TMEM86B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.65165577
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.65165577
3L-phenylalanine metabolic process (GO:0006558)7.29193560
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.29193560
5aromatic amino acid family catabolic process (GO:0009074)6.88144921
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.46558025
7tryptophan catabolic process (GO:0006569)6.20471125
8indole-containing compound catabolic process (GO:0042436)6.20471125
9indolalkylamine catabolic process (GO:0046218)6.20471125
10kynurenine metabolic process (GO:0070189)6.04741346
11tryptophan metabolic process (GO:0006568)5.85141581
12bile acid biosynthetic process (GO:0006699)5.80678812
13glyoxylate metabolic process (GO:0046487)5.70444437
14high-density lipoprotein particle remodeling (GO:0034375)5.69704247
15urea cycle (GO:0000050)5.68452508
16urea metabolic process (GO:0019627)5.68452508
17negative regulation of fibrinolysis (GO:0051918)5.56610939
18alpha-linolenic acid metabolic process (GO:0036109)5.45967299
19cysteine metabolic process (GO:0006534)5.40310027
20regulation of fibrinolysis (GO:0051917)5.34143171
21protein carboxylation (GO:0018214)5.32515557
22peptidyl-glutamic acid carboxylation (GO:0017187)5.32515557
23sulfur amino acid catabolic process (GO:0000098)5.25526304
24nitrogen cycle metabolic process (GO:0071941)5.22438456
25complement activation, alternative pathway (GO:0006957)5.14575558
26regulation of protein activation cascade (GO:2000257)5.12313397
27serine family amino acid catabolic process (GO:0009071)5.04307299
28regulation of triglyceride catabolic process (GO:0010896)5.01200076
29aromatic amino acid family metabolic process (GO:0009072)4.98827138
30bile acid metabolic process (GO:0008206)4.97898447
31reverse cholesterol transport (GO:0043691)4.97093693
32regulation of cholesterol esterification (GO:0010872)4.95694381
33positive regulation of gamma-delta T cell activation (GO:0046645)4.82982871
34negative regulation of erythrocyte differentiation (GO:0045647)4.82489684
35cellular extravasation (GO:0045123)4.81888629
36plasma lipoprotein particle remodeling (GO:0034369)4.81268553
37protein-lipid complex remodeling (GO:0034368)4.81268553
38macromolecular complex remodeling (GO:0034367)4.81268553
39tyrosine metabolic process (GO:0006570)4.80613651
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78272942
41regulation of complement activation (GO:0030449)4.77705056
42phospholipid efflux (GO:0033700)4.77200912
43negative regulation of cholesterol transport (GO:0032375)4.74094549
44negative regulation of sterol transport (GO:0032372)4.74094549
45negative regulation of cell killing (GO:0031342)4.73843839
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.73843839
47lysine metabolic process (GO:0006553)4.64148632
48lysine catabolic process (GO:0006554)4.64148632
49homocysteine metabolic process (GO:0050667)4.64105121
50triglyceride homeostasis (GO:0070328)4.62745312
51acylglycerol homeostasis (GO:0055090)4.62745312
52alpha-amino acid catabolic process (GO:1901606)4.60728648
53amino-acid betaine metabolic process (GO:0006577)4.48410027
54indolalkylamine metabolic process (GO:0006586)4.43983064
55bile acid and bile salt transport (GO:0015721)4.41451181
56coenzyme catabolic process (GO:0009109)4.41269192
57drug catabolic process (GO:0042737)4.41195548
58glycine metabolic process (GO:0006544)4.36716697
59modulation by symbiont of host defense response (GO:0052031)4.36205289
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36205289
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36205289
62positive regulation by organism of defense response of other organism involved in symbiotic interact4.36205289
63modulation by symbiont of host immune response (GO:0052553)4.36205289
64positive regulation by symbiont of host defense response (GO:0052509)4.36205289
65cholesterol efflux (GO:0033344)4.35574326
66plasma lipoprotein particle clearance (GO:0034381)4.35396090
67cellular biogenic amine catabolic process (GO:0042402)4.32870962
68amine catabolic process (GO:0009310)4.32870962
69imidazole-containing compound metabolic process (GO:0052803)4.31443923
70neutrophil activation involved in immune response (GO:0002283)4.30043168
71detection of bacterium (GO:0016045)4.29770682
72cellular ketone body metabolic process (GO:0046950)4.28844550
73glutamate metabolic process (GO:0006536)4.28185427
74epoxygenase P450 pathway (GO:0019373)4.25459477
75detection of other organism (GO:0098543)4.23792550
76cellular amino acid catabolic process (GO:0009063)4.22661731
77plasma lipoprotein particle assembly (GO:0034377)4.21921574
78antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17026438
79serine family amino acid metabolic process (GO:0009069)4.16299781
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15338150
81cellular glucuronidation (GO:0052695)4.14895115
82benzene-containing compound metabolic process (GO:0042537)4.11698430
83antigen processing and presentation of endogenous antigen (GO:0019883)4.06736728
84response to peptidoglycan (GO:0032494)4.05792500
85positive regulation of triglyceride lipase activity (GO:0061365)4.04492882
86positive regulation of lipoprotein lipase activity (GO:0051006)4.04492882
87ethanol oxidation (GO:0006069)4.03462739
88cellular modified amino acid catabolic process (GO:0042219)4.03441796
89arginine metabolic process (GO:0006525)4.03337682
90dicarboxylic acid biosynthetic process (GO:0043650)4.00955494
91serine family amino acid biosynthetic process (GO:0009070)3.99133360
92exogenous drug catabolic process (GO:0042738)3.93474908
93very-low-density lipoprotein particle assembly (GO:0034379)3.89919042
94fibrinolysis (GO:0042730)3.89749920
95low-density lipoprotein particle remodeling (GO:0034374)3.85851042
96macrophage activation involved in immune response (GO:0002281)3.85281017
97cofactor catabolic process (GO:0051187)3.83853180
98blood coagulation, intrinsic pathway (GO:0007597)3.83628382
99aldehyde catabolic process (GO:0046185)3.83292130
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80397654
101protein-lipid complex assembly (GO:0065005)3.78464598
102flavonoid metabolic process (GO:0009812)3.78200029
103cholesterol homeostasis (GO:0042632)3.77095486
104positive regulation of lipid catabolic process (GO:0050996)3.76392391
105plasma lipoprotein particle organization (GO:0071827)3.73961118
