TMEM79

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)8.57226347
2polyketide metabolic process (GO:0030638)8.57226347
3doxorubicin metabolic process (GO:0044598)8.57226347
4desmosome organization (GO:0002934)7.65204878
5keratinocyte differentiation (GO:0030216)7.02499191
6keratinocyte proliferation (GO:0043616)6.15627824
7negative regulation of epidermis development (GO:0045683)6.07400332
8regulation of mammary gland epithelial cell proliferation (GO:0033599)5.77650792
9* multicellular organismal water homeostasis (GO:0050891)5.72523475
10peptide cross-linking (GO:0018149)5.70577724
11negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.69787915
12epidermal cell differentiation (GO:0009913)5.56083268
13intestinal epithelial cell development (GO:0060576)5.49754176
14bundle of His cell to Purkinje myocyte communication (GO:0086069)5.47524285
15epidermis development (GO:0008544)5.45236211
16aminoglycoside antibiotic metabolic process (GO:0030647)5.41311835
17rRNA transcription (GO:0009303)5.18569144
18muscle organ morphogenesis (GO:0048644)5.17860674
19negative regulation of cell cycle G2/M phase transition (GO:1902750)5.13469940
20maintenance of protein location in nucleus (GO:0051457)5.03863069
21regulation of response to osmotic stress (GO:0047484)4.96723484
22arachidonic acid secretion (GO:0050482)4.94022645
23icosanoid secretion (GO:0032309)4.94022645
24* water homeostasis (GO:0030104)4.92291848
25somite rostral/caudal axis specification (GO:0032525)4.92185204
26cytidine catabolic process (GO:0006216)4.74138682
27cytidine deamination (GO:0009972)4.74138682
28cytidine metabolic process (GO:0046087)4.74138682
29interferon-gamma secretion (GO:0072643)4.66046813
30negative regulation of epidermal cell differentiation (GO:0045605)4.61368121
31detection of temperature stimulus (GO:0016048)4.57261621
32protein localization to kinetochore (GO:0034501)4.55921944
33notochord development (GO:0030903)4.53886409
34positive regulation of epidermal cell differentiation (GO:0045606)4.52382366
35lipoxygenase pathway (GO:0019372)4.50595127
36keratinocyte development (GO:0003334)4.42581557
37* establishment of skin barrier (GO:0061436)4.38685157
38negative regulation of telomerase activity (GO:0051974)4.34958212
39* regulation of water loss via skin (GO:0033561)4.29007664
40GDP-mannose metabolic process (GO:0019673)4.26821935
41hormone catabolic process (GO:0042447)4.20959466
42regulation of apoptotic process involved in morphogenesis (GO:1902337)4.17432159
43positive regulation of keratinocyte differentiation (GO:0045618)4.16998223
44negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.12105322
45regulation of nuclear cell cycle DNA replication (GO:0033262)4.11751738
46detection of bacterium (GO:0016045)4.11543215
47regulation of telomere maintenance via telomerase (GO:0032210)4.10942437
48response to water (GO:0009415)4.06344495
49ribosomal small subunit biogenesis (GO:0042274)4.04170777
50rRNA modification (GO:0000154)3.94658819
51icosanoid transport (GO:0071715)3.93338110
52fatty acid derivative transport (GO:1901571)3.93338110
53keratinization (GO:0031424)3.90170821
54negative regulation of interleukin-2 production (GO:0032703)3.88257320
55regulation of translation in response to stress (GO:0043555)3.87554256
56histone H4-K12 acetylation (GO:0043983)3.86305780
57regulation of MHC class I biosynthetic process (GO:0045343)3.84564216
58regulation of cilium movement (GO:0003352)3.82795491
59rRNA methylation (GO:0031167)3.82768610
60histone H4-K8 acetylation (GO:0043982)3.82170731
61histone H4-K5 acetylation (GO:0043981)3.82170731
62* positive regulation of epidermis development (GO:0045684)3.80806968
63hemidesmosome assembly (GO:0031581)3.73307082
64detection of other organism (GO:0098543)3.71745153
65proline transport (GO:0015824)3.71097033
66branching involved in mammary gland duct morphogenesis (GO:0060444)3.70744101
67viral transcription (GO:0019083)3.67615508
68epithelial cell differentiation involved in prostate gland development (GO:0060742)3.67612945
69mitotic sister chromatid segregation (GO:0000070)3.61276657
70quinone metabolic process (GO:1901661)3.60425632
71cullin deneddylation (GO:0010388)3.57172958
72positive regulation of odontogenesis (GO:0042482)3.56234074
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.55978538
74nucleoside transmembrane transport (GO:1901642)3.55947176
75sphingoid metabolic process (GO:0046519)3.52054918
76trophectodermal cell differentiation (GO:0001829)3.51719952
77regulation of G0 to G1 transition (GO:0070316)3.50219602
78heterochromatin organization (GO:0070828)3.48743186
79protein polyglutamylation (GO:0018095)3.47733531
80primary alcohol catabolic process (GO:0034310)3.45221962
81translational termination (GO:0006415)3.45154796
82negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.42958979
83hair cycle (GO:0042633)3.40172448
84molting cycle (GO:0042303)3.40172448
85DNA replication checkpoint (GO:0000076)3.38872557
86pyrimidine ribonucleoside catabolic process (GO:0046133)3.38414207
87phenol-containing compound catabolic process (GO:0019336)3.37328122
88response to dietary excess (GO:0002021)3.35539967
89intermediate filament cytoskeleton organization (GO:0045104)3.35288703
90intermediate filament organization (GO:0045109)3.34833728
91coenzyme catabolic process (GO:0009109)3.34673853
92protein localization to chromosome, centromeric region (GO:0071459)3.28657278
93skin morphogenesis (GO:0043589)3.26781311
94positive regulation of DNA-dependent DNA replication (GO:2000105)3.26005192
95cyclooxygenase pathway (GO:0019371)3.25403177
96gap junction assembly (GO:0016264)3.24997698
97regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.24440251
98intermediate filament-based process (GO:0045103)3.24010317
99positive regulation of monocyte chemotaxis (GO:0090026)3.23728523
100formation of translation preinitiation complex (GO:0001731)3.19831683
101diol metabolic process (GO:0034311)3.19001638
102intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.18842138
103ribosome biogenesis (GO:0042254)3.16981838
