TMEM72

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein which may be expressed specifically in the kidney. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyol transport (GO:0015791)9.82048843
2metanephric epithelium development (GO:0072207)9.44793338
3actin filament depolymerization (GO:0030042)8.85266266
4collecting duct development (GO:0072044)7.64386882
5nephron tubule development (GO:0072080)7.29898388
6negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.90585348
7cardiovascular system development (GO:0072358)6.74170823
8phosphate ion transport (GO:0006817)6.72798753
9renal absorption (GO:0070293)6.59986350
10mitotic metaphase plate congression (GO:0007080)6.57069581
11response to parathyroid hormone (GO:0071107)6.52785528
12renal tubule development (GO:0061326)6.49056021
13urate metabolic process (GO:0046415)6.25428768
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.14922971
15monoubiquitinated protein deubiquitination (GO:0035520)5.95207630
16nephron epithelium development (GO:0072009)5.91858829
17aminoglycoside antibiotic metabolic process (GO:0030647)5.87339860
18regulation of spindle organization (GO:0090224)5.78315094
19nuclear pore complex assembly (GO:0051292)5.63095637
20cell volume homeostasis (GO:0006884)5.46352375
21response to water (GO:0009415)5.29955970
22nuclear pore organization (GO:0006999)5.26427592
23metaphase plate congression (GO:0051310)5.23231879
24glomerular visceral epithelial cell development (GO:0072015)5.23123384
25regulation of retinoic acid receptor signaling pathway (GO:0048385)5.22993661
26regulation of mitotic spindle organization (GO:0060236)5.19919971
27phosphate ion homeostasis (GO:0055062)5.14052637
28trivalent inorganic anion homeostasis (GO:0072506)5.14052637
29mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.09099892
30nephron tubule formation (GO:0072079)4.99248188
31positive regulation of catenin import into nucleus (GO:0035413)4.99096436
32quaternary ammonium group transport (GO:0015697)4.96853511
33DNA replication checkpoint (GO:0000076)4.91516201
34regulation of apoptotic process involved in morphogenesis (GO:1902337)4.80564589
35negative regulation of metanephros development (GO:0072217)4.78130474
36regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.74299288
37mitotic sister chromatid segregation (GO:0000070)4.72769669
38response to lead ion (GO:0010288)4.72456344
39positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.68815118
40protein localization to kinetochore (GO:0034501)4.67193745
41microtubule depolymerization (GO:0007019)4.66552058
42activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.66141841
43glomerular epithelial cell development (GO:0072310)4.61583659
44regulation of RNA export from nucleus (GO:0046831)4.60291982
45mitotic chromosome condensation (GO:0007076)4.57192676
46inner cell mass cell proliferation (GO:0001833)4.53732354
47regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.51958415
48response to thyroid hormone (GO:0097066)4.51319487
49vitamin transmembrane transport (GO:0035461)4.51092998
50amino-acid betaine metabolic process (GO:0006577)4.49041101
51DNA damage response, signal transduction resulting in transcription (GO:0042772)4.48863680
52positive regulation of chromosome segregation (GO:0051984)4.48501042
53DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.45236699
54inositol metabolic process (GO:0006020)4.43213713
55protein K6-linked ubiquitination (GO:0085020)4.41670530
56negative regulation of sterol transport (GO:0032372)4.39573258
57negative regulation of cholesterol transport (GO:0032375)4.39573258
58protein localization to chromosome, centromeric region (GO:0071459)4.38823541
59negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.36318348
60positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)4.34577512
61sister chromatid cohesion (GO:0007062)4.27847885
62tricarboxylic acid metabolic process (GO:0072350)4.24857871
63pore complex assembly (GO:0046931)4.24708788
64sister chromatid segregation (GO:0000819)4.20003987
65regulation of meiosis I (GO:0060631)4.17239249
66mitotic sister chromatid cohesion (GO:0007064)4.13657159
67mitotic nuclear envelope disassembly (GO:0007077)4.12940060
68positive regulation of mitotic sister chromatid separation (GO:1901970)4.11087953
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.11087953
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.11087953
71sodium-independent organic anion transport (GO:0043252)4.11033180
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.10416753
73regulation of establishment of cell polarity (GO:2000114)4.08858991
74establishment of chromosome localization (GO:0051303)4.08856481
75oocyte maturation (GO:0001556)4.06704887
76sulfur compound transport (GO:0072348)4.06537870
77meiotic chromosome segregation (GO:0045132)4.06378413
78response to growth hormone (GO:0060416)4.05380721
79regulation of sister chromatid cohesion (GO:0007063)4.04208204
80pattern specification involved in kidney development (GO:0061004)4.00097006
81histone H2A monoubiquitination (GO:0035518)3.98972187
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.97203819
83regulation of exit from mitosis (GO:0007096)3.96792736
84sulfate transmembrane transport (GO:1902358)3.93534921
85regulation of histone H3-K27 methylation (GO:0061085)3.91128737
86membrane disassembly (GO:0030397)3.89042703
87nuclear envelope disassembly (GO:0051081)3.89042703
88cellular ketone body metabolic process (GO:0046950)3.85094158
89protein localization to chromosome (GO:0034502)3.84912981
90urogenital system development (GO:0001655)3.83494425
91regulation of protein localization to cell surface (GO:2000008)3.81546758
92response to magnesium ion (GO:0032026)3.79433390
93hyperosmotic response (GO:0006972)3.78943551
94regulation of chromosome segregation (GO:0051983)3.78934362
95cell differentiation involved in metanephros development (GO:0072202)3.77708366
96regulation of establishment or maintenance of cell polarity (GO:0032878)3.69367984
97indole-containing compound metabolic process (GO:0042430)3.67495918
98renal system process (GO:0003014)3.66353500
99regulation of nucleobase-containing compound transport (GO:0032239)3.65329762
100resolution of meiotic recombination intermediates (GO:0000712)3.61835808
101response to copper ion (GO:0046688)3.59770470
102spindle checkpoint (GO:0031577)3.59364165
103cellular response to ammonium ion (GO:0071242)3.58361063
104purine nucleobase biosynthetic process (GO:0009113)3.56659674
105histone lysine demethylation (GO:0070076)3.56185361
106male meiosis I (GO:0007141)3.54967742
107histone demethylation (GO:0016577)3.52181966
108meiosis I (GO:0007127)3.50226085
109chromosome segregation (GO:0007059)3.48505079
110sulfate transport (GO:0008272)3.47903467
111negative regulation of DNA-dependent DNA replication (GO:2000104)3.47763229
112bicarbonate transport (GO:0015701)3.45103722
113ketone body metabolic process (GO:1902224)3.44639678
114regulation of telomere maintenance via telomerase (GO:0032210)3.44123780