106regulation of cholesterol homeostasis (GO:2000188)3.73830756
107negative regulation of lipase activity (GO:0060192)3.73661201
108complement activation, classical pathway (GO:0006958)3.72591431
109phospholipid homeostasis (GO:0055091)3.71990668
110regulation of gamma-delta T cell activation (GO:0046643)3.71507638
111sterol homeostasis (GO:0055092)3.70516456
112ketone body metabolic process (GO:1902224)3.69978670
113regulation of bile acid biosynthetic process (GO:0070857)3.68498269
114leukocyte aggregation (GO:0070486)3.67955560
115carboxylic acid catabolic process (GO:0046395)3.66153531
116organic acid catabolic process (GO:0016054)3.66153531
117intestinal cholesterol absorption (GO:0030299)3.63993311
118protein activation cascade (GO:0072376)3.63863972
119complement activation (GO:0006956)3.63463334
120glucuronate metabolic process (GO:0019585)3.63237649
121uronic acid metabolic process (GO:0006063)3.63237649
122short-chain fatty acid metabolic process (GO:0046459)3.62672939
123regulation of B cell receptor signaling pathway (GO:0050855)3.60858399
124oxygen transport (GO:0015671)3.60576370
125positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.55534095
126detection of external biotic stimulus (GO:0098581)3.51177930
127regulation of gamma-delta T cell differentiation (GO:0045586)3.48875853
128regulation of interferon-beta biosynthetic process (GO:0045357)3.47682331
129positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44904205
130disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.42263791
131killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.42263791
132negative regulation of phagocytosis (GO:0050765)3.33184032
133mannose metabolic process (GO:0006013)3.29222721
134negative regulation of lymphocyte mediated immunity (GO:0002707)3.27781784
135neutrophil mediated immunity (GO:0002446)3.27344732
136microglial cell activation (GO:0001774)3.25210959
137positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.24609432
138neutrophil activation (GO:0042119)3.20167466
139response to muramyl dipeptide (GO:0032495)3.17639794
140regulation of mast cell degranulation (GO:0043304)3.17096100
141regulation of myeloid leukocyte mediated immunity (GO:0002886)3.14585273
142hemoglobin metabolic process (GO:0020027)3.14507268
143positive thymic T cell selection (GO:0045059)3.13992160
144leukocyte migration involved in inflammatory response (GO:0002523)3.13608506
145germinal center formation (GO:0002467)3.13336233
146positive regulation of B cell differentiation (GO:0045579)3.13067860
147modulation by virus of host process (GO:0019054)3.12199151
148B cell receptor signaling pathway (GO:0050853)3.07212836
149negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.05438576
150macrophage activation (GO:0042116)3.05090996
151detection of biotic stimulus (GO:0009595)3.04036619
152negative regulation of leukocyte mediated immunity (GO:0002704)3.03549166
153respiratory burst (GO:0045730)3.03440743
154regulation of leukocyte degranulation (GO:0043300)3.01033423
155granulocyte activation (GO:0036230)3.00546835
156response to interleukin-15 (GO:0070672)2.98288920
157regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97627143
158positive regulation of granulocyte differentiation (GO:0030854)2.94897085
159myeloid cell activation involved in immune response (GO:0002275)2.93305885
160tolerance induction (GO:0002507)2.93277348
161negative regulation of interleukin-12 production (GO:0032695)2.93229982
162detection of molecule of bacterial origin (GO:0032490)2.92577045
163regulation of B cell differentiation (GO:0045577)2.92152882
164immunoglobulin mediated immune response (GO:0016064)2.91002039
165gas transport (GO:0015669)2.90532798
166erythrocyte maturation (GO:0043249)2.89442727
167modulation by symbiont of host cellular process (GO:0044068)2.88377235
168negative regulation of cytokine production involved in immune response (GO:0002719)2.86260854
169NIK/NF-kappaB signaling (GO:0038061)2.86069401
170negative thymic T cell selection (GO:0045060)2.85697872
171response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85603805
172response to host immune response (GO:0052572)2.85603805
173lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83788265
174regulation of mast cell activation involved in immune response (GO:0033006)2.83074305
175cellular response to virus (GO:0098586)2.82621173
176thymic T cell selection (GO:0045061)2.79287256
177leukocyte degranulation (GO:0043299)2.75503073
178T cell selection (GO:0045058)2.71544579
179response to type I interferon (GO:0034340)2.71381922
180positive regulation of histone deacetylation (GO:0031065)2.71050915
1813-UTR-mediated mRNA stabilization (GO:0070935)2.71048484
182response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.69888117
183response to host (GO:0075136)2.69888117
184response to host defenses (GO:0052200)2.69888117
185regulation of granulocyte differentiation (GO:0030852)2.69428798
186protoporphyrinogen IX metabolic process (GO:0046501)2.69220651
187type I interferon signaling pathway (GO:0060337)2.68549373
188cellular response to type I interferon (GO:0071357)2.68549373
189megakaryocyte development (GO:0035855)2.67944128
190T cell migration (GO:0072678)2.66987379
191negative T cell selection (GO:0043383)2.66768703
192regulation of superoxide anion generation (GO:0032928)2.65624875
193positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63004803
194regulation of ARF GTPase activity (GO:0032312)2.59003846
195negative regulation of interleukin-6 production (GO:0032715)2.58745158
196myeloid leukocyte mediated immunity (GO:0002444)2.58421313
197negative regulation of T cell mediated immunity (GO:0002710)2.58257841
198regulation of T-helper 2 cell differentiation (GO:0045628)2.56599485
199production of molecular mediator involved in inflammatory response (GO:0002532)2.55563311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.36204969
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19919672
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07723779
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.43531464
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24187447
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.13216215
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.52540184
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.99019208
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.95005030
