TMEM8A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)3.80506487
2negative regulation of erythrocyte differentiation (GO:0045647)3.69724264
3protein localization to endosome (GO:0036010)3.64350113
4regulation of extracellular matrix disassembly (GO:0010715)3.56268440
5positive regulation of Cdc42 GTPase activity (GO:0043089)3.55183618
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.50568589
7positive regulation by symbiont of host defense response (GO:0052509)3.45129465
8modulation by symbiont of host defense response (GO:0052031)3.45129465
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.45129465
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.45129465
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.45129465
12modulation by symbiont of host immune response (GO:0052553)3.45129465
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34032226
14basement membrane organization (GO:0071711)3.25779108
15barbed-end actin filament capping (GO:0051016)3.18485074
16regulation of early endosome to late endosome transport (GO:2000641)3.17818058
17response to peptidoglycan (GO:0032494)3.12530980
18antigen processing and presentation of endogenous antigen (GO:0019883)3.10647982
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10601130
20COPI coating of Golgi vesicle (GO:0048205)3.03157795
21Golgi transport vesicle coating (GO:0048200)3.03157795
22apoptotic process involved in morphogenesis (GO:0060561)3.00369846
23response to laminar fluid shear stress (GO:0034616)2.99698635
24negative regulation of cell killing (GO:0031342)2.97144956
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97144956
26stress fiber assembly (GO:0043149)2.90444411
27negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.88504297
28positive regulation of receptor recycling (GO:0001921)2.87551724
29semaphorin-plexin signaling pathway (GO:0071526)2.80618535
30positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76899246
31pinocytosis (GO:0006907)2.73642841
32macrophage activation involved in immune response (GO:0002281)2.65613794
33protein retention in ER lumen (GO:0006621)2.65378033
34adherens junction assembly (GO:0034333)2.64209825
35modulation by symbiont of host cellular process (GO:0044068)2.61000570
36detection of other organism (GO:0098543)2.57353515
37peptide catabolic process (GO:0043171)2.56981218
38epithelial cell-cell adhesion (GO:0090136)2.56581008
39maternal placenta development (GO:0001893)2.56569648
40glucose 6-phosphate metabolic process (GO:0051156)2.56297739
41lipopolysaccharide-mediated signaling pathway (GO:0031663)2.55160525
42positive regulation of blood vessel endothelial cell migration (GO:0043536)2.53643447
43detection of bacterium (GO:0016045)2.51719009
44glycosphingolipid catabolic process (GO:0046479)2.51143950
45regulation of cholesterol homeostasis (GO:2000188)2.50453982
46antigen processing and presentation via MHC class Ib (GO:0002475)2.49860612
47amyloid precursor protein catabolic process (GO:0042987)2.49446689
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.49339267
49regulation of T-helper 2 cell differentiation (GO:0045628)2.48256778
50NIK/NF-kappaB signaling (GO:0038061)2.47080427
51cell-substrate adherens junction assembly (GO:0007045)2.46458426
52focal adhesion assembly (GO:0048041)2.46458426
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43936258
54regulation of leukocyte degranulation (GO:0043300)2.42777288
55negative regulation of fatty acid transport (GO:2000192)2.42752499
56regulation of extracellular matrix organization (GO:1903053)2.41537712
57positive regulation of histone deacetylation (GO:0031065)2.41204424
58hyaluronan catabolic process (GO:0030214)2.40569986
59pentose-phosphate shunt (GO:0006098)2.39458330
60modulation by virus of host process (GO:0019054)2.38540831
61negative regulation of viral release from host cell (GO:1902187)2.38228757
62detection of external biotic stimulus (GO:0098581)2.38183678
63detection of molecule of bacterial origin (GO:0032490)2.38074935
64vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.37251444
65epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37236800
66negative regulation of cell size (GO:0045792)2.36713021
