TMEM87B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may interact with human papillomavirus type 18 E6 oncogene. The protein is also likely to be involved in endosome-to-trans-Golgi network retrograde transport. The gene is expressed in adult and fetal tissues, including brain and heart. This gene is a component of the 2q13 deletion syndrome. Mutations in this gene may be associated with congenital heart defects. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.23362680
2desmosome organization (GO:0002934)4.17771281
3hypotonic response (GO:0006971)4.07772276
4Golgi transport vesicle coating (GO:0048200)3.84632460
5COPI coating of Golgi vesicle (GO:0048205)3.84632460
6skin morphogenesis (GO:0043589)3.59897925
7protein localization to endosome (GO:0036010)3.50575487
8COPII vesicle coating (GO:0048208)3.46963468
9angiotensin maturation (GO:0002003)3.37353214
10regulation of extracellular matrix disassembly (GO:0010715)3.24206757
11phospholipid homeostasis (GO:0055091)3.23365696
12regulation of transforming growth factor beta1 production (GO:0032908)3.16275283
13peptide catabolic process (GO:0043171)3.00904097
14macroautophagy (GO:0016236)3.00030340
15bundle of His cell to Purkinje myocyte communication (GO:0086069)2.98444634
16positive regulation of cellular amide metabolic process (GO:0034250)2.84654669
17embryonic process involved in female pregnancy (GO:0060136)2.83790398
18negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.81712518
19endodermal cell differentiation (GO:0035987)2.76506641
20positive regulation by symbiont of host defense response (GO:0052509)2.75999924
21modulation by symbiont of host defense response (GO:0052031)2.75999924
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.75999924
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.75999924
24positive regulation by organism of defense response of other organism involved in symbiotic interact2.75999924
25modulation by symbiont of host immune response (GO:0052553)2.75999924
26response to laminar fluid shear stress (GO:0034616)2.72081085
27sequestering of extracellular ligand from receptor (GO:0035581)2.69779265
28surfactant homeostasis (GO:0043129)2.68857875
29iron ion import (GO:0097286)2.66075552
30positive regulation of p38MAPK cascade (GO:1900745)2.63801037
31branching involved in mammary gland duct morphogenesis (GO:0060444)2.59358003
32pinocytosis (GO:0006907)2.59337138
33intestinal epithelial cell development (GO:0060576)2.59004329
34regulation of interferon-beta biosynthetic process (GO:0045357)2.58468229
35cell-substrate junction assembly (GO:0007044)2.58428244
36negative regulation of protein localization to plasma membrane (GO:1903077)2.56451015
37membrane protein ectodomain proteolysis (GO:0006509)2.56231767
38cellular response to vitamin D (GO:0071305)2.55861748
39vesicle coating (GO:0006901)2.55770285
40regulation of transforming growth factor beta2 production (GO:0032909)2.55177278
41mesodermal cell differentiation (GO:0048333)2.55079672
42lipoprotein transport (GO:0042953)2.49619570
43cellular ketone body metabolic process (GO:0046950)2.49579460
44barbed-end actin filament capping (GO:0051016)2.49214967
45membrane raft organization (GO:0031579)2.47341182
46negative regulation of fatty acid transport (GO:2000192)2.44987168
47ketone body metabolic process (GO:1902224)2.42436773
48microglial cell activation (GO:0001774)2.42431849
49wound healing, spreading of epidermal cells (GO:0035313)2.42396529
50apoptotic cell clearance (GO:0043277)2.40735392
51intracellular lipid transport (GO:0032365)2.40528156
52I-kappaB phosphorylation (GO:0007252)2.40330894
53positive regulation of extracellular matrix organization (GO:1903055)2.38597127
54positive regulation of Cdc42 GTPase activity (GO:0043089)2.38115747
55multicellular organismal catabolic process (GO:0044243)2.38013067
56cell adhesion mediated by integrin (GO:0033627)2.37929442
57positive regulation of endothelial cell apoptotic process (GO:2000353)2.37233101
58response to lipoprotein particle (GO:0055094)2.36812109
59mammary gland epithelial cell proliferation (GO:0033598)2.35837704
60glycosphingolipid catabolic process (GO:0046479)2.35818858
61positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.35116636
62adhesion of symbiont to host cell (GO:0044650)2.33356873
63virion attachment to host cell (GO:0019062)2.33356873
64epithelial cell-cell adhesion (GO:0090136)2.33296273
65multicellular organismal macromolecule metabolic process (GO:0044259)2.32352649
66positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.31541132
67oligosaccharide catabolic process (GO:0009313)2.31331005
68negative regulation of lipid storage (GO:0010888)2.29803129
69ER overload response (GO:0006983)2.29315002
70multicellular organismal metabolic process (GO:0044236)2.29058863
71extracellular matrix disassembly (GO:0022617)2.28442510
72glycolipid catabolic process (GO:0019377)2.27370060
73macrophage activation involved in immune response (GO:0002281)2.26227844
74maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.25978079
75regulation of transforming growth factor beta production (GO:0071634)2.25828242
76regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.25640594
77detection of molecule of bacterial origin (GO:0032490)2.25295699
78regulation of metalloenzyme activity (GO:0048552)2.24666864
79negative regulation of keratinocyte proliferation (GO:0010839)2.24493736
80regulation of extracellular matrix organization (GO:1903053)2.24131633
81collagen metabolic process (GO:0032963)2.24070710
82regulation of integrin activation (GO:0033623)2.23061144
83keratan sulfate catabolic process (GO:0042340)2.22640116
84dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.21897316
85chondrocyte proliferation (GO:0035988)2.21695769
86pathway-restricted SMAD protein phosphorylation (GO:0060389)2.21343687
87collagen catabolic process (GO:0030574)2.19876975
88intestinal absorption (GO:0050892)2.19799378
89UDP-N-acetylglucosamine metabolic process (GO:0006047)2.19507462
