Rank | Gene Set | Z-score |
---|---|---|
1 | epoxygenase P450 pathway (GO:0019373) | 7.65241012 |
2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 6.55396837 |
3 | L-phenylalanine catabolic process (GO:0006559) | 6.55396837 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.40059845 |
5 | L-phenylalanine metabolic process (GO:0006558) | 6.40059845 |
6 | aromatic amino acid family catabolic process (GO:0009074) | 6.17777864 |
7 | indole-containing compound catabolic process (GO:0042436) | 5.96351587 |
8 | indolalkylamine catabolic process (GO:0046218) | 5.96351587 |
9 | tryptophan catabolic process (GO:0006569) | 5.96351587 |
10 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.90539306 |
11 | drug metabolic process (GO:0017144) | 5.89638358 |
12 | kynurenine metabolic process (GO:0070189) | 5.70011708 |
13 | glyoxylate metabolic process (GO:0046487) | 5.63283484 |
14 | tryptophan metabolic process (GO:0006568) | 5.59643025 |
15 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 5.54111292 |
16 | protein-lipid complex assembly (GO:0065005) | 5.41609342 |
17 | omega-hydroxylase P450 pathway (GO:0097267) | 5.22162877 |
18 | urea cycle (GO:0000050) | 5.21896837 |
19 | urea metabolic process (GO:0019627) | 5.21896837 |
20 | angiotensin maturation (GO:0002003) | 5.18764921 |
21 | high-density lipoprotein particle remodeling (GO:0034375) | 5.03746144 |
22 | bile acid biosynthetic process (GO:0006699) | 5.03333909 |
23 | serine family amino acid catabolic process (GO:0009071) | 5.02897096 |
24 | amino-acid betaine metabolic process (GO:0006577) | 4.99194151 |
25 | regulation of triglyceride catabolic process (GO:0010896) | 4.96520682 |
26 | cysteine metabolic process (GO:0006534) | 4.91423582 |
27 | fat-soluble vitamin biosynthetic process (GO:0042362) | 4.85968432 |
28 | lysine catabolic process (GO:0006554) | 4.83688410 |
29 | lysine metabolic process (GO:0006553) | 4.83688410 |
30 | sulfur amino acid catabolic process (GO:0000098) | 4.81969618 |
31 | alpha-linolenic acid metabolic process (GO:0036109) | 4.81779223 |
32 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 4.79197521 |
33 | nitrogen cycle metabolic process (GO:0071941) | 4.77624887 |
34 | intestinal absorption (GO:0050892) | 4.77192048 |
35 | plasma lipoprotein particle organization (GO:0071827) | 4.70393497 |
36 | regulation of cholesterol esterification (GO:0010872) | 4.68750052 |
37 | hormone catabolic process (GO:0042447) | 4.64262741 |
38 | NADH metabolic process (GO:0006734) | 4.62534973 |
39 | homocysteine metabolic process (GO:0050667) | 4.56672807 |
40 | aromatic amino acid family metabolic process (GO:0009072) | 4.56374421 |
41 | negative regulation of fibrinolysis (GO:0051918) | 4.53813151 |
42 | negative regulation of lipase activity (GO:0060192) | 4.49891146 |
43 | regulation of protein activation cascade (GO:2000257) | 4.45041155 |
44 | protein-lipid complex subunit organization (GO:0071825) | 4.44222464 |
45 | bile acid metabolic process (GO:0008206) | 4.43604086 |
46 | reverse cholesterol transport (GO:0043691) | 4.42783966 |
47 | peptidyl-glutamic acid carboxylation (GO:0017187) | 4.42103632 |
48 | protein carboxylation (GO:0018214) | 4.42103632 |
49 | alpha-amino acid catabolic process (GO:1901606) | 4.41350974 |
50 | plasma lipoprotein particle remodeling (GO:0034369) | 4.39175677 |
51 | protein-lipid complex remodeling (GO:0034368) | 4.39175677 |
52 | macromolecular complex remodeling (GO:0034367) | 4.39175677 |
53 | complement activation, alternative pathway (GO:0006957) | 4.38363533 |
54 | phospholipid efflux (GO:0033700) | 4.35688905 |
55 | regulation of fibrinolysis (GO:0051917) | 4.33915129 |
56 | alkaloid metabolic process (GO:0009820) | 4.32755027 |
57 | acylglycerol homeostasis (GO:0055090) | 4.31571097 |
58 | triglyceride homeostasis (GO:0070328) | 4.31571097 |
59 | drug catabolic process (GO:0042737) | 4.28901231 |
60 | lipoprotein transport (GO:0042953) | 4.27371484 |
61 | phenylpropanoid metabolic process (GO:0009698) | 4.25993326 |
62 | positive regulation of lipid catabolic process (GO:0050996) | 4.25048538 |
63 | indolalkylamine metabolic process (GO:0006586) | 4.24901816 |
64 | lipoprotein metabolic process (GO:0042157) | 4.20706398 |
65 | cellular biogenic amine catabolic process (GO:0042402) | 4.16623927 |
66 | amine catabolic process (GO:0009310) | 4.16623927 |
67 | regulation of complement activation (GO:0030449) | 4.11454691 |
68 | carnitine metabolic process (GO:0009437) | 4.10892304 |
69 | positive regulation of triglyceride lipase activity (GO:0061365) | 4.08177967 |
70 | positive regulation of lipoprotein lipase activity (GO:0051006) | 4.08177967 |
71 | cellular ketone body metabolic process (GO:0046950) | 4.07907352 |
72 | negative regulation of sterol transport (GO:0032372) | 4.07593762 |
73 | negative regulation of cholesterol transport (GO:0032375) | 4.07593762 |
74 | cellular glucuronidation (GO:0052695) | 4.07258642 |
75 | cellular amino acid catabolic process (GO:0009063) | 4.07031973 |
76 | tyrosine metabolic process (GO:0006570) | 4.05570564 |
77 | glycine metabolic process (GO:0006544) | 4.02676983 |
78 | drug transmembrane transport (GO:0006855) | 4.00885498 |
79 | diacylglycerol metabolic process (GO:0046339) | 3.97242306 |
80 | serine family amino acid metabolic process (GO:0009069) | 3.97096726 |
81 | plasma lipoprotein particle clearance (GO:0034381) | 3.92065354 |
82 | imidazole-containing compound metabolic process (GO:0052803) | 3.89660864 |
83 | coenzyme catabolic process (GO:0009109) | 3.89544799 |
84 | phospholipid homeostasis (GO:0055091) | 3.88821795 |
85 | fatty acid beta-oxidation (GO:0006635) | 3.88763634 |
86 | cellular modified amino acid catabolic process (GO:0042219) | 3.87965027 |
