TMEM89

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.72469447
2multicellular organism reproduction (GO:0032504)9.61043819
3spermatid development (GO:0007286)9.44957414
4plasma membrane fusion (GO:0045026)9.43253077
5motile cilium assembly (GO:0044458)9.32250017
6epithelial cilium movement (GO:0003351)9.27809090
7cilium or flagellum-dependent cell motility (GO:0001539)8.79760840
8regulation of cellular extravasation (GO:0002691)8.62474046
9pyrimidine-containing compound transmembrane transport (GO:0072531)8.53763924
10reproduction (GO:0000003)8.34672669
11cilium movement (GO:0003341)7.71087145
12regulation of cilium movement (GO:0003352)7.51394815
13synaptonemal complex organization (GO:0070193)7.07165641
14piRNA metabolic process (GO:0034587)7.04431616
15negative regulation of inclusion body assembly (GO:0090084)7.02250457
16sperm capacitation (GO:0048240)7.02243570
17male meiosis (GO:0007140)6.95940387
18synaptonemal complex assembly (GO:0007130)6.89854867
19chaperone-mediated protein transport (GO:0072321)6.88405267
20single fertilization (GO:0007338)6.88201715
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.82779191
22organic cation transport (GO:0015695)6.78595837
23spermatogenesis (GO:0007283)6.72873990
24male gamete generation (GO:0048232)6.70067344
25cytoplasmic mRNA processing body assembly (GO:0033962)6.48900569
26cellular response to exogenous dsRNA (GO:0071360)6.48002097
27nucleotide transmembrane transport (GO:1901679)6.29470694
28gamete generation (GO:0007276)6.14693410
29fertilization (GO:0009566)6.03160317
30protein-chromophore linkage (GO:0018298)5.79768594
31regulation of inclusion body assembly (GO:0090083)5.77271603
32microtubule depolymerization (GO:0007019)5.61088952
33ventricular system development (GO:0021591)5.45989723
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.41268950
35chromosome condensation (GO:0030261)5.39751532
36germ cell development (GO:0007281)5.33664296
37calcium ion-dependent exocytosis (GO:0017156)5.32621023
38DNA packaging (GO:0006323)5.19864099
39microtubule severing (GO:0051013)5.07011134
40seminiferous tubule development (GO:0072520)5.02672293
41retrograde transport, vesicle recycling within Golgi (GO:0000301)4.99885011
42cell recognition (GO:0008037)4.93750436
43negative regulation of T-helper cell differentiation (GO:0045623)4.90216657
44negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.90216657
45negative regulation of leukocyte migration (GO:0002686)4.87311023
46male meiosis I (GO:0007141)4.84751176
47multicellular organismal reproductive process (GO:0048609)4.78975163
48auditory receptor cell differentiation (GO:0042491)4.66363084
49retinal cone cell development (GO:0046549)4.65829956
50DNA damage response, detection of DNA damage (GO:0042769)4.58732118
51DNA methylation involved in gamete generation (GO:0043046)4.58478733
52post-embryonic morphogenesis (GO:0009886)4.57790125
53galactose metabolic process (GO:0006012)4.55573303
54chromosome organization involved in meiosis (GO:0070192)4.51984893
55regulation of microtubule-based movement (GO:0060632)4.50209896
56positive regulation of Cdc42 GTPase activity (GO:0043089)4.41809833
57cellular response to prostaglandin stimulus (GO:0071379)4.41658849
58sequestering of actin monomers (GO:0042989)4.38110218
59glycerol ether metabolic process (GO:0006662)4.37594517
60lateral ventricle development (GO:0021670)4.27751477
61left/right pattern formation (GO:0060972)4.23118566
62meiotic nuclear division (GO:0007126)4.22552616
63heterochromatin organization (GO:0070828)4.19113109
64spermatid nucleus differentiation (GO:0007289)4.17032435
65anatomical structure regression (GO:0060033)4.06665584
66cellular response to interferon-beta (GO:0035458)4.06036415
67ether metabolic process (GO:0018904)4.02668545
68response to parathyroid hormone (GO:0071107)3.97882047
69sexual reproduction (GO:0019953)3.92373645
70multicellular organismal development (GO:0007275)3.92250176
71histone H3-K9 demethylation (GO:0033169)3.88159700
72urogenital system development (GO:0001655)3.87731966
73sulfate transmembrane transport (GO:1902358)3.85539175
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.85000494
75negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.80283783
76RNA destabilization (GO:0050779)3.75406357
77meiosis I (GO:0007127)3.74973251
78ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.74888600
79regulation of helicase activity (GO:0051095)3.73253414
80protein import into peroxisome matrix (GO:0016558)3.72723702
81protein localization to cilium (GO:0061512)3.71997907
82positive regulation of natural killer cell differentiation (GO:0032825)3.67491952
83genitalia morphogenesis (GO:0035112)3.66654933
84chaperone-mediated protein complex assembly (GO:0051131)3.65897697
85RNA localization (GO:0006403)3.63742291
86negative regulation of B cell proliferation (GO:0030889)3.62798784
87regulation of spindle checkpoint (GO:0090231)3.58443954
88sex differentiation (GO:0007548)3.54408597
89negative regulation of alpha-beta T cell differentiation (GO:0046639)3.54138147
90cellular response to dsRNA (GO:0071359)3.53482432
91regulation of germinal center formation (GO:0002634)3.52418348
92pseudouridine synthesis (GO:0001522)3.51789379
93gonadal mesoderm development (GO:0007506)3.50287213
94meiotic cell cycle (GO:0051321)3.49621899
95protein polyglutamylation (GO:0018095)3.47773585
96ribosomal large subunit biogenesis (GO:0042273)3.45485594
97cellular sodium ion homeostasis (GO:0006883)3.45397689
98RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.42843115
99amino-acid betaine transport (GO:0015838)3.41510039
100carnitine transport (GO:0015879)3.41510039
101tRNA processing (GO:0008033)3.41393209
102ribosomal small subunit biogenesis (GO:0042274)3.41254611
103interferon-gamma secretion (GO:0072643)3.36695189
104dendritic spine morphogenesis (GO:0060997)3.35417721
105viral transcription (GO:0019083)3.35417013
106skeletal muscle organ development (GO:0060538)3.33044990
107nucleoside diphosphate phosphorylation (GO:0006165)3.31820439
108nucleotide transport (GO:0006862)3.31645291
109tooth mineralization (GO:0034505)3.30263508
110GTP biosynthetic process (GO:0006183)3.30048568
111protein targeting to peroxisome (GO:0006625)3.27975425
112establishment of protein localization to peroxisome (GO:0072663)3.27975425
113protein localization to peroxisome (GO:0072662)3.27975425
114response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25488328