90regulation of cholesterol homeostasis (GO:2000188)2.19270098
91protein targeting to Golgi (GO:0000042)2.19137135
92substrate-dependent cell migration (GO:0006929)2.18372813
93sphingomyelin metabolic process (GO:0006684)2.17640781
94stress fiber assembly (GO:0043149)2.17314196
95cellular response to vitamin (GO:0071295)2.16908928
96cholesterol efflux (GO:0033344)2.16189900
97collagen fibril organization (GO:0030199)2.15691189
98antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.15586101
99negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.14557754
100regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.14053605
101protein retention in ER lumen (GO:0006621)2.13753072
102regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.13740659
103establishment of protein localization to Golgi (GO:0072600)2.13530019
104positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.13370865
105antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.13370580
106adhesion of symbiont to host (GO:0044406)2.13136350
107reverse cholesterol transport (GO:0043691)2.11914449
108retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.11887900
109triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.11867057
110positive regulation of receptor recycling (GO:0001921)2.11334468
111positive regulation of cholesterol efflux (GO:0010875)2.11051407
112melanin biosynthetic process (GO:0042438)2.10933284
113negative regulation of complement activation (GO:0045916)2.10813962
114negative regulation of anoikis (GO:2000811)2.10312047
115regulation of macrophage derived foam cell differentiation (GO:0010743)2.10124071
116phospholipid efflux (GO:0033700)2.09915110
117fatty acid transmembrane transport (GO:1902001)2.08894827
118negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.07189199
119endocytic recycling (GO:0032456)2.06010754
120protein carboxylation (GO:0018214)2.05555087
121peptidyl-glutamic acid carboxylation (GO:0017187)2.05555087
122fibril organization (GO:0097435)2.05475168
123inner ear receptor cell development (GO:0060119)2.05374767
124retrograde transport, vesicle recycling within Golgi (GO:0000301)2.04824217
125positive regulation of blood vessel endothelial cell migration (GO:0043536)2.03491272
126positive regulation of glycolytic process (GO:0045821)2.03218231
127viral entry into host cell (GO:0046718)2.02979560
128very-low-density lipoprotein particle assembly (GO:0034379)2.02948537
129regulation of chemokine secretion (GO:0090196)2.02037577
130wound healing (GO:0042060)2.01852359
131regulation of keratinocyte differentiation (GO:0045616)2.01782658
132regulation of sequestering of triglyceride (GO:0010889)2.01457510
133lung lobe morphogenesis (GO:0060463)2.00294620
134secondary metabolite biosynthetic process (GO:0044550)1.99654789
135hyaluronan catabolic process (GO:0030214)1.99479614
136regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.99196410
137regulation of syncytium formation by plasma membrane fusion (GO:0060142)1.99004332
138relaxation of cardiac muscle (GO:0055119)1.98819944
139fibroblast migration (GO:0010761)1.98754589
140macrophage activation (GO:0042116)1.98348310
141lipoprotein metabolic process (GO:0042157)1.97974189
142tyrosine metabolic process (GO:0006570)1.96935146
143regulation of p38MAPK cascade (GO:1900744)1.96453057
144positive regulation of sterol transport (GO:0032373)1.96200633
145positive regulation of cholesterol transport (GO:0032376)1.96200633
146regulation of membrane protein ectodomain proteolysis (GO:0051043)1.94689571
147alanine transport (GO:0032328)1.94511618
148plasma lipoprotein particle clearance (GO:0034381)1.92830855
149cytoplasmic mRNA processing body assembly (GO:0033962)1.92718537
150mannose metabolic process (GO:0006013)1.92085518
151carnitine shuttle (GO:0006853)1.91578575
152regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.91246916
153positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)1.90934740
154low-density lipoprotein particle clearance (GO:0034383)1.89290542
155urea cycle (GO:0000050)1.88191724
156urea metabolic process (GO:0019627)1.88191724
157response to host immune response (GO:0052572)1.87342357
158response to immune response of other organism involved in symbiotic interaction (GO:0052564)1.87342357
159regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.86727495
160regulation of cholesterol storage (GO:0010885)1.86572437
161regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.86010909
162Golgi to endosome transport (GO:0006895)1.85205395
163melanin metabolic process (GO:0006582)1.85136938
164cholesterol transport (GO:0030301)1.84604407
165sterol transport (GO:0015918)1.84604407
166regulation of energy homeostasis (GO:2000505)1.84555704
167negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)1.83840913
168positive regulation of macrophage cytokine production (GO:0060907)1.83118225
169negative regulation of protein activation cascade (GO:2000258)1.82209497
170negative regulation of neurotransmitter secretion (GO:0046929)1.82158317
171neuron remodeling (GO:0016322)1.82154398
172bile acid and bile salt transport (GO:0015721)1.82068241
173endoplasmic reticulum organization (GO:0007029)1.81695526
174homocysteine metabolic process (GO:0050667)1.81214649
175positive regulation of interleukin-8 biosynthetic process (GO:0045416)1.80168067
176metanephric mesenchyme development (GO:0072075)1.79546328
177drug catabolic process (GO:0042737)1.78901392
178regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022351.78094718
179complement activation, alternative pathway (GO:0006957)1.77260220
180import into cell (GO:0098657)1.75761060
181insulin-like growth factor receptor signaling pathway (GO:0048009)1.75466309
182L-phenylalanine catabolic process (GO:0006559)1.73852458
183erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)1.73852458
184antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G1.73760284
185growth hormone receptor signaling pathway (GO:0060396)1.72944902