87 | bile acid and bile salt transport (GO:0015721) | 3.87456438 |
88 | ethanol metabolic process (GO:0006067) | 3.86568259 |
89 | aspartate family amino acid catabolic process (GO:0009068) | 3.85931268 |
90 | benzene-containing compound metabolic process (GO:0042537) | 3.85233239 |
91 | fibrinolysis (GO:0042730) | 3.84551257 |
92 | proline metabolic process (GO:0006560) | 3.83776488 |
93 | regulation of bile acid biosynthetic process (GO:0070857) | 3.82750185 |
94 | fructose metabolic process (GO:0006000) | 3.82496801 |
95 | organic cation transport (GO:0015695) | 3.80013382 |
96 | oxidative demethylation (GO:0070989) | 3.79465498 |
97 | cholesterol efflux (GO:0033344) | 3.76985257 |
98 | arginine metabolic process (GO:0006525) | 3.76720888 |
99 | glutamate metabolic process (GO:0006536) | 3.76704449 |
100 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 3.76667365 |
101 | exogenous drug catabolic process (GO:0042738) | 3.76650139 |
102 | organic acid catabolic process (GO:0016054) | 3.74354655 |
103 | carboxylic acid catabolic process (GO:0046395) | 3.74354655 |
104 | urate metabolic process (GO:0046415) | 3.72643446 |
105 | NAD biosynthetic process (GO:0009435) | 3.72433065 |
106 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.70321897 |
107 | serine family amino acid biosynthetic process (GO:0009070) | 3.69339909 |
108 | fatty acid oxidation (GO:0019395) | 3.67475393 |
109 | 2-oxoglutarate metabolic process (GO:0006103) | 3.64378044 |
110 | fatty acid catabolic process (GO:0009062) | 3.63604508 |
111 | complement activation, classical pathway (GO:0006958) | 3.63559139 |
112 | flavonoid metabolic process (GO:0009812) | 3.63507747 |
113 | plasma lipoprotein particle assembly (GO:0034377) | 3.62133749 |
114 | monocarboxylic acid catabolic process (GO:0072329) | 3.61965302 |
115 | lipid oxidation (GO:0034440) | 3.61415627 |
116 | cholesterol homeostasis (GO:0042632) | 3.60518356 |
117 | glutamine family amino acid biosynthetic process (GO:0009084) | 3.59868621 |
118 | negative regulation of blood coagulation (GO:0030195) | 3.59085925 |
119 | negative regulation of hemostasis (GO:1900047) | 3.59085925 |
120 | short-chain fatty acid metabolic process (GO:0046459) | 3.57798178 |
121 | glucuronate metabolic process (GO:0019585) | 3.57266313 |
122 | uronic acid metabolic process (GO:0006063) | 3.57266313 |
123 | low-density lipoprotein particle remodeling (GO:0034374) | 3.57144406 |
124 | pyridine nucleotide biosynthetic process (GO:0019363) | 3.55086569 |
125 | nicotinamide nucleotide biosynthetic process (GO:0019359) | 3.55086569 |
126 | sterol homeostasis (GO:0055092) | 3.54326639 |
127 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.53998928 |
128 | protein activation cascade (GO:0072376) | 3.53316375 |
129 | ethanol oxidation (GO:0006069) | 3.52310619 |
130 | blood coagulation, intrinsic pathway (GO:0007597) | 3.48395556 |
131 | regulation of guanylate cyclase activity (GO:0031282) | 3.44974051 |
132 | intestinal cholesterol absorption (GO:0030299) | 3.44635826 |
133 | complement activation (GO:0006956) | 3.43771177 |
134 | heme transport (GO:0015886) | 3.40910250 |
135 | regulation of lipoprotein particle clearance (GO:0010984) | 3.40039868 |
136 | regulation of sterol transport (GO:0032371) | 3.37284044 |
137 | regulation of cholesterol transport (GO:0032374) | 3.37284044 |
138 | L-ascorbic acid metabolic process (GO:0019852) | 3.36887061 |
139 | drug transport (GO:0015893) | 3.33356171 |
140 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.32469955 |
141 | negative regulation of coagulation (GO:0050819) | 3.30903380 |
142 | regulation of plasminogen activation (GO:0010755) | 3.29882087 |
143 | positive regulation of triglyceride metabolic process (GO:0090208) | 3.29388119 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 7.45456892 |
2 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 6.63757866 |
3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 6.45993459 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 5.91413812 |
5 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.11782251 |
6 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 4.71510230 |
7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.47235986 |
8 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.69327984 |
9 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.59766802 |
10 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.05455544 |
11 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 10.4251887 |
12 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.96833600 |
13 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.89416929 |
14 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.86607153 |
15 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.86508620 |
16 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.86106963 |
17 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.83108794 |
18 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.78876783 |
19 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.70251000 |
20 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.64534914 |
21 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.55539505 |
22 | * RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.54219551 |
23 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.53585267 |
24 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.53243319 |
25 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.51992707 |
26 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.46596676 |
27 | GATA1_22025678_ChIP-Seq_K562_Human | 1.46200753 |
28 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.45115075 |
29 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.41978299 |
30 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.41227150 |
