TMEM71

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.51558870
2negative regulation of cell killing (GO:0031342)6.97982377
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.97982377
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.38564110
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.38564110
6negative T cell selection (GO:0043383)6.36789473
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.16069633
8negative thymic T cell selection (GO:0045060)5.96708266
9leukocyte aggregation (GO:0070486)5.91737128
10interferon-gamma production (GO:0032609)5.90929843
11regulation of gamma-delta T cell differentiation (GO:0045586)5.88733765
12positive thymic T cell selection (GO:0045059)5.81986873
13positive regulation by symbiont of host defense response (GO:0052509)5.72267946
14modulation by symbiont of host defense response (GO:0052031)5.72267946
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.72267946
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.72267946
17positive regulation by organism of defense response of other organism involved in symbiotic interact5.72267946
18modulation by symbiont of host immune response (GO:0052553)5.72267946
19regulation of B cell receptor signaling pathway (GO:0050855)5.57006777
20T cell migration (GO:0072678)5.50760435
21antigen processing and presentation of endogenous antigen (GO:0019883)5.50143945
22regulation of gamma-delta T cell activation (GO:0046643)5.44465278
23positive T cell selection (GO:0043368)5.41390278
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.13790214
25thymic T cell selection (GO:0045061)4.93371529
26regulation of isotype switching to IgG isotypes (GO:0048302)4.90884083
27response to interleukin-15 (GO:0070672)4.89877815
28cellular response to interleukin-15 (GO:0071350)4.79667111
29detection of molecule of bacterial origin (GO:0032490)4.71004247
30T cell selection (GO:0045058)4.70981312
31macrophage activation involved in immune response (GO:0002281)4.70374321
32detection of bacterium (GO:0016045)4.60140789
33response to peptidoglycan (GO:0032494)4.56983117
34regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.46880429
35detection of external biotic stimulus (GO:0098581)4.45481439
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.32118134
37negative regulation of interleukin-12 production (GO:0032695)4.23521205
38microglial cell activation (GO:0001774)4.21714732
39T cell receptor signaling pathway (GO:0050852)4.20996635
40regulation of interferon-beta biosynthetic process (GO:0045357)4.18336555
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.11799633
42response to host immune response (GO:0052572)4.04265940
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.04265940
44activated T cell proliferation (GO:0050798)4.03154057
45regulation of B cell differentiation (GO:0045577)4.02471303
46regulation of alpha-beta T cell proliferation (GO:0046640)4.00073206
47respiratory burst (GO:0045730)3.99510620
48antigen receptor-mediated signaling pathway (GO:0050851)3.96447532
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.96403262
50T cell costimulation (GO:0031295)3.96390195
51detection of biotic stimulus (GO:0009595)3.95702660
52mast cell activation (GO:0045576)3.95162818
53leukocyte migration involved in inflammatory response (GO:0002523)3.93653270
54lymphocyte costimulation (GO:0031294)3.91429320
55granulocyte activation (GO:0036230)3.90121657
56positive regulation of alpha-beta T cell proliferation (GO:0046641)3.87980090
57regulation of interleukin-12 biosynthetic process (GO:0045075)3.86913280
58immunoglobulin mediated immune response (GO:0016064)3.86602518
59B cell receptor signaling pathway (GO:0050853)3.84244433
60negative regulation of leukocyte mediated immunity (GO:0002704)3.84235923
61neutrophil mediated immunity (GO:0002446)3.83422795
62negative regulation of T cell mediated immunity (GO:0002710)3.81489343
63leukocyte cell-cell adhesion (GO:0007159)3.81409915
64myeloid cell activation involved in immune response (GO:0002275)3.75636626
65macrophage activation (GO:0042116)3.75136630
66regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.74539517
67cellular extravasation (GO:0045123)3.73832629
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.71235346
69response to host (GO:0075136)3.71235346
70response to host defenses (GO:0052200)3.71235346
71positive regulation of isotype switching (GO:0045830)3.70428078
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.63485190
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.62703451
74regulation of natural killer cell mediated immunity (GO:0002715)3.61780777
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.61780777