115snRNA transcription (GO:0009301)3.41639292
116negative regulation of histone methylation (GO:0031061)3.41424291
117response to UV-C (GO:0010225)3.41337335
118protein depolymerization (GO:0051261)3.39120557
119regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.38825731
120regulation of mesenchymal cell apoptotic process (GO:2001053)3.37779546
121reciprocal meiotic recombination (GO:0007131)3.37365940
122reciprocal DNA recombination (GO:0035825)3.37365940
123bone remodeling (GO:0046849)3.36521365
124regulation of potassium ion transmembrane transporter activity (GO:1901016)3.36022721
125negative regulation of hormone biosynthetic process (GO:0032353)3.35956304
126negative regulation of hormone metabolic process (GO:0032351)3.35956304
127negative regulation of DNA-templated transcription, elongation (GO:0032785)3.32131012
128negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.32131012
129response to vitamin A (GO:0033189)3.31576648
130negative regulation of fibroblast apoptotic process (GO:2000270)3.30782226
131kinetochore assembly (GO:0051382)3.25942435
132mesenchymal cell differentiation involved in kidney development (GO:0072161)3.25698359
133mesenchymal cell differentiation involved in renal system development (GO:2001012)3.25698359
134calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.24696136
135inorganic anion transport (GO:0015698)3.23581570
136water transport (GO:0006833)3.22389690
137protein dealkylation (GO:0008214)3.20611942
138protein demethylation (GO:0006482)3.20611942
139nucleobase biosynthetic process (GO:0046112)3.19590069
140attachment of spindle microtubules to kinetochore (GO:0008608)3.17960384
141kinetochore organization (GO:0051383)3.15035357
142regulation of hippo signaling (GO:0035330)3.14101396
143glycoside metabolic process (GO:0016137)3.13762711
144inorganic anion transmembrane transport (GO:0098661)3.13499569
145nuclear envelope organization (GO:0006998)3.11956328
146DNA replication-independent nucleosome assembly (GO:0006336)3.11493453
147DNA replication-independent nucleosome organization (GO:0034724)3.11493453
148regulation of centrosome cycle (GO:0046605)3.11398839
149regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11294246
150chloride transmembrane transport (GO:1902476)3.11049600
151positive regulation of heat generation (GO:0031652)3.10258864
152DNA replication-dependent nucleosome organization (GO:0034723)3.10181978
153DNA replication-dependent nucleosome assembly (GO:0006335)3.10181978
154regulation of anion transport (GO:0044070)3.10057474
155sodium ion homeostasis (GO:0055078)3.08917770
156regulation of fever generation (GO:0031620)3.08081913
157mitotic spindle checkpoint (GO:0071174)3.07602002
158pre-miRNA processing (GO:0031054)3.05166262
159mammary gland alveolus development (GO:0060749)3.04837861
160histone exchange (GO:0043486)3.03306306
161regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03037523
162phosphate ion transmembrane transport (GO:0035435)3.02576441
163meiotic cell cycle process (GO:1903046)3.01837369
164maturation of 5.8S rRNA (GO:0000460)3.00815205
165histone H3-K9 methylation (GO:0051567)2.99655497
166nucleus organization (GO:0006997)2.99275596
167positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.98806759
168regulation of transcription from RNA polymerase I promoter (GO:0006356)2.98806262
169paraxial mesoderm development (GO:0048339)2.97352360
170negative regulation of chromosome segregation (GO:0051985)2.96596469
171histone H2A ubiquitination (GO:0033522)2.96561979
172regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.96544900
173synaptonemal complex assembly (GO:0007130)2.95650223
174regulation of sister chromatid segregation (GO:0033045)2.95246856
175regulation of mitotic sister chromatid separation (GO:0010965)2.95246856
176regulation of mitotic sister chromatid segregation (GO:0033047)2.95246856
177positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.93665796
178chloride transport (GO:0006821)2.92263887
179mesonephros development (GO:0001823)2.90617848
180histone H3-K9 demethylation (GO:0033169)2.89516202
181chromatin assembly or disassembly (GO:0006333)2.89202554
182sodium ion transport (GO:0006814)2.86385210
183regulation of stem cell maintenance (GO:2000036)2.84696052
184ERK1 and ERK2 cascade (GO:0070371)2.84260415
185drug transmembrane transport (GO:0006855)2.82875006
186regulation of potassium ion transmembrane transport (GO:1901379)2.82596457
187fluid transport (GO:0042044)2.80138274
188regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.79606130
189S-adenosylmethionine metabolic process (GO:0046500)2.79474001
190opioid receptor signaling pathway (GO:0038003)2.79299590
191cellular sodium ion homeostasis (GO:0006883)2.75083912
192positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.74712462
193regulation of catenin import into nucleus (GO:0035412)2.74588607
194beta-amyloid metabolic process (GO:0050435)2.74373628
195positive regulation of glomerulus development (GO:0090193)2.73814157
196response to mercury ion (GO:0046689)14.6130305
197excretion (GO:0007588)11.2997753
198metanephric tubule development (GO:0072170)11.2110255
199metanephric nephron tubule development (GO:0072234)11.2110255
200metanephric nephron epithelium development (GO:0072243)10.2228078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.25126862
2FOXM1_23109430_ChIP-Seq_U2OS_Human7.42375903
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.28917934
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.08397077
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85674424
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.69424083
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.46413268
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.43054823
9AR_21909140_ChIP-Seq_LNCAP_Human2.97427315
10* KAP1_22055183_ChIP-Seq_ESCs_Mouse2.74679418
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50977019
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.49444506
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45056044
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.34796701
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.29477204
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.27059590
17NANOG_18555785_ChIP-Seq_MESCs_Mouse2.26632941
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.19800012
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14841789
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.02058731
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.01514834
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97589211
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.93778594
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91380800
25* DROSHA_22980978_ChIP-Seq_HELA_Human1.81250730
26EZH2_22144423_ChIP-Seq_EOC_Human1.79802060
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74990536
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.74462720
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72593919
