ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium movement (GO:0003341)	7.37219658
2	cilium or flagellum-dependent cell motility (GO:0001539)	7.19782955
3	epithelial cilium movement (GO:0003351)	6.58463464
4	axonemal dynein complex assembly (GO:0070286)	6.52165072
5	ventricular system development (GO:0021591)	5.73977475
6	axoneme assembly (GO:0035082)	5.32064120
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.24435482
8	motile cilium assembly (GO:0044458)	4.99006214
9	intraciliary transport (GO:0042073)	4.64214966
10	left/right axis specification (GO:0070986)	4.61239458
11	neural tube formation (GO:0001841)	3.66069598
12	* cilium organization (GO:0044782)	3.61307172
13	behavioral response to nicotine (GO:0035095)	3.60136882
14	response to auditory stimulus (GO:0010996)	3.53202989
15	* cilium assembly (GO:0042384)	3.49702221
16	positive regulation of interferon-alpha production (GO:0032727)	3.46409239
17	protein polyglutamylation (GO:0018095)	3.41374173
18	L-fucose catabolic process (GO:0042355)	3.36729075
19	fucose catabolic process (GO:0019317)	3.36729075
20	L-fucose metabolic process (GO:0042354)	3.36729075
21	regulation of activation of Janus kinase activity (GO:0010533)	3.34347203
22	positive regulation of cellular amide metabolic process (GO:0034250)	3.34094051
23	left/right pattern formation (GO:0060972)	3.31033281
24	protein localization to cilium (GO:0061512)	3.30071904
25	ganglion development (GO:0061548)	3.26718425
26	response to pheromone (GO:0019236)	3.26000482
27	microglial cell activation (GO:0001774)	3.20036892
28	smoothened signaling pathway (GO:0007224)	3.19575938
29	regulation of interferon-alpha production (GO:0032647)	3.19103359
30	* cilium morphogenesis (GO:0060271)	3.18899862
31	positive regulation by symbiont of host defense response (GO:0052509)	3.18137684
32	modulation by symbiont of host defense response (GO:0052031)	3.18137684
33	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	3.18137684
34	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	3.18137684
35	positive regulation by organism of defense response of other organism involved in symbiotic interact	3.18137684
36	modulation by symbiont of host immune response (GO:0052553)	3.18137684
37	doxorubicin metabolic process (GO:0044598)	3.17314138
38	daunorubicin metabolic process (GO:0044597)	3.17314138
39	polyketide metabolic process (GO:0030638)	3.17314138
40	natural killer cell mediated cytotoxicity (GO:0042267)	3.16176409
41	natural killer cell mediated immunity (GO:0002228)	3.16176409
42	sperm motility (GO:0030317)	3.14656824
43	auditory behavior (GO:0031223)	3.14638087
44	T-helper 1 type immune response (GO:0042088)	3.13335062
45	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.12634492
46	cellular response to type I interferon (GO:0071357)	3.12041023
47	type I interferon signaling pathway (GO:0060337)	3.12041023
48	startle response (GO:0001964)	3.10272426
49	platelet dense granule organization (GO:0060155)	3.10162627
50	response to type I interferon (GO:0034340)	3.08569343
51	regulation of mononuclear cell migration (GO:0071675)	3.08325902
52	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.08051190
53	centriole replication (GO:0007099)	3.07169010
54	determination of left/right symmetry (GO:0007368)	3.06382258
55	detection of molecule of bacterial origin (GO:0032490)	3.05803681
56	cellular response to interferon-alpha (GO:0035457)	3.02367737
57	intra-S DNA damage checkpoint (GO:0031573)	2.96018849
58	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.95882874
59	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.95601079
60	regulation of microtubule-based movement (GO:0060632)	2.94320354
61	determination of bilateral symmetry (GO:0009855)	2.93801034
62	response to peptidoglycan (GO:0032494)	2.89785905
63	specification of symmetry (GO:0009799)	2.86891240
64	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.86230514
65	mechanosensory behavior (GO:0007638)	2.84426544
66	production of molecular mediator involved in inflammatory response (GO:0002532)	2.84130404
67	regulation of cilium movement (GO:0003352)	2.81033440
68	piRNA metabolic process (GO:0034587)	2.80735622
69	microtubule depolymerization (GO:0007019)	2.80422181
70	somite development (GO:0061053)	2.80231813
71	nucleoside diphosphate phosphorylation (GO:0006165)	2.79164443
72	positive regulation of interleukin-12 production (GO:0032735)	2.76950011
73	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76732193
74	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.75516895
75	inner ear receptor stereocilium organization (GO:0060122)	2.71639444
76	replication fork processing (GO:0031297)	2.71205668
77	reciprocal DNA recombination (GO:0035825)	2.68383348
78	reciprocal meiotic recombination (GO:0007131)	2.68383348
79	centriole assembly (GO:0098534)	2.68075312
80	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.67594578
81	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.67594578
82	cellular response to exogenous dsRNA (GO:0071360)	2.65704084
83	multicellular organism reproduction (GO:0032504)	2.64294494
84	cornea development in camera-type eye (GO:0061303)	2.62745283
85	response to interferon-alpha (GO:0035455)	2.62229500
86	appendage development (GO:0048736)	2.61033893
87	limb development (GO:0060173)	2.61033893
88	macrophage activation (GO:0042116)	2.60830837
89	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.59548457
90	* cellular component assembly involved in morphogenesis (GO:0010927)	2.58917110
91	limb bud formation (GO:0060174)	2.58610871
92	acrosome reaction (GO:0007340)	2.58482818
93	synapsis (GO:0007129)	2.57745282
94	negative regulation of viral genome replication (GO:0045071)	2.56570659
95	gamma-aminobutyric acid transport (GO:0015812)	2.55360776
96	negative regulation of mast cell activation (GO:0033004)	2.53295662
97	GTP biosynthetic process (GO:0006183)	2.52380434
98	positive regulation of type 2 immune response (GO:0002830)	2.50683430
99	positive regulation of toll-like receptor signaling pathway (GO:0034123)	2.50582794
