TMEM70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.44684600
2DNA deamination (GO:0045006)5.32290734
3regulation of mitochondrial translation (GO:0070129)4.54837948
4proteasome assembly (GO:0043248)4.53179698
5NADH metabolic process (GO:0006734)4.19628272
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.05031443
7oxidative phosphorylation (GO:0006119)4.03087898
8folic acid metabolic process (GO:0046655)4.02964309
9L-methionine salvage (GO:0071267)3.98471718
10L-methionine biosynthetic process (GO:0071265)3.98471718
11amino acid salvage (GO:0043102)3.98471718
12sarcoplasmic reticulum calcium ion transport (GO:0070296)3.94905813
13tricarboxylic acid cycle (GO:0006099)3.85930704
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.85627427
15L-phenylalanine metabolic process (GO:0006558)3.85627427
16lysine metabolic process (GO:0006553)3.78387782
17lysine catabolic process (GO:0006554)3.78387782
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.77081924
19pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.72128481
20chaperone-mediated protein transport (GO:0072321)3.71308594
21branched-chain amino acid catabolic process (GO:0009083)3.69243008
22mitochondrial calcium ion transport (GO:0006851)3.65495511
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.65164482
24ribosomal small subunit assembly (GO:0000028)3.63967750
25glycine metabolic process (GO:0006544)3.63274297
26purine nucleobase biosynthetic process (GO:0009113)3.62663337
27quinone biosynthetic process (GO:1901663)3.60739500
28ubiquinone biosynthetic process (GO:0006744)3.60739500
29cysteine metabolic process (GO:0006534)3.57416680
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.56178220
31ATP synthesis coupled proton transport (GO:0015986)3.56178220
322-deoxyribonucleotide biosynthetic process (GO:0009265)3.56014805
33deoxyribose phosphate biosynthetic process (GO:0046385)3.56014805
34positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.54434802
35regulation of skeletal muscle contraction (GO:0014819)3.53884852
36serine family amino acid biosynthetic process (GO:0009070)3.52971031
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.50864897
38valine metabolic process (GO:0006573)3.48260953
39pantothenate metabolic process (GO:0015939)3.46412974
40purine-containing compound salvage (GO:0043101)3.46283310
412-oxoglutarate metabolic process (GO:0006103)3.45678889
42nucleobase biosynthetic process (GO:0046112)3.45287193
43mitochondrial calcium ion homeostasis (GO:0051560)3.45091058
44respiratory electron transport chain (GO:0022904)3.43312279
45protein deneddylation (GO:0000338)3.43250062
46branched-chain amino acid metabolic process (GO:0009081)3.42628345
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.36928921
48L-phenylalanine catabolic process (GO:0006559)3.36928921
49cullin deneddylation (GO:0010388)3.36350289
50electron transport chain (GO:0022900)3.34621974
51fatty acid beta-oxidation (GO:0006635)3.32768521
52methionine metabolic process (GO:0006555)3.31714659
53serine family amino acid metabolic process (GO:0009069)3.31239276
54polyamine biosynthetic process (GO:0006596)3.30649737
55negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.29387176
56regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.29059055
57sulfur amino acid biosynthetic process (GO:0000097)3.25439042
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23946015
59serine family amino acid catabolic process (GO:0009071)3.23566808
60biotin metabolic process (GO:0006768)3.23481482
61nucleoside diphosphate biosynthetic process (GO:0009133)3.23449497
62actin-myosin filament sliding (GO:0033275)3.22429585
63muscle filament sliding (GO:0030049)3.22429585
64protein maturation by protein folding (GO:0022417)3.21288306
65maturation of SSU-rRNA (GO:0030490)3.21182971
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20909775
67L-serine metabolic process (GO:0006563)3.18963772
68transcription from mitochondrial promoter (GO:0006390)3.18306528
69regulation of cellular amino acid metabolic process (GO:0006521)3.14222766
70amino-acid betaine metabolic process (GO:0006577)3.14003525
71S-adenosylmethionine metabolic process (GO:0046500)3.13827385
72iron-sulfur cluster assembly (GO:0016226)3.13628301
73metallo-sulfur cluster assembly (GO:0031163)3.13628301
74ribosomal large subunit biogenesis (GO:0042273)3.13166032
75protein complex biogenesis (GO:0070271)3.13133746
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12731561
77protein targeting to mitochondrion (GO:0006626)3.12483196
78oxaloacetate metabolic process (GO:0006107)3.10594372
79nucleotide salvage (GO:0043173)3.10270482
80mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09724184
81mitochondrial respiratory chain complex I assembly (GO:0032981)3.09724184
82NADH dehydrogenase complex assembly (GO:0010257)3.09724184
83negative regulation of ligase activity (GO:0051352)3.09287054
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09287054
85regulation of oxidative phosphorylation (GO:0002082)3.08062764
86mitochondrial respiratory chain complex assembly (GO:0033108)3.07325844
87polyamine metabolic process (GO:0006595)3.06520422
88AMP metabolic process (GO:0046033)3.06093423
89methionine biosynthetic process (GO:0009086)3.05627285
90succinate metabolic process (GO:0006105)3.04734831
