.04028915
31Muscle fiber splitting (HP:0003555)2.99341153
32Abnormality of the frontal sinuses (HP:0002687)2.95227290
33Curly hair (HP:0002212)2.91332125
34Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.86970945
35Embryonal renal neoplasm (HP:0011794)2.86812995
36Hyperglycinuria (HP:0003108)2.85410769
37Deep venous thrombosis (HP:0002625)2.80383489
38Difficulty running (HP:0009046)2.77926177
39Cutaneous melanoma (HP:0012056)2.76048784
40Difficulty climbing stairs (HP:0003551)2.72818039
41Germ cell neoplasia (HP:0100728)2.72081579
42Aortic dissection (HP:0002647)2.71703348
43Termporal pattern (HP:0011008)2.71446967
44Insidious onset (HP:0003587)2.71446967
45Premature rupture of membranes (HP:0001788)2.67157756
46Abnormality of skeletal muscle fiber size (HP:0012084)2.65221564
47Increased variability in muscle fiber diameter (HP:0003557)2.63724997
48Spinal cord lesions (HP:0100561)2.63572784
49Syringomyelia (HP:0003396)2.63572784
50Deep philtrum (HP:0002002)2.60566882
51Hyperglycinemia (HP:0002154)2.58944548
52Micronodular cirrhosis (HP:0001413)2.55479853
53Malignant hyperthermia (HP:0002047)2.54649779
54Abnormality of glycine metabolism (HP:0010895)2.48323418
55Abnormality of serine family amino acid metabolism (HP:0010894)2.48323418
56Popliteal pterygium (HP:0009756)2.48229927
57Myoglobinuria (HP:0002913)2.47356264
58Absent phalangeal crease (HP:0006109)2.45477710
59Metaphyseal cupping (HP:0003021)2.45228199
60Xanthomatosis (HP:0000991)2.45049207
61Transitional cell carcinoma of the bladder (HP:0006740)2.44106925
62Abnormality of the calcaneus (HP:0008364)2.43850378
63Hypoplastic ischia (HP:0003175)2.43312289
64Leiomyosarcoma (HP:0100243)2.42923091
65Uterine leiomyosarcoma (HP:0002891)2.42923091
66Ankle contracture (HP:0006466)2.42672246
67Abnormality of the Achilles tendon (HP:0005109)2.42419478
68Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.41347519
69Intrahepatic cholestasis (HP:0001406)2.38004901
70Hypopigmentation of the fundus (HP:0007894)2.35196914
71Ketosis (HP:0001946)2.33443147
72Gastrointestinal carcinoma (HP:0002672)2.32312808
73Malignant gastrointestinal tract tumors (HP:0006749)2.32312808
74Macroorchidism (HP:0000053)2.30965589
75Mildly elevated creatine phosphokinase (HP:0008180)2.29653905
76Aplasia involving bones of the extremities (HP:0009825)2.28623994
77Aplasia involving bones of the upper limbs (HP:0009823)2.28623994
78Aplasia of the phalanges of the hand (HP:0009802)2.28623994
79Mitral valve prolapse (HP:0001634)2.27917428
80Hypoalphalipoproteinemia (HP:0003233)2.26821824
81Bladder carcinoma (HP:0002862)2.26483458
82Bladder neoplasm (HP:0009725)2.26483458
83Abnormality of the ischium (HP:0003174)2.26189712
84Back pain (HP:0003418)2.25546412
85Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25032166
86Choanal stenosis (HP:0000452)2.24333138
87Deformed sella turcica (HP:0002681)2.24307552
88Calcaneovalgus deformity (HP:0001848)2.23922582
89Neoplasm of the thyroid gland (HP:0100031)2.21050693
90Achilles tendon contracture (HP:0001771)2.20477312
91Spinal rigidity (HP:0003306)2.20130482
92Facial diplegia (HP:0001349)2.19162480
93Coronal craniosynostosis (HP:0004440)2.19120724
94Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18864666
95Pterygium (HP:0001059)2.17843923
96Aplasia of the musculature (HP:0100854)2.17797145
97Calf muscle hypertrophy (HP:0008981)2.17221854
98Thin ribs (HP:0000883)2.16433342
99Uterine neoplasm (HP:0010784)2.16346003
100Hyperammonemia (HP:0001987)2.15962292
101Ketoacidosis (HP:0001993)2.15594464
102Increased density of long bones (HP:0006392)2.15537882
103Meckel diverticulum (HP:0002245)2.15380075
104Muscle hypertrophy of the lower extremities (HP:0008968)2.14999691
105EMG: myopathic abnormalities (HP:0003458)2.13808528
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12888502
107Deformed tarsal bones (HP:0008119)2.12589712
108Scapular winging (HP:0003691)2.12410279
109Hip contracture (HP:0003273)2.10428954
110Aneurysm (HP:0002617)2.09426321
