TMEM80

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleoside diphosphate catabolic process (GO:0009134)7.28376850
2preassembly of GPI anchor in ER membrane (GO:0016254)6.21036501
3ribosomal small subunit biogenesis (GO:0042274)5.33231386
4GPI anchor biosynthetic process (GO:0006506)5.31422053
5rRNA modification (GO:0000154)5.25398134
6protein-cofactor linkage (GO:0018065)5.03567083
7maturation of SSU-rRNA (GO:0030490)4.98762408
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.81198660
9viral transcription (GO:0019083)4.70010540
10DNA deamination (GO:0045006)4.68913039
11GPI anchor metabolic process (GO:0006505)4.67690606
12rRNA methylation (GO:0031167)4.64111308
13translational termination (GO:0006415)4.50427799
14cytochrome complex assembly (GO:0017004)4.44622536
15GTP biosynthetic process (GO:0006183)4.37148160
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.32401964
17termination of RNA polymerase III transcription (GO:0006386)4.32401964
18C-terminal protein lipidation (GO:0006501)4.29533565
19detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.25784265
20cotranslational protein targeting to membrane (GO:0006613)4.23170285
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22874414
22proteasome assembly (GO:0043248)4.18400267
23indole-containing compound catabolic process (GO:0042436)4.17087995
24indolalkylamine catabolic process (GO:0046218)4.17087995
25tryptophan catabolic process (GO:0006569)4.17087995
26protein targeting to ER (GO:0045047)4.15969611
27ATP synthesis coupled proton transport (GO:0015986)4.11389570
28energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11389570
297-methylguanosine mRNA capping (GO:0006370)4.04235588
30detection of light stimulus involved in visual perception (GO:0050908)3.98048929
31detection of light stimulus involved in sensory perception (GO:0050962)3.98048929
327-methylguanosine RNA capping (GO:0009452)3.95646128
33RNA capping (GO:0036260)3.95646128
34protein localization to endoplasmic reticulum (GO:0070972)3.94602604
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.93273363
36peptidyl-histidine modification (GO:0018202)3.93152547
37cellular response to electrical stimulus (GO:0071257)3.91886735
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.89206351
39chaperone-mediated protein transport (GO:0072321)3.85340546
40metallo-sulfur cluster assembly (GO:0031163)3.82117713
41iron-sulfur cluster assembly (GO:0016226)3.82117713
42axon ensheathment in central nervous system (GO:0032291)3.82117119
43central nervous system myelination (GO:0022010)3.82117119
44ribosomal large subunit biogenesis (GO:0042273)3.81401707
45L-fucose catabolic process (GO:0042355)3.80573699
46fucose catabolic process (GO:0019317)3.80573699
47L-fucose metabolic process (GO:0042354)3.80573699
48spliceosomal complex assembly (GO:0000245)3.73835998
49kynurenine metabolic process (GO:0070189)3.72674943
50C-terminal protein amino acid modification (GO:0018410)3.71522078
51translational elongation (GO:0006414)3.70908437
52translation (GO:0006412)3.66469450
53mannosylation (GO:0097502)3.66452221
54ribosomal small subunit assembly (GO:0000028)3.64288542
55behavioral response to nicotine (GO:0035095)3.63625665
56kinetochore assembly (GO:0051382)3.63311692
57regulation of nuclear cell cycle DNA replication (GO:0033262)3.63175082
58UTP biosynthetic process (GO:0006228)3.62540458
59spliceosomal snRNP assembly (GO:0000387)3.61139843
60tryptophan metabolic process (GO:0006568)3.58591025
61termination of RNA polymerase I transcription (GO:0006363)3.55545161
62respiratory electron transport chain (GO:0022904)3.55282082
63cellular protein complex disassembly (GO:0043624)3.55203814
64ribonucleoside diphosphate metabolic process (GO:0009185)3.52797596
65platelet dense granule organization (GO:0060155)3.52721598
66response to pheromone (GO:0019236)3.51997544
67telomere maintenance via semi-conservative replication (GO:0032201)3.51835442
68protein neddylation (GO:0045116)3.51705892
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50792888
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50501232
71transcription from RNA polymerase I promoter (GO:0006360)3.48491754
72CENP-A containing nucleosome assembly (GO:0034080)3.47991322
73electron transport chain (GO:0022900)3.47665624
74transcription elongation from RNA polymerase I promoter (GO:0006362)3.47431524
75protein complex biogenesis (GO:0070271)3.47298567
76viral life cycle (GO:0019058)3.45602476
77mitochondrial respiratory chain complex I assembly (GO:0032981)3.44441250
78NADH dehydrogenase complex assembly (GO:0010257)3.44441250
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44441250
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.43845759
81tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.43845759
82transcription-coupled nucleotide-excision repair (GO:0006283)3.43099595
83ribonucleoprotein complex biogenesis (GO:0022613)3.42320890
84establishment of viral latency (GO:0019043)3.41272413
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40032868
86nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39586462
87pseudouridine synthesis (GO:0001522)3.38548375
88guanosine-containing compound biosynthetic process (GO:1901070)3.37983672
89DNA damage response, detection of DNA damage (GO:0042769)3.34170699
90nucleoside diphosphate metabolic process (GO:0009132)3.31846753
91chromatin remodeling at centromere (GO:0031055)3.31314451
92piRNA metabolic process (GO:0034587)3.30592481
93protein targeting to mitochondrion (GO:0006626)3.30060039
94S-adenosylmethionine metabolic process (GO:0046500)3.29177922
95adenosine metabolic process (GO:0046085)3.24207882
96cellular component biogenesis (GO:0044085)3.22615745
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21677914
98mitochondrial respiratory chain complex assembly (GO:0033108)3.21215365
99water-soluble vitamin biosynthetic process (GO:0042364)3.20302369