31 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.34519850 |
32 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.31792632 |
33 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.30066407 |
34 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.27920786 |
35 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.22647911 |
36 | * SA1_27219007_Chip-Seq_Bcells_Human | 1.21839542 |
37 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.17093446 |
38 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.15989965 |
39 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.13934026 |
40 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.13470625 |
41 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.13162903 |
42 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.08502523 |
43 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.08101913 |
44 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.06904884 |
45 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 1.06032412 |
46 | STAT1_17558387_ChIP-Seq_HELA_Human | 1.05175112 |
47 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.04602356 |
48 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.03100585 |
49 | * JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 1.02064797 |
50 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.01792629 |
51 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.99115472 |
52 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.98088910 |
53 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.97081669 |
54 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.95853963 |
55 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.94292752 |
56 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.94244374 |
57 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.93912681 |
58 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.93054361 |
59 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.91759087 |
60 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.91412207 |
61 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.91212453 |
62 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.89670340 |
63 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.88550477 |
64 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.88489258 |
65 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.88341634 |
66 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.88203292 |
67 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.87472756 |
68 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.87407202 |
69 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.87142894 |
70 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.85683603 |
71 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.85474497 |
72 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 0.84948240 |
73 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.84289380 |
74 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.83478741 |
75 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.83313419 |
76 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.82806100 |
77 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.82668672 |
78 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.82585459 |
79 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.82232612 |
80 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.82079801 |
81 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.81835489 |
82 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.81698604 |
83 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.81050519 |
84 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 0.80168300 |
85 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.78883110 |
86 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.78586620 |
87 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.77850339 |
88 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.77119823 |
89 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.76566042 |
90 | AR_20517297_ChIP-Seq_VCAP_Human | 0.76461169 |
91 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.76408534 |
92 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.75718891 |
93 | SPI1_26923725_Chip-Seq_HPCs_Mouse | 0.73515070 |
94 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.73398416 |
95 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.72632502 |
96 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.71257562 |
97 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.70899947 |
98 | P68_20966046_ChIP-Seq_HELA_Human | 0.70793759 |
99 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.70664517 |
100 | SETDB1_19884257_ChIP-Seq_MESCs_Mouse | 0.70546625 |
101 | P300_27268052_Chip-Seq_Bcells_Human | 0.69517531 |
102 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.69437437 |
103 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.69367429 |
104 | * CEBPB_22108803_ChIP-Seq_LS180_Human | 0.69083722 |
105 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.68456058 |
106 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.67752312 |
107 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.67481171 |
108 | * CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.67365143 |
109 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.67252042 |
110 | * HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.66892910 |
111 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.66878385 |
112 | * ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.66491479 |
113 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.66169855 |
114 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.66108842 |
115 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 0.65602207 |