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65779672
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64690483
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.61053562
33RXR_22108803_ChIP-Seq_LS180_Human1.61027068
34GBX2_23144817_ChIP-Seq_PC3_Human1.60327806
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59569490
36TAF15_26573619_Chip-Seq_HEK293_Human1.57529763
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.56735133
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55061405
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54777814
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54288325
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49941481
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48763921
43NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48697120
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.46876202
45CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44820532
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.43798351
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43499393
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.39417573
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.38682613
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37887735
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37748207
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37319810
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35969626
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35766254
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.34977507
56NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.34307384
57SMAD4_21799915_ChIP-Seq_A2780_Human1.34120141
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.33900783
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.33317124
60KDM5A_27292631_Chip-Seq_BREAST_Human1.32853551
61* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30979367
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.29533250
63* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28940781
64KAP1_27257070_Chip-Seq_ESCs_Mouse1.28443235
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27528870
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.26908261
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25993781
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25750390
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24110801
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.23578029
71ZNF274_21170338_ChIP-Seq_K562_Hela1.23536980
72AHR_22903824_ChIP-Seq_MCF-7_Human1.21652676
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21544432
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21223879
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21164291
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19747498
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.19745465
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19629106
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17886157
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17532394
81* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16853133
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15894542
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15007036
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14978840
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.14086681
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.14004903
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.13612584
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.13242758
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12359020
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12214029
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11800195
92* CDX2_22108803_ChIP-Seq_LS180_Human1.11225180
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09504111
94VDR_24787735_ChIP-Seq_THP-1_Human1.09304588
95GATA1_22025678_ChIP-Seq_K562_Human1.08904464
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.07110648
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06982181
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.06738719
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06732905
100* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05948582
101PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05725125
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05293117
103JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04290608
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04197910
105* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03916796
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03755995
107* CBP_21632823_ChIP-Seq_H3396_Human1.02509821
108NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02141528
109P300_19829295_ChIP-Seq_ESCs_Human1.02089987
110TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01251201
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00511716
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00278773
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.00269018
114RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98071421
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.97960017
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97698723
117* KDM2B_26808549_Chip-Seq_REH_Human0.97278986
118AR_25329375_ChIP-Seq_VCAP_Human0.97183680
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97041377
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96898198
121EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96861077
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96797165
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96777299
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96653036
125PHF8_20622853_ChIP-Seq_HELA_Human0.95966190
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95879350
127* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95536251
128RAC3_21632823_ChIP-Seq_H3396_Human0.95247018
129SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95108873
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95039807
131BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94910928
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94800406
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94800406
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94800406
135MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94647982
136SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93968327
137RING1B_27294783_Chip-Seq_ESCs_Mouse0.93762167
138TCF4_23295773_ChIP-Seq_U87_Human0.93507622
139* NFYA_21822215_ChIP-Seq_K562_Human0.93322871
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.93137717
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92670074
142POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91855865
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91771212
144CBP_20019798_ChIP-Seq_JUKART_Human0.91771212
145FOXA2_19822575_ChIP-Seq_HepG2_Human0.91685564
146KLF4_18555785_Chip-Seq_ESCs_Mouse0.91655691
