TMEM74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.82686333
2synaptic vesicle exocytosis (GO:0016079)5.00787975
3retinal cone cell development (GO:0046549)4.96141125
4protein localization to synapse (GO:0035418)4.94370997
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.90185145
6presynaptic membrane assembly (GO:0097105)4.89697767
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76721758
8vocalization behavior (GO:0071625)4.74879259
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.67280459
10neurotransmitter-gated ion channel clustering (GO:0072578)4.60179951
11presynaptic membrane organization (GO:0097090)4.57989519
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.57842187
13regulation of synaptic vesicle exocytosis (GO:2000300)4.46319063
14neuronal action potential propagation (GO:0019227)4.45924190
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.34540641
16glutamate secretion (GO:0014047)4.31890901
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.30443532
18chromatin remodeling at centromere (GO:0031055)4.29103898
19synaptic vesicle maturation (GO:0016188)4.26980444
20postsynaptic membrane organization (GO:0001941)4.25836848
21locomotory exploration behavior (GO:0035641)4.25296836
22CENP-A containing nucleosome assembly (GO:0034080)4.24392130
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.16656856
24synaptic transmission, glutamatergic (GO:0035249)4.15046208
25cell migration in hindbrain (GO:0021535)4.14627295
26regulation of glutamate receptor signaling pathway (GO:1900449)4.13114630
27exploration behavior (GO:0035640)4.09763141
28gamma-aminobutyric acid transport (GO:0015812)4.06542157
29neuron-neuron synaptic transmission (GO:0007270)3.99392620
30neuron recognition (GO:0008038)3.99077713
31regulation of synaptic vesicle transport (GO:1902803)3.98828447
32innervation (GO:0060384)3.96015677
33startle response (GO:0001964)3.91123899
34glutamate receptor signaling pathway (GO:0007215)3.90267561
35DNA double-strand break processing (GO:0000729)3.89952859
36negative regulation of synaptic transmission, GABAergic (GO:0032229)3.84336874
37proline transport (GO:0015824)3.83492689
38regulation of neuronal synaptic plasticity (GO:0048168)3.81617139
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.80761753
40axonal fasciculation (GO:0007413)3.79431662
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.70700210
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.68106667
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66871583
44layer formation in cerebral cortex (GO:0021819)3.63781009
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60361775
46microtubule depolymerization (GO:0007019)3.55695109
47righting reflex (GO:0060013)3.54054147
48establishment of mitochondrion localization (GO:0051654)3.50186150
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46935701
50long-term synaptic potentiation (GO:0060291)3.46531971
51regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46063161
52histone exchange (GO:0043486)3.43877746
53regulation of synaptic plasticity (GO:0048167)3.40363893
54regulation of postsynaptic membrane potential (GO:0060078)3.40328231
55establishment of integrated proviral latency (GO:0075713)3.37654922
56positive regulation of membrane potential (GO:0045838)3.36828103
57neurotransmitter secretion (GO:0007269)3.36122948
58DNA replication-independent nucleosome organization (GO:0034724)3.32582235
59DNA replication-independent nucleosome assembly (GO:0006336)3.32582235
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.32411293
61dendritic spine morphogenesis (GO:0060997)3.30936816
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30007476
63positive regulation of synapse maturation (GO:0090129)3.28806746
64regulation of dendritic spine morphogenesis (GO:0061001)3.25614491
65behavioral fear response (GO:0001662)3.24380743
66behavioral defense response (GO:0002209)3.24380743
67negative regulation of dendrite morphogenesis (GO:0050774)3.17425373
68dendrite morphogenesis (GO:0048813)3.16227215
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16037808
70mitotic metaphase plate congression (GO:0007080)3.14641877
71negative regulation of dendrite development (GO:2000171)3.14022264
72synaptic vesicle endocytosis (GO:0048488)3.12689375
73pyrimidine nucleobase catabolic process (GO:0006208)3.10762102
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08652485
75DNA integration (GO:0015074)3.07114826
76negative regulation of DNA recombination (GO:0045910)3.06516365
77transmission of nerve impulse (GO:0019226)3.06464912
78adult walking behavior (GO:0007628)3.02896151
79regulation of synapse structural plasticity (GO:0051823)3.02617711
80dendrite development (GO:0016358)3.01526914
81regulation of neurotransmitter secretion (GO:0046928)3.01502598
82fear response (GO:0042596)3.01207281
83membrane depolarization (GO:0051899)3.00336962
84regulation of neuron projection regeneration (GO:0070570)3.00279922
85regulation of axon regeneration (GO:0048679)3.00279922
86positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98973203
87membrane depolarization during action potential (GO:0086010)2.98866715
88regulation of DNA methylation (GO:0044030)2.97965726
89central nervous system projection neuron axonogenesis (GO:0021952)2.97248455
90regulation of double-strand break repair via homologous recombination (GO:0010569)2.96583001
91negative regulation of neurotransmitter transport (GO:0051589)2.95962282
92learning (GO:0007612)2.95408658
93positive regulation of neurotransmitter secretion (GO:0001956)2.94675492
94protein localization to kinetochore (GO:0034501)2.94626868
95organelle transport along microtubule (GO:0072384)2.94611252
96serotonin receptor signaling pathway (GO:0007210)2.93795135
97regulation of synaptic transmission (GO:0050804)2.93405588
98synapse assembly (GO:0007416)2.93402465
99regulation of glutamate secretion (GO:0014048)2.92511020
100regulation of synaptic transmission, GABAergic (GO:0032228)2.92373656