116 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.65387150 |
117 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.64622320 |
118 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.64147878 |
119 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.63450618 |
120 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.63326929 |
121 | VDR_22108803_ChIP-Seq_LS180_Human | 0.63324610 |
122 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.62491908 |
123 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.62401745 |
124 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.62034874 |
125 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.61912166 |
126 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.61912166 |
127 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.60916077 |
128 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.60776341 |
129 | LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.60122044 |
130 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.59571691 |
131 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.59424388 |
132 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.59115467 |
133 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.59091283 |
134 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.58816516 |
135 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.58725987 |
136 | FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.58717943 |
137 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.58595360 |
138 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.57618725 |
139 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.57172243 |
140 | SOX11_22085726_ChIP-Seq_ESNs_Mouse | 0.56557930 |
141 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.56301077 |
142 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.56202209 |
143 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.55526990 |
144 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 0.55504906 |
145 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.55362867 |
146 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.55262940 |
147 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.55262066 |
148 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.54787265 |
149 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.54730942 |
150 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.54635319 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 7.58762423 |
2 | MP0005360_urolithiasis | 7.43373594 |
3 | MP0005085_abnormal_gallbladder_physiolo | 5.92152346 |
4 | MP0005365_abnormal_bile_salt | 5.66590904 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.66122527 |
6 | MP0003806_abnormal_nucleotide_metabolis | 4.27433072 |
7 | MP0003252_abnormal_bile_duct | 3.51501910 |
8 | MP0009840_abnormal_foam_cell | 3.27621193 |
9 | MP0010329_abnormal_lipoprotein_level | 3.22968845 |
10 | MP0005332_abnormal_amino_acid | 2.91105384 |
11 | MP0003195_calcinosis | 2.77834159 |
12 | MP0004019_abnormal_vitamin_homeostasis | 2.60615530 |
13 | MP0005410_abnormal_fertilization | 2.58778840 |
14 | MP0001666_abnormal_nutrient_absorption | 2.54784559 |
15 | MP0005083_abnormal_biliary_tract | 2.45881947 |
16 | MP0003191_abnormal_cellular_cholesterol | 2.15921994 |
17 | MP0005670_abnormal_white_adipose | 2.04085823 |
18 | MP0001764_abnormal_homeostasis | 1.97900717 |
19 | MP0005319_abnormal_enzyme/_coenzyme | 1.96420822 |
20 | MP0003183_abnormal_peptide_metabolism | 1.94405011 |
21 | MP0002118_abnormal_lipid_homeostasis | 1.91753036 |
22 | MP0000609_abnormal_liver_physiology | 1.90577336 |
23 | MP0002138_abnormal_hepatobiliary_system | 1.83195689 |
24 | MP0005451_abnormal_body_composition | 1.74057744 |
25 | MP0002837_dystrophic_cardiac_calcinosis | 1.70941685 |
26 | MP0003646_muscle_fatigue | 1.65576160 |
27 | MP0009379_abnormal_foot_pigmentation | 1.63598863 |
28 | MP0009697_abnormal_copulation | 1.51400188 |
29 | MP0010155_abnormal_intestine_physiology | 1.48019863 |
30 | MP0009643_abnormal_urine_homeostasis | 1.47964214 |
31 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.46775507 |
32 | MP0003186_abnormal_redox_activity | 1.45394810 |
33 | MP0003011_delayed_dark_adaptation | 1.40393779 |
34 | MP0003868_abnormal_feces_composition | 1.28921995 |
35 | MP0006036_abnormal_mitochondrial_physio | 1.25344678 |
36 | MP0003879_abnormal_hair_cell | 1.22482319 |
37 | MP0005647_abnormal_sex_gland | 1.20910179 |
38 | MP0005636_abnormal_mineral_homeostasis | 1.19646539 |
39 | MP0009764_decreased_sensitivity_to | 1.15125817 |
40 | MP0010234_abnormal_vibrissa_follicle | 1.10378566 |
41 | MP0000598_abnormal_liver_morphology | 1.06303696 |
42 | MP0005409_darkened_coat_color | 1.06200526 |
43 | MP0003656_abnormal_erythrocyte_physiolo | 1.05286295 |
44 | MP0002876_abnormal_thyroid_physiology | 1.04375755 |
45 | MP0005084_abnormal_gallbladder_morpholo | 0.97001932 |
46 | MP0005166_decreased_susceptibility_to | 0.95187391 |
47 | MP0009763_increased_sensitivity_to | 0.93603202 |
48 | MP0008469_abnormal_protein_level | 0.91203674 |
49 | MP0009642_abnormal_blood_homeostasis | 0.90646160 |
50 | MP0001664_abnormal_digestion | 0.86633129 |
51 | MP0003866_abnormal_defecation | 0.84166429 |
52 | MP0006035_abnormal_mitochondrial_morpho | 0.83561550 |
53 | MP0005376_homeostasis/metabolism_phenot | 0.83221529 |
54 | MP0005266_abnormal_metabolism | 0.82490683 |
55 | MP0001756_abnormal_urination | 0.80065953 |
56 | MP0005058_abnormal_lysosome_morphology | 0.78394434 |
57 | MP0010368_abnormal_lymphatic_system | 0.76516027 |
58 | MP0004130_abnormal_muscle_cell | 0.76145628 |
59 | MP0003698_abnormal_male_reproductive | 0.74196408 |
60 | MP0002078_abnormal_glucose_homeostasis | 0.72382477 |
61 | MP0005330_cardiomyopathy | 0.72279792 |
62 | MP0005666_abnormal_adipose_tissue | 0.71615767 |