100	positive regulation of cAMP-mediated signaling (GO:0043950)	2.50235823
101	DNA double-strand break processing (GO:0000729)	2.49550215
102	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	2.49360930
103	behavioral response to ethanol (GO:0048149)	2.49199010
104	male meiosis (GO:0007140)	2.47966288
105	regulation of interferon-beta biosynthetic process (GO:0045357)	2.46419262
106	opioid receptor signaling pathway (GO:0038003)	2.45406234
107	neuron fate determination (GO:0048664)	2.45287541
108	spinal cord motor neuron differentiation (GO:0021522)	2.43596488
109	regulation of T-helper 1 cell differentiation (GO:0045625)	2.43382206
110	indole-containing compound catabolic process (GO:0042436)	2.42241498
111	indolalkylamine catabolic process (GO:0046218)	2.42241498
112	tryptophan catabolic process (GO:0006569)	2.42241498
113	neutrophil activation involved in immune response (GO:0002283)	2.41966958
114	water-soluble vitamin biosynthetic process (GO:0042364)	2.40272314
115	negative regulation of interleukin-17 production (GO:0032700)	2.40094429
116	head development (GO:0060322)	2.40023762
117	retinal ganglion cell axon guidance (GO:0031290)	2.38742343
118	retinal cone cell development (GO:0046549)	2.37372767
119	microtubule polymerization or depolymerization (GO:0031109)	2.37212384
120	reflex (GO:0060004)	2.36465501
121	regulation of macrophage chemotaxis (GO:0010758)	2.36096980
122	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.35741284
123	response to host immune response (GO:0052572)	2.35741284
124	indolalkylamine metabolic process (GO:0006586)	2.35371381
125	respiratory chain complex IV assembly (GO:0008535)	2.33707419
126	pyrimidine nucleobase catabolic process (GO:0006208)	2.33668110
127	retinal rod cell development (GO:0046548)	2.33248313
128	regulation of collateral sprouting (GO:0048670)	2.32903053
129	GPI anchor metabolic process (GO:0006505)	2.31538083
130	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.31209389
131	positive regulation of monocyte chemotaxis (GO:0090026)	2.31104294
132	photoreceptor cell maintenance (GO:0045494)	2.31082339
133	cellular ketone body metabolic process (GO:0046950)	2.30645429
134	olfactory bulb development (GO:0021772)	2.30549203
135	presynaptic membrane assembly (GO:0097105)	2.29763893
136	positive regulation of interleukin-17 production (GO:0032740)	2.29566942
137	embryonic epithelial tube formation (GO:0001838)	2.27865510
138	negative regulation of JUN kinase activity (GO:0043508)	2.27765647
139	cell differentiation in spinal cord (GO:0021515)	2.27559270
140	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.27432098
141	regulation of male gonad development (GO:2000018)	2.26858603
142	serotonin metabolic process (GO:0042428)	2.26774988
143	G-protein coupled receptor internalization (GO:0002031)	2.26257683
144	spermatid development (GO:0007286)	2.25411003
145	regulation of hexokinase activity (GO:1903299)	2.25259731
146	regulation of glucokinase activity (GO:0033131)	2.25259731
147	* organelle assembly (GO:0070925)	2.25234890
148	* cell projection assembly (GO:0030031)	2.24978105
149	rRNA catabolic process (GO:0016075)	2.24847876
150	photoreceptor cell development (GO:0042461)	2.24432622
151	detection of light stimulus involved in sensory perception (GO:0050962)	2.24415429
152	detection of light stimulus involved in visual perception (GO:0050908)	2.24415429
153	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.24353786
154	microtubule-based movement (GO:0007018)	2.23554142
155	dorsal/ventral pattern formation (GO:0009953)	2.23092886
156	C-terminal protein amino acid modification (GO:0018410)	2.23027954
157	recombinational repair (GO:0000725)	2.22901429
158	somite rostral/caudal axis specification (GO:0032525)	2.22894987
159	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.22678581
160	sensory perception of smell (GO:0007608)	2.22363526
161	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.22222221
162	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.22222221
163	NADH dehydrogenase complex assembly (GO:0010257)	2.22222221
164	double-strand break repair via homologous recombination (GO:0000724)	2.21005214
165	regulation of interleukin-17 production (GO:0032660)	2.20905436
166	nonmotile primary cilium assembly (GO:0035058)	2.19982074
167	positive regulation of natural killer cell differentiation (GO:0032825)	2.19471696
168	single fertilization (GO:0007338)	2.18865728
169	eye photoreceptor cell development (GO:0042462)	2.16650891
170	microtubule bundle formation (GO:0001578)	2.16162837
171	positive regulation of antigen processing and presentation (GO:0002579)	2.15939247
172	dentate gyrus development (GO:0021542)	2.14693579
173	protein K11-linked deubiquitination (GO:0035871)	2.14689802

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.50218229
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.29997084
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23882451
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.12080528
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.10535036
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.76275480
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.68891890
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.59882370
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.57379192
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.55088525
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.52574083
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.49702375
13	* IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.35127724
14	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.12957289
15	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.09589595
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.06886228
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01582846
18	P300_19829295_ChIP-Seq_ESCs_Human	1.94269839
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92306259
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89970573
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.84814391
