TMEM87A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)5.33813453
2short-term memory (GO:0007614)5.23642679
3negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)5.15495891
4presynaptic membrane assembly (GO:0097105)4.98447071
5positive regulation of protein kinase C signaling (GO:0090037)4.63792237
6negative regulation of execution phase of apoptosis (GO:1900118)4.60006421
7omega-hydroxylase P450 pathway (GO:0097267)4.54891423
8daunorubicin metabolic process (GO:0044597)4.31187676
9polyketide metabolic process (GO:0030638)4.31187676
10doxorubicin metabolic process (GO:0044598)4.31187676
11regulation of pigment cell differentiation (GO:0050932)4.14320107
12presynaptic membrane organization (GO:0097090)4.10526658
13postsynaptic membrane organization (GO:0001941)3.91095011
14positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.85267507
15regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.85267507
16cullin deneddylation (GO:0010388)3.82973208
17central nervous system myelination (GO:0022010)3.72637142
18axon ensheathment in central nervous system (GO:0032291)3.72637142
19regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.71700212
20DNA double-strand break processing (GO:0000729)3.58334173
21positive regulation of protein autophosphorylation (GO:0031954)3.56574151
22protein deneddylation (GO:0000338)3.49638331
23eyelid development in camera-type eye (GO:0061029)3.49492921
24lipid particle organization (GO:0034389)3.47654458
25ribosomal small subunit biogenesis (GO:0042274)3.41772027
26negative regulation of epidermis development (GO:0045683)3.37129361
27negative regulation of keratinocyte proliferation (GO:0010839)3.36291690
28regulation of protein glycosylation (GO:0060049)3.35379851
29response to pheromone (GO:0019236)3.31883289
30protein K11-linked deubiquitination (GO:0035871)3.29901739
31negative regulation of neurological system process (GO:0031645)3.29442800
32melanin metabolic process (GO:0006582)3.28245657
33negative regulation of JUN kinase activity (GO:0043508)3.27534878
34spermatid nucleus differentiation (GO:0007289)3.26936099
35GMP metabolic process (GO:0046037)3.24219826
36UDP-N-acetylglucosamine metabolic process (GO:0006047)3.24122199
37maintenance of protein location in nucleus (GO:0051457)3.23598376
38phenol-containing compound catabolic process (GO:0019336)3.23426984
39piRNA metabolic process (GO:0034587)3.22886952
40regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.22231581
41DNA damage response, detection of DNA damage (GO:0042769)3.20500373
42regulation of development, heterochronic (GO:0040034)3.19484264
43interkinetic nuclear migration (GO:0022027)3.16687297
44ribosome assembly (GO:0042255)3.15097136
45keratinocyte proliferation (GO:0043616)3.14754860
46negative regulation of metanephros development (GO:0072217)3.14640369
47protein prenylation (GO:0018342)3.13064776
48prenylation (GO:0097354)3.13064776
49negative regulation of epidermal cell differentiation (GO:0045605)3.12887528
50somite rostral/caudal axis specification (GO:0032525)3.11963251
51organ growth (GO:0035265)3.11675804
52limb bud formation (GO:0060174)3.06423361
53protein heterotetramerization (GO:0051290)3.05123097
54membrane budding (GO:0006900)3.04586875
55regulation of timing of cell differentiation (GO:0048505)3.04178620
56endothelium development (GO:0003158)3.04055595
57cilium morphogenesis (GO:0060271)3.03942015
58water-soluble vitamin biosynthetic process (GO:0042364)3.00664757
59forebrain neuron differentiation (GO:0021879)3.00440014
60negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.98445629
61melanin biosynthetic process (GO:0042438)2.98074466
62facial nerve structural organization (GO:0021612)2.97208940
63regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.95644316
64intestinal epithelial cell development (GO:0060576)2.95088000
65fibroblast migration (GO:0010761)2.94727588
66lactate metabolic process (GO:0006089)2.94101634
67regulation of podosome assembly (GO:0071801)2.93047714
68regulation of transforming growth factor beta2 production (GO:0032909)2.92417390
69regulation of nuclear cell cycle DNA replication (GO:0033262)2.91668944
70keratan sulfate catabolic process (GO:0042340)2.89540022
71anterior/posterior axis specification, embryo (GO:0008595)2.87725115
72regulation of cellular amino acid metabolic process (GO:0006521)2.87497239
73muscle organ morphogenesis (GO:0048644)2.87025357
74transcription elongation from RNA polymerase I promoter (GO:0006362)2.85986682
75negative regulation of Ras GTPase activity (GO:0034261)2.85092743
76lateral sprouting from an epithelium (GO:0060601)2.84452531
77intraciliary transport (GO:0042073)2.82499706
78cell fate commitment involved in formation of primary germ layer (GO:0060795)2.82368927
79iron ion import (GO:0097286)2.82364783
80desmosome organization (GO:0002934)2.82139776
81magnesium ion transport (GO:0015693)2.82059088
82branching involved in mammary gland duct morphogenesis (GO:0060444)2.81998521
83nucleotide-sugar biosynthetic process (GO:0009226)2.80579342
84glycerol ether metabolic process (GO:0006662)2.80083019
85regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.79332548
86retinal cone cell development (GO:0046549)2.79081708
87cranial nerve morphogenesis (GO:0021602)2.78831546
88dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.78514210
89nucleotide transmembrane transport (GO:1901679)2.77752267
90platelet dense granule organization (GO:0060155)2.73874272
91oligodendrocyte differentiation (GO:0048709)2.73699442
92centriole replication (GO:0007099)2.73258530
93retina layer formation (GO:0010842)2.71592835
94bone trabecula formation (GO:0060346)2.70684908
95mesonephros development (GO:0001823)2.69904654
96regulation of MHC class I biosynthetic process (GO:0045343)2.69162702
97proteasome assembly (GO:0043248)2.69056621
98ether lipid metabolic process (GO:0046485)2.68500465
99response to dietary excess (GO:0002021)2.68284550
100ER overload response (GO:0006983)2.67841639
101interferon-gamma production (GO:0032609)2.67797816
102sphingoid metabolic process (GO:0046519)2.67515528
103regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.66849009
104retinal metabolic process (GO:0042574)2.66813388
105ventricular system development (GO:0021591)2.65695827
106mesenchymal cell differentiation involved in kidney development (GO:0072161)2.65481989
