TMEM74B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.98185556
2lung epithelium development (GO:0060428)5.21447012
3neuron cell-cell adhesion (GO:0007158)5.03503093
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.94453968
5vocalization behavior (GO:0071625)4.78697227
6regulation of glutamate receptor signaling pathway (GO:1900449)4.77832898
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.71311628
8exploration behavior (GO:0035640)4.60696506
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.58720442
10behavioral response to nicotine (GO:0035095)4.58618429
11pyrimidine nucleobase catabolic process (GO:0006208)4.52413653
12synaptic vesicle exocytosis (GO:0016079)4.50645564
13protein localization to synapse (GO:0035418)4.35285611
14kidney morphogenesis (GO:0060993)4.33283804
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29145237
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24254341
17ATP synthesis coupled proton transport (GO:0015986)4.19180734
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19180734
19neuron recognition (GO:0008038)4.14179012
20auditory behavior (GO:0031223)4.10877478
21regulation of synaptic vesicle exocytosis (GO:2000300)3.96107649
22response to pheromone (GO:0019236)3.92219493
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.90889980
24collecting duct development (GO:0072044)3.90642277
25layer formation in cerebral cortex (GO:0021819)3.89065509
26nucleobase catabolic process (GO:0046113)3.83322093
27glutamate secretion (GO:0014047)3.80225834
28synaptic vesicle maturation (GO:0016188)3.76978622
29cell migration in hindbrain (GO:0021535)3.71550194
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.65897897
31neuronal action potential propagation (GO:0019227)3.64019547
32neuron-neuron synaptic transmission (GO:0007270)3.63207585
33axon ensheathment in central nervous system (GO:0032291)3.61846605
34central nervous system myelination (GO:0022010)3.61846605
35glutamate receptor signaling pathway (GO:0007215)3.57773408
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.56685810
37axonal fasciculation (GO:0007413)3.56033706
38negative regulation of microtubule polymerization (GO:0031115)3.53763989
39dendritic spine morphogenesis (GO:0060997)3.53620270
40regulation of synapse maturation (GO:0090128)3.52944024
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50610815
42neurotransmitter secretion (GO:0007269)3.46910077
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.45451957
44activation of protein kinase A activity (GO:0034199)3.45156716
45metanephric tubule development (GO:0072170)3.43907456
46metanephric nephron tubule development (GO:0072234)3.43907456
47synaptic transmission, glutamatergic (GO:0035249)3.41388577
48positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40974813
49regulation of synaptic vesicle transport (GO:1902803)3.38731925
50transmission of nerve impulse (GO:0019226)3.32747668
51long-term memory (GO:0007616)3.31523680
52positive regulation of synapse assembly (GO:0051965)3.27025002
53postsynaptic membrane organization (GO:0001941)3.26411698
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26399096
55dendrite morphogenesis (GO:0048813)3.21051797
56negative regulation of norepinephrine secretion (GO:0010700)3.20878339
57cell communication by electrical coupling (GO:0010644)3.16209013
58metanephric nephron epithelium development (GO:0072243)3.11700547
59establishment of mitochondrion localization (GO:0051654)3.11653726
60respiratory electron transport chain (GO:0022904)3.10320409
61proline transport (GO:0015824)3.07947343
62response to histamine (GO:0034776)3.06935667
63positive regulation of synapse maturation (GO:0090129)3.06771220
64startle response (GO:0001964)3.06135175
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.05431352
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05326616
67somite development (GO:0061053)3.04226157
68electron transport chain (GO:0022900)3.02507509
69neuronal ion channel clustering (GO:0045161)3.01585936
70regulation of long-term neuronal synaptic plasticity (GO:0048169)3.01358057
71regulation of neuronal synaptic plasticity (GO:0048168)3.01194617
72regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.01157294
73mechanosensory behavior (GO:0007638)3.00933165
74regulation of synapse structural plasticity (GO:0051823)2.98948264
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96282198
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95501156
77neurotransmitter-gated ion channel clustering (GO:0072578)2.95305629
78respiratory tube development (GO:0030323)2.94879125
79metanephric epithelium development (GO:0072207)2.94830568
80presynaptic membrane assembly (GO:0097105)2.93260232
81regulation of glucocorticoid secretion (GO:2000849)2.92030896
82regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92013028
83regulation of norepinephrine secretion (GO:0014061)2.91226542
84dendritic spine organization (GO:0097061)2.90804617
85neuromuscular process controlling posture (GO:0050884)2.90152605
86ATP hydrolysis coupled proton transport (GO:0015991)2.89666203
87energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.89666203
88membrane hyperpolarization (GO:0060081)2.89284105
89intra-S DNA damage checkpoint (GO:0031573)2.88024728
90synapse assembly (GO:0007416)2.85515583
91DNA methylation involved in gamete generation (GO:0043046)2.85501727
92regulation of respiratory gaseous exchange (GO:0043576)2.84963257
