ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fatty acid elongation (GO:0030497)	7.96365896
2	ensheathment of neurons (GO:0007272)	7.01375831
3	axon ensheathment (GO:0008366)	7.01375831
4	myelination (GO:0042552)	6.98318029
5	long-chain fatty acid biosynthetic process (GO:0042759)	6.23844041
6	myelin maintenance (GO:0043217)	5.53664134
7	negative regulation of neurotransmitter secretion (GO:0046929)	5.26053734
8	negative regulation of neurotransmitter transport (GO:0051589)	5.06663384
9	cholesterol biosynthetic process (GO:0006695)	4.74052154
10	L-amino acid import (GO:0043092)	4.67872610
11	establishment of mitochondrion localization (GO:0051654)	4.58304354
12	negative regulation of protein localization to cell surface (GO:2000009)	4.56353741
13	regulation of collateral sprouting (GO:0048670)	4.53789676
14	oligodendrocyte differentiation (GO:0048709)	4.46049648
15	response to methylmercury (GO:0051597)	4.41464210
16	glycerophospholipid catabolic process (GO:0046475)	4.34959729
17	creatine metabolic process (GO:0006600)	4.31936225
18	positive regulation of oligodendrocyte differentiation (GO:0048714)	4.30550888
19	sterol biosynthetic process (GO:0016126)	4.24559791
20	photoreceptor cell differentiation (GO:0046530)	4.16965844
21	eye photoreceptor cell differentiation (GO:0001754)	4.16965844
22	presynaptic membrane organization (GO:0097090)	4.11912369
23	amyloid precursor protein metabolic process (GO:0042982)	4.03959697
24	apical protein localization (GO:0045176)	4.03583156
25	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	4.00599922
26	astrocyte development (GO:0014002)	3.99857881
27	asymmetric protein localization (GO:0008105)	3.98247805
28	import into cell (GO:0098657)	3.87233967
29	isoprenoid biosynthetic process (GO:0008299)	3.73838189
30	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	3.72682447
31	substantia nigra development (GO:0021762)	3.71019851
32	presynaptic membrane assembly (GO:0097105)	3.67501464
33	response to redox state (GO:0051775)	3.65226497
34	membrane tubulation (GO:0097320)	3.53675001
35	peptidyl-tyrosine autophosphorylation (GO:0038083)	3.51232013
36	regulation of lipoprotein metabolic process (GO:0050746)	3.50386767
37	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	3.50042227
38	response to lipoprotein particle (GO:0055094)	3.46895463
39	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.45598256
40	amino acid import (GO:0043090)	3.43117760
41	protein palmitoylation (GO:0018345)	3.40586458
42	GPI anchor biosynthetic process (GO:0006506)	3.40235476
43	adult walking behavior (GO:0007628)	3.37426675
44	magnesium ion transport (GO:0015693)	3.35965331
45	GPI anchor metabolic process (GO:0006505)	3.33413663
46	peripheral nervous system axon ensheathment (GO:0032292)	3.30081127
47	myelination in peripheral nervous system (GO:0022011)	3.30081127
48	fatty-acyl-CoA metabolic process (GO:0035337)	3.27687037
49	cerebral cortex radially oriented cell migration (GO:0021799)	3.23933444
50	neurotransmitter uptake (GO:0001504)	3.22235304
51	neuron remodeling (GO:0016322)	3.20276223
52	limb bud formation (GO:0060174)	3.19099059
53	axon development (GO:0061564)	3.12887201
54	preassembly of GPI anchor in ER membrane (GO:0016254)	3.08047965
55	very long-chain fatty acid metabolic process (GO:0000038)	3.06617133
56	negative regulation of axonogenesis (GO:0050771)	3.02597494
57	glycosylceramide metabolic process (GO:0006677)	3.01419637
58	adhesion of symbiont to host cell (GO:0044650)	2.95987729
59	virion attachment to host cell (GO:0019062)	2.95987729
60	neuron cell-cell adhesion (GO:0007158)	2.92326030
61	negative regulation of execution phase of apoptosis (GO:1900118)	2.87564980
62	neuronal action potential propagation (GO:0019227)	2.85350790
63	positive regulation of glial cell differentiation (GO:0045687)	2.85171575
64	peptidyl-cysteine modification (GO:0018198)	2.81879396
65	organ growth (GO:0035265)	2.81418064
66	nerve growth factor signaling pathway (GO:0038180)	2.81166677
67	transmission of nerve impulse (GO:0019226)	2.79753124
68	amyloid precursor protein catabolic process (GO:0042987)	2.77707599
69	nucleotide transmembrane transport (GO:1901679)	2.77563858
70	negative regulation of JUN kinase activity (GO:0043508)	2.76564123
71	positive regulation of action potential (GO:0045760)	2.73085809
72	peripheral nervous system development (GO:0007422)	2.72574744