10VDR_21846776_ChIP-Seq_THP-1_Human3.60543259
11MYC_22102868_ChIP-Seq_BL_Human3.14615925
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59163004
13VDR_24763502_ChIP-Seq_THP-1_Human2.48254817
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.45610250
15TCF7_22412390_ChIP-Seq_EML_Mouse2.45539051
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.36642839
17* MAF_26560356_Chip-Seq_TH1_Human2.28520902
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.27898691
19KDM2B_26808549_Chip-Seq_DND41_Human2.22102990
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.17770299
21UTX_26944678_Chip-Seq_JUKART_Human2.15088869
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08182818
23* RUNX1_22412390_ChIP-Seq_EML_Mouse2.03947515
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9616793
25* MAF_26560356_Chip-Seq_TH2_Human1.98198196
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96517400
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94133802
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92047163
29SPI1_23127762_ChIP-Seq_K562_Human1.90034176
30GATA1_22025678_ChIP-Seq_K562_Human1.83447247
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82623794
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.80524903
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.78808531
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.77105555
35SPI1_23547873_ChIP-Seq_NB4_Human1.75682900
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69670696
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68399019
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68241064
39P68_20966046_ChIP-Seq_HELA_Human1.66611777
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65691477
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64598795
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59292071
43RACK7_27058665_Chip-Seq_MCF-7_Human1.59291666
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.58604179
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.57056339
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55352922
47MYB_26560356_Chip-Seq_TH1_Human1.55131579
48* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54879635
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54454106
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.49473711
51NCOR1_26117541_ChIP-Seq_K562_Human1.48710817
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.46471393
53* SA1_27219007_Chip-Seq_ERYTHROID_Human1.45799865
54MYB_26560356_Chip-Seq_TH2_Human1.44798365
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41905582
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41376344
57HNF4A_19822575_ChIP-Seq_HepG2_Human1.40690391
58HTT_18923047_ChIP-ChIP_STHdh_Human1.40585804
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40145555
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38271075
61CLOCK_20551151_ChIP-Seq_293T_Human1.36852049
62KDM2B_26808549_Chip-Seq_K562_Human1.34785892
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33476195
64RUNX_20019798_ChIP-Seq_JUKART_Human1.32087239
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30303991
66SMC4_20622854_ChIP-Seq_HELA_Human1.27928879
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26627693
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26016186
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24970723
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.22412498
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21752602
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20273695
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18948641
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18718615
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18302746
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17632560
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15877563
78PHF8_20622854_ChIP-Seq_HELA_Human1.14078235
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11186815
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07921418
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07265398
82E2F1_20622854_ChIP-Seq_HELA_Human1.06942432
83CREB1_26743006_Chip-Seq_LNCaP_Human1.06893706
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03897619
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02686743
86CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02583951
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02327207
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01827963
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00749988
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00747299
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00299412
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97993658
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90283258
94* GATA1_19941827_ChIP-Seq_MEL_Mouse0.89682391
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88364283
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87741585
97GATA4_25053715_ChIP-Seq_YYC3_Human0.82114327
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.81721701
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81654851
100GATA1_19941826_ChIP-Seq_K562_Human0.79845797
101LXR_22292898_ChIP-Seq_THP-1_Human0.75949635
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75313313
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74733394
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74500330
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74293655
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73828120
107ZNF263_19887448_ChIP-Seq_K562_Human0.70372567
108RARB_24833708_ChIP-Seq_LIVER_Mouse0.69982221
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69731824
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69124258
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65712622
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65555244
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65102706
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64965008
115GATA2_19941826_ChIP-Seq_K562_Human0.64480572
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.63523834
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.61006097
118CEBPB_22108803_ChIP-Seq_LS180_Human0.60414194
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57827299
120RARG_19884340_ChIP-ChIP_MEFs_Mouse0.57645113
121EGR1_19032775_ChIP-ChIP_M12_Human0.57558213