22	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.83939854
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.82663773
24	FUS_26573619_Chip-Seq_HEK293_Human	1.82616990
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.82490484
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.80245649
27	RNF2_27304074_Chip-Seq_NSC_Mouse	1.79808841
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73931640
29	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.72288363
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70926590
31	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.70655424
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.68212030
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63246151
34	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.62749959
35	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.58852623
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57990271
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.57717549
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57405337
39	* IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.57254161
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.57230315
41	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.56273606
42	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.55797864
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.55422882
44	P53_22387025_ChIP-Seq_ESCs_Mouse	1.53633417
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.53250848
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52032406
47	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.51967220
48	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51349163
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51306141
50	VDR_22108803_ChIP-Seq_LS180_Human	1.51279144
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49253235
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49253235
53	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.48530044
54	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.47120332
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45561893
56	AR_25329375_ChIP-Seq_VCAP_Human	1.45333635
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.44653102
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44629068
59	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.44277474
60	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.43407404
61	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43280429
62	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.43181239
63	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.40790750
64	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.39988426
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39754419
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38315836
67	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.37564489
68	EWS_26573619_Chip-Seq_HEK293_Human	1.36773891
69	AR_21572438_ChIP-Seq_LNCaP_Human	1.36641499
70	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.35899155
71	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.32983484
72	* IRF8_27001747_Chip-Seq_BMDM_Mouse	1.32257608
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.31723478
74	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.31673092
75	* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31084286
76	PU1_27457419_Chip-Seq_LIVER_Mouse	1.30327323
77	ELK1_19687146_ChIP-ChIP_HELA_Human	1.30029567
78	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.29747615
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28752467
80	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.28592224
81	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.28572238
82	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.28398823
83	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.27505929
84	* STAT3_23295773_ChIP-Seq_U87_Human	1.26883866
85	* TP53_22573176_ChIP-Seq_HFKS_Human	1.25611921
86	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.25404629
87	P300_18555785_Chip-Seq_ESCs_Mouse	1.24349355
88	REST_21632747_ChIP-Seq_MESCs_Mouse	1.24335928
89	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.22298574
90	BCAT_22108803_ChIP-Seq_LS180_Human	1.22064998
91	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21713659
92	* TAL1_26923725_Chip-Seq_HPCs_Mouse	1.21245456
93	MYC_18940864_ChIP-ChIP_HL60_Human	1.20533053
94	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.20224952
95	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.19914841
96	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.19852147
97	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.19387970
98	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.19341448
99	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18792328
100	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18198982
101	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18198982
102	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17954030
103	TCF4_23295773_ChIP-Seq_U87_Human	1.17933923
104	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17525453
105	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.17517557
106	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.16536657
107	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16034387
108	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15428300
109	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.15218154
110	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.14994077
111	* ZFX_18555785_Chip-Seq_ESCs_Mouse	1.14796118
112	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14692960
113	TCF4_22108803_ChIP-Seq_LS180_Human	1.13482173
114	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.13165704
115	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.12500130
116	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11548157
117	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.11430019
118	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11059738
119	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.10891507