107mesenchymal cell differentiation involved in renal system development (GO:2001012)2.65481989
108aminoglycoside antibiotic metabolic process (GO:0030647)2.65302058
109regulation of meiosis I (GO:0060631)2.63669526
110cranial nerve structural organization (GO:0021604)2.63123163
111metanephric nephron tubule development (GO:0072234)2.61107593
112metanephric tubule development (GO:0072170)2.61107593
113response to redox state (GO:0051775)2.58957245
114spinal cord motor neuron differentiation (GO:0021522)2.58402513
115positive regulation of glycoprotein biosynthetic process (GO:0010560)2.58031214
116DNA methylation involved in gamete generation (GO:0043046)2.56763775
117COPII vesicle coating (GO:0048208)2.56029288
118sympathetic nervous system development (GO:0048485)2.56009308
119rRNA methylation (GO:0031167)2.55764854
120regulation of protein kinase C signaling (GO:0090036)2.55471985
121ether metabolic process (GO:0018904)2.55003578
122neuronal action potential propagation (GO:0019227)2.54377461
123respiratory chain complex IV assembly (GO:0008535)2.53837174
124regulation of cilium movement (GO:0003352)2.53834545
125regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.53650580
126head development (GO:0060322)2.53528982
127regulation of keratinocyte proliferation (GO:0010837)2.52941989
128female gonad development (GO:0008585)2.50711162
129fatty acid elongation (GO:0030497)2.50352350
130regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.50179543
131branched-chain amino acid catabolic process (GO:0009083)2.49342653
132keratinocyte development (GO:0003334)2.48938203
133regulation of execution phase of apoptosis (GO:1900117)2.48355481
134negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.47814626
135positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47733943
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.47608919
137negative regulation of activin receptor signaling pathway (GO:0032926)2.47234175
138nephron epithelium development (GO:0072009)2.47211235
139axoneme assembly (GO:0035082)2.45473072
140genitalia morphogenesis (GO:0035112)2.44891085
141bundle of His cell to Purkinje myocyte communication (GO:0086069)2.44834088
142smooth muscle tissue development (GO:0048745)2.44816690
143auditory receptor cell differentiation (GO:0042491)2.44442623
144branch elongation of an epithelium (GO:0060602)2.44304290
145primitive streak formation (GO:0090009)2.44267988
146regulation of non-canonical Wnt signaling pathway (GO:2000050)2.43961332
147positive regulation of steroid hormone secretion (GO:2000833)2.42927878
148negative regulation of complement activation (GO:0045916)2.42399099
149epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42052870
150termination of RNA polymerase I transcription (GO:0006363)2.42018167
151histone H4-K12 acetylation (GO:0043983)2.41824781
152regulation of vitamin D biosynthetic process (GO:0060556)2.41824532
153developmental pigmentation (GO:0048066)2.41285136
154metaphase plate congression (GO:0051310)2.39860835
155branching involved in labyrinthine layer morphogenesis (GO:0060670)2.39797254
156pattern specification involved in kidney development (GO:0061004)2.39740873
157Leydig cell differentiation (GO:0033327)2.39696335
158signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.39634603
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.39634603
160regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.39514268
161signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.39509280
162signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.39509280
163signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.39509280
164regulation of mammary gland epithelial cell proliferation (GO:0033599)2.39389467
165metanephric epithelium development (GO:0072207)2.38816826
166response to X-ray (GO:0010165)2.38408089
167cellular response to zinc ion (GO:0071294)2.38404810
168DNA ligation (GO:0006266)2.37447489
169secondary metabolite biosynthetic process (GO:0044550)2.37011262
170metanephric nephron epithelium development (GO:0072243)2.36744566
171regulation of response to osmotic stress (GO:0047484)2.36639935
172endocrine hormone secretion (GO:0060986)2.36238654
173response to folic acid (GO:0051593)2.34581333
174zinc ion transport (GO:0006829)2.32824516
175regulation of somitogenesis (GO:0014807)2.32005543
176cornea development in camera-type eye (GO:0061303)2.31839899
177regulation of keratinocyte differentiation (GO:0045616)2.31812666
178hemidesmosome assembly (GO:0031581)2.31618139
179regulation of protein autophosphorylation (GO:0031952)2.31316589
180regulation of transcription involved in cell fate commitment (GO:0060850)2.31310568
181regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.31183690
182regulation of histone H3-K4 methylation (GO:0051569)2.30807349
183positive regulation of organelle assembly (GO:1902117)2.29713651
184C-terminal protein lipidation (GO:0006501)2.29481712
185negative regulation of acute inflammatory response (GO:0002674)2.29347513
186surfactant homeostasis (GO:0043129)2.29075960
187regulation of apoptotic process involved in morphogenesis (GO:1902337)2.28473101
188photoreceptor cell maintenance (GO:0045494)2.27219509
189centriole assembly (GO:0098534)2.26614390
190mRNA modification (GO:0016556)2.25086604
191notochord development (GO:0030903)2.24112993
192regulation of cytokine production involved in inflammatory response (GO:1900015)2.23093011
193nonmotile primary cilium assembly (GO:0035058)2.21761005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.94463715
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.94463715
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.94463715
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.32203687
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.19702650
6EZH2_22144423_ChIP-Seq_EOC_Human4.00415183
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.06534089
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.88293076
9* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73021462
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.58943128
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.56729767
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.55559341
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51128787
14ELK1_19687146_ChIP-ChIP_HELA_Human2.49831384
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.45613517