76regulation of mast cell degranulation (GO:0043304)3.59533059
77regulation of T cell receptor signaling pathway (GO:0050856)3.58834199
78Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52371799
79positive regulation of natural killer cell mediated immunity (GO:0002717)3.49080745
80positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.49080745
81regulation of T cell tolerance induction (GO:0002664)3.46814187
82positive regulation of immunoglobulin mediated immune response (GO:0002891)3.44378432
83positive regulation of B cell mediated immunity (GO:0002714)3.44378432
84positive regulation of mast cell activation (GO:0033005)3.40765364
85production of molecular mediator involved in inflammatory response (GO:0002532)3.40239715
86regulation of regulatory T cell differentiation (GO:0045589)3.40189495
87regulation of tolerance induction (GO:0002643)3.35877681
88positive regulation of B cell differentiation (GO:0045579)3.35173241
89positive regulation of DNA recombination (GO:0045911)3.33490813
90leukocyte degranulation (GO:0043299)3.33470774
91response to muramyl dipeptide (GO:0032495)3.32138944
92regulation of mast cell activation involved in immune response (GO:0033006)3.31320653
93positive regulation of humoral immune response (GO:0002922)3.30986793
94regulation of myeloid leukocyte mediated immunity (GO:0002886)3.30358355
95negative regulation of lymphocyte mediated immunity (GO:0002707)3.29916552
96regulation of leukocyte mediated cytotoxicity (GO:0001910)3.29309359
97myeloid leukocyte mediated immunity (GO:0002444)3.28147444
98regulation of response to interferon-gamma (GO:0060330)3.27679174
99regulation of mast cell activation (GO:0033003)3.27341698
100T cell homeostasis (GO:0043029)3.25799846
101regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.23271221
102positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.21704597
103antigen processing and presentation via MHC class Ib (GO:0002475)3.20364822
104natural killer cell activation (GO:0030101)3.16323188
105response to type I interferon (GO:0034340)3.16201831
106dendritic cell migration (GO:0036336)3.15459433
107regulation of immunoglobulin mediated immune response (GO:0002889)3.15029269
108heterotypic cell-cell adhesion (GO:0034113)3.14941196
109regulation of B cell mediated immunity (GO:0002712)3.14720620
110regulation of isotype switching (GO:0045191)3.14690448
111B cell mediated immunity (GO:0019724)3.13891670
112positive regulation of T cell mediated cytotoxicity (GO:0001916)3.13834622
113regulation of leukocyte degranulation (GO:0043300)3.13008729
114negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.12385940
115negative regulation of T-helper cell differentiation (GO:0045623)3.12385940
116positive regulation of interleukin-2 production (GO:0032743)3.11176771
117cellular defense response (GO:0006968)3.10054490
118type I interferon signaling pathway (GO:0060337)3.09446895
119cellular response to type I interferon (GO:0071357)3.09446895
120T cell differentiation (GO:0030217)3.07954733
121lymphocyte migration (GO:0072676)3.07842931
122regulation of cell killing (GO:0031341)3.07461589
123dendritic cell chemotaxis (GO:0002407)3.06872447
124ribosomal small subunit assembly (GO:0000028)3.06784804
125defense response to protozoan (GO:0042832)3.05389252
126positive regulation of tolerance induction (GO:0002645)3.04939498
127positive regulation of lamellipodium assembly (GO:0010592)3.04338024
128regulation of interleukin-2 biosynthetic process (GO:0045076)3.03186548
129T cell proliferation (GO:0042098)3.01786386
130germinal center formation (GO:0002467)3.00376445
131regulation of T cell mediated cytotoxicity (GO:0001914)2.99912211
132tolerance induction (GO:0002507)2.99548988
133positive regulation of cell killing (GO:0031343)2.99258802
134sequestering of actin monomers (GO:0042989)2.98748028
135negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.98287205
136immune response-activating cell surface receptor signaling pathway (GO:0002429)2.97818772
137neutrophil activation (GO:0042119)2.97327843
138T cell activation (GO:0042110)2.96984906
139alpha-beta T cell activation (GO:0046631)2.96355293
140interferon-gamma-mediated signaling pathway (GO:0060333)2.95240566
141myeloid dendritic cell activation (GO:0001773)2.95145495
142negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93938890
143negative regulation of interleukin-6 production (GO:0032715)2.93764558
144negative regulation of phagocytosis (GO:0050765)2.93698639
145megakaryocyte development (GO:0035855)2.93532911
146lymphocyte homeostasis (GO:0002260)2.92245530
147negative regulation of innate immune response (GO:0045824)2.92166629
148regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.92155491
149detection of other organism (GO:0098543)2.90848270
150negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.88752574
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87248254
152neutrophil activation involved in immune response (GO:0002283)2.86360915
153mast cell activation involved in immune response (GO:0002279)2.86203677
154mast cell degranulation (GO:0043303)2.86203677
155positive regulation of granulocyte differentiation (GO:0030854)2.84543422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.44222767
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.64028038
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.83621855
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.13529539
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.76109578
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.44731900
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.40132343
8RUNX_20019798_ChIP-Seq_JUKART_Human3.36896723
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.33737779
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.32562000
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.15564456
12MYB_26560356_Chip-Seq_TH2_Human3.04855867
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.01178991
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.89980145
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.83866358
16MYC_22102868_ChIP-Seq_BL_Human2.72393956
17SCL_19346495_ChIP-Seq_HPC-7_Human2.71323525
18MAF_26560356_Chip-Seq_TH1_Human2.67566638
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66284163
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65761004
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.53911524
22MYB_26560356_Chip-Seq_TH1_Human2.52985290
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.51180126
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43920689
25SPI1_23547873_ChIP-Seq_NB4_Human2.42455469
26UTX_26944678_Chip-Seq_JUKART_Human2.37101290
27VDR_21846776_ChIP-Seq_THP-1_Human2.19053029
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.17297784
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.12904673
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.12668537
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10363360
32E2F7_22180533_ChIP-Seq_HELA_Human2.08912988
33ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05011192
34BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01466955
35GATA3_27048872_Chip-Seq_THYMUS_Human1.97950804
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97264049
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85805023
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85089311
39VDR_24763502_ChIP-Seq_THP-1_Human1.78969117
40TCF7_22412390_ChIP-Seq_EML_Mouse1.76109842
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73578421
42MAF_26560356_Chip-Seq_TH2_Human1.71892637
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67697454
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66433212
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66130662
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64484880
47SPI1_23127762_ChIP-Seq_K562_Human1.61931694
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.58995492
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54429627
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53918861
51PU_27001747_Chip-Seq_BMDM_Mouse1.48834885
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48797792
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38904458
54GATA3_26560356_Chip-Seq_TH2_Human1.38637641
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35666895
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35302936
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33424517
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32447481
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30101254
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29695464
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29046374
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27969998
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25807540
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25390057
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22733325
66* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20768533
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.19858789
68KDM2B_26808549_Chip-Seq_DND41_Human1.18574044
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18461328
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14935935
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14749971