101DNA damage response, detection of DNA damage (GO:0042769)2.92229283
102kinetochore assembly (GO:0051382)2.92138996
103histone H2A acetylation (GO:0043968)2.92005669
104cerebellar granule cell differentiation (GO:0021707)2.91600196
105positive regulation of synapse assembly (GO:0051965)2.88450844
106negative regulation of hormone biosynthetic process (GO:0032353)2.88033529
107negative regulation of hormone metabolic process (GO:0032351)2.88033529
108positive regulation of gastrulation (GO:2000543)2.87801296
109neuromuscular process (GO:0050905)2.87719622
110vesicle transport along microtubule (GO:0047496)2.87093650
111cochlea development (GO:0090102)2.86889948
112regulation of mitotic spindle checkpoint (GO:1903504)2.86652310
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86652310
114regulation of dendritic spine development (GO:0060998)2.85437910
115microtubule polymerization or depolymerization (GO:0031109)2.84724179
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83463147
117regulation of nuclear cell cycle DNA replication (GO:0033262)2.83252857
118neurotransmitter transport (GO:0006836)2.82938556
119long-term memory (GO:0007616)2.82848395
120response to histamine (GO:0034776)2.82367737
121paraxial mesoderm development (GO:0048339)2.81731819
122regulation of development, heterochronic (GO:0040034)2.80496467
123cerebral cortex radially oriented cell migration (GO:0021799)2.80047425
124regulation of respiratory system process (GO:0044065)2.79887478
125detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.79165666
126DNA replication-dependent nucleosome organization (GO:0034723)2.78261940
127DNA replication-dependent nucleosome assembly (GO:0006335)2.78261940
128telomere maintenance via telomerase (GO:0007004)2.77549070
129olfactory bulb development (GO:0021772)2.73149191
130somite rostral/caudal axis specification (GO:0032525)2.71453443
131protein-cofactor linkage (GO:0018065)2.71410754
132protein localization to chromosome (GO:0034502)2.71299578
133metaphase plate congression (GO:0051310)2.70800933
134nucleobase catabolic process (GO:0046113)2.70618838
135mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70289355
136mitochondrial respiratory chain complex I assembly (GO:0032981)2.70289355
137NADH dehydrogenase complex assembly (GO:0010257)2.70289355
138regulation of meiosis I (GO:0060631)2.69737193
139centriole replication (GO:0007099)2.66899872
140kinetochore organization (GO:0051383)2.63669680
141regulation of timing of cell differentiation (GO:0048505)2.63632194
142regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63218338
143mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.59300794
144ATP-dependent chromatin remodeling (GO:0043044)2.56952975
145meiotic cell cycle (GO:0051321)2.53851296
146DNA ligation (GO:0006266)2.51526498
147replication fork processing (GO:0031297)2.50217871
148DNA strand elongation involved in DNA replication (GO:0006271)2.47978088
149telomere maintenance via semi-conservative replication (GO:0032201)2.44941698
150somite development (GO:0061053)2.44457900
151DNA replication checkpoint (GO:0000076)2.44293887
152DNA strand elongation (GO:0022616)2.44158192
153sequestering of actin monomers (GO:0042989)2.43387550
154microtubule severing (GO:0051013)2.41147303
155spindle checkpoint (GO:0031577)2.39926319
156protein localization to chromosome, centromeric region (GO:0071459)2.38465125
157establishment of viral latency (GO:0019043)2.38295499
158negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.38272444
159negative regulation of translation, ncRNA-mediated (GO:0040033)2.38272444
160regulation of translation, ncRNA-mediated (GO:0045974)2.38272444
161intraciliary transport (GO:0042073)2.35974107
162telomere maintenance via telomere lengthening (GO:0010833)2.35448274
163mitotic chromosome condensation (GO:0007076)2.34697283
164negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.34500185
165negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.34500185
166negative regulation of mitotic sister chromatid segregation (GO:0033048)2.34500185
167negative regulation of mitotic sister chromatid separation (GO:2000816)2.34500185
168negative regulation of sister chromatid segregation (GO:0033046)2.34500185
169spliceosomal snRNP assembly (GO:0000387)2.32763427
170negative regulation of DNA-dependent DNA replication (GO:2000104)2.32482596
171nonmotile primary cilium assembly (GO:0035058)2.32456505
172cullin deneddylation (GO:0010388)2.31724127
173negative regulation of chromosome segregation (GO:0051985)2.30756928
174protein complex biogenesis (GO:0070271)2.30342822
175attachment of spindle microtubules to kinetochore (GO:0008608)2.29144136
176calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.27840193
177mitochondrial respiratory chain complex assembly (GO:0033108)2.27398631
178establishment of chromosome localization (GO:0051303)2.25806516
179regulation of helicase activity (GO:0051095)2.24158208
180negative regulation of telomere maintenance (GO:0032205)2.23955390
181histone mRNA metabolic process (GO:0008334)2.23954530
182nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.23009303
183transcription elongation from RNA polymerase III promoter (GO:0006385)2.22931687
184termination of RNA polymerase III transcription (GO:0006386)2.22931687
185primitive streak formation (GO:0090009)2.22383930
186nucleotide-excision repair, DNA gap filling (GO:0006297)2.22258592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.81706546
2GBX2_23144817_ChIP-Seq_PC3_Human4.61510361
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.84931655
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05915811
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96343118
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80567528
7E2F7_22180533_ChIP-Seq_HELA_Human2.80195709
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.77493882
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76852455
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70264175
11TAF15_26573619_Chip-Seq_HEK293_Human2.53897067