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.44148940
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.40308630
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32892511
19RNF2_27304074_Chip-Seq_NSC_Mouse2.25838522
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.24249838
21IRF1_19129219_ChIP-ChIP_H3396_Human2.21736534
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.17097533
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.08676302
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.07301050
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06911288
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04269486
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98623250
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98592923
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.95858343
30GBX2_23144817_ChIP-Seq_PC3_Human1.92200906
31ZNF274_21170338_ChIP-Seq_K562_Hela1.85978490
32VDR_22108803_ChIP-Seq_LS180_Human1.84776787
33EWS_26573619_Chip-Seq_HEK293_Human1.80188848
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78973960
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78973960
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.77803713
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77270294
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74470687
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74412928
40IGF1R_20145208_ChIP-Seq_DFB_Human1.74267954
41TCF3_18692474_ChIP-Seq_MESCs_Mouse1.72453940
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.71123165
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70354940
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.70179909
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66454576
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66127155
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64948084
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63162172
49AR_21572438_ChIP-Seq_LNCaP_Human1.62696152
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61001562
51TAF15_26573619_Chip-Seq_HEK293_Human1.60020044
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57767910
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56860794
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54290134
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53261574
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50956751
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50564965
58CDX2_22108803_ChIP-Seq_LS180_Human1.48432755
59AR_21909140_ChIP-Seq_LNCAP_Human1.48402976
60SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.47182452
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.47101576
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46893180
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46310185
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45221721
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.44979578
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44916532
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44162525
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.42968335
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42919692
70CJUN_26792858_Chip-Seq_BT549_Human1.39116501
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.38892256
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.37940579
73SMAD4_21799915_ChIP-Seq_A2780_Human1.35213832
74* ESR1_20079471_ChIP-ChIP_T-47D_Human1.34541738
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.34044419
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33636454
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.33563371
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32732598
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32417595
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31911008
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31488103
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.31207694
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30672282
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30470244
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30470244
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.30345208
87* E2F1_18555785_Chip-Seq_ESCs_Mouse1.27857181
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27826098
89ER_23166858_ChIP-Seq_MCF-7_Human1.27619797
90* P300_18555785_Chip-Seq_ESCs_Mouse1.27050579
91* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25827794
92FUS_26573619_Chip-Seq_HEK293_Human1.24884987
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24600540
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24363911
95BCAT_22108803_ChIP-Seq_LS180_Human1.24299617
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23072394
97* NMYC_18555785_Chip-Seq_ESCs_Mouse1.22326725
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22069785
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21623723
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21409575
101RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21385945
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.21074787
103* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20639873
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19520092
105* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19418355
106VDR_23849224_ChIP-Seq_CD4+_Human1.19282716
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18487101
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17729804
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.15725616
110OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15355653
111* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15140863
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13697769
113CBP_20019798_ChIP-Seq_JUKART_Human1.13697769
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13330510
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.13238940
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.12794174
117TCF4_22108803_ChIP-Seq_LS180_Human1.12332804
118TP63_23658742_ChIP-Seq_EP156T_Human1.12156889
119TP53_18474530_ChIP-ChIP_U2OS_Human1.11617722
120SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10704808
121CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10501823
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10413140
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10239540
124AR_25329375_ChIP-Seq_VCAP_Human1.09890143