104phosphatidylinositol acyl-chain remodeling (GO:0036149)3.16775494
105protein deneddylation (GO:0000338)3.16529179
106ectoderm development (GO:0007398)3.16137550
107calcium-mediated signaling using intracellular calcium source (GO:0035584)3.14285452
108regulation of telomerase activity (GO:0051972)3.12331857
109negative regulation of keratinocyte proliferation (GO:0010839)3.09546273
110SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08248887
111negative regulation of telomere maintenance (GO:0032205)3.08070527
112ribonucleoprotein complex biogenesis (GO:0022613)3.07852882
113DNA replication-dependent nucleosome assembly (GO:0006335)3.06931900
114DNA replication-dependent nucleosome organization (GO:0034723)3.06931900
115linoleic acid metabolic process (GO:0043651)3.06806310
116protein targeting to ER (GO:0045047)3.05278085
117negative regulation of interferon-gamma production (GO:0032689)3.04656305
118cell fate commitment involved in formation of primary germ layer (GO:0060795)3.03606245
119phosphatidylserine acyl-chain remodeling (GO:0036150)3.03252922
120cotranslational protein targeting to membrane (GO:0006613)3.03070474
121pseudouridine synthesis (GO:0001522)3.01185941
122fatty acid elongation (GO:0030497)2.99485384
123detection of temperature stimulus involved in sensory perception (GO:0050961)2.98951545
124detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.98951545
125transepithelial transport (GO:0070633)2.98609923
126negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.97832188
127biotin metabolic process (GO:0006768)2.96627615
128viral life cycle (GO:0019058)2.96339485
129negative regulation of dendrite morphogenesis (GO:0050774)2.95345277
130translational elongation (GO:0006414)2.95000136
131nuclear pore complex assembly (GO:0051292)2.90699832
132ATP synthesis coupled proton transport (GO:0015986)2.90675836
133energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90675836
134establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90406668
135retinoic acid receptor signaling pathway (GO:0048384)2.88977513
136protein localization to endoplasmic reticulum (GO:0070972)2.88680076
137positive regulation of cellular amide metabolic process (GO:0034250)2.80893555
138regulation of keratinocyte differentiation (GO:0045616)2.77252979
139phosphatidylcholine acyl-chain remodeling (GO:0036151)2.72293944
140oligosaccharide catabolic process (GO:0009313)2.71070066
141phosphatidylserine metabolic process (GO:0006658)2.67452892
142branching involved in labyrinthine layer morphogenesis (GO:0060670)2.66793477
143ribosomal large subunit biogenesis (GO:0042273)2.66556663
144neutrophil activation involved in immune response (GO:0002283)2.64752580
145phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.64573367
146ribosomal small subunit assembly (GO:0000028)2.63419514
147nucleotide salvage (GO:0043173)2.58373812
148viral protein processing (GO:0019082)2.58012538
149long-chain fatty acid biosynthetic process (GO:0042759)2.57613139
150nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56732748
151regulation of cell proliferation involved in kidney development (GO:1901722)2.55624038
152virion assembly (GO:0019068)2.55338001
153amyloid precursor protein catabolic process (GO:0042987)2.54011318
154* regulation of epidermis development (GO:0045682)2.53689210
155regulation of epidermal cell differentiation (GO:0045604)2.53368767
156translational initiation (GO:0006413)2.51722447
157pyrimidine-containing compound salvage (GO:0008655)2.50251283
158pyrimidine nucleoside salvage (GO:0043097)2.50251283
159positive regulation of hair cycle (GO:0042635)2.48539153
160positive regulation of hair follicle development (GO:0051798)2.48539153
161regulation of natural killer cell differentiation (GO:0032823)2.44713763
162response to peptidoglycan (GO:0032494)2.42975742
163cellular protein complex disassembly (GO:0043624)2.41606057
164positive regulation of Cdc42 GTPase activity (GO:0043089)2.40365012
165regulation of monocyte chemotaxis (GO:0090025)2.36304339
166surfactant homeostasis (GO:0043129)2.35878059
167phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.35160679
168cell-substrate junction assembly (GO:0007044)2.34159866
169amino sugar catabolic process (GO:0046348)2.33797445
170polarized epithelial cell differentiation (GO:0030859)2.33478384
171tumor necrosis factor-mediated signaling pathway (GO:0033209)2.32445989
172establishment of tissue polarity (GO:0007164)2.32100256
173establishment of planar polarity (GO:0001736)2.32100256
174epithelium development (GO:0060429)2.30777314
175G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.30311730
176mitotic nuclear envelope reassembly (GO:0007084)2.27926015
177nuclear envelope reassembly (GO:0031468)2.27926015
178regulation of Cdc42 GTPase activity (GO:0043088)2.27698666
179defense response to fungus (GO:0050832)2.25978369
180nucleoside salvage (GO:0043174)2.25445712
181termination of RNA polymerase III transcription (GO:0006386)2.24568059
182transcription elongation from RNA polymerase III promoter (GO:0006385)2.24568059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.94446590
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.63501767
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.63501767
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.63501767
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.53228056
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.43281793
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.07610739
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.84536229
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.77558280
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73562009
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.69981218
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.66091148
13E2F7_22180533_ChIP-Seq_HELA_Human2.54401021
14KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.48540583
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.30313931
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.25562604