93positive regulation of potassium ion transmembrane transport (GO:1901381)2.84920782
94positive regulation of action potential (GO:0045760)2.84003120
95regulation of vesicle fusion (GO:0031338)2.83815909
96nephron epithelium morphogenesis (GO:0072088)2.82360980
97nephron tubule morphogenesis (GO:0072078)2.82360980
98nephron tubule development (GO:0072080)2.82236870
99neurotransmitter transport (GO:0006836)2.81952620
100long-term synaptic potentiation (GO:0060291)2.81663273
101positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.80477904
102presynaptic membrane organization (GO:0097090)2.80254609
103cerebellar Purkinje cell differentiation (GO:0021702)2.80209479
104negative regulation of catecholamine secretion (GO:0033604)2.78188211
105regulation of synapse assembly (GO:0051963)2.77378807
106detection of calcium ion (GO:0005513)2.76695476
107learning (GO:0007612)2.75919681
108positive regulation of dendritic spine morphogenesis (GO:0061003)2.75631076
109phenylpropanoid metabolic process (GO:0009698)2.74980902
110cellular potassium ion homeostasis (GO:0030007)2.73425148
111cell communication involved in cardiac conduction (GO:0086065)2.73387555
112hippocampus development (GO:0021766)2.73079360
113synaptic vesicle docking involved in exocytosis (GO:0016081)2.72716564
114anatomical structure regression (GO:0060033)2.71616252
115response to cocaine (GO:0042220)2.70483366
116gamma-aminobutyric acid transport (GO:0015812)2.69841695
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69446492
118regulation of synaptic transmission, glutamatergic (GO:0051966)2.69238985
119regulation of cell communication by electrical coupling (GO:0010649)2.69074135
120regulation of postsynaptic membrane potential (GO:0060078)2.68983960
121cellular response to ammonium ion (GO:0071242)2.68917593
122cochlea development (GO:0090102)2.68562014
123regulation of excitatory postsynaptic membrane potential (GO:0060079)2.68536024
124innervation (GO:0060384)2.68372567
125regulation of NFAT protein import into nucleus (GO:0051532)2.68338285
126central nervous system projection neuron axonogenesis (GO:0021952)2.67936840
127establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67431173
128mitochondrion transport along microtubule (GO:0047497)2.67431173
129protein localization to cilium (GO:0061512)2.65215067
130lens fiber cell development (GO:0070307)2.64850536
131lung-associated mesenchyme development (GO:0060484)2.64297119
132membrane depolarization during action potential (GO:0086010)2.63837427
133membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.56977252
134response to auditory stimulus (GO:0010996)2.56349998
135neurotransmitter catabolic process (GO:0042135)2.54601164
136spinal cord development (GO:0021510)2.53981789
137phosphorelay signal transduction system (GO:0000160)2.53543310
138regulation of heart rate by cardiac conduction (GO:0086091)2.49356158
139telencephalon development (GO:0021537)2.48607911
140positive regulation of gastrulation (GO:2000543)2.48578973
141ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.46937978
142regulation of non-canonical Wnt signaling pathway (GO:2000050)2.45950476
143action potential (GO:0001508)2.45498122
144neuromuscular synaptic transmission (GO:0007274)2.45098444
145potassium ion import (GO:0010107)2.44370769
146renal tubule development (GO:0061326)2.44171175
147nonmotile primary cilium assembly (GO:0035058)2.43239145
148adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.42990436
149cerebellar granule cell differentiation (GO:0021707)2.42411955
150regulation of calcium ion-dependent exocytosis (GO:0017158)2.40617730
151body morphogenesis (GO:0010171)2.39774033
152membrane repolarization during action potential (GO:0086011)2.39597198
153synaptic transmission, cholinergic (GO:0007271)2.38266554
154phenol-containing compound catabolic process (GO:0019336)2.37093817
155regulation of nuclear cell cycle DNA replication (GO:0033262)2.36699422
156neuronal action potential (GO:0019228)2.36080539
157regulation of neurotransmitter levels (GO:0001505)2.33639146
158substrate-independent telencephalic tangential migration (GO:0021826)2.33531604
159substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.33531604
160cardiac conduction (GO:0061337)2.33270838
161adult walking behavior (GO:0007628)2.31316208
162nephron epithelium development (GO:0072009)2.31177171
163regulation of dendritic spine morphogenesis (GO:0061001)2.30968328

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.25724771
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.45829282
3GBX2_23144817_ChIP-Seq_PC3_Human3.65034313
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.26354795
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18775944
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16774480
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13889419
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94509229
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.79764426
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73010574
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72760737
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72760737
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.72358283
14REST_21632747_ChIP-Seq_MESCs_Mouse2.70431946
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64474543
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61336650
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60800798
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49413566