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12906392
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11436727
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07394537
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07034763
76CIITA_25753668_ChIP-Seq_RAJI_Human1.06758408
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05913525
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.04640889
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03874107
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03464232
81* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02462099
82* VDR_23849224_ChIP-Seq_CD4+_Human1.00159116
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00075002
84EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99743356
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97947349
86* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97248361
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97095236
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95226846
89* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94777303
90GATA1_22025678_ChIP-Seq_K562_Human0.92513624
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.91541525
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90776971
93BCL6_27268052_Chip-Seq_Bcells_Human0.89589147
94* FOXP3_21729870_ChIP-Seq_TREG_Human0.89369209
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.89278219
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88197372
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86609551
98ELK1_19687146_ChIP-ChIP_HELA_Human0.86478084
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83526886
100VDR_24787735_ChIP-Seq_THP-1_Human0.80717157
101GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80017408
102GATA2_19941826_ChIP-Seq_K562_Human0.77906613
103NCOR1_26117541_ChIP-Seq_K562_Human0.77516468
104BCOR_27268052_Chip-Seq_Bcells_Human0.77377090
105SMRT_27268052_Chip-Seq_Bcells_Human0.77144144
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76611571
107GATA1_19941826_ChIP-Seq_K562_Human0.75267000
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74841216
109* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74753874
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.74602633
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.74102568
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73632627
113FOXM1_23109430_ChIP-Seq_U2OS_Human0.72842563
114SPI1_20517297_ChIP-Seq_HL60_Human0.69568505
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68528246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.32885424
2MP0005671_abnormal_response_to3.98004424
3MP0001835_abnormal_antigen_presentation3.59872692
4MP0000685_abnormal_immune_system3.41576307
5MP0009785_altered_susceptibility_to3.35863808
6MP0001800_abnormal_humoral_immune3.08433578
7MP0003436_decreased_susceptibility_to2.96256725
8MP0005000_abnormal_immune_tolerance2.93360754
9MP0002420_abnormal_adaptive_immunity2.90647849
10MP0001819_abnormal_immune_cell2.86681294
11MP0005387_immune_system_phenotype2.81826230
12MP0001790_abnormal_immune_system2.81826230
13MP0002723_abnormal_immune_serum2.79645856
14MP0005025_abnormal_response_to2.78133444
15MP0002452_abnormal_antigen_presenting2.71828522
16MP0003724_increased_susceptibility_to2.71616579
17MP0002166_altered_tumor_susceptibility2.71026330
18MP0002398_abnormal_bone_marrow2.67071892
19MP0002419_abnormal_innate_immunity2.46583345
20MP0002148_abnormal_hypersensitivity_rea2.45963179
21MP0000716_abnormal_immune_system2.40186522
22MP0006082_CNS_inflammation2.39547675
23MP0009333_abnormal_splenocyte_physiolog2.39288539
24MP0002405_respiratory_system_inflammati2.37178576
25MP0002396_abnormal_hematopoietic_system2.32418565
26MP0002006_tumorigenesis2.23220571
27MP0005464_abnormal_platelet_physiology2.21155695
28MP0001873_stomach_inflammation2.19274452
29MP0000689_abnormal_spleen_morphology2.18918709
30MP0002722_abnormal_immune_system2.18208286
31MP0000703_abnormal_thymus_morphology2.11846274
32MP0010155_abnormal_intestine_physiology2.07692668
33MP0002429_abnormal_blood_cell1.98590643
34MP0003303_peritoneal_inflammation1.89407074
35MP0001845_abnormal_inflammatory_respons1.86545972
36MP0000465_gastrointestinal_hemorrhage1.85450902
37MP0004808_abnormal_hematopoietic_stem1.84933532
38MP0008260_abnormal_autophagy1.84616822
39MP0004947_skin_inflammation1.83718823
40MP0003300_gastrointestinal_ulcer1.82426984
41MP0003866_abnormal_defecation1.73680011
42MP0000858_altered_metastatic_potential1.70813782
43MP0001853_heart_inflammation1.70048737
44MP0002933_joint_inflammation1.68911879
45MP0009278_abnormal_bone_marrow1.68304314
46MP0001545_abnormal_hematopoietic_system1.58115056