147STAT3_23295773_ChIP-Seq_U87_Human0.91618191
148OCT1_27270436_Chip-Seq_PROSTATE_Human0.91511373
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91027117
150STAT3_18555785_Chip-Seq_ESCs_Mouse0.90978853
151* TCF4_22108803_ChIP-Seq_LS180_Human0.90925849
152JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90721256
153PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90353960
154TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90335674
155SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90208195
156CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90055833
157BP1_19119308_ChIP-ChIP_Hs578T_Human0.89808978
158GATA4_25053715_ChIP-Seq_YYC3_Human0.89468070
159SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88999240
160IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88855516
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.88833996
162SOX2_21211035_ChIP-Seq_LN229_Gbm0.88787504
163ISL1_27105846_Chip-Seq_CPCs_Mouse0.87929010
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.86891559
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86687149
166AR_19668381_ChIP-Seq_PC3_Human0.86634331
167E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85337095
168PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85158394
169FUS_26573619_Chip-Seq_HEK293_Human0.85129635
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83715835
171FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83668784
172RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83590536
173TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83292359
174ZNF263_19887448_ChIP-Seq_K562_Human0.82995321
175CIITA_25753668_ChIP-Seq_RAJI_Human0.82863382
176POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82043048
177TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81282231
178VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80029901
179TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78557959
180POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78557959
181POU5F1_16518401_ChIP-PET_MESCs_Mouse0.77082894
182VDR_23849224_ChIP-Seq_CD4+_Human0.77043431
183STAT3_18555785_ChIP-Seq_MESCs_Mouse0.75982055
184XRN2_22483619_ChIP-Seq_HELA_Human0.74088315
185POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.72808962
186KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.72397288
187SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72369099
188POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.70675421
189PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70142372
190* TBL1_22424771_ChIP-Seq_293T_Human0.69926984
191NANOG_16518401_ChIP-PET_MESCs_Mouse0.67975684
192MYC_22102868_ChIP-Seq_BL_Human0.67685866
193CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.67638036
194LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67045626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis9.40752596
2MP0001756_abnormal_urination5.26201044
3MP0003693_abnormal_embryo_hatching4.80279747
4MP0003111_abnormal_nucleus_morphology4.49985949
5MP0002138_abnormal_hepatobiliary_system4.22153974
6MP0010094_abnormal_chromosome_stability4.06111484
7MP0001765_abnormal_ion_homeostasis3.99009985
8MP0008057_abnormal_DNA_replication3.82933850
9MP0003077_abnormal_cell_cycle3.79964981
10MP0009643_abnormal_urine_homeostasis3.63456620
11MP0008961_abnormal_basal_metabolism3.41881718
12MP0005451_abnormal_body_composition3.27319161
13MP0010307_abnormal_tumor_latency3.23261893
14MP0004019_abnormal_vitamin_homeostasis2.96101018
15MP0008007_abnormal_cellular_replicative2.92709933
16MP0002136_abnormal_kidney_physiology2.84954637
17MP0004957_abnormal_blastocyst_morpholog2.83399570
18MP0000569_abnormal_digit_pigmentation2.80021733
19MP0005636_abnormal_mineral_homeostasis2.79901410
20MP0003252_abnormal_bile_duct2.76000908
21MP0003718_maternal_effect2.66492489
22MP0008058_abnormal_DNA_repair2.66192127
23MP0008877_abnormal_DNA_methylation2.66060605
24MP0002168_other_aberrant_phenotype2.56828253
25MP0005332_abnormal_amino_acid2.55280529
26MP0001730_embryonic_growth_arrest2.44706928
27MP0000350_abnormal_cell_proliferation2.32916507
28MP0002102_abnormal_ear_morphology2.19852315
29MP0002928_abnormal_bile_duct2.12634826
30MP0003123_paternal_imprinting2.09757613
31MP0001672_abnormal_embryogenesis/_devel2.07661187
32MP0005380_embryogenesis_phenotype2.07661187
33MP0005076_abnormal_cell_differentiation2.00470308
34MP0004043_abnormal_pH_regulation11.1195831
35MP0002084_abnormal_developmental_patter1.95360504
36MP0003300_gastrointestinal_ulcer1.93374852
37MP0003937_abnormal_limbs/digits/tail_de1.92272186
38MP0005670_abnormal_white_adipose1.89700982
39MP0002085_abnormal_embryonic_tissue1.83203528
40MP0000534_abnormal_ureter_morphology1.80637424
41MP0004185_abnormal_adipocyte_glucose1.78377253
42MP0008932_abnormal_embryonic_tissue1.77426204
43MP0002653_abnormal_ependyma_morphology1.77385902
44MP0003984_embryonic_growth_retardation1.75828480
45MP0002088_abnormal_embryonic_growth/wei1.70955959
46MP0001697_abnormal_embryo_size1.69893199
47MP0002210_abnormal_sex_determination1.67597011
48MP0005360_urolithiasis1.64795308
49MP0003045_fibrosis1.62840607
50MP0002086_abnormal_extraembryonic_tissu1.60307820
51MP0001929_abnormal_gametogenesis1.59951634
52MP0002396_abnormal_hematopoietic_system1.54320779
53MP0006292_abnormal_olfactory_placode1.54316431
54MP0002139_abnormal_hepatobiliary_system1.52297557
55MP0000462_abnormal_digestive_system1.43735459
56MP0000653_abnormal_sex_gland1.42652075
57MP0003121_genomic_imprinting1.42278485
58MP0000538_abnormal_urinary_bladder1.39347198
59MP0001145_abnormal_male_reproductive1.38939819
60MP0002080_prenatal_lethality1.37818411
61MP0003787_abnormal_imprinting1.37581959
62MP0004264_abnormal_extraembryonic_tissu1.37192590
63MP0001270_distended_abdomen1.34602777
64MP0000230_abnormal_systemic_arterial1.34022374
65MP0001119_abnormal_female_reproductive1.33813584
66MP0003699_abnormal_female_reproductive1.33256809
67MP0003890_abnormal_embryonic-extraembry1.31748192
68MP0001849_ear_inflammation1.27248800
69MP0003646_muscle_fatigue1.25607071
70MP0003011_delayed_dark_adaptation1.25594231
71MP0003786_premature_aging1.24871072
72MP0005408_hypopigmentation1.23540479
73MP0010386_abnormal_urinary_bladder1.21408913
74MP0009672_abnormal_birth_weight1.21364099
75MP0001958_emphysema1.20481410
76MP0004197_abnormal_fetal_growth/weight/1.20086567
77MP0000566_synostosis1.16375826
78MP0005220_abnormal_exocrine_pancreas1.15001554
79MP0005395_other_phenotype1.14499147
80MP0008260_abnormal_autophagy1.13712563
81MP0010234_abnormal_vibrissa_follicle1.12331460
82MP0005621_abnormal_cell_physiology1.12086601
83MP0002135_abnormal_kidney_morphology1.09970844
84MP0003935_abnormal_craniofacial_develop1.09666149
85MP0001545_abnormal_hematopoietic_system1.08540591
86MP0005397_hematopoietic_system_phenotyp1.08540591
87MP0000432_abnormal_head_morphology1.07993609
88MP0002877_abnormal_melanocyte_morpholog1.05919032
89MP0005666_abnormal_adipose_tissue1.03766361
90MP0000383_abnormal_hair_follicle1.02725573
91MP0003879_abnormal_hair_cell1.01773940
