TMEM65

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of calcium ion (GO:0005513)4.17067244
2plasma membrane repair (GO:0001778)4.08666949
3sarcoplasmic reticulum calcium ion transport (GO:0070296)4.00662271
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.73672941
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.66697227
6synaptic vesicle maturation (GO:0016188)3.63420800
7regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.48519882
8protein targeting to Golgi (GO:0000042)3.44182651
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42508064
10regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.42181729
11negative regulation of potassium ion transmembrane transport (GO:1901380)3.37498754
12activation of protein kinase A activity (GO:0034199)3.35872059
13macroautophagy (GO:0016236)3.33300930
14cytoplasmic mRNA processing body assembly (GO:0033962)3.30095901
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.29534857
16regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.28893187
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.25959238
18actin-mediated cell contraction (GO:0070252)3.23405845
19regulation of synaptic vesicle exocytosis (GO:2000300)3.20540907
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19085704
21atrial cardiac muscle cell action potential (GO:0086014)3.14586507
22synaptic vesicle exocytosis (GO:0016079)3.11831498
23relaxation of cardiac muscle (GO:0055119)3.11076434
24negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09808946
25regulation of cell communication by electrical coupling (GO:0010649)3.08347484
26layer formation in cerebral cortex (GO:0021819)3.05187482
27COPI coating of Golgi vesicle (GO:0048205)3.04574971
28Golgi transport vesicle coating (GO:0048200)3.04574971
29interkinetic nuclear migration (GO:0022027)3.04158663
30establishment of protein localization to Golgi (GO:0072600)3.03689038
31cardiac muscle hypertrophy (GO:0003300)3.03525469
32neuronal action potential propagation (GO:0019227)3.00286905
33retrograde transport, vesicle recycling within Golgi (GO:0000301)2.99005575
34membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.97054030
35cardiac myofibril assembly (GO:0055003)2.96275816
36cell communication involved in cardiac conduction (GO:0086065)2.92188793
37actomyosin structure organization (GO:0031032)2.88093274
38glutamate secretion (GO:0014047)2.86913266
39nucleus localization (GO:0051647)2.85658901
40striated muscle hypertrophy (GO:0014897)2.83746509
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83237803
42ionotropic glutamate receptor signaling pathway (GO:0035235)2.83048055
43striated muscle contraction (GO:0006941)2.83047425
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.82791493
45cell communication by electrical coupling (GO:0010644)2.79948463
46cardiac muscle tissue morphogenesis (GO:0055008)2.79369837
47myotube differentiation (GO:0014902)2.79311883
48heart valve formation (GO:0003188)2.78364355
49regulation of membrane repolarization (GO:0060306)2.77827047
50regulation of calcium ion transmembrane transport (GO:1903169)2.77751984
51regulation of calcium ion transmembrane transporter activity (GO:1901019)2.77751984
52potassium ion import (GO:0010107)2.77577635
53sarcomere organization (GO:0045214)2.76503065
54vocalization behavior (GO:0071625)2.74300238
55neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.71643008
56positive regulation of potassium ion transport (GO:0043268)2.70889219
57locomotory exploration behavior (GO:0035641)2.70472306
58positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.69128180
59startle response (GO:0001964)2.68295256
60regulation of synaptic vesicle transport (GO:1902803)2.68222958
61actin filament-based movement (GO:0030048)2.68022743
62membrane repolarization during action potential (GO:0086011)2.67233797
63vesicle transport along microtubule (GO:0047496)2.66259799
64proline transport (GO:0015824)2.65859092
65ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.63052283
66regulation of striated muscle contraction (GO:0006942)2.62768591
67myofibril assembly (GO:0030239)2.62718973
68insulin secretion (GO:0030073)2.60361281
69regulation of the force of heart contraction (GO:0002026)2.59460292
70neuromuscular junction development (GO:0007528)2.58951082
71cellular potassium ion homeostasis (GO:0030007)2.58051714
72positive regulation of potassium ion transmembrane transport (GO:1901381)2.57348174
73Notch signaling involved in heart development (GO:0061314)2.56106497
74positive regulation of cardiac muscle cell differentiation (GO:2000727)2.55818220
75negative regulation of calcium ion transmembrane transport (GO:1903170)2.54801236
76negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.54801236
77protein localization to Golgi apparatus (GO:0034067)2.53419386
78regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.53416831
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.52758844
80membrane repolarization (GO:0086009)2.52104278
81cellular response to epinephrine stimulus (GO:0071872)2.51994823
82adult heart development (GO:0007512)2.51883061
83muscle tissue morphogenesis (GO:0060415)2.51220144