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51990387
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51990387
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.51704842
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49637586
16REST_21632747_ChIP-Seq_MESCs_Mouse2.45304531
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44965870
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37433335
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.33318230
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32514127
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27974747
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25433101
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24225914
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16660317
25AR_21572438_ChIP-Seq_LNCaP_Human2.14179813
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.13936475
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.12584732
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.10603576
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08725339
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.06482820
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05813101
32CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03977708
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03090319
34RARB_27405468_Chip-Seq_BRAIN_Mouse2.02239834
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01490312
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.99322406
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.97543711
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95764492
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94547114
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89591382
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.88736227
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.88587435
43P300_19829295_ChIP-Seq_ESCs_Human1.86962609
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83492720
45IGF1R_20145208_ChIP-Seq_DFB_Human1.81571223
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.79664079
47* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79430686
48DROSHA_22980978_ChIP-Seq_HELA_Human1.74771853
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.70546620
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66460177
51MYC_18940864_ChIP-ChIP_HL60_Human1.65988496
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65965068
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65858438
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63712754
55VDR_22108803_ChIP-Seq_LS180_Human1.60314464
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60252807
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.60180892
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60151721
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.58200206
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57423521
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.55700672
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55245134
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.54874882
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.54079623
65* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52998717
66ZNF274_21170338_ChIP-Seq_K562_Hela1.52583153
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52537861
68* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51833423
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.49164320
70FUS_26573619_Chip-Seq_HEK293_Human1.48801797
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47099439
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46661056
73AR_25329375_ChIP-Seq_VCAP_Human1.46243163
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45693210
75STAT3_23295773_ChIP-Seq_U87_Human1.45572728
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.44906756
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.43275668
78JUN_21703547_ChIP-Seq_K562_Human1.41693120
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41425589
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41230011
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.40809858
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39864222
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39412863
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39178939
85ELK1_19687146_ChIP-ChIP_HELA_Human1.38100205
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36973309
87RNF2_27304074_Chip-Seq_NSC_Mouse1.35062677
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33957728
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33407192
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30418502
91TCF4_23295773_ChIP-Seq_U87_Human1.29277433
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.27290504
93IRF1_19129219_ChIP-ChIP_H3396_Human1.27033607
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26168411
95ER_23166858_ChIP-Seq_MCF-7_Human1.24925395
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24288070
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23617007
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.23437145
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21488895
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.16762332
101TTF2_22483619_ChIP-Seq_HELA_Human1.16643683
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.16204960
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14884085
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14277621
105TP53_18474530_ChIP-ChIP_U2OS_Human1.12754910
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12690342
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11942298
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11854752
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.11732196
110HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11730378
111PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11181829
112* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10501329
113* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10341692
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.08983797
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08296173
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07908397
117FOXP3_21729870_ChIP-Seq_TREG_Human1.07738862
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07615024
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06966084
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06795552
121EWS_26573619_Chip-Seq_HEK293_Human1.05876193
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04623531
123NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04617765
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03916852
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03903662
126CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03372194
127P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03075274
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02820963
129* RUNX2_22187159_ChIP-Seq_PCA_Human1.02409593
130AHR_22903824_ChIP-Seq_MCF-7_Human1.01449341
131AR_19668381_ChIP-Seq_PC3_Human1.00318326
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99951274
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99951274
134CBP_20019798_ChIP-Seq_JUKART_Human0.98935765
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98935765
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98490490
137MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98413442
138MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98202359
139* KDM2B_26808549_Chip-Seq_REH_Human0.97789329
140PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97727455
141FLI1_27457419_Chip-Seq_LIVER_Mouse0.96737223
142STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95541978
143RING1B_27294783_Chip-Seq_ESCs_Mouse0.95188519
144TP53_22573176_ChIP-Seq_HFKS_Human0.94931901
145VDR_23849224_ChIP-Seq_CD4+_Human0.94770421
146FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94759592
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94752225
148PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94373118
149* SMAD4_21741376_ChIP-Seq_EPCs_Human0.94372532
150SOX9_26525672_Chip-Seq_HEART_Mouse0.94291324
151MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94160276
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.93675802
153* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93624535
154YY1_21170310_ChIP-Seq_MESCs_Mouse0.93471262
155AR_21909140_ChIP-Seq_LNCAP_Human0.91211027
156TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90222092
157E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90128017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.62156041
2MP0003880_abnormal_central_pattern5.24998598
3MP0004270_analgesia4.51317481
4MP0001968_abnormal_touch/_nociception3.68985912
5MP0003635_abnormal_synaptic_transmissio3.68298709
6MP0002736_abnormal_nociception_after3.50905801
7MP0002735_abnormal_chemical_nociception3.38668625
8MP0002063_abnormal_learning/memory/cond3.07125999
9MP0008789_abnormal_olfactory_epithelium3.02043660
10MP0009745_abnormal_behavioral_response2.99044326
11MP0002734_abnormal_mechanical_nocicepti2.85016818
12MP0002064_seizures2.70406867
13MP0009046_muscle_twitch2.63474052
14MP0003693_abnormal_embryo_hatching2.61415507
15MP0002272_abnormal_nervous_system2.58854877
16MP0002572_abnormal_emotion/affect_behav2.58001730
17MP0005423_abnormal_somatic_nervous2.57121080
18MP0003329_amyloid_beta_deposits2.47495484
19MP0003890_abnormal_embryonic-extraembry2.43212535
20MP0000778_abnormal_nervous_system2.42068839
21MP0001293_anophthalmia2.37722830
22MP0001486_abnormal_startle_reflex2.26943994
23MP0002733_abnormal_thermal_nociception2.26507080
24MP0010030_abnormal_orbit_morphology2.26302656
25MP0003718_maternal_effect2.23385650
26MP0001501_abnormal_sleep_pattern2.22476289
27MP0006276_abnormal_autonomic_nervous2.21383666
28MP0004858_abnormal_nervous_system2.12080073
29MP0001970_abnormal_pain_threshold2.09273392
30MP0002184_abnormal_innervation2.06475045
31MP0002067_abnormal_sensory_capabilities2.06008365
32MP0001529_abnormal_vocalization2.03746911
33MP0001440_abnormal_grooming_behavior2.02686484
34MP0008058_abnormal_DNA_repair1.85010749
35MP0003787_abnormal_imprinting1.70778888
36MP0000955_abnormal_spinal_cord1.67295662
37MP0003119_abnormal_digestive_system1.66560716
38MP0010094_abnormal_chromosome_stability1.65558982
39MP0002233_abnormal_nose_morphology1.65357734
40MP0004811_abnormal_neuron_physiology1.64691620
41MP0002234_abnormal_pharynx_morphology1.60487564
42MP0004924_abnormal_behavior1.58795558
43MP0005386_behavior/neurological_phenoty1.58795558
44MP0003937_abnormal_limbs/digits/tail_de1.56335420
45MP0002557_abnormal_social/conspecific_i1.52189229
46MP0001905_abnormal_dopamine_level1.52095801
47MP0003111_abnormal_nucleus_morphology1.52028419
48MP0003567_abnormal_fetal_cardiomyocyte1.51551811
49MP0004142_abnormal_muscle_tone1.50348691
50MP0000566_synostosis1.50149265
51MP0002882_abnormal_neuron_morphology1.49195373
52MP0002822_catalepsy1.48463448
53MP0008569_lethality_at_weaning1.47142079
54MP0000049_abnormal_middle_ear1.47130007
55MP0003077_abnormal_cell_cycle1.41840267
56MP0009780_abnormal_chondrocyte_physiolo1.40016784
57MP0008932_abnormal_embryonic_tissue1.39438095
58MP0005646_abnormal_pituitary_gland1.34732831
59MP0001986_abnormal_taste_sensitivity1.33461705
60MP0002066_abnormal_motor_capabilities/c1.33406879
61MP0004133_heterotaxia1.26013742
62MP0003879_abnormal_hair_cell1.25374117
63MP0001286_abnormal_eye_development1.24104810
64MP0000569_abnormal_digit_pigmentation1.23857380
65MP0002938_white_spotting1.23588593
66MP0004957_abnormal_blastocyst_morpholog1.22370802
67MP0003183_abnormal_peptide_metabolism1.21954114
68MP0000604_amyloidosis1.20936349
69MP0003136_yellow_coat_color1.18077210
70MP0004885_abnormal_endolymph1.14154833
71MP0001929_abnormal_gametogenesis1.13840183
72MP0002163_abnormal_gland_morphology1.12459091
73MP0002152_abnormal_brain_morphology1.12271845
74MP0002697_abnormal_eye_size1.10314509