92MP0003938_abnormal_ear_development1.00786781
93MP0010678_abnormal_skin_adnexa0.98800090
94MP0008995_early_reproductive_senescence0.96970852
95MP0005647_abnormal_sex_gland0.96958262
96MP0008872_abnormal_physiological_respon0.96707394
97MP0000579_abnormal_nail_morphology0.96390931
98MP0009703_decreased_birth_body0.95922221
99MP0003698_abnormal_male_reproductive0.95463045
100MP0001661_extended_life_span0.94711626
101MP0000627_abnormal_mammary_gland0.94285247
102MP0003705_abnormal_hypodermis_morpholog0.93154745
103MP0004808_abnormal_hematopoietic_stem0.91353713
104MP0003755_abnormal_palate_morphology0.90588470
105MP0000313_abnormal_cell_death0.90491666
106MP0010352_gastrointestinal_tract_polyps0.90458973
107MP0000428_abnormal_craniofacial_morphol0.90263161
108MP0002161_abnormal_fertility/fecundity0.89361632
109MP0005535_abnormal_body_temperature0.88828579
110MP0000490_abnormal_crypts_of0.86426924
111MP0005384_cellular_phenotype0.85279141
112MP0002069_abnormal_eating/drinking_beha0.84785203
113MP0003119_abnormal_digestive_system0.84505333
114MP0003861_abnormal_nervous_system0.83995448
115MP0003959_abnormal_lean_body0.83705595
116MP0005257_abnormal_intraocular_pressure0.83387190
117MP0000747_muscle_weakness0.83261831
118MP0009278_abnormal_bone_marrow0.83192764
119MP0002019_abnormal_tumor_incidence0.82145169
120MP0005310_abnormal_salivary_gland0.81892481
121MP0001915_intracranial_hemorrhage0.80884066
122MP0003936_abnormal_reproductive_system0.76599936
123MP0002896_abnormal_bone_mineralization0.76522440
124MP0003115_abnormal_respiratory_system0.74657564
125MP0002249_abnormal_larynx_morphology0.74286959
126MP0000733_abnormal_muscle_development0.73942311
127MP0003221_abnormal_cardiomyocyte_apopto0.73777378
128MP0004885_abnormal_endolymph0.73582721
129MP0005365_abnormal_bile_salt0.72197260
130MP0001293_anophthalmia0.71681888
131MP0003567_abnormal_fetal_cardiomyocyte0.71129459
132MP0005375_adipose_tissue_phenotype0.69637282
133MP0000427_abnormal_hair_cycle0.68817800
134MP0003950_abnormal_plasma_membrane0.66771090
135MP0001879_abnormal_lymphatic_vessel0.65477196
136MP0002925_abnormal_cardiovascular_devel0.65299381
137MP0003878_abnormal_ear_physiology0.62236896
138MP0005377_hearing/vestibular/ear_phenot0.62236896
139MP0005187_abnormal_penis_morphology0.61809397
140MP0010368_abnormal_lymphatic_system0.56338402
141MP0003943_abnormal_hepatobiliary_system0.56211138
142MP0000678_abnormal_parathyroid_gland0.55392540
143MP0002971_abnormal_brown_adipose0.54943285
144MP0003941_abnormal_skin_development0.54185695
145MP0005584_abnormal_enzyme/coenzyme_acti0.53006438
146MP0005319_abnormal_enzyme/_coenzyme0.52402362
147MP0003183_abnormal_peptide_metabolism0.51934198
148MP0008004_abnormal_stomach_pH0.51882362
149MP0005410_abnormal_fertilization0.51629990
150MP0002118_abnormal_lipid_homeostasis0.50221225
151MP0003866_abnormal_defecation0.50070041
152MP0000026_abnormal_inner_ear0.49560964
153MP0003638_abnormal_response/metabolism_0.49506711
154MP0003953_abnormal_hormone_level0.49140634
155MP0001664_abnormal_digestion0.48261210
156MP0002009_preneoplasia0.48250594
157MP0001191_abnormal_skin_condition0.46500861
158MP0001963_abnormal_hearing_physiology0.46225693
159MP0005085_abnormal_gallbladder_physiolo0.45292160
160MP0000465_gastrointestinal_hemorrhage0.45191876
161MP0009642_abnormal_blood_homeostasis0.43211198
162MP0004215_abnormal_myocardial_fiber0.41760385
163MP0000003_abnormal_adipose_tissue0.37920561
164MP0005448_abnormal_energy_balance0.36947610
165MP0001663_abnormal_digestive_system0.35115435
166MP0000631_abnormal_neuroendocrine_gland0.34632234
167MP0002078_abnormal_glucose_homeostasis0.34516833
168MP0003795_abnormal_bone_structure0.34462771
169MP0003690_abnormal_glial_cell0.33859716
170MP0005253_abnormal_eye_physiology0.33558622
171MP0001731_abnormal_postnatal_growth0.32143876
172MP0000013_abnormal_adipose_tissue0.30952432
173MP0001784_abnormal_fluid_regulation0.30257222
174MP0001764_abnormal_homeostasis0.30016185
175MP0005551_abnormal_eye_electrophysiolog0.29154407
176MP0005381_digestive/alimentary_phenotyp0.28654567
177MP0000778_abnormal_nervous_system0.27285032
178MP0009780_abnormal_chondrocyte_physiolo0.26984647
179MP0001324_abnormal_eye_pigmentation0.26737892
180MP0003942_abnormal_urinary_system0.25008078
181MP0001485_abnormal_pinna_reflex0.24915230
182MP0008569_lethality_at_weaning0.24319007
183MP0009115_abnormal_fat_cell0.23517273
184MP0001502_abnormal_circadian_rhythm0.22105473
185MP0004085_abnormal_heartbeat0.21524069
186MP0010770_preweaning_lethality0.20833947
187MP0002082_postnatal_lethality0.20833947
188MP0000163_abnormal_cartilage_morphology0.20221113
189MP0001944_abnormal_pancreas_morphology0.19325207

Predicted human phenotypes

RankGene SetZ-score
1Hypomagnesemia (HP:0002917)9.03449446
2Abnormality of chloride homeostasis (HP:0011422)8.78578509
3Hyperaldosteronism (HP:0000859)8.21583428
4Abnormality of magnesium homeostasis (HP:0004921)7.64729790
5Renal salt wasting (HP:0000127)7.56193496
6Abnormality of renin-angiotensin system (HP:0000847)7.37444093
7Polyuria (HP:0000103)7.11636584
8Tetany (HP:0001281)6.59729824
9Alkalosis (HP:0001948)6.51613420
10Abnormal urine output (HP:0012590)6.00210608
11Hypokalemia (HP:0002900)5.86517569
12Abnormality of renal excretion (HP:0011036)5.50260753
13Chromosomal breakage induced by crosslinking agents (HP:0003221)5.43099997
14Polydipsia (HP:0001959)5.38256179
15Abnormal drinking behavior (HP:0030082)5.38256179
16Chromsome breakage (HP:0040012)5.18066744
17Abnormality of potassium homeostasis (HP:0011042)4.63934047
18Facial hemangioma (HP:0000329)4.56032173
19Abnormality of the labia minora (HP:0012880)4.50662524
20Birth length less than 3rd percentile (HP:0003561)4.41571854
21Hypercalciuria (HP:0002150)4.37345069
22Prostate neoplasm (HP:0100787)4.21436685
23Adrenal overactivity (HP:0002717)3.97210731
24Abnormality of sodium homeostasis (HP:0010931)3.94553982
25Impulsivity (HP:0100710)3.74101071
26Abnormality of chromosome stability (HP:0003220)3.72950749
27Aplasia/Hypoplasia of the uvula (HP:0010293)3.72161123
28Breast hypoplasia (HP:0003187)3.70449029
29Abnormality of the preputium (HP:0100587)3.68531546
30Meckel diverticulum (HP:0002245)3.63015661
31Hyponatremia (HP:0002902)3.53301350
32Abnormality of the fingertips (HP:0001211)3.53057245
33Proximal tubulopathy (HP:0000114)3.47139364
34Patellar aplasia (HP:0006443)3.44745007
35Papillary thyroid carcinoma (HP:0002895)3.42246214
36Abnormality of the ileum (HP:0001549)3.38249198
37Shawl scrotum (HP:0000049)3.38172645
38Generalized aminoaciduria (HP:0002909)3.31820405
39Ectopic kidney (HP:0000086)3.27897340
40Capillary hemangiomas (HP:0005306)3.27419308
41Aplasia/Hypoplasia of the patella (HP:0006498)3.20287781
42Oligodactyly (hands) (HP:0001180)3.10883500
43Sparse lateral eyebrow (HP:0005338)3.02382896
44Atrioventricular block (HP:0001678)2.99996425
45Tubular atrophy (HP:0000092)2.98666560
46Abnormality of fatty-acid metabolism (HP:0004359)2.80222240
47Oligodactyly (HP:0012165)2.79077321
48Prominent nose (HP:0000448)2.78396646