84establishment of nucleus localization (GO:0040023)2.48537195
85organelle transport along microtubule (GO:0072384)2.48191148
86dendritic spine morphogenesis (GO:0060997)2.47414363
87protein localization to endosome (GO:0036010)2.47285450
88positive regulation of vesicle fusion (GO:0031340)2.47269583
89retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.45799090
90dendrite morphogenesis (GO:0048813)2.45191974
91growth hormone secretion (GO:0030252)2.44943358
92regulation of cardiac muscle contraction (GO:0055117)2.44910528
93lipid translocation (GO:0034204)2.44644811
94phospholipid translocation (GO:0045332)2.44644811
95negative regulation of neurotransmitter transport (GO:0051589)2.44176704
96desmosome organization (GO:0002934)2.43829660
97relaxation of muscle (GO:0090075)2.43656852
98cardiac conduction (GO:0061337)2.42525298
99phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42388137
100regulation of potassium ion transmembrane transport (GO:1901379)2.41906672
101cellular response to monoamine stimulus (GO:0071868)2.41547019
102cellular response to catecholamine stimulus (GO:0071870)2.41547019
103cerebellar Purkinje cell layer development (GO:0021680)2.40719164
104regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.40138227
105cardiac muscle cell action potential (GO:0086001)2.39856110
106sodium ion export (GO:0071436)2.39593267
107chemosensory behavior (GO:0007635)2.39064820
108neurotransmitter secretion (GO:0007269)2.38860318
109regulation of synapse structural plasticity (GO:0051823)2.38371625
110cellular response to ethanol (GO:0071361)2.38366191
111glutamate receptor signaling pathway (GO:0007215)2.38297676
112positive regulation of cation channel activity (GO:2001259)2.38058247
113early endosome to late endosome transport (GO:0045022)2.37451364
114regulation of sarcomere organization (GO:0060297)2.37435005
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.37339483
116regulation of cAMP-dependent protein kinase activity (GO:2000479)2.37244876
117muscle filament sliding (GO:0030049)2.37215370
118actin-myosin filament sliding (GO:0033275)2.37215370
119relaxation of smooth muscle (GO:0044557)2.36999057
120regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.36449724
121cardiac muscle contraction (GO:0060048)2.36231202
122growth hormone receptor signaling pathway (GO:0060396)2.36146518
123regulation of potassium ion transmembrane transporter activity (GO:1901016)2.35095461
124muscle hypertrophy (GO:0014896)2.35083094
125regulation of skeletal muscle contraction (GO:0014819)2.33885972
126nerve growth factor signaling pathway (GO:0038180)2.33818085
127cerebral cortex radially oriented cell migration (GO:0021799)2.33458996
128neuron recognition (GO:0008038)2.32765285
129type B pancreatic cell development (GO:0003323)2.32205705
130neuron remodeling (GO:0016322)2.31922541
131regulation of vesicle fusion (GO:0031338)2.31125659
132regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.30495522
133suckling behavior (GO:0001967)2.30335084
134cAMP catabolic process (GO:0006198)2.28355789
135regulation of pigment cell differentiation (GO:0050932)2.27237639
136ventricular trabecula myocardium morphogenesis (GO:0003222)2.27088338
137regulation of cardiac muscle cell contraction (GO:0086004)2.26430129
138response to monoamine (GO:0071867)2.26019478
139response to catecholamine (GO:0071869)2.26019478
140neuron cell-cell adhesion (GO:0007158)2.25892158
141central nervous system neuron axonogenesis (GO:0021955)2.25721429
142positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.25335271
143axonal fasciculation (GO:0007413)2.25276411
144negative regulation of neurotransmitter secretion (GO:0046929)2.25181412
145myoblast fusion (GO:0007520)2.25060190
146regulation of ARF protein signal transduction (GO:0032012)2.24957025
147presynaptic membrane assembly (GO:0097105)2.24902819
148adrenergic receptor signaling pathway (GO:0071875)2.24700708
149regulation of relaxation of muscle (GO:1901077)2.24684307
150cellular response to glucagon stimulus (GO:0071377)2.24621125
151response to epinephrine (GO:0071871)2.23862850
152coronary vasculature morphogenesis (GO:0060977)2.23326533
153response to inactivity (GO:0014854)2.23228553
154embryonic retina morphogenesis in camera-type eye (GO:0060059)2.23215433
155regulation of actin filament-based movement (GO:1903115)2.22679333
156cardiac muscle cell action potential involved in contraction (GO:0086002)2.22205251
157regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.22178784
158membrane depolarization during action potential (GO:0086010)2.22046112
159positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.21812566
160ventricular cardiac muscle cell action potential (GO:0086005)2.21677719
161cerebellar Purkinje cell differentiation (GO:0021702)2.21191616
162negative regulation of potassium ion transport (GO:0043267)2.21164232
163regulation of glutamate receptor signaling pathway (GO:1900449)2.21085891
164regulation of heart rate by cardiac conduction (GO:0086091)2.20880013
165regulation of cation channel activity (GO:2001257)2.20772374