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09524048
126TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.09289677
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08954026
128BRD4_25478319_ChIP-Seq_HGPS_Human1.07986370
129* ZFX_18555785_Chip-Seq_ESCs_Mouse1.07887786
130IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07034655
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06515486
132STAT3_23295773_ChIP-Seq_U87_Human1.06472914
133P53_22387025_ChIP-Seq_ESCs_Mouse1.05989950
134* OCT4_18555785_Chip-Seq_ESCs_Mouse1.05296345
135* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05102547
136NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04139860
137ELF5_23300383_ChIP-Seq_T47D_Human1.03246840
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02188067
139* SOX2_18555785_Chip-Seq_ESCs_Mouse1.01912002
140EZH2_27294783_Chip-Seq_NPCs_Mouse1.01596681
141CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01595351
142* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01227152
143SMAD_19615063_ChIP-ChIP_OVARY_Human1.00912943
144KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00910823
145* KLF4_18555785_Chip-Seq_ESCs_Mouse1.00376119
146NOTCH1_21737748_ChIP-Seq_TLL_Human1.00287563
147TP53_20018659_ChIP-ChIP_R1E_Mouse1.00238488
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00057219
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.99503954
150POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98381071
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98381071
152* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97214619
153SOX2_16153702_ChIP-ChIP_HESCs_Human0.95442569
154* CTCF_18555785_Chip-Seq_ESCs_Mouse0.94746885
155CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94697710
156SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94083380
157P300_19829295_ChIP-Seq_ESCs_Human0.94026136
158STAT3_18555785_ChIP-Seq_MESCs_Mouse0.91263818
159AHR_22903824_ChIP-Seq_MCF-7_Human0.88441170
160RING1B_27294783_Chip-Seq_ESCs_Mouse0.87621704
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.87537915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.07273754
2MP0004381_abnormal_hair_follicle4.58800525
3MP0005409_darkened_coat_color4.56633740
4MP0006292_abnormal_olfactory_placode4.55158967
5MP0001188_hyperpigmentation4.43044197
6MP0009379_abnormal_foot_pigmentation3.41996131
7MP0003950_abnormal_plasma_membrane3.33615665
8MP0010234_abnormal_vibrissa_follicle3.33470122
9MP0005275_abnormal_skin_tensile2.84212108
10MP0009780_abnormal_chondrocyte_physiolo2.73287375
11MP0003315_abnormal_perineum_morphology2.63596054
12MP0003011_delayed_dark_adaptation2.54088815
13MP0004782_abnormal_surfactant_physiolog2.48784728
14MP0002277_abnormal_respiratory_mucosa2.45632575
15MP0003938_abnormal_ear_development2.39933469
16MP0003195_calcinosis2.35934464
17MP0005257_abnormal_intraocular_pressure2.33855435
18MP0000015_abnormal_ear_pigmentation2.22509212
19MP0006054_spinal_hemorrhage2.13879729
20MP0005174_abnormal_tail_pigmentation2.06609187
21MP0000427_abnormal_hair_cycle2.06226561
22MP0005408_hypopigmentation2.02391339
23MP0005394_taste/olfaction_phenotype1.89912954
24MP0005499_abnormal_olfactory_system1.89912954
25MP0002254_reproductive_system_inflammat1.88435057
26MP0000566_synostosis1.87582512
27MP0008877_abnormal_DNA_methylation1.80916899
28MP0002102_abnormal_ear_morphology1.79781782
29MP0000049_abnormal_middle_ear1.78588059
30MP0001984_abnormal_olfaction1.77365270
31MP0003937_abnormal_limbs/digits/tail_de1.76723910
32MP0005075_abnormal_melanosome_morpholog1.75455554
33MP0003186_abnormal_redox_activity1.72229781
34MP0002177_abnormal_outer_ear1.68046241
35MP0005367_renal/urinary_system_phenotyp1.67404533
36MP0000516_abnormal_urinary_system1.67404533
37MP0001958_emphysema1.66464329
38MP0003880_abnormal_central_pattern1.66384096
39MP0002060_abnormal_skin_morphology1.57996200
40MP0010307_abnormal_tumor_latency1.52251026
41MP0002249_abnormal_larynx_morphology1.50906274
42MP0004742_abnormal_vestibular_system1.49118036
43MP0009250_abnormal_appendicular_skeleto1.48262333
44MP0003724_increased_susceptibility_to1.45276786
45MP0002876_abnormal_thyroid_physiology1.44294232
46MP0002796_impaired_skin_barrier1.43320439
47MP0005164_abnormal_response_to1.41688707
48MP0000627_abnormal_mammary_gland1.41648642
49MP0002751_abnormal_autonomic_nervous1.40762525
50MP0000762_abnormal_tongue_morphology1.40551962
51MP0001216_abnormal_epidermal_layer1.38256350
52MP0003806_abnormal_nucleotide_metabolis1.36135771
53MP0003183_abnormal_peptide_metabolism1.35968268
54MP0008875_abnormal_xenobiotic_pharmacok1.35491246
55MP0010368_abnormal_lymphatic_system1.35342567
56MP0008058_abnormal_DNA_repair1.35150383
57MP0008789_abnormal_olfactory_epithelium1.34201397
58MP0002090_abnormal_vision1.33603039
59MP0008438_abnormal_cutaneous_collagen1.31494781
60MP0002009_preneoplasia1.30551299
61MP0003890_abnormal_embryonic-extraembry1.28976629
62MP0005501_abnormal_skin_physiology1.28083117
63MP0005395_other_phenotype1.26939634
64MP0003755_abnormal_palate_morphology1.24228085
65MP0005647_abnormal_sex_gland1.20811152
66MP0000432_abnormal_head_morphology1.19556049
67MP0010771_integument_phenotype1.19035495
68MP0003303_peritoneal_inflammation1.17947130
69MP0002098_abnormal_vibrissa_morphology1.17711944
70MP0001177_atelectasis1.16365176
71MP0000428_abnormal_craniofacial_morphol1.16102898
72MP0003935_abnormal_craniofacial_develop1.15786469
73MP0010352_gastrointestinal_tract_polyps1.15441282
74MP0000026_abnormal_inner_ear1.12518047
75MP0001486_abnormal_startle_reflex1.12513392
76MP0000383_abnormal_hair_follicle1.11593783
77MP0001286_abnormal_eye_development1.10043856
78MP0001881_abnormal_mammary_gland1.09933656
79MP0005171_absent_coat_pigmentation1.08725455
80MP0002233_abnormal_nose_morphology1.08066669
81MP0000613_abnormal_salivary_gland1.07188296
82MP0002095_abnormal_skin_pigmentation1.07002877
83MP0001879_abnormal_lymphatic_vessel1.06391302
84MP0000631_abnormal_neuroendocrine_gland1.05364501
85MP0001346_abnormal_lacrimal_gland1.04360193
86MP0009384_cardiac_valve_regurgitation1.02415214
87MP0003941_abnormal_skin_development1.00031542
88MP0003936_abnormal_reproductive_system1.00005337
89MP0001542_abnormal_bone_strength0.98947277
90MP0005646_abnormal_pituitary_gland0.98342873
91MP0002133_abnormal_respiratory_system0.98077198
92MP0005388_respiratory_system_phenotype0.98077198