91regulation of acyl-CoA biosynthetic process (GO:0050812)3.04427496
92aromatic amino acid family catabolic process (GO:0009074)3.04412070
93ribosome assembly (GO:0042255)3.03666180
94negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.02926894
95transcription elongation from RNA polymerase III promoter (GO:0006385)3.02922680
96termination of RNA polymerase III transcription (GO:0006386)3.02922680
97neutrophil activation involved in immune response (GO:0002283)3.02139817
98heart process (GO:0003015)3.02066403
99heart contraction (GO:0060047)3.02066403
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.02055568
101skeletal muscle contraction (GO:0003009)3.01705032
102purine nucleotide salvage (GO:0032261)3.01444184
103fatty acid oxidation (GO:0019395)3.00603480
104fatty acid catabolic process (GO:0009062)3.00495193
105peptidyl-histidine modification (GO:0018202)2.99462532
106mitochondrial transport (GO:0006839)2.99298884
107establishment of protein localization to mitochondrion (GO:0072655)2.98222065
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97326481
109respiratory chain complex IV assembly (GO:0008535)2.96288680
110aspartate family amino acid metabolic process (GO:0009066)2.95948833
111negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.95911463
112tricarboxylic acid metabolic process (GO:0072350)2.95399122
113GDP-mannose metabolic process (GO:0019673)2.95073177
114ubiquinone metabolic process (GO:0006743)2.94947390
115glyoxylate metabolic process (GO:0046487)2.94072718
116protein localization to mitochondrion (GO:0070585)2.93561035
117cellular ketone body metabolic process (GO:0046950)2.93267847
118lipid oxidation (GO:0034440)2.92976888
119sulfur amino acid metabolic process (GO:0000096)2.92904067
120cellular metabolic compound salvage (GO:0043094)2.92370421
121positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92228508
122IMP metabolic process (GO:0046040)2.91745464
123deoxyribonucleotide biosynthetic process (GO:0009263)2.91593696
124tryptophan catabolic process (GO:0006569)2.90595435
125indole-containing compound catabolic process (GO:0042436)2.90595435
126indolalkylamine catabolic process (GO:0046218)2.90595435
127regulation of cofactor metabolic process (GO:0051193)2.90394536
128regulation of coenzyme metabolic process (GO:0051196)2.90394536
129translational termination (GO:0006415)2.88915475
130aerobic respiration (GO:0009060)2.88234016
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87541763
132folic acid transport (GO:0015884)2.85923586
133cellular response to arsenic-containing substance (GO:0071243)2.84503576
134IMP biosynthetic process (GO:0006188)2.84457779
135positive regulation of ligase activity (GO:0051351)2.82217043
136kynurenine metabolic process (GO:0070189)2.82046159
137viral transcription (GO:0019083)2.81996356
138regulation of cellular respiration (GO:0043457)2.80519243
139inner mitochondrial membrane organization (GO:0007007)2.80483306
140pyrimidine nucleotide catabolic process (GO:0006244)2.79798123
141positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.79560955
142pseudouridine synthesis (GO:0001522)2.79055904
143cellular component biogenesis (GO:0044085)2.78045149
144anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77674103
145sulfur amino acid catabolic process (GO:0000098)2.77626630
146deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73967836
147antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72265566
148antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.71887725
149DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.70072483
150deoxyribonucleotide catabolic process (GO:0009264)2.68890820
151deoxyribose phosphate catabolic process (GO:0046386)2.68849157
152regulation of ubiquitin-protein transferase activity (GO:0051438)2.63128772
153intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63089425
154signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63089425
155de novo protein folding (GO:0006458)2.62521086
156rRNA modification (GO:0000154)2.62035118
157deoxyribose phosphate metabolic process (GO:0019692)2.59379987
158signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.59343115
159signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.59343115
160signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.59343115
161glycosphingolipid catabolic process (GO:0046479)2.59172521
162regulation of ligase activity (GO:0051340)2.55974150
163nucleobase-containing small molecule interconversion (GO:0015949)2.55746072
164tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55032374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.47918093
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.19269655
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.11223632
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.09087062
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80558336
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68837080
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.59584538
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.57582218
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54295485
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.23441463
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04307095
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.98683362