186phospholipid translocation (GO:0045332)1.72744932
187lipid translocation (GO:0034204)1.72744932
188response to defenses of other organism involved in symbiotic interaction (GO:0052173)1.72185496
189response to host defenses (GO:0052200)1.72185496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.91696503
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.41744032
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.68759450
4* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.53894577
5GBX2_23144817_ChIP-Seq_PC3_Human2.51907281
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17348136
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15018954
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05842134
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05352772
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.03956449
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03732519
12* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.02898436
13* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.02898436
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00519669
15CDX2_20551321_ChIP-Seq_CACO-2_Human1.97870359
16* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.94718584
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93967650
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91401761
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84975281
20* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.82685012
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82271904
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.82148516
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81769520
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.78670340
25* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73204001
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71869836
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70798487
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70732257
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70167741
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.68283919
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68044586
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67466708
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64166178
34GATA4_25053715_ChIP-Seq_YYC3_Human1.52232035
35* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.52110381
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51253106
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50734916
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50734916
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50374821
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.48818036
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48491177
42* RXR_22158963_ChIP-Seq_LIVER_Mouse1.46667681
43TP53_16413492_ChIP-PET_HCT116_Human1.45395005
44BRD4_25478319_ChIP-Seq_HGPS_Human1.45167156
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43485837
46EZH2_22144423_ChIP-Seq_EOC_Human1.42720208
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41305916
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41224699
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40532714
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40509440
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.39625081
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.38924251
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38468774
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.37676873
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.37333312
56GATA6_25053715_ChIP-Seq_YYC3_Human1.37109899
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36490712
58AHR_22903824_ChIP-Seq_MCF-7_Human1.36092875
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.36054066
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.35381800
61CJUN_26792858_Chip-Seq_BT549_Human1.33218621
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31549274
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30733503
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30280875
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29865071
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29407536
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28488252
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.25996698
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.25658881
70P300_19829295_ChIP-Seq_ESCs_Human1.25015355
71STAT3_23295773_ChIP-Seq_U87_Human1.24995648
72AR_25329375_ChIP-Seq_VCAP_Human1.24870103
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.24420881
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22851032
75BCAT_22108803_ChIP-Seq_LS180_Human1.22682851
76RXR_22108803_ChIP-Seq_LS180_Human1.21962076
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.21866834
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21654873
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20895441
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19581268
81FOXA2_19822575_ChIP-Seq_HepG2_Human1.19154121
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18416860
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17905436
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17490142
85* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17433241
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16571659
87* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16409547
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14649844
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14376814
90AR_21572438_ChIP-Seq_LNCaP_Human1.14138408
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13743219
92* IRF8_27001747_Chip-Seq_BMDM_Mouse1.11801048
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11647340
94DROSHA_22980978_ChIP-Seq_HELA_Human1.11604657
95TP53_18474530_ChIP-ChIP_U2OS_Human1.11519225
96CLOCK_20551151_ChIP-Seq_293T_Human1.11250143
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11030573