93MP0004957_abnormal_blastocyst_morpholog0.96449076
94MP0003828_pulmonary_edema0.95115310
95MP0004142_abnormal_muscle_tone0.93258953
96MP0002752_abnormal_somatic_nervous0.93005635
97MP0000579_abnormal_nail_morphology0.92797432
98MP0000372_irregular_coat_pigmentation0.92743806
99MP0002295_abnormal_pulmonary_circulatio0.92360416
100MP0010094_abnormal_chromosome_stability0.92033494
101MP0005503_abnormal_tendon_morphology0.91691408
102MP0000467_abnormal_esophagus_morphology0.91452450
103MP0000778_abnormal_nervous_system0.90085329
104MP0000678_abnormal_parathyroid_gland0.89720720
105MP0002160_abnormal_reproductive_system0.88907247
106MP0006072_abnormal_retinal_apoptosis0.88895476
107MP0002168_other_aberrant_phenotype0.88774334
108MP0001919_abnormal_reproductive_system0.88690648
109MP0001986_abnormal_taste_sensitivity0.87838113
110MP0003656_abnormal_erythrocyte_physiolo0.87675000
111MP0006082_CNS_inflammation0.86416000
112MP0003693_abnormal_embryo_hatching0.86223139
113MP0001340_abnormal_eyelid_morphology0.84770363
114MP0001191_abnormal_skin_condition0.84472247
115MP0002938_white_spotting0.84033284
116MP0002116_abnormal_craniofacial_bone0.83632911
117MP0002332_abnormal_exercise_endurance0.82954773
118MP0001243_abnormal_dermal_layer0.82828064
119MP0004145_abnormal_muscle_electrophysio0.82523219
120MP0001873_stomach_inflammation0.82433189
121MP0004272_abnormal_basement_membrane0.81189449
122MP0002114_abnormal_axial_skeleton0.80417305
123MP0001764_abnormal_homeostasis0.80294114
124MP0005248_abnormal_Harderian_gland0.80292494
125MP0003943_abnormal_hepatobiliary_system0.79739530
126MP0008260_abnormal_autophagy0.78962492
127MP0003718_maternal_effect0.78571847
128MP0001963_abnormal_hearing_physiology0.77735118
129MP0005391_vision/eye_phenotype0.77729556
130MP0005253_abnormal_eye_physiology0.77080435
131MP0004215_abnormal_myocardial_fiber0.76447574
132MP0008057_abnormal_DNA_replication0.76427992
133MP0003385_abnormal_body_wall0.76263487
134MP0002092_abnormal_eye_morphology0.75325977
135MP0002148_abnormal_hypersensitivity_rea0.75035815
136MP0002166_altered_tumor_susceptibility0.74886610
137MP0008995_early_reproductive_senescence0.74529823
138MP0000569_abnormal_digit_pigmentation0.74365280
139MP0005195_abnormal_posterior_eye0.74240150
140MP0002932_abnormal_joint_morphology0.72584087
141MP0003122_maternal_imprinting0.71609470
142MP0004043_abnormal_pH_regulation0.71172116
143MP0005551_abnormal_eye_electrophysiolog0.70026495
144MP0001853_heart_inflammation0.69636284
145MP0000647_abnormal_sebaceous_gland0.68924332
146MP0005197_abnormal_uvea_morphology0.68509742
147MP0003121_genomic_imprinting0.65003824
148MP0000920_abnormal_myelination0.64037426
149MP0002067_abnormal_sensory_capabilities0.61981490
150MP0000858_altered_metastatic_potential0.59757163
151MP0004264_abnormal_extraembryonic_tissu0.59176993
152MP0002111_abnormal_tail_morphology0.59085934
153MP0002081_perinatal_lethality0.59055456
154MP0002282_abnormal_trachea_morphology0.57735331
155MP0003861_abnormal_nervous_system0.57451699
156MP0010678_abnormal_skin_adnexa0.56119140
157MP0000377_abnormal_hair_follicle0.54628815
158MP0002638_abnormal_pupillary_reflex0.54063136
159MP0004133_heterotaxia0.53797548
160MP0003786_premature_aging0.53410073
161MP0001293_anophthalmia0.53336679
162MP0002109_abnormal_limb_morphology0.53247050

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of anterior horn cells (HP:0002398)4.65472283
2Abnormality of the anterior horn cell (HP:0006802)4.65472283
3Sex reversal (HP:0012245)4.45683510
4Abnormal sex determination (HP:0012244)4.45683510
5Abnormality of secondary sexual hair (HP:0009888)3.88562569
6Abnormality of the axillary hair (HP:0100134)3.88562569
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.65989458
8Bilateral microphthalmos (HP:0007633)3.40261166
9Anomalous pulmonary venous return (HP:0010772)3.32117605
10Abnormality of the pulmonary veins (HP:0011718)3.19998375
11Chromsome breakage (HP:0040012)3.19141157
12Right ventricular cardiomyopathy (HP:0011663)3.17074412
13Supernumerary spleens (HP:0009799)3.15402798
14Sensory axonal neuropathy (HP:0003390)3.13168850
15Concave nail (HP:0001598)3.05963893
16Nasolacrimal duct obstruction (HP:0000579)3.05285087
17True hermaphroditism (HP:0010459)2.99563508
18Bile duct proliferation (HP:0001408)2.82161038
19Abnormal biliary tract physiology (HP:0012439)2.82161038
20Partial duplication of thumb phalanx (HP:0009944)2.78238258
21Testicular atrophy (HP:0000029)2.77359050
22Rhinitis (HP:0012384)2.72825954
23Patchy hypopigmentation of hair (HP:0011365)2.69507148
24Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67508102
25Oral leukoplakia (HP:0002745)2.67389874
26Aplasia/Hypoplasia of the fovea (HP:0008060)2.64365728
27Hypoplasia of the fovea (HP:0007750)2.64365728
28Abnormality of the phalanges of the hallux (HP:0010057)2.62949347
29Septo-optic dysplasia (HP:0100842)2.62141454
30Partial duplication of the phalanx of hand (HP:0009999)2.59709296
31Pancreatic cysts (HP:0001737)2.56416935
32Medial flaring of the eyebrow (HP:0010747)2.53767922
33Chronic bronchitis (HP:0004469)2.52040623
34Abnormality of the lacrimal duct (HP:0011481)2.49093072
35Metaphyseal dysplasia (HP:0100255)2.49032746
36Nephroblastoma (Wilms tumor) (HP:0002667)2.47021883
37Rib fusion (HP:0000902)2.46823702
38Abnormal lung lobation (HP:0002101)2.44203477
39Abnormality of the septum pellucidum (HP:0007375)2.42264355
40Congenital, generalized hypertrichosis (HP:0004540)2.42242164
41Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.41813342
42Hypochromic microcytic anemia (HP:0004840)2.41117837
43Curly hair (HP:0002212)2.40953597
44Adrenal hypoplasia (HP:0000835)2.40491005
45Atelectasis (HP:0100750)2.39416680
46Alopecia of scalp (HP:0002293)2.36709637
47Abnormality of the nasolacrimal system (HP:0000614)2.36200225
48Pancreatic fibrosis (HP:0100732)2.36164710
49Absent septum pellucidum (HP:0001331)2.35391153
50Posterior subcapsular cataract (HP:0007787)2.34064757
51Duplication of thumb phalanx (HP:0009942)2.32169429
52Embryonal renal neoplasm (HP:0011794)2.30551352
53Attenuation of retinal blood vessels (HP:0007843)2.28744277
54Dyschromatopsia (HP:0007641)2.28652065
55Congenital sensorineural hearing impairment (HP:0008527)2.27354969
56Large for gestational age (HP:0001520)2.26508840
57Optic nerve hypoplasia (HP:0000609)2.25079847
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24515639