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95241880
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94246596
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.79017317
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57120574
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43407614
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.42385171
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.35867888
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35415460
21VDR_23849224_ChIP-Seq_CD4+_Human2.35090613
22* SRF_21415370_ChIP-Seq_HL-1_Mouse2.35028635
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29473520
24DCP1A_22483619_ChIP-Seq_HELA_Human2.27247885
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17450606
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15315257
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14545577
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12159344
29E2F7_22180533_ChIP-Seq_HELA_Human2.06859556
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03777687
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03216762
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00677763
33GABP_19822575_ChIP-Seq_HepG2_Human1.99534015
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98590863
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89490958
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88953788
37XRN2_22483619_ChIP-Seq_HELA_Human1.88467779
38FOXP3_21729870_ChIP-Seq_TREG_Human1.82182788
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82053893
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79955139
41TFEB_21752829_ChIP-Seq_HELA_Human1.78381148
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78213526
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77494972
44* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.73710278
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69207068
46AR_21909140_ChIP-Seq_LNCAP_Human1.67561758
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66574541
48* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61365284
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59929540
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.58898160
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58838121
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.58119160
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54671980
54LXR_22158963_ChIP-Seq_LIVER_Mouse1.54255211
55ZNF263_19887448_ChIP-Seq_K562_Human1.53170094
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.51216974
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50494938
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48759393
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44995204
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43188769
61TTF2_22483619_ChIP-Seq_HELA_Human1.42582185
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40846939
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38681613
64GATA1_22025678_ChIP-Seq_K562_Human1.37763522
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34238232
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30758574
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29517303
68* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28161814
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27180944
70SPI1_23547873_ChIP-Seq_NB4_Human1.27051956
71* ELK1_19687146_ChIP-ChIP_HELA_Human1.26711147
72E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26540498
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26025701
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.22825460
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18266514
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17632286
77* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15121991
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13923981
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11865030
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07786925
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06770374
82MYC_18940864_ChIP-ChIP_HL60_Human1.05933757
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05414556
84* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04635773
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04033249
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02571636
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01642771
88* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00863898
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00655527
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98314155
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98085846
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97415642
93* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95195972
94KDM5A_27292631_Chip-Seq_BREAST_Human0.94255435
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94244169
96HTT_18923047_ChIP-ChIP_STHdh_Human0.94126128
97CIITA_25753668_ChIP-Seq_RAJI_Human0.92709634
98MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92571086
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90775431
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90134421
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89789768
102SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89567424
103E2F1_21310950_ChIP-Seq_MCF-7_Human0.89379103
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89286166
105* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89045754
106GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88681137
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87707731
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87597049
109* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86785338
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86472213
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85938462
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84758280
113CLOCK_20551151_ChIP-Seq_293T_Human0.84131300
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83520314
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82871396
116* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82634418
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79754682
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79333464
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.77466347
120* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76503298
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76330085
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75943116
123* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.75941032
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.75552286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.75123661
2MP0005360_urolithiasis4.44827286
3MP0003806_abnormal_nucleotide_metabolis4.16954723
4MP0005085_abnormal_gallbladder_physiolo3.82908220
5MP0005365_abnormal_bile_salt3.70806298
6MP0005058_abnormal_lysosome_morphology3.41657655
7MP0003646_muscle_fatigue3.25046387
8MP0003195_calcinosis3.09872170
9MP0006036_abnormal_mitochondrial_physio3.00198212
10MP0009840_abnormal_foam_cell2.92158427
11MP0008875_abnormal_xenobiotic_pharmacok2.88238770
12MP0005464_abnormal_platelet_physiology2.76554973
13MP0003693_abnormal_embryo_hatching2.63239848
14MP0005332_abnormal_amino_acid2.56497816
15MP0003186_abnormal_redox_activity2.42530724
16MP0004510_myositis2.38773380
17MP0006035_abnormal_mitochondrial_morpho2.34090162
18MP0002332_abnormal_exercise_endurance2.31086807
19MP0002148_abnormal_hypersensitivity_rea2.30661211
20MP0003303_peritoneal_inflammation2.17566411
21MP0010329_abnormal_lipoprotein_level2.07036739
22MP0001764_abnormal_homeostasis1.99546038
23MP0009379_abnormal_foot_pigmentation1.98727329
24MP0002837_dystrophic_cardiac_calcinosis1.97742473
25MP0004215_abnormal_myocardial_fiber1.96734569
26MP0003656_abnormal_erythrocyte_physiolo1.96733704
27MP0005319_abnormal_enzyme/_coenzyme1.92520206
28MP0003718_maternal_effect1.91900159
29MP0000749_muscle_degeneration1.76209658
30MP0004147_increased_porphyrin_level1.75392371
31MP0004233_abnormal_muscle_weight1.74164745
32MP0000372_irregular_coat_pigmentation1.72335350
33MP0005330_cardiomyopathy1.71064067
34MP0004957_abnormal_blastocyst_morpholog1.68096205
35MP0001666_abnormal_nutrient_absorption1.64208128
36MP0004019_abnormal_vitamin_homeostasis1.64158773
37MP0005584_abnormal_enzyme/coenzyme_acti1.56690754
38MP0001835_abnormal_antigen_presentation1.56494272
39MP0000609_abnormal_liver_physiology1.53922896
40MP0002396_abnormal_hematopoietic_system1.53260877
41MP0002877_abnormal_melanocyte_morpholog1.51353292
42MP0005636_abnormal_mineral_homeostasis1.51165891
43MP0003221_abnormal_cardiomyocyte_apopto1.50879046
44MP0004130_abnormal_muscle_cell1.50462533
45MP0005671_abnormal_response_to1.47445257
46MP0005670_abnormal_white_adipose1.47432653
47MP0009333_abnormal_splenocyte_physiolog1.46695838
48MP0004084_abnormal_cardiac_muscle1.44806255
49MP0009643_abnormal_urine_homeostasis1.43477970
50MP0000759_abnormal_skeletal_muscle1.42509576
51MP0005083_abnormal_biliary_tract1.41776036
52MP0002118_abnormal_lipid_homeostasis1.40140794
53MP0005167_abnormal_blood-brain_barrier1.39978671
54MP0009697_abnormal_copulation1.39888028
55MP0002972_abnormal_cardiac_muscle1.36001507
56MP0003252_abnormal_bile_duct1.35563945
57MP0003191_abnormal_cellular_cholesterol1.31629358
58MP0001853_heart_inflammation1.26094150
59MP0002138_abnormal_hepatobiliary_system1.22540867
60MP0002269_muscular_atrophy1.22287246
61MP0005451_abnormal_body_composition1.21250594
62MP0003075_altered_response_to1.20444154
63MP0005084_abnormal_gallbladder_morpholo1.19452058
64MP0005000_abnormal_immune_tolerance1.19383216
65MP0006082_CNS_inflammation1.17573630
66MP0000747_muscle_weakness1.17041351
67MP0001727_abnormal_embryo_implantation1.16364808
68MP0008260_abnormal_autophagy1.16207300
69MP0003868_abnormal_feces_composition1.12045213
70MP0004036_abnormal_muscle_relaxation1.11325119
71MP0005666_abnormal_adipose_tissue1.09685468
72MP0001790_abnormal_immune_system1.08975134
73MP0005387_immune_system_phenotype1.08975134
74MP0003111_abnormal_nucleus_morphology1.08615899
75MP0002090_abnormal_vision1.08519575
76MP0005165_increased_susceptibility_to1.05530976
77MP0000751_myopathy1.05286616
78MP0000750_abnormal_muscle_regeneration1.04942856
79MP0005266_abnormal_metabolism1.04689756
80MP0008469_abnormal_protein_level1.03808398
81MP0000490_abnormal_crypts_of1.03438707
82MP0001661_extended_life_span1.02239015
83MP0002971_abnormal_brown_adipose1.01868715
84MP0000358_abnormal_cell_content/1.01827449