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10731960
99SOX2_20726797_ChIP-Seq_SW620_Human1.09928333
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08966414
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08927476
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08047737
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07333369
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.07258636
105RUNX_20019798_ChIP-Seq_JUKART_Human1.07257876
106* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07094715
107* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06146319
108* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05473907
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05263416
110RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04935949
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04935949
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.03846757
113* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03392537
114VDR_24787735_ChIP-Seq_THP-1_Human1.03079319
115RUNX2_22187159_ChIP-Seq_PCA_Human1.02755618
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02295179
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.01522722
118* GATA2_19941826_ChIP-Seq_K562_Human1.01520360
119GATA3_24758297_ChIP-Seq_MCF-7_Human1.01123613
120* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00790516
121WT1_19549856_ChIP-ChIP_CCG9911_Human1.00769160
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00566103
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00522279
124WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00298769
125* TP63_23658742_ChIP-Seq_EP156T_Human0.99636723
126TCF4_23295773_ChIP-Seq_U87_Human0.98860863
127PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98801533
128* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98615649
129ER_23166858_ChIP-Seq_MCF-7_Human0.98305331
130GATA1_22025678_ChIP-Seq_K562_Human0.97864765
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96318349
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95906192
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95113905
134EED_16625203_ChIP-ChIP_MESCs_Mouse0.95020456
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94978359
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94873770
137GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94488869
138SPI1_23127762_ChIP-Seq_K562_Human0.94103633
139ELK3_25401928_ChIP-Seq_HUVEC_Human0.94067963
140ZNF263_19887448_ChIP-Seq_K562_Human0.92912956
141BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92517229
142CDX2_22108803_ChIP-Seq_LS180_Human0.92072515
143FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91816713
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91045173
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90785010
146FOXA1_25552417_ChIP-Seq_VCAP_Human0.90561103
147KLF5_25053715_ChIP-Seq_YYC3_Human0.89739808
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89475643
149* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89356927
150STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89265007
151AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87122133
152PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86999428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.67775693
2MP0005058_abnormal_lysosome_morphology3.35905114
3MP0005360_urolithiasis3.05863461
4MP0005670_abnormal_white_adipose2.76630399
5MP0003566_abnormal_cell_adhesion2.63245411
6MP0002139_abnormal_hepatobiliary_system2.62367957
7MP0010352_gastrointestinal_tract_polyps2.62325514
8MP0008438_abnormal_cutaneous_collagen2.62280746
9MP0003183_abnormal_peptide_metabolism2.45018719
10MP0003172_abnormal_lysosome_physiology2.40659872
11MP0006054_spinal_hemorrhage2.32890783
12MP0009780_abnormal_chondrocyte_physiolo2.02524232
13MP0010386_abnormal_urinary_bladder2.02303891
14MP0004043_abnormal_pH_regulation2.01999693
15MP0003252_abnormal_bile_duct1.99988894
16MP0005257_abnormal_intraocular_pressure1.98186403
17MP0003300_gastrointestinal_ulcer1.97130187
18MP0005365_abnormal_bile_salt1.95395913
19MP0003690_abnormal_glial_cell1.92561222
20MP0005171_absent_coat_pigmentation1.88314629
21MP0003705_abnormal_hypodermis_morpholog1.83161153
22MP0005409_darkened_coat_color1.81846101
23MP0003045_fibrosis1.81368117
24MP0003191_abnormal_cellular_cholesterol1.80080367
25MP0005023_abnormal_wound_healing1.79626694
26MP0003279_aneurysm1.72459793
27MP0000372_irregular_coat_pigmentation1.62455443
28MP0003941_abnormal_skin_development1.62137822
29MP0009840_abnormal_foam_cell1.60805523
30MP0002796_impaired_skin_barrier1.60394930
31MP0000015_abnormal_ear_pigmentation1.58065998
32MP0010329_abnormal_lipoprotein_level1.56783885
33MP0004130_abnormal_muscle_cell1.53982823
34MP0010155_abnormal_intestine_physiology1.50523671
35MP0000013_abnormal_adipose_tissue1.50405572
36MP0004947_skin_inflammation1.48964204
37MP0005666_abnormal_adipose_tissue1.45365132
38MP0005408_hypopigmentation1.43442890
39MP0005085_abnormal_gallbladder_physiolo1.42643019
40MP0000538_abnormal_urinary_bladder1.41151433
41MP0009384_cardiac_valve_regurgitation1.36792138
42MP0000858_altered_metastatic_potential1.33519664
43MP0004272_abnormal_basement_membrane1.33037515
44MP0003436_decreased_susceptibility_to1.31960197
45MP0004782_abnormal_surfactant_physiolog1.31936244
46MP0000003_abnormal_adipose_tissue1.30023461
47MP0002877_abnormal_melanocyte_morpholog1.29242140
48MP0005375_adipose_tissue_phenotype1.27962369
49MP0008260_abnormal_autophagy1.27758038
50MP0003195_calcinosis1.27041130
51MP0000604_amyloidosis1.26429039
52MP0005164_abnormal_response_to1.26256188
53MP0001216_abnormal_epidermal_layer1.26058079
54MP0008875_abnormal_xenobiotic_pharmacok1.25258825
55MP0002118_abnormal_lipid_homeostasis1.23456574
56MP0005464_abnormal_platelet_physiology1.21711170
57MP0001958_emphysema1.21657514
58MP0003868_abnormal_feces_composition1.20503846
59MP0001873_stomach_inflammation1.20140089
60MP0000465_gastrointestinal_hemorrhage1.19737036