100establishment of integrated proviral latency (GO:0075713)3.19875711
101translational initiation (GO:0006413)3.19293807
102respiratory chain complex IV assembly (GO:0008535)3.18713466
103deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.17425061
104indolalkylamine metabolic process (GO:0006586)3.17029525
105UTP metabolic process (GO:0046051)3.16020116
106rRNA processing (GO:0006364)3.14843791
107establishment of protein localization to mitochondrion (GO:0072655)3.11625739
108pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.10948189
109CTP biosynthetic process (GO:0006241)3.08422000
110CTP metabolic process (GO:0046036)3.08422000
111transcription initiation from RNA polymerase I promoter (GO:0006361)3.05893455
112tongue development (GO:0043586)3.05710455
113kinetochore organization (GO:0051383)3.02269129
114positive regulation of protein homodimerization activity (GO:0090073)3.01508469
115phosphatidylinositol acyl-chain remodeling (GO:0036149)2.99956031
116telomere maintenance via recombination (GO:0000722)2.99675438
117protein complex disassembly (GO:0043241)2.99251982
118rRNA metabolic process (GO:0016072)2.98848315
119regulation of mitochondrial translation (GO:0070129)2.97512302
120pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.96916757
121sequestering of actin monomers (GO:0042989)2.96666983
122base-excision repair, AP site formation (GO:0006285)2.93719143
123pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92637608
124positive regulation of fatty acid transport (GO:2000193)2.90784842
125amino acid salvage (GO:0043102)2.86210079
126L-methionine salvage (GO:0071267)2.86210079
127L-methionine biosynthetic process (GO:0071265)2.86210079
128amine catabolic process (GO:0009310)2.85473026
129cellular biogenic amine catabolic process (GO:0042402)2.85473026
130ubiquinone biosynthetic process (GO:0006744)2.82581065
131epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81037759
132valine metabolic process (GO:0006573)2.78703563
133adaptation of signaling pathway (GO:0023058)2.78440140
134positive regulation of prostaglandin secretion (GO:0032308)2.74525466
135cornea development in camera-type eye (GO:0061303)2.72472385
136negative regulation of telomere maintenance (GO:0032205)2.72213827
137axoneme assembly (GO:0035082)2.72132215
138detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70796343
139regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70439815
140organic cation transport (GO:0015695)2.70269242
141negative regulation of mast cell activation (GO:0033004)2.67569691
142aromatic amino acid family catabolic process (GO:0009074)2.67504416
143autophagic vacuole fusion (GO:0000046)2.66691184
144inositol phosphate catabolic process (GO:0071545)2.66426063
145positive regulation of icosanoid secretion (GO:0032305)2.66242910
146nucleotide transmembrane transport (GO:1901679)2.63862484
147protein localization to cilium (GO:0061512)2.63421906
148positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.63191537
149purinergic nucleotide receptor signaling pathway (GO:0035590)2.60868896
150phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.59693070
151phosphorylated carbohydrate dephosphorylation (GO:0046838)2.58650989
152inositol phosphate dephosphorylation (GO:0046855)2.58650989
153regulation of memory T cell differentiation (GO:0043380)2.58497683
154protein deneddylation (GO:0000338)2.54086826
155cullin deneddylation (GO:0010388)2.53874704
156mitotic cell cycle arrest (GO:0071850)2.53654504
157phosphatidylglycerol biosynthetic process (GO:0006655)2.52061759
158glycolipid biosynthetic process (GO:0009247)2.51078767
159negative regulation of interleukin-1 production (GO:0032692)2.49281459
160regulation of cilium movement (GO:0003352)2.49181048
161GMP metabolic process (GO:0046037)2.48759603
162regulation of hexokinase activity (GO:1903299)2.48024853
163regulation of glucokinase activity (GO:0033131)2.48024853
164epithelial cilium movement (GO:0003351)2.47249573
165aggressive behavior (GO:0002118)2.46252607
166indole-containing compound metabolic process (GO:0042430)2.46143037
167nitric oxide mediated signal transduction (GO:0007263)2.45849397
168ubiquinone metabolic process (GO:0006743)2.44252837
169positive regulation of T-helper 1 type immune response (GO:0002827)2.44011548
170branched-chain amino acid catabolic process (GO:0009083)2.42866905
171cellular ketone body metabolic process (GO:0046950)2.42404417
172negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.41305691
173positive regulation of defense response to virus by host (GO:0002230)2.41129039
174regulation of B cell apoptotic process (GO:0002902)2.38983188
175quinone biosynthetic process (GO:1901663)2.38149068
176basic amino acid transport (GO:0015802)2.35470882
177NAD biosynthetic process (GO:0009435)2.33930572
178nonmotile primary cilium assembly (GO:0035058)2.32155173
179DNA methylation involved in gamete generation (GO:0043046)2.30933662
180branched-chain amino acid metabolic process (GO:0009081)2.30688641
181phosphatidylserine acyl-chain remodeling (GO:0036150)2.30651535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.88964036
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.33900995
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.22811233
4ZNF274_21170338_ChIP-Seq_K562_Hela4.12032642
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.98743606
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.86217745
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68851568
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.58492637
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.48845456
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.48733697
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.46080928
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.43757472
13* MYC_18555785_ChIP-Seq_MESCs_Mouse3.41019570
14IRF8_22096565_ChIP-ChIP_GC-B_Human3.33032555
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25015399