166cardiac cell development (GO:0055006)2.20599882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.92641039
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43721328
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39226547
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35825118
5GBX2_23144817_ChIP-Seq_PC3_Human2.35706247
6SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22992664
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17316716
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08273066
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08273066
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06305527
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02356540
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.01297048
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00752185
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98882996
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97753354
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90564811
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87056285
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85540261
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.82654618
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.82293810
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77955584
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.76178999
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.74719771
24* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70159454
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.68744401
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.68249791
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66975729
28DROSHA_22980978_ChIP-Seq_HELA_Human1.63556191
29AR_21572438_ChIP-Seq_LNCaP_Human1.62836780
30ZNF274_21170338_ChIP-Seq_K562_Hela1.62165238
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60067736
32* REST_21632747_ChIP-Seq_MESCs_Mouse1.55841876
33* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52224112
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.51721146
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51183849
36SMAD4_21799915_ChIP-Seq_A2780_Human1.50859912
37* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50153133
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48493131
39* PIAS1_25552417_ChIP-Seq_VCAP_Human1.47486739
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47135061
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45466703
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45396190
43FUS_26573619_Chip-Seq_HEK293_Human1.43024607
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41045790
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39121728
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38620091
47* ER_23166858_ChIP-Seq_MCF-7_Human1.38617844
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37905136
49AHR_22903824_ChIP-Seq_MCF-7_Human1.36922164
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.34551752
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.34541328
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.31789034
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30645934
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.30269977
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29633634
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.28867369
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.28555247
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27545716
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26503902
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26274244
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26012990
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26012990
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24923258
64BCAT_22108803_ChIP-Seq_LS180_Human1.24544896
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24245897
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24188013
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23624325
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23118595
69STAT3_23295773_ChIP-Seq_U87_Human1.22845688
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22229143
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21902414
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.21838190
73ZNF263_19887448_ChIP-Seq_K562_Human1.21122052
74* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20522293
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20507909
76* SMAD3_21741376_ChIP-Seq_EPCs_Human1.19919935
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.18000920
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.16706677
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16398401
80P300_19829295_ChIP-Seq_ESCs_Human1.14400966
81EWS_26573619_Chip-Seq_HEK293_Human1.13999897
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13817955
83RXR_22108803_ChIP-Seq_LS180_Human1.13318673
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13036419
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13036419
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12810858
87* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12777630
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12328558
89* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12007000
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11994840
91* AR_25329375_ChIP-Seq_VCAP_Human1.11893051
92* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11201452
93KDM2B_26808549_Chip-Seq_REH_Human1.11195275
94* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11101072
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09460673
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.09402234
97TP53_18474530_ChIP-ChIP_U2OS_Human1.08829412
98P53_22387025_ChIP-Seq_ESCs_Mouse1.07778539
99TP53_16413492_ChIP-PET_HCT116_Human1.06939092
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.06829761
101RNF2_27304074_Chip-Seq_NSC_Mouse1.06752717
102AR_19668381_ChIP-Seq_PC3_Human1.06623881
103TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05897342
104CJUN_26792858_Chip-Seq_BT549_Human1.05443326
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05137353
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04983166
107FLI1_27457419_Chip-Seq_LIVER_Mouse1.04702141
108TAF15_26573619_Chip-Seq_HEK293_Human1.04288444
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04253874
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03480170
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02902895
112* KDM2B_26808549_Chip-Seq_K562_Human1.02758718
113VDR_22108803_ChIP-Seq_LS180_Human1.02138957
114TCF4_23295773_ChIP-Seq_U87_Human0.97644868
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97179504
116* RING1B_27294783_Chip-Seq_ESCs_Mouse0.94927847
117* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94591928
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94362135
119* TBX20_22328084_ChIP-Seq_HEART_Mouse0.93671662
120* TBX20_22080862_ChIP-Seq_HEART_Mouse0.93671662
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93161537
122TP63_23658742_ChIP-Seq_EP156T_Human0.93011427
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.92773313
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.92754434
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92063946
126IGF1R_20145208_ChIP-Seq_DFB_Human0.91790681
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.91441623
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89572338
129* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89383688
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88219390
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.88109957
132ERG_21242973_ChIP-ChIP_JURKAT_Human0.87790520
133RUNX2_22187159_ChIP-Seq_PCA_Human0.87703397
134* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87515970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.96283960
2MP0000569_abnormal_digit_pigmentation3.81495855
3MP0009780_abnormal_chondrocyte_physiolo3.33571775
4MP0000013_abnormal_adipose_tissue2.86599934
5MP0000751_myopathy2.83727213
6MP0004270_analgesia2.76023336
7MP0004859_abnormal_synaptic_plasticity2.73033082
8MP0004145_abnormal_muscle_electrophysio2.72713740
9MP0002877_abnormal_melanocyte_morpholog2.71540539
10MP0002909_abnormal_adrenal_gland2.63321017
11MP0004084_abnormal_cardiac_muscle2.39414112
12MP0004215_abnormal_myocardial_fiber2.29541611
13MP0004036_abnormal_muscle_relaxation2.21593751
14MP0003635_abnormal_synaptic_transmissio2.03344271
15MP0002127_abnormal_cardiovascular_syste1.91890711
16MP0004043_abnormal_pH_regulation1.91807144
17MP0000749_muscle_degeneration1.91123245
18MP0003283_abnormal_digestive_organ1.90613154
19MP0004885_abnormal_endolymph1.88742458
20MP0004130_abnormal_muscle_cell1.83317064
21MP0003646_muscle_fatigue1.80802069
22MP0000747_muscle_weakness1.71056403
23MP0002234_abnormal_pharynx_morphology1.69823229
24MP0004484_altered_response_of1.66915775
25MP0010368_abnormal_lymphatic_system1.65210327
26MP0000383_abnormal_hair_follicle1.64735399
27MP0002972_abnormal_cardiac_muscle1.60078137
28MP0010678_abnormal_skin_adnexa1.59589730
29MP0005620_abnormal_muscle_contractility1.59380032
30MP0002734_abnormal_mechanical_nocicepti1.58945861
31MP0001299_abnormal_eye_distance/1.58899740
32MP0010386_abnormal_urinary_bladder1.56669586
33MP0004087_abnormal_muscle_fiber1.54950346
34MP0010234_abnormal_vibrissa_follicle1.54790557
35MP0005275_abnormal_skin_tensile1.52681697
36MP0002063_abnormal_learning/memory/cond1.48651310
37MP0004185_abnormal_adipocyte_glucose1.47552115
38MP0002693_abnormal_pancreas_physiology1.46182604
39MP0009046_muscle_twitch1.45301788
40MP0004085_abnormal_heartbeat1.45196739
41MP0000003_abnormal_adipose_tissue1.44658439
42MP0002106_abnormal_muscle_physiology1.43840494
43MP0005330_cardiomyopathy1.42835442
44MP0002332_abnormal_exercise_endurance1.37023481
45MP0002064_seizures1.36468472
46MP0003828_pulmonary_edema1.35810153
47MP0003880_abnormal_central_pattern1.35609773
48MP0005187_abnormal_penis_morphology1.34872693
49MP0003137_abnormal_impulse_conducting1.34503941
50MP0002896_abnormal_bone_mineralization1.30669510
51MP0009745_abnormal_behavioral_response1.30327517
52MP0005369_muscle_phenotype1.30188632