115response to host (GO:0075136)3.25488328
116response to host defenses (GO:0052200)3.25488328
117carnitine transmembrane transport (GO:1902603)3.25024251
118single strand break repair (GO:0000012)3.24607878
119kynurenine metabolic process (GO:0070189)3.21747951
120protein K11-linked deubiquitination (GO:0035871)3.21359357
121protein autoprocessing (GO:0016540)3.20314893
122translational termination (GO:0006415)3.19025754
123positive regulation of dendrite morphogenesis (GO:0050775)3.17967119
124viral protein processing (GO:0019082)3.17940277
125rRNA modification (GO:0000154)3.14649745
126mRNA cleavage (GO:0006379)3.14592637
127positive regulation of macrophage activation (GO:0043032)3.13728268
128chromatin assembly (GO:0031497)3.10322272
129peroxisomal transport (GO:0043574)3.08706633
130axoneme assembly (GO:0035082)3.08231189
131DNA-dependent DNA replication (GO:0006261)3.07418172
132L-ascorbic acid metabolic process (GO:0019852)3.06189320
133short-term memory (GO:0007614)3.05588000
134negative regulation of gene silencing (GO:0060969)3.04750063
135hair cell differentiation (GO:0035315)3.04508146
136negative regulation of protein tyrosine kinase activity (GO:0061099)3.04117348
137sulfate transport (GO:0008272)3.03428776
138positive regulation of CREB transcription factor activity (GO:0032793)3.01908116
139microtubule polymerization or depolymerization (GO:0031109)3.01659685
140negative regulation of T cell proliferation (GO:0042130)2.99986887
141positive regulation of cAMP-mediated signaling (GO:0043950)2.99841382
142response to prostaglandin E (GO:0034695)2.97939288
143positive regulation of toll-like receptor signaling pathway (GO:0034123)2.97303516
144protein refolding (GO:0042026)2.96370212
145protoporphyrinogen IX biosynthetic process (GO:0006782)2.94417636
146indolalkylamine catabolic process (GO:0046218)2.94344209
147tryptophan catabolic process (GO:0006569)2.94344209
148indole-containing compound catabolic process (GO:0042436)2.94344209
149nucleus organization (GO:0006997)2.92778356
150rRNA methylation (GO:0031167)2.92696724
151SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90380570
152cilium organization (GO:0044782)2.89829334
153cotranslational protein targeting to membrane (GO:0006613)2.89616001
154protein targeting to ER (GO:0045047)2.88968811
155UTP biosynthetic process (GO:0006228)2.88955241
156pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87439380
157base-excision repair, AP site formation (GO:0006285)2.86955457
158mitotic sister chromatid cohesion (GO:0007064)2.86762578
159glycolytic process (GO:0006096)2.86595166
160positive regulation of viral genome replication (GO:0045070)2.85162597
161keratan sulfate biosynthetic process (GO:0018146)2.84914535
162pyrimidine nucleotide catabolic process (GO:0006244)2.84461251
163negative regulation of alpha-beta T cell activation (GO:0046636)2.82738860
164membrane protein intracellular domain proteolysis (GO:0031293)2.79465692
165adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.78579480
166protein targeting to Golgi (GO:0000042)2.77409290
167cellular component assembly involved in morphogenesis (GO:0010927)2.77127050
168somite development (GO:0061053)2.76662540
169alditol metabolic process (GO:0019400)2.76232019
170cilium assembly (GO:0042384)2.75322335
171UTP metabolic process (GO:0046051)2.71764401
172intraciliary transport (GO:0042073)2.69868810
173microtubule-based movement (GO:0007018)2.68202651
174negative regulation of organelle assembly (GO:1902116)2.67277109
175lactate metabolic process (GO:0006089)2.62576792
176phospholipid translocation (GO:0045332)2.57466359
177lipid translocation (GO:0034204)2.57466359
178meiotic cell cycle process (GO:1903046)2.50893246
179protein-DNA complex disassembly (GO:0032986)2.50007869
180nucleosome disassembly (GO:0006337)2.50007869
181polyol catabolic process (GO:0046174)2.49262754
182synapsis (GO:0007129)2.48505544
183peptidyl-glutamic acid modification (GO:0018200)2.48432050
184sperm motility (GO:0030317)13.2484647
185cell wall macromolecule catabolic process (GO:0016998)13.0910366
186cell wall macromolecule metabolic process (GO:0044036)13.0910366
187fusion of sperm to egg plasma membrane (GO:0007342)12.4616136
188acrosome reaction (GO:0007340)12.1474250
189acrosome assembly (GO:0001675)11.4590241
190sperm-egg recognition (GO:0035036)11.2355378
191tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)10.7579709
192RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)10.7579709
193binding of sperm to zona pellucida (GO:0007339)10.4775693
194cell-cell recognition (GO:0009988)10.0447905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.39307960
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.75546777
3EZH2_22144423_ChIP-Seq_EOC_Human4.61358252
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.70605997
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.70318963
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.60634446
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.38146603
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.22482070
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.90496712
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.86957396
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.84056072
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.53681976
13ZNF274_21170338_ChIP-Seq_K562_Hela2.34796874
14YY1_21170310_ChIP-Seq_MESCs_Mouse2.32486188
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19857810
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.14806605
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.11671715
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.10036878
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08008292
20VDR_22108803_ChIP-Seq_LS180_Human2.04576515
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02020971
22CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.93302732
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.89388840
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89341846
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.87942836
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.82660997
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76023131
28ERA_21632823_ChIP-Seq_H3396_Human1.70735833
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70192897
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69189381