75MP0004145_abnormal_muscle_electrophysio1.10197353
76MP0006072_abnormal_retinal_apoptosis1.08944859
77MP0003632_abnormal_nervous_system1.08708609
78MP0003755_abnormal_palate_morphology1.06797179
79MP0001188_hyperpigmentation1.04989198
80MP0003631_nervous_system_phenotype1.04898638
81MP0002210_abnormal_sex_determination1.04146389
82MP0000920_abnormal_myelination1.01573577
83MP0006292_abnormal_olfactory_placode1.00429345
84MP0002653_abnormal_ependyma_morphology0.99135740
85MP0005645_abnormal_hypothalamus_physiol0.98712350
86MP0002102_abnormal_ear_morphology0.97700526
87MP0005171_absent_coat_pigmentation0.97623296
88MP0002752_abnormal_somatic_nervous0.96928197
89MP0002229_neurodegeneration0.96847316
90MP0008057_abnormal_DNA_replication0.96689608
91MP0002751_abnormal_autonomic_nervous0.95822558
92MP0009379_abnormal_foot_pigmentation0.95454493
93MP0005253_abnormal_eye_physiology0.94949201
94MP0003633_abnormal_nervous_system0.94605032
95MP0005391_vision/eye_phenotype0.93410223
96MP0002160_abnormal_reproductive_system0.91774478
97MP0003634_abnormal_glial_cell0.91409145
98MP0000631_abnormal_neuroendocrine_gland0.90977212
99MP0002085_abnormal_embryonic_tissue0.90182883
100MP0001984_abnormal_olfaction0.90136782
101MP0002909_abnormal_adrenal_gland0.88755694
102MP0000653_abnormal_sex_gland0.88081550
103MP0002084_abnormal_developmental_patter0.87408133
104MP0004742_abnormal_vestibular_system0.84363306
105MP0003122_maternal_imprinting0.83809945
106MP0008877_abnormal_DNA_methylation0.83631094
107MP0002092_abnormal_eye_morphology0.83308149
108MP0001963_abnormal_hearing_physiology0.83034858
109MP0003698_abnormal_male_reproductive0.82976780
110MP0005187_abnormal_penis_morphology0.82626073
111MP0004484_altered_response_of0.82542311
112MP0000751_myopathy0.82265628
113MP0003315_abnormal_perineum_morphology0.82142653
114MP0002837_dystrophic_cardiac_calcinosis0.81854115
115MP0002111_abnormal_tail_morphology0.80492301
116MP0004085_abnormal_heartbeat0.79314479
117MP0001145_abnormal_male_reproductive0.78637119
118MP0000647_abnormal_sebaceous_gland0.78413659
119MP0008260_abnormal_autophagy0.77105013
120MP0005195_abnormal_posterior_eye0.76235965
121MP0002069_abnormal_eating/drinking_beha0.75001351
122MP0009697_abnormal_copulation0.74971688
123MP0001502_abnormal_circadian_rhythm0.74556574
124MP0002161_abnormal_fertility/fecundity0.74386772
125MP0005380_embryogenesis_phenotype0.74246100
126MP0001672_abnormal_embryogenesis/_devel0.74246100
127MP0003861_abnormal_nervous_system0.73284346
128MP0001664_abnormal_digestion0.71966935
129MP0010386_abnormal_urinary_bladder0.71111819
130MP0003646_muscle_fatigue0.71096744
131MP0008872_abnormal_physiological_respon0.69133557
132MP0005623_abnormal_meninges_morphology0.68723863
133MP0001485_abnormal_pinna_reflex0.67521108
134MP0001177_atelectasis0.67289628
135MP0005551_abnormal_eye_electrophysiolog0.67215498
136MP0005394_taste/olfaction_phenotype0.66605147
137MP0005499_abnormal_olfactory_system0.66605147
138MP0004215_abnormal_myocardial_fiber0.65806881
139MP0005379_endocrine/exocrine_gland_phen0.62868191
140MP0002876_abnormal_thyroid_physiology0.61444679
141MP0001299_abnormal_eye_distance/0.61154984
142MP0000026_abnormal_inner_ear0.58380144
143MP0003121_genomic_imprinting0.56188146
144MP0001943_abnormal_respiration0.55091485
145MP0008874_decreased_physiological_sensi0.54761687
146MP0003123_paternal_imprinting0.54220393
147MP0003938_abnormal_ear_development0.52835999
148MP0003690_abnormal_glial_cell0.48449734

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.81965966
2Myokymia (HP:0002411)5.53379025
3Atonic seizures (HP:0010819)4.93960689
4Epileptic encephalopathy (HP:0200134)4.58919990
5Focal seizures (HP:0007359)4.47082757
6Febrile seizures (HP:0002373)4.09770780
7Septo-optic dysplasia (HP:0100842)3.86476355
8Visual hallucinations (HP:0002367)3.64819265
9Supernumerary spleens (HP:0009799)3.45421937
10Progressive cerebellar ataxia (HP:0002073)3.40191369
11Hyperventilation (HP:0002883)3.39675362
12Supranuclear gaze palsy (HP:0000605)3.32574751
13Colon cancer (HP:0003003)3.30140689
14Absence seizures (HP:0002121)3.26463671
15Termporal pattern (HP:0011008)3.26330657
16Insidious onset (HP:0003587)3.26330657
17Abnormality of the corticospinal tract (HP:0002492)3.24540838
18Neurofibrillary tangles (HP:0002185)3.21839086
19Action tremor (HP:0002345)3.20147385
20Dialeptic seizures (HP:0011146)3.18268153
21Cerebral inclusion bodies (HP:0100314)3.18022006
22Diplopia (HP:0000651)3.14791903
23Abnormality of binocular vision (HP:0011514)3.14791903
24Optic nerve hypoplasia (HP:0000609)3.07694672
25Pheochromocytoma (HP:0002666)3.07016309
26Amblyopia (HP:0000646)3.03071606
27Impaired vibration sensation in the lower limbs (HP:0002166)2.99613704
28Broad-based gait (HP:0002136)2.93279851
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.83588123
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.83588123
31Generalized tonic-clonic seizures (HP:0002069)2.80941365
32Oligodactyly (hands) (HP:0001180)2.79123611
33Anophthalmia (HP:0000528)2.78386430
34Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.78138158
35Ankle clonus (HP:0011448)2.76348979
36Dysmetria (HP:0001310)2.74172538
37Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.70705630
38Fetal akinesia sequence (HP:0001989)2.68444175
39Scanning speech (HP:0002168)2.66910918
40Neuroendocrine neoplasm (HP:0100634)2.63771418
41Hyperglycinemia (HP:0002154)2.63414440
42Truncal ataxia (HP:0002078)2.63249488
43Sensory axonal neuropathy (HP:0003390)2.62035237
44Urinary bladder sphincter dysfunction (HP:0002839)2.61330382
45Excessive salivation (HP:0003781)2.59405690
46Drooling (HP:0002307)2.59405690
47Hemivertebrae (HP:0002937)2.54689855
48Medial flaring of the eyebrow (HP:0010747)2.53669935
49Absent septum pellucidum (HP:0001331)2.52613815
50Epileptiform EEG discharges (HP:0011182)2.52158771
51Urinary urgency (HP:0000012)2.51862862
52Genital tract atresia (HP:0001827)2.51675490
53Hepatoblastoma (HP:0002884)2.50405700
54Spastic gait (HP:0002064)2.44202545