47MP0005397_hematopoietic_system_phenotyp1.58115056
48MP0003448_altered_tumor_morphology1.42956368
49MP0004510_myositis1.39380502
50MP0002009_preneoplasia1.37469004
51MP0001533_abnormal_skeleton_physiology1.36621976
52MP0002132_abnormal_respiratory_system1.36363343
53MP0004883_abnormal_blood_vessel1.36218798
54MP0008469_abnormal_protein_level1.34549898
55MP0005451_abnormal_body_composition1.34437608
56MP0004381_abnormal_hair_follicle1.31954074
57MP0005075_abnormal_melanosome_morpholog1.27103112
58MP0000490_abnormal_crypts_of1.21936088
59MP0009764_decreased_sensitivity_to1.19861583
60MP0005174_abnormal_tail_pigmentation1.18952738
61MP0006054_spinal_hemorrhage1.16098446
62MP0001851_eye_inflammation1.10969582
63MP0005164_abnormal_response_to1.10946335
64MP0008004_abnormal_stomach_pH1.07302612
65MP0002138_abnormal_hepatobiliary_system1.03891108
66MP0002019_abnormal_tumor_incidence1.02816097
67MP0003828_pulmonary_edema0.99472387
68MP0000343_altered_response_to0.97620434
69MP0003690_abnormal_glial_cell0.97484050
70MP0000569_abnormal_digit_pigmentation0.93693232
71MP0003045_fibrosis0.92753359
72MP0002998_abnormal_bone_remodeling0.90598805
73MP0005310_abnormal_salivary_gland0.90216614
74MP0004130_abnormal_muscle_cell0.87243954
75MP0003656_abnormal_erythrocyte_physiolo0.87234280
76MP0005058_abnormal_lysosome_morphology0.86621183
77MP0009763_increased_sensitivity_to0.84028177
78MP0003191_abnormal_cellular_cholesterol0.81686487
79MP0005023_abnormal_wound_healing0.78483041
80MP0005166_decreased_susceptibility_to0.76052455
81MP0003183_abnormal_peptide_metabolism0.75061247
82MP0009765_abnormal_xenobiotic_induced0.73686544
83MP0004484_altered_response_of0.73007561
84MP0000604_amyloidosis0.70230574
85MP0003279_aneurysm0.68942150
86MP0003453_abnormal_keratinocyte_physiol0.68587043
87MP0003795_abnormal_bone_structure0.65726170
88MP0001986_abnormal_taste_sensitivity0.64929508
89MP0003806_abnormal_nucleotide_metabolis0.64233507
90MP0002095_abnormal_skin_pigmentation0.63945619
91MP0003221_abnormal_cardiomyocyte_apopto0.62279924
92MP0003566_abnormal_cell_adhesion0.60957248
93MP0008874_decreased_physiological_sensi0.60806415
94MP0002332_abnormal_exercise_endurance0.59904509
95MP0003172_abnormal_lysosome_physiology0.58924980
96MP0000249_abnormal_blood_vessel0.58516970
97MP0010352_gastrointestinal_tract_polyps0.53606206
98MP0001191_abnormal_skin_condition0.53345899
99MP0001663_abnormal_digestive_system0.52521423
100MP0005390_skeleton_phenotype0.52430370
101MP0002136_abnormal_kidney_physiology0.52402278
102MP0000015_abnormal_ear_pigmentation0.51444949
103MP0002133_abnormal_respiratory_system0.51430651
104MP0005388_respiratory_system_phenotype0.51430651
105MP0003252_abnormal_bile_duct0.51305636
106MP0003943_abnormal_hepatobiliary_system0.50505093
107MP0002693_abnormal_pancreas_physiology0.49731440
108MP0000609_abnormal_liver_physiology0.48400635
109MP0002277_abnormal_respiratory_mucosa0.47773650
110MP0002928_abnormal_bile_duct0.47433064
111MP0005319_abnormal_enzyme/_coenzyme0.47350731
112MP0008057_abnormal_DNA_replication0.45860939
113MP0003075_altered_response_to0.45554504
114MP0000477_abnormal_intestine_morphology0.44934603
115MP0001243_abnormal_dermal_layer0.42494373
116MP0008058_abnormal_DNA_repair0.42410077
117MP0001216_abnormal_epidermal_layer0.42129642
118MP0008873_increased_physiological_sensi0.39799998
119MP0003077_abnormal_cell_cycle0.39722682
120MP0000313_abnormal_cell_death0.37687641
121MP0000598_abnormal_liver_morphology0.35401218

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.03959628
2Abnormality of T cell number (HP:0011839)5.78572943
3Recurrent abscess formation (HP:0002722)5.23693625
4Eczematoid dermatitis (HP:0000976)5.10908870
5Myositis (HP:0100614)5.04669924
6Elevated erythrocyte sedimentation rate (HP:0003565)4.59743749
7Abnormality of T cells (HP:0002843)4.49806416
8Recurrent fungal infections (HP:0002841)4.36507083
9Recurrent bacterial skin infections (HP:0005406)4.36164805
10Stomatitis (HP:0010280)4.30533821
11Chronic otitis media (HP:0000389)4.22102341
12IgM deficiency (HP:0002850)4.07879039
13Recurrent bronchitis (HP:0002837)4.07337696
14Recurrent viral infections (HP:0004429)4.04044123
15Pustule (HP:0200039)3.98575934
16Severe combined immunodeficiency (HP:0004430)3.83128095
17Combined immunodeficiency (HP:0005387)3.79089971
18Spontaneous hematomas (HP:0007420)3.73962482
19Nasal polyposis (HP:0100582)3.72578515
20Retrobulbar optic neuritis (HP:0100654)3.64429953
21Optic neuritis (HP:0100653)3.64429953
22Meningitis (HP:0001287)3.62495450
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.60053564
24Orchitis (HP:0100796)3.55357163
25Abnormality of the nasal mucosa (HP:0000433)3.50584340