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46550066
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.44137489
21TAF15_26573619_Chip-Seq_HEK293_Human2.41972181
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.41633814
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38281634
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18891643
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.18743536
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.16752809
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08171550
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.02522170
29ZNF274_21170338_ChIP-Seq_K562_Hela2.00649004
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95794446
31DROSHA_22980978_ChIP-Seq_HELA_Human1.93006318
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.82256110
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74061773
34AR_21572438_ChIP-Seq_LNCaP_Human1.73922276
35VDR_22108803_ChIP-Seq_LS180_Human1.71655261
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.69514526
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62160172
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61306981
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61260509
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58582914
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55825822
42P300_19829295_ChIP-Seq_ESCs_Human1.52942132
43CTCF_27219007_Chip-Seq_Bcells_Human1.52702661
44SMAD4_21799915_ChIP-Seq_A2780_Human1.52636307
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.48675927
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.47808114
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46844721
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46227092
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42994187
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41699195
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37567827
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36992537
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34426122
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34418618
55RNF2_27304074_Chip-Seq_NSC_Mouse1.33812962
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30154062
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30018094
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.29859793
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.28601168
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26170857
61IGF1R_20145208_ChIP-Seq_DFB_Human1.24129285
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22982670
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22518268
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22362713
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21867931
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21653345
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.17679192
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17633242
69AR_25329375_ChIP-Seq_VCAP_Human1.17219930
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16354071
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11850591
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10458412
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10458412
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09489570
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08271657
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06967434
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06666076
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06232301
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04283938
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03976074
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03758948
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03414268
83KDM2B_26808549_Chip-Seq_K562_Human1.03350462
84P68_20966046_ChIP-Seq_HELA_Human1.03326641
85FUS_26573619_Chip-Seq_HEK293_Human1.02671799
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01988341
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.01648703
88BCAT_22108803_ChIP-Seq_LS180_Human1.00925414
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.99125293
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98597733
91JUN_21703547_ChIP-Seq_K562_Human0.97616026
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97370080
93DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96944747
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.96767725
95AR_19668381_ChIP-Seq_PC3_Human0.96326127
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.96184965
97ER_23166858_ChIP-Seq_MCF-7_Human0.95875456
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95500889
99STAT3_23295773_ChIP-Seq_U87_Human0.94905467
100AHR_22903824_ChIP-Seq_MCF-7_Human0.94330414
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93345875
102STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93239979
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91975515
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91738332
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90933096
106MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90050745
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89896440
108RUNX2_22187159_ChIP-Seq_PCA_Human0.89841253
109CBP_20019798_ChIP-Seq_JUKART_Human0.89772801
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89772801
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89366472