67cell-cell junction maintenance (GO:0045217)2.36171160
68activation of Rac GTPase activity (GO:0032863)2.34811425
69retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.33746741
70skin morphogenesis (GO:0043589)2.33426094
71cell-substrate junction assembly (GO:0007044)2.31972093
72regulation of apoptotic process involved in morphogenesis (GO:1902337)2.31784702
73neutrophil activation involved in immune response (GO:0002283)2.30687291
74embryonic process involved in female pregnancy (GO:0060136)2.30341650
75adhesion of symbiont to host (GO:0044406)2.30125110
76regulation of interferon-beta biosynthetic process (GO:0045357)2.28962327
77endothelial cell chemotaxis (GO:0035767)2.28847612
78apoptotic cell clearance (GO:0043277)2.28133700
79glycolipid catabolic process (GO:0019377)2.26893584
80amino sugar catabolic process (GO:0046348)2.25986716
81positive regulation of extracellular matrix organization (GO:1903055)2.24140051
82regulation of defense response to virus by virus (GO:0050690)2.23595871
83positive regulation of protein dephosphorylation (GO:0035307)2.21860939
84regulation of ARF GTPase activity (GO:0032312)2.21244305
85regulation of superoxide anion generation (GO:0032928)2.19491642
86signal complex assembly (GO:0007172)2.18872747
87response to muramyl dipeptide (GO:0032495)2.18306441
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.17750143
89regulation of myeloid leukocyte mediated immunity (GO:0002886)2.17384208
90glucose catabolic process (GO:0006007)2.15797866
91regulation of lipid kinase activity (GO:0043550)2.13782025
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.13255497
93leukocyte aggregation (GO:0070486)2.11951674
94endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.11918500
95negative regulation of adherens junction organization (GO:1903392)2.11666371
96negative regulation of focal adhesion assembly (GO:0051895)2.11666371
97negative regulation of cell junction assembly (GO:1901889)2.11666371
98positive regulation of lipid kinase activity (GO:0090218)2.10980741
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.09625594
100response to host defenses (GO:0052200)2.09625594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.07015052
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.91817606
3LXR_22292898_ChIP-Seq_THP-1_Human2.87154726
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.79279197
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.73808078
6* ELK3_25401928_ChIP-Seq_HUVEC_Human2.73420154
7VDR_21846776_ChIP-Seq_THP-1_Human2.60805623
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.58602546
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.55297319
10* RACK7_27058665_Chip-Seq_MCF-7_Human2.35749852
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28896730
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23823567
13MYC_22102868_ChIP-Seq_BL_Human2.23296495
14TCF7_22412390_ChIP-Seq_EML_Mouse2.11492782
15KDM2B_26808549_Chip-Seq_DND41_Human2.03989951
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.93185924
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91821393
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91432542
19VDR_24763502_ChIP-Seq_THP-1_Human1.79998803
20* KDM2B_26808549_Chip-Seq_K562_Human1.76854800
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67808143
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64401518
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64401113
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62124684
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60194632
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.56518911
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54920578
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53404515
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52647959
30ZNF263_19887448_ChIP-Seq_K562_Human1.52582041
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49906574
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48104985
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47874066
34MAF_26560356_Chip-Seq_TH1_Human1.47600643
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47024926