63 | MP0002136_abnormal_kidney_physiology | 0.71413690 |
64 | MP0000477_abnormal_intestine_morphology | 0.70678141 |
65 | MP0005334_abnormal_fat_pad | 0.69646514 |
66 | MP0001929_abnormal_gametogenesis | 0.69458484 |
67 | MP0002971_abnormal_brown_adipose | 0.68638845 |
68 | MP0004043_abnormal_pH_regulation | 0.68376202 |
69 | MP0009765_abnormal_xenobiotic_induced | 0.67590879 |
70 | MP0000678_abnormal_parathyroid_gland | 0.67075670 |
71 | MP0001663_abnormal_digestive_system | 0.66601998 |
72 | MP0002822_catalepsy | 0.66352015 |
73 | MP0001765_abnormal_ion_homeostasis | 0.65514970 |
74 | MP0004858_abnormal_nervous_system | 0.63602582 |
75 | MP0000490_abnormal_crypts_of | 0.63046406 |
76 | MP0003718_maternal_effect | 0.62992411 |
77 | MP0000249_abnormal_blood_vessel | 0.62873884 |
78 | MP0008872_abnormal_physiological_respon | 0.62188210 |
79 | MP0004782_abnormal_surfactant_physiolog | 0.62089149 |
80 | MP0005535_abnormal_body_temperature | 0.60084630 |
81 | MP0002269_muscular_atrophy | 0.58885232 |
82 | MP0002254_reproductive_system_inflammat | 0.58653265 |
83 | MP0000604_amyloidosis | 0.57899635 |
84 | MP0005408_hypopigmentation | 0.57744378 |
85 | MP0004270_analgesia | 0.57741832 |
86 | MP0001845_abnormal_inflammatory_respons | 0.56459048 |
87 | MP0004215_abnormal_myocardial_fiber | 0.55560271 |
88 | MP0010352_gastrointestinal_tract_polyps | 0.55551356 |
89 | MP0009115_abnormal_fat_cell | 0.55062670 |
90 | MP0003705_abnormal_hypodermis_morpholog | 0.54618442 |
91 | MP0005395_other_phenotype | 0.54171196 |
92 | MP0005381_digestive/alimentary_phenotyp | 0.52824097 |
93 | MP0004264_abnormal_extraembryonic_tissu | 0.52109247 |
94 | MP0003329_amyloid_beta_deposits | 0.51691978 |
95 | MP0000462_abnormal_digestive_system | 0.51642547 |
96 | MP0009785_altered_susceptibility_to | 0.49690201 |
97 | MP0002132_abnormal_respiratory_system | 0.48981319 |
98 | MP0005448_abnormal_energy_balance | 0.47019436 |
99 | MP0002161_abnormal_fertility/fecundity | 0.45700637 |
100 | MP0003953_abnormal_hormone_level | 0.45424811 |
101 | MP0005385_cardiovascular_system_phenoty | 0.44299997 |
102 | MP0001544_abnormal_cardiovascular_syste | 0.44299997 |
103 | MP0000566_synostosis | 0.44123217 |
104 | MP0004084_abnormal_cardiac_muscle | 0.44014118 |
105 | MP0000230_abnormal_systemic_arterial | 0.42897514 |
106 | MP0001661_extended_life_span | 0.42799742 |
107 | MP0004147_increased_porphyrin_level | 0.41883009 |
108 | MP0004036_abnormal_muscle_relaxation | 0.41721952 |
109 | MP0001873_stomach_inflammation | 0.41352661 |
110 | MP0000538_abnormal_urinary_bladder | 0.39626015 |
111 | MP0002928_abnormal_bile_duct | 0.39589343 |
112 | MP0002796_impaired_skin_barrier | 0.38810093 |
113 | MP0006138_congestive_heart_failure | 0.38808068 |
114 | MP0000579_abnormal_nail_morphology | 0.36682384 |
115 | MP0003638_abnormal_response/metabolism_ | 0.35575977 |
116 | MP0005464_abnormal_platelet_physiology | 0.35575177 |
117 | MP0001188_hyperpigmentation | 0.35565288 |
118 | MP0005023_abnormal_wound_healing | 0.35380692 |
119 | MP0009672_abnormal_birth_weight | 0.34724579 |
120 | MP0008873_increased_physiological_sensi | 0.34551058 |
121 | MP0003075_altered_response_to | 0.33709545 |
122 | MP0003436_decreased_susceptibility_to | 0.33218011 |
123 | MP0001881_abnormal_mammary_gland | 0.33094742 |
124 | MP0001853_heart_inflammation | 0.32876971 |
125 | MP0002089_abnormal_postnatal_growth/wei | 0.32708207 |
126 | MP0010630_abnormal_cardiac_muscle | 0.31888738 |
127 | MP0002127_abnormal_cardiovascular_syste | 0.31505479 |
128 | MP0009053_abnormal_anal_canal | 0.31084102 |
129 | MP0002168_other_aberrant_phenotype | 0.30924768 |
130 | MP0005075_abnormal_melanosome_morpholog | 0.30910645 |
131 | MP0002098_abnormal_vibrissa_morphology | 0.30891502 |
132 | MP0002972_abnormal_cardiac_muscle | 0.30879280 |
133 | MP0005025_abnormal_response_to | 0.30822273 |
134 | MP0001501_abnormal_sleep_pattern | 0.30380632 |
135 | MP0001986_abnormal_taste_sensitivity | 0.30308995 |
136 | MP0004381_abnormal_hair_follicle | 0.29585879 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Intrahepatic cholestasis (HP:0001406) | 6.09654531 |
2 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 5.98325262 |
3 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 5.56713173 |
4 | Deep venous thrombosis (HP:0002625) | 5.56528325 |
5 | Hypobetalipoproteinemia (HP:0003563) | 5.41829956 |
6 | Xanthomatosis (HP:0000991) | 5.27984731 |
7 | Prolonged partial thromboplastin time (HP:0003645) | 5.22483046 |
8 | Hyperlipoproteinemia (HP:0010980) | 4.68984163 |
9 | Hyperglycinuria (HP:0003108) | 4.64770345 |
10 | Hyperammonemia (HP:0001987) | 4.63123725 |
11 | Hypolipoproteinemia (HP:0010981) | 4.31593970 |
12 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.29644483 |
13 | Hyperglycinemia (HP:0002154) | 4.29437186 |
14 | Ketosis (HP:0001946) | 4.24031246 |
15 | Abnormality of glycine metabolism (HP:0010895) | 4.17902565 |
16 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.17902565 |
17 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.12393300 |
18 | Joint hemorrhage (HP:0005261) | 4.10915038 |
19 | Complement deficiency (HP:0004431) | 4.06825373 |
20 | Hypoglycemic coma (HP:0001325) | 4.01530658 |
21 | Hypoalphalipoproteinemia (HP:0003233) | 3.97607919 |
22 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 3.96885666 |
23 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.96599738 |
24 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.84692670 |
25 | Abnormality of methionine metabolism (HP:0010901) | 3.83927714 |
26 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.71656264 |
27 | Epidermoid cyst (HP:0200040) | 3.70979426 |
28 | Fat malabsorption (HP:0002630) | 3.57527455 |