120	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.10064340
121	CBP_20019798_ChIP-Seq_JUKART_Human	1.09863727
122	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09863727
123	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.09521987
124	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09274845
125	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.08852190
126	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.07867395
127	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.07561822
128	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06252427
129	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05959664
130	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04898761
131	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04387843
132	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04387843
133	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03287316
134	CDX2_22108803_ChIP-Seq_LS180_Human	1.03136501
135	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.01908398
136	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00604347
137	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.99763446
138	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98526940
139	AR_20517297_ChIP-Seq_VCAP_Human	0.98016492
140	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97771744
141	TBL1_22424771_ChIP-Seq_293T_Human	0.97750297

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	6.03480956
2	MP0001984_abnormal_olfaction	3.08241031
3	MP0008004_abnormal_stomach_pH	2.92989287
4	MP0005646_abnormal_pituitary_gland	2.62246512
5	MP0002163_abnormal_gland_morphology	2.61568388
6	MP0001835_abnormal_antigen_presentation	2.46246106
7	MP0005410_abnormal_fertilization	2.43744472
8	MP0006072_abnormal_retinal_apoptosis	2.41636812
9	MP0008877_abnormal_DNA_methylation	2.37413581
10	MP0006292_abnormal_olfactory_placode	2.31965032
11	MP0000383_abnormal_hair_follicle	2.16257343
12	MP0005248_abnormal_Harderian_gland	2.15417162
13	MP0003787_abnormal_imprinting	2.08354632
14	MP0001346_abnormal_lacrimal_gland	2.07394945
15	MP0002638_abnormal_pupillary_reflex	2.05856052
16	MP0005379_endocrine/exocrine_gland_phen	2.02900957
17	MP0005645_abnormal_hypothalamus_physiol	2.01465671
18	MP0002736_abnormal_nociception_after	2.01157230
19	MP0001485_abnormal_pinna_reflex	2.00378818
20	MP0010386_abnormal_urinary_bladder	1.91400477
21	MP0000015_abnormal_ear_pigmentation	1.81526786
22	MP0001968_abnormal_touch/_nociception	1.80499771
23	MP0002938_white_spotting	1.80263398
24	MP0009785_altered_susceptibility_to	1.77505944
25	MP0006082_CNS_inflammation	1.76654160
26	MP0003122_maternal_imprinting	1.75243960
27	MP0004859_abnormal_synaptic_plasticity	1.72082090
28	MP0002837_dystrophic_cardiac_calcinosis	1.71826154
29	MP0002234_abnormal_pharynx_morphology	1.69051847
30	MP0008875_abnormal_xenobiotic_pharmacok	1.67028510
31	MP0003195_calcinosis	1.63042011
32	MP0002928_abnormal_bile_duct	1.62200390
33	MP0000427_abnormal_hair_cycle	1.56274576
34	MP0004043_abnormal_pH_regulation	1.53789159
35	MP0006276_abnormal_autonomic_nervous	1.50945664
36	MP0001440_abnormal_grooming_behavior	1.50689192
37	MP0003121_genomic_imprinting	1.50173081
38	MP0009046_muscle_twitch	1.49434317
39	MP0005174_abnormal_tail_pigmentation	1.49044978
40	MP0002148_abnormal_hypersensitivity_rea	1.45495832
41	MP0000778_abnormal_nervous_system	1.44352950
42	MP0004142_abnormal_muscle_tone	1.43419605
43	MP0003937_abnormal_limbs/digits/tail_de	1.43129491
44	MP0009780_abnormal_chondrocyte_physiolo	1.42910898
45	MP0002653_abnormal_ependyma_morphology	1.39034159
46	MP0002557_abnormal_social/conspecific_i	1.38633553
47	MP0010678_abnormal_skin_adnexa	1.38210984
48	MP0002277_abnormal_respiratory_mucosa	1.37680015
49	MP0001790_abnormal_immune_system	1.36664251
50	MP0005387_immune_system_phenotype	1.36664251
51	MP0001501_abnormal_sleep_pattern	1.35268141
52	MP0002572_abnormal_emotion/affect_behav	1.35199839
53	MP0000049_abnormal_middle_ear	1.34699877
54	MP0005551_abnormal_eye_electrophysiolog	1.32535314
55	MP0002233_abnormal_nose_morphology	1.31131899
56	MP0004510_myositis	1.29956916
57	MP0000372_irregular_coat_pigmentation	1.27179783
58	MP0009764_decreased_sensitivity_to	1.26254608
59	MP0005171_absent_coat_pigmentation	1.25296111
60	MP0002876_abnormal_thyroid_physiology	1.24361938
61	MP0008789_abnormal_olfactory_epithelium	1.23310553
62	MP0004885_abnormal_endolymph	1.21332378
63	MP0010030_abnormal_orbit_morphology	1.21190759
64	MP0003718_maternal_effect	1.20386840
65	MP0000647_abnormal_sebaceous_gland	1.20019936
66	MP0008995_early_reproductive_senescence	1.19658268
67	MP0002272_abnormal_nervous_system	1.19442677
68	MP0001502_abnormal_circadian_rhythm	1.19249828
69	MP0009697_abnormal_copulation	1.17295586
70	MP0004215_abnormal_myocardial_fiber	1.17191449
71	MP0005310_abnormal_salivary_gland	1.16913267
72	MP0004782_abnormal_surfactant_physiolog	1.16268598
73	MP0002063_abnormal_learning/memory/cond	1.14926831
74	MP0003045_fibrosis	1.14663250
75	MP0005195_abnormal_posterior_eye	1.12262526
76	MP0004742_abnormal_vestibular_system	1.12062279
77	MP0003724_increased_susceptibility_to	1.11812525
78	MP0009745_abnormal_behavioral_response	1.11722787
79	MP0005391_vision/eye_phenotype	1.10537487
80	MP0001529_abnormal_vocalization	1.09306588
81	MP0005623_abnormal_meninges_morphology	1.09137452
82	MP0003635_abnormal_synaptic_transmissio	1.09058674
83	MP0005000_abnormal_immune_tolerance	1.08801537
84	MP0002751_abnormal_autonomic_nervous	1.08436622
85	MP0003698_abnormal_male_reproductive	1.07716741
86	MP0003183_abnormal_peptide_metabolism	1.07166828
87	MP0002735_abnormal_chemical_nociception	1.07002119
88	MP0001986_abnormal_taste_sensitivity	1.06881391
89	MP0005394_taste/olfaction_phenotype	1.06338420
90	MP0005499_abnormal_olfactory_system	1.06338420
91	MP0001486_abnormal_startle_reflex	1.05099566
92	MP0001188_hyperpigmentation	1.05037173
93	MP0001324_abnormal_eye_pigmentation	1.04891277
94	MP0003880_abnormal_central_pattern	1.04843667
95	MP0000566_synostosis	1.04717170
96	MP0002419_abnormal_innate_immunity	1.04575031