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45893036
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45676670
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44754851
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43884945
40SA1_27219007_Chip-Seq_ERYTHROID_Human1.43080718
41P68_20966046_ChIP-Seq_HELA_Human1.42503938
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.42478089
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42268420
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39718480
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.38232618
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37646532
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.37630305
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35259248
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35122514
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34952447
51CLOCK_20551151_ChIP-Seq_293T_Human1.34662536
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.33725436
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33412269
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32398567
55SMC4_20622854_ChIP-Seq_HELA_Human1.31556968
56* UTX_26944678_Chip-Seq_JUKART_Human1.31148921
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26240921
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.25609311
59MAF_26560356_Chip-Seq_TH2_Human1.24812679
60NCOR1_26117541_ChIP-Seq_K562_Human1.24767731
61SPI1_23127762_ChIP-Seq_K562_Human1.23043294
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23039982
63ATF3_27146783_Chip-Seq_COLON_Human1.20364326
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.20079173
65BCOR_27268052_Chip-Seq_Bcells_Human1.20077760
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19829154
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.19631114
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19024415
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18527583
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18475629
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17907882
72* CREB1_26743006_Chip-Seq_LNCaP_Human1.16859287
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16840751
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14833160
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.14670234
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.13709013
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12245689
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11988104
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10915019
80TP53_22127205_ChIP-Seq_IMR90_Human1.10521664
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.09555192
82* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09011942
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.08942721
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08410527
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06085263
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05570826
87BCL6_27268052_Chip-Seq_Bcells_Human1.05536698
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04932996
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.04364323
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03822498
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03431144
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.03370081
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02464932
94GATA1_19941826_ChIP-Seq_K562_Human1.02350882
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01574503
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01134397
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99308160
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97873321
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97869896
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97812348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.84283353
2MP0005058_abnormal_lysosome_morphology3.42536520
3MP0005451_abnormal_body_composition2.86333545
4MP0009840_abnormal_foam_cell2.84087961
5MP0003303_peritoneal_inflammation2.72203719
6MP0003436_decreased_susceptibility_to2.70347361
7MP0008438_abnormal_cutaneous_collagen2.65588913
8MP0003172_abnormal_lysosome_physiology2.59963359