111Abnormality of the calf musculature (HP:0001430)2.07268546
112Fetal akinesia sequence (HP:0001989)2.06929459
113Increased purine levels (HP:0004368)2.05906984
114Hyperuricemia (HP:0002149)2.05906984
115Myocardial infarction (HP:0001658)2.05369148
116Rectal prolapse (HP:0002035)2.03465137
117Frequent falls (HP:0002359)2.02652238
118Abnormality of the umbilical cord (HP:0010881)2.01447777
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.01145336
120Broad metatarsal (HP:0001783)2.01125821
121Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99055599
122Right ventricular cardiomyopathy (HP:0011663)1.98997538
123Absent eyebrow (HP:0002223)1.98224609
124Abnormality of purine metabolism (HP:0004352)1.98222244
125Cardiovascular calcification (HP:0011915)1.97123570
126Proximal tubulopathy (HP:0000114)1.96654371
127Abnormality of the ileum (HP:0001549)1.96437077
128Hypoglycemic coma (HP:0001325)1.93780843
129Short humerus (HP:0005792)1.93355797
130Hypolipoproteinemia (HP:0010981)1.91722389
131Alopecia of scalp (HP:0002293)1.90988638
132Abnormality of chromosome stability (HP:0003220)1.89304880
133Myelomeningocele (HP:0002475)1.88878110
134Abnormal finger flexion creases (HP:0006143)1.88756511
135Long toe (HP:0010511)1.87832783
136Cervical subluxation (HP:0003308)1.87663692
137Concave nail (HP:0001598)1.87202114
138EMG: neuropathic changes (HP:0003445)1.86850648
139Abnormal cartilage morphology (HP:0002763)1.86794733
140Cystic hygroma (HP:0000476)1.86623504
141Spastic diplegia (HP:0001264)1.85951505
142Lymphangioma (HP:0100764)1.85317407
143Aplasia/hypoplasia of the humerus (HP:0006507)1.84613795
144Complement deficiency (HP:0004431)1.84208512
145Upper limb amyotrophy (HP:0009129)1.82891802
146Distal upper limb amyotrophy (HP:0007149)1.82891802
147Selective tooth agenesis (HP:0001592)1.82771130
148Generalized muscle weakness (HP:0003324)1.81889781
149Distal lower limb muscle weakness (HP:0009053)1.80439186
150Slender build (HP:0001533)1.78897699
151Osteolytic defects of the hand bones (HP:0009699)1.78853200
152Osteolytic defects of the phalanges of the hand (HP:0009771)1.78853200
153Limb-girdle muscle atrophy (HP:0003797)1.78475789
154Vascular calcification (HP:0004934)1.78448887
155Rhabdomyolysis (HP:0003201)1.78439084
156Malnutrition (HP:0004395)1.78057903
157Abnormality of sulfur amino acid metabolism (HP:0004339)1.78055460
158Ovarian neoplasm (HP:0100615)1.78017674
159Absent eyelashes (HP:0000561)1.77475499
160Hypoglycemic seizures (HP:0002173)1.77444424
161Dilatation of the ascending aorta (HP:0005111)1.76842644
162Hepatocellular carcinoma (HP:0001402)1.76813495
163Embryonal neoplasm (HP:0002898)1.76347618
164Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76135756
165Bifid tongue (HP:0010297)1.75703159
166Bicornuate uterus (HP:0000813)1.75082399
167Increased mean platelet volume (HP:0011877)1.74629710
168Exostoses (HP:0100777)1.73211431
169High pitched voice (HP:0001620)1.72003946
170Menstrual irregularities (HP:0000858)1.71856309
171Renal cell carcinoma (HP:0005584)1.70802838
172Ectopic anus (HP:0004397)1.67796182
173Abnormality of the preputium (HP:0100587)1.65699783
174Gonadal dysgenesis (HP:0000133)1.64569858
175Wide nose (HP:0000445)1.61800598
176Buphthalmos (HP:0000557)1.58784091
177Midline defect of the nose (HP:0004122)1.58024014
178Maternal diabetes (HP:0009800)1.57652513
179Abnormalities of placenta or umbilical cord (HP:0001194)1.56999652
180Short nail (HP:0001799)1.56547752
181Abnormal lung lobation (HP:0002101)1.54879101
182Clitoromegaly (HP:0000057)1.54815937
183Advanced eruption of teeth (HP:0006288)1.54667446
184Short hallux (HP:0010109)1.54424004
185Esophageal varix (HP:0002040)1.53145428
186Progressive external ophthalmoplegia (HP:0000590)1.53094737
187Biliary tract neoplasm (HP:0100574)1.52967267
188Facial cleft (HP:0002006)1.51402780
189Abnormality of calcium-phosphate metabolism (HP:0100530)1.48853220
190Abnormality of the sella turcica (HP:0002679)1.48286803