55Poor eye contact (HP:0000817)2.42102891
56Pancreatic fibrosis (HP:0100732)2.41823961
57Gaze-evoked nystagmus (HP:0000640)2.41077682
58Hemiparesis (HP:0001269)2.38835595
59Abnormality of the labia minora (HP:0012880)2.37615591
60Oligodactyly (HP:0012165)2.37173313
61Anxiety (HP:0000739)2.36784673
62Increased serum pyruvate (HP:0003542)2.36354645
63Abnormality of glycolysis (HP:0004366)2.36354645
64Congenital primary aphakia (HP:0007707)2.36268958
65Rib fusion (HP:0000902)2.35572776
66Progressive inability to walk (HP:0002505)2.34430452
67Delusions (HP:0000746)2.34386699
68Abnormal eating behavior (HP:0100738)2.32467868
69Methylmalonic acidemia (HP:0002912)2.32458524
70Vaginal atresia (HP:0000148)2.32238972
71Absent speech (HP:0001344)2.30459393
72Retinal dysplasia (HP:0007973)2.28843702
73EEG with generalized epileptiform discharges (HP:0011198)2.27183817
74Depression (HP:0000716)2.25149626
75Dysdiadochokinesis (HP:0002075)2.23476877
76Pancreatic cysts (HP:0001737)2.22408822
77Specific learning disability (HP:0001328)2.21353649
78Median cleft lip (HP:0000161)2.21098553
79Polyphagia (HP:0002591)2.20990448
80Abnormality of the septum pellucidum (HP:0007375)2.20872425
81Sclerocornea (HP:0000647)2.20804260
82High anterior hairline (HP:0009890)2.20446034
83Bifid tongue (HP:0010297)2.19757666
84Acute necrotizing encephalopathy (HP:0006965)2.19573266
85Abnormal hair whorl (HP:0010721)2.18809266
86Maternal diabetes (HP:0009800)2.16880162
87Hypsarrhythmia (HP:0002521)2.16068405
88Abnormal lung lobation (HP:0002101)2.15905149
89Chromsome breakage (HP:0040012)2.15320620
90Inability to walk (HP:0002540)2.15253314
91Nephrogenic diabetes insipidus (HP:0009806)2.13958253
92Acute encephalopathy (HP:0006846)2.13500362
93Birth length less than 3rd percentile (HP:0003561)2.12633458
94Neoplasm of the peripheral nervous system (HP:0100007)2.10863065
95Ulnar claw (HP:0001178)2.10825150
96Intestinal atresia (HP:0011100)2.10197622
97Lower limb muscle weakness (HP:0007340)2.09301662
98Abnormal social behavior (HP:0012433)2.08681373
99Impaired social interactions (HP:0000735)2.08681373
100Mutism (HP:0002300)2.07071033
101Impulsivity (HP:0100710)2.06812120
102True hermaphroditism (HP:0010459)2.05863417
103Broad alveolar ridges (HP:0000187)2.05742706
104Torticollis (HP:0000473)2.05652180
105J-shaped sella turcica (HP:0002680)2.05475211
106Aplasia/Hypoplasia of the tongue (HP:0010295)2.04597025
107Hypoplasia of the brainstem (HP:0002365)2.03318864
108Aplasia/Hypoplasia of the brainstem (HP:0007362)2.03318864
109Impaired smooth pursuit (HP:0007772)2.02952982
110Limb dystonia (HP:0002451)2.02811555
111Volvulus (HP:0002580)2.01002011
112Impaired vibratory sensation (HP:0002495)2.00969128
113Neuronal loss in central nervous system (HP:0002529)1.99333472
114Anencephaly (HP:0002323)1.96985375
115Tubulointerstitial nephritis (HP:0001970)1.96962601
116Postaxial hand polydactyly (HP:0001162)1.96675513
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95910540
118Cerebral hypomyelination (HP:0006808)1.95897499
119Meckel diverticulum (HP:0002245)1.94775535
120Abnormality of abdominal situs (HP:0011620)1.92975365
121Abdominal situs inversus (HP:0003363)1.92975365
122Esotropia (HP:0000565)1.92375580
123Abnormality of chromosome stability (HP:0003220)1.92329079
124Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.91448994
125Papilledema (HP:0001085)1.91196918
126Genetic anticipation (HP:0003743)1.90852211
127Abnormality of the ileum (HP:0001549)1.90729205
128Occipital encephalocele (HP:0002085)1.88717769
129Preaxial hand polydactyly (HP:0001177)1.88550504
130Akinesia (HP:0002304)1.88155478
131Increased hepatocellular lipid droplets (HP:0006565)1.87607430
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.87501153
133Autoamputation (HP:0001218)1.87459500
134Micropenis (HP:0000054)1.87212477
135Fibular aplasia (HP:0002990)1.87091740
136Abnormal mitochondria in muscle tissue (HP:0008316)1.86756510
137Focal dystonia (HP:0004373)1.86730693
138Widely spaced teeth (HP:0000687)1.86395904
139Poor coordination (HP:0002370)1.85419093
140Incomplete penetrance (HP:0003829)1.84743259
141Bile duct proliferation (HP:0001408)1.84407657
142Abnormal biliary tract physiology (HP:0012439)1.84407657
143Postaxial foot polydactyly (HP:0001830)1.83460257
144Cortical dysplasia (HP:0002539)1.81718304
145Gait imbalance (HP:0002141)1.81162635
146Narrow nasal bridge (HP:0000446)1.79794874
147Aplasia/Hypoplasia of the sternum (HP:0006714)1.78772127
148Bradycardia (HP:0001662)1.78675652
149Aqueductal stenosis (HP:0002410)1.78369661
1503-Methylglutaconic aciduria (HP:0003535)1.77291491
151Hammertoe (HP:0001765)1.77150350
152Abnormality of pain sensation (HP:0010832)1.76864133
153Impaired pain sensation (HP:0007328)1.76864133
154Generalized myoclonic seizures (HP:0002123)1.76803953
155Amyotrophic lateral sclerosis (HP:0007354)1.76150948
156Split foot (HP:0001839)1.75767012
157Obstructive sleep apnea (HP:0002870)1.74306246
158Bradykinesia (HP:0002067)1.73641886
159Poor speech (HP:0002465)1.73392135
160Choroideremia (HP:0001139)1.73202244
161Failure to thrive in infancy (HP:0001531)1.72481458
162Mitochondrial inheritance (HP:0001427)1.71389368
163Triphalangeal thumb (HP:0001199)1.70664034
164Abnormality of glycine metabolism (HP:0010895)1.69498430
165Abnormality of serine family amino acid metabolism (HP:0010894)1.69498430
166Lissencephaly (HP:0001339)1.69166096
167Preaxial foot polydactyly (HP:0001841)1.68221360
168Gastrointestinal atresia (HP:0002589)1.67818765
169Lipid accumulation in hepatocytes (HP:0006561)1.67647722
170Progressive macrocephaly (HP:0004481)1.66841325
171Decreased testicular size (HP:0008734)1.65181536
172Bilateral microphthalmos (HP:0007633)1.65045062
173Shoulder girdle muscle weakness (HP:0003547)1.64626445
174Abnormality of midbrain morphology (HP:0002418)1.63594196
175Molar tooth sign on MRI (HP:0002419)1.63594196
176Methylmalonic aciduria (HP:0012120)1.63345437
177Abnormal ciliary motility (HP:0012262)1.61937690
178Broad foot (HP:0001769)1.60762092