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65884523
32STAT1_17558387_ChIP-Seq_HELA_Human1.64024075
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63710832
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.61021768
35CIITA_25753668_ChIP-Seq_RAJI_Human1.61008182
36AR_21572438_ChIP-Seq_LNCaP_Human1.58473419
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57448882
38* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.55758322
39* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55508302
40SOX2_22085726_ChIP-Seq_NPCs_Mouse1.54026368
41GATA3_21867929_ChIP-Seq_CD8_Mouse1.52748104
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.52363678
43LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51075363
44CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.48254813
45SPI1_20517297_ChIP-Seq_HL60_Human1.46934224
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46426459
47GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44643603
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44633990
49FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.43329811
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42940560
51TAL1_26923725_Chip-Seq_HPCs_Mouse1.41491338
52TP53_16413492_ChIP-PET_HCT116_Human1.38909013
53SA1_27219007_Chip-Seq_Bcells_Human1.38652624
54CBP_20019798_ChIP-Seq_JUKART_Human1.38642502
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38642502
56REST_21632747_ChIP-Seq_MESCs_Mouse1.38207364
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37386957
58SOX2_18692474_ChIP-Seq_MEFs_Mouse1.34550533
59BCL6_27268052_Chip-Seq_Bcells_Human1.33169793
60IGF1R_20145208_ChIP-Seq_DFB_Human1.32508720
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30682040
62LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30114096
63E2F1_20622854_ChIP-Seq_HELA_Human1.28815175
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.28569844
65P53_21459846_ChIP-Seq_SAOS-2_Human1.28313719
66KDM2B_26808549_Chip-Seq_REH_Human1.28154049
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27270641
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24905578
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24499207
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.23558793
71DROSHA_22980978_ChIP-Seq_HELA_Human1.21561260
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19918057
73GF1_26923725_Chip-Seq_HPCs_Mouse1.18222084
74SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18101105
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18027396
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17572585
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17506935
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17267093
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17132296
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15590614
81ERG_20517297_ChIP-Seq_VCAP_Human1.14864015
82SMRT_27268052_Chip-Seq_Bcells_Human1.14578018
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14259769
84CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13805550
85SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13647445
86FUS_26573619_Chip-Seq_HEK293_Human1.13103756
87RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12174481
88MYC_27129775_Chip-Seq_CORNEA_Mouse1.11915398
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11705724
90XRN2_22483619_ChIP-Seq_HELA_Human1.11126522
91CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10968119
92* SPI1_26923725_Chip-Seq_HPCs_Mouse1.10890606
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10578452
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10102436
95BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.09686553
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07295907
97TET1_21451524_ChIP-Seq_MESCs_Mouse1.06503044
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.06391117
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06328008
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06328008
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.06266314
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05715836
103YY1_22570637_ChIP-Seq_MALME-3M_Human1.05690357
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.05606848
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05169515
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05066622
107GATA3_21867929_ChIP-Seq_TH1_Mouse1.04951745
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.04534263
109CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03848127
110RARA_24833708_ChIP-Seq_LIVER_Mouse1.03658933
111ESET_19884257_ChIP-Seq_ESCs_Mouse1.03450360
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03258244
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03257979
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03168929
115RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02517891
116RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01703575
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00893987
118SOX11_22085726_ChIP-Seq_ESNs_Mouse1.00690243
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00541491
120CTCF_20526341_ChIP-Seq_ESCs_Human0.99328271
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99318727
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99112007
123LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98709688
124P53_22387025_ChIP-Seq_ESCs_Mouse0.98360259
125VDR_23849224_ChIP-Seq_CD4+_Human0.96854529
126EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96033926
127FLI1_21867929_ChIP-Seq_CD8_Mouse0.95300283
128OCT4_20526341_ChIP-Seq_ESCs_Human0.94620929
129KDM5A_27292631_Chip-Seq_BREAST_Human0.94316932
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.93859827
131OCT4_18555785_Chip-Seq_ESCs_Mouse0.93838387
132RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93783278
133KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93731987
134* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92966114
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92748175
136SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91864578
137GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91752204
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91425126
139FOXP1_21924763_ChIP-Seq_HESCs_Human0.91243930
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91179209
141PHF8_20622854_ChIP-Seq_HELA_Human0.90834906
142BCOR_27268052_Chip-Seq_Bcells_Human0.90749969
143PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90689986
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90667509
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.90406429
146NFYB_21822215_ChIP-Seq_K562_Human0.90258882
147ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90153871
148NANOG_19829295_ChIP-Seq_ESCs_Human0.89943806
149SOX2_19829295_ChIP-Seq_ESCs_Human0.89943806
150OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89736915
151PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89518821
152CTCF_27219007_Chip-Seq_Bcells_Human0.88114673
153HTT_18923047_ChIP-ChIP_STHdh_Human0.87751930
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87643837
155NANOG_20526341_ChIP-Seq_ESCs_Human0.87573118
156STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87389800
157ELF1_20517297_ChIP-Seq_JURKAT_Human0.87285717
158EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87078036
159P300_27268052_Chip-Seq_Bcells_Human0.86465769
160CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85472228
161POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83140443
162SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82563305
163ERG_21242973_ChIP-ChIP_JURKAT_Human0.82262662
164ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81540228
165EZH2_27304074_Chip-Seq_ESCs_Mouse0.80371685
166E2F1_17053090_ChIP-ChIP_MCF-7_Human0.80296107
167AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79590899
168TAF2_19829295_ChIP-Seq_ESCs_Human0.79322119
169SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79247575
170OCT4_19829295_ChIP-Seq_ESCs_Human0.77777761
171TTF2_22483619_ChIP-Seq_HELA_Human0.77677207
172FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.77546883
173FOXA1_25329375_ChIP-Seq_VCAP_Human0.76443224
174FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76443224
175SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75789477
176LXR_22292898_ChIP-Seq_THP-1_Human0.73782690
177PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.73539190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.05872625
2MP0003698_abnormal_male_reproductive5.75464843
3MP0001929_abnormal_gametogenesis5.23904338
4MP0003122_maternal_imprinting5.09853676
5MP0005409_darkened_coat_color4.18092103
6MP0003123_paternal_imprinting4.01658416
7MP0009379_abnormal_foot_pigmentation4.00192887
8MP0008877_abnormal_DNA_methylation3.46553342
9MP0002638_abnormal_pupillary_reflex3.19329591
10MP0002210_abnormal_sex_determination3.11459637
11MP0002161_abnormal_fertility/fecundity3.07395180
12MP0003787_abnormal_imprinting2.95540626
13MP0001145_abnormal_male_reproductive2.71641989
14MP0005670_abnormal_white_adipose2.60348613
15MP0009780_abnormal_chondrocyte_physiolo2.51608227
16MP0002653_abnormal_ependyma_morphology2.35611075
17MP0000653_abnormal_sex_gland2.32081947
18MP0002102_abnormal_ear_morphology2.30826198
19MP0004142_abnormal_muscle_tone2.15267240
20MP0005365_abnormal_bile_salt2.13772194
21MP0000685_abnormal_immune_system2.06587950
22MP0005410_abnormal_fertilization16.3475652
23MP0003136_yellow_coat_color1.97204360
24MP0003121_genomic_imprinting1.93515990
25MP0005083_abnormal_biliary_tract1.88579120
26MP0002160_abnormal_reproductive_system1.83778750
27MP0003646_muscle_fatigue1.79138051
28MP0001958_emphysema1.71071785
29MP0000678_abnormal_parathyroid_gland1.69644847
30MP0000049_abnormal_middle_ear1.69580111
31MP0009672_abnormal_birth_weight1.67432396
32MP0005646_abnormal_pituitary_gland1.58727543
33MP0004233_abnormal_muscle_weight1.58178649
34MP0003195_calcinosis1.57241688
35MP0005360_urolithiasis1.55697720
36MP0002876_abnormal_thyroid_physiology1.55013701
37MP0001919_abnormal_reproductive_system1.45894460
38MP0005394_taste/olfaction_phenotype1.39888694
39MP0005499_abnormal_olfactory_system1.39888694
40MP0008789_abnormal_olfactory_epithelium1.39423553
41MP0001286_abnormal_eye_development1.39100656
42MP0003283_abnormal_digestive_organ1.38430722
43MP0000428_abnormal_craniofacial_morphol1.34013409
44MP0005084_abnormal_gallbladder_morpholo1.21368989
45MP0001485_abnormal_pinna_reflex1.14698502
46MP0001542_abnormal_bone_strength1.14327671
47MP0003252_abnormal_bile_duct1.14167944
48MP0002092_abnormal_eye_morphology1.11375643
49MP0000631_abnormal_neuroendocrine_gland1.11262204
50MP0010155_abnormal_intestine_physiology1.07716036
51MP0010030_abnormal_orbit_morphology1.07576399
52MP0005220_abnormal_exocrine_pancreas0.99974559
53MP0003938_abnormal_ear_development0.98599377
54MP0000955_abnormal_spinal_cord0.97768462
55MP0002139_abnormal_hepatobiliary_system0.95784656
56MP0005623_abnormal_meninges_morphology0.93277405
57MP0005257_abnormal_intraocular_pressure0.93124071
58MP0001765_abnormal_ion_homeostasis0.92751326
59MP0001984_abnormal_olfaction0.88899234
60MP0005379_endocrine/exocrine_gland_phen0.88645274
61MP0004270_analgesia0.83392074
62MP0002233_abnormal_nose_morphology0.83361241
63MP0002136_abnormal_kidney_physiology0.83342253
64MP0003950_abnormal_plasma_membrane0.82514379
65MP0005195_abnormal_posterior_eye0.80933720
66MP0005389_reproductive_system_phenotype0.80209030
67MP0001756_abnormal_urination0.80100977
68MP0008875_abnormal_xenobiotic_pharmacok0.79187187
69MP0003011_delayed_dark_adaptation0.76504622
70MP0002098_abnormal_vibrissa_morphology0.75271158
71MP0002282_abnormal_trachea_morphology0.75246591
72MP0003115_abnormal_respiratory_system0.74969629
73MP0002234_abnormal_pharynx_morphology0.74492903
74MP0008058_abnormal_DNA_repair0.73488433
75MP0003172_abnormal_lysosome_physiology0.71667379
76MP0000230_abnormal_systemic_arterial0.69980237
77MP0002249_abnormal_larynx_morphology0.69124280
78MP0005197_abnormal_uvea_morphology0.69025310
79MP0004742_abnormal_vestibular_system0.68443445
80MP0001849_ear_inflammation0.68365518
81MP0003943_abnormal_hepatobiliary_system0.66615858
82MP0005551_abnormal_eye_electrophysiolog0.66468942
83MP0001663_abnormal_digestive_system0.66121187
84MP0005647_abnormal_sex_gland0.65797469
85MP0005193_abnormal_anterior_eye0.64297906
86MP0003303_peritoneal_inflammation0.62557829
87MP0009046_muscle_twitch0.62307145
88MP0003385_abnormal_body_wall0.62064979
89MP0000462_abnormal_digestive_system0.60692534
90MP0000163_abnormal_cartilage_morphology0.60620808
91MP0003329_amyloid_beta_deposits0.60049990
92MP0004808_abnormal_hematopoietic_stem0.59808199
93MP0000750_abnormal_muscle_regeneration0.59598623
94MP0000569_abnormal_digit_pigmentation0.59206276
95MP0002896_abnormal_bone_mineralization0.58896236