85MP0001529_abnormal_vocalization1.01154038
86MP0002876_abnormal_thyroid_physiology0.99189626
87MP0000598_abnormal_liver_morphology0.98878868
88MP0005397_hematopoietic_system_phenotyp0.98757594
89MP0001545_abnormal_hematopoietic_system0.98757594
90MP0002452_abnormal_antigen_presenting0.98550692
91MP0003724_increased_susceptibility_to0.98485188
92MP0001756_abnormal_urination0.96764791
93MP0005220_abnormal_exocrine_pancreas0.95386603
94MP0005166_decreased_susceptibility_to0.94869684
95MP0002419_abnormal_innate_immunity0.93755002
96MP0008007_abnormal_cellular_replicative0.93734073
97MP0002723_abnormal_immune_serum0.93449324
98MP0000685_abnormal_immune_system0.92982596
99MP0003436_decreased_susceptibility_to0.92538331
100MP0003879_abnormal_hair_cell0.91968574
101MP0005369_muscle_phenotype0.91361506
102MP0008058_abnormal_DNA_repair0.90754879
103MP0006054_spinal_hemorrhage0.90670277
104MP0010094_abnormal_chromosome_stability0.89460005
105MP0003077_abnormal_cell_cycle0.87029425
106MP0008775_abnormal_heart_ventricle0.86331674
107MP0005647_abnormal_sex_gland0.85981530
108MP0008874_decreased_physiological_sensi0.85563657
109MP0001845_abnormal_inflammatory_respons0.85210100
110MP0009763_increased_sensitivity_to0.82352456
111MP0005376_homeostasis/metabolism_phenot0.80433125
112MP0005410_abnormal_fertilization0.80342633
113MP0002106_abnormal_muscle_physiology0.80149927
114MP0001800_abnormal_humoral_immune0.80025257
115MP0009046_muscle_twitch0.79926635
116MP0001905_abnormal_dopamine_level0.79834834
117MP0009642_abnormal_blood_homeostasis0.79586742
118MP0003786_premature_aging0.78962731
119MP0005535_abnormal_body_temperature0.78435153
120MP0005620_abnormal_muscle_contractility0.78413151
121MP0005025_abnormal_response_to0.77617139
122MP0002078_abnormal_glucose_homeostasis0.77596911
123MP0009764_decreased_sensitivity_to0.77457720
124MP0005385_cardiovascular_system_phenoty0.76900487
125MP0001544_abnormal_cardiovascular_syste0.76900487
126MP0004145_abnormal_muscle_electrophysio0.76796135
127MP0000465_gastrointestinal_hemorrhage0.76110871
128MP0008004_abnormal_stomach_pH0.75162393
129MP0000313_abnormal_cell_death0.74418994
130MP0003137_abnormal_impulse_conducting0.72908090
131MP0004087_abnormal_muscle_fiber0.72499095
132MP0002420_abnormal_adaptive_immunity0.71804681
133MP0003567_abnormal_fetal_cardiomyocyte0.70385845
134MP0009785_altered_susceptibility_to0.69975441
135MP0001819_abnormal_immune_cell0.69907055
136MP0001542_abnormal_bone_strength0.69430169
137MP0000343_altered_response_to0.68737051
138MP0005395_other_phenotype0.68275203
139MP0002132_abnormal_respiratory_system0.68271457
140MP0005334_abnormal_fat_pad0.64533484
141MP0002970_abnormal_white_adipose0.61927700
142MP0000013_abnormal_adipose_tissue0.61260317
143MP0000230_abnormal_systemic_arterial0.61104693
144MP0008932_abnormal_embryonic_tissue0.60749299

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.52443354
2Exercise-induced muscle cramps (HP:0003710)4.25142780
3Decreased activity of mitochondrial respiratory chain (HP:0008972)4.12355176
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.12355176
5Hepatocellular necrosis (HP:0001404)4.05440066
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.94419772
7Abnormality of dicarboxylic acid metabolism (HP:0010995)3.89759532
8Dicarboxylic aciduria (HP:0003215)3.89759532
9Abnormality of fatty-acid metabolism (HP:0004359)3.85988873
10Hyperglycinuria (HP:0003108)3.84065992
11Hyperglycinemia (HP:0002154)3.82844029
12* Abnormality of alanine metabolism (HP:0010916)3.77714042
13* Hyperalaninemia (HP:0003348)3.77714042
14* Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.77714042
15Increased muscle lipid content (HP:0009058)3.73293256
16Increased intramyocellular lipid droplets (HP:0012240)3.61825878
17Exercise-induced myalgia (HP:0003738)3.58631375
18Hypoglycemic coma (HP:0001325)3.57621822
19Abnormality of glycine metabolism (HP:0010895)3.52448681
20Abnormality of serine family amino acid metabolism (HP:0010894)3.52448681
21* Lactic acidosis (HP:0003128)3.51543845
22Abnormal mitochondria in muscle tissue (HP:0008316)3.49157624
23Increased CSF lactate (HP:0002490)3.47534880
24Mitochondrial inheritance (HP:0001427)3.44057725
25* Abnormality of serum amino acid levels (HP:0003112)3.39946950
26Cerebral edema (HP:0002181)3.37824315
27* Increased serum lactate (HP:0002151)3.32829179
28Acute encephalopathy (HP:0006846)3.32351074
29Generalized aminoaciduria (HP:0002909)3.30438977
30Lethargy (HP:0001254)3.28770372
31Acute necrotizing encephalopathy (HP:0006965)3.25802839
32* Hyperammonemia (HP:0001987)3.25649516
33Lipid accumulation in hepatocytes (HP:0006561)3.20218467
34Paralysis (HP:0003470)3.20063609
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.18646432
36Ketosis (HP:0001946)3.07695504
37Abnormality of glycolipid metabolism (HP:0010969)3.05950284
38Abnormality of liposaccharide metabolism (HP:0010968)3.05950284
39Abnormality of glycosphingolipid metabolism (HP:0004343)3.05950284
40Proximal tubulopathy (HP:0000114)3.02380782
41Progressive muscle weakness (HP:0003323)2.99509306
42Nausea (HP:0002018)2.96509767
43Increased hepatocellular lipid droplets (HP:0006565)2.93710656
44Petechiae (HP:0000967)2.92212092
45Ketoacidosis (HP:0001993)2.89139265
46Rimmed vacuoles (HP:0003805)2.88085478
47Abnormality of lateral ventricle (HP:0030047)2.87629706