97	MP0002184_abnormal_innervation	1.03451740
98	MP0004147_increased_porphyrin_level	1.02444039
99	MP0000685_abnormal_immune_system	0.99173201
100	MP0005367_renal/urinary_system_phenotyp	0.98844719
101	MP0000516_abnormal_urinary_system	0.98844719
102	MP0002752_abnormal_somatic_nervous	0.98596476
103	MP0008058_abnormal_DNA_repair	0.97302542
104	MP0003119_abnormal_digestive_system	0.96858124
105	MP0005253_abnormal_eye_physiology	0.96330035
106	MP0001963_abnormal_hearing_physiology	0.96164497
107	MP0003890_abnormal_embryonic-extraembry	0.94506882
108	MP0005187_abnormal_penis_morphology	0.94211961
109	MP0005025_abnormal_response_to	0.93643537
110	MP0000631_abnormal_neuroendocrine_gland	0.93048843
111	MP0003283_abnormal_digestive_organ	0.92256122
112	MP0008872_abnormal_physiological_respon	0.91144407
113	MP0005671_abnormal_response_to	0.90909267
114	MP0001286_abnormal_eye_development	0.90845136
115	MP0002067_abnormal_sensory_capabilities	0.89677927
116	MP0001293_anophthalmia	0.89178852
117	MP0002909_abnormal_adrenal_gland	0.88980119
118	MP0003943_abnormal_hepatobiliary_system	0.88360688
119	MP0002734_abnormal_mechanical_nocicepti	0.88085200
120	MP0002210_abnormal_sex_determination	0.87705558
121	MP0002282_abnormal_trachea_morphology	0.86907014
122	MP0001970_abnormal_pain_threshold	0.86232571
123	MP0005389_reproductive_system_phenotype	0.86177392
124	MP0003646_muscle_fatigue	0.85851001
125	MP0002064_seizures	0.85613718
126	MP0004133_heterotaxia	0.85565882
127	MP0003878_abnormal_ear_physiology	0.84645574
128	MP0005377_hearing/vestibular/ear_phenot	0.84645574
129	MP0003136_yellow_coat_color	0.84317211
130	MP0003011_delayed_dark_adaptation	0.83464845
131	MP0003879_abnormal_hair_cell	0.82274662
132	MP0005423_abnormal_somatic_nervous	0.81988067
133	MP0003938_abnormal_ear_development	0.81219622
134	MP0000653_abnormal_sex_gland	0.81002137
135	MP0005167_abnormal_blood-brain_barrier	0.80904633
136	MP0002452_abnormal_antigen_presenting	0.78112690
137	MP0002102_abnormal_ear_morphology	0.76542601
138	MP0003172_abnormal_lysosome_physiology	0.76228951
139	MP0001905_abnormal_dopamine_level	0.71307437
140	MP0000026_abnormal_inner_ear	0.69759623
141	MP0004924_abnormal_behavior	0.69757694
142	MP0005386_behavior/neurological_phenoty	0.69757694
143	MP0001929_abnormal_gametogenesis	0.69561942
144	MP0002160_abnormal_reproductive_system	0.69539500
145	MP0002693_abnormal_pancreas_physiology	0.69485206
146	MP0002723_abnormal_immune_serum	0.69111519
147	MP0004811_abnormal_neuron_physiology	0.68507716

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	7.25849272
2	Absent/shortened dynein arms (HP:0200106)	6.95684954
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.95684954
4	Rhinitis (HP:0012384)	6.69306418
5	Abnormal ciliary motility (HP:0012262)	5.83863609
6	Chronic bronchitis (HP:0004469)	5.70371910
7	Abnormal respiratory epithelium morphology (HP:0012253)	5.40016522
8	Abnormal respiratory motile cilium morphology (HP:0005938)	5.40016522
9	Nasal polyposis (HP:0100582)	3.54264038
10	Bronchiectasis (HP:0002110)	3.51541936
11	Medial flaring of the eyebrow (HP:0010747)	3.49747887
12	* True hermaphroditism (HP:0010459)	3.46276731
13	* Pancreatic fibrosis (HP:0100732)	3.37289650
14	Chronic sinusitis (HP:0011109)	3.26107162
15	Gait imbalance (HP:0002141)	3.05705236
16	Bronchitis (HP:0012387)	3.04064259
17	Congenital primary aphakia (HP:0007707)	3.03333968
18	Tubulointerstitial nephritis (HP:0001970)	2.94319620
19	* Chronic hepatic failure (HP:0100626)	2.90561221
20	Optic neuritis (HP:0100653)	2.87910748
21	Retrobulbar optic neuritis (HP:0100654)	2.87910748
22	Nephrogenic diabetes insipidus (HP:0009806)	2.81513480
23	Abnormality of the nasal mucosa (HP:0000433)	2.79226091
24	* Nephronophthisis (HP:0000090)	2.73165870
25	* Cystic liver disease (HP:0006706)	2.68587023
26	Increased IgM level (HP:0003496)	2.59793614
27	* Sclerocornea (HP:0000647)	2.55945003
28	* Pancreatic cysts (HP:0001737)	2.53494357
29	Orchitis (HP:0100796)	2.47443187
30	* Postaxial foot polydactyly (HP:0001830)	2.47364755
31	* Aplasia/Hypoplasia of the tongue (HP:0010295)	2.45470687
32	* Abnormality of the renal cortex (HP:0011035)	2.39310317
33	* Anencephaly (HP:0002323)	2.39310094
34	Genital tract atresia (HP:0001827)	2.36171480
35	Absent frontal sinuses (HP:0002688)	2.34017446
36	Poor coordination (HP:0002370)	2.32264163
37	Anophthalmia (HP:0000528)	2.28473897
38	* Congenital hepatic fibrosis (HP:0002612)	2.25447856
39	Abdominal situs inversus (HP:0003363)	2.23821307
40	Abnormality of abdominal situs (HP:0011620)	2.23821307
41	Absent eyebrow (HP:0002223)	2.23330167
42	Vaginal atresia (HP:0000148)	2.22215029
43	Type II lissencephaly (HP:0007260)	2.20977621
44	Abnormal hair whorl (HP:0010721)	2.18340839
45	* Abnormality of the renal medulla (HP:0100957)	2.18246217
46	Supernumerary spleens (HP:0009799)	2.12480677
47	Hip dysplasia (HP:0001385)	2.10866399
48	Recurrent abscess formation (HP:0002722)	2.09208442
49	Recurrent gram-negative bacterial infections (HP:0005420)	2.07576491
50	Abnormality of dentin (HP:0010299)	2.07399135
51	* Furrowed tongue (HP:0000221)	2.07321600
52	* Male pseudohermaphroditism (HP:0000037)	2.06409126
53	Aplasia/Hypoplasia of the lens (HP:0008063)	2.04593178
54	Hyperventilation (HP:0002883)	2.04568200
55	Tubulointerstitial abnormality (HP:0001969)	2.04154600
56	Chronic otitis media (HP:0000389)	2.04100367
57	Protruding tongue (HP:0010808)	2.03828492
58	Recurrent sinusitis (HP:0011108)	2.00412908
59	* Narrow forehead (HP:0000341)	2.00384713
60	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	10.1314848
61	* Oculomotor apraxia (HP:0000657)	1.98518866
62	Recurrent otitis media (HP:0000403)	1.95410684
63	Abnormality of the labia minora (HP:0012880)	1.95200873
64	Intestinal atresia (HP:0011100)	1.93532053
65	* Molar tooth sign on MRI (HP:0002419)	1.92208340
66	* Abnormality of midbrain morphology (HP:0002418)	1.92208340
67	Myositis (HP:0100614)	1.91622010
68	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.91588999
69	Dyschromatopsia (HP:0007641)	1.88984666