96MP0003300_gastrointestinal_ulcer0.58512480
97MP0008995_early_reproductive_senescence0.55541795
98MP0010329_abnormal_lipoprotein_level0.55093750
99MP0001873_stomach_inflammation0.55068513
100MP0003880_abnormal_central_pattern0.54956348
101MP0002177_abnormal_outer_ear0.54888237
102MP0001502_abnormal_circadian_rhythm0.54336283
103MP0001324_abnormal_eye_pigmentation0.53785046
104MP0002115_abnormal_skeleton_extremities0.53734450
105MP0001293_anophthalmia0.53664207
106MP0005423_abnormal_somatic_nervous0.53220315
107MP0005377_hearing/vestibular/ear_phenot0.52832113
108MP0003878_abnormal_ear_physiology0.52832113
109MP0001851_eye_inflammation0.52802773
110MP0005666_abnormal_adipose_tissue0.52643855
111MP0002132_abnormal_respiratory_system0.52367770
112MP0005595_abnormal_vascular_smooth0.51839889
113MP0003183_abnormal_peptide_metabolism0.51373444
114MP0001905_abnormal_dopamine_level0.51149236
115MP0002163_abnormal_gland_morphology0.50813303
116MP0004019_abnormal_vitamin_homeostasis0.49899468
117MP0003638_abnormal_response/metabolism_0.49828540
118MP0000920_abnormal_myelination0.49315715
119MP0003045_fibrosis0.47532727
120MP0003942_abnormal_urinary_system0.47295547
121MP0010386_abnormal_urinary_bladder0.47265142
122MP0002090_abnormal_vision0.47251595
123MP0005253_abnormal_eye_physiology0.47133682
124MP0004036_abnormal_muscle_relaxation0.46884016
125MP0002736_abnormal_nociception_after0.46860676
126MP0002971_abnormal_brown_adipose0.46840185
127MP0002138_abnormal_hepatobiliary_system0.45932277
128MP0005636_abnormal_mineral_homeostasis0.45878372
129MP0000778_abnormal_nervous_system0.45243994
130MP0001666_abnormal_nutrient_absorption0.44808015
131MP0001529_abnormal_vocalization0.44321267
132MP0004043_abnormal_pH_regulation0.43091428
133MP0009643_abnormal_urine_homeostasis0.42944234
134MP0004133_heterotaxia0.42650652
135MP0001764_abnormal_homeostasis0.42380504
136MP0002752_abnormal_somatic_nervous0.42109144
137MP0000383_abnormal_hair_follicle0.41390804
138MP0002928_abnormal_bile_duct0.40848739
139MP0003699_abnormal_female_reproductive0.39424111
140MP0002734_abnormal_mechanical_nocicepti0.38909781
141MP0005085_abnormal_gallbladder_physiolo0.38471211
142MP0005397_hematopoietic_system_phenotyp0.37561640
143MP0001545_abnormal_hematopoietic_system0.37561640
144MP0009745_abnormal_behavioral_response0.37551157
145MP0003879_abnormal_hair_cell0.37455560
146MP0002272_abnormal_nervous_system0.35096830
147MP0000749_muscle_degeneration0.34634578
148MP0005391_vision/eye_phenotype0.34184495
149MP0002269_muscular_atrophy0.32455541
150MP0000604_amyloidosis0.32388130
151MP0006036_abnormal_mitochondrial_physio0.32077997
152MP0000534_abnormal_ureter_morphology0.31156688
153MP0003633_abnormal_nervous_system0.30862793
154MP0009115_abnormal_fat_cell0.30839549
155MP0002118_abnormal_lipid_homeostasis0.30711368
156MP0004811_abnormal_neuron_physiology0.29228770
157MP0009278_abnormal_bone_marrow0.28685479
158MP0010307_abnormal_tumor_latency0.27032627
159MP0002152_abnormal_brain_morphology0.26695385
160MP0000751_myopathy0.26534891
161MP0001440_abnormal_grooming_behavior0.26407564
162MP0001486_abnormal_startle_reflex0.26259339
163MP0002063_abnormal_learning/memory/cond0.25646492
164MP0003861_abnormal_nervous_system0.24972018
165MP0001963_abnormal_hearing_physiology0.24472739
166MP0002796_impaired_skin_barrier0.24272247
167MP0001968_abnormal_touch/_nociception0.24234073
168MP0003631_nervous_system_phenotype0.24033784
169MP0000013_abnormal_adipose_tissue0.22951184
170MP0002572_abnormal_emotion/affect_behav0.22519481
171MP0004145_abnormal_muscle_electrophysio0.21627594
172MP0003948_abnormal_gas_homeostasis0.21505834
173MP0003866_abnormal_defecation0.21020431
174MP0002873_normal_phenotype0.20942513
175MP0002169_no_abnormal_phenotype0.20934222
176MP0001727_abnormal_embryo_implantation0.20673382

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.29708241
2Abnormal respiratory epithelium morphology (HP:0012253)8.95173154
3Abnormal respiratory motile cilium morphology (HP:0005938)8.95173154
4Rhinitis (HP:0012384)7.73841870
5Abnormal ciliary motility (HP:0012262)7.27368334
6Chronic bronchitis (HP:0004469)7.18112508
7Infertility (HP:0000789)6.76249122
8Nasal polyposis (HP:0100582)6.31907937
9Delayed CNS myelination (HP:0002188)6.28098938
10Redundant skin (HP:0001582)5.26124769
11Abnormality of the nasal mucosa (HP:0000433)5.16145820
12Hypokinesia (HP:0002375)5.08385126
13Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.93059221
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.80275652
1511 pairs of ribs (HP:0000878)4.65780336
16Bronchiectasis (HP:0002110)4.55250443
17Increased serum pyruvate (HP:0003542)4.50201814
18Abnormal vertebral ossification (HP:0100569)4.40922315
19Bronchitis (HP:0012387)4.37864742
20Congenital stationary night blindness (HP:0007642)4.34795458
21Nephronophthisis (HP:0000090)4.25797872
22Aplastic anemia (HP:0001915)4.24192820
23Hypoplastic ischia (HP:0003175)4.16220196
24Abnormality of cells of the erythroid lineage (HP:0012130)4.06718631
25Epileptic encephalopathy (HP:0200134)4.03643190
26Male infertility (HP:0003251)3.93122543
27Delayed myelination (HP:0012448)3.89922517
28Ependymoma (HP:0002888)3.89524332
29Abnormality of fatty-acid metabolism (HP:0004359)3.88261751
30Diminished movement (HP:0002374)3.75522932
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.75340763
32Molar tooth sign on MRI (HP:0002419)3.58990678
33Abnormality of midbrain morphology (HP:0002418)3.58990678
34Abnormality of glycolysis (HP:0004366)3.56798671
35Abnormality of the ischium (HP:0003174)3.46491162
36Enlarged penis (HP:0000040)3.36187461
37Arthropathy (HP:0003040)3.21014899
38Vertebral clefting (HP:0008428)3.20370260
39Abnormality of the renal medulla (HP:0100957)3.18111227
40Renal cortical cysts (HP:0000803)3.13333182
41Recurrent otitis media (HP:0000403)3.11375722
42Recurrent sinusitis (HP:0011108)3.07075245
43Abnormal spermatogenesis (HP:0008669)3.05050201
44Macrocytic anemia (HP:0001972)3.04734639
45Widely patent fontanelles and sutures (HP:0004492)3.00783154
46Generalized aminoaciduria (HP:0002909)2.99994270
47Pathologic fracture (HP:0002756)2.87821400
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.84818709
49Cholecystitis (HP:0001082)2.71831234
50Abnormal gallbladder physiology (HP:0012438)2.71831234
51Stenosis of the external auditory canal (HP:0000402)2.69323145
52Testicular atrophy (HP:0000029)2.68616844
53Anterior segment dysgenesis (HP:0007700)2.68485688