9MP0003300_gastrointestinal_ulcer2.57179251
10MP0001849_ear_inflammation2.34530654
11MP0003566_abnormal_cell_adhesion2.26677270
12MP0004858_abnormal_nervous_system2.22251849
13MP0008260_abnormal_autophagy2.19892680
14MP0002254_reproductive_system_inflammat2.12565948
15MP0003191_abnormal_cellular_cholesterol2.06717955
16MP0010234_abnormal_vibrissa_follicle1.96117418
17MP0003279_aneurysm1.93257404
18MP0004510_myositis1.91662964
19MP0004272_abnormal_basement_membrane1.86206978
20MP0003724_increased_susceptibility_to1.80788390
21MP0004264_abnormal_extraembryonic_tissu1.80484497
22MP0005409_darkened_coat_color1.78777496
23MP0005257_abnormal_intraocular_pressure1.74224837
24MP0001533_abnormal_skeleton_physiology1.70220828
25MP0005076_abnormal_cell_differentiation1.68555497
26MP0000858_altered_metastatic_potential1.64374140
27MP0002419_abnormal_innate_immunity1.59638807
28MP0004947_skin_inflammation1.58228225
29MP0003091_abnormal_cell_migration1.54968087
30MP0000678_abnormal_parathyroid_gland1.51877068
31MP0002998_abnormal_bone_remodeling1.51681910
32MP0003453_abnormal_keratinocyte_physiol1.51155657
33MP0003183_abnormal_peptide_metabolism1.48502288
34MP0002877_abnormal_melanocyte_morpholog1.47279960
35MP0006082_CNS_inflammation1.45905770
36MP0005025_abnormal_response_to1.42199760
37MP0010155_abnormal_intestine_physiology1.40070384
38MP0001958_emphysema1.39651603
39MP0009278_abnormal_bone_marrow1.38773874
40MP0005464_abnormal_platelet_physiology1.36247756
41MP0000767_abnormal_smooth_muscle1.30318089
42MP0005360_urolithiasis1.28247178
43MP0000685_abnormal_immune_system1.26577074
44MP0005023_abnormal_wound_healing1.26468043
45MP0009333_abnormal_splenocyte_physiolog1.25642414
46MP0002089_abnormal_postnatal_growth/wei1.17408225
47MP0001790_abnormal_immune_system1.13691998
48MP0005387_immune_system_phenotype1.13691998
49MP0005000_abnormal_immune_tolerance1.12141197
50MP0002796_impaired_skin_barrier1.10522987
51MP0004185_abnormal_adipocyte_glucose1.10052762
52MP0003828_pulmonary_edema1.09939822
53MP0005390_skeleton_phenotype1.08737632
54MP0009785_altered_susceptibility_to1.06356023
55MP0000604_amyloidosis1.05265296
56MP0000490_abnormal_crypts_of1.04618960
57MP0003075_altered_response_to1.04587625
58MP0003329_amyloid_beta_deposits1.02729744
59MP0001873_stomach_inflammation0.97493961
60MP0008004_abnormal_stomach_pH0.97335530
61MP0005083_abnormal_biliary_tract0.96774239
62MP0009384_cardiac_valve_regurgitation0.96505225
63MP0004233_abnormal_muscle_weight0.96363501
64MP0001835_abnormal_antigen_presentation0.95715186
65MP0010368_abnormal_lymphatic_system0.95586271
66MP0002139_abnormal_hepatobiliary_system0.94170381
67MP0001819_abnormal_immune_cell0.93046636
68MP0002933_joint_inflammation0.93008862
69MP0002452_abnormal_antigen_presenting0.92998359
70MP0002723_abnormal_immune_serum0.92502420
71MP0003866_abnormal_defecation0.91963023
72MP0002420_abnormal_adaptive_immunity0.91913462
73MP0001845_abnormal_inflammatory_respons0.91145728
74MP0002148_abnormal_hypersensitivity_rea0.90736387
75MP0008469_abnormal_protein_level0.90682888
76MP0001915_intracranial_hemorrhage0.90302246
77MP0005310_abnormal_salivary_gland0.88889177
78MP0000343_altered_response_to0.86254270
79MP0003448_altered_tumor_morphology0.83165189
80MP0002405_respiratory_system_inflammati0.82585862
81MP0004381_abnormal_hair_follicle0.81868484
82MP0003795_abnormal_bone_structure0.81193838
83MP0001800_abnormal_humoral_immune0.78800134
84MP0005365_abnormal_bile_salt0.78688245
85MP0010352_gastrointestinal_tract_polyps0.78088046
86MP0001663_abnormal_digestive_system0.78078703
87MP0002060_abnormal_skin_morphology0.77860252
88MP0002896_abnormal_bone_mineralization0.77079533
89MP0002249_abnormal_larynx_morphology0.76735182
90MP0002132_abnormal_respiratory_system0.74992663
91MP0005375_adipose_tissue_phenotype0.73890436
92MP0003763_abnormal_thymus_physiology0.73132919
93MP0000249_abnormal_blood_vessel0.72875521
94MP0005501_abnormal_skin_physiology0.72315248
95MP0005666_abnormal_adipose_tissue0.71328191
96MP0005166_decreased_susceptibility_to0.70812562
97MP0006054_spinal_hemorrhage0.70553082
98MP0005381_digestive/alimentary_phenotyp0.69446573
99MP0001614_abnormal_blood_vessel0.69291031