61MP0001666_abnormal_nutrient_absorption1.17860035
62MP0004885_abnormal_endolymph1.17297279
63MP0001849_ear_inflammation1.17155674
64MP0008004_abnormal_stomach_pH1.16849747
65MP0000371_diluted_coat_color1.16161284
66MP0005275_abnormal_skin_tensile1.15621533
67MP0000427_abnormal_hair_cycle1.15083335
68MP0004270_analgesia1.13501000
69MP0003828_pulmonary_edema1.13091251
70MP0004264_abnormal_extraembryonic_tissu1.13012760
71MP0001299_abnormal_eye_distance/1.11362984
72MP0003950_abnormal_plasma_membrane1.11090057
73MP0002909_abnormal_adrenal_gland1.09365599
74MP0002009_preneoplasia1.09207762
75MP0002998_abnormal_bone_remodeling1.09086616
76MP0000767_abnormal_smooth_muscle1.08976531
77MP0001533_abnormal_skeleton_physiology1.07398570
78MP0010368_abnormal_lymphatic_system1.07258934
79MP0005334_abnormal_fat_pad1.05171615
80MP0003091_abnormal_cell_migration1.05055528
81MP0001835_abnormal_antigen_presentation1.04155532
82MP0002896_abnormal_bone_mineralization1.02445689
83MP0005332_abnormal_amino_acid1.02434417
84MP0010678_abnormal_skin_adnexa1.02011386
85MP0005310_abnormal_salivary_gland1.00080834
86MP0002098_abnormal_vibrissa_morphology0.99572277
87MP0002168_other_aberrant_phenotype0.99514559
88MP0005166_decreased_susceptibility_to0.99140678
89MP0003448_altered_tumor_morphology0.98228922
90MP0005503_abnormal_tendon_morphology0.98115960
91MP0001324_abnormal_eye_pigmentation0.97556462
92MP0004185_abnormal_adipocyte_glucose0.97384298
93MP0000627_abnormal_mammary_gland0.96837925
94MP0002295_abnormal_pulmonary_circulatio0.96490140
95MP0000609_abnormal_liver_physiology0.95869400
96MP0002876_abnormal_thyroid_physiology0.95850928
97MP0002971_abnormal_brown_adipose0.95485345
98MP0005501_abnormal_skin_physiology0.94955762
99MP0005645_abnormal_hypothalamus_physiol0.94583749
100MP0004883_abnormal_blood_vessel0.94015812
101MP0000383_abnormal_hair_follicle0.93648499
102MP0002090_abnormal_vision0.92641115
103MP0000462_abnormal_digestive_system0.91898055
104MP0003866_abnormal_defecation0.90344543
105MP0001661_extended_life_span0.89071107
106MP0004742_abnormal_vestibular_system0.88871664
107MP0002166_altered_tumor_susceptibility0.88521396
108MP0010234_abnormal_vibrissa_follicle0.88517035
109MP0001881_abnormal_mammary_gland0.87951518
110MP0006082_CNS_inflammation0.87891693
111MP0000477_abnormal_intestine_morphology0.87759139
112MP0001243_abnormal_dermal_layer0.87609962
113MP0003724_increased_susceptibility_to0.86969503
114MP0005387_immune_system_phenotype0.84701506
115MP0001790_abnormal_immune_system0.84701506
116MP0000685_abnormal_immune_system0.84613887
117MP0002138_abnormal_hepatobiliary_system0.83504539
118MP0000467_abnormal_esophagus_morphology0.82117263
119MP0001845_abnormal_inflammatory_respons0.81951261
120MP0002136_abnormal_kidney_physiology0.81735790
121MP0003795_abnormal_bone_structure0.81718292
122MP0009785_altered_susceptibility_to0.80840708
123MP0001915_intracranial_hemorrhage0.80174493
124MP0002078_abnormal_glucose_homeostasis0.80171013
125MP0005165_increased_susceptibility_to0.79765516
126MP0001542_abnormal_bone_strength0.78824574
127MP0002060_abnormal_skin_morphology0.78434043
128MP0005451_abnormal_body_composition0.78194112
129MP0000249_abnormal_blood_vessel0.78082339
130MP0001501_abnormal_sleep_pattern0.78016249
131MP0009643_abnormal_urine_homeostasis0.77065130
132MP0001502_abnormal_circadian_rhythm0.76917272
133MP0000377_abnormal_hair_follicle0.76430697
134MP0002928_abnormal_bile_duct0.75724149
135MP0003634_abnormal_glial_cell0.75381095
136MP0005377_hearing/vestibular/ear_phenot0.75363431
137MP0003878_abnormal_ear_physiology0.75363431
138MP0005197_abnormal_uvea_morphology0.75338655
139MP0001851_eye_inflammation0.75187552
140MP0001756_abnormal_urination0.74637183
141MP0000230_abnormal_systemic_arterial0.74044469
142MP0001440_abnormal_grooming_behavior0.74019713
143MP0002254_reproductive_system_inflammat0.73776938
144MP0005025_abnormal_response_to0.73065885
145MP0005535_abnormal_body_temperature0.72544832
146MP0001765_abnormal_ion_homeostasis0.72090047
147MP0002006_tumorigenesis0.71764181
148MP0005379_endocrine/exocrine_gland_phen0.70141785
149MP0001177_atelectasis0.69087958
150MP0004019_abnormal_vitamin_homeostasis0.68850150
151MP0002419_abnormal_innate_immunity0.68154567
152MP0003453_abnormal_keratinocyte_physiol0.67272053
153MP0009764_decreased_sensitivity_to0.67215764
154MP0002108_abnormal_muscle_morphology0.66651018

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)3.75048035
2Atrophic scars (HP:0001075)3.62864263
3Protrusio acetabuli (HP:0003179)3.57226551
4Flat acetabular roof (HP:0003180)3.54840938
5Conjugated hyperbilirubinemia (HP:0002908)3.50547084
6Right ventricular cardiomyopathy (HP:0011663)3.09197899
7Cervical subluxation (HP:0003308)3.08406886
8Submucous cleft hard palate (HP:0000176)3.06456975
9Follicular hyperkeratosis (HP:0007502)2.95543803
10Hematochezia (HP:0002573)2.93335524
11Dysostosis multiplex (HP:0000943)2.90224200
12Myocardial infarction (HP:0001658)2.73435884
13Fragile skin (HP:0001030)2.72695305
14Abnormality of polysaccharide metabolism (HP:0011012)2.68853117
15Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68853117
16Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68853117
17Blue irides (HP:0000635)2.64219735
18Systemic lupus erythematosus (HP:0002725)2.62688731
19Malnutrition (HP:0004395)2.60730729
20Urinary glycosaminoglycan excretion (HP:0003541)2.54796953
21Mucopolysacchariduria (HP:0008155)2.54796953
22Complement deficiency (HP:0004431)2.53444470
23Vacuolated lymphocytes (HP:0001922)2.52251051
24Xanthomatosis (HP:0000991)2.50469306
25Hyperactive renin-angiotensin system (HP:0000841)2.49531585
26Eczematoid dermatitis (HP:0000976)2.47376932
27Mitral stenosis (HP:0001718)2.42059882
28Aplasia/Hypoplasia of the macula (HP:0008059)2.39032922
29Hyperlipoproteinemia (HP:0010980)2.37047872
30Arterial tortuosity (HP:0005116)2.35706446
31Glomerulonephritis (HP:0000099)2.34589380
32Peripheral demyelination (HP:0011096)2.33426162
33Chronic diarrhea (HP:0002028)2.30976059