53MP0000759_abnormal_skeletal_muscle1.29415869
54MP0001944_abnormal_pancreas_morphology1.25335751
55MP0000750_abnormal_muscle_regeneration1.24205273
56MP0004858_abnormal_nervous_system1.21832853
57MP0002733_abnormal_thermal_nociception1.20905578
58MP0003787_abnormal_imprinting1.20794588
59MP0008775_abnormal_heart_ventricle1.20391320
60MP0008569_lethality_at_weaning1.19474488
61MP0002572_abnormal_emotion/affect_behav1.18755436
62MP0006054_spinal_hemorrhage1.18362613
63MP0003329_amyloid_beta_deposits1.17503274
64MP0005623_abnormal_meninges_morphology1.17482421
65MP0003690_abnormal_glial_cell1.17019934
66MP0002272_abnormal_nervous_system1.15612158
67MP0001984_abnormal_olfaction1.15566714
68MP0008961_abnormal_basal_metabolism1.14404466
69MP0004233_abnormal_muscle_weight1.13241931
70MP0003950_abnormal_plasma_membrane1.12601867
71MP0000733_abnormal_muscle_development1.12270973
72MP0001970_abnormal_pain_threshold1.10971398
73MP0005375_adipose_tissue_phenotype1.10066033
74MP0002269_muscular_atrophy1.08535842
75MP0005167_abnormal_blood-brain_barrier1.07577822
76MP0003045_fibrosis1.07160447
77MP0002928_abnormal_bile_duct1.05315193
78MP0005379_endocrine/exocrine_gland_phen1.02990188
79MP0005595_abnormal_vascular_smooth1.02555425
80MP0002184_abnormal_innervation1.01544577
81MP0002078_abnormal_glucose_homeostasis1.00696918
82MP0003634_abnormal_glial_cell0.99631224
83MP0005248_abnormal_Harderian_gland0.98978680
84MP0005409_darkened_coat_color0.98002325
85MP0000427_abnormal_hair_cycle0.97935022
86MP0001486_abnormal_startle_reflex0.97907164
87MP0002067_abnormal_sensory_capabilities0.97550706
88MP0004924_abnormal_behavior0.97492706
89MP0005386_behavior/neurological_phenoty0.97492706
90MP0002108_abnormal_muscle_morphology0.96885732
91MP0001544_abnormal_cardiovascular_syste0.96254684
92MP0005385_cardiovascular_system_phenoty0.96254684
93MP0000579_abnormal_nail_morphology0.95827356
94MP0004510_myositis0.95216585
95MP0005666_abnormal_adipose_tissue0.94650597
96MP0003221_abnormal_cardiomyocyte_apopto0.92654993
97MP0006138_congestive_heart_failure0.92380878
98MP0002735_abnormal_chemical_nociception0.92295912
99MP0003195_calcinosis0.92169265
100MP0002638_abnormal_pupillary_reflex0.91837302
101MP0001440_abnormal_grooming_behavior0.91479210
102MP0001968_abnormal_touch/_nociception0.90496424
103MP0000778_abnormal_nervous_system0.90002939
104MP0003632_abnormal_nervous_system0.89560216
105MP0004811_abnormal_neuron_physiology0.88658183
106MP0000955_abnormal_spinal_cord0.88171994
107MP0003122_maternal_imprinting0.87064027
108MP0010630_abnormal_cardiac_muscle0.85942150
109MP0001501_abnormal_sleep_pattern0.84370265
110MP0001851_eye_inflammation0.83883008
111MP0005535_abnormal_body_temperature0.83834881
112MP0003091_abnormal_cell_migration0.83747140
113MP0002557_abnormal_social/conspecific_i0.80087956
114MP0006072_abnormal_retinal_apoptosis0.80026933
115MP0004272_abnormal_basement_membrane0.79812208
116MP0002796_impaired_skin_barrier0.78914559
117MP0000266_abnormal_heart_morphology0.78714942
118MP0009053_abnormal_anal_canal0.77751302
119MP0002925_abnormal_cardiovascular_devel0.76480562
120MP0002066_abnormal_motor_capabilities/c0.76248843
121MP0003633_abnormal_nervous_system0.75977606
122MP0005423_abnormal_somatic_nervous0.75887925
123MP0002876_abnormal_thyroid_physiology0.75585183
124MP0002009_preneoplasia0.75427946
125MP0006276_abnormal_autonomic_nervous0.74666973
126MP0002882_abnormal_neuron_morphology0.74650718
127MP0001879_abnormal_lymphatic_vessel0.74512092
128MP0002128_abnormal_blood_circulation0.73405316
129MP0005646_abnormal_pituitary_gland0.72771897
130MP0003631_nervous_system_phenotype0.72719307
131MP0003300_gastrointestinal_ulcer0.72695810
132MP0000678_abnormal_parathyroid_gland0.72627600
133MP0002168_other_aberrant_phenotype0.71225588

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)3.95796295
2Sudden death (HP:0001699)3.87077262
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.77680465
4Hyporeflexia of lower limbs (HP:0002600)3.67630488
5Calf muscle hypertrophy (HP:0008981)3.64309247
6Muscle hypertrophy of the lower extremities (HP:0008968)3.61212228
7Exercise-induced muscle cramps (HP:0003710)3.29919415
8Focal motor seizures (HP:0011153)3.19523065
9Insulin-resistant diabetes mellitus (HP:0000831)3.17140784
10Visual hallucinations (HP:0002367)3.14482191
11Hyperinsulinemic hypoglycemia (HP:0000825)3.07634547
12Abnormality of the calf musculature (HP:0001430)3.04440564
13Papilledema (HP:0001085)3.00882868
14Difficulty running (HP:0009046)2.96577873
15Pheochromocytoma (HP:0002666)2.90061316
16Muscle fiber splitting (HP:0003555)2.89467562
17Bundle branch block (HP:0011710)2.84112290
18Atonic seizures (HP:0010819)2.83274184
19Agitation (HP:0000713)2.80602768
20Arterial tortuosity (HP:0005116)2.77538515
21Heart block (HP:0012722)2.73839351
22Hyperglycemia (HP:0003074)2.72549787
23Papillary thyroid carcinoma (HP:0002895)2.69933565
24Prolonged QT interval (HP:0001657)2.64791297
25Ventricular fibrillation (HP:0001663)2.62623498
26Syncope (HP:0001279)2.60364670
27Myotonia (HP:0002486)2.58036756
28Focal seizures (HP:0007359)2.58035282
29Myoglobinuria (HP:0002913)2.57822566