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88478426
113E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88025053
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87773916
115NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87473721
116GATA1_26923725_Chip-Seq_HPCs_Mouse0.87435692
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.87395222
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87001143
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.86024706
120TCF4_23295773_ChIP-Seq_U87_Human0.85973800
121ERA_21632823_ChIP-Seq_H3396_Human0.85911923
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.82183571
123OCT4_19829295_ChIP-Seq_ESCs_Human0.81766853
124MYC_19829295_ChIP-Seq_ESCs_Human0.81210637
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80339006
126P53_21459846_ChIP-Seq_SAOS-2_Human0.80213318
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80167900
128PHF8_20622854_ChIP-Seq_HELA_Human0.80156832
129IRF1_19129219_ChIP-ChIP_H3396_Human0.80051136
130SOX3_22085726_ChIP-Seq_NPCs_Mouse0.78641607
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.77294846
132E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76948205
133SA1_27219007_Chip-Seq_Bcells_Human0.76468229
134LXR_22292898_ChIP-Seq_THP-1_Human0.76161203
135SMC4_20622854_ChIP-Seq_HELA_Human0.75237774
136ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74940457
137WDR5_24793694_ChIP-Seq_LNCAP_Human0.74805586
138NCOR_22424771_ChIP-Seq_293T_Human0.74356984
139RAC3_21632823_ChIP-Seq_H3396_Human0.74285167
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73403707
141CREB1_26743006_Chip-Seq_LNCaP_Human0.72729788
142KLF4_19829295_ChIP-Seq_ESCs_Human0.72488744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.47635837
2MP0003880_abnormal_central_pattern4.36712769
3MP0003635_abnormal_synaptic_transmissio3.47077090
4MP0004270_analgesia3.14569574
5MP0005423_abnormal_somatic_nervous3.02936326
6MP0006276_abnormal_autonomic_nervous3.01462470
7MP0001968_abnormal_touch/_nociception3.01101301
8MP0002735_abnormal_chemical_nociception2.94902846
9MP0002063_abnormal_learning/memory/cond2.83719904
10MP0009745_abnormal_behavioral_response2.75441708
11MP0006292_abnormal_olfactory_placode2.64991399
12MP0003122_maternal_imprinting2.62365902
13MP0002064_seizures2.55815076
14MP0009046_muscle_twitch2.52591859
15MP0002572_abnormal_emotion/affect_behav2.50291311
16MP0002734_abnormal_mechanical_nocicepti2.45071158
17MP0001440_abnormal_grooming_behavior2.35654296
18MP0002736_abnormal_nociception_after2.33221955
19MP0000778_abnormal_nervous_system2.32150911
20MP0002272_abnormal_nervous_system2.29194478
21MP0000751_myopathy2.19792900
22MP0002184_abnormal_innervation2.18812863
23MP0010030_abnormal_orbit_morphology2.18682725
24MP0001486_abnormal_startle_reflex2.18093461
25MP0002837_dystrophic_cardiac_calcinosis2.17884653
26MP0001529_abnormal_vocalization2.08300999
27MP0002733_abnormal_thermal_nociception2.07406681
28MP0001984_abnormal_olfaction2.04616148
29MP0000566_synostosis2.03154644
30MP0002067_abnormal_sensory_capabilities1.89416882
31MP0005645_abnormal_hypothalamus_physiol1.88532476
32MP0001970_abnormal_pain_threshold1.83543659
33MP0005386_behavior/neurological_phenoty1.82004938
34MP0004924_abnormal_behavior1.82004938
35MP0003136_yellow_coat_color1.77809472
36MP0004858_abnormal_nervous_system1.74965543
37MP0003283_abnormal_digestive_organ1.74556168
38MP0009780_abnormal_chondrocyte_physiolo1.74072970
39MP0002557_abnormal_social/conspecific_i1.70878400
40MP0003329_amyloid_beta_deposits1.70447889
41MP0001501_abnormal_sleep_pattern1.68873094
42MP0004147_increased_porphyrin_level1.56289048
43MP0008877_abnormal_DNA_methylation1.53935587
44MP0002822_catalepsy1.53391471
45MP0004811_abnormal_neuron_physiology1.52674111
46MP0002909_abnormal_adrenal_gland1.49118455
47MP0004142_abnormal_muscle_tone1.45083940
48MP0002938_white_spotting1.43057837
49MP0004133_heterotaxia1.42152748
50MP0002882_abnormal_neuron_morphology1.41011374
51MP0000049_abnormal_middle_ear1.40461092
52MP0008995_early_reproductive_senescence1.39127662
53MP0000678_abnormal_parathyroid_gland1.38411511
54MP0000955_abnormal_spinal_cord1.38385957
55MP0002163_abnormal_gland_morphology1.38168510
56MP0003646_muscle_fatigue1.34153457
57MP0005499_abnormal_olfactory_system1.32626709
58MP0005394_taste/olfaction_phenotype1.32626709
59MP0008875_abnormal_xenobiotic_pharmacok1.29545168
60MP0002066_abnormal_motor_capabilities/c1.28960910
61MP0004233_abnormal_muscle_weight1.27119044
62MP0004215_abnormal_myocardial_fiber1.26519250
63MP0003879_abnormal_hair_cell1.26189098
64MP0003183_abnormal_peptide_metabolism1.25765318
65MP0001502_abnormal_circadian_rhythm1.24518992
66MP0005646_abnormal_pituitary_gland1.24391117
67MP0003195_calcinosis1.22874998
68MP0003137_abnormal_impulse_conducting1.22613839
69MP0004085_abnormal_heartbeat1.21668044
70MP0002653_abnormal_ependyma_morphology1.19395569
71MP0003938_abnormal_ear_development1.18692839
72MP0008569_lethality_at_weaning1.18563652
73MP0004484_altered_response_of1.18225985
74MP0003121_genomic_imprinting1.17922767
75MP0004742_abnormal_vestibular_system1.13436971
76MP0004885_abnormal_endolymph1.10195176
77MP0002152_abnormal_brain_morphology1.08972402
78MP0001485_abnormal_pinna_reflex1.08914811
79MP0001346_abnormal_lacrimal_gland1.08518451
80MP0004019_abnormal_vitamin_homeostasis1.07570349
81MP0001188_hyperpigmentation1.02873706
82MP0008789_abnormal_olfactory_epithelium1.02082400
83MP0008961_abnormal_basal_metabolism0.99442836