73	thioester biosynthetic process (GO:0035384)	2.71780461
74	acyl-CoA biosynthetic process (GO:0071616)	2.71780461
75	protein neddylation (GO:0045116)	2.71549542
76	enteric nervous system development (GO:0048484)	2.68752633
77	positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)	2.67520840
78	positive regulation of cellular amine metabolic process (GO:0033240)	2.67439293
79	glial cell development (GO:0021782)	2.66028083
80	positive regulation of gliogenesis (GO:0014015)	2.65862101
81	response to lead ion (GO:0010288)	2.65657477
82	leukocyte migration involved in inflammatory response (GO:0002523)	2.65425986
83	detection of temperature stimulus involved in sensory perception (GO:0050961)	2.63413265
84	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	2.63413265
85	Golgi to endosome transport (GO:0006895)	2.63276717
86	cranial nerve development (GO:0021545)	2.59261775
87	cellular response to epinephrine stimulus (GO:0071872)	2.59255947
88	iron coordination entity transport (GO:1901678)	2.58851064
89	heme transport (GO:0015886)	2.53373215
90	neural nucleus development (GO:0048857)	2.52535471
91	microtubule polymerization or depolymerization (GO:0031109)	2.51735946
92	neuronal ion channel clustering (GO:0045161)	2.50605626
93	negative regulation of macroautophagy (GO:0016242)	2.48479979
94	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.48256280
95	L-phenylalanine catabolic process (GO:0006559)	2.48256280
96	regulation of dopamine metabolic process (GO:0042053)	2.46153088
97	regulation of catecholamine metabolic process (GO:0042069)	2.46153088
98	negative regulation of axon extension (GO:0030517)	2.45827304
99	central nervous system myelination (GO:0022010)	12.7247653
100	axon ensheathment in central nervous system (GO:0032291)	12.7247653

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.39938942
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.83450935
3	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	2.75812235
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.63914593
5	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.34122690
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.33696753
7	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.31934529
8	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.22623684
9	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	2.13562451
10	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	2.02102119
11	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.00580647
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.99156796
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98441064
14	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.98334233
15	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.95049242
16	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.95005633
17	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.95005633
18	AR_21572438_ChIP-Seq_LNCaP_Human	1.90878450
19	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.89415612
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.87328076
21	VDR_22108803_ChIP-Seq_LS180_Human	1.85296715
22	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.84549484
23	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.82875404
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.81749290
25	* EZH2_27294783_Chip-Seq_ESCs_Mouse	1.76010930
26	* SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.75959143
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72634246
28	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.69848964
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.68208047
30	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.60052880
31	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.58646100
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.57653042
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55199641
34	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.53178829
35	DROSHA_22980978_ChIP-Seq_HELA_Human	1.52891537
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.48469698
37	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.47250515
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46357032
39	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.42217019
40	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40403462