48Gout (HP:0001997)2.85843154
49Myoglobinuria (HP:0002913)2.84814373
50Rhabdomyolysis (HP:0003201)2.83746962
51Type 1 muscle fiber predominance (HP:0003803)2.82166568
52CNS demyelination (HP:0007305)2.82034796
53Abnormality of glycolysis (HP:0004366)2.74283933
54Increased serum pyruvate (HP:0003542)2.74283933
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71540080
56Methylmalonic aciduria (HP:0012120)2.68913218
57Reduced antithrombin III activity (HP:0001976)2.67902432
58Metabolic acidosis (HP:0001942)2.67816096
59Exercise intolerance (HP:0003546)2.67111105
60Purpura (HP:0000979)2.63971615
61Ragged-red muscle fibers (HP:0003200)2.61830995
62Glycosuria (HP:0003076)2.60621997
63Abnormality of urine glucose concentration (HP:0011016)2.60621997
64Hypobetalipoproteinemia (HP:0003563)2.60523751
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.57533633
66Intrahepatic cholestasis (HP:0001406)2.57307189
67Type I transferrin isoform profile (HP:0003642)2.55891167
68Progressive macrocephaly (HP:0004481)2.52080535
69EMG: myopathic abnormalities (HP:0003458)2.51615471
70Vacuolated lymphocytes (HP:0001922)2.50918816
71Hyperlipoproteinemia (HP:0010980)2.50650894
72Xanthomatosis (HP:0000991)2.48630517
73Respiratory failure (HP:0002878)2.47129613
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42680670
75Prolonged partial thromboplastin time (HP:0003645)2.42579366
76Oral leukoplakia (HP:0002745)2.42208457
77Abnormality of the anterior horn cell (HP:0006802)2.38736635
78Degeneration of anterior horn cells (HP:0002398)2.38736635
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35619800
80Abnormality of cells of the erythroid lineage (HP:0012130)2.35355455
81Megaloblastic anemia (HP:0001889)2.34536370
82Distal arthrogryposis (HP:0005684)2.33871064
83Renal Fanconi syndrome (HP:0001994)2.33817283
84Abnormal number of erythroid precursors (HP:0012131)2.31544508
85Muscle fiber splitting (HP:0003555)2.31145128
86Type 2 muscle fiber atrophy (HP:0003554)2.30942708
87Muscle hypertrophy of the lower extremities (HP:0008968)2.30018920
88Vomiting (HP:0002013)2.28185627
89Multiple enchondromatosis (HP:0005701)2.27679323
90Hypolipoproteinemia (HP:0010981)2.24696094
91Delayed CNS myelination (HP:0002188)2.23923128
92Hepatosplenomegaly (HP:0001433)2.23297398
93Abnormality of methionine metabolism (HP:0010901)2.22801257
94Muscle fiber atrophy (HP:0100295)2.22624186
95Palpitations (HP:0001962)2.21274237
96Hyperuricemia (HP:0002149)2.21028652
97Increased purine levels (HP:0004368)2.21028652
98Prolonged bleeding time (HP:0003010)2.17559151
99Abnormal protein glycosylation (HP:0012346)2.17524562
100Abnormal glycosylation (HP:0012345)2.17524562
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17524562
102Abnormal protein N-linked glycosylation (HP:0012347)2.17524562
103Neck muscle weakness (HP:0000467)2.11815331
104Hypoalphalipoproteinemia (HP:0003233)2.10536204
105Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.09776864
106Nemaline bodies (HP:0003798)2.06431408
107Abnormality of purine metabolism (HP:0004352)2.04726116
108Macrocytic anemia (HP:0001972)2.04377825
109Increased serum ferritin (HP:0003281)2.02620058
110Centrally nucleated skeletal muscle fibers (HP:0003687)2.02137133
111Brushfield spots (HP:0001088)2.02104527
112Respiratory difficulties (HP:0002880)2.02093511
113Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01238756
114Mutism (HP:0002300)2.01197555
115Aplastic anemia (HP:0001915)1.99587659
116Muscle fiber inclusion bodies (HP:0100299)1.98815063
117Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98460799
118Abnormality of nucleobase metabolism (HP:0010932)1.98265617
119Abnormality of the intrinsic pathway (HP:0010989)1.98195703
120Reduced subcutaneous adipose tissue (HP:0003758)1.98048986
121Abnormality of the heme biosynthetic pathway (HP:0010472)1.92957546
122Emotional lability (HP:0000712)1.92392307
123Exertional dyspnea (HP:0002875)1.91641467
124Optic disc pallor (HP:0000543)1.91240566
125Tinnitus (HP:0000360)1.90855773
126Leukodystrophy (HP:0002415)1.90429690
127Abnormality of sulfur amino acid metabolism (HP:0004339)1.89880380
128Hyperbilirubinemia (HP:0002904)1.89824584
129Muscle stiffness (HP:0003552)1.89646715
130Calf muscle hypertrophy (HP:0008981)1.89415551
131Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89177557
132Microvesicular hepatic steatosis (HP:0001414)1.88462121
133Progressive external ophthalmoplegia (HP:0000590)1.86598064
134Myopathic facies (HP:0002058)1.86469897
135Gliosis (HP:0002171)1.85913451
136Shoulder girdle muscle weakness (HP:0003547)1.85379765
137Abnormality of pyrimidine metabolism (HP:0004353)1.85344619
138Distal lower limb muscle weakness (HP:0009053)1.84001889
139Delusions (HP:0000746)1.83791356
140* 3-Methylglutaconic aciduria (HP:0003535)1.81389701
141Fasciculations (HP:0002380)1.79353214
142Areflexia of lower limbs (HP:0002522)1.78954066
143Amniotic constriction ring (HP:0009775)1.77874330
144Abnormality of placental membranes (HP:0011409)1.77874330
145Sensorimotor neuropathy (HP:0007141)1.77685779
146Abnormality of macrophages (HP:0004311)1.75815103
147Cerebral hypomyelination (HP:0006808)1.75496027
148Disinhibition (HP:0000734)1.75464212
149Increased IgM level (HP:0003496)1.75013472
150Frequent falls (HP:0002359)1.74410766