26Panhypogammaglobulinemia (HP:0003139)3.50024737
27IgG deficiency (HP:0004315)3.45995886
28Mediastinal lymphadenopathy (HP:0100721)3.44904777
29Obstructive lung disease (HP:0006536)3.42003810
30Chronic obstructive pulmonary disease (HP:0006510)3.42003810
31Recurrent cutaneous fungal infections (HP:0011370)3.39876265
32Chronic mucocutaneous candidiasis (HP:0002728)3.39876265
33Encephalitis (HP:0002383)3.38416978
34Thrombocytosis (HP:0001894)3.35129837
35Recurrent skin infections (HP:0001581)3.32272081
36Hypochromic microcytic anemia (HP:0004840)3.25592331
37Inflammation of the large intestine (HP:0002037)3.24585661
38Recurrent gram-negative bacterial infections (HP:0005420)3.22851138
39Abnormality of eosinophils (HP:0001879)3.18172587
40Thyroiditis (HP:0100646)3.16720874
41Leukocytosis (HP:0001974)3.15447199
42Lymphopenia (HP:0001888)3.11835999
43Gastrointestinal inflammation (HP:0004386)3.11308657
44Abnormality of T cell physiology (HP:0011840)3.07828262
45Prolonged bleeding time (HP:0003010)3.05445777
46Autoimmune thrombocytopenia (HP:0001973)3.04817333
47Autoimmune hemolytic anemia (HP:0001890)3.04662702
48Episodic fever (HP:0001954)3.02762452
49Eosinophilia (HP:0001880)2.99990925
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.97928503
51Abnormality of macrophages (HP:0004311)2.92996268
52Vasculitis (HP:0002633)2.92719163
53Chronic diarrhea (HP:0002028)2.92577890
54Hypochromic anemia (HP:0001931)2.91649895
55Increased IgM level (HP:0003496)2.90247109
56Epistaxis (HP:0000421)2.89434984
57Peritonitis (HP:0002586)2.89038726
58Anorexia (HP:0002039)2.88428102
59Keratoconjunctivitis sicca (HP:0001097)2.83726655
60Hemoptysis (HP:0002105)2.81574048
61Abnormality of the fingertips (HP:0001211)2.81323040
62Agammaglobulinemia (HP:0004432)2.78581202
63Arterial thrombosis (HP:0004420)2.73363052
64Amyloidosis (HP:0011034)2.71549670
65Granulocytopenia (HP:0001913)2.71029744
66Petechiae (HP:0000967)2.68835887
67Pulmonary infiltrates (HP:0002113)2.67283747
68Gangrene (HP:0100758)2.67037584
69Cellulitis (HP:0100658)2.63106262
70Abnormal platelet volume (HP:0011876)2.56263381
71Keratoconjunctivitis (HP:0001096)2.54717760
72Recurrent sinusitis (HP:0011108)2.53089094
73Joint swelling (HP:0001386)2.51932122
74Verrucae (HP:0200043)2.51273582
75Papilloma (HP:0012740)2.51273582
76Abnormality of B cell number (HP:0010975)2.48948732
77B lymphocytopenia (HP:0010976)2.48948732
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46826604
79Increased IgE level (HP:0003212)2.45806064
80Pulmonary embolism (HP:0002204)2.45770821
81Gingivitis (HP:0000230)2.45721834
82Gingival bleeding (HP:0000225)2.45631736
83Hypergammaglobulinemia (HP:0010702)2.44404487
84Abnormality of the pleura (HP:0002103)2.43568213
85Colitis (HP:0002583)2.41107729
86Bronchitis (HP:0012387)2.40861368
87Osteomyelitis (HP:0002754)2.39089177
88Chest pain (HP:0100749)2.37358993
89IgA deficiency (HP:0002720)2.34737317
90Gastrointestinal infarctions (HP:0005244)2.30763590
91Acute hepatic failure (HP:0006554)2.29496363
92Glomerulopathy (HP:0100820)2.29495160
93Vertigo (HP:0002321)2.25689626
94Abnormality of the peritoneum (HP:0002585)2.25367586
95Chronic sinusitis (HP:0011109)2.24076829
96Abnormality of the endocardium (HP:0004306)2.23927562
97Lymphoma (HP:0002665)2.22101866
98Fatigue (HP:0012378)2.17265656
99Interstitial pulmonary disease (HP:0006530)2.16932040
100Hypoplasia of the thymus (HP:0000778)2.14839891
101Abnormality of the prostate (HP:0008775)2.12309922
102Vacuolated lymphocytes (HP:0001922)2.09100788
103Viral hepatitis (HP:0006562)2.06040353
104Periodontitis (HP:0000704)2.05357671
105Keratitis (HP:0000491)2.05179618
106Microcytic anemia (HP:0001935)2.01665552
107Skin ulcer (HP:0200042)2.01503090
108Purpura (HP:0000979)1.99545258
109Polyneuropathy (HP:0001271)1.98820413
110Increased mean platelet volume (HP:0011877)1.98101916
111Slow saccadic eye movements (HP:0000514)1.97245958
112Acne (HP:0001061)1.96877413
113Amaurosis fugax (HP:0100576)1.94241309
114Thrombophlebitis (HP:0004418)1.93341552
115Subacute progressive viral hepatitis (HP:0006572)1.92986048
116Abnormality of the pericardium (HP:0001697)1.89414778
117Skin rash (HP:0000988)1.87874255
118Aplastic anemia (HP:0001915)1.87471560
119Urticaria (HP:0001025)1.86626950
120Basal cell carcinoma (HP:0002671)1.86504307
121Hematochezia (HP:0002573)1.85124887
122Hepatosplenomegaly (HP:0001433)1.85046143
123Increased serum ferritin (HP:0003281)1.84927732
124Poikiloderma (HP:0001029)1.84087136
125Papilledema (HP:0001085)1.83292357
126Sepsis (HP:0100806)1.81372688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.46828827
2MAP4K15.07905196
3ITK3.06102029
4IRAK42.97793648