84MP0000631_abnormal_neuroendocrine_gland0.97605789
85MP0002752_abnormal_somatic_nervous0.97546813
86MP0003890_abnormal_embryonic-extraembry0.96143146
87MP0002249_abnormal_larynx_morphology0.92029455
88MP0003123_paternal_imprinting0.91602398
89MP0005083_abnormal_biliary_tract0.91482083
90MP0005365_abnormal_bile_salt0.91452625
91MP0005670_abnormal_white_adipose0.91385787
92MP0001905_abnormal_dopamine_level0.91253606
93MP0005551_abnormal_eye_electrophysiolog0.90302237
94MP0005195_abnormal_posterior_eye0.89897658
95MP0009379_abnormal_foot_pigmentation0.86700275
96MP0010329_abnormal_lipoprotein_level0.85720864
97MP0004036_abnormal_muscle_relaxation0.84589883
98MP0002876_abnormal_thyroid_physiology0.83284080
99MP0009384_cardiac_valve_regurgitation0.83199848
100MP0002229_neurodegeneration0.82820678
101MP0008775_abnormal_heart_ventricle0.81982680
102MP0001963_abnormal_hearing_physiology0.81200745
103MP0001944_abnormal_pancreas_morphology0.80918647
104MP0002069_abnormal_eating/drinking_beha0.80351919
105MP0004084_abnormal_cardiac_muscle0.79764337
106MP0003119_abnormal_digestive_system0.79445409
107MP0001299_abnormal_eye_distance/0.78555040
108MP0003878_abnormal_ear_physiology0.76807895
109MP0005377_hearing/vestibular/ear_phenot0.76807895
110MP0005379_endocrine/exocrine_gland_phen0.75904928
111MP0000013_abnormal_adipose_tissue0.74645403
112MP0002972_abnormal_cardiac_muscle0.74613588
113MP0003787_abnormal_imprinting0.74494457
114MP0000604_amyloidosis0.74459488
115MP0002751_abnormal_autonomic_nervous0.73584934
116MP0006035_abnormal_mitochondrial_morpho0.73360348
117MP0000026_abnormal_inner_ear0.73341218
118MP0004145_abnormal_muscle_electrophysio0.72393246
119MP0002102_abnormal_ear_morphology0.72273855
120MP0003861_abnormal_nervous_system0.72155528
121MP0001727_abnormal_embryo_implantation0.71016282
122MP0005620_abnormal_muscle_contractility0.70819601
123MP0003633_abnormal_nervous_system0.70663867
124MP0001986_abnormal_taste_sensitivity0.69474927
125MP0002638_abnormal_pupillary_reflex0.68758294
126MP0008872_abnormal_physiological_respon0.67639920
127MP0003634_abnormal_glial_cell0.67631538
128MP0005623_abnormal_meninges_morphology0.66558843
129MP0004130_abnormal_muscle_cell0.66532354
130MP0003631_nervous_system_phenotype0.62518315
131MP0002106_abnormal_muscle_physiology0.61645682

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.96753049
2Myokymia (HP:0002411)5.22656136
3Focal seizures (HP:0007359)4.67183811
4Atonic seizures (HP:0010819)4.28716734
5Epileptic encephalopathy (HP:0200134)4.20664801
6Nephronophthisis (HP:0000090)4.08186935
7Visual hallucinations (HP:0002367)4.06130126
8Acute necrotizing encephalopathy (HP:0006965)3.94982800
9Polyphagia (HP:0002591)3.93494439
10Absence seizures (HP:0002121)3.75240775
11True hermaphroditism (HP:0010459)3.71927474
12Abnormal mitochondria in muscle tissue (HP:0008316)3.71132473
13Pancreatic fibrosis (HP:0100732)3.70641248
14Polydipsia (HP:0001959)3.68721659
15Abnormal drinking behavior (HP:0030082)3.68721659
16Febrile seizures (HP:0002373)3.61519292
17Severe visual impairment (HP:0001141)3.58846604
18Abnormality of the aortic arch (HP:0012303)3.57206487
19Failure to thrive in infancy (HP:0001531)3.48679472
20Progressive macrocephaly (HP:0004481)3.44662722
21Pheochromocytoma (HP:0002666)3.44157221
22Dialeptic seizures (HP:0011146)3.31353511
23Neuroendocrine neoplasm (HP:0100634)3.22644107
24Abnormality of the renal medulla (HP:0100957)3.22031173
25Progressive cerebellar ataxia (HP:0002073)3.13319798
26Progressive inability to walk (HP:0002505)3.06483241
27Type II lissencephaly (HP:0007260)3.04832833
28Generalized tonic-clonic seizures (HP:0002069)3.04085759
29Tubular atrophy (HP:0000092)2.95210345
30Limb dystonia (HP:0002451)2.95067498
31Polyuria (HP:0000103)2.95029363
32Abnormal eating behavior (HP:0100738)2.91962521
33Broad-based gait (HP:0002136)2.91741650
34Amblyopia (HP:0000646)2.89139614
35Acute encephalopathy (HP:0006846)2.88280986
36Pancreatic cysts (HP:0001737)2.88238018
37Abnormal urine output (HP:0012590)2.83775915
38Cystic liver disease (HP:0006706)2.78104687
39Mitochondrial inheritance (HP:0001427)2.77510524
40Mutism (HP:0002300)2.77379993
41Abnormality of the labia minora (HP:0012880)2.76007851
42Abnormality of renal excretion (HP:0011036)2.71325444
43Abnormality of glycolysis (HP:0004366)2.70820454
44Increased serum pyruvate (HP:0003542)2.70820454
45Sclerocornea (HP:0000647)2.67462527
46Sudden death (HP:0001699)2.66662503
47Truncus arteriosus (HP:0001660)2.64459992
48Abnormality of the renal cortex (HP:0011035)2.63670076
49Hyperventilation (HP:0002883)2.61173389
50Molar tooth sign on MRI (HP:0002419)2.56684332
51Abnormality of midbrain morphology (HP:0002418)2.56684332
52Decreased circulating renin level (HP:0003351)2.56626001
53Supranuclear gaze palsy (HP:0000605)2.47927278
54Abnormality of the corticospinal tract (HP:0002492)2.46072346
55Termporal pattern (HP:0011008)2.44299255
56Insidious onset (HP:0003587)2.44299255
57Aplasia/Hypoplasia of the brainstem (HP:0007362)2.42902976
58Hypoplasia of the brainstem (HP:0002365)2.42902976
59Excessive salivation (HP:0003781)2.40729251
60Drooling (HP:0002307)2.40729251
61Oligomenorrhea (HP:0000876)2.40435030
62Urinary urgency (HP:0000012)2.40316400
63Ankle clonus (HP:0011448)2.39684471
64Congenital hepatic fibrosis (HP:0002612)2.38963334
65Cerebellar dysplasia (HP:0007033)2.38909767
66Epileptiform EEG discharges (HP:0011182)2.38632019
67EEG with generalized epileptiform discharges (HP:0011198)2.38099727