41	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40239812
42	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.39548324
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.36017069
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.34652904
45	P300_19829295_ChIP-Seq_ESCs_Human	1.31766812
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29338704
47	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.28305683
48	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.27982651
49	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.25484556
50	FUS_26573619_Chip-Seq_HEK293_Human	1.23825021
51	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23553251
52	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.23068455
53	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.23068455
54	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.22985820
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21959075
56	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17356309
57	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.13880731
58	STAT3_23295773_ChIP-Seq_U87_Human	1.13760703
59	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.13707430
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12737822
61	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.09787368
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08967151
63	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.08821375
64	EOMES_21245162_ChIP-Seq_HESCs_Human	1.08457661
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07455816
66	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.07216153
67	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.06851000
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06656240
69	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04659937
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04362226
71	P300_18555785_Chip-Seq_ESCs_Mouse	1.03842630
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03362764
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02975494
74	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02388936
75	TCF4_23295773_ChIP-Seq_U87_Human	1.00219551
76	SMAD4_21799915_ChIP-Seq_A2780_Human	0.99919366
77	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99859500
78	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.99615050
79	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98481357
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97707022
81	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.97424848
82	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97170465
83	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97097784
84	TP53_16413492_ChIP-PET_HCT116_Human	0.96836735
85	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.96693039
86	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.95000305
87	IGF1R_20145208_ChIP-Seq_DFB_Human	0.94935047
88	* WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.94484429
89	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94364109
90	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94364109
91	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.93695703
92	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.93027305
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92861984
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.91823303
95	AHR_22903824_ChIP-Seq_MCF-7_Human	0.89166820
96	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.88869638
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.87863918
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.86477168
99	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.86068698
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.85980206

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000920_abnormal_myelination	5.64006488
2	MP0003880_abnormal_central_pattern	3.88116010
3	MP0003950_abnormal_plasma_membrane	3.70128688
4	MP0003690_abnormal_glial_cell	3.24128965
5	MP0004270_analgesia	3.21895204
6	MP0001529_abnormal_vocalization	2.90169698
7	MP0003329_amyloid_beta_deposits	2.77991723
8	MP0004885_abnormal_endolymph	2.74696683
9	MP0004742_abnormal_vestibular_system	2.63308680
10	MP0005171_absent_coat_pigmentation	2.63109492
11	MP0003136_yellow_coat_color	2.57659261
12	MP0002272_abnormal_nervous_system	2.56827845
13	MP0001486_abnormal_startle_reflex	2.52702121
14	MP0004142_abnormal_muscle_tone	2.44070942