179Breast aplasia (HP:0100783)1.59470973
180Ectopic kidney (HP:0000086)1.58918569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.76595883
2NTRK33.72676598
3CASK3.71785075
4MAP3K93.46585074
5EPHA43.15268399
6TRIM283.02083485
7MAP3K42.97931570
8BUB12.96585945
9MAP2K72.95355872
10WNK32.84988963
11MAP3K122.84334925
12SRPK12.82174605
13CDC72.76402311
14CDK192.53254902
15NTRK12.44897561
16MINK12.28083258
17TTK2.24172638
18ZAK2.18620701
19PLK22.07753207
20MUSK1.89233386
21PAK61.87696022
22KSR21.86289360
23LATS21.85411935
24VRK11.83178199
25MAPK131.81444303
26STK161.81432386
27PLK31.81081582
28DAPK11.71376357
29MAP2K41.70962944
30VRK21.70290040
31MKNK11.66849526
32DAPK21.62134684
33MKNK21.61502044
34OXSR11.58657545
35WEE11.57049442
36KSR11.54014827
37DYRK31.52448531
38NEK11.49204538
39ARAF1.48047877
40PNCK1.46067976
41RIPK41.45027125
42PRPF4B1.44665022
43BRSK21.39398141
44CSNK1G21.36775452
45NTRK21.35593347
46CDK51.31050446
47PLK11.27628635
48MAP3K61.26583542
49SGK2231.21408139
50SGK4941.21408139
51BCKDK1.20410666
52DYRK21.18981019
53GRK51.16669981
54CAMK2A1.15507327
55PBK1.15376475
56BMPR1B1.12122511
57PLK41.08615966
58CLK11.04683020
59PRKD31.02398268
60CCNB11.01782272
61NUAK11.01677726
62BMPR20.99116617
63FGR0.97292839
64CAMK2B0.96918148
65MAP3K130.96563527
66CSNK1G30.95936236
67CDK180.95731699
68PHKG20.95463934
69PHKG10.95463934
70PRKCG0.95220211
71BRAF0.92646864
72ERBB40.92543560
73STK380.92527044
74RET0.91681161
75CDK150.90088193
76TNIK0.89895948
77AURKA0.89349516
78CDK140.88112750
79SGK20.87949963
80PTK2B0.86209122
81CSNK1A1L0.84870352
82AURKB0.84743632
83CHEK20.84035085
84BCR0.83959799
85MARK20.81595124
86STK390.81098642
87FES0.81036430
88NEK20.78282477
89MAP4K20.77405693
90CDK11A0.77177268
91ATR0.75340718
92EPHB20.73725116
93CAMK40.72013319
94MAPKAPK50.71118986
95CAMK2D0.68694625
96RAF10.68126963
97LIMK10.66643091
98SIK30.66154771
99CAMKK10.65921459
100TAOK10.65682755
101MOS0.65409955
102SIK20.65186385
103UHMK10.64832741
104PKN10.62569622
105DYRK1A0.60417859
106PRKCE0.59162203
107ROCK20.58928288
108CSNK1E0.58515029
109ATM0.58195007
110CAMKK20.57813721
111LATS10.57667191
112STK30.56234886
113STK240.54763321
114CSNK1G10.54606053
115TLK10.54406783
116NME10.54335801
117AKT30.54333763
118TSSK60.52036092
119CSNK1D0.50856175
120CHEK10.50772163
121CDK20.50479160
122CDK10.50405384
123MAPKAPK30.50260926
124PRKCH0.49241300
125BRSK10.47058514
126PAK30.44207086
127SGK10.44079742
128SGK30.42336282
129RPS6KA40.41729572
130FER0.40347362
131PRKCZ0.39975866
132PDK40.38838167
133PDK30.38838167
134CDK70.38689981
135MAP3K50.38428866
136ADRBK10.37752712
137TIE10.37020930
138CDK80.36475007
139TYRO30.36317877
140RPS6KA20.36022928
141PDPK10.35285378
142ERBB30.34701228
143STK110.34353738
144PDK10.33708058
145PRKACB0.33573135
146STK38L0.32788200
147RPS6KA30.32721247
148CAMK10.32421238
149CSNK1A10.32389948
150MAPK100.31997402
151DYRK1B0.30949875
152PRKDC0.30824619
153CSNK2A20.30776580
154MAP2K10.29647613
155FYN0.29397767

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.06047834
2Synaptic vesicle cycle_Homo sapiens_hsa047213.46247543
3Mismatch repair_Homo sapiens_hsa034302.82561871
4Non-homologous end-joining_Homo sapiens_hsa034502.81849606
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80709816
6Circadian entrainment_Homo sapiens_hsa047132.62156042
7Glutamatergic synapse_Homo sapiens_hsa047242.62133083
8Long-term potentiation_Homo sapiens_hsa047202.61612345
9GABAergic synapse_Homo sapiens_hsa047272.49838678
10Olfactory transduction_Homo sapiens_hsa047402.44665627
11Morphine addiction_Homo sapiens_hsa050322.41878641
12Collecting duct acid secretion_Homo sapiens_hsa049662.34462018
13Basal transcription factors_Homo sapiens_hsa030222.34456151
14Dopaminergic synapse_Homo sapiens_hsa047282.22878919
15DNA replication_Homo sapiens_hsa030302.22163089
16Amphetamine addiction_Homo sapiens_hsa050312.09939179
17RNA polymerase_Homo sapiens_hsa030202.09483038
18Taste transduction_Homo sapiens_hsa047422.09368815
19Salivary secretion_Homo sapiens_hsa049702.06852468
20Homologous recombination_Homo sapiens_hsa034402.03732842
21Serotonergic synapse_Homo sapiens_hsa047262.02936458
22Long-term depression_Homo sapiens_hsa047301.97322831
23Cell cycle_Homo sapiens_hsa041101.97057822
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90437828
25Cholinergic synapse_Homo sapiens_hsa047251.83270399
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.81542987
27Spliceosome_Homo sapiens_hsa030401.81217300
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80296655
29RNA degradation_Homo sapiens_hsa030181.80231815
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78395456
31Base excision repair_Homo sapiens_hsa034101.78110948
32RNA transport_Homo sapiens_hsa030131.76278417
33Fanconi anemia pathway_Homo sapiens_hsa034601.76084723
34Propanoate metabolism_Homo sapiens_hsa006401.75192860
35Protein export_Homo sapiens_hsa030601.70718101
36Proteasome_Homo sapiens_hsa030501.68993069
37Axon guidance_Homo sapiens_hsa043601.62893825
38Insulin secretion_Homo sapiens_hsa049111.61040886
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55136157
40Renin secretion_Homo sapiens_hsa049241.54197038
41Nucleotide excision repair_Homo sapiens_hsa034201.54100963
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53407759
43Calcium signaling pathway_Homo sapiens_hsa040201.52531333
44Gastric acid secretion_Homo sapiens_hsa049711.50506615
45Vibrio cholerae infection_Homo sapiens_hsa051101.49623602
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46601486
47Steroid biosynthesis_Homo sapiens_hsa001001.43796788
48Oxytocin signaling pathway_Homo sapiens_hsa049211.40507614
49Ribosome_Homo sapiens_hsa030101.40010349
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39179324
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38920952
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37708192
53Folate biosynthesis_Homo sapiens_hsa007901.37222123
54GnRH signaling pathway_Homo sapiens_hsa049121.35290520
55Cocaine addiction_Homo sapiens_hsa050301.35054306