59Abnormal protein N-linked glycosylation (HP:0012347)2.24515639
60Abnormal protein glycosylation (HP:0012346)2.24515639
61Abnormal glycosylation (HP:0012345)2.24515639
62Agammaglobulinemia (HP:0004432)2.24384182
63Abnormal ciliary motility (HP:0012262)2.23416392
64Meckel diverticulum (HP:0002245)2.21382127
65Parakeratosis (HP:0001036)2.21312105
66Impulsivity (HP:0100710)2.19838706
67Abnormality of methionine metabolism (HP:0010901)2.19104520
68Gaze-evoked nystagmus (HP:0000640)2.17713965
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.17100913
70Obstructive sleep apnea (HP:0002870)2.15777514
71Aplasia/Hypoplasia of the tongue (HP:0010295)2.15667781
72Molar tooth sign on MRI (HP:0002419)2.15207188
73Abnormality of midbrain morphology (HP:0002418)2.15207188
74Median cleft lip (HP:0000161)2.14967708
75Absent speech (HP:0001344)2.14888976
76Plantar hyperkeratosis (HP:0007556)2.14262662
77Upper limb muscle weakness (HP:0003484)2.12823528
78Intrahepatic cholestasis (HP:0001406)2.12267544
79Gonadotropin excess (HP:0000837)2.11435471
80Onycholysis (HP:0001806)2.09296153
81Abnormality of macular pigmentation (HP:0008002)2.08631141
82Duplicated collecting system (HP:0000081)2.07294625
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06929121
84Abnormality of the pons (HP:0007361)2.04848326
85Hyperactive renin-angiotensin system (HP:0000841)2.04560756
86Febrile seizures (HP:0002373)2.04493379
87Stenosis of the external auditory canal (HP:0000402)2.04336493
88White forelock (HP:0002211)2.04277691
89Congenital primary aphakia (HP:0007707)2.04182373
90Type I transferrin isoform profile (HP:0003642)2.03626436
91Abnormal hemoglobin (HP:0011902)2.02396951
92Progressive external ophthalmoplegia (HP:0000590)2.01406658
93Fair hair (HP:0002286)2.01355671
94Laryngomalacia (HP:0001601)2.01237697
95Woolly hair (HP:0002224)2.00877634
96Impaired proprioception (HP:0010831)2.00242580
97Reduced antithrombin III activity (HP:0001976)1.99803548
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98942214
99Aplasia cutis congenita (HP:0001057)1.98918397
100Palmar hyperkeratosis (HP:0010765)1.98187978
101Abnormality of the renal collecting system (HP:0004742)1.97329269
102Abnormality of the ileum (HP:0001549)1.96631954
103Palmoplantar hyperkeratosis (HP:0000972)1.96328743
104Tubulointerstitial nephritis (HP:0001970)1.95964039
105Sparse eyelashes (HP:0000653)1.95879111
106Anencephaly (HP:0002323)1.95124153
107Supernumerary ribs (HP:0005815)1.95053305
108Periauricular skin pits (HP:0100277)1.94624546
109Preauricular pit (HP:0004467)1.94624546
110Nephrogenic diabetes insipidus (HP:0009806)1.94206165
111Renal cortical cysts (HP:0000803)1.94071901
112Furrowed tongue (HP:0000221)1.93384114
113Triphalangeal thumb (HP:0001199)1.93019348
114Split foot (HP:0001839)1.92355706
115Aplasia/hypoplasia of the uterus (HP:0008684)1.92141732
116Thyroid-stimulating hormone excess (HP:0002925)1.90865974
117Abnormality of the fovea (HP:0000493)1.90251128
118Disproportionate short-trunk short stature (HP:0003521)1.89962886
119Abolished electroretinogram (ERG) (HP:0000550)1.89352834
120Thick nail (HP:0001805)1.89163195
121Supernumerary bones of the axial skeleton (HP:0009144)1.89128166
122Alacrima (HP:0000522)1.89111831
123Nonprogressive disorder (HP:0003680)1.88432029
124Genital tract atresia (HP:0001827)1.88344700
125Osteomalacia (HP:0002749)1.88034807
126Large earlobe (HP:0009748)1.87452969
127Male pseudohermaphroditism (HP:0000037)1.87323952
128Papillary thyroid carcinoma (HP:0002895)1.86962848
129Amniotic constriction ring (HP:0009775)1.86877237
130Abnormality of placental membranes (HP:0011409)1.86877237
131Lip pit (HP:0100267)1.86871419
132Abnormality of the renal medulla (HP:0100957)1.85565246
133Hypoplastic labia majora (HP:0000059)1.84608934
134Bronchiectasis (HP:0002110)1.84218738
135Follicular hyperkeratosis (HP:0007502)1.83795332
136Absent/shortened dynein arms (HP:0200106)1.83629636
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.83629636
138Breast carcinoma (HP:0003002)1.82984906
139Abnormality of the renal cortex (HP:0011035)1.82730946
140Hypokinesia (HP:0002375)1.82147059
141Seborrheic dermatitis (HP:0001051)1.81943758
142Abnormal respiratory motile cilium physiology (HP:0012261)1.81672954
143Azoospermia (HP:0000027)1.80944828
144Atrophy/Degeneration involving motor neurons (HP:0007373)1.80219474
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.79510686
146Pili torti (HP:0003777)1.79176032
147Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78463484
148Overfolded helix (HP:0000396)1.77951433
149Generalized hypopigmentation of hair (HP:0011358)1.76856687
150Gait imbalance (HP:0002141)1.76166509
151Methylmalonic acidemia (HP:0002912)1.75694061
152Vaginal atresia (HP:0000148)1.75357303
153Short tibia (HP:0005736)1.74833658
154Submucous cleft hard palate (HP:0000176)1.74394153
155Fused cervical vertebrae (HP:0002949)1.72880346
156Widely spaced teeth (HP:0000687)1.72735658
157Midline defect of the nose (HP:0004122)1.72664827
158Nephronophthisis (HP:0000090)1.72200605
159Renal salt wasting (HP:0000127)1.71641524
160Prostate neoplasm (HP:0100787)1.71333510
161Chin dimple (HP:0010751)1.71112453
162Abnormality of nail color (HP:0100643)1.70532527
163Fibular aplasia (HP:0002990)1.70512322
164Milia (HP:0001056)1.69827629
165Peripheral hypomyelination (HP:0007182)1.68981293
166Microvesicular hepatic steatosis (HP:0001414)1.67750640
167Aplastic anemia (HP:0001915)1.66914099
168Entropion (HP:0000621)1.66866076
169Abnormality of the preputium (HP:0100587)1.66208487
170Horizontal nystagmus (HP:0000666)1.66024120
171Upper motor neuron abnormality (HP:0002127)1.65819116
172Aplasia/Hypoplasia of the tibia (HP:0005772)1.65777744
1733-Methylglutaconic aciduria (HP:0003535)1.65197116
174Abnormal respiratory epithelium morphology (HP:0012253)1.65165779
175Abnormal respiratory motile cilium morphology (HP:0005938)1.65165779
176Oculomotor apraxia (HP:0000657)1.64666223
177Ulnar claw (HP:0001178)1.64045609
178Rectovaginal fistula (HP:0000143)1.64004864
179Rectal fistula (HP:0100590)1.64004864
180Increased CSF protein (HP:0002922)1.63873534
181Conjunctival telangiectasia (HP:0000524)1.63852680
182Absent forearm bone (HP:0003953)1.63412626
183Aplasia involving forearm bones (HP:0009822)1.63412626
184Abnormal biliary tract morphology (HP:0012440)1.62996965