34Dilatation of the ascending aorta (HP:0005111)2.30834675
35Cardiovascular calcification (HP:0011915)2.30492406
36Generalized hypopigmentation of hair (HP:0011358)2.30120111
37Increased cerebral lipofuscin (HP:0011813)2.29641954
38Ankyloglossia (HP:0010296)2.28870580
39Neonatal short-limb short stature (HP:0008921)2.28236486
40Milia (HP:0001056)2.28154339
41Retinal atrophy (HP:0001105)2.27862498
42Segmental peripheral demyelination/remyelination (HP:0003481)2.26273791
43Hyperglycemia (HP:0003074)2.25812609
44Aplasia/Hypoplasia affecting the retina (HP:0008061)2.25063475
45Thick nail (HP:0001805)2.22073396
46Aneurysm (HP:0002617)2.21544916
47Neurofibrillary tangles (HP:0002185)2.19918834
48Thin bony cortex (HP:0002753)2.19798033
49Decreased circulating renin level (HP:0003351)2.19356028
50Prostate neoplasm (HP:0100787)2.18711239
51Peritonitis (HP:0002586)2.18381258
52Onycholysis (HP:0001806)2.16677256
53Hydroxyprolinuria (HP:0003080)2.14206822
54Abnormality of proline metabolism (HP:0010907)2.14206822
55Onion bulb formation (HP:0003383)2.13360893
56Abnormality of carpal bone ossification (HP:0006257)2.11503684
57Wormian bones (HP:0002645)2.10785407
58Plantar hyperkeratosis (HP:0007556)2.10715307
59Hypoalphalipoproteinemia (HP:0003233)2.09767062
60Global brain atrophy (HP:0002283)2.09407750
61Vertebral compression fractures (HP:0002953)2.09045378
62Abnormality of chloride homeostasis (HP:0011422)2.08512109
63Deep venous thrombosis (HP:0002625)2.08313072
64Progressive visual loss (HP:0000529)2.07556809
65Axonal loss (HP:0003447)2.07335531
66Soft skin (HP:0000977)2.06569182
67Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06411520
68Blue sclerae (HP:0000592)2.05959799
69Vascular tortuosity (HP:0004948)2.04714406
70Aortic aneurysm (HP:0004942)2.02713489
71Vascular calcification (HP:0004934)2.01732693
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.00954023
73Hyperkalemia (HP:0002153)1.99453726
74Abnormality of oral frenula (HP:0000190)1.98982300
75Abnormality of the acetabulum (HP:0003170)1.97606275
76Fat malabsorption (HP:0002630)1.97190187
77Severe short stature (HP:0003510)1.96939280
78Macroorchidism (HP:0000053)1.96282636
79Curly hair (HP:0002212)1.95477390
80Premature rupture of membranes (HP:0001788)1.95281689
81Abnormality of the ischium (HP:0003174)1.94675049
82Increased CSF protein (HP:0002922)1.94025819
83Skin nodule (HP:0200036)1.93170867
84Abnormality of glycolipid metabolism (HP:0010969)1.92775153
85Abnormality of liposaccharide metabolism (HP:0010968)1.92775153
86Abnormality of glycosphingolipid metabolism (HP:0004343)1.92775153
87Supranuclear gaze palsy (HP:0000605)1.92571146
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92544267
89Ovoid vertebral bodies (HP:0003300)1.92297761
90Abdominal distention (HP:0003270)1.92198821
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90930453
92Cubitus valgus (HP:0002967)1.89589053
93Loss of speech (HP:0002371)1.88800030
94Fair hair (HP:0002286)1.88176623
95Absent frontal sinuses (HP:0002688)1.86920807
96Progressive sensorineural hearing impairment (HP:0000408)1.85853282
97Bladder diverticulum (HP:0000015)1.84759643
98Congenital sensorineural hearing impairment (HP:0008527)1.84604833
99Ulnar claw (HP:0001178)1.84134021
100Cerebral inclusion bodies (HP:0100314)1.83694008
101Nephritis (HP:0000123)1.83163206
102Joint hemorrhage (HP:0005261)1.82425068
103Abnormal ossification of hand bones (HP:0005921)1.81472728
104Mitral valve prolapse (HP:0001634)1.81395843
105Abnormality of the common coagulation pathway (HP:0010990)1.81176223
106Thoracolumbar scoliosis (HP:0002944)1.81080641
107Long toe (HP:0010511)1.80145725
108Pheochromocytoma (HP:0002666)1.79978443
109J-shaped sella turcica (HP:0002680)1.77917227
110Abnormality of macrophages (HP:0004311)1.77709199
111Esophageal varix (HP:0002040)1.77585756
112Spondylolisthesis (HP:0003302)1.77578823
113Increased connective tissue (HP:0009025)1.77538002
114Natal tooth (HP:0000695)1.76975791
115Recurrent bacterial skin infections (HP:0005406)1.76284951
116Abnormal foot bone ossification (HP:0010675)1.76253329
117Coarse hair (HP:0002208)1.76080591
118Tetraparesis (HP:0002273)1.75579662
119Protuberant abdomen (HP:0001538)1.74916419
120Epidermoid cyst (HP:0200040)1.74724564
121Cupped ribs (HP:0000887)1.74719309
122Febrile seizures (HP:0002373)1.73654343
123Abnormality of dentin (HP:0010299)1.73164661
124Femoral bowing (HP:0002980)1.73059127
125Ankle contracture (HP:0006466)1.72965503
126Aortic dissection (HP:0002647)1.72415383
127Short nail (HP:0001799)1.71987047
128Abnormality of complement system (HP:0005339)1.71754166
129Periodontitis (HP:0000704)1.71475034
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.71281749
131Osteolytic defects of the hand bones (HP:0009699)1.71281749
132Abnormality of vision evoked potentials (HP:0000649)1.71158531
133Thickened calvaria (HP:0002684)1.70892773
134Abnormality of primary teeth (HP:0006481)1.70519770
135Abnormal hand bone ossification (HP:0010660)1.70335380
136Termporal pattern (HP:0011008)1.69972572
137Insidious onset (HP:0003587)1.69972572
138Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69309224
139Tibial bowing (HP:0002982)1.69222091
140Abnormality of the distal phalanges of the toes (HP:0010182)1.69069331
141Prolonged partial thromboplastin time (HP:0003645)1.68688779
142Premature loss of primary teeth (HP:0006323)1.68111045
143Cerebral aneurysm (HP:0004944)1.68008315
144Hypophosphatemia (HP:0002148)1.66908652
145Turricephaly (HP:0000262)1.66286574
146Bone pain (HP:0002653)1.65326007
147Gingivitis (HP:0000230)1.65194735
148Aplasia involving bones of the upper limbs (HP:0009823)1.64941727
149Aplasia of the phalanges of the hand (HP:0009802)1.64941727
150Aplasia involving bones of the extremities (HP:0009825)1.64941727
151Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.64917495
152Hypoplasia of dental enamel (HP:0006297)1.64695809
153Coxa vara (HP:0002812)1.64440504
154Pathologic fracture (HP:0002756)1.64194503