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80360695
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50757265
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49078307
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48727610
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.40642961
21VDR_23849224_ChIP-Seq_CD4+_Human2.32848763
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31802036
23E2F7_22180533_ChIP-Seq_HELA_Human2.26995084
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13460512
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.06969596
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.05571101
27FOXP3_21729870_ChIP-Seq_TREG_Human2.05431903
28XRN2_22483619_ChIP-Seq_HELA_Human2.00260419
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96017696
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.96012462
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94005371
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93563240
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91513686
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85970935
35* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85561465
36ELK1_19687146_ChIP-ChIP_HELA_Human1.85214665
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.81820963
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80868844
39DCP1A_22483619_ChIP-Seq_HELA_Human1.78289038
40IRF1_19129219_ChIP-ChIP_H3396_Human1.77855932
41TTF2_22483619_ChIP-Seq_HELA_Human1.77492470
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76547422
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75219681
44TP53_22573176_ChIP-Seq_HFKS_Human1.75186576
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66109156
46ERA_21632823_ChIP-Seq_H3396_Human1.61312150
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61202847
48* FOXA1_25329375_ChIP-Seq_VCAP_Human1.57472368
49* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.57472368
50AR_20517297_ChIP-Seq_VCAP_Human1.55926272
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.55299073
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.52975121
53GATA3_26560356_Chip-Seq_TH2_Human1.49809332
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49062341
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49062341
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49062341
57BCL6_27268052_Chip-Seq_Bcells_Human1.46157674
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.46038737
59TAF2_19829295_ChIP-Seq_ESCs_Human1.43753583
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42830922
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42210598
62GBX2_23144817_ChIP-Seq_PC3_Human1.42146790
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41389741
64* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.41162269
65EWS_26573619_Chip-Seq_HEK293_Human1.41054198
66MYC_19829295_ChIP-Seq_ESCs_Human1.40404641
67NANOG_20526341_ChIP-Seq_ESCs_Human1.39759107
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39465193
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37557197
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36968902
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36737731
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35457082
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.34714390
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34561233
75GABP_19822575_ChIP-Seq_HepG2_Human1.33976065
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33039530
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32450035
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32249496
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31632477
80NCOR_22424771_ChIP-Seq_293T_Human1.31115052
81EZH2_22144423_ChIP-Seq_EOC_Human1.30440653
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29949276
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29529832
84OCT4_20526341_ChIP-Seq_ESCs_Human1.28745510
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.28098542
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27345931
87HOXB7_26014856_ChIP-Seq_BT474_Human1.26769730
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26622493
89ER_23166858_ChIP-Seq_MCF-7_Human1.25942958
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25835742
91E2F1_20622854_ChIP-Seq_HELA_Human1.25320386
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.25170885
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24841076
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24383189
95BCAT_22108803_ChIP-Seq_LS180_Human1.21622899
96* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21447075
97MYC_18940864_ChIP-ChIP_HL60_Human1.20541464
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20282165
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20265777
100TAF15_26573619_Chip-Seq_HEK293_Human1.19675132
101* FOXH1_21741376_ChIP-Seq_ESCs_Human1.19354045
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18987305
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18637286
104RAC3_21632823_ChIP-Seq_H3396_Human1.16483642
105BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16306700
106CIITA_25753668_ChIP-Seq_RAJI_Human1.15511408
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15395143
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15280568
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14924723
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14568895
111P300_27268052_Chip-Seq_Bcells_Human1.14427149
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14195583
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12896311
114P53_21459846_ChIP-Seq_SAOS-2_Human1.11745972
115STAT1_20625510_ChIP-Seq_HELA_Human1.11204424
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11197989
117FOXH1_21741376_ChIP-Seq_EPCs_Human1.10037689
118* PHF8_20622854_ChIP-Seq_HELA_Human1.08388587
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07739819