100MP0001348_abnormal_lacrimal_gland0.68008040

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.38412727
2Eczematoid dermatitis (HP:0000976)3.31880863
3Premature rupture of membranes (HP:0001788)3.31429609
4Abnormality of glycosphingolipid metabolism (HP:0004343)3.22126688
5Abnormality of glycolipid metabolism (HP:0010969)3.22126688
6Abnormality of liposaccharide metabolism (HP:0010968)3.22126688
7Dysostosis multiplex (HP:0000943)3.12913647
8Abnormality of macrophages (HP:0004311)3.07638594
9Cerebral aneurysm (HP:0004944)2.95694567
10Vertebral compression fractures (HP:0002953)2.83352414
11J-shaped sella turcica (HP:0002680)2.79036156
12Flat acetabular roof (HP:0003180)2.76036573
13Cervical subluxation (HP:0003308)2.75081384
14Urinary glycosaminoglycan excretion (HP:0003541)2.70208475
15Mucopolysacchariduria (HP:0008155)2.70208475
16Abnormality of mucopolysaccharide metabolism (HP:0011020)2.67015115
17Abnormality of polysaccharide metabolism (HP:0011012)2.67015115
18Abnormality of glycosaminoglycan metabolism (HP:0004371)2.67015115
19Thin bony cortex (HP:0002753)2.58785786
20Hemorrhage of the eye (HP:0011885)2.55047264
21Obstructive sleep apnea (HP:0002870)2.54944654
22Distal upper limb amyotrophy (HP:0007149)2.53027441
23Upper limb amyotrophy (HP:0009129)2.53027441
24Broad face (HP:0000283)2.46621068
25Increased cerebral lipofuscin (HP:0011813)2.45010813
26Hyperacusis (HP:0010780)2.42505625
27Achilles tendon contracture (HP:0001771)2.38191874
28Disproportionate tall stature (HP:0001519)2.33216829
29Recurrent abscess formation (HP:0002722)2.30564612
30Abnormality of the Achilles tendon (HP:0005109)2.29328775
31Loss of speech (HP:0002371)2.29167248
32Deep venous thrombosis (HP:0002625)2.28084644
33Distal lower limb muscle weakness (HP:0009053)2.26893975
34Blue sclerae (HP:0000592)2.24579002
35Increased connective tissue (HP:0009025)2.19270784
36Systemic lupus erythematosus (HP:0002725)2.19111906
37Vacuolated lymphocytes (HP:0001922)2.17262687
38Distal lower limb amyotrophy (HP:0008944)2.15529793
39Peritonitis (HP:0002586)2.13811673
40Spontaneous hematomas (HP:0007420)2.11717621
41Pathologic fracture (HP:0002756)2.09147142
42Axonal loss (HP:0003447)2.07949006
43Purpura (HP:0000979)2.07112061
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.05981709
45Recurrent bacterial skin infections (HP:0005406)2.04823561
46Shallow orbits (HP:0000586)2.04060511
47Stridor (HP:0010307)2.03322799
48Aneurysm (HP:0002617)2.03175988
49Cellulitis (HP:0100658)2.03120623
50Myocardial infarction (HP:0001658)2.00395763
51Asymmetric septal hypertrophy (HP:0001670)2.00109344
52Obstructive lung disease (HP:0006536)1.98817336
53Chronic obstructive pulmonary disease (HP:0006510)1.98817336
54Gingivitis (HP:0000230)1.98685877
55Ulnar bowing (HP:0003031)1.96545073
56Increased variability in muscle fiber diameter (HP:0003557)1.95867950
57Recurrent gram-negative bacterial infections (HP:0005420)1.95740149
58Hand muscle atrophy (HP:0009130)1.92264814
59Malnutrition (HP:0004395)1.92020625
60Dilatation of the ascending aorta (HP:0005111)1.90449231
61Nuclear cataract (HP:0100018)1.88913724
62Mitral regurgitation (HP:0001653)1.88675481
63Abnormality of the nasal mucosa (HP:0000433)1.88497607
64Genu recurvatum (HP:0002816)1.88284048
65Myositis (HP:0100614)1.84271983
66Broad metatarsal (HP:0001783)1.83535199
67Polycythemia (HP:0001901)1.83129542
68Fragile skin (HP:0001030)1.82978128
69Centrally nucleated skeletal muscle fibers (HP:0003687)1.81411740
70Polygenic inheritance (HP:0010982)1.80956608
71Abnormal vertebral ossification (HP:0100569)1.79904791
72Ankle contracture (HP:0006466)1.79827656
73Joint stiffness (HP:0001387)1.79643222
74Esophageal varix (HP:0002040)1.79420368
75Amyloidosis (HP:0011034)1.79371215
76Bone pain (HP:0002653)1.78825583
77Orchitis (HP:0100796)1.78573465
78Interstitial pulmonary disease (HP:0006530)1.76746367
79Segmental peripheral demyelination/remyelination (HP:0003481)1.75427021
80Abnormality of the thoracic spine (HP:0100711)1.74989474
81Biconcave vertebral bodies (HP:0004586)1.74338177
82Abnormality of skeletal muscle fiber size (HP:0012084)1.71320450
83Gastrointestinal infarctions (HP:0005244)1.70533633