155Disinhibition (HP:0000734)1.63776987
156Flared iliac wings (HP:0002869)1.63509179
157Broad face (HP:0000283)1.62912428
158Palmoplantar hyperkeratosis (HP:0000972)1.62817261
159Spontaneous hematomas (HP:0007420)1.61894941
160Joint laxity (HP:0001388)1.61850646
161Spinal cord lesions (HP:0100561)1.61453439
162Syringomyelia (HP:0003396)1.61453439

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.43995656
2MKNK23.37221041
3ERN12.92898788
4EPHA22.86779048
5CAMK1D2.82234716
6LATS12.71709767
7FRK2.57661946
8CAMK1G2.51793706
9TAOK32.35393298
10SIK32.31559936
11AKT32.31021787
12RIPK42.17582672
13MAP3K132.15109643
14MAP3K141.92654947
15MYLK1.92430631
16INSRR1.90923851
17RIPK11.89731034
18STK241.85159814
19IRAK31.72860185
20SCYL21.70324544
21SGK21.67338910
22MAP3K121.59491166
23MAPK151.51066530
24PAK41.45463169
25STK391.44384928
26MST1R1.43050127
27SGK4941.42729668
28SGK2231.42729668
29BLK1.41692625
30ZAP701.35155887
31ACVR1B1.34518296
32SGK31.32910942
33PKN21.32495151
34JAK11.32433208
35MAP3K21.28907092
36MAP3K31.28593213
37FER1.27271395
38TRPM71.22469293
39WNK11.19010109
40SIK11.18747870
41BRD41.15876687
42JAK31.13976203
43NEK91.11987593
44BMPR1B1.09295814
45PRKG21.08960847
46NUAK11.08481595
47YES11.08283083
48MST41.07536782
49CDC42BPA1.06597866
50PLK21.06286974
51BCR1.05146182
52TYK21.04446585
53CSF1R1.04096160
54NTRK11.03647111
55MKNK11.02657591
56TGFBR21.02107355
57KSR11.01920143
58CAMKK21.01107084
59MAP3K61.00859726
60MARK30.97963119
61PTK60.97944956
62TESK10.96494756
63STK380.95425656
64BMPR20.94113221
65LMTK20.91780279
66DDR20.90884122
67MAP2K40.90647240
68PDGFRA0.90245948
69IRAK10.87876844
70SGK10.86481561
71PRKAA20.85661325
72CDK120.85577228
73MAPKAPK30.84843785
74DAPK20.82585196
75EPHA30.82162581
76TTN0.80788740
77TBK10.78285727
78EEF2K0.77190660
79EIF2AK30.77187188
80ERBB40.74916074
81PRPF4B0.74844982
82MAP3K40.73860510
83PIK3CA0.73189909
84STK30.73094874
85PRKCE0.72882421
86CDK90.72379971
87EPHB10.71409636
88PDGFRB0.71144373
89TRIM280.70574319
90GRK70.68727334
91MAP3K10.68273141
92FGFR20.67729387
93PIK3CG0.67205519
94RPS6KA20.67096282
95GRK60.66879946
96WNK30.66466490
97NEK60.65157167
98NTRK30.64706294
99IKBKE0.64697393
100FGR0.64468427
101MELK0.64277889
102MAP2K30.63532910
103PTK2B0.61123990
104MAP3K90.60913368
105RET0.60672696
106MET0.60167542
107PRKAA10.60067395
108LATS20.59049715
109PDPK10.58573546
110FGFR30.57932994
111MAP2K70.56845068
112MAP3K50.56105013
113PRKCH0.55462163
114MAP3K100.54349608
115KSR20.54075679
116STK38L0.52790656
117PAK20.52785848
118PTK20.52641254
119MAP3K70.50995732
120EPHB20.50345917
121JAK20.49554478
122SIK20.49528228
123MAP2K10.49252390
124WNK40.49067540
125CHUK0.47879522
126TEC0.47775918
127PKN10.47383871
128CDK60.46230928
129MATK0.45614520
130FGFR40.45354268
131MAPKAPK20.45298348
132NLK0.44995866
133STK100.44019114
134MAPK70.43133876
135GSK3A0.42993661
136PDK10.42642604
137EPHA40.42194768
138HIPK20.41248571
139KIT0.40954523
140MAPK120.40927881
141IGF1R0.40869129
142CSK0.40057825
143TRIB30.39743835
144ERBB30.39413908

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002321.84209074
2Renin-angiotensin system_Homo sapiens_hsa046141.82985461
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75811312
4Maturity onset diabetes of the young_Homo sapiens_hsa049501.61634265
5Butanoate metabolism_Homo sapiens_hsa006501.55698493
6Staphylococcus aureus infection_Homo sapiens_hsa051501.53422841
7Sulfur metabolism_Homo sapiens_hsa009201.44352763
8Leukocyte transendothelial migration_Homo sapiens_hsa046701.42328519
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40099175
10Lysosome_Homo sapiens_hsa041421.39734356
11Complement and coagulation cascades_Homo sapiens_hsa046101.39615361
12Mineral absorption_Homo sapiens_hsa049781.32378736
13Type II diabetes mellitus_Homo sapiens_hsa049301.30782850
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30304100
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29606103
16Galactose metabolism_Homo sapiens_hsa000521.27296619
17Lysine degradation_Homo sapiens_hsa003101.26398971
18Proteoglycans in cancer_Homo sapiens_hsa052051.23638266
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.22888487
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21421690
21PPAR signaling pathway_Homo sapiens_hsa033201.17217733
22Small cell lung cancer_Homo sapiens_hsa052221.15036222
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10458393
24Nitrogen metabolism_Homo sapiens_hsa009101.10216018
25Chronic myeloid leukemia_Homo sapiens_hsa052201.09851166
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09459642
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.07473522
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05166520
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04183338
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03997857
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03542824
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03158399
33TNF signaling pathway_Homo sapiens_hsa046681.02750745
34ABC transporters_Homo sapiens_hsa020101.02485680
35Bile secretion_Homo sapiens_hsa049761.01154151
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.99932847
37Dorso-ventral axis formation_Homo sapiens_hsa043200.99913601
38Starch and sucrose metabolism_Homo sapiens_hsa005000.97661100
39Collecting duct acid secretion_Homo sapiens_hsa049660.96827040
40Bladder cancer_Homo sapiens_hsa052190.95977449
41Fructose and mannose metabolism_Homo sapiens_hsa000510.95244608
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91908574
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91270492
44Other glycan degradation_Homo sapiens_hsa005110.91181028
45Fatty acid degradation_Homo sapiens_hsa000710.89658316
46Platelet activation_Homo sapiens_hsa046110.88639976
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87879933
48Insulin resistance_Homo sapiens_hsa049310.87861656
49Renal cell carcinoma_Homo sapiens_hsa052110.87826868
50Peroxisome_Homo sapiens_hsa041460.87733728