29 | Conjugated hyperbilirubinemia (HP:0002908) | 3.51646436 |
30 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.50674575 |
31 | Hypercholesterolemia (HP:0003124) | 3.34368927 |
32 | Dicarboxylic aciduria (HP:0003215) | 3.33252448 |
33 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.33252448 |
34 | Abnormality of the common coagulation pathway (HP:0010990) | 3.24926318 |
35 | Abnormality of nucleobase metabolism (HP:0010932) | 3.23435872 |
36 | Abnormality of serum amino acid levels (HP:0003112) | 3.19023179 |
37 | Ketoacidosis (HP:0001993) | 3.17080301 |
38 | Metabolic acidosis (HP:0001942) | 3.12396722 |
39 | Vascular calcification (HP:0004934) | 3.12291657 |
40 | Nephritis (HP:0000123) | 3.06807336 |
41 | Proximal tubulopathy (HP:0000114) | 3.02481903 |
42 | Hyperbilirubinemia (HP:0002904) | 3.01219315 |
43 | Widely patent fontanelles and sutures (HP:0004492) | 3.00868095 |
44 | Abnormality of the intrinsic pathway (HP:0010989) | 3.00292040 |
45 | Abnormality of purine metabolism (HP:0004352) | 2.99325676 |
46 | Abnormality of complement system (HP:0005339) | 2.99086041 |
47 | Lethargy (HP:0001254) | 2.94923589 |
48 | Gout (HP:0001997) | 2.93360640 |
49 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.90264573 |
50 | Generalized aminoaciduria (HP:0002909) | 2.87952948 |
51 | Confusion (HP:0001289) | 2.77574056 |
52 | Abnormality of vitamin B metabolism (HP:0004340) | 2.76369953 |
53 | Cardiovascular calcification (HP:0011915) | 2.69306722 |
54 | Amyloidosis (HP:0011034) | 2.68771850 |
55 | Ileus (HP:0002595) | 2.66821169 |
56 | Cerebral edema (HP:0002181) | 2.66616249 |
57 | Renal cortical cysts (HP:0000803) | 2.55927498 |
58 | Malnutrition (HP:0004395) | 2.55367456 |
59 | Spontaneous abortion (HP:0005268) | 2.54188952 |
60 | Hyperphosphaturia (HP:0003109) | 2.54148411 |
61 | Steatorrhea (HP:0002570) | 2.53002336 |
62 | Delayed CNS myelination (HP:0002188) | 2.51159949 |
63 | Nephrolithiasis (HP:0000787) | 2.50227238 |
64 | Myocardial infarction (HP:0001658) | 2.49566743 |
65 | Pigmentary retinal degeneration (HP:0001146) | 2.47324015 |
66 | Hepatocellular carcinoma (HP:0001402) | 2.39541186 |
67 | Nausea (HP:0002018) | 2.38366296 |
68 | Abnormal urine phosphate concentration (HP:0012599) | 2.38027998 |
69 | Vomiting (HP:0002013) | 2.36375057 |
70 | Hypoglycemic seizures (HP:0002173) | 2.36359788 |
71 | Hypophosphatemia (HP:0002148) | 2.33022896 |
72 | Megaloblastic anemia (HP:0001889) | 2.31042342 |
73 | Abnormal gallbladder physiology (HP:0012438) | 2.29696751 |
74 | Cholecystitis (HP:0001082) | 2.29696751 |
75 | Facial shape deformation (HP:0011334) | 2.29369429 |
76 | Potter facies (HP:0002009) | 2.29369429 |
77 | Glycosuria (HP:0003076) | 2.26762943 |
78 | Abnormality of urine glucose concentration (HP:0011016) | 2.26762943 |
79 | Systemic lupus erythematosus (HP:0002725) | 2.26637914 |
80 | Hyperuricemia (HP:0002149) | 2.26577306 |
81 | Increased purine levels (HP:0004368) | 2.26577306 |
82 | Chronic diarrhea (HP:0002028) | 2.26492208 |
83 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.25464183 |
84 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.24065163 |
85 | Abnormal enzyme/coenzyme activity (HP:0012379) | 2.21984636 |
86 | Abnormality of alkaline phosphatase activity (HP:0004379) | 2.20791883 |
87 | Absent/shortened dynein arms (HP:0200106) | 2.18732108 |
88 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.18732108 |
89 | Pancreatitis (HP:0001733) | 2.18538114 |
90 | Cholelithiasis (HP:0001081) | 2.18285156 |
91 | Abnormality of proline metabolism (HP:0010907) | 2.17298975 |
92 | Hydroxyprolinuria (HP:0003080) | 2.17298975 |
93 | Hypochromic microcytic anemia (HP:0004840) | 2.17018645 |
94 | Skin nodule (HP:0200036) | 2.16669997 |
95 | Wide cranial sutures (HP:0010537) | 2.15723793 |
96 | Abnormal gallbladder morphology (HP:0012437) | 2.13412376 |
97 | Late onset (HP:0003584) | 2.13145442 |
98 | Myoglobinuria (HP:0002913) | 2.12461428 |
99 | Cerebral palsy (HP:0100021) | 2.11674424 |
100 | Elevated alkaline phosphatase (HP:0003155) | 2.11533104 |
101 | Enlarged kidneys (HP:0000105) | 2.11073564 |
102 | Opisthotonus (HP:0002179) | 2.06997558 |
103 | Irritability (HP:0000737) | 2.04698653 |
104 | Abnormal biliary tract physiology (HP:0012439) | 2.02081067 |
105 | Bile duct proliferation (HP:0001408) | 2.02081067 |
106 | Alkalosis (HP:0001948) | 1.97153473 |
107 | Hemorrhage of the eye (HP:0011885) | 1.95757604 |
108 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.94948736 |
109 | Acanthocytosis (HP:0001927) | 1.94627740 |
110 | Thrombophlebitis (HP:0004418) | 1.94428443 |
111 | Elevated hepatic transaminases (HP:0002910) | 1.91886279 |
112 | Poikilocytosis (HP:0004447) | 1.87915548 |
113 | Rickets (HP:0002748) | 1.87089060 |
114 | Abdominal distention (HP:0003270) | 1.86629295 |
115 | Neonatal onset (HP:0003623) | 1.86535964 |
116 | Abnormality of vitamin metabolism (HP:0100508) | 1.86470498 |
117 | Osteomalacia (HP:0002749) | 1.86469388 |
118 | Sensorimotor neuropathy (HP:0007141) | 1.86233708 |
119 | Rhabdomyolysis (HP:0003201) | 1.85840795 |
120 | Glomerulonephritis (HP:0000099) | 1.81040641 |
121 | Hepatic necrosis (HP:0002605) | 1.80817163 |
122 | Gingival bleeding (HP:0000225) | 1.80609970 |
123 | Abnormality of the gallbladder (HP:0005264) | 1.80212062 |
124 | Hypotension (HP:0002615) | 1.78693184 |
125 | Metabolic alkalosis (HP:0200114) | 1.70804308 |
126 | Menorrhagia (HP:0000132) | 1.70590575 |
127 | Reduced antithrombin III activity (HP:0001976) | 1.70181822 |
128 | Joint swelling (HP:0001386) | 1.68894230 |
129 | Abnormal tarsal ossification (HP:0008369) | 1.67194499 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 6.79342441 |
2 | ACVR1B | 6.07071131 |
3 | PDK4 | 4.33061270 |
4 | PDK3 | 4.33061270 |
5 | RIPK1 | 3.54560604 |