70	* Occipital encephalocele (HP:0002085)	1.88755280
71	* Postaxial hand polydactyly (HP:0001162)	1.87608255
72	Optic nerve hypoplasia (HP:0000609)	1.86742280
73	Volvulus (HP:0002580)	1.86516991
74	Bell-shaped thorax (HP:0001591)	1.84291756
75	Median cleft lip (HP:0000161)	1.80188581
76	Rib fusion (HP:0000902)	1.79384390
77	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.79357629
78	Hyperglycinemia (HP:0002154)	1.78285147
79	Abnormal rod and cone electroretinograms (HP:0008323)	1.78012311
80	Decreased central vision (HP:0007663)	1.77504081
81	* Abnormal drinking behavior (HP:0030082)	1.77280222
82	* Polydipsia (HP:0001959)	1.77280222
83	Increased corneal curvature (HP:0100692)	1.77269570
84	Keratoconus (HP:0000563)	1.77269570
85	Progressive cerebellar ataxia (HP:0002073)	1.76681813
86	Febrile seizures (HP:0002373)	1.76620135
87	Genetic anticipation (HP:0003743)	1.76599937
88	* Aganglionic megacolon (HP:0002251)	1.75976265
89	Hypochromic microcytic anemia (HP:0004840)	1.75147596
90	Congenital stationary night blindness (HP:0007642)	1.75115745
91	Midline defect of the nose (HP:0004122)	1.74999791
92	* Prominent nasal bridge (HP:0000426)	1.74910199
93	Hyperglycinuria (HP:0003108)	1.74451440
94	Broad foot (HP:0001769)	1.74303549
95	Attenuation of retinal blood vessels (HP:0007843)	1.74147092
96	Porencephaly (HP:0002132)	1.73105552
97	Focal motor seizures (HP:0011153)	1.72477226
98	Large for gestational age (HP:0001520)	1.71922056
99	Specific learning disability (HP:0001328)	1.71397416
100	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.68931599
101	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.67745988
102	Congenital sensorineural hearing impairment (HP:0008527)	1.65345553
103	* Multicystic kidney dysplasia (HP:0000003)	1.64927412
104	Acute encephalopathy (HP:0006846)	1.63618079
105	Cerebellar dysplasia (HP:0007033)	1.63602105
106	* Dandy-Walker malformation (HP:0001305)	1.63356262
107	* Highly arched eyebrow (HP:0002553)	1.62899000
108	Renal cortical cysts (HP:0000803)	1.62652652
109	Retinitis pigmentosa (HP:0000510)	1.62349395
110	Astigmatism (HP:0000483)	1.62259412
111	Gastrointestinal atresia (HP:0002589)	1.62152997
112	Infertility (HP:0000789)	1.61820356
113	Recurrent bacterial skin infections (HP:0005406)	1.60844265
114	Recurrent pneumonia (HP:0006532)	1.60520337
115	Acute necrotizing encephalopathy (HP:0006965)	1.59260427
116	Short tibia (HP:0005736)	1.58734876
117	Abnormality of macular pigmentation (HP:0008002)	1.58531586
118	* Preaxial hand polydactyly (HP:0001177)	1.58216243
119	Left ventricular hypertrophy (HP:0001712)	1.58115561
120	Asplenia (HP:0001746)	1.57736204
121	Pendular nystagmus (HP:0012043)	1.56087904
122	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.56058746
123	Abolished electroretinogram (ERG) (HP:0000550)	1.55907865
124	Basal ganglia calcification (HP:0002135)	1.55907167
125	Bony spicule pigmentary retinopathy (HP:0007737)	1.55426136
126	Gaze-evoked nystagmus (HP:0000640)	1.55279647
127	Decreased testicular size (HP:0008734)	1.55167859
128	Eczematoid dermatitis (HP:0000976)	1.54351089
129	Abnormality of permanent molar morphology (HP:0011071)	1.53701923
130	Abnormality of the dental root (HP:0006486)	1.53701923
131	Taurodontia (HP:0000679)	1.53701923
132	Mitochondrial inheritance (HP:0001427)	1.53492671
133	Increased hepatocellular lipid droplets (HP:0006565)	1.52220125
134	Short nail (HP:0001799)	1.51818423
135	Abnormality of DNA repair (HP:0003254)	1.51805431
136	Hemiparesis (HP:0001269)	1.51697416
137	Colon cancer (HP:0003003)	1.51573534
138	Cutaneous finger syndactyly (HP:0010554)	1.51314921
139	* Tubular atrophy (HP:0000092)	1.50993649
140	Abnormality of molar (HP:0011077)	1.50041265
141	Abnormality of molar morphology (HP:0011070)	1.50041265
142	Fibular hypoplasia (HP:0003038)	1.49197157
143	Renal hypoplasia (HP:0000089)	1.47819624
144	Bifid tongue (HP:0010297)	1.47146288
145	Microglossia (HP:0000171)	1.46877937
146	Abnormality of the frontal sinuses (HP:0002687)	1.46837693
147	Gingivitis (HP:0000230)	1.46758673
148	Cleft eyelid (HP:0000625)	1.46554570
149	Central scotoma (HP:0000603)	1.46440699
150	Mediastinal lymphadenopathy (HP:0100721)	1.45787986
151	Subacute progressive viral hepatitis (HP:0006572)	1.45213169

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.43949189
2	SIK3	3.80776535
3	IRAK3	3.08228109
4	MAPK15	3.00158323
5	MAP3K14	2.99177348
6	MAP4K2	2.93056495
7	IRAK4	2.58834777
8	WNK4	2.18707345
9	CASK	2.07183200
10	BMPR1B	1.93996572
11	SIK2	1.92868758
12	BMPR2	1.90102700
13	TNIK	1.86357439
14	PINK1	1.85890097
15	NTRK2	1.85692216
16	TRIM28	1.84088571
17	BCR	1.82611287
18	YES1	1.80511479
19	INSRR	1.80375672
20	IRAK1	1.78983473
21	STK39	1.75085455
22	BRSK2	1.72631977
23	NUAK1	1.72581172
24	MAP2K7	1.71765608
25	GRK1	1.69974627
26	PLK2	1.68267200
27	ERBB3	1.67982721
28	MKNK1	1.61207101
29	ACVR1B	1.58679863
30	IRAK2	1.58169921
31	IKBKE	1.57708427
32	AKT3	1.48998997
33	LATS1	1.48965811
34	SGK2	1.48053785
35	ADRBK2	1.44816296
36	TBK1	1.43955798
37	TYK2	1.42848101
38	NTRK3	1.41760504
39	TLK1	1.41377707
40	RIPK4	1.40361887
41	CAMKK2	1.37851136
42	SIK1	1.36269100
43	PBK	1.32679280
44	ZAK	1.32291606
45	JAK1	1.27417799
46	CDK3	1.24939743
47	PTK2B	1.23955263
48	MAP3K12	1.23079137
49	WEE1	1.21031184
50	MAPK13	1.18871925
51	PAK3	1.18492426
52	WNK3	1.17026604
53	FGFR2	1.11383044
54	PLK4	1.09394007
55	CHUK	1.06617842
56	OXSR1	1.06417885
57	BCKDK	1.05963103
58	KIT	1.04977115
59	TXK	1.04778231
60	JAK3	1.03663007
61	PNCK	1.00839688
62	NLK	0.98216895
63	CSNK1G1	0.96799352
64	EIF2AK2	0.96506608
65	PRPF4B	0.94579679
66	IKBKB	0.92524418
67	STK3	0.90615336
68	EPHA3	0.89717369
69	TGFBR1	0.89060115
70	DYRK2	0.88122674
71	DYRK3	0.87897492
72	MAP3K4	0.87494447
73	CDK8	0.86859950
74	CSNK1G2	0.86648470
75	PLK3	0.86568479
76	SGK223	0.86036140
77	SGK494	0.86036140
78	MARK3	0.79345506
79	MARK1	0.77358726
80	CSNK1G3	0.76199547
81	SGK3	0.76100374
82	EIF2AK3	0.75493274
83	ADRBK1	0.73886295
84	PLK1	0.72624464
85	CSNK1A1L	0.72282095
86	PRKCE	0.71466263
87	SRPK1	0.71241762
88	TEC	0.70528557
89	BRD4	0.69059863
90	EPHA4	0.68859540