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87615377
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87411500
53Vitamin digestion and absorption_Homo sapiens_hsa049770.87342216
54Circadian rhythm_Homo sapiens_hsa047100.85796671
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.85265082
56Glycerolipid metabolism_Homo sapiens_hsa005610.85215953
57Phagosome_Homo sapiens_hsa041450.85206081
58Acute myeloid leukemia_Homo sapiens_hsa052210.84978052
59Thyroid cancer_Homo sapiens_hsa052160.84751708
60B cell receptor signaling pathway_Homo sapiens_hsa046620.84443663
61Arginine biosynthesis_Homo sapiens_hsa002200.83956437
62Rheumatoid arthritis_Homo sapiens_hsa053230.83326573
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83176733
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82449720
65Influenza A_Homo sapiens_hsa051640.81702082
66Shigellosis_Homo sapiens_hsa051310.80760099
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80298975
68Histidine metabolism_Homo sapiens_hsa003400.79879926
69Hematopoietic cell lineage_Homo sapiens_hsa046400.79374117
70Non-small cell lung cancer_Homo sapiens_hsa052230.78708530
71Fatty acid metabolism_Homo sapiens_hsa012120.78697922
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78127994
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77760140
74N-Glycan biosynthesis_Homo sapiens_hsa005100.77454449
75Tryptophan metabolism_Homo sapiens_hsa003800.76486426
76ECM-receptor interaction_Homo sapiens_hsa045120.76053308
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75999361
78Endometrial cancer_Homo sapiens_hsa052130.75199412
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75036769
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.75028136
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75005345
82Tuberculosis_Homo sapiens_hsa051520.74952332
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74544464
84Fat digestion and absorption_Homo sapiens_hsa049750.70737943
85Insulin secretion_Homo sapiens_hsa049110.69446881
86Ovarian steroidogenesis_Homo sapiens_hsa049130.67121096
87Osteoclast differentiation_Homo sapiens_hsa043800.66853147
88Hepatitis B_Homo sapiens_hsa051610.66661231
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.66461557
90Synaptic vesicle cycle_Homo sapiens_hsa047210.66010369
91Prion diseases_Homo sapiens_hsa050200.65830794
92mTOR signaling pathway_Homo sapiens_hsa041500.65455276
93Allograft rejection_Homo sapiens_hsa053300.65334052
94Taste transduction_Homo sapiens_hsa047420.64802488
95Endocytosis_Homo sapiens_hsa041440.64670015
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.64505209
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.64362411
98Inositol phosphate metabolism_Homo sapiens_hsa005620.63353874
99beta-Alanine metabolism_Homo sapiens_hsa004100.63021119
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62603394
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62487402
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61992360
103Autoimmune thyroid disease_Homo sapiens_hsa053200.61675345
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.61472048
105VEGF signaling pathway_Homo sapiens_hsa043700.60915061
106Thyroid hormone synthesis_Homo sapiens_hsa049180.60624986
107Asthma_Homo sapiens_hsa053100.60513769
108Insulin signaling pathway_Homo sapiens_hsa049100.59990266
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.59980033
110Renin secretion_Homo sapiens_hsa049240.59956831
111Salmonella infection_Homo sapiens_hsa051320.58570990
112Antigen processing and presentation_Homo sapiens_hsa046120.58516122
113Measles_Homo sapiens_hsa051620.58177932
114Sphingolipid metabolism_Homo sapiens_hsa006000.57524430
115Protein digestion and absorption_Homo sapiens_hsa049740.57177432
116Amoebiasis_Homo sapiens_hsa051460.57066080
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57046706
118Vibrio cholerae infection_Homo sapiens_hsa051100.57016181
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56716680
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56543443
121Viral myocarditis_Homo sapiens_hsa054160.56206190
122Chemokine signaling pathway_Homo sapiens_hsa040620.56160742
123Graft-versus-host disease_Homo sapiens_hsa053320.56046489
124GnRH signaling pathway_Homo sapiens_hsa049120.55998341
125Nicotine addiction_Homo sapiens_hsa050330.54892560
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.54844585
127Steroid biosynthesis_Homo sapiens_hsa001000.54797912
128Morphine addiction_Homo sapiens_hsa050320.54568040
129GABAergic synapse_Homo sapiens_hsa047270.54333279
130ErbB signaling pathway_Homo sapiens_hsa040120.53130773
131Salivary secretion_Homo sapiens_hsa049700.52756881
132HIF-1 signaling pathway_Homo sapiens_hsa040660.52508168
133Pancreatic secretion_Homo sapiens_hsa049720.51736123
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51679527
135Pertussis_Homo sapiens_hsa051330.51522510
136Hepatitis C_Homo sapiens_hsa051600.49777161
137Malaria_Homo sapiens_hsa051440.49556481
138Adherens junction_Homo sapiens_hsa045200.49527084
139FoxO signaling pathway_Homo sapiens_hsa040680.48588246
140Regulation of autophagy_Homo sapiens_hsa041400.48513182
141Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48190252
142Prolactin signaling pathway_Homo sapiens_hsa049170.48036740
143Choline metabolism in cancer_Homo sapiens_hsa052310.47495268
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.46269806
145Toxoplasmosis_Homo sapiens_hsa051450.46056837
146Prostate cancer_Homo sapiens_hsa052150.45085444
147Melanoma_Homo sapiens_hsa052180.44780325
148Glucagon signaling pathway_Homo sapiens_hsa049220.43740057
149Focal adhesion_Homo sapiens_hsa045100.43149942
150Pancreatic cancer_Homo sapiens_hsa052120.42990390
151Circadian entrainment_Homo sapiens_hsa047130.42265910
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42210385
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41484261
154Leishmaniasis_Homo sapiens_hsa051400.41297320

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