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32926711
57Gap junction_Homo sapiens_hsa045401.32259569
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30897523
59mRNA surveillance pathway_Homo sapiens_hsa030151.27263093
60Oocyte meiosis_Homo sapiens_hsa041141.26227270
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22937000
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19050060
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16010130
64cAMP signaling pathway_Homo sapiens_hsa040241.12114402
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09551339
66Pyrimidine metabolism_Homo sapiens_hsa002401.07930488
67Purine metabolism_Homo sapiens_hsa002301.07484037
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07321042
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03674457
70Glioma_Homo sapiens_hsa052141.03226606
71ErbB signaling pathway_Homo sapiens_hsa040121.02912894
72Pyruvate metabolism_Homo sapiens_hsa006201.02403071
73Melanogenesis_Homo sapiens_hsa049161.01233073
74Oxidative phosphorylation_Homo sapiens_hsa001900.98452033
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97873538
76Estrogen signaling pathway_Homo sapiens_hsa049150.95121340
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94826525
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91939871
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89612168
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88734297
81Basal cell carcinoma_Homo sapiens_hsa052170.87688203
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87030727
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.85938305
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85801768
85Phototransduction_Homo sapiens_hsa047440.84421538
86Dorso-ventral axis formation_Homo sapiens_hsa043200.84324144
87Biosynthesis of amino acids_Homo sapiens_hsa012300.83506718
88Alzheimers disease_Homo sapiens_hsa050100.83248062
89Ras signaling pathway_Homo sapiens_hsa040140.81167211
90Ovarian steroidogenesis_Homo sapiens_hsa049130.78585597
91Fatty acid elongation_Homo sapiens_hsa000620.78470706
92p53 signaling pathway_Homo sapiens_hsa041150.78027989
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77617635
94Arginine and proline metabolism_Homo sapiens_hsa003300.76812759
95MAPK signaling pathway_Homo sapiens_hsa040100.75901765
96Type II diabetes mellitus_Homo sapiens_hsa049300.75714118
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72917085
98Hippo signaling pathway_Homo sapiens_hsa043900.71070865
99Cardiac muscle contraction_Homo sapiens_hsa042600.71035894
100Butanoate metabolism_Homo sapiens_hsa006500.70841147
101Choline metabolism in cancer_Homo sapiens_hsa052310.69362494
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.67772434
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65868272
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65184101
105Rap1 signaling pathway_Homo sapiens_hsa040150.64415338
106Colorectal cancer_Homo sapiens_hsa052100.63532124
107Pancreatic secretion_Homo sapiens_hsa049720.62898231
108Carbon metabolism_Homo sapiens_hsa012000.62762377
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62373651
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.61910030
111Metabolic pathways_Homo sapiens_hsa011000.58851148
112Wnt signaling pathway_Homo sapiens_hsa043100.58407192
113One carbon pool by folate_Homo sapiens_hsa006700.58094540
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.56396705
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56115476
116Phagosome_Homo sapiens_hsa041450.55460728
117Circadian rhythm_Homo sapiens_hsa047100.54871396
118Selenocompound metabolism_Homo sapiens_hsa004500.54560143
119Rheumatoid arthritis_Homo sapiens_hsa053230.53370753
120Melanoma_Homo sapiens_hsa052180.51517023
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51492998
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50813388
123Renal cell carcinoma_Homo sapiens_hsa052110.49209011
124Regulation of autophagy_Homo sapiens_hsa041400.48493083
125Parkinsons disease_Homo sapiens_hsa050120.47727582
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46974147
127TGF-beta signaling pathway_Homo sapiens_hsa043500.46874305
128VEGF signaling pathway_Homo sapiens_hsa043700.45970671
129Thyroid hormone synthesis_Homo sapiens_hsa049180.45969225
130Alcoholism_Homo sapiens_hsa050340.45954911
131Ether lipid metabolism_Homo sapiens_hsa005650.45404022
132Caffeine metabolism_Homo sapiens_hsa002320.44713979
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43741897
134Huntingtons disease_Homo sapiens_hsa050160.43274771
135Dilated cardiomyopathy_Homo sapiens_hsa054140.43128423
136Endometrial cancer_Homo sapiens_hsa052130.41988900
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.41442240
138Sulfur relay system_Homo sapiens_hsa041220.41424872
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36653119
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35798662
141Retinol metabolism_Homo sapiens_hsa008300.35293656
142Glucagon signaling pathway_Homo sapiens_hsa049220.35172196
143Inositol phosphate metabolism_Homo sapiens_hsa005620.34946829
144beta-Alanine metabolism_Homo sapiens_hsa004100.33872265
145Hedgehog signaling pathway_Homo sapiens_hsa043400.33550501
146Endocytosis_Homo sapiens_hsa041440.32979846
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32575920
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31458137
149Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28675046
150Pancreatic cancer_Homo sapiens_hsa052120.27809530
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27479018
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27005634
153Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25753460
154Salmonella infection_Homo sapiens_hsa051320.25592733
155Vitamin B6 metabolism_Homo sapiens_hsa007500.25454571
156Tight junction_Homo sapiens_hsa045300.25152077
157Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24260943

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