91	PRKCG	0.68287133
92	MET	0.66253311
93	STK38L	0.65689605
94	ABL1	0.63668030
95	CAMKK1	0.62024610
96	PRKCQ	0.61883476
97	NEK9	0.61146817
98	TIE1	0.60468673
99	GRK7	0.60382021
100	VRK2	0.59647340
101	NME1	0.58027549
102	STK16	0.57935538
103	PRKCH	0.56318444
104	PKN1	0.56075601
105	FER	0.54985649
106	TTK	0.54785435
107	MAP3K13	0.54581041
108	CDK19	0.54324554
109	PASK	0.54157933
110	SYK	0.52158022
111	BRAF	0.51797241
112	TAOK3	0.51347725
113	DYRK1A	0.50571432
114	MUSK	0.49945018
115	VRK1	0.49490305
116	CAMK2A	0.47950445
117	EGFR	0.47553215
118	ATR	0.47272044
119	GRK5	0.45696680
120	TSSK6	0.44635426
121	PIM2	0.44435457
122	CAMK1G	0.44199782
123	DYRK1B	0.43921824
124	TRPM7	0.42716710
125	OBSCN	0.42201978
126	ATM	0.41556308
127	PRKACA	0.41480024
128	ERBB2	0.39811692
129	CSNK1A1	0.39645670
130	FES	0.39579685
131	RPS6KA2	0.39168873
132	RPS6KA5	0.38815114
133	EPHB2	0.38259786
134	RPS6KA4	0.37435869
135	PRKAA1	0.36346060
136	PRKCI	0.35851152
137	BTK	0.35451958
138	CHEK2	0.35237851
139	MAPKAPK5	0.34084899
140	SGK1	0.34065497
141	FGFR1	0.34031613
142	MINK1	0.33999794
143	PHKG2	0.33966931
144	PHKG1	0.33966931
145	CCNB1	0.33825902
146	DAPK2	0.33632481
147	PIK3CA	0.33471631
148	MAP2K4	0.33300527
149	IGF1R	0.31283452
150	CAMK1D	0.31089050
151	HCK	0.30924743
152	MST4	0.30760067
153	PDK3	0.29686383
154	PDK4	0.29686383
155	MKNK2	0.29515032

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.70875016
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.66479801
3	Protein export_Homo sapiens_hsa03060	2.39396236
4	Propanoate metabolism_Homo sapiens_hsa00640	2.37713693
5	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	2.37179447
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.24607454
7	Butanoate metabolism_Homo sapiens_hsa00650	2.23719410
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.23257484
9	Olfactory transduction_Homo sapiens_hsa04740	2.16616238
10	Phototransduction_Homo sapiens_hsa04744	2.16422233
11	Allograft rejection_Homo sapiens_hsa05330	2.15652011
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.02992062
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.00091903
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.93944611
15	Basal transcription factors_Homo sapiens_hsa03022	1.92777761
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.92633191
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.91886537
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.89953574
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.89250939
20	Huntingtons disease_Homo sapiens_hsa05016	1.88442793
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.83721532
22	Nicotine addiction_Homo sapiens_hsa05033	1.83643180
23	Leishmaniasis_Homo sapiens_hsa05140	1.75662885
24	Measles_Homo sapiens_hsa05162	1.70238204
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.69649051
26	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.69490583
27	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.66306776
28	Homologous recombination_Homo sapiens_hsa03440	1.63512723
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.63356321
30	RNA polymerase_Homo sapiens_hsa03020	1.63174928
31	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.63111723
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.60894045
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.58616304
34	Morphine addiction_Homo sapiens_hsa05032	1.56743485
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.55112494
36	One carbon pool by folate_Homo sapiens_hsa00670	1.54587793
37	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.53677643
38	Parkinsons disease_Homo sapiens_hsa05012	1.52042259
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.47199132
40	Legionellosis_Homo sapiens_hsa05134	1.44101187
41	Caffeine metabolism_Homo sapiens_hsa00232	1.43730386
42	Influenza A_Homo sapiens_hsa05164	1.43706344
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.42764632
44	African trypanosomiasis_Homo sapiens_hsa05143	1.42639425
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.41333994
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.40944301
47	Tryptophan metabolism_Homo sapiens_hsa00380	1.38274479
48	Chemical carcinogenesis_Homo sapiens_hsa05204	1.38255885
49	Peroxisome_Homo sapiens_hsa04146	1.36282544
50	Pertussis_Homo sapiens_hsa05133	1.33973424
51	RNA degradation_Homo sapiens_hsa03018	1.33763771
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33286306
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.33269039
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.32663023
55	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.31689499
56	Steroid biosynthesis_Homo sapiens_hsa00100	1.31205338
57	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.29164791
58	Circadian entrainment_Homo sapiens_hsa04713	1.28578377
59	Serotonergic synapse_Homo sapiens_hsa04726	1.27475867
60	TNF signaling pathway_Homo sapiens_hsa04668	1.23432220
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.22773466
62	Regulation of autophagy_Homo sapiens_hsa04140	1.20310156
63	Tuberculosis_Homo sapiens_hsa05152	1.19659922
64	ABC transporters_Homo sapiens_hsa02010	1.19256812
65	GABAergic synapse_Homo sapiens_hsa04727	1.18749108
66	Collecting duct acid secretion_Homo sapiens_hsa04966	1.16136248
67	Phagosome_Homo sapiens_hsa04145	1.15226503
68	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13979437
69	Cardiac muscle contraction_Homo sapiens_hsa04260	1.13749253
70	Chemokine signaling pathway_Homo sapiens_hsa04062	1.13059932
71	Malaria_Homo sapiens_hsa05144	1.12987165
72	Herpes simplex infection_Homo sapiens_hsa05168	1.10682292
73	Glutamatergic synapse_Homo sapiens_hsa04724	1.10372810
74	Osteoclast differentiation_Homo sapiens_hsa04380	1.08635638
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.08425955
76	Insulin secretion_Homo sapiens_hsa04911	1.04266333
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02269042
78	Taste transduction_Homo sapiens_hsa04742	1.01042402
79	Retinol metabolism_Homo sapiens_hsa00830	0.99763419
80	Salmonella infection_Homo sapiens_hsa05132	0.99026148