49Abnormality of the carotid arteries (HP:0005344)2.78038897
50Acute myeloid leukemia (HP:0004808)2.75520399
51Nephrocalcinosis (HP:0000121)2.71556577
52Carpal bone hypoplasia (HP:0001498)2.70598178
53Dehydration (HP:0001944)2.68239085
54Duodenal stenosis (HP:0100867)2.67065434
55Small intestinal stenosis (HP:0012848)2.67065434
56Generalized muscle weakness (HP:0003324)2.62772674
57Myelodysplasia (HP:0002863)2.60404266
58Clubbing of toes (HP:0100760)2.60063316
59Anal stenosis (HP:0002025)2.59954850
60Absent radius (HP:0003974)2.59789084
61Large eyes (HP:0001090)2.57455660
62Hypotension (HP:0002615)2.55741035
63Ependymoma (HP:0002888)2.55095962
64Breast aplasia (HP:0100783)2.54800694
65Heterotopia (HP:0002282)2.52553864
66Potter facies (HP:0002009)2.49732131
67Facial shape deformation (HP:0011334)2.49732131
68Long eyelashes (HP:0000527)2.49206332
69Increased purine levels (HP:0004368)2.46337676
70Hyperuricemia (HP:0002149)2.46337676
71Abnormality of purine metabolism (HP:0004352)2.45226697
72Aplasia involving forearm bones (HP:0009822)2.43770308
73Absent forearm bone (HP:0003953)2.43770308
74Short thumb (HP:0009778)2.38981621
75Cafe-au-lait spot (HP:0000957)2.38664647
76Overlapping toe (HP:0001845)2.37416923
77Urethral obstruction (HP:0000796)2.36714946
78Decreased circulating renin level (HP:0003351)2.33086068
79Aplasia/Hypoplasia of the breasts (HP:0010311)2.32387149
80Flat capital femoral epiphysis (HP:0003370)2.32098567
81Chondrocalcinosis (HP:0000934)2.26833858
82Abnormality of the astrocytes (HP:0100707)2.26646088
83Astrocytoma (HP:0009592)2.26646088
84Male infertility (HP:0003251)2.25568361
85Lip pit (HP:0100267)2.23872108
86Sandal gap (HP:0001852)2.23020038
87Neoplasm of the oral cavity (HP:0100649)2.22082627
88Delayed epiphyseal ossification (HP:0002663)2.20209373
89Hyperphosphaturia (HP:0003109)2.19871011
90Abnormality of Sharpey fibers (HP:0100685)2.16073781
91Abnormality of the duodenum (HP:0002246)2.13934053
92Abnormality of lateral ventricle (HP:0030047)2.09512987
93Sloping forehead (HP:0000340)2.05041367
94Supernumerary spleens (HP:0009799)2.04486267
95Abdominal situs inversus (HP:0003363)2.03926100
96Abnormality of abdominal situs (HP:0011620)2.03926100
97Acute lymphatic leukemia (HP:0006721)2.01283922
98Increased circulating renin level (HP:0000848)13.0417688
99Metabolic alkalosis (HP:0200114)12.0612059
100Hyperactive renin-angiotensin system (HP:0000841)11.6979603
101Hypokalemic alkalosis (HP:0001949)10.8095884
102Bone marrow hypocellularity (HP:0005528)1.99518818
103Abnormality of DNA repair (HP:0003254)1.98804433
104Volvulus (HP:0002580)1.97113200
105Complete atrioventricular canal defect (HP:0001674)1.96217645
106Abnormality of the hepatic vasculature (HP:0006707)1.93817978
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92235039
108Arteriovenous malformation (HP:0100026)1.91866819
109Anal atresia (HP:0002023)1.91194609
110Abnormality of chromosome segregation (HP:0002916)1.89771690
111Microglossia (HP:0000171)1.89163021
112Heart block (HP:0012722)1.87391640
113Tracheoesophageal fistula (HP:0002575)1.87335733
114High anterior hairline (HP:0009890)1.87215419
115Glioma (HP:0009733)1.84684925
116Thyroid carcinoma (HP:0002890)1.83339023
117Cystic hygroma (HP:0000476)1.83253062
118Hyperkalemia (HP:0002153)1.82058857
119Medulloblastoma (HP:0002885)1.81140363
120Abnormality of urine glucose concentration (HP:0011016)1.80282384
121Glycosuria (HP:0003076)1.80282384
122Abnormal urine phosphate concentration (HP:0012599)1.79752163
123Abnormality of the proximal phalanges of the hand (HP:0009834)1.77619061
124Adrenal hypoplasia (HP:0000835)1.77379704
125Microtia (HP:0008551)1.76086850
126Horseshoe kidney (HP:0000085)1.74841125
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.74626622
128Abnormality of the labia (HP:0000058)1.73729994
129Abnormality of the prostate (HP:0008775)1.72542878
130Aplasia/hypoplasia of the humerus (HP:0006507)1.72408093
131Delayed puberty (HP:0000823)1.72118962
132Focal segmental glomerulosclerosis (HP:0000097)1.72053950
133Azoospermia (HP:0000027)1.71878743
134Rickets (HP:0002748)1.71498877
135Absent thumb (HP:0009777)1.71406610
136Abnormal spermatogenesis (HP:0008669)1.71218960
137Choanal atresia (HP:0000453)1.71162244
138Proximal placement of thumb (HP:0009623)1.70553181
139Rib fusion (HP:0000902)1.70358834
140Abnormality of the renal medulla (HP:0100957)1.70106723
141Tubulointerstitial fibrosis (HP:0005576)1.69930479
142Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69391393
143Tetraplegia (HP:0002445)1.68965744
144Abnormal atrioventricular conduction (HP:0005150)1.68588729
145Oral leukoplakia (HP:0002745)1.68548970
146Short humerus (HP:0005792)1.65809665
147Ankle contracture (HP:0006466)1.65151684
148Deviation of the thumb (HP:0009603)1.65078570
149Entropion (HP:0000621)1.64449174
150Gout (HP:0001997)1.63762020
151Abnormality of macular pigmentation (HP:0008002)1.59115273
152Abnormality of nucleobase metabolism (HP:0010932)1.58236593
153Bicornuate uterus (HP:0000813)1.57163244
154Hypophosphatemia (HP:0002148)1.47449698
155Impaired platelet aggregation (HP:0003540)1.46461554
156Abnormal platelet function (HP:0011869)1.46461554
157Metaphyseal dysplasia (HP:0100255)1.45980285
158Neonatal onset (HP:0003623)1.44098217
159Chorioretinal atrophy (HP:0000533)1.37973779
160Glomerulosclerosis (HP:0000096)1.37440480
161Thin bony cortex (HP:0002753)1.35326912
162Enlarged epiphyses (HP:0010580)1.34953747
163Premature birth (HP:0001622)1.31078438
164Nephrolithiasis (HP:0000787)1.30474768
165Intellectual disability, moderate (HP:0002342)1.30163626
166Abnormal tarsal ossification (HP:0008369)1.29203666
167Abnormality of calcium-phosphate metabolism (HP:0100530)1.27912624
168Visceral angiomatosis (HP:0100761)1.23918637
169Metaphyseal cupping (HP:0003021)1.22894164
170Nephrogenic diabetes insipidus (HP:0009806)1.21256239
171Elevated alkaline phosphatase (HP:0003155)1.20130438
172Abnormality of alkaline phosphatase activity (HP:0004379)1.18663036
173Amelogenesis imperfecta (HP:0000705)1.18411329
174Abnormal enzyme/coenzyme activity (HP:0012379)1.17238883
175Choanal stenosis (HP:0000452)1.15948310
176Osteopenia (HP:0000938)1.15482014
177Paresthesia (HP:0003401)1.15011381
178Hip contracture (HP:0003273)1.14846386
179Enlarged kidneys (HP:0000105)1.09489780
180Lymphangioma (HP:0100764)1.09417788
181Hemangiomatosis (HP:0007461)1.08522369
182Hypothermia (HP:0002045)1.08487537
183Tubulointerstitial abnormality (HP:0001969)1.08130624
184Renal tubular acidosis (HP:0001947)1.07352035
185Abnormality of renal resorption (HP:0011038)1.02937653
186Polyhydramnios (HP:0001561)0.99046152
187Pigmentary retinal degeneration (HP:0001146)0.97340817
188Hypoplasia of the uterus (HP:0000013)0.95520401
189Persistence of primary teeth (HP:0006335)0.92348613
190Neonatal death (HP:0003811)0.91293524
191Congenital stationary night blindness (HP:0007642)0.91130187
192Abnormal foot bone ossification (HP:0010675)0.90463725
193Pancreatic cysts (HP:0001737)0.90033793