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.23190839
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16334667
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.10878671
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.98987356
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.98657561
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93522539
23* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.91192792
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.86754379
25VDR_21846776_ChIP-Seq_THP-1_Human1.85085976
26* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83094295
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.82952492
28NANOG_18692474_ChIP-Seq_MEFs_Mouse1.79260036
29NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.78886060
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75608951
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69911397
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69911397
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.65283338
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63086469
35ZNF263_19887448_ChIP-Seq_K562_Human1.60602227
36NANOG_18692474_ChIP-Seq_MESCs_Mouse1.59048728
37* ESR2_21235772_ChIP-Seq_MCF-7_Human1.58760191
38* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58610134
39* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.54629575
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49771798
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49737966
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49578953
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48148145
44* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.46662435
45* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44582504
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41233324
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.40793433
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.39850395
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38491943
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37908738
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37626539
52SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37445091
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.36275662
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35132172
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34337439
56* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.33746673
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33150217
58OCT4_18692474_ChIP-Seq_MEFs_Mouse1.33146467
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32480146
60* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32082213
61BCL6_27268052_Chip-Seq_Bcells_Human1.30360514
62POU5F1_16518401_ChIP-PET_MESCs_Mouse1.27515099
63DCP1A_22483619_ChIP-Seq_HELA_Human1.25468950
64* ETS1_20019798_ChIP-Seq_JURKAT_Human1.25056832
65* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23602729
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23041322
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23006738
68* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22856476
69* XRN2_22483619_ChIP-Seq_HELA_Human1.21766682
70VDR_24763502_ChIP-Seq_THP-1_Human1.19747079
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18798082
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18218130
73SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17556427
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17493441
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17434562
76E2F1_20622854_ChIP-Seq_HELA_Human1.17433621
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17247836
78* YY1_22570637_ChIP-Seq_MALME-3M_Human1.16339641
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.16291594
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15126697
81BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15122173
82MAF_26560356_Chip-Seq_TH2_Human1.14575277
83* RACK7_27058665_Chip-Seq_MCF-7_Human1.14430486
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14165314
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13780398
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13657313
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12801673
88ATF3_27146783_Chip-Seq_COLON_Human1.12569286
89E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12153582
90KDM5A_27292631_Chip-Seq_BREAST_Human1.10905724
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.08822146
92CTCF_20526341_ChIP-Seq_ESCs_Human1.08375011
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.08360901
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08032585
95SMC4_20622854_ChIP-Seq_HELA_Human1.07743834
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.07664401
97ELF5_23300383_ChIP-Seq_T47D_Human1.07397292
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.06191540
99IRF8_22096565_ChIP-ChIP_GC-B_Human1.05483041
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05180891
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05037550
102TFEB_21752829_ChIP-Seq_HELA_Human1.04836483
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.04262645
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04262358
105GATA6_25053715_ChIP-Seq_YYC3_Human1.03940677
106UBF1/2_26484160_Chip-Seq_HMECs_Human1.03788571
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03720497
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03272967
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01523282
110NANOG_16518401_ChIP-PET_MESCs_Mouse1.01382799
111GATA3_24758297_ChIP-Seq_MCF-7_Human1.01313190
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00606307
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00219784
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99987247
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.99285038
116EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98649007
117TP53_22127205_ChIP-Seq_IMR90_Human0.98471036
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98244910
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98189056
120* CTCF_26484167_Chip-Seq_Bcells_Mouse0.97234973