185Generalized hypotonia (HP:0001290)1.61204398
186Ectropion (HP:0000656)1.61169309
187Renal agenesis (HP:0000104)1.60891337
188Thyroid carcinoma (HP:0002890)1.60211750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.24578387
2MKNK25.42334307
3TLK14.69038875
4BRSK23.47017597
5MKNK13.08169142
6CDK122.98796831
7STK38L2.70727664
8ERBB32.59015050
9BCR2.55881682
10FRK2.38570275
11STK242.38005015
12BLK2.36478880
13TRIM282.24416182
14GRK52.11031100
15MST1R2.07042012
16TNIK2.05961890
17GRK12.01911095
18MAP3K121.98110434
19FES1.97575506
20TSSK61.93309385
21GRK71.90076932
22ADRBK21.86004783
23WEE11.81504273
24PHKG11.73361039
25PHKG21.73361039
26SRPK11.55074596
27WNK31.51105969
28EIF2AK11.49836035
29MUSK1.45064276
30PRKD21.43845358
31STK31.42590531
32WNK11.41432009
33STK391.39061264
34MAP4K21.38018053
35PRPF4B1.37299700
36PKN11.32594144
37TGFBR21.30333812
38YES11.30091165
39BMPR1B1.21207849
40GRK61.20271173
41EIF2AK21.18446635
42HIPK21.15558380
43MET1.13973358
44NEK91.13951589
45CSK1.13369432
46PLK31.13314264
47IRAK31.09644338
48FER1.08862130
49PAK31.08372719
50INSRR1.08126771
51IRAK21.07020358
52IRAK11.05894225
53MST41.05137341
54EPHA31.04617097
55CLK11.03985589
56LATS11.01599748
57NLK1.01235285
58AKT30.97604033
59IRAK40.97143163
60PLK20.96738963
61PINK10.96628881
62ERBB40.94295646
63FGFR10.92282192
64MAPKAPK50.90005007
65CDK60.89637530
66PDK20.88477314
67FGR0.87119489
68ACVR1B0.86796221
69STK160.86165078
70PRKCE0.86111995
71MAPK150.85309838
72CSNK1G10.85044899
73NME20.84566916
74MAPK70.82440886
75MYLK0.82397687
76NUAK10.81166344
77DYRK1A0.79090412
78MARK20.78482495
79CSNK1A1L0.77208468
80TGFBR10.77162439
81CDK70.76252699
82STK100.73843649
83OXSR10.72771724
84LMTK20.72212476
85MAP3K40.71720497
86CSF1R0.71418861
87CDK190.67987008
88RPS6KA50.67926785
89PRKAA20.65923961
90BRD40.65497814
91PRKCI0.64639456
92TTK0.64623181
93PLK10.63782011
94FLT30.59597750
95MATK0.59002297
96MARK30.58841022
97TRPM70.57735858
98ADRBK10.57672951
99EPHA20.57040818
100TNK20.56225250
101PIK3CG0.55474969
102MOS0.54565874
103PNCK0.54376511
104UHMK10.54197554
105PIK3CA0.53146973
106CSNK1G30.52081765
107PAK40.51671037
108CAMK40.51550939
109BRSK10.50082951
110CDK30.49857634
111MAPK130.49467120
112TAF10.48501446
113ATM0.47519281
114FGFR20.46037202
115PRKG20.44968532
116MAPKAPK30.44678751
117PDGFRB0.44614606
118PBK0.43757791
119IGF1R0.43140546
120PAK10.42802420
121CAMK2B0.42141731
122NEK60.41752012
123TIE10.41244733
124PRKG10.41205603
125ZAK0.41064961
126EIF2AK30.40703441
127ABL10.40226500
128MAP3K50.39284298
129PAK20.39162001
130PLK40.37919181
131SGK20.37644647
132TYRO30.37568664
133MAP2K20.37216875
134MAPK100.37089087
135STK110.36427429
136NME10.35175024
137EGFR0.34677441
138VRK10.34572743
139CAMKK20.34423188
140CSNK1D0.34160122
141TAOK30.33328634
142CSNK1E0.32676995
143CDK90.32334744
144DYRK20.32281852
145LCK0.31244449
146BUB10.30302853
147IKBKB0.30089928
148PRKCQ0.29948223
149PIM20.29879469
150CSNK1G20.29362978
151CHEK20.28780267
152GSK3A0.28195930
153BMPR20.27972347
154DYRK30.27746727
155TXK0.27614250
156TEC0.27268742
157PRKD10.25703030
158HCK0.25317721

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.37112302
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.92491728
3Propanoate metabolism_Homo sapiens_hsa006402.62132807
4Ribosome_Homo sapiens_hsa030102.56446262
5Fanconi anemia pathway_Homo sapiens_hsa034602.33083185
6Phototransduction_Homo sapiens_hsa047442.30228590
7Steroid biosynthesis_Homo sapiens_hsa001002.25476768
8Fatty acid elongation_Homo sapiens_hsa000622.12631849
9Regulation of autophagy_Homo sapiens_hsa041402.08416876
10Ether lipid metabolism_Homo sapiens_hsa005652.02798437
11Arachidonic acid metabolism_Homo sapiens_hsa005902.00577645
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95433576
13Other glycan degradation_Homo sapiens_hsa005111.89058974
14Circadian rhythm_Homo sapiens_hsa047101.78682436
15Sulfur metabolism_Homo sapiens_hsa009201.70946071
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.70631145
17Sphingolipid metabolism_Homo sapiens_hsa006001.68592702
18Homologous recombination_Homo sapiens_hsa034401.66277083
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.65673399
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60598412
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54930093
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52270030
23Long-term depression_Homo sapiens_hsa047301.50772091
24Linoleic acid metabolism_Homo sapiens_hsa005911.49708973
25Nitrogen metabolism_Homo sapiens_hsa009101.46969176
26Axon guidance_Homo sapiens_hsa043601.40181033
27Vitamin B6 metabolism_Homo sapiens_hsa007501.39008004
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34445810
29Basal transcription factors_Homo sapiens_hsa030221.33166985
30Caffeine metabolism_Homo sapiens_hsa002321.30898877
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30593869
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29761582
33Nucleotide excision repair_Homo sapiens_hsa034201.28588318
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28275514
35Taste transduction_Homo sapiens_hsa047421.27726838
36beta-Alanine metabolism_Homo sapiens_hsa004101.26407350
37Basal cell carcinoma_Homo sapiens_hsa052171.25632537
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24868452
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24441145
40Nicotine addiction_Homo sapiens_hsa050331.23294787
41Wnt signaling pathway_Homo sapiens_hsa043101.21452623
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21373685
43Spliceosome_Homo sapiens_hsa030401.19181581
44Peroxisome_Homo sapiens_hsa041461.15628026
45Glutathione metabolism_Homo sapiens_hsa004801.14949364
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13645647
47Serotonergic synapse_Homo sapiens_hsa047261.12804901
48Mismatch repair_Homo sapiens_hsa034301.12752000
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12157969
50Selenocompound metabolism_Homo sapiens_hsa004501.12001574
51Protein export_Homo sapiens_hsa030601.10494602
52Histidine metabolism_Homo sapiens_hsa003401.10355984
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.09572893
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07806903
55TGF-beta signaling pathway_Homo sapiens_hsa043501.07117478
56Primary immunodeficiency_Homo sapiens_hsa053401.05358208
57N-Glycan biosynthesis_Homo sapiens_hsa005101.04736338
58Rheumatoid arthritis_Homo sapiens_hsa053231.04025011