68Tubulointerstitial fibrosis (HP:0005576)2.34395771
69Specific learning disability (HP:0001328)2.33662526
70Poor suck (HP:0002033)2.31341448
71Optic disc pallor (HP:0000543)2.31084647
72Medial flaring of the eyebrow (HP:0010747)2.30611272
73Increased CSF lactate (HP:0002490)2.28668276
74Truncal ataxia (HP:0002078)2.28352085
75Hypsarrhythmia (HP:0002521)2.26413599
76Growth hormone deficiency (HP:0000824)2.26187798
77Abnormal hair whorl (HP:0010721)2.24139994
78Urinary bladder sphincter dysfunction (HP:0002839)2.21911313
79Neoplasm of the peripheral nervous system (HP:0100007)2.21377459
80Stage 5 chronic kidney disease (HP:0003774)2.21148689
81Neurofibrillary tangles (HP:0002185)2.20949430
82Cerebral inclusion bodies (HP:0100314)2.20233377
83Anencephaly (HP:0002323)2.20226802
84Anxiety (HP:0000739)2.19849753
85Male pseudohermaphroditism (HP:0000037)2.17027243
86Gait imbalance (HP:0002141)2.14183884
87Poor eye contact (HP:0000817)2.13085424
88Occipital encephalocele (HP:0002085)2.11325875
89Fetal akinesia sequence (HP:0001989)2.11197933
90Poor coordination (HP:0002370)2.10881916
91Syncope (HP:0001279)2.10190961
92Severe muscular hypotonia (HP:0006829)2.08758570
93Esotropia (HP:0000565)2.08594475
94Action tremor (HP:0002345)2.08431775
95Hypoventilation (HP:0002791)2.07889502
96Sleep apnea (HP:0010535)2.05365142
97Leukodystrophy (HP:0002415)2.04912981
98Abnormal social behavior (HP:0012433)2.04395591
99Impaired social interactions (HP:0000735)2.04395591
100Depression (HP:0000716)2.04027719
101Agitation (HP:0000713)2.04019925
102Rib fusion (HP:0000902)2.02292828
103Calf muscle hypertrophy (HP:0008981)2.01872673
104Confusion (HP:0001289)2.01644060
105Status epilepticus (HP:0002133)2.01320809
106Chronic hepatic failure (HP:0100626)2.00055091
107Inability to walk (HP:0002540)1.99667719
108Generalized hypotonia (HP:0001290)1.99538176
109Impaired vibration sensation in the lower limbs (HP:0002166)1.99337843
110Shawl scrotum (HP:0000049)1.97917747
111Cerebral edema (HP:0002181)1.96955314
112Hyperthyroidism (HP:0000836)1.96357105
113Amyotrophic lateral sclerosis (HP:0007354)1.95974116
114Hemiparesis (HP:0001269)1.95718064
115Concave nail (HP:0001598)1.95492319
116Tachypnea (HP:0002789)1.95310826
117Spastic gait (HP:0002064)1.95153344
118Muscle hypertrophy of the lower extremities (HP:0008968)1.95099292
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.93475454
120Anophthalmia (HP:0000528)1.93173557
121Torticollis (HP:0000473)1.92449318
122Postaxial foot polydactyly (HP:0001830)1.91187117
123Abnormality of pain sensation (HP:0010832)1.91090687
124Impaired pain sensation (HP:0007328)1.91090687
125Broad alveolar ridges (HP:0000187)1.90083016
126Lissencephaly (HP:0001339)1.89826303
127Maternal diabetes (HP:0009800)1.88507526
128Abnormal rod and cone electroretinograms (HP:0008323)1.87206885
129Dysdiadochokinesis (HP:0002075)1.86141849
130Congenital primary aphakia (HP:0007707)1.85904544
131Progressive external ophthalmoplegia (HP:0000590)1.84132018
132Prolonged QT interval (HP:0001657)1.83869840
133Severe Myopia (HP:0011003)1.83499389
134Primary atrial arrhythmia (HP:0001692)1.83065290
135Abnormality of the calf musculature (HP:0001430)1.82072434
136Morphological abnormality of the pyramidal tract (HP:0002062)1.81975797
137Abnormal EKG (HP:0003115)1.81334801
138Narrow nasal bridge (HP:0000446)1.81308933
139Hyperphosphatemia (HP:0002905)1.81124859
140Ventricular fibrillation (HP:0001663)1.80127479
141Oligodactyly (hands) (HP:0001180)1.80054753
142Nephrogenic diabetes insipidus (HP:0009806)1.78820374
143Impulsivity (HP:0100710)1.78670901
144Akinesia (HP:0002304)1.78306403
145X-linked dominant inheritance (HP:0001423)1.78028474
146Abnormality of the vitreous humor (HP:0004327)1.77930308
147Genetic anticipation (HP:0003743)1.77738063
148Hyperglycinuria (HP:0003108)1.77169559
149Myotonia (HP:0002486)1.76788646
150Exercise-induced myalgia (HP:0003738)1.76599258
151Sporadic (HP:0003745)1.76329561
152Supraventricular tachycardia (HP:0004755)1.76156167
153Decreased central vision (HP:0007663)1.74787009
154Spastic tetraplegia (HP:0002510)1.72137093
155Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72127163
156Furrowed tongue (HP:0000221)1.71429875
157Retinal dysplasia (HP:0007973)1.68540952
158Enlarged penis (HP:0000040)1.68041571
159Abnormality of the nasal septum (HP:0000419)1.66931921
160Left ventricular hypertrophy (HP:0001712)1.66100059
161Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66069524
162Tubulointerstitial abnormality (HP:0001969)1.63812255
163Optic nerve hypoplasia (HP:0000609)1.61208478
164Potter facies (HP:0002009)1.60549027
165Facial shape deformation (HP:0011334)1.60549027
166Abnormality of renin-angiotensin system (HP:0000847)1.60439540
167Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59996742
168Absent epiphyses (HP:0010577)1.59996742
169Hypercalciuria (HP:0002150)1.55763876
170Optic nerve coloboma (HP:0000588)1.55175918
171Septo-optic dysplasia (HP:0100842)1.54329791
172Polycystic kidney dysplasia (HP:0000113)1.53795990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.33752684
2NTRK33.59901030
3WNK43.19364941
4MAP3K122.96667513
5MAP3K92.92806490
6MINK12.85401157
7PINK12.75010491
8MAP3K42.72302329
9NTRK22.43169616
10PASK2.42738639
11CASK2.41796016
12MAP2K72.31086085
13MAPK152.29517514
14PHKG12.28063094
15PHKG22.28063094
16MAPK132.20992806
17CAMKK12.11038019
18KSR11.95852885
19MAP2K41.91433300
20EPHA41.79050764
21NME11.73053990
22ZAK1.69921781