120VDR_22108803_ChIP-Seq_LS180_Human1.07103460
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07058061
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06410731
123CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06177316
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05538273
125CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03480044
126BCOR_27268052_Chip-Seq_Bcells_Human1.02296376
127ELF1_20517297_ChIP-Seq_JURKAT_Human1.01755007
128GATA3_27048872_Chip-Seq_THYMUS_Human1.01574100
129RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00749853
130* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99156651
131FLI1_27457419_Chip-Seq_LIVER_Mouse0.98677874
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98621384
133ERG_20517297_ChIP-Seq_VCAP_Human0.98567249
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98155834
135SALL1_21062744_ChIP-ChIP_HESCs_Human0.97534801
136NANOG_19829295_ChIP-Seq_ESCs_Human0.97508409
137SOX2_19829295_ChIP-Seq_ESCs_Human0.97508409
138PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97351444
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96652749
140NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96110792
141* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95985792
142REST_21632747_ChIP-Seq_MESCs_Mouse0.94930669
143MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94853489
144SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91247847
145SOX2_16153702_ChIP-ChIP_HESCs_Human0.90779650
146IGF1R_20145208_ChIP-Seq_DFB_Human0.90693289
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86441570
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.86257754
149SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82263420
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81946749
151PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81902756
152ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80426184
153NANOG_16153702_ChIP-ChIP_HESCs_Human0.80014211
154CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79775550
155* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79656425
156SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77773653
157FUS_26573619_Chip-Seq_HEK293_Human0.74079621
158NFE2_27457419_Chip-Seq_LIVER_Mouse0.73380807
159GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72054029
160SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71617715
161KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70377211
162POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.70034804
163FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69358825
164* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.69262664
165SUZ12_27294783_Chip-Seq_NPCs_Mouse0.68224974
166SOX17_20123909_ChIP-Seq_XEN_Mouse0.67130448
167* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.64308370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.45382263
2MP0005423_abnormal_somatic_nervous6.32856226
3MP0000566_synostosis4.47063038
4MP0009379_abnormal_foot_pigmentation4.39258111
5MP0003136_yellow_coat_color3.89631679
6MP0004145_abnormal_muscle_electrophysio3.55770765
7MP0008875_abnormal_xenobiotic_pharmacok3.28298061
8MP0006292_abnormal_olfactory_placode2.98966686
9MP0001188_hyperpigmentation2.78070098
10MP0004147_increased_porphyrin_level2.55946583
11MP0002837_dystrophic_cardiac_calcinosis2.46911937
12MP0003195_calcinosis2.46560201
13MP0002638_abnormal_pupillary_reflex2.33931517
14MP0002102_abnormal_ear_morphology2.33802156
15MP0003880_abnormal_central_pattern2.31580958
16MP0002653_abnormal_ependyma_morphology2.25332276
17MP0004381_abnormal_hair_follicle2.18131382
18MP0004133_heterotaxia2.17202171
19MP0008058_abnormal_DNA_repair1.96973363
20MP0001529_abnormal_vocalization1.92030830
21MP0005409_darkened_coat_color1.86921123
22MP0002163_abnormal_gland_morphology1.79386411
23MP0003693_abnormal_embryo_hatching1.78206391
24MP0005671_abnormal_response_to1.78118530
25MP0008057_abnormal_DNA_replication1.72995402
26MP0008872_abnormal_physiological_respon1.72422628
27MP0003646_muscle_fatigue1.69264605
28MP0005084_abnormal_gallbladder_morpholo1.67513264
29MP0005379_endocrine/exocrine_gland_phen1.62983143
30MP0000685_abnormal_immune_system1.57685710
31MP0003718_maternal_effect1.56795623
32MP0004142_abnormal_muscle_tone1.54377068
33MP0008789_abnormal_olfactory_epithelium1.53175110
34MP0005171_absent_coat_pigmentation1.51208810
35MP0001905_abnormal_dopamine_level1.50097994
36MP0000372_irregular_coat_pigmentation1.49646694
37MP0001984_abnormal_olfaction1.47520837
38MP0006276_abnormal_autonomic_nervous1.47426317
39MP0005253_abnormal_eye_physiology1.41774585
40MP0006072_abnormal_retinal_apoptosis1.41540971
41MP0005551_abnormal_eye_electrophysiolog1.40885853
42MP0005332_abnormal_amino_acid1.37211590
43MP0002138_abnormal_hepatobiliary_system1.36938257
44MP0003111_abnormal_nucleus_morphology1.36061052
45MP0008877_abnormal_DNA_methylation1.32026008
46MP0002132_abnormal_respiratory_system1.31515717
47MP0001835_abnormal_antigen_presentation1.30670809
48MP0005499_abnormal_olfactory_system1.30096721
49MP0005394_taste/olfaction_phenotype1.30096721
50MP0002148_abnormal_hypersensitivity_rea1.29792258
51MP0010329_abnormal_lipoprotein_level1.28097765
52MP0008932_abnormal_embryonic_tissue1.27674642
53MP0001800_abnormal_humoral_immune1.27656464
54MP0003252_abnormal_bile_duct1.26183570
55MP0009764_decreased_sensitivity_to1.26170173
56MP0005387_immune_system_phenotype1.20728518
57MP0001790_abnormal_immune_system1.20728518
58MP0001485_abnormal_pinna_reflex1.19686964
59MP0002277_abnormal_respiratory_mucosa1.18972392
60MP0003806_abnormal_nucleotide_metabolis1.18139631
61MP0002272_abnormal_nervous_system1.17788362
62MP0001501_abnormal_sleep_pattern1.16857255
63MP0009785_altered_susceptibility_to1.15967584
64MP0010386_abnormal_urinary_bladder1.15598581
65MP0003011_delayed_dark_adaptation1.14150738
66MP0004742_abnormal_vestibular_system1.13663842