194Stage 5 chronic kidney disease (HP:0003774)0.89858080
195Thyroid-stimulating hormone excess (HP:0002925)0.88740786
196Vomiting (HP:0002013)0.87568182
197Bilateral sensorineural hearing impairment (HP:0008619)0.86477778
198Hyperphosphatemia (HP:0002905)0.84681654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR18.35114407
2LATS15.18300559
3CDK124.78675245
4LATS24.47767536
5STK38L3.55003417
6WNK43.53690365
7CDC73.29191798
8NEK23.25320804
9STK392.82953685
10STK32.51951086
11TTK2.30237391
12BUB12.23564617
13AKT32.15095262
14SGK4942.03241959
15SGK2232.03241959
16BRD41.96911585
17SRPK11.96807667
18BRSK21.92888482
19PLK41.89360527
20CHEK21.89011607
21ERBB41.88890264
22WEE11.82479694
23EEF2K1.81358498
24PLK11.76419036
25KSR21.76290255
26CAMK1D1.76242088
27STK381.60139206
28PAK61.49990695
29TAOK11.48971552
30RAF11.47199601
31AURKB1.38623992
32PLK31.37375753
33CHEK11.34536239
34MAP3K91.33567932
35MKNK21.31235638
36MAP3K61.25462517
37KSR11.22100799
38CDK71.21502704
39DYRK31.20025081
40CDK91.19683110
41MAPK151.19552519
42RIPK11.17810442
43ACVR1B1.16518987
44CAMK1G1.13481579
45BRSK11.11055068
46MELK1.10518755
47ATM1.08723367
48CDK41.06515510
49ATR1.01640384
50RPS6KB21.00484942
51MAPKAPK30.98770845
52BRAF0.93340293
53MST1R0.92721958
54MTOR0.91179776
55MUSK0.90933107
56STK40.90127464
57PRKAA10.88536272
58CAMKK20.88368900
59CDK20.87630921
60CDK30.86364998
61TAOK30.79206338
62MARK30.78434707
63TIE10.78004085
64VRK10.76048617
65TESK10.75347978
66BMPR1B0.73539408
67CDK80.71808337
68CDK10.70630354
69MAPK100.68706386
70PRKAA20.68129267
71NEK10.66553836
72EPHA20.64772722
73MKNK10.63479524
74ZAK0.62584110
75AURKA0.62340430
76PIK3CA0.61622553
77CDK190.58976442
78MAP3K80.58902900
79WNK10.58208861
80PDGFRB0.58097495
81PRKCI0.54951634
82MAP3K130.54650384
83FRK0.54456109
84RPS6KA40.51953223
85CSNK1D0.51918165
86SGK20.50401017
87PIM10.48768408
88LMTK20.47237777
89MARK20.45597104
90MAPK140.43990817
91DYRK20.43450263
92ALK0.43260378
93MET0.43252764
94CDK60.42922824
95SGK10.42545266
96GSK3B0.41994529
97MAP4K20.39277159
98ABL20.38089332
99NUAK10.37173194
100STK100.36066865
101ICK0.36041668
102CSNK1E0.35222098
103MAP3K70.35071305
104CSNK1A10.34973497
105PRKD30.34706822
106KDR0.33453463
107MAP2K10.32311104
108MAPK10.31767079
109EIF2AK20.31225259
110MAP4K10.30498962
111ABL10.30494798
112MAPK110.30023178
113SGK30.29919281
114PRKDC0.29868768
115AKT20.29289458
116TGFBR10.27983235
117PAK10.27960802
118TYRO30.27142416
119AKT10.27087550
120MAP3K40.26906857
121WNK30.26808902
122CAMKK10.23547629
123MAP3K50.23399088
124EIF2AK10.22982648
125MAP3K20.22709042
126EPHA40.22277833
127MAP3K110.22143656
128NEK60.21890732
129CHUK0.21841512
130JAK30.21580915
131TGFBR20.20593047
132PRKACG0.20327183
133GRK10.20087067
134DDR20.20056486
135PRKCZ0.18190763
136PDK10.16993329
137PDPK10.16827903
138STK110.16218773
139NTRK30.13073601
140ADRBK20.12810115
141BTK0.12510572
142BCKDK0.12145513
143BMX0.11491007
144ZAP700.11405011
145PIK3CG0.10982323
146EPHB20.10454176
147ERBB20.09404863
148PRKCB0.09221193
149TRIB30.09139460
150PRKACA0.08910117
151ADRBK10.08538933
152TNK20.07789774
153RPS6KA30.07677879
154LIMK10.07550886
155PRKCD0.06739619
156MAP2K20.06600811
157SRC0.06456268
158RIPK40.06114757
159PTK60.05629319
160CAMK40.04631616
161RPS6KA60.04481677
162CSNK1A1L0.03918293
163INSRR0.03578324
164CLK10.03206332
165MINK10.03153509
166PRKG20.02912746
167FGFR20.02087475
168PRKCA0.01883625
169ITK0.01656604
170MAPK30.01319498
171DAPK20.01019526
172LRRK20.00265876
173MATK-0.0103372
174CSK-0.0040947
175IKBKB-0.0037398
176MAP3K14-0.0036988
177SCYL2-0.0010308

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.73795873
2Vitamin B6 metabolism_Homo sapiens_hsa007504.48966671
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.36859261
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049604.17792016
5Nitrogen metabolism_Homo sapiens_hsa009104.03956818
6Cell cycle_Homo sapiens_hsa041103.70366595
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.57531961
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41681496
9Fanconi anemia pathway_Homo sapiens_hsa034603.16174852
10RNA polymerase_Homo sapiens_hsa030202.98556379
11RNA transport_Homo sapiens_hsa030132.84087459
12Basal transcription factors_Homo sapiens_hsa030222.74221906
13p53 signaling pathway_Homo sapiens_hsa041152.53734378
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52249273
15Homologous recombination_Homo sapiens_hsa034402.43704630
16Butanoate metabolism_Homo sapiens_hsa006502.38257030
17Collecting duct acid secretion_Homo sapiens_hsa049662.31838134
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15450751
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10598560
20Propanoate metabolism_Homo sapiens_hsa006402.08956941
21Bile secretion_Homo sapiens_hsa049762.04801541
22RNA degradation_Homo sapiens_hsa030182.04174829
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98600097
24Mineral absorption_Homo sapiens_hsa049781.96967464
25mRNA surveillance pathway_Homo sapiens_hsa030151.96924010
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.93871506
27Fatty acid biosynthesis_Homo sapiens_hsa000611.90718008
28Gastric acid secretion_Homo sapiens_hsa049711.89596176
29Oocyte meiosis_Homo sapiens_hsa041141.79552135
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.79418688
31Tryptophan metabolism_Homo sapiens_hsa003801.77927855
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73410448
33Phenylalanine metabolism_Homo sapiens_hsa003601.72714563
34Pentose phosphate pathway_Homo sapiens_hsa000301.71662725
35Fatty acid degradation_Homo sapiens_hsa000711.70200410
36MicroRNAs in cancer_Homo sapiens_hsa052061.68004867
37Histidine metabolism_Homo sapiens_hsa003401.64500380
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56644991
39Mismatch repair_Homo sapiens_hsa034301.55757171
40Lysine degradation_Homo sapiens_hsa003101.55691970
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51411343
42Non-homologous end-joining_Homo sapiens_hsa034501.49408380
43Spliceosome_Homo sapiens_hsa030401.46948148
44DNA replication_Homo sapiens_hsa030301.44398294
45Nucleotide excision repair_Homo sapiens_hsa034201.44034095
46Phototransduction_Homo sapiens_hsa047441.34615206
47One carbon pool by folate_Homo sapiens_hsa006701.32787276
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27807199
49beta-Alanine metabolism_Homo sapiens_hsa004101.23966683
50Retinol metabolism_Homo sapiens_hsa008301.23875423
51mTOR signaling pathway_Homo sapiens_hsa041501.22850521
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.19813108
53Circadian rhythm_Homo sapiens_hsa047101.18863113
54Small cell lung cancer_Homo sapiens_hsa052221.15990042
55TGF-beta signaling pathway_Homo sapiens_hsa043501.12767162
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11950487
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.11921634
58Herpes simplex infection_Homo sapiens_hsa051681.07506472
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05522517
60Vitamin digestion and absorption_Homo sapiens_hsa049771.04918893