6 | TESK2 | 3.04141028 |
7 | STK38L | 2.94651180 |
8 | PDK2 | 2.71564479 |
9 | FGFR4 | 2.60913732 |
10 | INSRR | 2.60247753 |
11 | SIK1 | 2.33376201 |
12 | PINK1 | 2.27067202 |
13 | ERN1 | 2.18709834 |
14 | ICK | 1.95985438 |
15 | IRAK3 | 1.86921820 |
16 | MAP3K12 | 1.81065176 |
17 | ZAK | 1.73521028 |
18 | ERBB4 | 1.73129825 |
19 | TAOK3 | 1.70318862 |
20 | EPHA2 | 1.69929864 |
21 | TIE1 | 1.59341504 |
22 | MYLK | 1.59196051 |
23 | AKT3 | 1.57584934 |
24 | MET | 1.48624713 |
25 | MST1R | 1.48472731 |
26 | TESK1 | 1.41986652 |
27 | WNK4 | 1.39863892 |
28 | MAPK11 | 1.35720806 |
29 | MAP3K10 | 1.29192184 |
30 | MAP3K2 | 1.27113567 |
31 | STK38 | 1.26783461 |
32 | LMTK2 | 1.22383451 |
33 | EPHB2 | 1.21988836 |
34 | EPHA4 | 1.16452848 |
35 | MAP2K6 | 1.13505158 |
36 | LATS1 | 1.11543582 |
37 | PKN2 | 1.11448292 |
38 | MAP4K1 | 1.11165737 |
39 | TYK2 | 1.10620547 |
40 | SGK2 | 1.08892248 |
41 | MAP3K1 | 1.06496926 |
42 | FLT3 | 1.05166846 |
43 | MAP3K14 | 1.04514443 |
44 | EPHA3 | 1.04130330 |
45 | TNIK | 1.03503656 |
46 | CDK19 | 1.03201434 |
47 | MAP2K2 | 1.02611364 |
48 | OXSR1 | 1.01139943 |
49 | OBSCN | 0.98580010 |
50 | SGK3 | 0.97621987 |
51 | PRKAA2 | 0.97346782 |
52 | MAP3K3 | 0.95704254 |
53 | EPHB1 | 0.93420529 |
54 | MATK | 0.93080076 |
55 | DYRK1B | 0.92520942 |
56 | TRIB3 | 0.92268440 |
57 | PRKAA1 | 0.92004632 |
58 | PRPF4B | 0.91263981 |
59 | DDR2 | 0.89172270 |
60 | FGFR3 | 0.88347005 |
61 | PRKD3 | 0.87483310 |
62 | PIK3CG | 0.87358146 |
63 | TTK | 0.85647138 |
64 | FRK | 0.85362106 |
65 | TBK1 | 0.82295688 |
66 | TAOK2 | 0.79039448 |
67 | GRK1 | 0.78536909 |
68 | MAP2K3 | 0.78223285 |
69 | MAP2K4 | 0.77923739 |
70 | STK16 | 0.77399954 |
71 | NEK9 | 0.76695284 |
72 | STK4 | 0.76551563 |
73 | NLK | 0.74917529 |
74 | STK24 | 0.74885556 |
75 | MAPK15 | 0.70544531 |
76 | KSR2 | 0.69821841 |
77 | MUSK | 0.69533699 |
78 | TTN | 0.67132901 |
79 | GRK6 | 0.66963246 |
80 | PBK | 0.66880797 |
81 | PRKCA | 0.66814100 |
82 | ABL2 | 0.66622947 |
83 | STK39 | 0.64573552 |
84 | MAPK4 | 0.64030932 |
85 | PTK6 | 0.63187343 |
86 | KDR | 0.62617974 |
87 | CDK4 | 0.61412183 |
88 | PIK3CA | 0.61174823 |
89 | PRKCZ | 0.60348501 |
90 | NUAK1 | 0.59808678 |
91 | FER | 0.59111836 |
92 | MAP3K5 | 0.58753275 |
93 | PRKACG | 0.56492420 |
94 | CAMK2G | 0.55768632 |
95 | CDC42BPA | 0.55476069 |
96 | SGK494 | 0.55283765 |
97 | SGK223 | 0.55283765 |
98 | PHKG1 | 0.53065278 |
99 | PHKG2 | 0.53065278 |
100 | PDPK1 | 0.51292370 |
101 | PIM2 | 0.49637901 |
102 | SRC | 0.48807268 |
103 | PAK4 | 0.48485145 |
104 | PTK2 | 0.48138680 |
105 | PDK1 | 0.47130813 |
106 | MAP3K11 | 0.46798264 |
107 | CSF1R | 0.46642325 |
108 | EIF2AK2 | 0.45505492 |
109 | IGF1R | 0.44955558 |
110 | STK3 | 0.44689230 |
111 | JAK1 | 0.44560085 |
112 | TAOK1 | 0.44436155 |
113 | IKBKE | 0.42570940 |
114 | PDGFRA | 0.42467064 |
115 | CHUK | 0.41835326 |
116 | MAPK12 | 0.41814550 |
117 | CASK | 0.41538305 |
118 | GRK7 | 0.41439883 |
119 | BMX | 0.41429053 |
120 | NEK1 | 0.41213465 |
121 | CAMK4 | 0.40345640 |
122 | IRAK1 | 0.40274885 |
123 | PIM1 | 0.40194610 |
124 | MAPK7 | 0.39916262 |
125 | PLK4 | 0.39635695 |
126 | GSK3A | 0.38668381 |
127 | PRKACA | 0.38194315 |
128 | MST4 | 0.36764501 |
129 | CAMK2D | 0.36538706 |
130 | MAP3K7 | 0.36527045 |
131 | PRKCD | 0.36203024 |
132 | CDK6 | 0.34768753 |
133 | JAK2 | 0.34758548 |
134 | RPS6KL1 | 0.34700933 |
135 | RPS6KC1 | 0.34700933 |
136 | IRAK4 | 0.33870261 |
137 | RIPK4 | 0.33422946 |
138 | SMG1 | 0.33026206 |
139 | RPS6KA6 | 0.32492089 |
140 | PKN1 | 0.32151727 |
141 | ERBB2 | 0.31785615 |
142 | PRKG2 | 0.31528227 |
143 | ZAP70 | 0.31389056 |
144 | PRKG1 | 0.30100932 |
145 | PRKCI | 0.28632693 |
146 | PRKCB | 0.25432835 |
147 | CSNK1A1 | 0.25286311 |
148 | RET | 0.24073758 |
149 | FYN | 0.21318009 |
150 | LRRK2 | 0.20285360 |
151 | MAP3K8 | 0.20230771 |
152 | WNK3 | 0.20160940 |
153 | PRKCQ | 0.19533877 |
154 | DAPK3 | 0.19146756 |
155 | PRKCG | 0.18686668 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.73309445 |
2 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.30238929 |
3 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.10362675 |
4 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.80791435 |
5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.65692930 |
6 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.64443065 |
7 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.63137947 |
8 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.42969032 |
9 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.41482065 |
10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.40974150 |
11 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.38951192 |
12 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.34981519 |
13 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.28614021 |
14 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.18579194 |
15 | Peroxisome_Homo sapiens_hsa04146 | 2.18229141 |
16 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.09421098 |
17 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.04376619 |
18 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.02943147 |
19 | PPAR signaling pathway_Homo sapiens_hsa03320 | 2.01820145 |
20 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.98419201 |
21 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.83427532 |
22 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.80808587 |
23 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.80511085 |
24 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.76837151 |
25 | Histidine metabolism_Homo sapiens_hsa00340 | 1.75854072 |
26 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.74558777 |
27 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.73047790 |