54Poor eye contact (HP:0000817)2.66957642
55Abnormal foot bone ossification (HP:0010675)2.64221979
56Abnormal hand bone ossification (HP:0010660)2.61315750
57Skin nodule (HP:0200036)2.57701706
58Multiple enchondromatosis (HP:0005701)2.55050806
59Tubulointerstitial nephritis (HP:0001970)2.54480235
60Tubular atrophy (HP:0000092)2.53860070
61Agitation (HP:0000713)2.53115536
62Recurrent bronchitis (HP:0002837)2.51032899
63Tubulointerstitial abnormality (HP:0001969)2.49706356
64Barrel-shaped chest (HP:0001552)2.47335579
65Missing ribs (HP:0000921)2.45035801
66Epidermoid cyst (HP:0200040)2.43890002
67Increased serum ferritin (HP:0003281)2.43086311
68Menstrual irregularities (HP:0000858)2.40865170
69Hypoplasia of the radius (HP:0002984)2.40625688
70Protuberant abdomen (HP:0001538)2.38912316
71Impulsivity (HP:0100710)2.37188890
72Hyperthyroidism (HP:0000836)2.36797108
73Abnormal social behavior (HP:0012433)2.36693046
74Impaired social interactions (HP:0000735)2.36693046
75Astrocytoma (HP:0009592)2.35729613
76Abnormality of the astrocytes (HP:0100707)2.35729613
77Gonadotropin excess (HP:0000837)2.35230525
78Broad face (HP:0000283)2.29796735
79Stereotypic behavior (HP:0000733)2.29653878
80Hepatic necrosis (HP:0002605)2.27724864
81Adrenal hypoplasia (HP:0000835)2.26015141
82Tubulointerstitial fibrosis (HP:0005576)2.25757023
83Medial flaring of the eyebrow (HP:0010747)2.23976924
84Striae distensae (HP:0001065)2.19963921
85Stillbirth (HP:0003826)2.19854694
86Flared iliac wings (HP:0002869)2.19726234
87Macroorchidism (HP:0000053)2.19267940
88Dialeptic seizures (HP:0011146)2.17506305
89Pallor (HP:0000980)2.15891865
90Congenital malformation of the right heart (HP:0011723)2.14154645
91Double outlet right ventricle (HP:0001719)2.14154645
92Abnormality of the 4th metacarpal (HP:0010012)2.14014104
93Postaxial foot polydactyly (HP:0001830)2.11053839
94Azoospermia (HP:0000027)2.10527394
95Rhabdomyolysis (HP:0003201)2.07410878
96Thickened calvaria (HP:0002684)2.06683972
97Xanthomatosis (HP:0000991)2.04768257
98Absence seizures (HP:0002121)2.03812976
99Protruding tongue (HP:0010808)2.00763932
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8411091
101Absent/shortened dynein arms (HP:0200106)12.5689065
102Dynein arm defect of respiratory motile cilia (HP:0012255)12.5689065
103Hypsarrhythmia (HP:0002521)1.99517635
104Anophthalmia (HP:0000528)1.99378171
105Flat face (HP:0012368)1.98639566
106Fibular hypoplasia (HP:0003038)1.98347479
107Amyotrophic lateral sclerosis (HP:0007354)1.97212601
108Abnormality of the renal cortex (HP:0011035)1.96514897
109Epiphyseal stippling (HP:0010655)1.96426577
110Osteomalacia (HP:0002749)1.93054583
111Neoplasm of the heart (HP:0100544)1.92990148
112Dyschromatopsia (HP:0007641)1.92753083
113Abnormality of magnesium homeostasis (HP:0004921)1.92611099
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92409267
115Stage 5 chronic kidney disease (HP:0003774)1.92203721
116Neurofibrillary tangles (HP:0002185)1.91389495
117Reticulocytopenia (HP:0001896)1.89602914
118EEG with generalized epileptiform discharges (HP:0011198)1.88331413
119Loss of speech (HP:0002371)1.87515588
120Abnormal hemoglobin (HP:0011902)1.87438914
121Polydipsia (HP:0001959)1.87149463
122Abnormal drinking behavior (HP:0030082)1.87149463
123Atonic seizures (HP:0010819)1.87091394
124Congenital hepatic fibrosis (HP:0002612)1.86278444
125Lymphangioma (HP:0100764)1.84113126
126Progressive muscle weakness (HP:0003323)1.83900354
127Fragile nails (HP:0001808)1.83842799
128Abnormality of iron homeostasis (HP:0011031)1.82758183
129Spastic tetraparesis (HP:0001285)1.82430708
130Choroideremia (HP:0001139)1.81449841
131Abnormal number of erythroid precursors (HP:0012131)1.81383850
132Chronic hepatic failure (HP:0100626)1.81078624
133Status epilepticus (HP:0002133)1.81022891
134Akinesia (HP:0002304)1.80888134
135Increased serum lactate (HP:0002151)1.79666771
136Hepatocellular necrosis (HP:0001404)1.79611418
137Macroglossia (HP:0000158)1.79483386
138Palpebral edema (HP:0100540)1.78697746
139Abnormality of the lower motor neuron (HP:0002366)1.77650041
140Epileptiform EEG discharges (HP:0011182)1.77099013
141Bell-shaped thorax (HP:0001591)1.75050305
142Abnormality of renal excretion (HP:0011036)1.67623942
143Malnutrition (HP:0004395)1.66634536
144Renal dysplasia (HP:0000110)1.61524481
145Decreased central vision (HP:0007663)1.59412158
146Facial cleft (HP:0002006)1.59353956
147Exercise-induced myalgia (HP:0003738)1.58205035
148Microglossia (HP:0000171)1.52879114
149Easy fatigability (HP:0003388)1.51198476
150Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.50979464
151Absent epiphyses (HP:0010577)1.50979464
152Abnormality of permanent molar morphology (HP:0011071)1.50112855
153Abnormality of the dental root (HP:0006486)1.50112855
154Taurodontia (HP:0000679)1.50112855
155Disinhibition (HP:0000734)1.49683191
156Abnormality of dentin (HP:0010299)1.49632735
157Abnormality of the anterior horn cell (HP:0006802)1.48416550
158Degeneration of anterior horn cells (HP:0002398)1.48416550
159Cerebral inclusion bodies (HP:0100314)1.47511804
160Short ribs (HP:0000773)1.47230653
161Postaxial hand polydactyly (HP:0001162)1.46511156
162Chronic sinusitis (HP:0011109)1.44783834
163Oculomotor apraxia (HP:0000657)1.44441142
164Abnormal urine output (HP:0012590)1.43576732
165Hypercholesterolemia (HP:0003124)1.43550100
166Heterotopia (HP:0002282)1.43331045
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.42041514
168Abnormality of the dental pulp (HP:0006479)1.38560860
169Hemiparesis (HP:0001269)1.37674828
170Impaired proprioception (HP:0010831)1.37674373
171Bundle branch block (HP:0011710)1.37642397
172Aplasia/Hypoplasia of the lens (HP:0008063)1.37158625
173Hemorrhage of the eye (HP:0011885)1.36837466
174Abnormality of molar (HP:0011077)1.36188805
175Abnormality of molar morphology (HP:0011070)1.36188805
176Neuronal loss in central nervous system (HP:0002529)1.34489306
177Hyperkalemia (HP:0002153)1.33716878
178Fatigable weakness (HP:0003473)1.32790038
179Abnormality of the neuromuscular junction (HP:0003398)1.32790038
180Aplasia/Hypoplasia of the tongue (HP:0010295)1.31299720
181Nephropathy (HP:0000112)1.30973037
182Short femoral neck (HP:0100864)1.30344012
183Cystic liver disease (HP:0006706)1.29488853
184J-shaped sella turcica (HP:0002680)1.26842548
185Personality changes (HP:0000751)1.26075758
186Short thorax (HP:0010306)1.25777007