191Neoplasm of the adrenal cortex (HP:0100641)1.48210939
192Abnormality of the lacrimal duct (HP:0011481)1.46334199
193Meningioma (HP:0002858)1.46303057
194Tetraparesis (HP:0002273)1.45778399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.25271384
2TTN3.37313405
3PIK3CA3.21642178
4NME22.91937190
5PKN22.77634182
6EEF2K2.74488198
7BCKDK2.73045051
8SIK12.50531806
9EIF2AK12.48991977
10OBSCN2.43655165
11PBK2.36079391
12MUSK2.31649827
13NEK62.31000263
14LATS12.25958625
15DDR22.13231780
16PIK3CG1.97645066
17PDK41.97017309
18PDK31.97017309
19ERN11.91510868
20RIPK11.90077189
21FRK1.81463893
22FGFR41.76451608
23PDGFRA1.74788372
24EIF2AK31.74694764
25TGFBR21.73471956
26PDK21.65697372
27TTK1.62828922
28TRIM281.62262544
29MAP3K31.48891428
30WNK41.47221030
31PTK61.46697284
32MAPKAPK31.44999097
33SMG11.44843374
34MAP3K101.43243218
35MAP3K121.43230645
36TAF11.42756381
37MAP2K31.37424019
38LRRK21.36454729
39TSSK61.34062745
40MAP3K71.33151077
41SRPK11.32924301
42CHUK1.29869746
43STK391.29157065
44AKT31.28079260
45CDK61.26608561
46RPS6KB11.22019045
47STK101.20636663
48FER1.18359733
49CDK121.16714093
50STK31.16351866
51BRSK21.14790931
52NEK11.13743250
53FGFR31.08968303
54MET1.06532310
55MTOR1.06490145
56PAK21.05087362
57EPHA21.03504567
58ICK1.02052505
59CDK70.98505614
60BRD40.98502880
61WEE10.97469216
62EIF2AK20.96931815
63STK380.87751177
64FGFR20.87537676
65JAK10.86873803
66STK38L0.86473358
67BMX0.86206014
68DMPK0.85947302
69STK240.83537983
70BCR0.82855643
71DYRK1B0.82344266
72PHKG20.81574501
73PHKG10.81574501
74ERBB30.81210023
75MAP2K40.80975204
76PTK20.79636195
77IRAK30.78748131
78MST1R0.78071502
79FGFR10.77888611
80PASK0.77209897
81SIK30.76742082
82TRPM70.74119779
83MAP2K20.73745744
84OXSR10.73246816
85MAP3K20.73219727
86CAMK1D0.72312395
87MKNK10.70821352
88DYRK30.70790433
89JAK20.70668132
90TYRO30.70592661
91RPS6KB20.70028709
92RPS6KA40.69666989
93WNK10.69520358
94MAPK110.68862269
95SCYL20.67890108
96PRKAA10.67799895
97MOS0.66156136
98YES10.65914069
99RET0.65146818
100MAPK120.64557760
101MST40.64180116
102GSK3A0.64050457
103PLK30.63421617
104MAP2K10.60498651
105PAK30.57957389
106CLK10.57816129
107SGK30.56728824
108CSF1R0.56501623
109PDGFRB0.56493173
110BUB10.56122211
111MAP3K90.55925333
112PRKAA20.55486081
113NEK90.55400932
114CAMK1G0.53662513
115RPS6KA20.52372992
116MKNK20.51726281
117PNCK0.50903378
118PLK10.50684317
119PRKD30.50583144
120MELK0.49777184
121PRKCH0.49678639
122EPHB10.49172755
123LATS20.48755172
124GRK60.48690467
125CHEK20.47874876
126ZAK0.46637719
127MYLK0.46455875
128ZAP700.46308191
129EPHA30.46224484
130ITK0.46052600
131PIM10.45698471
132FLT30.45583641
133CDK90.44889993
134PRKCI0.44837664
135TAOK30.44727789
136PDK10.43990159
137PAK40.43856212
138TAOK10.41564067
139CAMK2G0.40695514
140ROCK10.40461424
141CAMK2B0.40250727
142AURKB0.39732229
143PRKCE0.39373582
144ALK0.39140605
145CDC70.38373743
146RPS6KA10.35206161
147CAMKK10.34589914
148CAMK2D0.34539865
149NUAK10.34210769
150AKT20.33874676
151ILK0.33736523
152TXK0.33715282
153STK40.33548871
154MAPKAPK20.33408662
155TESK10.32638633
156TYK20.32521514
157CDK40.32197452
158AURKA0.32125334
159LMTK20.31928291

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.59999288
2Thyroid cancer_Homo sapiens_hsa052163.03354977
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93553881
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61152548
5Propanoate metabolism_Homo sapiens_hsa006402.48878998
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.44994683
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43626357
8Arginine biosynthesis_Homo sapiens_hsa002202.42749022
9Fatty acid degradation_Homo sapiens_hsa000712.42081113
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41201823
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.31596166
12Fatty acid metabolism_Homo sapiens_hsa012121.94244586
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88077697
14Tryptophan metabolism_Homo sapiens_hsa003801.86403712
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84371830