61Dorso-ventral axis formation_Homo sapiens_hsa043201.04146994
62Pyrimidine metabolism_Homo sapiens_hsa002401.04011089
63Protein digestion and absorption_Homo sapiens_hsa049741.03717961
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03206837
65Arginine and proline metabolism_Homo sapiens_hsa003301.03034872
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02672722
67Viral carcinogenesis_Homo sapiens_hsa052031.02564363
68Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01746884
69Pancreatic cancer_Homo sapiens_hsa052120.98842648
70Inositol phosphate metabolism_Homo sapiens_hsa005620.95747105
71FoxO signaling pathway_Homo sapiens_hsa040680.95607167
72Starch and sucrose metabolism_Homo sapiens_hsa005000.95381723
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94659445
74Renin-angiotensin system_Homo sapiens_hsa046140.93918900
75Choline metabolism in cancer_Homo sapiens_hsa052310.93182877
76Epstein-Barr virus infection_Homo sapiens_hsa051690.91420026
77Renal cell carcinoma_Homo sapiens_hsa052110.89925529
78Base excision repair_Homo sapiens_hsa034100.89910491
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88671877
80PPAR signaling pathway_Homo sapiens_hsa033200.88094276
81Systemic lupus erythematosus_Homo sapiens_hsa053220.86981038
82Peroxisome_Homo sapiens_hsa041460.86315214
83Purine metabolism_Homo sapiens_hsa002300.86311655
84Folate biosynthesis_Homo sapiens_hsa007900.86054387
85Biosynthesis of amino acids_Homo sapiens_hsa012300.83168466
86Olfactory transduction_Homo sapiens_hsa047400.82947417
87Endometrial cancer_Homo sapiens_hsa052130.82854469
88Adherens junction_Homo sapiens_hsa045200.82407433
89Prolactin signaling pathway_Homo sapiens_hsa049170.80822031
90Prostate cancer_Homo sapiens_hsa052150.80354907
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80257973
92Colorectal cancer_Homo sapiens_hsa052100.79211378
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78763479
94Sulfur metabolism_Homo sapiens_hsa009200.78701441
95Fatty acid metabolism_Homo sapiens_hsa012120.76170732
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74377457
97Hippo signaling pathway_Homo sapiens_hsa043900.72111100
98Chronic myeloid leukemia_Homo sapiens_hsa052200.71925111
99Pancreatic secretion_Homo sapiens_hsa049720.71893416
100Chemical carcinogenesis_Homo sapiens_hsa052040.71008621
101Pyruvate metabolism_Homo sapiens_hsa006200.70687705
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68919790
103Notch signaling pathway_Homo sapiens_hsa043300.68395513
104Regulation of autophagy_Homo sapiens_hsa041400.67642554
105Fructose and mannose metabolism_Homo sapiens_hsa000510.67443922
106Ovarian steroidogenesis_Homo sapiens_hsa049130.64652530
107Hepatitis B_Homo sapiens_hsa051610.64627560
108Non-small cell lung cancer_Homo sapiens_hsa052230.63998892
109Carbon metabolism_Homo sapiens_hsa012000.61093828
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60215313
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.60094709
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59170466
113Influenza A_Homo sapiens_hsa051640.58962730
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58882799
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58623847
116Tight junction_Homo sapiens_hsa045300.56105155
117HTLV-I infection_Homo sapiens_hsa051660.55393445
118Thyroid cancer_Homo sapiens_hsa052160.54687023
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.53532452
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53094535
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.52618180
122Arachidonic acid metabolism_Homo sapiens_hsa005900.50582235
123ErbB signaling pathway_Homo sapiens_hsa040120.50010558
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.49008691
125Hepatitis C_Homo sapiens_hsa051600.47955681
126Thyroid hormone synthesis_Homo sapiens_hsa049180.46822670
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.46696530
128AMPK signaling pathway_Homo sapiens_hsa041520.46564308
129Linoleic acid metabolism_Homo sapiens_hsa005910.46391488
130Melanoma_Homo sapiens_hsa052180.46071206
131Type II diabetes mellitus_Homo sapiens_hsa049300.46013975
132Selenocompound metabolism_Homo sapiens_hsa004500.45512338
133Basal cell carcinoma_Homo sapiens_hsa052170.45247763
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45193079
135Glioma_Homo sapiens_hsa052140.43697928
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43624741
137GnRH signaling pathway_Homo sapiens_hsa049120.43602946
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43015872
139Pathways in cancer_Homo sapiens_hsa052000.42363418
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41372243
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41032323
142Renin secretion_Homo sapiens_hsa049240.40677938
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.40066153
144Axon guidance_Homo sapiens_hsa043600.39597915
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39178350
146Other glycan degradation_Homo sapiens_hsa005110.39028129
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.37785234
148Bladder cancer_Homo sapiens_hsa052190.36207246
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.35646602
150ABC transporters_Homo sapiens_hsa020100.34992052
151Sphingolipid metabolism_Homo sapiens_hsa006000.34542487
152Ether lipid metabolism_Homo sapiens_hsa005650.33484278
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.32697276
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31768006
155Drug metabolism - other enzymes_Homo sapiens_hsa009830.31458100
156VEGF signaling pathway_Homo sapiens_hsa043700.31176336
157Alcoholism_Homo sapiens_hsa050340.30246951
158Estrogen signaling pathway_Homo sapiens_hsa049150.30055391
159Insulin resistance_Homo sapiens_hsa049310.29269899
160Taste transduction_Homo sapiens_hsa047420.28673472
161Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28590665
162Wnt signaling pathway_Homo sapiens_hsa043100.28006618
163Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27988215
164Apoptosis_Homo sapiens_hsa042100.27399805
165Arginine biosynthesis_Homo sapiens_hsa002200.27096130
166Glucagon signaling pathway_Homo sapiens_hsa049220.26766524
167SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26274647
168NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26186394
169Glutathione metabolism_Homo sapiens_hsa004800.26181975
170Central carbon metabolism in cancer_Homo sapiens_hsa052300.26147960
171Complement and coagulation cascades_Homo sapiens_hsa046100.25569665
172Tyrosine metabolism_Homo sapiens_hsa003500.25310319
173Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25112155
174HIF-1 signaling pathway_Homo sapiens_hsa040660.23192943
175Salivary secretion_Homo sapiens_hsa049700.23005614
176Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21629166
177Gap junction_Homo sapiens_hsa045400.19719982
178Endocytosis_Homo sapiens_hsa041440.19354134
179Caffeine metabolism_Homo sapiens_hsa002320.17375166
180Metabolic pathways_Homo sapiens_hsa011000.15497574

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