187Deformed sella turcica (HP:0002681)1.25063617
188Abnormality of the sella turcica (HP:0002679)1.24425558
189Myoglobinuria (HP:0002913)1.24234858
190Pachygyria (HP:0001302)1.23991296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK17.31066575
2PDK37.06935169
3PDK47.06935169
4ICK5.74341137
5PRKD34.61181458
6PDK24.56964479
7SIK33.82565831
8IRAK42.77003017
9PTK2B2.59302771
10NME12.52368809
11SIK12.42798647
12SIK22.31203505
13CDK82.23146695
14STK392.10953044
15DYRK22.06518667
16MAPKAPK32.00987712
17NEK22.00099024
18TRIM2811.1391063
19STK381.99991110
20WNK41.97393265
21MAP3K21.81538324
22PIK3CA1.69304198
23PNCK1.53524635
24TRPM71.52565475
25DYRK1B1.52268798
26NUAK11.49348103
27MAPK121.43686335
28TYRO31.42013119
29PDK11.41758943
30STK161.38450645
31MAPK151.28200358
32IKBKE1.24048809
33TRIB31.19688105
34RPS6KB21.19578160
35MELK1.18152700
36EEF2K1.16558804
37CDC71.15514658
38EPHA41.11939935
39MUSK1.11865526
40CDK71.09760569
41MARK31.08741956
42PDPK11.06059547
43LIMK11.05283017
44EPHB21.02644960
45WNK10.93658621
46TESK20.86193461
47CCNB10.83145402
48CAMK10.81490010
49BMPR1B0.76427232
50FES0.75655442
51IRAK10.74853799
52RIPK40.74842304
53TIE10.73837490
54EPHB10.70037928
55MAPK130.67075826
56TTK0.57806607
57STK30.57153625
58ADRBK10.54825559
59RPS6KA40.54342644
60MAP3K70.54253022
61NTRK20.52635394
62MAPKAPK50.48812321
63PASK0.47672531
64PRKCI0.47422701
65PINK10.46611785
66CAMK1D0.46365999
67LMTK20.45595529
68CDK90.42424839
69CHEK20.42177234
70MAP3K50.41670191
71RPS6KA50.41369946
72ABL20.39699850
73MKNK20.39401903
74PLK20.38712892
75MAP2K60.38569087
76MAP3K100.38453363
77MAPK110.38139478
78DYRK30.37871533
79TGFBR10.36991097
80PAK20.36661712
81ARAF0.36207586
82ADRBK20.34273514
83IRAK20.34235040
84PRKCG0.33725064
85MAP2K30.33319466
86RPS6KB10.32615462
87PRKCQ0.32547390
88CAMK40.31317338
89NEK60.31150651
90RPS6KA60.31138481
91PAK10.30719071
92BRD40.29563278
93MTOR0.28954234
94CAMK1G0.26758480
95CSK0.26472629
96MARK20.25877437
97AURKB0.24709258
98MST1R0.24672546
99RPS6KA20.24282509
100INSRR0.24223286
101MAP2K20.23918997
102CDC42BPA0.23724951
103LRRK20.23014348
104MAP3K80.22444422
105CAMKK10.22292331
106CDK40.21481508
107CLK10.19550009
108RET0.19291100
109PTK60.19278791
110PRKG20.19142468
111ATM0.18665785
112PRKAA10.18390601
113MAP4K20.17198207
114PRKCZ0.17163139
115PRKD20.17035723
116CHEK10.16542090
117KSR10.16266802
118DDR20.15727421
119PIK3CG0.15548382
120MYLK0.15438732
121WEE10.14715283
122CDK20.13884778
123ERBB20.13690648
124AKT20.13484849
125PAK40.13419843
126FGFR10.13288173
127CSF1R0.12837052
128CDK10.12118847
129ATR0.12001760
130GRK10.11203127
131BRAF0.10335211
132AKT10.09977008
133CDK140.09858574
134FRK0.09776831
135BRSK10.09710570
136YES10.09387460
137MAPK140.09206728
138GSK3A0.08919992
139CSNK2A10.07069028
140MAP3K90.07026262
141PRKG10.06601589
142PKN10.06401563
143GSK3B0.06369966
144RPS6KA10.05820441
145PTK20.05707409
146CDK150.05259363
147PRKAA20.05042606
148PRKACG0.04658546
149SRC0.04484414
150MAPK80.04365727
151MARK10.04260024
152PRKCH0.04226696
153CAMK2A0.03984368
154TBK10.03266825
155STK40.03090428
156PIM10.03040240
157PRKCD0.02957098
158CDK120.02568462
159CDK11A0.02562069
160PRKCB0.02043004
161CDK180.01923154
162TAOK30.01902342
163PRKCA0.01374787
164EGFR0.01171132
165RPS6KA30.01006420
166STK10-0.0045351
167BLK-0.0026843

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.46732960
2Fatty acid biosynthesis_Homo sapiens_hsa000613.94340526
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.87804722
4Vitamin B6 metabolism_Homo sapiens_hsa007503.86015554
5Protein export_Homo sapiens_hsa030603.84226646
6Ribosome_Homo sapiens_hsa030103.72685909
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.65104032
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.38140158
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.25295973
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.15912987
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.09808236
12Pyruvate metabolism_Homo sapiens_hsa006203.08554551
13Folate biosynthesis_Homo sapiens_hsa007903.06432894
14Linoleic acid metabolism_Homo sapiens_hsa005913.01717844
15Fat digestion and absorption_Homo sapiens_hsa049753.01588767
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.89055949
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71695546
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.60426803
19Propanoate metabolism_Homo sapiens_hsa006402.44249267
20Arginine biosynthesis_Homo sapiens_hsa002202.41040626
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36036648
22Glucagon signaling pathway_Homo sapiens_hsa049222.28570452
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28268096
24Glycerolipid metabolism_Homo sapiens_hsa005612.18508275
25Mineral absorption_Homo sapiens_hsa049782.09112174
26PPAR signaling pathway_Homo sapiens_hsa033201.93668435
27Ether lipid metabolism_Homo sapiens_hsa005651.85537846
28Amphetamine addiction_Homo sapiens_hsa050311.81393226
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.78754176
30Butanoate metabolism_Homo sapiens_hsa006501.74160707
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.71873976
32Selenocompound metabolism_Homo sapiens_hsa004501.70358976
33Homologous recombination_Homo sapiens_hsa034401.66305564
34Steroid biosynthesis_Homo sapiens_hsa001001.63611590
35Retinol metabolism_Homo sapiens_hsa008301.58398671
36RNA polymerase_Homo sapiens_hsa030201.56567423
37Mismatch repair_Homo sapiens_hsa034301.51961463
38Basal transcription factors_Homo sapiens_hsa030221.49894074
39Fructose and mannose metabolism_Homo sapiens_hsa000511.48856391
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48741718
41Cardiac muscle contraction_Homo sapiens_hsa042601.47033974
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45846669
43Pentose phosphate pathway_Homo sapiens_hsa000301.38784624
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37987000
45Glutathione metabolism_Homo sapiens_hsa004801.31550045
46Parkinsons disease_Homo sapiens_hsa050121.30643285
47Renin secretion_Homo sapiens_hsa049241.28555960
48Oxidative phosphorylation_Homo sapiens_hsa001901.25034554
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23646358
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21153578
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20497402
52Fatty acid metabolism_Homo sapiens_hsa012121.17683859
53Renin-angiotensin system_Homo sapiens_hsa046141.17355750
54Fatty acid degradation_Homo sapiens_hsa000711.16059825