5ZAP702.90018758
6STK102.80283839
7JAK32.79482684
8TEC2.56519663
9BTK2.40918972
10TYK22.31818316
11IKBKE2.30018872
12CSK2.13655974
13NLK2.02074810
14GRK62.01782242
15PRPF4B1.92087319
16BLK1.90966288
17FGFR41.89527965
18JAK11.88539874
19MAP3K141.75867628
20TGFBR21.75758093
21LCK1.71426988
22SYK1.65526428
23TBK11.64832602
24FGR1.61038114
25KIT1.53893137
26HCK1.51846520
27CLK11.50264817
28TAOK11.41492895
29LRRK21.37109201
30FES1.31982760
31MAP3K111.30077722
32FGFR31.29686705
33KSR21.28906057
34FLT31.28478090
35MAP2K31.24783823
36YES11.22995524
37BMPR21.21815111
38MAP3K131.21128988
39IKBKB1.19523436
40MAP3K11.19237053
41PKN21.17963875
42EEF2K1.16022215
43MST41.13987812
44NME21.13470543
45SIK31.13260221
46CSF1R1.12948964
47PIM11.09593442
48KDR1.08636366
49TESK21.07879544
50EPHB11.07224736
51LYN1.07224681
52PIK3CG1.06694117
53MARK31.05434825
54PRKCQ0.96114928
55MAP3K20.94169070
56STK40.93886569
57MAP3K120.93550180
58MATK0.91865894
59TNK20.88992085
60TRPM70.88828971
61MAP3K60.88281650
62MAP3K100.87990809
63RPS6KA40.86196482
64JAK20.84629196
65MARK20.82224911
66TTN0.80408148
67PRKCH0.75341565
68RIPK10.72175760
69TAOK30.70220947
70PTK2B0.68879470
71IRAK30.68239405
72STK240.68018881
73TGFBR10.66085426
74PTK60.64707867
75MAP3K50.64040191
76RAF10.62944011
77TAOK20.61635054
78PDPK10.61576922
79IRAK10.61407936
80CDK190.60950791
81ERN10.60203583
82SIK20.59357557
83HIPK20.57853116
84CHUK0.57327073
85DYRK1B0.55481478
86SGK30.54899100
87MAP2K60.54072614
88EPHA30.53989778
89NUAK10.50626901
90STK110.50176110
91CDK90.48904234
92GRK70.48858316
93MAP3K70.48458716
94RET0.47428720
95PDK10.46853979
96RIPK40.44527960
97CAMKK10.44506952
98STK380.44368711
99TRIB30.42315074
100MAP2K40.41809429
101KSR10.40378046
102RPS6KA60.40326210
103PRKD20.39873794
104ACVR1B0.39515702
105MAPK110.38458347
106CDC42BPA0.38173623
107SGK20.37318473
108IGF1R0.37020943
109WNK10.36897378
110FYN0.36537349
111MYLK0.36483358
112CDK40.36222637
113MAPK40.34955935
114CAMKK20.34899396
115PDGFRB0.33833877
116BRSK20.33547348
117PRKG20.33542759
118RPS6KL10.32927302
119RPS6KC10.32927302
120MAPKAPK20.31806527
121ADRBK20.29588440
122PRKD10.29566177
123MELK0.29364876
124PRKCD0.29033903
125RPS6KB20.28884364
126DAPK20.27528890
127MAP3K30.27391636
128MAPK120.27282874
129SMG10.26536155
130IRAK20.26455935
131MAPK70.26407305
132CDK60.26026128
133MAP2K20.25727035
134DMPK0.25216686
135ABL10.24566398
136PASK0.24419119
137ALK0.23481484
138MAPK30.23078759

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.82290746
2Graft-versus-host disease_Homo sapiens_hsa053323.91959042
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.32310513
4T cell receptor signaling pathway_Homo sapiens_hsa046602.93377390
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.87782968
6Antigen processing and presentation_Homo sapiens_hsa046122.81357368
7Measles_Homo sapiens_hsa051622.60325290
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.58327457
9Leishmaniasis_Homo sapiens_hsa051402.57843664
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.45468613
11Hematopoietic cell lineage_Homo sapiens_hsa046402.27362946
12Allograft rejection_Homo sapiens_hsa053302.17694002
13Osteoclast differentiation_Homo sapiens_hsa043802.15571275
14B cell receptor signaling pathway_Homo sapiens_hsa046622.06751333
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84458729
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.74111760
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73095776
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.72396213
19Viral myocarditis_Homo sapiens_hsa054161.68941590
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60240787
21Staphylococcus aureus infection_Homo sapiens_hsa051501.59970159
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59153774
23Herpes simplex infection_Homo sapiens_hsa051681.57532172
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49791779
25Chemokine signaling pathway_Homo sapiens_hsa040621.46883052
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42853138
27Autoimmune thyroid disease_Homo sapiens_hsa053201.35869586
28Toxoplasmosis_Homo sapiens_hsa051451.34388045
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33892168
30Shigellosis_Homo sapiens_hsa051311.31907427
31Hepatitis B_Homo sapiens_hsa051611.24898717
32Pertussis_Homo sapiens_hsa051331.23895961
33Acute myeloid leukemia_Homo sapiens_hsa052211.23648473
34Platelet activation_Homo sapiens_hsa046111.22919572
35Tuberculosis_Homo sapiens_hsa051521.22181752
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19306944
37African trypanosomiasis_Homo sapiens_hsa051431.17944574
38Influenza A_Homo sapiens_hsa051641.16123369
39Ribosome_Homo sapiens_hsa030101.15124858