151X-linked dominant inheritance (HP:0001423)1.73417900

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.00682268
2NME24.89790205
3EIF2AK14.09782120
4STK163.75989772
5MST43.19367958
6BUB13.08423640
7WEE12.94383139
8NME12.57114116
9NEK12.03447718
10PIM22.03137262
11PINK11.99818611
12PBK1.96019312
13MAPKAPK31.95931140
14EIF2AK31.94661700
15PDK41.88088145
16PDK31.88088145
17ARAF1.78388655
18TESK11.71607904
19DYRK31.70851396
20FLT31.70487286
21MUSK1.66804027
22VRK21.61876324
23MAP3K111.61243108
24LIMK11.57947618
25RPS6KA41.55928344
26NEK91.55582433
27KDR1.50385534
28TRIB31.49918168
29BRSK21.49025324
30VRK11.30843874
31CSNK1G31.29479755
32TAOK21.29457277
33ZAK1.24640899
34CCNB11.23080254
35OBSCN1.22770731
36RIPK41.19153574
37TIE11.18881439
38TAOK11.16266490
39ACVR1B1.16082428
40TSSK61.16034062
41PLK41.14957966
42ABL21.14804878
43DAPK11.11665964
44MAP2K31.10807860
45SRPK11.07535218
46CAMKK21.06930364
47GRK71.06900384
48TRIM281.05611408
49NEK21.04850901
50IRAK31.03460548
51LMTK21.02790983
52MATK1.02551039
53EPHA21.01917396
54BRAF1.00197436
55MST1R0.99223284
56MOS0.98728568
57CSNK1G20.95521706
58PIK3CG0.95427327
59PDK20.94441363
60ERN10.91723020
61CDC70.91126605
62MAP3K50.90567245
63DAPK30.89846757
64TTN0.89328529
65PKN20.89085907
66SIK30.88959686
67IKBKB0.86074029
68TESK20.84263699
69TTK0.83797953
70TYK20.82015034
71CSNK1A1L0.81078360
72MYLK0.80276860
73RAF10.79770646
74MAP3K120.78835587
75MARK30.78729573
76MAPK110.78146174
77BMX0.77746281
78CSNK1G10.76938710
79AURKB0.75990911
80PLK10.75011940
81PAK10.73439843
82ADRBK20.73059267
83AURKA0.71181274
84ILK0.70339860
85CDK80.70075346
86CDK190.69736005
87MAP4K20.69170119
88BRSK10.68818286
89STK240.66979461
90MAP3K30.63732261
91RPS6KB20.63684332
92EIF2AK20.63585634
93MAP2K70.62694365
94GRK50.61047517
95TLK10.58778194
96SCYL20.54834061
97MAP2K60.54346859
98TBK10.52863553
99NLK0.52337638
100MAP3K140.51831057
101CDK40.51392726
102CAMK2G0.51031715
103CSF1R0.50913930
104PKN10.50380007
105TEC0.50303971
106PRKG20.49332997
107MAP3K80.48599121
108PHKG10.48214068
109PHKG20.48214068
110KIT0.47351326
111CDK140.46473416
112STK38L0.45679068
113PAK40.43125789
114MAP3K130.42716151
115CSNK2A10.42397867
116CDK70.41170337
117MAPK120.40889556
118BLK0.40404538
119FGFR40.37679068
120ERBB30.36862932
121PIM10.36563167
122AKT20.36478368
123IRAK10.35685595
124TGFBR10.34637129
125ALK0.34240482
126CAMK2D0.34206212
127NUAK10.33980235
128CAMK2A0.33910209
129CSNK2A20.33744402
130IRAK20.31436767
131FGR0.30688627
132PRKAA20.30565554
133LRRK20.30333383
134RPS6KA50.28594068
135PLK30.27911856
136MAP2K10.27381278
137INSRR0.27213897
138MAPK40.25172703
139BMPR20.25057799
140SYK0.23992283

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.16426860
2Proteasome_Homo sapiens_hsa030502.84279035
3Propanoate metabolism_Homo sapiens_hsa006402.67386500
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60741186
5Ribosome_Homo sapiens_hsa030102.58133093
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.57012352
7Folate biosynthesis_Homo sapiens_hsa007902.54200665
8Fatty acid degradation_Homo sapiens_hsa000712.52483483
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.47693526
10Sulfur relay system_Homo sapiens_hsa041222.28622829
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26815984
12RNA polymerase_Homo sapiens_hsa030202.13848450
13Carbon metabolism_Homo sapiens_hsa012002.11912245
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06565022
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04830211
16Oxidative phosphorylation_Homo sapiens_hsa001902.03639434
17Primary bile acid biosynthesis_Homo sapiens_hsa001202.01600598
18Parkinsons disease_Homo sapiens_hsa050121.96339387
19Pyrimidine metabolism_Homo sapiens_hsa002401.88260677
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.87152443
21Peroxisome_Homo sapiens_hsa041461.81991168
22Collecting duct acid secretion_Homo sapiens_hsa049661.79258480
23Pyruvate metabolism_Homo sapiens_hsa006201.74109469
24DNA replication_Homo sapiens_hsa030301.71636143
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71087293
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.70926108
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69136145
28Fatty acid metabolism_Homo sapiens_hsa012121.67357285
29Biosynthesis of amino acids_Homo sapiens_hsa012301.62418840
30Butanoate metabolism_Homo sapiens_hsa006501.60818669
31Pentose phosphate pathway_Homo sapiens_hsa000301.59579224
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55641675
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51524924
34Vitamin B6 metabolism_Homo sapiens_hsa007501.48861509
35Tryptophan metabolism_Homo sapiens_hsa003801.46733253
36Selenocompound metabolism_Homo sapiens_hsa004501.44316481
37beta-Alanine metabolism_Homo sapiens_hsa004101.43236359
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38112120
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33768434
40Rheumatoid arthritis_Homo sapiens_hsa053231.33384573
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31013263
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30523838
43Huntingtons disease_Homo sapiens_hsa050161.30260426
44Lysosome_Homo sapiens_hsa041421.25717444
45Systemic lupus erythematosus_Homo sapiens_hsa053221.22815897
46Arginine biosynthesis_Homo sapiens_hsa002201.21660902