30Muscle fiber inclusion bodies (HP:0100299)2.53138990
31Hyperventilation (HP:0002883)2.52953578
32Vascular tortuosity (HP:0004948)2.52920911
33EMG: myopathic abnormalities (HP:0003458)2.48510291
34Ventricular tachycardia (HP:0004756)2.47491755
35Neuroendocrine neoplasm (HP:0100634)2.46575106
36Increased variability in muscle fiber diameter (HP:0003557)2.46481673
37Type 1 muscle fiber predominance (HP:0003803)2.44979632
38Atrial fibrillation (HP:0005110)2.41293338
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.41250117
40EMG: neuropathic changes (HP:0003445)2.40324945
41Absence seizures (HP:0002121)2.40016343
42Atrioventricular block (HP:0001678)2.38739296
43Primary atrial arrhythmia (HP:0001692)2.32448840
44Frequent falls (HP:0002359)2.32069624
45Large for gestational age (HP:0001520)2.30550515
46Action tremor (HP:0002345)2.29737575
47Right ventricular cardiomyopathy (HP:0011663)2.28959573
48Ketoacidosis (HP:0001993)2.28427146
49Abnormality of calcium-phosphate metabolism (HP:0100530)2.26964290
50Increased connective tissue (HP:0009025)2.26954531
51Termporal pattern (HP:0011008)2.26615411
52Insidious onset (HP:0003587)2.26615411
53Areflexia of lower limbs (HP:0002522)2.25709660
54Dysmetric saccades (HP:0000641)2.21166928
55Mildly elevated creatine phosphokinase (HP:0008180)2.16828647
56Vertebral arch anomaly (HP:0008438)2.16826092
57Lipoatrophy (HP:0100578)2.16634966
58Genetic anticipation (HP:0003743)2.16364792
59Hypoplastic ischia (HP:0003175)2.10808114
60Difficulty climbing stairs (HP:0003551)2.10650946
61Abnormality of skeletal muscle fiber size (HP:0012084)2.10414932
62Supraventricular tachycardia (HP:0004755)2.09877384
63Hypoglycemic seizures (HP:0002173)2.08923790
64Supraventricular arrhythmia (HP:0005115)2.08112504
65Hypoglycemic coma (HP:0001325)2.07134773
66Dialeptic seizures (HP:0011146)2.06256490
67Proximal amyotrophy (HP:0007126)2.05811612
68Hemiparesis (HP:0001269)2.04596248
69Fetal akinesia sequence (HP:0001989)2.04166266
70Hypercortisolism (HP:0001578)2.03744974
71Widely spaced teeth (HP:0000687)2.03669590
72Blue irides (HP:0000635)2.02862465
73Asymmetric septal hypertrophy (HP:0001670)2.02597792
74Cubitus valgus (HP:0002967)2.02582842
75Hemiplegia (HP:0002301)2.02255806
76Nemaline bodies (HP:0003798)2.01989475
77Generalized tonic-clonic seizures (HP:0002069)2.01983819
78Peritonitis (HP:0002586)2.01793749
79Truncal obesity (HP:0001956)2.01357685
80Epileptic encephalopathy (HP:0200134)1.98687461
81Macroorchidism (HP:0000053)1.98575452
82Abnormality of the left ventricular outflow tract (HP:0011103)1.98487049
83Subaortic stenosis (HP:0001682)1.98487049
84Hamartoma of the eye (HP:0010568)1.94770597
85Left ventricular hypertrophy (HP:0001712)1.94603415
86Asymmetry of the thorax (HP:0001555)1.94587039
87Symptomatic seizures (HP:0011145)1.94314210
88Abnormality of the ischium (HP:0003174)1.93708553
89Ventricular arrhythmia (HP:0004308)1.91589158
90Hypokalemia (HP:0002900)1.91475003
91Abnormality of the right ventricle (HP:0001707)1.90954773
92Gaze-evoked nystagmus (HP:0000640)1.90450524
93Abnormal EKG (HP:0003115)1.89654000
94Neck muscle weakness (HP:0000467)1.89653553
95Postural tremor (HP:0002174)1.89222280
96Scapular winging (HP:0003691)1.87907579
97Truncal ataxia (HP:0002078)1.87422498
98Distal arthrogryposis (HP:0005684)1.87229833
99Myopathic facies (HP:0002058)1.87183928
100Thyroid carcinoma (HP:0002890)1.87067995
101Depression (HP:0000716)1.86124050
102Buphthalmos (HP:0000557)1.85802602
103Cystic hygroma (HP:0000476)1.84439377
104Drooling (HP:0002307)1.83612510
105Excessive salivation (HP:0003781)1.83612510
106Hyperkalemia (HP:0002153)1.83254479
107Conjunctival hamartoma (HP:0100780)1.82763271
108Fair hair (HP:0002286)1.82351807
109Rapidly progressive (HP:0003678)1.82270813
110Rimmed vacuoles (HP:0003805)1.81446265
111Lower limb amyotrophy (HP:0007210)1.81038878
112Megalencephaly (HP:0001355)1.80839466
113Congenital glaucoma (HP:0001087)1.80418511
114Supranuclear gaze palsy (HP:0000605)1.80355513
115Exotropia (HP:0000577)1.80172455
116Protruding tongue (HP:0010808)1.79477646
117Cerebral inclusion bodies (HP:0100314)1.78619973
118Progressive cerebellar ataxia (HP:0002073)1.78148913
119Anxiety (HP:0000739)1.77823076
120EEG with generalized epileptiform discharges (HP:0011198)1.77019053
121Broad-based gait (HP:0002136)1.76632967
122Ankle clonus (HP:0011448)1.76267278
123Gowers sign (HP:0003391)1.75373291
124Abnormal atrioventricular conduction (HP:0005150)1.75120574
125Abnormality of potassium homeostasis (HP:0011042)1.73022406
126Inappropriate behavior (HP:0000719)1.72935331
127Hypoplasia of the iris (HP:0007676)1.72875356
128Epileptiform EEG discharges (HP:0011182)1.72459275
129Hypsarrhythmia (HP:0002521)1.71971632
130Neoplasm of the peripheral nervous system (HP:0100007)1.71863497
131Bradycardia (HP:0001662)1.71376698
132Curly hair (HP:0002212)1.71251448
133Febrile seizures (HP:0002373)1.71185545
134Round ear (HP:0100830)1.69462285
135Neurofibrillary tangles (HP:0002185)1.69097094
136Steppage gait (HP:0003376)1.68705867
137Wide anterior fontanel (HP:0000260)1.68668671
138Dilated cardiomyopathy (HP:0001644)1.67331904