67MP0001764_abnormal_homeostasis1.12734889
68MP0002693_abnormal_pancreas_physiology1.12487952
69MP0003186_abnormal_redox_activity1.11546656
70MP0002723_abnormal_immune_serum1.10842627
71MP0002928_abnormal_bile_duct1.10817415
72MP0000427_abnormal_hair_cycle1.10494452
73MP0000230_abnormal_systemic_arterial1.10031331
74MP0003436_decreased_susceptibility_to1.09595536
75MP0005000_abnormal_immune_tolerance1.09289118
76MP0002733_abnormal_thermal_nociception1.09068075
77MP0005174_abnormal_tail_pigmentation1.08957321
78MP0001486_abnormal_startle_reflex1.08770770
79MP0004885_abnormal_endolymph1.08485884
80MP0003941_abnormal_skin_development1.07218493
81MP0003045_fibrosis1.06590274
82MP0003183_abnormal_peptide_metabolism1.06527021
83MP0005075_abnormal_melanosome_morpholog1.05262175
84MP0008007_abnormal_cellular_replicative1.00901772
85MP0005636_abnormal_mineral_homeostasis0.99872811
86MP0002938_white_spotting0.99522097
87MP0001765_abnormal_ion_homeostasis0.98809490
88MP0002751_abnormal_autonomic_nervous0.98345927
89MP0003786_premature_aging0.96798598
90MP0008775_abnormal_heart_ventricle0.95323815
91MP0002254_reproductive_system_inflammat0.93548040
92MP0008260_abnormal_autophagy0.92399096
93MP0003077_abnormal_cell_cycle0.91668060
94MP0002210_abnormal_sex_determination0.91518202
95MP0002452_abnormal_antigen_presenting0.91024140
96MP0010094_abnormal_chromosome_stability0.90777334
97MP0000569_abnormal_digit_pigmentation0.90678603
98MP0001819_abnormal_immune_cell0.89675557
99MP0002095_abnormal_skin_pigmentation0.89670264
100MP0002420_abnormal_adaptive_immunity0.88810188
101MP0002160_abnormal_reproductive_system0.87597369
102MP0008995_early_reproductive_senescence0.87322390
103MP0002909_abnormal_adrenal_gland0.86836038
104MP0005408_hypopigmentation0.86805301
105MP0002752_abnormal_somatic_nervous0.86092675
106MP0001756_abnormal_urination0.85984745
107MP0001533_abnormal_skeleton_physiology0.85185734
108MP0005167_abnormal_blood-brain_barrier0.84122023
109MP0005646_abnormal_pituitary_gland0.83803654
110MP0000920_abnormal_myelination0.83236634
111MP0001873_stomach_inflammation0.82708220
112MP0006036_abnormal_mitochondrial_physio0.82075734
113MP0001944_abnormal_pancreas_morphology0.81293447
114MP0009643_abnormal_urine_homeostasis0.81173230
115MP0009046_muscle_twitch0.80453821
116MP0005389_reproductive_system_phenotype0.78861304
117MP0003172_abnormal_lysosome_physiology0.78823762
118MP0002229_neurodegeneration0.78555703
119MP0000778_abnormal_nervous_system0.78490400
120MP0005395_other_phenotype0.78013066
121MP0005310_abnormal_salivary_gland0.77773591
122MP0004957_abnormal_blastocyst_morpholog0.77727390
123MP0005645_abnormal_hypothalamus_physiol0.76689746
124MP0000026_abnormal_inner_ear0.76246232
125MP0008469_abnormal_protein_level0.75417415
126MP0005025_abnormal_response_to0.75391417
127MP0002184_abnormal_innervation0.73913606
128MP0002734_abnormal_mechanical_nocicepti0.73618149
129MP0000762_abnormal_tongue_morphology0.73281229
130MP0000015_abnormal_ear_pigmentation0.73108819
131MP0005220_abnormal_exocrine_pancreas0.72017333
132MP0000631_abnormal_neuroendocrine_gland0.71698296
133MP0005365_abnormal_bile_salt0.69806992
134MP0000613_abnormal_salivary_gland0.69725970
135MP0001963_abnormal_hearing_physiology0.69297378
136MP0009745_abnormal_behavioral_response0.68213991
137MP0002735_abnormal_chemical_nociception0.67873299
138MP0001929_abnormal_gametogenesis0.67375049
139MP0001145_abnormal_male_reproductive0.66682466
140MP0003724_increased_susceptibility_to0.66664155
141MP0003698_abnormal_male_reproductive0.66131438
142MP0005670_abnormal_white_adipose0.65913465
143MP0005391_vision/eye_phenotype0.65800115
144MP0003938_abnormal_ear_development0.65497517
145MP0001970_abnormal_pain_threshold0.64798221
146MP0003283_abnormal_digestive_organ0.64775681
147MP0004043_abnormal_pH_regulation0.64390194
148MP0000653_abnormal_sex_gland0.64148115
149MP0002064_seizures0.63072916
150MP0001968_abnormal_touch/_nociception0.62935072
151MP0005410_abnormal_fertilization0.62516309
152MP0003890_abnormal_embryonic-extraembry0.60130645
153MP0002736_abnormal_nociception_after0.58626432
154MP0005195_abnormal_posterior_eye0.58474133
155MP0002882_abnormal_neuron_morphology0.58246478
156MP0002876_abnormal_thyroid_physiology0.58111189
157MP0002067_abnormal_sensory_capabilities0.56147193

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)9.03636853
2Abnormality of the renal collecting system (HP:0004742)8.01834554
3Long foot (HP:0001833)5.93521939
4Acute lymphatic leukemia (HP:0006721)5.42154002
5Hypoplastic nipples (HP:0002557)5.01747595
6Large for gestational age (HP:0001520)4.94788468
7Pulmonary artery stenosis (HP:0004415)4.57066716
8Congenital stationary night blindness (HP:0007642)4.56365647
9Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.40879708
10Adactyly (HP:0009776)4.15891857
11Ureteral duplication (HP:0000073)4.10440145
12Abnormality of midbrain morphology (HP:0002418)3.92266076
13Molar tooth sign on MRI (HP:0002419)3.92266076
14Broad-based gait (HP:0002136)3.63157293
15Acute necrotizing encephalopathy (HP:0006965)3.59909892
16Nephronophthisis (HP:0000090)3.55453085
17Stomatitis (HP:0010280)3.52277630
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.47202890
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39263057
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39263057
21Renal Fanconi syndrome (HP:0001994)3.32576755
22Mitochondrial inheritance (HP:0001427)3.26971509
23Increased intramyocellular lipid droplets (HP:0012240)3.18168005
24Ureteral stenosis (HP:0000071)3.17768832
25Abnormal ventriculo-arterial connection (HP:0011563)3.08526907
26Transposition of the great arteries (HP:0001669)3.08526907
27Abnormal connection of the cardiac segments (HP:0011545)3.08526907
28Increased hepatocellular lipid droplets (HP:0006565)3.08168875
29Abnormality of cells of the erythroid lineage (HP:0012130)3.06878779
30Attenuation of retinal blood vessels (HP:0007843)3.04299621