121PHF8_20622854_ChIP-Seq_HELA_Human0.96190124
122* SA1_27219007_Chip-Seq_Bcells_Human0.95365979
123GABP_19822575_ChIP-Seq_HepG2_Human0.94410480
124FOXM1_23109430_ChIP-Seq_U2OS_Human0.94369673
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.94352440
126* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93557010
127MYC_22102868_ChIP-Seq_BL_Human0.93260745
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93245258
129CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92919886
130PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92617747
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.92113736
132BCOR_27268052_Chip-Seq_Bcells_Human0.91653252
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91459617
134RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91436631
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91299534
136* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90705927
137MAF_26560356_Chip-Seq_TH1_Human0.90318303
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88860325
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88168036
140ELF1_20517297_ChIP-Seq_JURKAT_Human0.87970358
141STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86981734
142* TP63_22573176_ChIP-Seq_HFKS_Human0.86251442
143NANOG_16153702_ChIP-ChIP_HESCs_Human0.84854311
144* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.84801482
145EST1_17652178_ChIP-ChIP_JURKAT_Human0.84617236
146KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82944914
147IRF1_19129219_ChIP-ChIP_H3396_Human0.82832635
148NOTCH1_21737748_ChIP-Seq_TLL_Human0.81782559
149RUNX1_27514584_Chip-Seq_MCF-7_Human0.81765485
150ELK3_25401928_ChIP-Seq_HUVEC_Human0.81279415
151JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.81233535
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80610219
153SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80029816
154GATA4_25053715_ChIP-Seq_YYC3_Human0.78980103
155POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.78366758
156KLF5_25053715_ChIP-Seq_YYC3_Human0.77947127
157P68_20966046_ChIP-Seq_HELA_Human0.77765790
158E2F1_17053090_ChIP-ChIP_MCF-7_Human0.77182096
159* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.75887062
160LXR_22292898_ChIP-Seq_THP-1_Human0.75654200
161ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74279975
162TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72548848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier4.74491527
2MP0010234_abnormal_vibrissa_follicle4.61170645
3MP0002254_reproductive_system_inflammat4.13210279
4MP0004858_abnormal_nervous_system3.99358860
5MP0004264_abnormal_extraembryonic_tissu3.74241230
6MP0003011_delayed_dark_adaptation3.36286546
7MP0005501_abnormal_skin_physiology2.90392567
8MP0004381_abnormal_hair_follicle2.78074599
9MP0010352_gastrointestinal_tract_polyps2.65747673
10MP0005075_abnormal_melanosome_morpholog2.53128418
11MP0003705_abnormal_hypodermis_morpholog2.51726092
12MP0004957_abnormal_blastocyst_morpholog2.36165695
13MP0005275_abnormal_skin_tensile2.34415795
14MP0001986_abnormal_taste_sensitivity2.27311389
15MP0002098_abnormal_vibrissa_morphology2.22818243
16MP0005394_taste/olfaction_phenotype2.21832298
17MP0005499_abnormal_olfactory_system2.21832298
18MP0003191_abnormal_cellular_cholesterol2.14728533
19MP0003941_abnormal_skin_development2.13547184
20MP0002735_abnormal_chemical_nociception2.12254900
21MP0000579_abnormal_nail_morphology2.10415140
22MP0003890_abnormal_embryonic-extraembry2.07143377
23MP0005451_abnormal_body_composition2.03914605
24MP0010678_abnormal_skin_adnexa2.02695302
25MP0001216_abnormal_epidermal_layer1.99400674
26MP0000762_abnormal_tongue_morphology1.98822823
27MP0010771_integument_phenotype1.98693013
28MP0001968_abnormal_touch/_nociception1.94081470
29MP0002736_abnormal_nociception_after1.91476732
30MP0003315_abnormal_perineum_morphology1.83139759
31MP0000647_abnormal_sebaceous_gland1.80617955
32MP0000383_abnormal_hair_follicle1.79617172
33MP0006035_abnormal_mitochondrial_morpho1.79381527
34MP0002332_abnormal_exercise_endurance1.77693398
35MP0000377_abnormal_hair_follicle1.77652025
36MP0000566_synostosis1.75598432
37MP0003693_abnormal_embryo_hatching1.75261609
38MP0001849_ear_inflammation1.66417834
39MP0002060_abnormal_skin_morphology1.63769871
40MP0003453_abnormal_keratinocyte_physiol1.60322933
41MP0002733_abnormal_thermal_nociception1.59342592
42MP0008260_abnormal_autophagy1.58886981
43MP0002653_abnormal_ependyma_morphology1.52515746
44MP0005058_abnormal_lysosome_morphology1.52208105
45MP0000427_abnormal_hair_cycle1.46697033
46MP0006292_abnormal_olfactory_placode1.43909831
47MP0010030_abnormal_orbit_morphology1.42999667
48MP0002277_abnormal_respiratory_mucosa1.41172884
49MP0002751_abnormal_autonomic_nervous1.39467202
50MP0008961_abnormal_basal_metabolism1.39414702
51MP0000678_abnormal_parathyroid_gland1.35863418
52MP0002148_abnormal_hypersensitivity_rea1.30858973
53MP0003566_abnormal_cell_adhesion1.28420737
54MP0000465_gastrointestinal_hemorrhage1.27014284
55MP0004185_abnormal_adipocyte_glucose1.26951174
56MP0003183_abnormal_peptide_metabolism1.22958292
57MP0004270_analgesia1.21535606
58MP0002095_abnormal_skin_pigmentation1.18742354
59MP0002234_abnormal_pharynx_morphology1.18708037
60MP0003938_abnormal_ear_development1.17716483
61MP0008932_abnormal_embryonic_tissue1.16216152
62MP0001672_abnormal_embryogenesis/_devel1.11436941
63MP0005380_embryogenesis_phenotype1.11436941
64MP0005377_hearing/vestibular/ear_phenot1.09190130
65MP0003878_abnormal_ear_physiology1.09190130
66MP0000685_abnormal_immune_system1.06955192
67MP0003806_abnormal_nucleotide_metabolis1.05137655
68MP0002734_abnormal_mechanical_nocicepti1.04962450
69MP0005257_abnormal_intraocular_pressure1.03606805
70MP0004043_abnormal_pH_regulation1.03393135
71MP0001348_abnormal_lacrimal_gland1.03086579
72MP0008789_abnormal_olfactory_epithelium1.01287272
73MP0008057_abnormal_DNA_replication0.99830426
74MP0005023_abnormal_wound_healing0.98958192
75MP0000350_abnormal_cell_proliferation0.97977168
76MP0002088_abnormal_embryonic_growth/wei0.97879416