139Calcaneovalgus deformity (HP:0001848)1.66231373
140Arthropathy (HP:0003040)1.65341657
141Limited hip movement (HP:0008800)1.64644917
142Pulmonic stenosis (HP:0001642)1.62742330
143Overgrowth (HP:0001548)1.60362757
144Neonatal short-limb short stature (HP:0008921)1.60097693
145Volvulus (HP:0002580)1.58717955
146Dysdiadochokinesis (HP:0002075)1.58669879
147Absent frontal sinuses (HP:0002688)1.57830362
148Muscular dystrophy (HP:0003560)1.57607610
149Mitral valve prolapse (HP:0001634)1.56389493
150Exostoses (HP:0100777)1.55407841
151Urinary bladder sphincter dysfunction (HP:0002839)1.53363827
152Menstrual irregularities (HP:0000858)1.53210551
153Long nose (HP:0003189)1.51717957
154Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.49970883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.06419906
2NTRK32.73867745
3MAP3K22.72070842
4INSRR2.55113250
5PHKG22.51426185
6PHKG12.51426185
7MARK12.41368358
8PRKD32.40839176
9MAP3K92.31853201
10TTN2.31730414
11MAP3K42.10800862
12NTRK12.06005962
13OBSCN2.00782153
14TRIB31.84876293
15FRK1.84660011
16MAP3K131.75324213
17DMPK1.75201563
18CAMKK21.74662288
19KSR21.72489392
20WNK41.63103668
21PAK31.60266811
22PDGFRA1.57124908
23PAK61.47587331
24SGK21.41597249
25FER1.40751461
26STK38L1.39765321
27RET1.39627519
28MAP2K41.37638911
29HIPK21.37311926
30MINK11.35681973
31MOS1.35123762
32UHMK11.31749822
33WNK11.28889529
34BMPR1B1.24507848
35YES11.23438271
36LATS11.22961689
37TIE11.21348425
38MAP3K71.19734571
39PDK31.19646377
40PDK41.19646377
41MAP3K11.18643104
42ACVR1B1.17273370
43PRKCH1.16916139
44LATS21.15327452
45SCYL21.15130883
46MAP2K71.12476790
47CAMKK11.11841025
48GRK51.10899257
49NTRK21.07193304
50NEK91.06266935
51CDK51.04587598
52CDC42BPA1.04187966
53LMTK21.03962404
54SIK20.99943920
55PRKCE0.99351927
56MKNK20.97047860
57EPHA40.96049997
58ERBB30.93496596
59RIPK10.92388869
60CAMK2D0.92304457
61CAMK1G0.92106399
62DAPK20.91558575
63PIK3CA0.90953093
64PLK20.90488213
65PRKD10.89855181
66FGFR20.89241566
67CAMK2A0.87873808
68BRD40.84051972
69STK110.84045921
70AKT30.82936185
71PINK10.75283367
72CASK0.75126330
73PKN20.74288176
74PRKAA10.73161034
75PDK20.71063447
76PNCK0.70051767
77STK30.69729900
78MAP2K10.67069021
79DDR20.65904148
80STK390.65695906
81SGK10.65616406
82SGK2230.65513885
83SGK4940.65513885
84STK240.65500948
85MAPK130.65267282
86STK380.65259828
87PRKAA20.64915289
88KSR10.63283594
89TAOK30.63222917
90EPHB20.62656775
91BCR0.61855544
92LIMK10.61474301
93TAOK10.60934043
94PDPK10.60312608
95JAK10.60250236
96MAP3K140.59914970
97PTK20.59752457
98NLK0.58153232
99PTK60.57657823
100PDGFRB0.57336603
101FGFR30.55481239
102MAP2K60.55369697
103MAP3K60.55059170
104CAMK2B0.54618198
105WNK30.53889324
106TYRO30.53481531
107ROCK10.53409552
108MAPKAPK30.52967489
109MARK20.52810931
110CAMK40.52773474
111RPS6KB10.51933004
112CAMK10.51727661
113CSNK1G20.51586959
114TRPM70.51055398
115PKN10.50098468
116MAPK120.49675498
117RPS6KA20.49652139
118EPHA30.49169013
119ROCK20.48411447
120MAPK100.47934457
121SGK30.47925738
122BRSK20.47607009
123MAPK70.46812021
124ALK0.46195722
125CDK120.46194858
126MUSK0.45567272
127PDK10.45198850
128MET0.45118628
129PIK3CG0.44420695
130GRK70.44162548
131PRKCG0.44117244
132RPS6KA40.42924858
133FES0.41528657
134MELK0.41371613
135PTK2B0.39916066
136DYRK1A0.37705349
137CDK30.35841899

Predicted pathways (KEGG)

RankGene SetZ-score
1Insulin secretion_Homo sapiens_hsa049112.36795837
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.02951914
3Long-term potentiation_Homo sapiens_hsa047201.83462597
4Type II diabetes mellitus_Homo sapiens_hsa049301.82875688
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81714012
6Synaptic vesicle cycle_Homo sapiens_hsa047211.80794560
7Dilated cardiomyopathy_Homo sapiens_hsa054141.78532698
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76389604
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75062739
10Circadian entrainment_Homo sapiens_hsa047131.72820686
11GABAergic synapse_Homo sapiens_hsa047271.68780159
12Amphetamine addiction_Homo sapiens_hsa050311.61587352
13Cardiac muscle contraction_Homo sapiens_hsa042601.58253770
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57650641
15Dopaminergic synapse_Homo sapiens_hsa047281.56835012
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56689899
17Renin secretion_Homo sapiens_hsa049241.56203104
18Cholinergic synapse_Homo sapiens_hsa047251.51652785
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51256564
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46048417
21Gastric acid secretion_Homo sapiens_hsa049711.42243027
22Morphine addiction_Homo sapiens_hsa050321.41210304
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38804086
24Glutamatergic synapse_Homo sapiens_hsa047241.38551405
25Dorso-ventral axis formation_Homo sapiens_hsa043201.37756075
26Oxytocin signaling pathway_Homo sapiens_hsa049211.37346789
27Cocaine addiction_Homo sapiens_hsa050301.37074201
28Taste transduction_Homo sapiens_hsa047421.33328447
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32151366
30Salivary secretion_Homo sapiens_hsa049701.30903152
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30508164