15	MP0001905_abnormal_dopamine_level	2.41413052
16	MP0003634_abnormal_glial_cell	2.34926566
17	MP0002064_seizures	2.23896794
18	MP0001485_abnormal_pinna_reflex	2.21668284
19	MP0005409_darkened_coat_color	2.16726603
20	MP0005423_abnormal_somatic_nervous	2.15544337
21	MP0000778_abnormal_nervous_system	2.10707472
22	MP0004859_abnormal_synaptic_plasticity	2.01784970
23	MP0005410_abnormal_fertilization	2.00090792
24	MP0003632_abnormal_nervous_system	1.88711085
25	MP0002229_neurodegeneration	1.88494394
26	MP0010678_abnormal_skin_adnexa	1.83856180
27	MP0009046_muscle_twitch	1.79849875
28	MP0004043_abnormal_pH_regulation	1.76359300
29	MP0009745_abnormal_behavioral_response	1.73728086
30	MP0003635_abnormal_synaptic_transmissio	1.73255617
31	MP0005451_abnormal_body_composition	1.67592373
32	MP0000383_abnormal_hair_follicle	1.64376989
33	MP0002734_abnormal_mechanical_nocicepti	1.61370661
34	MP0004381_abnormal_hair_follicle	1.60419351
35	MP0000462_abnormal_digestive_system	1.56942076
36	MP0003631_nervous_system_phenotype	1.53235257
37	MP0005551_abnormal_eye_electrophysiolog	1.43980599
38	MP0000955_abnormal_spinal_cord	1.43056863
39	MP0000604_amyloidosis	1.42431031
40	MP0003806_abnormal_nucleotide_metabolis	1.41611196
41	MP0000566_synostosis	1.38747835
42	MP0008260_abnormal_autophagy	1.38411149
43	MP0004134_abnormal_chest_morphology	1.37625868
44	MP0003633_abnormal_nervous_system	1.36053714
45	MP0002572_abnormal_emotion/affect_behav	1.35180568
46	MP0002882_abnormal_neuron_morphology	1.34108353
47	MP0008569_lethality_at_weaning	1.32767136
48	MP0001440_abnormal_grooming_behavior	1.27617058
49	MP0003195_calcinosis	1.27283517
50	MP0002063_abnormal_learning/memory/cond	1.26499700
51	MP0002066_abnormal_motor_capabilities/c	1.24238329
52	MP0001963_abnormal_hearing_physiology	1.24206757
53	MP0001970_abnormal_pain_threshold	1.21325480
54	MP0004147_increased_porphyrin_level	1.20735212
55	MP0002067_abnormal_sensory_capabilities	1.17732631
56	MP0002752_abnormal_somatic_nervous	1.15467342
57	MP0001346_abnormal_lacrimal_gland	1.14928875
58	MP0004924_abnormal_behavior	1.14804212
59	MP0005386_behavior/neurological_phenoty	1.14804212
60	MP0005623_abnormal_meninges_morphology	1.09584942
61	MP0000747_muscle_weakness	1.05195472
62	MP0001299_abnormal_eye_distance/	1.05114574
63	MP0000647_abnormal_sebaceous_gland	1.04362006
64	MP0003938_abnormal_ear_development	1.04306789
65	MP0005195_abnormal_posterior_eye	1.00723281
66	MP0001851_eye_inflammation	0.93654075
67	MP0001177_atelectasis	0.93330632
68	MP0002733_abnormal_thermal_nociception	0.92441784
69	MP0001661_extended_life_span	0.90984500
70	MP0004145_abnormal_muscle_electrophysio	0.90695498
71	MP0005058_abnormal_lysosome_morphology	0.89588467
72	MP0000762_abnormal_tongue_morphology	0.85246459
73	MP0000026_abnormal_inner_ear	0.83373677
74	MP0003937_abnormal_limbs/digits/tail_de	0.82795503
75	MP0002295_abnormal_pulmonary_circulatio	0.81853989
76	MP0002822_catalepsy	0.81335691
77	MP0002152_abnormal_brain_morphology	0.79763527
78	MP0001968_abnormal_touch/_nociception	0.79041122
79	MP0005408_hypopigmentation	0.76866153
80	MP0000579_abnormal_nail_morphology	0.75737436
81	MP0006082_CNS_inflammation	0.75569809
82	MP0005253_abnormal_eye_physiology	0.74596084
83	MP0001348_abnormal_lacrimal_gland	0.72141862
84	MP0002184_abnormal_innervation	0.71069970
85	MP0002735_abnormal_chemical_nociception	0.70675600
86	MP0001501_abnormal_sleep_pattern	0.68375030
87	MP0001502_abnormal_circadian_rhythm	0.67217306
88	MP0006072_abnormal_retinal_apoptosis	0.66766567
89	MP0003137_abnormal_impulse_conducting	0.65839801
90	MP0004036_abnormal_muscle_relaxation	0.64901477
91	MP0000467_abnormal_esophagus_morphology	0.62177538
92	MP0000003_abnormal_adipose_tissue	0.61970354
93	MP0002736_abnormal_nociception_after	0.61454535
94	MP0002557_abnormal_social/conspecific_i	0.61367439
95	MP0008438_abnormal_cutaneous_collagen	0.61032949
96	MP0002133_abnormal_respiratory_system	0.60783939
97	MP0005388_respiratory_system_phenotype	0.60783939
98	MP0002090_abnormal_vision	0.60607110
99	MP0001340_abnormal_eyelid_morphology	0.57912563
100	MP0003656_abnormal_erythrocyte_physiolo	0.57675256

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Degeneration of the lateral corticospinal tracts (HP:0002314)	6.95736132
2	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	6.95736132