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68532600
17PPAR signaling pathway_Homo sapiens_hsa033201.66176014
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65664860
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60871185
20Bile secretion_Homo sapiens_hsa049761.59542556
21RNA transport_Homo sapiens_hsa030131.58388927
22Melanoma_Homo sapiens_hsa052181.56207390
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52467024
24Pyruvate metabolism_Homo sapiens_hsa006201.43589884
25Starch and sucrose metabolism_Homo sapiens_hsa005001.42002670
26Butanoate metabolism_Homo sapiens_hsa006501.40614589
27Steroid biosynthesis_Homo sapiens_hsa001001.39720227
28Pentose phosphate pathway_Homo sapiens_hsa000301.38136795
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37737533
30Protein digestion and absorption_Homo sapiens_hsa049741.37292883
31Complement and coagulation cascades_Homo sapiens_hsa046101.34222986
32Carbon metabolism_Homo sapiens_hsa012001.33090805
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31480728
34Insulin resistance_Homo sapiens_hsa049311.29861289
35Non-homologous end-joining_Homo sapiens_hsa034501.29066973
36Selenocompound metabolism_Homo sapiens_hsa004501.28097759
37Fatty acid biosynthesis_Homo sapiens_hsa000611.26237861
38Fatty acid elongation_Homo sapiens_hsa000621.25827817
39Lysine degradation_Homo sapiens_hsa003101.24860080
40Cell cycle_Homo sapiens_hsa041101.24586054
41beta-Alanine metabolism_Homo sapiens_hsa004101.23242986
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21923228
43N-Glycan biosynthesis_Homo sapiens_hsa005101.19835792
44Biosynthesis of amino acids_Homo sapiens_hsa012301.19603187
45ECM-receptor interaction_Homo sapiens_hsa045121.16935812
46mRNA surveillance pathway_Homo sapiens_hsa030151.16534097
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15791024
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15302859
49Peroxisome_Homo sapiens_hsa041461.09678080
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.08529488
51p53 signaling pathway_Homo sapiens_hsa041151.08260825
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06604704
53Focal adhesion_Homo sapiens_hsa045101.05705874
54mTOR signaling pathway_Homo sapiens_hsa041501.05323591
55Sulfur metabolism_Homo sapiens_hsa009201.03540867
56Arginine and proline metabolism_Homo sapiens_hsa003301.03089767
57Renal cell carcinoma_Homo sapiens_hsa052111.02887277
58Non-small cell lung cancer_Homo sapiens_hsa052231.02428136
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01490314
60Inositol phosphate metabolism_Homo sapiens_hsa005620.96485447
61Sphingolipid metabolism_Homo sapiens_hsa006000.95814541
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95155844
63Glycerolipid metabolism_Homo sapiens_hsa005610.94868629
64ErbB signaling pathway_Homo sapiens_hsa040120.94753356
65Glucagon signaling pathway_Homo sapiens_hsa049220.94017674
66Fat digestion and absorption_Homo sapiens_hsa049750.93130218
67MicroRNAs in cancer_Homo sapiens_hsa052060.92917190
68Adherens junction_Homo sapiens_hsa045200.92913018
69AMPK signaling pathway_Homo sapiens_hsa041520.92660383
70Glioma_Homo sapiens_hsa052140.90774297
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89767939
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89045837
73Nucleotide excision repair_Homo sapiens_hsa034200.88168966
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88131689
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.87519585
76One carbon pool by folate_Homo sapiens_hsa006700.87339561
77Chemical carcinogenesis_Homo sapiens_hsa052040.87162971
78ABC transporters_Homo sapiens_hsa020100.86902812
79Mismatch repair_Homo sapiens_hsa034300.85976898
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85769026
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.85428887
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85295570
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84879012
84Spliceosome_Homo sapiens_hsa030400.84751440