32GnRH signaling pathway_Homo sapiens_hsa049121.29394224
33Serotonergic synapse_Homo sapiens_hsa047261.29380918
34Long-term depression_Homo sapiens_hsa047301.29256553
35Nicotine addiction_Homo sapiens_hsa050331.28705022
36Estrogen signaling pathway_Homo sapiens_hsa049151.23486562
37Olfactory transduction_Homo sapiens_hsa047401.21595002
38Vibrio cholerae infection_Homo sapiens_hsa051101.20741143
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17452292
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.13819898
41Gap junction_Homo sapiens_hsa045401.13809260
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07921711
43Pancreatic secretion_Homo sapiens_hsa049721.07435780
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06318460
45Glucagon signaling pathway_Homo sapiens_hsa049221.06216149
46Collecting duct acid secretion_Homo sapiens_hsa049661.04976762
47Calcium signaling pathway_Homo sapiens_hsa040201.03075900
48cAMP signaling pathway_Homo sapiens_hsa040241.02951111
49Type I diabetes mellitus_Homo sapiens_hsa049401.02378253
50Renal cell carcinoma_Homo sapiens_hsa052111.01609826
51FoxO signaling pathway_Homo sapiens_hsa040680.99938247
52Glioma_Homo sapiens_hsa052140.99358371
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99094576
54Melanogenesis_Homo sapiens_hsa049160.97794145
55Circadian rhythm_Homo sapiens_hsa047100.96003445
56Insulin signaling pathway_Homo sapiens_hsa049100.95144384
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92990430
58Insulin resistance_Homo sapiens_hsa049310.90635033
59mTOR signaling pathway_Homo sapiens_hsa041500.87691960
60Thyroid hormone synthesis_Homo sapiens_hsa049180.86331564
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84218237
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84063449
63Axon guidance_Homo sapiens_hsa043600.81522354
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80623159
65Non-small cell lung cancer_Homo sapiens_hsa052230.80561598
66ABC transporters_Homo sapiens_hsa020100.79912542
67Chronic myeloid leukemia_Homo sapiens_hsa052200.79194408
68Alzheimers disease_Homo sapiens_hsa050100.78858091
69ErbB signaling pathway_Homo sapiens_hsa040120.77942900
70Pancreatic cancer_Homo sapiens_hsa052120.77531188
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76261887
72Focal adhesion_Homo sapiens_hsa045100.76228080
73VEGF signaling pathway_Homo sapiens_hsa043700.71540916
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71376223
75MAPK signaling pathway_Homo sapiens_hsa040100.71129910
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70213491
77AMPK signaling pathway_Homo sapiens_hsa041520.70187722
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66826766
79Prolactin signaling pathway_Homo sapiens_hsa049170.65317837
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.65115615
81Tight junction_Homo sapiens_hsa045300.64289603
82Ras signaling pathway_Homo sapiens_hsa040140.64226671
83Protein export_Homo sapiens_hsa030600.63935779
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63711471
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63166665
86Endometrial cancer_Homo sapiens_hsa052130.63078353
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62798327
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.61692837
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61473423
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.61354338
91Sulfur metabolism_Homo sapiens_hsa009200.60599029
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.60582008
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59949714
94Inositol phosphate metabolism_Homo sapiens_hsa005620.59261546
95Colorectal cancer_Homo sapiens_hsa052100.59213001
96Ovarian steroidogenesis_Homo sapiens_hsa049130.58810995
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.58472516
98T cell receptor signaling pathway_Homo sapiens_hsa046600.58455442
99TGF-beta signaling pathway_Homo sapiens_hsa043500.58442424
100Adherens junction_Homo sapiens_hsa045200.58070407
101Oxidative phosphorylation_Homo sapiens_hsa001900.57744895
102Proteoglycans in cancer_Homo sapiens_hsa052050.56629936
103Hippo signaling pathway_Homo sapiens_hsa043900.56480124
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55951865
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55279493
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55180488
107Amoebiasis_Homo sapiens_hsa051460.53939549
108Endocytosis_Homo sapiens_hsa041440.51756372
109Hedgehog signaling pathway_Homo sapiens_hsa043400.51708439
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50545213
111Rap1 signaling pathway_Homo sapiens_hsa040150.50483891
112Lysosome_Homo sapiens_hsa041420.49096273
113Choline metabolism in cancer_Homo sapiens_hsa052310.48459652
114ECM-receptor interaction_Homo sapiens_hsa045120.47534144
115Parkinsons disease_Homo sapiens_hsa050120.46083364
116Melanoma_Homo sapiens_hsa052180.44520973
117Platelet activation_Homo sapiens_hsa046110.44282380
118Wnt signaling pathway_Homo sapiens_hsa043100.43599988
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43385548

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