23PAK61.69199183
24FRK1.65903027
25PLK21.61783965
26SIK31.55411025
27UHMK11.53861908
28DAPK21.50567980
29SIK21.39458651
30LATS21.38879365
31PNCK1.38443814
32GRK51.28817904
33CDK51.24244593
34RIPK11.22949408
35DYRK31.22345130
36NTRK11.19149178
37DYRK21.18030685
38STK391.17752133
39GRK71.17153468
40EPHB21.16437513
41TIE11.15759019
42GRK11.13322817
43DAPK11.11443097
44BCR1.10144820
45PAK31.09777002
46CAMK2A1.06271194
47LIMK11.05685960
48PKN21.04463128
49PRKCG1.03172495
50CAMK2D1.01076342
51BRSK11.00710765
52ARAF0.99983448
53KSR20.99661640
54TLK10.96862346
55PRKD30.92875197
56PDK30.92197615
57PDK40.92197615
58ERBB30.90845632
59WNK10.89397587
60CDK190.89318742
61TAOK10.88951130
62MAPK120.88809416
63CDK140.88648216
64MARK20.86663263
65MAPKAPK50.86661078
66ERBB20.86603727
67FES0.85991132
68CAMK2B0.84763263
69TYRO30.84705117
70CDK180.82430552
71DYRK1B0.79529870
72DYRK1A0.78753194
73SIK10.77681692
74CSNK1G20.76456910
75PRKCE0.74626755
76MYLK0.74597999
77TAOK30.74372028
78STK30.73109634
79CDK150.72668246
80PRKCI0.72230720
81MUSK0.72186257
82WNK30.71618556
83PKN10.70967017
84MAP2K60.70870729
85ADRBK20.69715876
86RPS6KA20.67730406
87SGK2230.66679082
88SGK4940.66679082
89CSNK1A10.66019616
90NEK20.65288324
91CSNK1E0.65251662
92LMTK20.63679994
93PRKCZ0.61559435
94STK110.61468842
95RIPK40.61231627
96TSSK60.61020438
97ROCK20.60968023
98TNIK0.59370994
99CDK11A0.59045665
100MAP4K20.58813458
101ADRBK10.58278566
102RET0.57953500
103MAP3K20.57794049
104EEF2K0.57535719
105CSNK1A1L0.56825025
106STK240.56538553
107NEK10.56414010
108PIK3CA0.56056865
109BMX0.55779328
110PRKAA10.54807760
111BCKDK0.54599914
112PTK60.52651122
113CCNB10.52157753
114PRKG10.51620424
115FER0.51606657
116MAPKAPK30.51514625
117PTK2B0.51321986
118CAMK40.51130479
119CAMK2G0.50028187
120OXSR10.49508469
121SGK20.49212295
122PRKCQ0.48951147
123WEE10.48572492
124CAMK10.48286674
125CSNK1G30.47833461
126RPS6KA30.47299601
127BMPR1B0.47180466
128CAMK1G0.46187015
129BMPR20.45459897
130MAP3K70.45246526
131CAMKK20.44459298
132CDK80.44398677
133PRKCA0.43775297
134PRKACA0.43044102
135MAP2K10.41943132
136ROCK10.41338747
137DAPK30.41289325
138SGK10.41008091
139ERBB40.40908506
140PRKAA20.40899623
141INSRR0.40523236
142PRKG20.39213887
143PRKDC0.39054153
144FYN0.38725003
145CSNK2A20.38522631
146PRKCH0.37986528
147MAPK90.36170929
148PRKCB0.36163750
149PRKACB0.35610562
150PDK20.35572138

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.76411946
2Oxidative phosphorylation_Homo sapiens_hsa001903.16247550
3Synaptic vesicle cycle_Homo sapiens_hsa047213.12449297
4Sulfur relay system_Homo sapiens_hsa041223.05373731
5Parkinsons disease_Homo sapiens_hsa050122.68749729
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.57307231
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49398342
8GABAergic synapse_Homo sapiens_hsa047272.44255322
9Cardiac muscle contraction_Homo sapiens_hsa042602.42914726
10Alzheimers disease_Homo sapiens_hsa050102.30486080
11Collecting duct acid secretion_Homo sapiens_hsa049662.23533198
12Olfactory transduction_Homo sapiens_hsa047402.19854759
13Circadian entrainment_Homo sapiens_hsa047132.15619299
14Morphine addiction_Homo sapiens_hsa050322.11179228
15Glutamatergic synapse_Homo sapiens_hsa047242.10686458
16Cyanoamino acid metabolism_Homo sapiens_hsa004602.06112124
17Long-term potentiation_Homo sapiens_hsa047201.96127950
18Dopaminergic synapse_Homo sapiens_hsa047281.92149765
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86420420
20Huntingtons disease_Homo sapiens_hsa050161.83885903
21Taste transduction_Homo sapiens_hsa047421.80507332
22Serotonergic synapse_Homo sapiens_hsa047261.73882038
23Long-term depression_Homo sapiens_hsa047301.73416108
24Cholinergic synapse_Homo sapiens_hsa047251.69454183
25Fat digestion and absorption_Homo sapiens_hsa049751.68677469
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68153695
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67369839
28Vibrio cholerae infection_Homo sapiens_hsa051101.65802451
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65702942
30Insulin secretion_Homo sapiens_hsa049111.63985949
31Amphetamine addiction_Homo sapiens_hsa050311.63902339
32Salivary secretion_Homo sapiens_hsa049701.63025733
33Renin secretion_Homo sapiens_hsa049241.59960408
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59179635
35Gastric acid secretion_Homo sapiens_hsa049711.50791969
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50569738
37Linoleic acid metabolism_Homo sapiens_hsa005911.48910649
38Oxytocin signaling pathway_Homo sapiens_hsa049211.41874271
39Axon guidance_Homo sapiens_hsa043601.41312939
40Gap junction_Homo sapiens_hsa045401.39738925
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36205210
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34356803
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33260618
44Calcium signaling pathway_Homo sapiens_hsa040201.32205667
45Steroid biosynthesis_Homo sapiens_hsa001001.31512303
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29653855
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25585476
48GnRH signaling pathway_Homo sapiens_hsa049121.21163642
49Arginine and proline metabolism_Homo sapiens_hsa003301.20215782
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17249923
51Vitamin digestion and absorption_Homo sapiens_hsa049771.16423966
52Dilated cardiomyopathy_Homo sapiens_hsa054141.15976758
53Cocaine addiction_Homo sapiens_hsa050301.13489426
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11242064