47Alzheimers disease_Homo sapiens_hsa050101.16975356
48Caffeine metabolism_Homo sapiens_hsa002321.16058706
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15402850
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14968421
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13293680
52PPAR signaling pathway_Homo sapiens_hsa033201.11920256
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08748894
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07010113
55Fructose and mannose metabolism_Homo sapiens_hsa000511.06770020
56Glutathione metabolism_Homo sapiens_hsa004801.05514627
57Protein export_Homo sapiens_hsa030601.05340453
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04251976
59Vibrio cholerae infection_Homo sapiens_hsa051101.03504350
60Fatty acid elongation_Homo sapiens_hsa000621.03384809
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01090190
62Sulfur metabolism_Homo sapiens_hsa009201.01012196
63Legionellosis_Homo sapiens_hsa051341.00718701
64One carbon pool by folate_Homo sapiens_hsa006700.98155041
65Purine metabolism_Homo sapiens_hsa002300.97941968
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96375274
67Chemical carcinogenesis_Homo sapiens_hsa052040.96283214
68Metabolic pathways_Homo sapiens_hsa011000.95665050
69Arginine and proline metabolism_Homo sapiens_hsa003300.93976199
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91953280
71Base excision repair_Homo sapiens_hsa034100.91403049
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.87980347
73RNA transport_Homo sapiens_hsa030130.87231780
74Shigellosis_Homo sapiens_hsa051310.84314854
75Nucleotide excision repair_Homo sapiens_hsa034200.84176064
76Retinol metabolism_Homo sapiens_hsa008300.84128877
77Starch and sucrose metabolism_Homo sapiens_hsa005000.83793072
78Mismatch repair_Homo sapiens_hsa034300.83733963
79Nitrogen metabolism_Homo sapiens_hsa009100.74993708
80Cardiac muscle contraction_Homo sapiens_hsa042600.74333352
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73564315
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.72815705
83Vitamin digestion and absorption_Homo sapiens_hsa049770.72447625
84Phenylalanine metabolism_Homo sapiens_hsa003600.72120331
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71633325
86Complement and coagulation cascades_Homo sapiens_hsa046100.70072386
87Phagosome_Homo sapiens_hsa041450.68661475
88Homologous recombination_Homo sapiens_hsa034400.68310692
89Regulation of autophagy_Homo sapiens_hsa041400.67701225
90Spliceosome_Homo sapiens_hsa030400.65363789
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64900968
92Epstein-Barr virus infection_Homo sapiens_hsa051690.62970962
93Asthma_Homo sapiens_hsa053100.61811276
94Synaptic vesicle cycle_Homo sapiens_hsa047210.61168352
95Fat digestion and absorption_Homo sapiens_hsa049750.60912454
96Galactose metabolism_Homo sapiens_hsa000520.58943445
97Salmonella infection_Homo sapiens_hsa051320.58747219
98Other glycan degradation_Homo sapiens_hsa005110.56930213
99Histidine metabolism_Homo sapiens_hsa003400.56826701
100Viral myocarditis_Homo sapiens_hsa054160.55257808
101Allograft rejection_Homo sapiens_hsa053300.54289408
102Primary immunodeficiency_Homo sapiens_hsa053400.54093168
103RNA degradation_Homo sapiens_hsa030180.53586404
104Tyrosine metabolism_Homo sapiens_hsa003500.52701248
105Glycerolipid metabolism_Homo sapiens_hsa005610.50999325
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48088961
107Hematopoietic cell lineage_Homo sapiens_hsa046400.47980428
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47530197
109Oocyte meiosis_Homo sapiens_hsa041140.46812669
110Alcoholism_Homo sapiens_hsa050340.43621217
111p53 signaling pathway_Homo sapiens_hsa041150.42075631
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.41809357
113Herpes simplex infection_Homo sapiens_hsa051680.39288510
114Viral carcinogenesis_Homo sapiens_hsa052030.36899746
115Cell cycle_Homo sapiens_hsa041100.36800433
116Tuberculosis_Homo sapiens_hsa051520.36687823
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.34194829
118Antigen processing and presentation_Homo sapiens_hsa046120.33163998
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33123385
120Type I diabetes mellitus_Homo sapiens_hsa049400.32831828
121Graft-versus-host disease_Homo sapiens_hsa053320.32516556
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.32043639
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.29302039
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29083757
125Autoimmune thyroid disease_Homo sapiens_hsa053200.28713444
126Pertussis_Homo sapiens_hsa051330.26998235
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26378315
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.24741035
129Basal transcription factors_Homo sapiens_hsa030220.21775332
130Arachidonic acid metabolism_Homo sapiens_hsa005900.19734044
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16055320
132N-Glycan biosynthesis_Homo sapiens_hsa005100.15515453
133ABC transporters_Homo sapiens_hsa020100.14953471
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.12508111
135Bile secretion_Homo sapiens_hsa049760.11710491
136Fanconi anemia pathway_Homo sapiens_hsa034600.11618633
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09836513

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