3	Neurofibrillary tangles (HP:0002185)	6.28904890
4	Abnormality of the corticospinal tract (HP:0002492)	5.13108470
5	Parakeratosis (HP:0001036)	4.95159944
6	Peripheral hypomyelination (HP:0007182)	4.63413602
7	Cerebral inclusion bodies (HP:0100314)	4.46184981
8	Sensory axonal neuropathy (HP:0003390)	4.41959841
9	Onion bulb formation (HP:0003383)	3.96789800
10	Insidious onset (HP:0003587)	3.78842754
11	Termporal pattern (HP:0011008)	3.78842754
12	Supranuclear gaze palsy (HP:0000605)	3.72173774
13	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.70850859
14	Cerebral hypomyelination (HP:0006808)	3.67703969
15	Spastic gait (HP:0002064)	3.65464076
16	Abnormal auditory evoked potentials (HP:0006958)	3.49676606
17	Alacrima (HP:0000522)	3.25649221
18	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.16345645
19	Intention tremor (HP:0002080)	3.13669782
20	Dysmetria (HP:0001310)	3.12432538
21	Ankle clonus (HP:0011448)	3.04869826
22	Retinal dysplasia (HP:0007973)	3.04866507
23	Leukodystrophy (HP:0002415)	3.00901678
24	Myokymia (HP:0002411)	2.97732603
25	Increased serum pyruvate (HP:0003542)	2.93165216
26	Abnormality of glycolysis (HP:0004366)	2.93165216
27	Segmental peripheral demyelination/remyelination (HP:0003481)	2.87248384
28	Slow saccadic eye movements (HP:0000514)	2.85870235
29	Scanning speech (HP:0002168)	2.85098022
30	Anteriorly placed anus (HP:0001545)	2.81503356
31	Congenital ichthyosiform erythroderma (HP:0007431)	2.69389973
32	Absent septum pellucidum (HP:0001331)	2.67332519
33	Clumsiness (HP:0002312)	2.58713169
34	Hypoplastic pelvis (HP:0008839)	2.58462250
35	Stridor (HP:0010307)	2.57424957
36	Decreased lacrimation (HP:0000633)	2.56482320
37	Thickened helices (HP:0000391)	2.56477225
38	Premature skin wrinkling (HP:0100678)	2.55380824
39	Cerebral hemorrhage (HP:0001342)	2.53211445
40	Split foot (HP:0001839)	2.51079236
41	Autoamputation (HP:0001218)	2.49646502
42	CNS hypomyelination (HP:0003429)	2.43156710
43	Spastic paraparesis (HP:0002313)	2.39795270
44	Increased circulating renin level (HP:0000848)	2.39410727
45	Morphological abnormality of the inner ear (HP:0011390)	2.39028306
46	Metabolic alkalosis (HP:0200114)	2.30826427
47	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.29322794
48	Aplasia involving bones of the upper limbs (HP:0009823)	2.29144843
49	Aplasia of the phalanges of the hand (HP:0009802)	2.29144843
50	Aplasia involving bones of the extremities (HP:0009825)	2.29144843
51	Abnormality of the septum pellucidum (HP:0007375)	2.27572721
52	Coronal craniosynostosis (HP:0004440)	2.25604477
53	Pheochromocytoma (HP:0002666)	2.23527820
54	White forelock (HP:0002211)	2.22604974
55	Lower limb muscle weakness (HP:0007340)	2.22529311
56	Akinesia (HP:0002304)	2.22252209
57	Patchy hypopigmentation of hair (HP:0011365)	2.19694555
58	Foot dorsiflexor weakness (HP:0009027)	2.18016043
59	Hypoplasia of the iris (HP:0007676)	2.16054098
60	Spastic tetraparesis (HP:0001285)	2.14514263
61	Axonal loss (HP:0003447)	2.13043008
62	Hepatosplenomegaly (HP:0001433)	2.11668627
63	Megalencephaly (HP:0001355)	2.08855209
64	Hypomagnesemia (HP:0002917)	2.04407095
65	Partial duplication of thumb phalanx (HP:0009944)	2.04115827
66	Hypokalemic alkalosis (HP:0001949)	2.03937087
67	Humeroradial synostosis (HP:0003041)	2.02156830
68	Synostosis involving the elbow (HP:0003938)	2.02156830
69	Decreased motor nerve conduction velocity (HP:0003431)	2.01884153
70	Muscle fiber splitting (HP:0003555)	2.01396606
71	Cupped ear (HP:0000378)	2.01299121
72	Hypophosphatemic rickets (HP:0004912)	1.97380285
73	Abnormality of the foot musculature (HP:0001436)	1.97338174
74	Partial agenesis of the corpus callosum (HP:0001338)	1.96796937
75	Renal Fanconi syndrome (HP:0001994)	1.95030322
76	Poor speech (HP:0002465)	1.94152534
77	Neuroendocrine neoplasm (HP:0100634)	1.93135425
78	Clonus (HP:0002169)	1.92062300
79	Methylmalonic acidemia (HP:0002912)	1.91540652
80	Infantile muscular hypotonia (HP:0008947)	1.90473538
81	Abnormality of the middle phalanges of the toes (HP:0010183)	1.89146671
82	Esophageal atresia (HP:0002032)	1.86311235
83	Bowel incontinence (HP:0002607)	1.86032993
84	3-Methylglutaconic aciduria (HP:0003535)	1.85107823
85	Morphological abnormality of the pyramidal tract (HP:0002062)	1.84456065
86	Action tremor (HP:0002345)	1.84116018
87	Urinary incontinence (HP:0000020)	1.83740573
88	Gowers sign (HP:0003391)	1.83001506