77MP0001243_abnormal_dermal_layer0.97101084
78MP0003122_maternal_imprinting0.95494188
79MP0003984_embryonic_growth_retardation0.91995073
80MP0001970_abnormal_pain_threshold0.90961384
81MP0004947_skin_inflammation0.90201754
82MP0001851_eye_inflammation0.88316574
83MP0005409_darkened_coat_color0.88043539
84MP0009931_abnormal_skin_appearance0.86895325
85MP0004885_abnormal_endolymph0.86794598
86MP0000467_abnormal_esophagus_morphology0.86403962
87MP0002970_abnormal_white_adipose0.85780355
88MP0000367_abnormal_coat/_hair0.83113098
89MP0002132_abnormal_respiratory_system0.82691287
90MP0002233_abnormal_nose_morphology0.82664139
91MP0001873_stomach_inflammation0.82504721
92MP0002086_abnormal_extraembryonic_tissu0.79334672
93MP0003436_decreased_susceptibility_to0.78781588
94MP0009053_abnormal_anal_canal0.77994710
95MP0002085_abnormal_embryonic_tissue0.77978433
96MP0000858_altered_metastatic_potential0.77597830
97MP0003755_abnormal_palate_morphology0.77125897
98MP0001270_distended_abdomen0.77114639
99MP0003638_abnormal_response/metabolism_0.76848192
100MP0002127_abnormal_cardiovascular_syste0.76671163
101MP0004782_abnormal_surfactant_physiolog0.75811026
102MP0005408_hypopigmentation0.75494703
103MP0009785_altered_susceptibility_to0.75450961
104MP0005387_immune_system_phenotype0.74644649
105MP0001790_abnormal_immune_system0.74644649
106MP0000490_abnormal_crypts_of0.73320118
107MP0003077_abnormal_cell_cycle0.73214335
108MP0000749_muscle_degeneration0.73143815
109MP0002084_abnormal_developmental_patter0.71618508
110MP0005025_abnormal_response_to0.70322510
111MP0004019_abnormal_vitamin_homeostasis0.70069651
112MP0005508_abnormal_skeleton_morphology0.69812385
113MP0002932_abnormal_joint_morphology0.69748341
114MP0001730_embryonic_growth_arrest0.69657305
115MP0005266_abnormal_metabolism0.69397768
116MP0008770_decreased_survivor_rate0.68986720
117MP0003724_increased_susceptibility_to0.66121137
118MP0000627_abnormal_mammary_gland0.65042544
119MP0003763_abnormal_thymus_physiology0.64619800
120MP0009840_abnormal_foam_cell0.64546346
121MP0000538_abnormal_urinary_bladder0.64300829
122MP0001881_abnormal_mammary_gland0.63691793
123MP0003111_abnormal_nucleus_morphology0.63371447
124MP0000750_abnormal_muscle_regeneration0.63130130
125MP0005310_abnormal_salivary_gland0.60160961
126MP0009333_abnormal_splenocyte_physiolog0.60038962
127MP0000470_abnormal_stomach_morphology0.59902708
128MP0002249_abnormal_larynx_morphology0.59768680
129MP0002114_abnormal_axial_skeleton0.59686278
130MP0000432_abnormal_head_morphology0.58923936
131MP0001191_abnormal_skin_condition0.58919845
132MP0010155_abnormal_intestine_physiology0.58650112
133MP0009379_abnormal_foot_pigmentation0.58551219
134MP0006036_abnormal_mitochondrial_physio0.58352893
135MP0008872_abnormal_physiological_respon0.58249139
136MP0001533_abnormal_skeleton_physiology0.58135920
137MP0000358_abnormal_cell_content/0.57044812
138MP0002452_abnormal_antigen_presenting0.55824106
139MP0003172_abnormal_lysosome_physiology0.54725574
140MP0005000_abnormal_immune_tolerance0.52269629
141MP0002419_abnormal_innate_immunity0.51390058
142MP0002723_abnormal_immune_serum0.50617811
143MP0003075_altered_response_to0.47882568
144MP0001800_abnormal_humoral_immune0.46872678
145MP0003786_premature_aging0.45572262
146MP0001819_abnormal_immune_cell0.45127792
147MP0001764_abnormal_homeostasis0.44256824
148MP0001346_abnormal_lacrimal_gland0.43413941
149MP0002420_abnormal_adaptive_immunity0.43038366
150MP0001756_abnormal_urination0.42196656
151MP0009384_cardiac_valve_regurgitation0.41860659
152MP0006082_CNS_inflammation0.41808542
153MP0001340_abnormal_eyelid_morphology0.41631411
154MP0001845_abnormal_inflammatory_respons0.40348105
155MP0001188_hyperpigmentation0.39915425
156MP0008469_abnormal_protein_level0.39846746

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)6.73945059
2Bilateral microphthalmos (HP:0007633)6.23924048
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.87868836
4Erythroderma (HP:0001019)5.60938481
5Alopecia of scalp (HP:0002293)5.18610810
6Thick nail (HP:0001805)4.96412131
7Multiple enchondromatosis (HP:0005701)4.56104633
8Parakeratosis (HP:0001036)4.55193526
9Milia (HP:0001056)4.51024496
10Hypotrichosis (HP:0001006)4.18375674
11Abnormality of the lower motor neuron (HP:0002366)3.87089205
12Abnormal hair laboratory examination (HP:0003328)3.84646331
13Abnormality of the axillary hair (HP:0100134)3.75850841
14Abnormality of secondary sexual hair (HP:0009888)3.75850841
15Hypochromic microcytic anemia (HP:0004840)3.72384791
16Abnormal hemoglobin (HP:0011902)3.71325371
17Corneal erosion (HP:0200020)3.63674206
18Abnormal blistering of the skin (HP:0008066)3.56779139
19Rib fusion (HP:0000902)3.54817527
20Hepatoblastoma (HP:0002884)3.52761614
21Trismus (HP:0000211)3.41658732
22Lip pit (HP:0100267)3.40264080
23Sparse eyelashes (HP:0000653)3.39348230
24Curly hair (HP:0002212)3.32949483
25Testicular atrophy (HP:0000029)3.31144665
26Abnormality of nail color (HP:0100643)3.28032861
27Ependymoma (HP:0002888)3.24850365
28Increased IgE level (HP:0003212)3.24576626
29Ectropion (HP:0000656)3.24040066
30Abnormality of the salivary glands (HP:0010286)3.23350317
31Pustule (HP:0200039)3.16709143
32Amniotic constriction ring (HP:0009775)3.16098688
33Abnormality of placental membranes (HP:0011409)3.16098688
34Palmoplantar keratoderma (HP:0000982)2.99957935
35Increased connective tissue (HP:0009025)2.96756601
36Rhabdomyosarcoma (HP:0002859)2.94459788
37Hypohidrosis (HP:0000966)2.87253443
38Villous atrophy (HP:0011473)2.84737956
39Abnormality of small intestinal villus morphology (HP:0011472)2.84737956
40Nasolacrimal duct obstruction (HP:0000579)2.84728637
41Ridged nail (HP:0001807)2.81204931
42Aplasia/hypoplasia of the humerus (HP:0006507)2.80367665
43Partial duplication of thumb phalanx (HP:0009944)2.79120974
44Woolly hair (HP:0002224)2.77325557
45Premature ovarian failure (HP:0008209)2.75509053
46Neoplasm of striated muscle (HP:0009728)2.75191171
47Fasciculations (HP:0002380)2.74796087
48Bifid tongue (HP:0010297)2.74625122
49Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.73711048
50Abnormality of glycolipid metabolism (HP:0010969)2.72831149
51Abnormality of liposaccharide metabolism (HP:0010968)2.72831149
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.72831149
53Fused cervical vertebrae (HP:0002949)2.72294412
54Short humerus (HP:0005792)2.70359791
55Right ventricular cardiomyopathy (HP:0011663)2.67982324
56Conjunctival hamartoma (HP:0100780)2.66295512
57Malnutrition (HP:0004395)2.60448952
58Natal tooth (HP:0000695)2.59343841
59Follicular hyperkeratosis (HP:0007502)2.58748853
60Dysautonomia (HP:0002459)2.58692799
61Concave nail (HP:0001598)2.56555885
62Nail dystrophy (HP:0008404)2.54992439
63Gangrene (HP:0100758)2.53188360
64Abnormality of the distal phalanges of the toes (HP:0010182)2.52371221
65Upper limb muscle weakness (HP:0003484)2.50471099
66Congenital ichthyosiform erythroderma (HP:0007431)2.50094495
67Ragged-red muscle fibers (HP:0003200)2.49834457
68Muscle fibrillation (HP:0010546)2.49471593
69Tongue fasciculations (HP:0001308)2.49059328
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.48682050
71Hypoplasia of the fovea (HP:0007750)2.48682050
72Periauricular skin pits (HP:0100277)2.48377917
73Preauricular pit (HP:0004467)2.48377917
74Anomalous pulmonary venous return (HP:0010772)2.47293099
75Fragile nails (HP:0001808)2.45723219
76Rectovaginal fistula (HP:0000143)2.45355069
77Rectal fistula (HP:0100590)2.45355069
78Plantar hyperkeratosis (HP:0007556)2.44953214
79Onycholysis (HP:0001806)2.44376177
80Pili torti (HP:0003777)2.43400123
81Atrophic scars (HP:0001075)2.43076999
82Horizontal nystagmus (HP:0000666)2.41577063
83Progressive muscle weakness (HP:0003323)2.39161679
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35894651
85Difficulty running (HP:0009046)2.35131658
86Microretrognathia (HP:0000308)2.35048334
87Skin pits (HP:0100276)2.34656191
88Partial duplication of the phalanx of hand (HP:0009999)2.34324705
89Areflexia of lower limbs (HP:0002522)2.30145837
90Adenoma sebaceum (HP:0009720)2.29481150
91Angiofibromas (HP:0010615)2.29481150
92Sensory axonal neuropathy (HP:0003390)2.27661651
93Brittle hair (HP:0002299)2.27315341
94Abnormal cartilage morphology (HP:0002763)2.27270821
95Ventricular tachycardia (HP:0004756)2.26565672
96Dry hair (HP:0011359)2.25027675
97Abnormality of the lacrimal duct (HP:0011481)2.24612673
98Hyperhidrosis (HP:0000975)2.23552958
99Abnormal lung lobation (HP:0002101)2.23160007
100Erythema (HP:0010783)2.22699490
101Abnormality of the musculature of the hand (HP:0001421)2.21419635
102Distal lower limb muscle weakness (HP:0009053)2.19738208
103Intestinal fistula (HP:0100819)2.19286262
104Preauricular skin tag (HP:0000384)2.19120627
105Nephroblastoma (Wilms tumor) (HP:0002667)2.18754400
106Ulnar claw (HP:0001178)2.17495502
107Tetraplegia (HP:0002445)2.14523218
108Absent eyelashes (HP:0000561)2.14325180
109Palmoplantar hyperkeratosis (HP:0000972)2.13744627
110Impaired pain sensation (HP:0007328)2.08695518
111Abnormality of pain sensation (HP:0010832)2.08695518
112Sparse scalp hair (HP:0002209)2.07409947
113Astrocytoma (HP:0009592)2.06680526
114Abnormality of the astrocytes (HP:0100707)2.06680526
115Pruritus (HP:0000989)2.05515954
116Carious teeth (HP:0000670)2.05132765
117Vaginal fistula (HP:0004320)2.04651538
118Achilles tendon contracture (HP:0001771)2.02608850
119Hypoplasia of dental enamel (HP:0006297)2.02123919
120Selective tooth agenesis (HP:0001592)2.01972338
121Embryonal renal neoplasm (HP:0011794)2.01964272
122Palmar hyperkeratosis (HP:0010765)2.00122385
123Abnormality of the pulmonary veins (HP:0011718)1.99738262
124Furrowed tongue (HP:0000221)1.99700011
125EMG: neuropathic changes (HP:0003445)1.98898501
126Reduced antithrombin III activity (HP:0001976)1.98471788
127Advanced eruption of teeth (HP:0006288)1.98379439
128Shawl scrotum (HP:0000049)1.97733688
129Anonychia (HP:0001798)1.96263462
130Oligodontia (HP:0000677)1.95902615
131Cheilitis (HP:0100825)1.95209530
132Urticaria (HP:0001025)1.94707836
133Glossoptosis (HP:0000162)1.94611777
134Chromsome breakage (HP:0040012)1.92858618
135Aplasia/Hypoplasia of the scapulae (HP:0006713)1.92807966
136Hypoplastic scapulae (HP:0000882)1.92807966
137Amelogenesis imperfecta (HP:0000705)1.90450282
138Abnormality of the phalanges of the hallux (HP:0010057)1.90411558
139Generalized hypotonia (HP:0001290)1.90229841
140Amyotrophic lateral sclerosis (HP:0007354)1.89433271
141Abnormality of the fovea (HP:0000493)1.88771121
142Dehydration (HP:0001944)1.87214916
143Skin ulcer (HP:0200042)1.86635071
144Septate vagina (HP:0001153)1.85650397
145Recurrent bacterial skin infections (HP:0005406)1.84777446
146Eczematoid dermatitis (HP:0000976)1.82426668
147Absent hair (HP:0002298)1.82077849
148Congenital, generalized hypertrichosis (HP:0004540)1.81794329
149Hypergammaglobulinemia (HP:0010702)1.80513829
150Abnormality of hair growth rate (HP:0011363)1.79870589
151Slow-growing hair (HP:0002217)1.79870589
152Axonal loss (HP:0003447)1.79797896
153Blepharitis (HP:0000498)1.68809133
154Abnormal number of erythroid precursors (HP:0012131)1.67232933
155Verrucae (HP:0200043)1.66476559
156Papilloma (HP:0012740)1.66476559
157Seborrheic dermatitis (HP:0001051)1.63829250
158Acanthosis nigricans (HP:0000956)1.63057934
159Aplasia cutis congenita (HP:0001057)1.62578112
160Abnormality of the fingernails (HP:0001231)1.62560684
161Vacuolated lymphocytes (HP:0001922)1.60831719
162Popliteal pterygium (HP:0009756)1.59329940
163Abnormality of the neuromuscular junction (HP:0003398)1.59029435
164Fatigable weakness (HP:0003473)1.59029435
165Abnormality of cells of the erythroid lineage (HP:0012130)1.55270341
166Dysostosis multiplex (HP:0000943)1.54557675
167Fine hair (HP:0002213)1.53879034
168Abnormality of the dental root (HP:0006486)1.53474078
169Taurodontia (HP:0000679)1.53474078
170Abnormality of permanent molar morphology (HP:0011071)1.53474078
171Squamous cell carcinoma (HP:0002860)1.53161109
172Hypoplastic labia majora (HP:0000059)1.51686341
173Hypokinesia (HP:0002375)1.46320723
174Dry skin (HP:0000958)1.45090228