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.57404089
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.56965129
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56753883
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56085167
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.53051287
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.52577606
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52480988
129MYC_19915707_ChIP-ChIP_AK7_Human0.52300830
130BCOR_27268052_Chip-Seq_Bcells_Human0.52214964
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.52131321
132BRD4_27068464_Chip-Seq_AML-cells_Mouse0.51974979
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51533021
134AR_20517297_ChIP-Seq_VCAP_Human0.50923897
135* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.50289378
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.49859888
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.49830266
138GATA6_25053715_ChIP-Seq_YYC3_Human0.49431387
139* SCL_19346495_ChIP-Seq_HPC-7_Human0.49044102
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.48688136
141P53_21459846_ChIP-Seq_SAOS-2_Human0.47134783
142RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.46899195
143CDX2_20551321_ChIP-Seq_CACO-2_Human0.45903465
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.45254555
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45246027
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45238520
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.44957861
148TAF2_19829295_ChIP-Seq_ESCs_Human0.44799641
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.44739407
150SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44391594
151TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.44020883
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43289810
153BCL6_27268052_Chip-Seq_Bcells_Human0.42888376
154NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.42319275
155CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.41936393
156IRF8_27001747_Chip-Seq_BMDM_Mouse0.41566458
157* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.41562616
158STAT1_17558387_ChIP-Seq_HELA_Human0.40732415
159CBP_21632823_ChIP-Seq_H3396_Human0.40058045
160IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.39853217
161SPI1_26923725_Chip-Seq_HPCs_Mouse0.39588096
162MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.39377121
163PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.39226412
164P300_27268052_Chip-Seq_Bcells_Human0.38140853
165LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.37776539
166CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37176071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.25904982
2MP0005360_urolithiasis7.70317589
3MP0005085_abnormal_gallbladder_physiolo6.29649333
4MP0005365_abnormal_bile_salt6.05069835
5MP0008875_abnormal_xenobiotic_pharmacok5.30586141
6MP0003806_abnormal_nucleotide_metabolis4.18055007
7MP0003303_peritoneal_inflammation3.94037281
8MP0003252_abnormal_bile_duct3.87538594
9MP0010329_abnormal_lipoprotein_level3.56181061
10MP0009840_abnormal_foam_cell3.39547297
11MP0003172_abnormal_lysosome_physiology3.07072513
12MP0005083_abnormal_biliary_tract3.02582314
13MP0001666_abnormal_nutrient_absorption2.72696853
14MP0001835_abnormal_antigen_presentation2.71542253
15MP0005332_abnormal_amino_acid2.67179008
16MP0003195_calcinosis2.64016462
17MP0008260_abnormal_autophagy2.38718690
18MP0001800_abnormal_humoral_immune2.35121405
19MP0005000_abnormal_immune_tolerance2.31710465
20MP0003191_abnormal_cellular_cholesterol2.31651654
21MP0001790_abnormal_immune_system2.27444462
22MP0005387_immune_system_phenotype2.27444462
23MP0000609_abnormal_liver_physiology2.19509240
24MP0009278_abnormal_bone_marrow2.16814244
25MP0003763_abnormal_thymus_physiology2.12233145
26MP0002420_abnormal_adaptive_immunity2.10496687
27MP0004019_abnormal_vitamin_homeostasis2.09404278
28MP0002723_abnormal_immune_serum2.08632108
29MP0001819_abnormal_immune_cell2.07382514
30MP0002118_abnormal_lipid_homeostasis2.06161358
31MP0005671_abnormal_response_to1.96728338
32MP0009333_abnormal_splenocyte_physiolog1.95922437
33MP0002452_abnormal_antigen_presenting1.93931559
34MP0002405_respiratory_system_inflammati1.93346778
35MP0003300_gastrointestinal_ulcer1.93342994
36MP0003868_abnormal_feces_composition1.92569131
37MP0002138_abnormal_hepatobiliary_system1.92086265
38MP0002398_abnormal_bone_marrow1.88047590
39MP0005397_hematopoietic_system_phenotyp1.87530760
40MP0001545_abnormal_hematopoietic_system1.87530760
41MP0005319_abnormal_enzyme/_coenzyme1.87013117
42MP0003656_abnormal_erythrocyte_physiolo1.83364865
43MP0002396_abnormal_hematopoietic_system1.78329540
44MP0001764_abnormal_homeostasis1.67228592
45MP0000716_abnormal_immune_system1.66906549
46MP0010155_abnormal_intestine_physiology1.63158744
47MP0009697_abnormal_copulation1.61015480
48MP0005584_abnormal_enzyme/coenzyme_acti1.58555892
49MP0001533_abnormal_skeleton_physiology1.57375964
50MP0002722_abnormal_immune_system1.57358914
51MP0000689_abnormal_spleen_morphology1.55130872
52MP0005076_abnormal_cell_differentiation1.54926527
53MP0002429_abnormal_blood_cell1.47605221
54MP0002148_abnormal_hypersensitivity_rea1.43877909
55MP0001873_stomach_inflammation1.39751464
56MP0003866_abnormal_defecation1.39638390
57MP0003011_delayed_dark_adaptation1.38369847
58MP0000703_abnormal_thymus_morphology1.36098627
59MP0005451_abnormal_body_composition1.35768420
60MP0009643_abnormal_urine_homeostasis1.25298957
61MP0004510_myositis1.24925516
62MP0005310_abnormal_salivary_gland1.22223340
63MP0003186_abnormal_redox_activity1.22111991
64MP0003183_abnormal_peptide_metabolism1.21458456
65MP0000598_abnormal_liver_morphology1.20825203
66MP0000858_altered_metastatic_potential1.18194577
67MP0003878_abnormal_ear_physiology1.16144570
68MP0005377_hearing/vestibular/ear_phenot1.16144570
69MP0009764_decreased_sensitivity_to1.15667214
70MP0001851_eye_inflammation1.11416057
71MP0003828_pulmonary_edema1.07397474
72MP0000015_abnormal_ear_pigmentation1.07294886
73MP0009763_increased_sensitivity_to1.06084656
74MP0000604_amyloidosis1.03993208
75MP0005075_abnormal_melanosome_morpholog1.03487715
76MP0003705_abnormal_hypodermis_morpholog1.01483933
77MP0005647_abnormal_sex_gland1.00079654
78MP0004808_abnormal_hematopoietic_stem0.99929983
79MP0008469_abnormal_protein_level0.98853845
80MP0005636_abnormal_mineral_homeostasis0.98007986