84Flared iliac wings (HP:0002869)1.70239804
85Easy fatigability (HP:0003388)1.70124814
86Long toe (HP:0010511)1.70049976
87Abdominal distention (HP:0003270)1.69267489
88Xanthomatosis (HP:0000991)1.67506716
89Spinal rigidity (HP:0003306)1.66961222
90Bulbar palsy (HP:0001283)1.66666137
91Coxa vara (HP:0002812)1.66460761
92Deformed sella turcica (HP:0002681)1.66414675
93Nonimmune hydrops fetalis (HP:0001790)1.65457876
94Arterial tortuosity (HP:0005116)1.65444193
95Vascular tortuosity (HP:0004948)1.65200558
96Mildly elevated creatine phosphokinase (HP:0008180)1.65181081
97Abnormality of the distal phalanges of the toes (HP:0010182)1.64486325
98Emphysema (HP:0002097)1.64044457
99Cerebral inclusion bodies (HP:0100314)1.63722542
100Lymphangioma (HP:0100764)1.63064480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.50913832
2ERN13.60751406
3SIK13.27342487
4IRAK32.85586413
5PRPF4B2.74005308
6SMG12.59640132
7FGFR42.19741829
8MAP2K32.15487319
9EPHA22.06318603
10RIPK12.04709412
11MAP4K11.91275270
12PKN21.90401245
13ICK1.90238327
14MAP3K31.82388042
15EPHB11.82037394
16TAOK11.76630858
17IRAK41.63947865
18PAK41.63098387
19MAP3K111.61608067
20RIPK41.58848773
21EEF2K1.56396134
22PTK61.52134977
23TTN1.46564807
24TAOK21.44410480
25TESK11.40789015
26PRKD21.39300544
27ZAP701.35820253
28MAP3K101.34159135
29PDGFRA1.31418875
30TYK21.28804414
31CDC42BPA1.28775116
32MARK21.20691320
33CSK1.20634477
34MAP3K11.20067135
35NME21.15202904
36LMTK21.14683018
37TBK11.13949416
38DDR21.12931490
39PDPK11.12556851
40PTK21.11902803
41TESK21.11360541
42PRKG21.10368151
43MAP3K131.08143045
44KSR21.07799236
45GRK61.07764358
46IRAK21.05365418
47MST1R1.00885510
48RPS6KA20.95314484
49CDK120.92175857
50BMX0.91150112
51BLK0.90771531
52TNK20.90080071
53JAK30.83986081
54TGFBR20.79220957
55MTOR0.78959047
56EPHB20.78057543
57LRRK20.77016222
58PRKD30.75919509
59TYRO30.72911930
60RPS6KL10.71361607
61RPS6KC10.71361607
62FGR0.68303720
63FES0.68166626
64KDR0.68143917
65PDK10.67949048
66MAP3K60.67408954
67FGFR30.65002389
68ARAF0.64111157
69MAP3K140.62374422
70DYRK1B0.61672634
71MAP3K80.61658733
72STK380.61453716
73MAP2K20.61009340
74SIK30.60771253
75CAMK1D0.60457767
76HCK0.60154639
77HIPK20.57436068
78BTK0.55508725
79RET0.52732500
80RPS6KA60.49021327
81PDGFRB0.48936198
82MATK0.47838036
83MAP3K20.46645918
84IRAK10.46221666
85MAP3K70.45826604
86MAPK110.45365694
87MAPK120.45077140
88JAK10.42054044
89NTRK10.41152039
90CSF1R0.40414897
91ILK0.40239311
92CHUK0.39167971
93BRAF0.38172122
94IKBKE0.36375845
95MET0.35785939
96TIE10.35107647
97SGK30.34810296
98MAPKAPK20.34761611
99MAPK70.32555868
100SIK20.31867194

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.52541600
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.68848914
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.41713493
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.22375815
5Acute myeloid leukemia_Homo sapiens_hsa052211.83108749
6Osteoclast differentiation_Homo sapiens_hsa043801.82363243
7Notch signaling pathway_Homo sapiens_hsa043301.80123848
8Lysosome_Homo sapiens_hsa041421.73884602
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62125666
10Chronic myeloid leukemia_Homo sapiens_hsa052201.58474548
11Galactose metabolism_Homo sapiens_hsa000521.55468003
12VEGF signaling pathway_Homo sapiens_hsa043701.50296734
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.47679855
14Leishmaniasis_Homo sapiens_hsa051401.43777894
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42598618
16B cell receptor signaling pathway_Homo sapiens_hsa046621.42419451
17Bladder cancer_Homo sapiens_hsa052191.41704333
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31687254
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23089311
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.22902201
21Prion diseases_Homo sapiens_hsa050201.22374712
22Non-small cell lung cancer_Homo sapiens_hsa052231.20952696
23Fructose and mannose metabolism_Homo sapiens_hsa000511.20392896
24Hepatitis C_Homo sapiens_hsa051601.20187888
25Amoebiasis_Homo sapiens_hsa051461.19565522
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16705985
27Renal cell carcinoma_Homo sapiens_hsa052111.16446536