31Decreased electroretinogram (ERG) amplitude (HP:0000654)3.02193128
32Abnormal mitochondria in muscle tissue (HP:0008316)3.00057927
33Reticulocytopenia (HP:0001896)2.97873587
34Ureteral obstruction (HP:0006000)2.97234827
353-Methylglutaconic aciduria (HP:0003535)2.96626855
36Abnormal number of erythroid precursors (HP:0012131)2.91556578
37Abnormality of the renal medulla (HP:0100957)2.88697470
38Breast hypoplasia (HP:0003187)2.86738199
39Progressive macrocephaly (HP:0004481)2.83142090
40Clubbing of toes (HP:0100760)2.82191296
41Acute encephalopathy (HP:0006846)2.81813639
42Macrocytic anemia (HP:0001972)2.79385577
43Abnormality of the renal cortex (HP:0011035)2.78707605
44Increased CSF lactate (HP:0002490)2.78252291
45Progressive external ophthalmoplegia (HP:0000590)2.78220956
46Hepatocellular necrosis (HP:0001404)2.75308220
47Abnormal drinking behavior (HP:0030082)2.70819401
48Polydipsia (HP:0001959)2.70819401
49Lipid accumulation in hepatocytes (HP:0006561)2.60871702
50Overfolded helix (HP:0000396)2.56007814
51Increased muscle lipid content (HP:0009058)2.55310063
52Exercise intolerance (HP:0003546)2.54679526
53Elevated erythrocyte sedimentation rate (HP:0003565)2.51875145
54Increased serum lactate (HP:0002151)2.50075025
55Cystic liver disease (HP:0006706)2.47414306
56Abnormality of alanine metabolism (HP:0010916)2.46095293
57Hyperalaninemia (HP:0003348)2.46095293
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46095293
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45538679
60Methylmalonic acidemia (HP:0002912)2.38871600
61Abolished electroretinogram (ERG) (HP:0000550)2.38805830
62Tubular atrophy (HP:0000092)2.37132177
63Concave nail (HP:0001598)2.34643126
64Exertional dyspnea (HP:0002875)2.33841966
65Methylmalonic aciduria (HP:0012120)2.33404491
66Hepatic necrosis (HP:0002605)2.31737143
67Cerebral hypomyelination (HP:0006808)2.30317070
68Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.26345828
69Optic disc pallor (HP:0000543)2.25724936
70Conical tooth (HP:0000698)2.25165535
71Bile duct proliferation (HP:0001408)2.24322155
72Abnormal biliary tract physiology (HP:0012439)2.24322155
73Aplasia/Hypoplasia of the nipples (HP:0006709)2.23541988
74Leukodystrophy (HP:0002415)2.22689698
75Pallor (HP:0000980)2.22157917
76Severe combined immunodeficiency (HP:0004430)2.21601347
77Increased number of teeth (HP:0011069)2.20857411
78Abnormality of renal resorption (HP:0011038)2.19633983
79Abnormally folded helix (HP:0008544)2.19509015
80Renal cortical cysts (HP:0000803)2.19389987
81True hermaphroditism (HP:0010459)2.19298674
82Abnormal ciliary motility (HP:0012262)2.17948472
83Birth length less than 3rd percentile (HP:0003561)2.16773424
84Respiratory difficulties (HP:0002880)2.16613950
85Parakeratosis (HP:0001036)2.16531987
86Hyperventilation (HP:0002883)2.15864492
87Abnormal rod and cone electroretinograms (HP:0008323)2.15242685
88Congenital sensorineural hearing impairment (HP:0008527)2.14360127
89Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11455876
90Ketoacidosis (HP:0001993)2.11224052
91Congenital hepatic fibrosis (HP:0002612)2.06945181
92Absent speech (HP:0001344)2.05970173
93Microvesicular hepatic steatosis (HP:0001414)2.05639140
94Type II lissencephaly (HP:0007260)2.04654533
95Abnormal glycosylation (HP:0012345)2.04524804
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04524804
97Abnormal protein N-linked glycosylation (HP:0012347)2.04524804
98Abnormal protein glycosylation (HP:0012346)2.04524804
99Polyuria (HP:0000103)2.03821172
100Type I transferrin isoform profile (HP:0003642)2.03199217
101Decreased circulating renin level (HP:0003351)2.03025399
102Ketosis (HP:0001946)2.02601830
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00567756
104Testicular atrophy (HP:0000029)2.00416504
105Constricted visual fields (HP:0001133)1.97798971
106IgG deficiency (HP:0004315)1.97724058
107Lactic acidosis (HP:0003128)1.97638734
108Pancreatic cysts (HP:0001737)1.97456294
109Pancreatic fibrosis (HP:0100732)1.96886080
110Myositis (HP:0100614)1.96513583
111Hyperglycinuria (HP:0003108)1.94962333
112Panhypogammaglobulinemia (HP:0003139)1.94769245
113Large hands (HP:0001176)1.94139239
114Abnormal respiratory motile cilium physiology (HP:0012261)1.92653237
115Furrowed tongue (HP:0000221)1.92168648
116Absent/shortened dynein arms (HP:0200106)1.91273616
117Dynein arm defect of respiratory motile cilia (HP:0012255)1.91273616
118Abnormal respiratory epithelium morphology (HP:0012253)1.90973071
119Abnormal respiratory motile cilium morphology (HP:0005938)1.90973071
120Inability to walk (HP:0002540)1.90862759
121Abnormality of the axillary hair (HP:0100134)1.90714591
122Abnormality of secondary sexual hair (HP:0009888)1.90714591
123Thyroiditis (HP:0100646)1.90423326
124Pendular nystagmus (HP:0012043)1.90315405
125Chronic hepatic failure (HP:0100626)1.89792285
126Decreased central vision (HP:0007663)1.89784861
127Tachypnea (HP:0002789)1.89017013
128Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88660400
129Dicarboxylic aciduria (HP:0003215)1.88660400
130Abnormal delayed hypersensitivity skin test (HP:0002963)1.88109402
131Mesangial abnormality (HP:0001966)1.88004067
132Hypomagnesemia (HP:0002917)1.87709482
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.87449399
134Medial flaring of the eyebrow (HP:0010747)1.86437265
135Sclerocornea (HP:0000647)1.85059819
136Chromsome breakage (HP:0040012)1.83697952
137Progressive inability to walk (HP:0002505)1.82974973
138Respiratory failure (HP:0002878)1.82839231
139Aplastic anemia (HP:0001915)1.81985488
140Chorioretinal coloboma (HP:0000567)1.81757840
141Anencephaly (HP:0002323)1.80296264
142Depressed nasal ridge (HP:0000457)1.78764097
143Septo-optic dysplasia (HP:0100842)1.77208156
144Progressive microcephaly (HP:0000253)1.77203117
145Aplasia/hypoplasia of the uterus (HP:0008684)1.76171021
146Stomach cancer (HP:0012126)1.74566978