40Legionellosis_Homo sapiens_hsa051341.15044786
41Malaria_Homo sapiens_hsa051441.14664984
42TNF signaling pathway_Homo sapiens_hsa046681.09154476
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08390982
44Apoptosis_Homo sapiens_hsa042100.98934685
45Pancreatic cancer_Homo sapiens_hsa052120.98420725
46Type I diabetes mellitus_Homo sapiens_hsa049400.97285883
47Other glycan degradation_Homo sapiens_hsa005110.93371043
48Salmonella infection_Homo sapiens_hsa051320.93307154
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89229223
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85361776
51Hepatitis C_Homo sapiens_hsa051600.84230240
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83698198
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82512013
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82311007
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81237549
56Renal cell carcinoma_Homo sapiens_hsa052110.80201189
57Chronic myeloid leukemia_Homo sapiens_hsa052200.77658525
58Asthma_Homo sapiens_hsa053100.76999679
59HTLV-I infection_Homo sapiens_hsa051660.76944523
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76506298
61Dorso-ventral axis formation_Homo sapiens_hsa043200.74791891
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74662871
63Epstein-Barr virus infection_Homo sapiens_hsa051690.73954892
64Rheumatoid arthritis_Homo sapiens_hsa053230.72428632
65Caffeine metabolism_Homo sapiens_hsa002320.72324265
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69749553
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68477629
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68305676
69Prolactin signaling pathway_Homo sapiens_hsa049170.66999252
70Endometrial cancer_Homo sapiens_hsa052130.65589264
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.63077497
72Colorectal cancer_Homo sapiens_hsa052100.62762654
73Choline metabolism in cancer_Homo sapiens_hsa052310.61989632
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61149853
75Viral carcinogenesis_Homo sapiens_hsa052030.58071587
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55922719
77VEGF signaling pathway_Homo sapiens_hsa043700.55804703
78Non-small cell lung cancer_Homo sapiens_hsa052230.54984590
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.54435625
80GnRH signaling pathway_Homo sapiens_hsa049120.54359895
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54161165
82p53 signaling pathway_Homo sapiens_hsa041150.49039764
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48732892
84MAPK signaling pathway_Homo sapiens_hsa040100.48473984
85FoxO signaling pathway_Homo sapiens_hsa040680.47987749
86DNA replication_Homo sapiens_hsa030300.47072738
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.46899548
88Pentose phosphate pathway_Homo sapiens_hsa000300.44900755
89mTOR signaling pathway_Homo sapiens_hsa041500.44725326
90Lysosome_Homo sapiens_hsa041420.43301417
91Base excision repair_Homo sapiens_hsa034100.42961835
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.42753918
93Mismatch repair_Homo sapiens_hsa034300.41772110
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.41513055
95Small cell lung cancer_Homo sapiens_hsa052220.41248053
96Endocytosis_Homo sapiens_hsa041440.39950054
97Non-homologous end-joining_Homo sapiens_hsa034500.39625063
98Insulin resistance_Homo sapiens_hsa049310.38949583
99Type II diabetes mellitus_Homo sapiens_hsa049300.38284162
100Regulation of autophagy_Homo sapiens_hsa041400.37588623
101ErbB signaling pathway_Homo sapiens_hsa040120.35175482
102Notch signaling pathway_Homo sapiens_hsa043300.34471754
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34147898
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32955399
105ABC transporters_Homo sapiens_hsa020100.31804921
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.28101297
107Nucleotide excision repair_Homo sapiens_hsa034200.26926498
108Rap1 signaling pathway_Homo sapiens_hsa040150.25846418
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25251222
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24147302
111Inositol phosphate metabolism_Homo sapiens_hsa005620.22056247
112Thyroid cancer_Homo sapiens_hsa052160.21441013
113Phagosome_Homo sapiens_hsa041450.21327915
114RNA degradation_Homo sapiens_hsa030180.21318049
115Spliceosome_Homo sapiens_hsa030400.20017019
116Amoebiasis_Homo sapiens_hsa051460.19661017
117HIF-1 signaling pathway_Homo sapiens_hsa040660.18752300
118Focal adhesion_Homo sapiens_hsa045100.18223819
119Pathways in cancer_Homo sapiens_hsa052000.17081623
120Prostate cancer_Homo sapiens_hsa052150.17001755

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