55Phenylalanine metabolism_Homo sapiens_hsa003601.07354975
56Basal cell carcinoma_Homo sapiens_hsa052171.05950550
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05651172
58Glycerolipid metabolism_Homo sapiens_hsa005611.04034356
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02644586
60Ribosome_Homo sapiens_hsa030101.01923668
61ABC transporters_Homo sapiens_hsa020100.99357836
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98315149
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97608851
64Chemical carcinogenesis_Homo sapiens_hsa052040.96777940
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.94927171
66Notch signaling pathway_Homo sapiens_hsa043300.94554861
67Histidine metabolism_Homo sapiens_hsa003400.93704662
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93503721
69Melanogenesis_Homo sapiens_hsa049160.93189313
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92211500
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88861884
72Estrogen signaling pathway_Homo sapiens_hsa049150.88453127
73cAMP signaling pathway_Homo sapiens_hsa040240.86689416
74Tryptophan metabolism_Homo sapiens_hsa003800.86192878
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85026981
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84924267
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84734657
78Ether lipid metabolism_Homo sapiens_hsa005650.84127249
79Butanoate metabolism_Homo sapiens_hsa006500.80478890
80Folate biosynthesis_Homo sapiens_hsa007900.80323932
81Selenocompound metabolism_Homo sapiens_hsa004500.79567875
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78944968
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78924061
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.78781670
85Fatty acid biosynthesis_Homo sapiens_hsa000610.78740549
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77971951
87Peroxisome_Homo sapiens_hsa041460.77473111
88ErbB signaling pathway_Homo sapiens_hsa040120.77257936
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77244497
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76322014
91Phototransduction_Homo sapiens_hsa047440.74485505
92Retinol metabolism_Homo sapiens_hsa008300.74073241
93Mineral absorption_Homo sapiens_hsa049780.73837095
94Type II diabetes mellitus_Homo sapiens_hsa049300.73668523
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73498242
96Oocyte meiosis_Homo sapiens_hsa041140.72324944
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69729435
98Tyrosine metabolism_Homo sapiens_hsa003500.69703892
99Dorso-ventral axis formation_Homo sapiens_hsa043200.69380912
100Starch and sucrose metabolism_Homo sapiens_hsa005000.66328741
101Glioma_Homo sapiens_hsa052140.65977336
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.64450045
103Glucagon signaling pathway_Homo sapiens_hsa049220.62878901
104Arginine biosynthesis_Homo sapiens_hsa002200.62746922
105Fatty acid degradation_Homo sapiens_hsa000710.61581870
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61522050
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60269683
108Regulation of autophagy_Homo sapiens_hsa041400.59637655
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57565883
110Protein digestion and absorption_Homo sapiens_hsa049740.57533693
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57282340
112Renal cell carcinoma_Homo sapiens_hsa052110.55636386
113Alcoholism_Homo sapiens_hsa050340.55507636
114Pancreatic secretion_Homo sapiens_hsa049720.55396332
115MAPK signaling pathway_Homo sapiens_hsa040100.53419754
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53325099
117Thyroid hormone synthesis_Homo sapiens_hsa049180.51527822
118Fatty acid metabolism_Homo sapiens_hsa012120.51241535
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49965176
120Metabolic pathways_Homo sapiens_hsa011000.49524762
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48834345
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47560235
123Pyruvate metabolism_Homo sapiens_hsa006200.47399751
124Hedgehog signaling pathway_Homo sapiens_hsa043400.46241900
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45643621
126Prion diseases_Homo sapiens_hsa050200.43883433
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43322401
128VEGF signaling pathway_Homo sapiens_hsa043700.42865563
129Ras signaling pathway_Homo sapiens_hsa040140.42226562
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41428283
131Phagosome_Homo sapiens_hsa041450.40582951
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.38977448
133Insulin signaling pathway_Homo sapiens_hsa049100.38319211
134Ovarian steroidogenesis_Homo sapiens_hsa049130.37124313
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.37102872
136Colorectal cancer_Homo sapiens_hsa052100.35630643
137Rheumatoid arthritis_Homo sapiens_hsa053230.35564041
138Endometrial cancer_Homo sapiens_hsa052130.35488690
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34816981
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32480196
141Choline metabolism in cancer_Homo sapiens_hsa052310.32275818
142Rap1 signaling pathway_Homo sapiens_hsa040150.30237495
143Wnt signaling pathway_Homo sapiens_hsa043100.29087536
144Bile secretion_Homo sapiens_hsa049760.26802301
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24059716
146Type I diabetes mellitus_Homo sapiens_hsa049400.23328969
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22597549

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