85Choline metabolism in cancer_Homo sapiens_hsa052310.84395088
86Proteasome_Homo sapiens_hsa030500.84241393
87Basal cell carcinoma_Homo sapiens_hsa052170.82304044
88Insulin signaling pathway_Homo sapiens_hsa049100.82170923
89Vitamin digestion and absorption_Homo sapiens_hsa049770.81172958
90Proteoglycans in cancer_Homo sapiens_hsa052050.80438646
91Circadian rhythm_Homo sapiens_hsa047100.80071381
92Phenylalanine metabolism_Homo sapiens_hsa003600.80008496
93Wnt signaling pathway_Homo sapiens_hsa043100.79544236
94Thyroid hormone synthesis_Homo sapiens_hsa049180.78892259
95Amoebiasis_Homo sapiens_hsa051460.76158623
96Acute myeloid leukemia_Homo sapiens_hsa052210.75953245
97Dilated cardiomyopathy_Homo sapiens_hsa054140.74969279
98Basal transcription factors_Homo sapiens_hsa030220.73974659
99Prolactin signaling pathway_Homo sapiens_hsa049170.73554016
100DNA replication_Homo sapiens_hsa030300.73318481
101Vibrio cholerae infection_Homo sapiens_hsa051100.72776561
102Fanconi anemia pathway_Homo sapiens_hsa034600.72713758
103Bladder cancer_Homo sapiens_hsa052190.69524092
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68260876
105Hedgehog signaling pathway_Homo sapiens_hsa043400.67533758
106Colorectal cancer_Homo sapiens_hsa052100.67347356
107Protein export_Homo sapiens_hsa030600.64579293
108Tyrosine metabolism_Homo sapiens_hsa003500.64025842
109Small cell lung cancer_Homo sapiens_hsa052220.63678179
110Alcoholism_Homo sapiens_hsa050340.62006732
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61731182
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61535126
113TGF-beta signaling pathway_Homo sapiens_hsa043500.59592812
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58648765
115FoxO signaling pathway_Homo sapiens_hsa040680.58579775
116Pancreatic cancer_Homo sapiens_hsa052120.56073993
117Pathways in cancer_Homo sapiens_hsa052000.54794852
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54699260
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54626694
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54355054
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.52961720
122Hippo signaling pathway_Homo sapiens_hsa043900.51905360
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51646826
124Histidine metabolism_Homo sapiens_hsa003400.50926361
125Tight junction_Homo sapiens_hsa045300.48521124
126Retinol metabolism_Homo sapiens_hsa008300.48461538
127Caffeine metabolism_Homo sapiens_hsa002320.48394565
128Fructose and mannose metabolism_Homo sapiens_hsa000510.47694349
129Pancreatic secretion_Homo sapiens_hsa049720.46093581
130Prostate cancer_Homo sapiens_hsa052150.45917735
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43609123
132Oocyte meiosis_Homo sapiens_hsa041140.43584280
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.43268141
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.41640636
135Renin-angiotensin system_Homo sapiens_hsa046140.41123636
136Dorso-ventral axis formation_Homo sapiens_hsa043200.40458307
137Chronic myeloid leukemia_Homo sapiens_hsa052200.39664155
138Glutathione metabolism_Homo sapiens_hsa004800.37106021
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36909717
140Vitamin B6 metabolism_Homo sapiens_hsa007500.35975931
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.31019878
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30298660
143Staphylococcus aureus infection_Homo sapiens_hsa051500.30138473
144Endometrial cancer_Homo sapiens_hsa052130.29536921
145Galactose metabolism_Homo sapiens_hsa000520.28949292
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28136472
147Gastric acid secretion_Homo sapiens_hsa049710.27777697
148Estrogen signaling pathway_Homo sapiens_hsa049150.26817083
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26207748
150Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.26065357

Most similar genes based on co-expression Upload to Enrichr

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