28 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.72027781 |
29 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.66200403 |
30 | Retinol metabolism_Homo sapiens_hsa00830 | 1.65680511 |
31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.53138047 |
32 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.52877945 |
33 | Carbon metabolism_Homo sapiens_hsa01200 | 1.52652896 |
34 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.45692092 |
35 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.45161982 |
36 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.44639287 |
37 | Bile secretion_Homo sapiens_hsa04976 | 1.42262874 |
38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.42195020 |
39 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.42092898 |
40 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.40325337 |
41 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.32361620 |
42 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.32294203 |
43 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.31894403 |
44 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.31377598 |
45 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.31138717 |
46 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.30926432 |
47 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.27550564 |
48 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.24456272 |
49 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.24194388 |
50 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.23048960 |
51 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.19212482 |
52 | ABC transporters_Homo sapiens_hsa02010 | 1.15839907 |
53 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.15539783 |
54 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.13835036 |
55 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.13437298 |
56 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.06705537 |
57 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.03558695 |
58 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.99051279 |
59 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.96182733 |
60 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.91546693 |
61 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.88617766 |
62 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.88540296 |
63 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.88446036 |
64 | Sulfur relay system_Homo sapiens_hsa04122 | 0.87417196 |
65 | Lysine degradation_Homo sapiens_hsa00310 | 0.85852081 |
66 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.84587860 |
67 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.82531112 |
68 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.80933684 |
69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.62585921 |
70 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.58367921 |
71 | Galactose metabolism_Homo sapiens_hsa00052 | 0.58198333 |
72 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.51001572 |
73 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.47596284 |
74 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.37281209 |
75 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.34376847 |
76 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.31105846 |
77 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.23268963 |
78 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.22800534 |
79 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.21941602 |
80 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.20927078 |
81 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.20926985 |
82 | Insulin resistance_Homo sapiens_hsa04931 | 0.18317455 |
83 | Mineral absorption_Homo sapiens_hsa04978 | 0.18044241 |
84 | Pertussis_Homo sapiens_hsa05133 | 0.17671465 |
85 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.15085169 |
86 | Asthma_Homo sapiens_hsa05310 | 0.14099772 |
87 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.13699337 |
88 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.08163802 |
89 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.04492128 |
90 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.02825374 |
91 | Prion diseases_Homo sapiens_hsa05020 | 0.01765169 |
92 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.01697888 |
93 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.01389745 |
94 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.00089693 |
95 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1635835 |
96 | Protein digestion and absorption_Homo sapiens_hsa04974 | -0.1565127 |
97 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.1540379 |
98 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | -0.1474362 |
99 | Legionellosis_Homo sapiens_hsa05134 | -0.1393002 |
100 | Huntingtons disease_Homo sapiens_hsa05016 | -0.1232032 |
101 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | -0.1142362 |
102 | Cardiac muscle contraction_Homo sapiens_hsa04260 | -0.1125951 |
103 | Other glycan degradation_Homo sapiens_hsa00511 | -0.0976501 |
104 | Graft-versus-host disease_Homo sapiens_hsa05332 | -0.0959392 |
105 | Parkinsons disease_Homo sapiens_hsa05012 | -0.0955950 |
106 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0916280 |
107 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | -0.0888942 |
108 | Purine metabolism_Homo sapiens_hsa00230 | -0.0732889 |
109 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | -0.0724382 |
110 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | -0.0698864 |
111 | Allograft rejection_Homo sapiens_hsa05330 | -0.0528223 |
112 | Oxidative phosphorylation_Homo sapiens_hsa00190 | -0.0316338 |
113 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.0085585 |
114 | AMPK signaling pathway_Homo sapiens_hsa04152 | -0.0043853 |