81MP0003123_paternal_imprinting0.97780611
82MP0002998_abnormal_bone_remodeling0.97670885
83MP0002933_joint_inflammation0.93825183
84MP0009642_abnormal_blood_homeostasis0.89826202
85MP0001663_abnormal_digestive_system0.88875528
86MP0009765_abnormal_xenobiotic_induced0.88133527
87MP0001986_abnormal_taste_sensitivity0.87151061
88MP0002254_reproductive_system_inflammat0.86266381
89MP0006036_abnormal_mitochondrial_physio0.83522687
90MP0005084_abnormal_gallbladder_morpholo0.79834036
91MP0010368_abnormal_lymphatic_system0.78777699
92MP0002078_abnormal_glucose_homeostasis0.78611664
93MP0005376_homeostasis/metabolism_phenot0.77706716
94MP0005164_abnormal_response_to0.77633100
95MP0005464_abnormal_platelet_physiology0.74734933
96MP0003453_abnormal_keratinocyte_physiol0.74453192
97MP0005408_hypopigmentation0.72004410
98MP0002166_altered_tumor_susceptibility0.71860487
99MP0005334_abnormal_fat_pad0.70877956
100MP0002971_abnormal_brown_adipose0.70429736
101MP0000465_gastrointestinal_hemorrhage0.70336980
102MP0003045_fibrosis0.69232552
103MP0005535_abnormal_body_temperature0.68826624
104MP0005220_abnormal_exocrine_pancreas0.68757310
105MP0003436_decreased_susceptibility_to0.68585078
106MP0003879_abnormal_hair_cell0.68485305
107MP0002332_abnormal_exercise_endurance0.68262845
108MP0005670_abnormal_white_adipose0.68252977
109MP0000490_abnormal_crypts_of0.68164207
110MP0004185_abnormal_adipocyte_glucose0.67046571
111MP0000343_altered_response_to0.64491130
112MP0005266_abnormal_metabolism0.64245514
113MP0002876_abnormal_thyroid_physiology0.63114085
114MP0002822_catalepsy0.62556200
115MP0003690_abnormal_glial_cell0.59232468
116MP0005448_abnormal_energy_balance0.57834994
117MP0003724_increased_susceptibility_to0.56805443
118MP0003329_amyloid_beta_deposits0.56438282
119MP0001756_abnormal_urination0.55839901
120MP0004130_abnormal_muscle_cell0.55747902
121MP0006035_abnormal_mitochondrial_morpho0.54714127
122MP0008874_decreased_physiological_sensi0.53472187
123MP0008873_increased_physiological_sensi0.52627656
124MP0008872_abnormal_physiological_respon0.52046616
125MP0000639_abnormal_adrenal_gland0.51046877
126MP0009053_abnormal_anal_canal0.50647161
127MP0001661_extended_life_span0.50550075
128MP0002928_abnormal_bile_duct0.49454584
129MP0004147_increased_porphyrin_level0.49436904
130MP0006082_CNS_inflammation0.48554696
131MP0003638_abnormal_response/metabolism_0.47904852
132MP0002136_abnormal_kidney_physiology0.46774889
133MP0001853_heart_inflammation0.45460655
134MP0004782_abnormal_surfactant_physiolog0.44634505
135MP0003075_altered_response_to0.43647492
136MP0001845_abnormal_inflammatory_respons0.42108269
137MP0003953_abnormal_hormone_level0.39762303
138MP0005166_decreased_susceptibility_to0.39468431
139MP0009115_abnormal_fat_cell0.38442220
140MP0005395_other_phenotype0.37639714
141MP0004381_abnormal_hair_follicle0.37471672
142MP0002132_abnormal_respiratory_system0.36796248
143MP0002970_abnormal_white_adipose0.35837291
144MP0003718_maternal_effect0.35598838
145MP0009672_abnormal_birth_weight0.35241013
146MP0000249_abnormal_blood_vessel0.33392949
147MP0004947_skin_inflammation0.29908076
148MP0005025_abnormal_response_to0.29068208
149MP0001243_abnormal_dermal_layer0.28853788
150MP0005248_abnormal_Harderian_gland0.28671687
151MP0004883_abnormal_blood_vessel0.27671906
152MP0009785_altered_susceptibility_to0.27564729
153MP0002837_dystrophic_cardiac_calcinosis0.26663308
154MP0005666_abnormal_adipose_tissue0.25717101
155MP0004264_abnormal_extraembryonic_tissu0.25660645
156MP0002419_abnormal_innate_immunity0.23567538
157MP0000685_abnormal_immune_system0.23387434
158MP0005058_abnormal_lysosome_morphology0.23205475
159MP0001944_abnormal_pancreas_morphology0.22330828

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.51317908
2Deep venous thrombosis (HP:0002625)7.22092066
3Intrahepatic cholestasis (HP:0001406)7.05090364
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.58010250
5Hypobetalipoproteinemia (HP:0003563)6.50588649
6Prolonged partial thromboplastin time (HP:0003645)6.49432876
7Xanthomatosis (HP:0000991)6.12153683
8Hyperlipoproteinemia (HP:0010980)5.55990258
9Complement deficiency (HP:0004431)5.13174840
10Eczematoid dermatitis (HP:0000976)4.86692695
11Joint hemorrhage (HP:0005261)4.82358029
12Hypolipoproteinemia (HP:0010981)4.74005908
13Hypochromic anemia (HP:0001931)4.54801987
14Hyperammonemia (HP:0001987)4.47173952
15Recurrent abscess formation (HP:0002722)4.34164458
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.31738836
17Ketosis (HP:0001946)4.30008626
18Abnormality of the common coagulation pathway (HP:0010990)4.29493968
19Hyperglycinemia (HP:0002154)4.27445579
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.24382741
21Epidermoid cyst (HP:0200040)4.23718615
22Abnormality of the heme biosynthetic pathway (HP:0010472)4.18497849
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.17689086
24Recurrent bacterial skin infections (HP:0005406)4.13928312
25Abnormality of macrophages (HP:0004311)4.13491728
26Abnormality of methionine metabolism (HP:0010901)4.08171656
27Myositis (HP:0100614)4.06863004
28Fat malabsorption (HP:0002630)4.02657344
29Hypoalphalipoproteinemia (HP:0003233)4.02146015
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.96558371
31Prolonged bleeding time (HP:0003010)3.95449769
32Abnormality of pyrimidine metabolism (HP:0004353)3.91938325
33Hyperglycinuria (HP:0003108)3.85454688
34Abnormality of glycine metabolism (HP:0010895)3.84607627
35Abnormality of serine family amino acid metabolism (HP:0010894)3.84607627
36Chronic obstructive pulmonary disease (HP:0006510)3.81103677
37Obstructive lung disease (HP:0006536)3.81103677
38Hypoglycemic coma (HP:0001325)3.72909183
39Abnormality of complement system (HP:0005339)3.72636838
40Conjugated hyperbilirubinemia (HP:0002908)3.70626665
41Abnormality of the intrinsic pathway (HP:0010989)3.70330424
42Hyperbilirubinemia (HP:0002904)3.63039289
43Hypercholesterolemia (HP:0003124)3.58289681
44Orchitis (HP:0100796)3.47044527
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44768553
46Hypochromic microcytic anemia (HP:0004840)3.43621021
47Gastrointestinal infarctions (HP:0005244)3.42820307
48Stomatitis (HP:0010280)3.39743734
49Abnormal delayed hypersensitivity skin test (HP:0002963)3.35096095
50Meningitis (HP:0001287)3.32240546
51Abnormality of fatty-acid metabolism (HP:0004359)3.26975383
52Recurrent fungal infections (HP:0002841)3.26590378