147Agammaglobulinemia (HP:0004432)1.74080207
148Postaxial foot polydactyly (HP:0001830)1.73735424
149Supernumerary spleens (HP:0009799)1.73690183
150Cerebral edema (HP:0002181)1.71288421
151Lethargy (HP:0001254)1.70978197
152Disproportionate short-trunk short stature (HP:0003521)1.70901411
153Abnormality of eosinophils (HP:0001879)1.69368362
154Cortical visual impairment (HP:0100704)1.69334270
155Widely spaced teeth (HP:0000687)1.67700629
156Abnormality of the preputium (HP:0100587)1.63819186
157Gait imbalance (HP:0002141)1.62716985
158Male pseudohermaphroditism (HP:0000037)1.62394538
159Congenital primary aphakia (HP:0007707)1.61914690
160External ophthalmoplegia (HP:0000544)1.61641273
161Triphalangeal thumb (HP:0001199)1.60729423
162Abnormality of the septum pellucidum (HP:0007375)1.59890207
163Nephrogenic diabetes insipidus (HP:0009806)1.59355329
164Absent septum pellucidum (HP:0001331)1.57841000
165Oral leukoplakia (HP:0002745)1.57556192
166Hypothermia (HP:0002045)1.57276738
167Absent radius (HP:0003974)1.57166370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.95963581
2STK164.53454627
3IRAK33.56854277
4NUAK13.36600010
5MAP4K23.14236451
6CDC42BPA3.02338974
7CASK2.76981735
8TAOK32.69130856
9BUB12.54011089
10NME22.49505739
11IRAK42.33866730
12SRPK12.27107126
13VRK12.26900167
14NME12.23286789
15IRAK22.20516409
16PBK2.19907999
17ZAK2.18298943
18EIF2AK32.11054211
19NEK62.05815109
20MAP4K11.89289851
21PLK41.86093115
22TLK11.85821085
23BMPR1B1.84580616
24BCKDK1.83202134
25KIT1.80133903
26IRAK11.71283602
27INSRR1.65356599
28MUSK1.62163449
29DAPK21.61677358
30WEE11.60733691
31TIE11.50850936
32GRK61.50376516
33MARK11.48938685
34EIF2AK21.47319655
35TNIK1.43103519
36EIF2AK11.42390985
37VRK21.40070082
38ROCK21.37069877
39DYRK31.35880466
40CLK11.35480398
41ERN11.32416943
42BRD41.30612192
43DYRK21.28572173
44MKNK21.25766192
45GRK11.23083002
46ADRBK11.21408387
47STK391.19385283
48ADRBK21.18031528
49MAP2K61.17172631
50MKNK11.15345338
51TESK21.09659134
52OXSR11.09026023
53BMPR21.08194185
54TBK11.08175074
55MST41.06757374
56IKBKE1.06713413
57CDK191.05157442
58EPHA31.00710782
59MAPK150.99151170
60BCR0.97451463
61PIK3CA0.95286250
62SYK0.92566650
63MAP3K70.91201505
64PRKD20.90472864
65PHKG10.87625205
66PHKG20.87625205
67CDK80.86800564
68TTK0.86566666
69ITK0.84622839
70GRK70.84449146
71PNCK0.84062483
72PRKCQ0.83320195
73MAPKAPK50.83240903
74FES0.83108307
75MAPK130.78696332
76CAMK2B0.77868952
77CSNK1G10.76483932
78PLK10.74768883
79BRAF0.74698381
80ATR0.73729056
81PAK30.72795575
82AURKA0.72628967
83MAP3K40.72187613
84ACVR1B0.70881216
85CSF1R0.69930647
86PRKD30.69342573
87TXK0.68675657
88CSNK1G20.67374891
89ABL20.66277210
90PTK2B0.65252574
91YES10.64870211
92PKN10.63966275
93SIK20.63903823
94PIM20.63701073
95ARAF0.62990440
96IKBKB0.62721456
97RIPK40.62440435
98RPS6KB20.62135159
99BTK0.61861553
100CDK30.61424890
101UHMK10.60809300
102CSNK1G30.60598977
103CHUK0.60448789
104PLK30.60194742
105RPS6KA50.59468649
106TRIM280.59055682
107LCK0.58916225
108EPHA20.58600056
109BLK0.55677087
110BRSK20.55180932
111AKT30.54803068
112CAMK2D0.54735428
113CCNB10.53508145
114KDR0.53148577
115MARK30.51709750
116GRK50.51544949
117PINK10.51464976
118PRKCG0.51443327
119JAK30.51433333
120RPS6KA60.51124069
121CSNK2A20.50319958
122CSNK2A10.49854843
123DYRK1A0.49571215
124ROCK10.49365979
125LIMK10.49143001
126CAMK2G0.48127686
127CAMK10.48063325
128FER0.47984431
129MAP3K110.46743825
130WNK30.46640720
131TNK20.46466122
132CDK70.46462482
133TEC0.45808421
134CSNK1A10.45521027
135CDC70.45436321
136CAMKK20.43824877
137MAP2K70.43440213
138NTRK30.43347154
139PIK3CG0.43144349
140SGK4940.40733275
141SGK2230.40733275
142MAPKAPK30.40164009
143WNK40.39951191
144PRKCZ0.39092319
145PRKCI0.38729367
146STK110.38487901
147TYK20.38394982
148HCK0.38018570
149PRKACA0.37875352
150PRKCD0.37646531
151TGFBR10.37225440
152PRKAA20.36732097
153ABL10.36700023
154ZAP700.36354797
155PRPF4B0.34863394
156CSNK1A1L0.34497746
157CHEK20.33323404
158LYN0.31690265
159PRKCE0.30599739
160MAP2K20.30481175
161CAMK2A0.29787811

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.19796365
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.93765495
3RNA polymerase_Homo sapiens_hsa030203.79661458
4Oxidative phosphorylation_Homo sapiens_hsa001903.61804524
5Caffeine metabolism_Homo sapiens_hsa002323.51580044
6Parkinsons disease_Homo sapiens_hsa050123.18611172
7Proteasome_Homo sapiens_hsa030503.17828810
8Protein export_Homo sapiens_hsa030602.94052361
9DNA replication_Homo sapiens_hsa030302.92913598
10Pyrimidine metabolism_Homo sapiens_hsa002402.82102959
11Fanconi anemia pathway_Homo sapiens_hsa034602.71403925
12Huntingtons disease_Homo sapiens_hsa050162.64270749
13Mismatch repair_Homo sapiens_hsa034302.63365377
14Spliceosome_Homo sapiens_hsa030402.54487628
15Phototransduction_Homo sapiens_hsa047442.50584832
16Alzheimers disease_Homo sapiens_hsa050102.26734058
17Homologous recombination_Homo sapiens_hsa034402.20676139
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17805562
19Nucleotide excision repair_Homo sapiens_hsa034202.09202825
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.04702641
21Type I diabetes mellitus_Homo sapiens_hsa049401.95433900
22Nitrogen metabolism_Homo sapiens_hsa009101.92809553
23Basal transcription factors_Homo sapiens_hsa030221.89201489
24Purine metabolism_Homo sapiens_hsa002301.88259682
25Base excision repair_Homo sapiens_hsa034101.87406011
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.81218808
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77584844
28Butanoate metabolism_Homo sapiens_hsa006501.56005585
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53644442
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39580248
31RNA transport_Homo sapiens_hsa030131.38460404
32RNA degradation_Homo sapiens_hsa030181.34608548
33Tryptophan metabolism_Homo sapiens_hsa003801.32470338
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28233378