175Corneal dystrophy (HP:0001131)1.44830577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK56.24468479
2CDK126.09404588
3ERN13.85151390
4GRK63.57160169
5EPHA23.21669259
6GRK13.11590485
7ADRBK23.02815246
8VRK22.86024749
9MAPKAPK32.70404721
10SIK12.68234466
11MATK2.50642921
12TTK2.40225865
13IRAK32.40062634
14MST1R2.06083461
15NTRK12.03875366
16STK101.97356913
17SMG11.97138274
18MAP3K91.90832347
19TNK21.77741195
20RPS6KB21.74442233
21TGFBR21.72105324
22PRKD21.72069403
23TLK11.70499977
24PRKG21.70431855
25CSF1R1.66903203
26GRK71.66258398
27TGFBR11.65384001
28PBK1.64962144
29MST41.54607167
30AKT31.53379386
31IKBKB1.52538060
32LATS21.49626875
33MAPKAPK51.46496696
34MAPK71.46319640
35MOS1.45949133
36NME11.44666473
37TYRO31.44431969
38MAP3K61.43065592
39TESK21.40643567
40TRIB31.37771205
41TBK11.33375300
42ADRBK11.29522535
43TAF11.29483377
44IRAK21.29319021
45ABL21.24534795
46WNK11.22796037
47CDK71.21243568
48FGFR31.16545964
49MAP2K61.13659934
50MAP3K21.13274188
51MAP4K11.12395357
52STK161.12351318
53FER1.07288814
54MAP2K31.07206598
55IKBKE1.06146577
56EPHB11.04837587
57CAMK41.02592215
58MAP3K140.99306247
59HIPK20.98743416
60PAK40.98722593
61MAP4K20.96098954
62PIM20.93455230
63EIF2AK10.91033899
64LMTK20.90581925
65MAPK150.90240639
66MET0.89072518
67PRKCI0.88629942
68KSR20.88548874
69BUB10.88037964
70AURKA0.87411770
71MAP2K40.86547298
72PLK10.84007296
73ZAP700.82869211
74MARK20.82478999
75IRAK40.78003582
76MAP3K30.77750294
77FLT30.77307204
78CHEK20.77044391
79MAP3K130.76520431
80STK38L0.76370674
81PDK30.74901790
82PDK40.74901790
83MAP3K110.71424707
84LIMK10.70904463
85MAP2K20.66537755
86TYK20.65738984
87PTK20.64654971
88IRAK10.64471641
89CHUK0.60170144
90TAOK20.58846003
91NEK10.55501396
92EPHA30.55339690
93ARAF0.54777887
94MARK30.52732110
95AURKB0.52271622
96SIK30.52265255
97NME20.52130679
98BCKDK0.49581074
99MAP2K10.49246095
100AKT20.48568090
101BCR0.48554908
102MAP3K10.48060423
103STK240.48027084
104PTK60.47191620
105DYRK20.45814959
106LRRK20.43797283
107TRPM70.42669439
108RPS6KL10.41945912
109RPS6KC10.41945912
110STK380.41747373
111PDK20.41685821
112EPHB20.41338114
113CSK0.40479924
114TESK10.39617057
115PKN20.39600531
116EEF2K0.38260568
117JAK30.38116984
118CDC42BPA0.37825089
119CDK90.36667676
120RIPK40.35608485
121WEE10.35578452
122PAK10.35517849
123EIF2AK20.35393238
124CHEK10.34988502
125ERBB20.34594087
126FGR0.34051297
127ILK0.32817387
128CSNK1E0.32323591
129RPS6KA50.31982828
130VRK10.31277244
131MAPKAPK20.30992275
132HCK0.30817446
133RPS6KA60.30682860
134BMX0.30535730
135RPS6KA20.30252310
136TAOK10.29965841
137MTOR0.29660135
138MAPK120.29218760
139RPS6KA10.29044167
140PRKCD0.28660456
141IGF1R0.28012042
142NEK20.27939699
143MAP3K80.25522974
144ALK0.25062201
145BRAF0.24511139
146FRK0.23767549
147MINK10.22745454
148PIK3CG0.21168013
149YES10.20585319
150MAP3K70.17874866
151PRKACA0.16671605
152DYRK30.15638105
153PRKACG0.15423450
154ITK0.15287522
155CDK20.14772164
156SRPK10.12727016
157BLK0.12472601

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.35184627
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.49716252
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61689220
4Fructose and mannose metabolism_Homo sapiens_hsa000513.51477398
5Ribosome_Homo sapiens_hsa030103.28069608
6Oxidative phosphorylation_Homo sapiens_hsa001903.27237547
7Arachidonic acid metabolism_Homo sapiens_hsa005902.96682257
8Linoleic acid metabolism_Homo sapiens_hsa005912.81420746
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.67084580
10Thyroid cancer_Homo sapiens_hsa052162.67024996
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.64991850
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.45157527
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.33522070
14Lysosome_Homo sapiens_hsa041422.24045294
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.22458526
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19097401
17Parkinsons disease_Homo sapiens_hsa050122.16916849
18Galactose metabolism_Homo sapiens_hsa000522.16106749
19Collecting duct acid secretion_Homo sapiens_hsa049662.04945715
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92665750
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77192033
22Alzheimers disease_Homo sapiens_hsa050101.66711589
23Folate biosynthesis_Homo sapiens_hsa007901.53310635
24Vitamin digestion and absorption_Homo sapiens_hsa049771.53037961
25Renin-angiotensin system_Homo sapiens_hsa046141.47598353
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.47124265
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46748118
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45677721
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.42001335
30Sulfur relay system_Homo sapiens_hsa041221.40790225
31Huntingtons disease_Homo sapiens_hsa050161.40089181
32RNA transport_Homo sapiens_hsa030131.40069714
33RNA polymerase_Homo sapiens_hsa030201.33937543
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32807046
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29663047
36Vibrio cholerae infection_Homo sapiens_hsa051101.24878384
37Basal cell carcinoma_Homo sapiens_hsa052171.23539061
38Notch signaling pathway_Homo sapiens_hsa043301.21117434
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21049049
40Pentose phosphate pathway_Homo sapiens_hsa000301.20639081
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17082658
42mTOR signaling pathway_Homo sapiens_hsa041501.15373457
43Ovarian steroidogenesis_Homo sapiens_hsa049131.14443742
44Proteasome_Homo sapiens_hsa030501.12177083
45Bladder cancer_Homo sapiens_hsa052191.11388185
46Chemical carcinogenesis_Homo sapiens_hsa052041.10220731
47p53 signaling pathway_Homo sapiens_hsa041151.09495687
48Rheumatoid arthritis_Homo sapiens_hsa053231.07342084
49Ether lipid metabolism_Homo sapiens_hsa005651.06066187
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05172648
51Hedgehog signaling pathway_Homo sapiens_hsa043401.04994269
52Nucleotide excision repair_Homo sapiens_hsa034201.03868422
53Glycerolipid metabolism_Homo sapiens_hsa005610.99968360
54Hippo signaling pathway_Homo sapiens_hsa043900.99943459