53Elevated erythrocyte sedimentation rate (HP:0003565)3.19548504
54Microcytic anemia (HP:0001935)3.16397826
55Epistaxis (HP:0000421)3.16157322
56Retrobulbar optic neuritis (HP:0100654)3.15221405
57Optic neuritis (HP:0100653)3.15221405
58Abnormality of nucleobase metabolism (HP:0010932)3.14451711
59Mediastinal lymphadenopathy (HP:0100721)3.09107596
60Increased IgE level (HP:0003212)3.07670395
61Acanthocytosis (HP:0001927)3.05356977
62Recurrent skin infections (HP:0001581)3.03741160
63Delayed CNS myelination (HP:0002188)3.02781503
64Hepatocellular carcinoma (HP:0001402)3.00295095
65Steatorrhea (HP:0002570)2.99419373
66Ketoacidosis (HP:0001993)2.92320311
67Myocardial infarction (HP:0001658)2.91353241
68Pustule (HP:0200039)2.90888891
69Spontaneous abortion (HP:0005268)2.90487288
70Cellulitis (HP:0100658)2.89814886
71Abnormality of serum amino acid levels (HP:0003112)2.85899408
72Polycythemia (HP:0001901)2.83359276
73Gastrointestinal inflammation (HP:0004386)2.82196763
74Metabolic acidosis (HP:0001942)2.79622708
75Poikilocytosis (HP:0004447)2.77680143
76Petechiae (HP:0000967)2.77582802
77Purpura (HP:0000979)2.77530726
78Abnormality of purine metabolism (HP:0004352)2.75708405
79Inflammation of the large intestine (HP:0002037)2.73480853
80Systemic lupus erythematosus (HP:0002725)2.72742612
81Urticaria (HP:0001025)2.71262980
82Recurrent cutaneous fungal infections (HP:0011370)2.69798328
83Chronic mucocutaneous candidiasis (HP:0002728)2.69798328
84Gingivitis (HP:0000230)2.69539402
85Vasculitis (HP:0002633)2.68018603
86Abnormal gallbladder morphology (HP:0012437)2.67835596
87Slow saccadic eye movements (HP:0000514)2.66324795
88Encephalitis (HP:0002383)2.65804642
89Spontaneous hematomas (HP:0007420)2.65752851
90Cholelithiasis (HP:0001081)2.63842394
91Skin nodule (HP:0200036)2.61861993
92Abnormality of polysaccharide metabolism (HP:0011012)2.49458833
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49458833
94Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49458833
95Recurrent gram-negative bacterial infections (HP:0005420)2.49356408
96Vascular calcification (HP:0004934)2.48217438
97Panhypogammaglobulinemia (HP:0003139)2.47733382
98Colitis (HP:0002583)2.46789235
99Lethargy (HP:0001254)2.46345096
100Dicarboxylic aciduria (HP:0003215)2.45692672
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45692672
102Keratoconjunctivitis sicca (HP:0001097)2.45626483
103Hypoglycemic seizures (HP:0002173)2.43865332
104Recurrent viral infections (HP:0004429)2.43043902
105Dysostosis multiplex (HP:0000943)2.43030803
106Cholecystitis (HP:0001082)2.40565201
107Abnormal gallbladder physiology (HP:0012438)2.40565201
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.39687294
109Spastic diplegia (HP:0001264)2.39043651
110Mitral stenosis (HP:0001718)2.38296681
111Episodic fever (HP:0001954)2.37243909
112Gingival bleeding (HP:0000225)2.36110700
113Gout (HP:0001997)2.35378781
114Amyloidosis (HP:0011034)2.34204182
115Irritability (HP:0000737)2.32457952
116Mucopolysacchariduria (HP:0008155)2.32447021
117Urinary glycosaminoglycan excretion (HP:0003541)2.32447021
118Granulocytopenia (HP:0001913)2.31353765
119Chest pain (HP:0100749)2.31329434
120Malnutrition (HP:0004395)2.30226370
121Neonatal onset (HP:0003623)2.29714831
122Glomerulonephritis (HP:0000099)2.28084975
123Cerebral edema (HP:0002181)2.24900218
124Abnormality of the fingertips (HP:0001211)2.24718617
125Increased cerebral lipofuscin (HP:0011813)2.24220422
126Anorexia (HP:0002039)2.23348418
127Menorrhagia (HP:0000132)2.23285109
128Keratoconjunctivitis (HP:0001096)2.22543762
129Late onset (HP:0003584)2.18486360
130Reticulocytosis (HP:0001923)2.16637179
131Thrombophlebitis (HP:0004418)2.15724431
132Abnormality of the gallbladder (HP:0005264)2.15419199
133Cardiovascular calcification (HP:0011915)2.15144385
134Brushfield spots (HP:0001088)2.15097768
135Hypertriglyceridemia (HP:0002155)2.13718562
136Pancreatitis (HP:0001733)2.12846161
137Sensorimotor neuropathy (HP:0007141)2.12752275
138Abnormal platelet function (HP:0011869)2.11962098
139Impaired platelet aggregation (HP:0003540)2.11962098
140Increased neuronal autofluorescent lipopigment (HP:0002074)2.11193399
141Hypertensive crisis (HP:0100735)2.10199612
142Enlarged kidneys (HP:0000105)2.10127852
143Hemorrhage of the eye (HP:0011885)2.09395653
144Abnormal platelet volume (HP:0011876)2.09206359
145Esophageal varix (HP:0002040)2.08781807
146Pulmonary infiltrates (HP:0002113)2.08752121
147Vomiting (HP:0002013)2.05955435
148Abnormality of iron homeostasis (HP:0011031)2.05942340
149Hemoptysis (HP:0002105)2.04497969
150Generalized aminoaciduria (HP:0002909)2.02485859
151Osteomyelitis (HP:0002754)2.00922113
152Loss of speech (HP:0002371)2.00222781
153Abnormality of transition element cation homeostasis (HP:0011030)1.99965118
154Hyperinsulinemic hypoglycemia (HP:0000825)1.98938511
155Polygenic inheritance (HP:0010982)1.98529502
156Arterial thrombosis (HP:0004420)1.98371688
157Abnormality of T cell physiology (HP:0011840)1.97883808
158Abnormal hemoglobin (HP:0011902)1.97876085
159Increased IgM level (HP:0003496)1.96400781
160Opisthotonus (HP:0002179)1.95385875
161Thrombocytosis (HP:0001894)1.95159470
162Acne (HP:0001061)1.94762039
163Agammaglobulinemia (HP:0004432)1.92940635
164Rickets (HP:0002748)1.92505206
165Hydroxyprolinuria (HP:0003080)1.91788745
166Abnormality of proline metabolism (HP:0010907)1.91788745
167Leukocytosis (HP:0001974)1.91575045
168Hypergammaglobulinemia (HP:0010702)1.91054082
169Viral hepatitis (HP:0006562)1.90569176
170Status epilepticus (HP:0002133)1.88996896
171Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88283270
172Elevated hepatic transaminases (HP:0002910)1.87643277
173Lymphopenia (HP:0001888)1.85239599
174Abnormal enzyme/coenzyme activity (HP:0012379)1.83182033
175Renal cortical cysts (HP:0000803)1.82457085
176Abnormal cartilage morphology (HP:0002763)1.76422706
177Pulmonary embolism (HP:0002204)1.76256809
178Hypophosphatemic rickets (HP:0004912)1.75894836
179Alkalosis (HP:0001948)1.74260223
180Increased serum ferritin (HP:0003281)1.69646561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.73398332
2ERN14.56206496
3FGFR44.43318851
4SIK14.30178535
5TAOK33.50955057
6RIPK43.46400714
7INSRR3.17616302
8PRPF4B2.94539030
9TNK22.57262449
10IRAK42.49692838
11TAOK12.45390855
12ERBB42.17663911
13PKN22.09995415
14MAP2K42.07269290
15GRK61.99602521
16MAPK111.96504368
17SMG11.93884083