28Toxoplasmosis_Homo sapiens_hsa051451.15586669
29Staphylococcus aureus infection_Homo sapiens_hsa051501.14616738
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13660865
31Pancreatic cancer_Homo sapiens_hsa052121.13312472
32TNF signaling pathway_Homo sapiens_hsa046681.12801368
33Endometrial cancer_Homo sapiens_hsa052131.11235010
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.10556994
35Tuberculosis_Homo sapiens_hsa051521.10120269
36Malaria_Homo sapiens_hsa051441.06939242
37Focal adhesion_Homo sapiens_hsa045101.06188052
38Salmonella infection_Homo sapiens_hsa051321.01963829
39Neurotrophin signaling pathway_Homo sapiens_hsa047220.99756519
40Endocytosis_Homo sapiens_hsa041440.97470336
41Insulin signaling pathway_Homo sapiens_hsa049100.97185648
42Influenza A_Homo sapiens_hsa051640.96533965
43Thyroid cancer_Homo sapiens_hsa052160.94795801
44Pentose phosphate pathway_Homo sapiens_hsa000300.94674400
45Shigellosis_Homo sapiens_hsa051310.94529648
46Proteoglycans in cancer_Homo sapiens_hsa052050.94015412
47Vibrio cholerae infection_Homo sapiens_hsa051100.92865488
48Insulin resistance_Homo sapiens_hsa049310.92143037
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92098270
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.91414116
51Chemokine signaling pathway_Homo sapiens_hsa040620.91212985
52Prolactin signaling pathway_Homo sapiens_hsa049170.90037989
53Hepatitis B_Homo sapiens_hsa051610.89986051
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88243947
55Pertussis_Homo sapiens_hsa051330.87508100
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.85604286
57GnRH signaling pathway_Homo sapiens_hsa049120.84750706
58Apoptosis_Homo sapiens_hsa042100.83569478
59T cell receptor signaling pathway_Homo sapiens_hsa046600.81566104
60Phagosome_Homo sapiens_hsa041450.80428979
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.80370104
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80034130
63Prostate cancer_Homo sapiens_hsa052150.79601598
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.78246391
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77381408
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76924858
67mTOR signaling pathway_Homo sapiens_hsa041500.76308278
68Choline metabolism in cancer_Homo sapiens_hsa052310.75957654
69Platelet activation_Homo sapiens_hsa046110.74749321
70Complement and coagulation cascades_Homo sapiens_hsa046100.74250248
71ErbB signaling pathway_Homo sapiens_hsa040120.74201488
72Small cell lung cancer_Homo sapiens_hsa052220.72844361
73Estrogen signaling pathway_Homo sapiens_hsa049150.72764338
74HIF-1 signaling pathway_Homo sapiens_hsa040660.71315558
75Measles_Homo sapiens_hsa051620.70808762
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70017707
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69798453
78ECM-receptor interaction_Homo sapiens_hsa045120.69518963
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65570868
80Glioma_Homo sapiens_hsa052140.62744295
81Rap1 signaling pathway_Homo sapiens_hsa040150.62697715
82Adherens junction_Homo sapiens_hsa045200.62430982
83Sphingolipid metabolism_Homo sapiens_hsa006000.59884612
84Protein digestion and absorption_Homo sapiens_hsa049740.59791974
85Viral myocarditis_Homo sapiens_hsa054160.59548551
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59461359
87AMPK signaling pathway_Homo sapiens_hsa041520.59193829
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58795050
89Renin-angiotensin system_Homo sapiens_hsa046140.58264761
90Inositol phosphate metabolism_Homo sapiens_hsa005620.57723127
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57718823
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57097466
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55860453
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.54535252
95African trypanosomiasis_Homo sapiens_hsa051430.53515480
96Colorectal cancer_Homo sapiens_hsa052100.52768305
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51635252
98HTLV-I infection_Homo sapiens_hsa051660.50014107
99Legionellosis_Homo sapiens_hsa051340.48686911
100Vitamin digestion and absorption_Homo sapiens_hsa049770.46832750

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