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01232671
60Non-homologous end-joining_Homo sapiens_hsa034501.01007558
61Primary bile acid biosynthesis_Homo sapiens_hsa001201.00283522
62Autoimmune thyroid disease_Homo sapiens_hsa053200.97652197
63RNA polymerase_Homo sapiens_hsa030200.97177454
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96928367
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96237287
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95268877
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94624699
68Chemical carcinogenesis_Homo sapiens_hsa052040.94176259
69Glutamatergic synapse_Homo sapiens_hsa047240.94050432
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.91071154
71MicroRNAs in cancer_Homo sapiens_hsa052060.88135900
72Hematopoietic cell lineage_Homo sapiens_hsa046400.87983865
73Systemic lupus erythematosus_Homo sapiens_hsa053220.87949799
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.86542649
75Melanogenesis_Homo sapiens_hsa049160.86171524
76Hedgehog signaling pathway_Homo sapiens_hsa043400.84984591
77Tryptophan metabolism_Homo sapiens_hsa003800.84055000
78Choline metabolism in cancer_Homo sapiens_hsa052310.83861985
79RNA transport_Homo sapiens_hsa030130.83770894
80Prostate cancer_Homo sapiens_hsa052150.83453401
81Butanoate metabolism_Homo sapiens_hsa006500.83184996
82Oxidative phosphorylation_Homo sapiens_hsa001900.83035977
83Asthma_Homo sapiens_hsa053100.83022135
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82450616
85Fatty acid metabolism_Homo sapiens_hsa012120.79850338
86Fatty acid degradation_Homo sapiens_hsa000710.79372135
87Ras signaling pathway_Homo sapiens_hsa040140.79275400
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78142623
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77770212
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77186870
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76905345
92Malaria_Homo sapiens_hsa051440.76091669
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75213640
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.74709012
95T cell receptor signaling pathway_Homo sapiens_hsa046600.73924767
96Ovarian steroidogenesis_Homo sapiens_hsa049130.72751555
97Lysosome_Homo sapiens_hsa041420.70707825
98Pathways in cancer_Homo sapiens_hsa052000.70086230
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.68678117
100Calcium signaling pathway_Homo sapiens_hsa040200.68644853
101Melanoma_Homo sapiens_hsa052180.68556719
102Collecting duct acid secretion_Homo sapiens_hsa049660.64388400
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64228318
104ECM-receptor interaction_Homo sapiens_hsa045120.63606242
105Thyroid cancer_Homo sapiens_hsa052160.63467465
106Graft-versus-host disease_Homo sapiens_hsa053320.60390784
107Dorso-ventral axis formation_Homo sapiens_hsa043200.58838232
108ABC transporters_Homo sapiens_hsa020100.58364358
109Metabolic pathways_Homo sapiens_hsa011000.57827649
110Retinol metabolism_Homo sapiens_hsa008300.55827814
111MAPK signaling pathway_Homo sapiens_hsa040100.55525816
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.55518673
113GnRH signaling pathway_Homo sapiens_hsa049120.55499605
114African trypanosomiasis_Homo sapiens_hsa051430.55094218
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54402115
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.54303905
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52918533
118Adherens junction_Homo sapiens_hsa045200.52718891
119Morphine addiction_Homo sapiens_hsa050320.52379013
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52276605
121ErbB signaling pathway_Homo sapiens_hsa040120.52214500
122Vitamin digestion and absorption_Homo sapiens_hsa049770.51259549
123Salivary secretion_Homo sapiens_hsa049700.51091978
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.50534619
125Cell cycle_Homo sapiens_hsa041100.50442682
126Alcoholism_Homo sapiens_hsa050340.50070002
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50038517
128Rap1 signaling pathway_Homo sapiens_hsa040150.49401780
129Pyruvate metabolism_Homo sapiens_hsa006200.49337468
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.48816316
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48454341
132Allograft rejection_Homo sapiens_hsa053300.48086929
133Herpes simplex infection_Homo sapiens_hsa051680.47683387
134mRNA surveillance pathway_Homo sapiens_hsa030150.47357081
135Renal cell carcinoma_Homo sapiens_hsa052110.46809550
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.44971515
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44571410
138Inositol phosphate metabolism_Homo sapiens_hsa005620.44485442
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44442484
140Legionellosis_Homo sapiens_hsa051340.42721099
141RNA degradation_Homo sapiens_hsa030180.42016795
142cAMP signaling pathway_Homo sapiens_hsa040240.41810993
143Notch signaling pathway_Homo sapiens_hsa043300.40722804
144Tight junction_Homo sapiens_hsa045300.40575716
145Acute myeloid leukemia_Homo sapiens_hsa052210.40212443
146B cell receptor signaling pathway_Homo sapiens_hsa046620.39745566
147p53 signaling pathway_Homo sapiens_hsa041150.38794608
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38144077
149Renin secretion_Homo sapiens_hsa049240.37864062
150Vibrio cholerae infection_Homo sapiens_hsa051100.37600125
151Protein digestion and absorption_Homo sapiens_hsa049740.37312383
152Tyrosine metabolism_Homo sapiens_hsa003500.36647828
153Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36274378
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36192803
155Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35757071
156Mineral absorption_Homo sapiens_hsa049780.34027877
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.31828903
158Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30645204
159Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30033465
160Huntingtons disease_Homo sapiens_hsa050160.29613914
161Type I diabetes mellitus_Homo sapiens_hsa049400.28211933
162Purine metabolism_Homo sapiens_hsa002300.27129357
163Arginine and proline metabolism_Homo sapiens_hsa003300.26920407
164Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25735434
165Starch and sucrose metabolism_Homo sapiens_hsa005000.23578895
166Glycerolipid metabolism_Homo sapiens_hsa005610.22832051

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