89	Choreoathetosis (HP:0001266)	1.82374330
90	Urinary urgency (HP:0000012)	1.81617838
91	Hammertoe (HP:0001765)	1.81541696
92	Paraparesis (HP:0002385)	1.80425182
93	Focal motor seizures (HP:0011153)	1.78111646
94	Abnormal large intestine physiology (HP:0012700)	1.74081455
95	Erythroderma (HP:0001019)	1.72374098
96	Partial duplication of the phalanx of hand (HP:0009999)	1.70137394
97	Distal sensory impairment (HP:0002936)	1.70108687
98	Adrenal hypoplasia (HP:0000835)	1.69207441
99	Diaphragmatic weakness (HP:0009113)	1.67768873
100	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.66908027

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK39	6.29152949
2	OXSR1	4.55851319
3	EPHB1	3.61097443
4	PKN1	2.76747431
5	PBK	2.74475818
6	MAPKAPK5	2.67575032
7	BCR	2.67317417
8	CDK19	2.47053542
9	WNK4	2.43414839
10	MET	2.36629883
11	FGFR2	2.24203884
12	WNK1	2.06302513
13	TESK2	1.91811824
14	LIMK1	1.91733705
15	UHMK1	1.85264633
16	TNIK	1.75366535
17	PNCK	1.72860584
18	CSNK1G3	1.71653945
19	CAMK2B	1.69923922
20	CSNK1A1L	1.66709789
21	NEK6	1.63185432
22	NTRK1	1.57576473
23	MST4	1.50974333
24	ROCK2	1.49777821
25	ICK	1.44252706
26	CLK1	1.43615001
27	FGR	1.42964088
28	CAMK2D	1.39589555
29	CSNK1G1	1.35400214
30	CASK	1.33814379
31	CSNK1G2	1.26466109
32	SGK223	1.23577393
33	SGK494	1.23577393
34	PAK6	1.21648906
35	EPHA4	1.14299242
36	CAMK2G	1.09648574
37	PRPF4B	1.08287684
38	MUSK	1.03806381
39	DYRK2	0.99777571
40	MARK1	0.97154460
41	TYRO3	0.91331926
42	CAMK2A	0.88216495
43	MARK2	0.85183710
44	CDK5	0.83211141
45	CDK14	0.82145672
46	PAK3	0.81976502
47	PRKCQ	0.80101403
48	MAPK15	0.77540624
49	PRKD1	0.76509614
50	CDK15	0.72622502
51	PRKCE	0.68557240
52	CDK18	0.67313581
53	ERBB4	0.67153043
54	BMPR1B	0.66510960
55	IRAK2	0.64916863
56	CDK11A	0.64663372
57	PHKG2	0.63960605
58	PHKG1	0.63960605
59	RPS6KA5	0.62938804
60	ARAF	0.62733107
61	PDPK1	0.58233847
62	FYN	0.53656320
63	CSNK1D	0.51051715
64	TRPM7	0.49754232
65	PRKG1	0.48854103
66	GSK3A	0.48719615
67	NTRK2	0.48650265
68	MAPK13	0.46931149
69	STK11	0.43433171
70	CSNK1A1	0.43029282
71	PRKACB	0.42270179
72	MAP3K13	0.42152385
73	MKNK1	0.41616761
74	MAP2K2	0.41596951
75	KSR2	0.41023091
76	FES	0.38146549
77	CAMK1G	0.37027495
78	PIK3CA	0.37009654
79	DMPK	0.36872515
80	PRKCH	0.36751854
81	PAK1	0.35894148
82	ADRBK2	0.34865144
83	PINK1	0.32979805
84	BMX	0.32910135
85	MAPK7	0.32731231
86	BMPR2	0.31669753
87	PDGFRB	0.31646036
88	PTK2B	0.30970947
89	OBSCN	0.30904518
90	GRK7	0.30141555
91	DAPK3	0.29836699
92	PRKACA	0.29734657
93	INSR	0.28148989
94	DYRK1A	0.26864418
95	PRKD3	0.26430129
96	PDK1	0.25197944
97	ITK	0.24292183
98	CSNK1E	0.23136165
99	SGK1	0.22828916
100	MAPK10	0.22587053

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	5.36818111
2	Steroid biosynthesis_Homo sapiens_hsa00100	4.58443560
3	Fatty acid elongation_Homo sapiens_hsa00062	4.50186275
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.30614458
5	Ether lipid metabolism_Homo sapiens_hsa00565	3.19893865
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.16100450
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.52874742
8	Sulfur metabolism_Homo sapiens_hsa00920	2.03907307
9	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.02872611
10	Protein export_Homo sapiens_hsa03060	1.94692517
11	Oxidative phosphorylation_Homo sapiens_hsa00190	1.85981224
12	Histidine metabolism_Homo sapiens_hsa00340	1.84333393
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.84327891
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.83742011
15	Sphingolipid metabolism_Homo sapiens_hsa00600	1.82315575
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68493952
17	Axon guidance_Homo sapiens_hsa04360	1.67694436
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.50838228
19	GABAergic synapse_Homo sapiens_hsa04727	1.44037002
20	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.39650160
21	Parkinsons disease_Homo sapiens_hsa05012	1.36057161
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.35712486
23	Butanoate metabolism_Homo sapiens_hsa00650	1.35305882
24	Serotonergic synapse_Homo sapiens_hsa04726	1.33439336
25	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.27015901
26	Alzheimers disease_Homo sapiens_hsa05010	1.25851950
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.12775968
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.11822280
29	Morphine addiction_Homo sapiens_hsa05032	1.10559488