18TYK21.89279116
19MAP3K101.88798505
20FLT31.75754242
21TBK11.58759801
22TRIB31.57647439
23FES1.56870942
24PTK61.56684738
25PIK3CG1.50544687
26DAPK21.49848300
27MST1R1.48695056
28SIK31.47475945
29MAP4K11.41410798
30MARK21.40701657
31ABL21.34114529
32MAP3K141.33837618
33CDK121.30706415
34JAK21.29973303
35HCK1.22395682
36IRAK21.20246878
37MAP3K71.19356273
38PRKD21.15889954
39FGR1.14469017
40PRKAA21.14433789
41MAP2K31.13337682
42EEF2K1.11861591
43KSR21.10714338
44JAK11.09395929
45DYRK1B1.09087231
46IRAK31.07657475
47KDR1.06815987
48IKBKE1.06444292
49MAPK41.06156548
50ERBB21.05493063
51EPHB11.05425172
52FRK1.02153001
53MAP3K111.01766481
54MAPK150.99229226
55CDC42BPA0.97852671
56HIPK20.96975149
57MAPK120.96809239
58NEK90.95358216
59CDK60.95067244
60CSK0.91509910
61BMX0.86945174
62PINK10.85392228
63CAMK1D0.84899815
64MARK30.83704813
65TGFBR20.82885031
66LCK0.81798025
67PRKCZ0.77129816
68SGK30.76476178
69FGFR20.75563994
70CSF1R0.75239478
71LATS10.72530161
72MATK0.72009350
73PRKACG0.71980847
74MAP3K30.71214963
75PRKAA10.70825175
76IRAK10.70280579
77RIPK10.67417406
78PRKCQ0.65928254
79ICK0.64997942
80FGFR30.64429223
81MAP2K60.63597663
82CDK40.63542824
83TXK0.62879482
84MAP3K20.62714533
85RPS6KL10.61889265
86RPS6KC10.61889265
87SIK20.59463143
88TESK20.59258155
89PTK2B0.59240644
90GSK3A0.56330112
91MAP3K130.56329638
92MAPK70.54668406
93PKN10.52957415
94RPS6KA20.51902917
95RPS6KA60.49990083
96CAMK2G0.49861834
97BTK0.49395434
98PRKG20.48468747
99STK100.48381380
100PDPK10.48349458
101CAMK1G0.47201029
102MAP3K80.46239530
103SGK20.45837014
104MAP3K50.45797425
105GRK10.45382859
106CAMK40.44974279
107EPHA30.43881055
108IKBKB0.43077085
109PTK20.42679529
110CSNK1G10.40917583
111STK110.39859527
112ITK0.39817942
113STK380.39465467
114PDK10.39323260
115MAP3K10.39150350
116TIE10.39097649
117JAK30.39064642
118ZAP700.38531487
119MAPKAPK20.38225227
120MTOR0.37824281
121CHUK0.37506987
122FYN0.37309481
123SYK0.37171610
124KIT0.37009822
125MAP3K60.36765772
126RPS6KA10.36696644
127EGFR0.36606698
128MAP2K20.36559635
129CAMKK10.33966892
130TEC0.32545249
131YES10.32525266
132RET0.32282528
133IGF1R0.30964596
134SGK4940.30711530
135SGK2230.30711530
136PRKCH0.30118290
137LYN0.30031950
138STK40.28929748
139TAOK20.26789642
140CSNK1G30.25917781
141CSNK1G20.24538799
142ABL10.24375500
143MAPK30.24218402
144BLK0.23512583

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.50007740
2Nitrogen metabolism_Homo sapiens_hsa009103.42011829
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37459211
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.34299492
5Arginine biosynthesis_Homo sapiens_hsa002203.04205542
6Other glycan degradation_Homo sapiens_hsa005112.92010531
7Tryptophan metabolism_Homo sapiens_hsa003802.79694457
8Osteoclast differentiation_Homo sapiens_hsa043802.71878039
9Complement and coagulation cascades_Homo sapiens_hsa046102.71717644
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57679682
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56647218
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54639479
13B cell receptor signaling pathway_Homo sapiens_hsa046622.53868152
14Acute myeloid leukemia_Homo sapiens_hsa052212.49571526
15Fatty acid degradation_Homo sapiens_hsa000712.41885293
16Leishmaniasis_Homo sapiens_hsa051402.31097588
17Caffeine metabolism_Homo sapiens_hsa002322.29928763
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29803421
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23469980
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18552481
21Peroxisome_Homo sapiens_hsa041462.05001225
22Butanoate metabolism_Homo sapiens_hsa006502.03514646
23Chemical carcinogenesis_Homo sapiens_hsa052042.00055368
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98220165
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.96358392
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95741915
27Histidine metabolism_Homo sapiens_hsa003401.95630344
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.95180413
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.92315923
30Primary immunodeficiency_Homo sapiens_hsa053401.84524776
31PPAR signaling pathway_Homo sapiens_hsa033201.82401486
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.79755939
33Propanoate metabolism_Homo sapiens_hsa006401.79425957
34Malaria_Homo sapiens_hsa051441.78532004
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77475954
36Staphylococcus aureus infection_Homo sapiens_hsa051501.76524663
37Non-small cell lung cancer_Homo sapiens_hsa052231.74130686
38T cell receptor signaling pathway_Homo sapiens_hsa046601.72150016
39Retinol metabolism_Homo sapiens_hsa008301.71732676
40beta-Alanine metabolism_Homo sapiens_hsa004101.69812829
41Fatty acid metabolism_Homo sapiens_hsa012121.69636046
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68545110
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63886753
44Selenocompound metabolism_Homo sapiens_hsa004501.62134970
45Chronic myeloid leukemia_Homo sapiens_hsa052201.57979159
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.57911913
47Tuberculosis_Homo sapiens_hsa051521.57709238
48Phenylalanine metabolism_Homo sapiens_hsa003601.55943351
49Bile secretion_Homo sapiens_hsa049761.52586559
50Measles_Homo sapiens_hsa051621.48191948
51VEGF signaling pathway_Homo sapiens_hsa043701.48058960
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47067858
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45136843
54Tyrosine metabolism_Homo sapiens_hsa003501.41692859
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41468153
56Allograft rejection_Homo sapiens_hsa053301.40022181
57Influenza A_Homo sapiens_hsa051641.37907877
58Folate biosynthesis_Homo sapiens_hsa007901.37873198
59Sulfur metabolism_Homo sapiens_hsa009201.37258374
60Graft-versus-host disease_Homo sapiens_hsa053321.34229414
61Pyruvate metabolism_Homo sapiens_hsa006201.33899486
62Toxoplasmosis_Homo sapiens_hsa051451.33292614
63Starch and sucrose metabolism_Homo sapiens_hsa005001.32288273
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.31856054
65TNF signaling pathway_Homo sapiens_hsa046681.31680045
66ABC transporters_Homo sapiens_hsa020101.28667012
67Hematopoietic cell lineage_Homo sapiens_hsa046401.28023853
68Notch signaling pathway_Homo sapiens_hsa043301.26867527
69Chemokine signaling pathway_Homo sapiens_hsa040621.26335866
70Fat digestion and absorption_Homo sapiens_hsa049751.25786994
71NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25399991
72Jak-STAT signaling pathway_Homo sapiens_hsa046301.23976418
73Pancreatic cancer_Homo sapiens_hsa052121.23779032
74Autoimmune thyroid disease_Homo sapiens_hsa053201.23710573
75Herpes simplex infection_Homo sapiens_hsa051681.23301748
76Fatty acid elongation_Homo sapiens_hsa000621.21786573
77Steroid biosynthesis_Homo sapiens_hsa001001.18974140
78Hepatitis B_Homo sapiens_hsa051611.17006624
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15284245
80Biosynthesis of amino acids_Homo sapiens_hsa012301.14390454
81Maturity onset diabetes of the young_Homo sapiens_hsa049501.14042802
82Sulfur relay system_Homo sapiens_hsa041221.13187975
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13055943
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11485267
85Platelet activation_Homo sapiens_hsa046111.06960633
86Carbon metabolism_Homo sapiens_hsa012001.05247516
87Renal cell carcinoma_Homo sapiens_hsa052111.02031729
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01581943
89Neurotrophin signaling pathway_Homo sapiens_hsa047221.00883239
90Endometrial cancer_Homo sapiens_hsa052131.00494304
91Vitamin B6 metabolism_Homo sapiens_hsa007500.98873312
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.97915614
93mTOR signaling pathway_Homo sapiens_hsa041500.97543710
94Arginine and proline metabolism_Homo sapiens_hsa003300.96595070
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96167109
96Prolactin signaling pathway_Homo sapiens_hsa049170.95553028
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.95015215
98Type I diabetes mellitus_Homo sapiens_hsa049400.93666357
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91602083
100Apoptosis_Homo sapiens_hsa042100.90556484
101Lysosome_Homo sapiens_hsa041420.89281592
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88999181
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87808385
104Lysine degradation_Homo sapiens_hsa003100.87577224
105Choline metabolism in cancer_Homo sapiens_hsa052310.87529721
106Vitamin digestion and absorption_Homo sapiens_hsa049770.85639190
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85318125
108Antigen processing and presentation_Homo sapiens_hsa046120.85206517
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81467651
110One carbon pool by folate_Homo sapiens_hsa006700.80851446
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.78213569
112Inositol phosphate metabolism_Homo sapiens_hsa005620.76222209
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75280046
114Legionellosis_Homo sapiens_hsa051340.68339989
115FoxO signaling pathway_Homo sapiens_hsa040680.67823125
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67175383
117Glutathione metabolism_Homo sapiens_hsa004800.67156763
118Glycerolipid metabolism_Homo sapiens_hsa005610.66670157
119Viral myocarditis_Homo sapiens_hsa054160.66555176
120Phagosome_Homo sapiens_hsa041450.66330718
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.65497563
122Endocytosis_Homo sapiens_hsa041440.65199691
123GnRH signaling pathway_Homo sapiens_hsa049120.63922989
124Pentose phosphate pathway_Homo sapiens_hsa000300.63191420
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63167718
126Epstein-Barr virus infection_Homo sapiens_hsa051690.62683790
127Salmonella infection_Homo sapiens_hsa051320.61864389
128Bladder cancer_Homo sapiens_hsa052190.60972269
129Shigellosis_Homo sapiens_hsa051310.59907686
130HTLV-I infection_Homo sapiens_hsa051660.59266526
131Glioma_Homo sapiens_hsa052140.59069483
132Asthma_Homo sapiens_hsa053100.58913574
133ErbB signaling pathway_Homo sapiens_hsa040120.57559495
134HIF-1 signaling pathway_Homo sapiens_hsa040660.55047164
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54574670
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54458201
137Viral carcinogenesis_Homo sapiens_hsa052030.53992112
138Colorectal cancer_Homo sapiens_hsa052100.52018168
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51717300
140Amoebiasis_Homo sapiens_hsa051460.47756222
141MAPK signaling pathway_Homo sapiens_hsa040100.47014146
142Fatty acid biosynthesis_Homo sapiens_hsa000610.46934054
143Dorso-ventral axis formation_Homo sapiens_hsa043200.45852168
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45481167
145Metabolic pathways_Homo sapiens_hsa011000.44408592
146Galactose metabolism_Homo sapiens_hsa000520.34584206
147Prion diseases_Homo sapiens_hsa050200.33882063
148Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33566462
149Fructose and mannose metabolism_Homo sapiens_hsa000510.26421254
150Insulin resistance_Homo sapiens_hsa049310.24882117
151Linoleic acid metabolism_Homo sapiens_hsa005910.24550547
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.23862747
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19613028
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.17064552
155Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10966906
156Glucagon signaling pathway_Homo sapiens_hsa049220.06942221
157Systemic lupus erythematosus_Homo sapiens_hsa053220.02833080
158AMPK signaling pathway_Homo sapiens_hsa041520.01591705
159Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2338551
160Pertussis_Homo sapiens_hsa05133-0.2330356
161Type II diabetes mellitus_Homo sapiens_hsa04930-0.2310423
162Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.2170062
163Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2074093
164Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2004391
165Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1960213
166Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1854545
167Regulation of autophagy_Homo sapiens_hsa04140-0.1526769
168Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1443767
169Hepatitis C_Homo sapiens_hsa05160-0.1313894
170Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1145450
171RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1112826
172Insulin signaling pathway_Homo sapiens_hsa04910-0.1081320
173African trypanosomiasis_Homo sapiens_hsa05143-0.1019621
174Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0892997
175Renin-angiotensin system_Homo sapiens_hsa04614-0.0868076
176Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0824723
177Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0800522
178Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0691938

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