81	Amphetamine addiction_Homo sapiens_hsa05031	0.95256162
82	Alzheimers disease_Homo sapiens_hsa05010	0.94944782
83	Toxoplasmosis_Homo sapiens_hsa05145	0.94257485
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94250469
85	Hepatitis B_Homo sapiens_hsa05161	0.93397974
86	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.92695993
87	Cholinergic synapse_Homo sapiens_hsa04725	0.92311981
88	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.91828077
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91733630
90	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.90038131
91	Type II diabetes mellitus_Homo sapiens_hsa04930	0.85805038
92	Histidine metabolism_Homo sapiens_hsa00340	0.85473712
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84879526
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.84279903
95	Vibrio cholerae infection_Homo sapiens_hsa05110	0.82669131
96	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.82608918
97	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.81861442
98	Purine metabolism_Homo sapiens_hsa00230	0.81616787
99	Asthma_Homo sapiens_hsa05310	0.80426386
100	Circadian rhythm_Homo sapiens_hsa04710	0.79879478
101	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.78764309
102	Cocaine addiction_Homo sapiens_hsa05030	0.78747846
103	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78458995
104	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.77228240
105	Dopaminergic synapse_Homo sapiens_hsa04728	0.77032806
106	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77001632
107	Fatty acid degradation_Homo sapiens_hsa00071	0.76434566
108	Metabolic pathways_Homo sapiens_hsa01100	0.76069028
109	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.75720548
110	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.74786419
111	Hippo signaling pathway_Homo sapiens_hsa04390	0.73610176
112	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.72845409
113	Prolactin signaling pathway_Homo sapiens_hsa04917	0.72810515
114	Fatty acid metabolism_Homo sapiens_hsa01212	0.72077711
115	cAMP signaling pathway_Homo sapiens_hsa04024	0.72034579
116	Renin secretion_Homo sapiens_hsa04924	0.71885390
117	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71697176
118	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71033297
119	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69249754
120	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.69135786
121	ErbB signaling pathway_Homo sapiens_hsa04012	0.67647128
122	Long-term potentiation_Homo sapiens_hsa04720	0.67489009
123	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.65131029
124	Prion diseases_Homo sapiens_hsa05020	0.64719181
125	RNA transport_Homo sapiens_hsa03013	0.64684518
126	Nucleotide excision repair_Homo sapiens_hsa03420	0.63214848
127	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.62539022
128	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.62068493
129	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61604719
130	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61457227
131	Basal cell carcinoma_Homo sapiens_hsa05217	0.59534125
132	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59443676
133	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58292944
134	Hepatitis C_Homo sapiens_hsa05160	0.57086434
135	Axon guidance_Homo sapiens_hsa04360	0.57063509
136	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.57033660
137	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.56329512
138	Fatty acid elongation_Homo sapiens_hsa00062	0.56233130
139	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.56111205
140	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55692777
141	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.55401997
142	Alcoholism_Homo sapiens_hsa05034	0.55318059
143	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.55030504
144	Glutathione metabolism_Homo sapiens_hsa00480	0.54895582
145	Mismatch repair_Homo sapiens_hsa03430	0.54576907
146	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.53711039
147	Estrogen signaling pathway_Homo sapiens_hsa04915	0.51428150
148	Antigen processing and presentation_Homo sapiens_hsa04612	0.50529624
149	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.50216339
150	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50204009
151	Ras signaling pathway_Homo sapiens_hsa04014	0.50025717
152	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.49637893
153	Sphingolipid metabolism_Homo sapiens_hsa00600	0.48013089
154	Apoptosis_Homo sapiens_hsa04210	0.47957592
155	Pyrimidine metabolism_Homo sapiens_hsa00240	0.47073256
156	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46257189
157	Tyrosine metabolism_Homo sapiens_hsa00350	0.45450164
158	Melanogenesis_Homo sapiens_hsa04916	0.44949865
159	Salivary secretion_Homo sapiens_hsa04970	0.44589708
160	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.44554313
161	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44525932
162	Lysine degradation_Homo sapiens_hsa00310	0.44434226
163	Gastric acid secretion_Homo sapiens_hsa04971	0.44398374
164	Folate biosynthesis_Homo sapiens_hsa00790	0.44285939
165	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.43609644
166	Lysosome_Homo sapiens_hsa04142	0.43602394
167	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43343600
168	Prostate cancer_Homo sapiens_hsa05215	0.43162494
169	MAPK signaling pathway_Homo sapiens_hsa04010	0.41605608
170	Primary immunodeficiency_Homo sapiens_hsa05340	0.40803090
171	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.40638450
172	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.40344309
173	Fanconi anemia pathway_Homo sapiens_hsa03460	0.39382992
174	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39113654
175	Proteasome_Homo sapiens_hsa03050	0.38755483
176	Pyruvate metabolism_Homo sapiens_hsa00620	0.37532264
177	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36588134

TMEM67

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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