55Huntingtons disease_Homo sapiens_hsa050161.11681299
56Peroxisome_Homo sapiens_hsa041461.11643930
57Phototransduction_Homo sapiens_hsa047441.11637932
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08590739
59Carbon metabolism_Homo sapiens_hsa012001.07971843
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06788591
61Base excision repair_Homo sapiens_hsa034101.05609490
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.05221567
63Oocyte meiosis_Homo sapiens_hsa041141.05009445
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99699162
65ABC transporters_Homo sapiens_hsa020100.98293030
66Bile secretion_Homo sapiens_hsa049760.96075614
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94479685
68Long-term potentiation_Homo sapiens_hsa047200.92818510
69Dorso-ventral axis formation_Homo sapiens_hsa043200.92045925
70Olfactory transduction_Homo sapiens_hsa047400.91918327
71Protein digestion and absorption_Homo sapiens_hsa049740.91911770
72Arachidonic acid metabolism_Homo sapiens_hsa005900.90937153
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87268146
74Insulin secretion_Homo sapiens_hsa049110.86248135
75Prion diseases_Homo sapiens_hsa050200.83455446
76Hippo signaling pathway_Homo sapiens_hsa043900.82888523
77Circadian entrainment_Homo sapiens_hsa047130.82584871
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.82035354
79Sphingolipid metabolism_Homo sapiens_hsa006000.78256299
80Collecting duct acid secretion_Homo sapiens_hsa049660.76168505
81Thyroid hormone synthesis_Homo sapiens_hsa049180.75201562
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74968450
83Bladder cancer_Homo sapiens_hsa052190.74863424
84Chemical carcinogenesis_Homo sapiens_hsa052040.74036791
85Systemic lupus erythematosus_Homo sapiens_hsa053220.73050765
86Hedgehog signaling pathway_Homo sapiens_hsa043400.71628315
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.71120360
88mRNA surveillance pathway_Homo sapiens_hsa030150.70840085
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70203017
90Purine metabolism_Homo sapiens_hsa002300.69410702
91Pyrimidine metabolism_Homo sapiens_hsa002400.68416707
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.67969434
93Salivary secretion_Homo sapiens_hsa049700.66225353
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65892338
95RNA degradation_Homo sapiens_hsa030180.65521178
96Caffeine metabolism_Homo sapiens_hsa002320.64600243
97Tryptophan metabolism_Homo sapiens_hsa003800.63277750
98Ovarian steroidogenesis_Homo sapiens_hsa049130.62907259
99Galactose metabolism_Homo sapiens_hsa000520.61149772
100Pancreatic secretion_Homo sapiens_hsa049720.60966770
101Estrogen signaling pathway_Homo sapiens_hsa049150.60920584
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60702074
103Alzheimers disease_Homo sapiens_hsa050100.57488874
104TGF-beta signaling pathway_Homo sapiens_hsa043500.57312500
105Vitamin digestion and absorption_Homo sapiens_hsa049770.56516771
106Dilated cardiomyopathy_Homo sapiens_hsa054140.55720762
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54569438
108Antigen processing and presentation_Homo sapiens_hsa046120.53775427
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53682190
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52861127
111Gastric acid secretion_Homo sapiens_hsa049710.51558388
112Calcium signaling pathway_Homo sapiens_hsa040200.50745514
113Pancreatic cancer_Homo sapiens_hsa052120.49850922
114Alcoholism_Homo sapiens_hsa050340.49049254
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.48534922
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48428472
117Cocaine addiction_Homo sapiens_hsa050300.48291938
118Glutamatergic synapse_Homo sapiens_hsa047240.47787388
119One carbon pool by folate_Homo sapiens_hsa006700.47301635
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46086599
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.45869993
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45599762
123Starch and sucrose metabolism_Homo sapiens_hsa005000.43035203
124Fanconi anemia pathway_Homo sapiens_hsa034600.42532775
125Vibrio cholerae infection_Homo sapiens_hsa051100.42528973
126Synaptic vesicle cycle_Homo sapiens_hsa047210.40757598
127Salmonella infection_Homo sapiens_hsa051320.39805516
128HIF-1 signaling pathway_Homo sapiens_hsa040660.39400652
129AMPK signaling pathway_Homo sapiens_hsa041520.38730192
130Biosynthesis of amino acids_Homo sapiens_hsa012300.35920612
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35763564
132Metabolic pathways_Homo sapiens_hsa011000.35690371
133cAMP signaling pathway_Homo sapiens_hsa040240.35262910
134Endocytosis_Homo sapiens_hsa041440.35212784
135Morphine addiction_Homo sapiens_hsa050320.33355983
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.33254663
137Sulfur metabolism_Homo sapiens_hsa009200.32497368
138Basal cell carcinoma_Homo sapiens_hsa052170.32453509
139VEGF signaling pathway_Homo sapiens_hsa043700.30986685
140Taste transduction_Homo sapiens_hsa047420.30938897
141Complement and coagulation cascades_Homo sapiens_hsa046100.30811055
142Other glycan degradation_Homo sapiens_hsa005110.30769626
143Tyrosine metabolism_Homo sapiens_hsa003500.29578788
144N-Glycan biosynthesis_Homo sapiens_hsa005100.28986547
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28593616
146Arginine and proline metabolism_Homo sapiens_hsa003300.28203183
147Gap junction_Homo sapiens_hsa045400.27390146
148Chemokine signaling pathway_Homo sapiens_hsa040620.26834706
149Nucleotide excision repair_Homo sapiens_hsa034200.26148026
150Legionellosis_Homo sapiens_hsa051340.26034778
151Inositol phosphate metabolism_Homo sapiens_hsa005620.25810480
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25160237
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24830837
154Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24242844
155African trypanosomiasis_Homo sapiens_hsa051430.24207653
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21792362
157Axon guidance_Homo sapiens_hsa043600.21025043
158Long-term depression_Homo sapiens_hsa047300.20936716
159Type II diabetes mellitus_Homo sapiens_hsa049300.20077302
160Amoebiasis_Homo sapiens_hsa051460.19843478
161Dopaminergic synapse_Homo sapiens_hsa047280.17644784
162Histidine metabolism_Homo sapiens_hsa003400.16789690
163Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15136316

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