55Tight junction_Homo sapiens_hsa045300.98980906
56Protein export_Homo sapiens_hsa030600.97817235
57Base excision repair_Homo sapiens_hsa034100.95058359
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.94828723
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93497774
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92350913
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91594578
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90418403
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.89770867
64Sphingolipid metabolism_Homo sapiens_hsa006000.89347084
65Regulation of autophagy_Homo sapiens_hsa041400.89195636
66Sulfur metabolism_Homo sapiens_hsa009200.88281854
67Tuberculosis_Homo sapiens_hsa051520.86066539
68Cell cycle_Homo sapiens_hsa041100.85252993
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79164653
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78824429
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78758243
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78271138
73Small cell lung cancer_Homo sapiens_hsa052220.77318620
74Taste transduction_Homo sapiens_hsa047420.75953315
75Mineral absorption_Homo sapiens_hsa049780.75402824
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72399230
77Inositol phosphate metabolism_Homo sapiens_hsa005620.72361978
78Carbon metabolism_Homo sapiens_hsa012000.72225532
79Fat digestion and absorption_Homo sapiens_hsa049750.72087342
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71971127
81N-Glycan biosynthesis_Homo sapiens_hsa005100.70794113
82Toxoplasmosis_Homo sapiens_hsa051450.70759785
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70649486
84Malaria_Homo sapiens_hsa051440.70312391
85Protein digestion and absorption_Homo sapiens_hsa049740.69458319
86Staphylococcus aureus infection_Homo sapiens_hsa051500.68774881
87Osteoclast differentiation_Homo sapiens_hsa043800.68637798
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68500809
89Fatty acid elongation_Homo sapiens_hsa000620.65687313
90VEGF signaling pathway_Homo sapiens_hsa043700.63474550
91Pathways in cancer_Homo sapiens_hsa052000.62988676
92Glutathione metabolism_Homo sapiens_hsa004800.62948560
93Legionellosis_Homo sapiens_hsa051340.61882835
94Shigellosis_Homo sapiens_hsa051310.58783254
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.58027087
96Epstein-Barr virus infection_Homo sapiens_hsa051690.56788416
97Melanoma_Homo sapiens_hsa052180.56429418
98Rap1 signaling pathway_Homo sapiens_hsa040150.55926709
99Amoebiasis_Homo sapiens_hsa051460.55347108
100Phototransduction_Homo sapiens_hsa047440.55134746
101Influenza A_Homo sapiens_hsa051640.54672462
102Salmonella infection_Homo sapiens_hsa051320.54600666
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53596004
104Choline metabolism in cancer_Homo sapiens_hsa052310.53483033
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53379157
106Other glycan degradation_Homo sapiens_hsa005110.52860389
107Fanconi anemia pathway_Homo sapiens_hsa034600.52507851
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52133137
109Retinol metabolism_Homo sapiens_hsa008300.51372970
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50874108
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50635076
112Herpes simplex infection_Homo sapiens_hsa051680.50397397
113Pyrimidine metabolism_Homo sapiens_hsa002400.50102355
114Acute myeloid leukemia_Homo sapiens_hsa052210.48452426
115TNF signaling pathway_Homo sapiens_hsa046680.48172477
116Adherens junction_Homo sapiens_hsa045200.43963476
117Spliceosome_Homo sapiens_hsa030400.42707699
118RNA degradation_Homo sapiens_hsa030180.42525453
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.42408593
120Phagosome_Homo sapiens_hsa041450.41598348
121Leishmaniasis_Homo sapiens_hsa051400.41231714
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40548335
123Metabolic pathways_Homo sapiens_hsa011000.40273578
124Endocytosis_Homo sapiens_hsa041440.40135434
125DNA replication_Homo sapiens_hsa030300.38864628
126Homologous recombination_Homo sapiens_hsa034400.38136974
127Pertussis_Homo sapiens_hsa051330.37998029
128Endometrial cancer_Homo sapiens_hsa052130.37798706
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36225949
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.35602520
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33821094
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33486492
133ABC transporters_Homo sapiens_hsa020100.32143802
134AMPK signaling pathway_Homo sapiens_hsa041520.30504267
135GnRH signaling pathway_Homo sapiens_hsa049120.30339926
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30255693
137Basal transcription factors_Homo sapiens_hsa030220.30174986
138Oocyte meiosis_Homo sapiens_hsa041140.29277939
139Proteoglycans in cancer_Homo sapiens_hsa052050.28955784
140MicroRNAs in cancer_Homo sapiens_hsa052060.28542755
141PPAR signaling pathway_Homo sapiens_hsa033200.28461401
142Non-small cell lung cancer_Homo sapiens_hsa052230.27323496
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27224762
144Hepatitis C_Homo sapiens_hsa051600.25456877
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24349202
146Primary immunodeficiency_Homo sapiens_hsa053400.24113458
147Ras signaling pathway_Homo sapiens_hsa040140.23496023
148Hematopoietic cell lineage_Homo sapiens_hsa046400.22691805
149Intestinal immune network for IgA production_Homo sapiens_hsa046720.21841496
150Mismatch repair_Homo sapiens_hsa034300.21789360
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21771728
152Cardiac muscle contraction_Homo sapiens_hsa042600.20991229
153Apoptosis_Homo sapiens_hsa042100.20707861
154Biosynthesis of amino acids_Homo sapiens_hsa012300.20492613
155RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20041318
156mRNA surveillance pathway_Homo sapiens_hsa030150.20018657
157Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18664623
158Tryptophan metabolism_Homo sapiens_hsa003800.17880003
159Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16894825

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