30	Renal cell carcinoma_Homo sapiens_hsa05211	1.08628609
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.06236260
32	Long-term depression_Homo sapiens_hsa04730	1.05199063
33	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.91675661
34	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91221919
35	Vibrio cholerae infection_Homo sapiens_hsa05110	0.88160900
36	Tight junction_Homo sapiens_hsa04530	0.86962412
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84757839
38	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.84397190
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80699702
40	Cocaine addiction_Homo sapiens_hsa05030	0.80496233
41	Circadian entrainment_Homo sapiens_hsa04713	0.78702852
42	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75380230
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72845886
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.72486629
45	Ras signaling pathway_Homo sapiens_hsa04014	0.71494038
46	Salivary secretion_Homo sapiens_hsa04970	0.71268520
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69183531
48	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.68813056
49	Folate biosynthesis_Homo sapiens_hsa00790	0.68734281
50	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.68336708
51	Phototransduction_Homo sapiens_hsa04744	0.67765834
52	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.67157701
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.66381583
54	Endocytosis_Homo sapiens_hsa04144	0.65815193
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.65253208
56	Nicotine addiction_Homo sapiens_hsa05033	0.64947962
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.64756457
58	Gastric acid secretion_Homo sapiens_hsa04971	0.64455090
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.64132330
60	Glutathione metabolism_Homo sapiens_hsa00480	0.63472030
61	Propanoate metabolism_Homo sapiens_hsa00640	0.62943483
62	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.61309914
63	Cholinergic synapse_Homo sapiens_hsa04725	0.60703103
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.59933420
65	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.59616077
66	Mineral absorption_Homo sapiens_hsa04978	0.57111684
67	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.57104525
68	Lysosome_Homo sapiens_hsa04142	0.57098537
69	Huntingtons disease_Homo sapiens_hsa05016	0.56449824
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55566822
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55550231
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55064858
73	Pancreatic secretion_Homo sapiens_hsa04972	0.51712331
74	ErbB signaling pathway_Homo sapiens_hsa04012	0.49959871
75	Phagosome_Homo sapiens_hsa04145	0.47185076
76	Peroxisome_Homo sapiens_hsa04146	0.47098795
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46409253
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46393503
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42814066
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.42262152
81	Taste transduction_Homo sapiens_hsa04742	0.41413451
82	Renin secretion_Homo sapiens_hsa04924	0.40723712
83	Metabolic pathways_Homo sapiens_hsa01100	0.39896536
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39638397
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38880174
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37430776
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37215602
88	Gap junction_Homo sapiens_hsa04540	0.36735504
89	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.35558279
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.32058766
91	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.30234967
92	Prion diseases_Homo sapiens_hsa05020	0.30004966
93	Amphetamine addiction_Homo sapiens_hsa05031	0.29201858
94	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.29059368
95	Choline metabolism in cancer_Homo sapiens_hsa05231	0.28783229
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28557329
97	Retinol metabolism_Homo sapiens_hsa00830	0.26660325
98	ECM-receptor interaction_Homo sapiens_hsa04512	0.25985937
99	Regulation of autophagy_Homo sapiens_hsa04140	0.25143792
100	Malaria_Homo sapiens_hsa05144	0.24879068

TMEM88B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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