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24963533
36One carbon pool by folate_Homo sapiens_hsa006701.22270670
37Cardiac muscle contraction_Homo sapiens_hsa042601.14097939
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.10936075
39Selenocompound metabolism_Homo sapiens_hsa004501.09103132
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06163394
41Non-homologous end-joining_Homo sapiens_hsa034501.05856759
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.04959368
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04678575
44ABC transporters_Homo sapiens_hsa020101.02994075
45Fatty acid elongation_Homo sapiens_hsa000621.01534385
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99652858
47Arachidonic acid metabolism_Homo sapiens_hsa005900.97677485
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87451107
49Ether lipid metabolism_Homo sapiens_hsa005650.85890817
50Folate biosynthesis_Homo sapiens_hsa007900.83613683
51Propanoate metabolism_Homo sapiens_hsa006400.83463288
52Staphylococcus aureus infection_Homo sapiens_hsa051500.81875450
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.81319115
54Linoleic acid metabolism_Homo sapiens_hsa005910.81010635
55Glutathione metabolism_Homo sapiens_hsa004800.78297840
56Antigen processing and presentation_Homo sapiens_hsa046120.78043815
57Metabolic pathways_Homo sapiens_hsa011000.76096117
58Epstein-Barr virus infection_Homo sapiens_hsa051690.72847682
59Vitamin digestion and absorption_Homo sapiens_hsa049770.71285935
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69882700
61Retinol metabolism_Homo sapiens_hsa008300.69311920
62Nicotine addiction_Homo sapiens_hsa050330.69221920
63Cell cycle_Homo sapiens_hsa041100.68859989
64Ovarian steroidogenesis_Homo sapiens_hsa049130.68687136
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64553823
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64313754
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64124734
68Arginine and proline metabolism_Homo sapiens_hsa003300.64042127
69Fat digestion and absorption_Homo sapiens_hsa049750.63383967
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.62609226
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56622957
72Sphingolipid metabolism_Homo sapiens_hsa006000.56349769
73mRNA surveillance pathway_Homo sapiens_hsa030150.56128626
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.55670703
75Glycerolipid metabolism_Homo sapiens_hsa005610.55663617
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55339884
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53307597
78Vibrio cholerae infection_Homo sapiens_hsa051100.52141831
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51133324
80Autoimmune thyroid disease_Homo sapiens_hsa053200.51046386
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50907310
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.49175975
83Collecting duct acid secretion_Homo sapiens_hsa049660.49059654
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48283166
85Serotonergic synapse_Homo sapiens_hsa047260.46976371
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45828864
87p53 signaling pathway_Homo sapiens_hsa041150.45557052
88Fatty acid metabolism_Homo sapiens_hsa012120.43140123
89Leishmaniasis_Homo sapiens_hsa051400.42774634
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41348182
91Sulfur metabolism_Homo sapiens_hsa009200.39558148
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39408434
93Systemic lupus erythematosus_Homo sapiens_hsa053220.37797632
94Primary immunodeficiency_Homo sapiens_hsa053400.37603256
95Circadian entrainment_Homo sapiens_hsa047130.37440714
96Fatty acid degradation_Homo sapiens_hsa000710.37102500
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36772628
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33501451
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31665101
100Alcoholism_Homo sapiens_hsa050340.30516128
101Taste transduction_Homo sapiens_hsa047420.30374975
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30198517
103Tyrosine metabolism_Homo sapiens_hsa003500.29035587
104Morphine addiction_Homo sapiens_hsa050320.28021703
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27949874
106Other glycan degradation_Homo sapiens_hsa005110.27703155
107Sulfur relay system_Homo sapiens_hsa041220.26572439
108GABAergic synapse_Homo sapiens_hsa047270.23316797
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23056283
110Peroxisome_Homo sapiens_hsa041460.22943516
111Graft-versus-host disease_Homo sapiens_hsa053320.22185815
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.20997390
113Rheumatoid arthritis_Homo sapiens_hsa053230.20700728
114Axon guidance_Homo sapiens_hsa043600.20472175
115Regulation of autophagy_Homo sapiens_hsa041400.20359177
116Glutamatergic synapse_Homo sapiens_hsa047240.19605993
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19043078
118Histidine metabolism_Homo sapiens_hsa003400.18457301
119Cocaine addiction_Homo sapiens_hsa050300.18428942
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17184526
121Steroid biosynthesis_Homo sapiens_hsa001000.16566639
122Allograft rejection_Homo sapiens_hsa053300.16511691
123Amphetamine addiction_Homo sapiens_hsa050310.14859507
124Vitamin B6 metabolism_Homo sapiens_hsa007500.13997595
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.12952645
126beta-Alanine metabolism_Homo sapiens_hsa004100.12873272
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12566529
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.11267300
129Chemical carcinogenesis_Homo sapiens_hsa052040.09956729
130Olfactory transduction_Homo sapiens_hsa047400.09711684
131Hematopoietic cell lineage_Homo sapiens_hsa046400.08666719
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.08660246
133Asthma_Homo sapiens_hsa053100.08375468
134Herpes simplex infection_Homo sapiens_hsa051680.07829364

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