

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.35177394 |
| 2 | vocalization behavior (GO:0071625) | 5.22475205 |
| 3 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.19483169 |
| 4 | locomotory exploration behavior (GO:0035641) | 5.00372383 |
| 5 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.97926408 |
| 6 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.73386176 |
| 7 | synaptic vesicle maturation (GO:0016188) | 4.69518379 |
| 8 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.66275350 |
| 9 | neuron cell-cell adhesion (GO:0007158) | 4.50666767 |
| 10 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.47223448 |
| 11 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.46858718 |
| 12 | synaptic vesicle exocytosis (GO:0016079) | 4.46171418 |
| 13 | protein localization to synapse (GO:0035418) | 4.45379463 |
| 14 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.36980795 |
| 15 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.31173332 |
| 16 | glutamate secretion (GO:0014047) | 4.24208240 |
| 17 | dendritic spine morphogenesis (GO:0060997) | 4.04081398 |
| 18 | neuronal action potential propagation (GO:0019227) | 4.03760349 |
| 19 | exploration behavior (GO:0035640) | 4.01266040 |
| 20 | glutamate receptor signaling pathway (GO:0007215) | 3.99261016 |
| 21 | regulation of synaptic vesicle transport (GO:1902803) | 3.98039041 |
| 22 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.93030159 |
| 23 | synaptic transmission, glutamatergic (GO:0035249) | 3.92511201 |
| 24 | regulation of synapse structural plasticity (GO:0051823) | 3.90812399 |
| 25 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.87900807 |
| 26 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.86853887 |
| 27 | neuron recognition (GO:0008038) | 3.81411531 |
| 28 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.78853974 |
| 29 | nucleobase catabolic process (GO:0046113) | 3.70589236 |
| 30 | layer formation in cerebral cortex (GO:0021819) | 3.68944075 |
| 31 | neuron-neuron synaptic transmission (GO:0007270) | 3.67441311 |
| 32 | neurotransmitter secretion (GO:0007269) | 3.61162651 |
| 33 | long-term memory (GO:0007616) | 3.56397594 |
| 34 | proline transport (GO:0015824) | 3.54369197 |
| 35 | axonal fasciculation (GO:0007413) | 3.54112810 |
| 36 | synaptic vesicle endocytosis (GO:0048488) | 3.53563221 |
| 37 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.49645909 |
| 38 | postsynaptic membrane organization (GO:0001941) | 3.41683116 |
| 39 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.40640858 |
| 40 | positive regulation of membrane potential (GO:0045838) | 3.36406876 |
| 41 | regulation of postsynaptic membrane potential (GO:0060078) | 3.34114104 |
| 42 | behavioral response to nicotine (GO:0035095) | 3.34027737 |
| 43 | presynaptic membrane assembly (GO:0097105) | 3.31778333 |
| 44 | gamma-aminobutyric acid transport (GO:0015812) | 3.26874186 |
| 45 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.26812234 |
| 46 | establishment of mitochondrion localization (GO:0051654) | 3.26770229 |
| 47 | membrane depolarization during action potential (GO:0086010) | 3.25738118 |
| 48 | transmission of nerve impulse (GO:0019226) | 3.24440010 |
| 49 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.24105004 |
| 50 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.23924124 |
| 51 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.23480463 |
| 52 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.21210420 |
| 53 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.20119209 |
| 54 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.17067691 |
| 55 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.16465468 |
| 56 | central nervous system myelination (GO:0022010) | 3.16376639 |
| 57 | axon ensheathment in central nervous system (GO:0032291) | 3.16376639 |
| 58 | neuronal ion channel clustering (GO:0045161) | 3.15691588 |
| 59 | regulation of synaptic plasticity (GO:0048167) | 3.14962749 |
| 60 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.13384560 |
| 61 | regulation of neurotransmitter secretion (GO:0046928) | 3.13280437 |
| 62 | cellular potassium ion homeostasis (GO:0030007) | 3.13244592 |
| 63 | presynaptic membrane organization (GO:0097090) | 3.12330796 |
| 64 | detection of calcium ion (GO:0005513) | 3.12096736 |
| 65 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.12026227 |
| 66 | neuromuscular synaptic transmission (GO:0007274) | 3.09664955 |
| 67 | cell communication by electrical coupling (GO:0010644) | 3.09183169 |
| 68 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.09180123 |
| 69 | positive regulation of synapse maturation (GO:0090129) | 3.08697744 |
| 70 | neurotransmitter transport (GO:0006836) | 3.08560665 |
| 71 | activation of protein kinase A activity (GO:0034199) | 3.08077029 |
| 72 | membrane depolarization (GO:0051899) | 3.05363259 |
| 73 | dendritic spine organization (GO:0097061) | 3.02318241 |
| 74 | auditory behavior (GO:0031223) | 3.00873398 |
| 75 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.99736898 |
| 76 | synapse assembly (GO:0007416) | 2.97047514 |
| 77 | response to auditory stimulus (GO:0010996) | 2.94803080 |
| 78 | dendrite morphogenesis (GO:0048813) | 2.94770232 |
| 79 | long-term synaptic potentiation (GO:0060291) | 2.94677301 |
| 80 | positive regulation of synapse assembly (GO:0051965) | 2.94573842 |
| 81 | positive regulation of neurotransmitter transport (GO:0051590) | 2.94337518 |
| 82 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.93822751 |
| 83 | cerebellar granule cell differentiation (GO:0021707) | 2.92490620 |
| 84 | regulation of vesicle fusion (GO:0031338) | 2.92234918 |
| 85 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.91334821 |
| 86 | innervation (GO:0060384) | 2.90732415 |
| 87 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.90456715 |
| 88 | spinal cord development (GO:0021510) | 2.88294450 |
| 89 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.87493152 |
| 90 | regulation of neurotransmitter transport (GO:0051588) | 2.87349072 |
| 91 | learning (GO:0007612) | 2.86657055 |
| 92 | retinal ganglion cell axon guidance (GO:0031290) | 2.86257468 |
| 93 | cell migration in hindbrain (GO:0021535) | 2.85693064 |
| 94 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.84923281 |
| 95 | regulation of dendritic spine development (GO:0060998) | 2.83819142 |
| 96 | membrane hyperpolarization (GO:0060081) | 2.83531472 |
| 97 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.83073625 |
| 98 | behavioral fear response (GO:0001662) | 2.81206183 |
| 99 | behavioral defense response (GO:0002209) | 2.81206183 |
| 100 | glycine transport (GO:0015816) | 2.81169180 |
| 101 | neuromuscular process controlling balance (GO:0050885) | 2.80310593 |
| 102 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.80215027 |
| 103 | mitochondrion transport along microtubule (GO:0047497) | 2.80215027 |
| 104 | positive regulation of dendritic spine development (GO:0060999) | 2.79766887 |
| 105 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.79395817 |
| 106 | regulation of neurotransmitter levels (GO:0001505) | 2.78625704 |
| 107 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.78394064 |
| 108 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.76921856 |
| 109 | vesicle transport along microtubule (GO:0047496) | 2.76685797 |
| 110 | response to histamine (GO:0034776) | 2.74076005 |
| 111 | regulation of synaptic transmission (GO:0050804) | 2.73819425 |
| 112 | axon extension (GO:0048675) | 2.72307524 |
| 113 | synaptic transmission (GO:0007268) | 2.72200502 |
| 114 | startle response (GO:0001964) | 2.71831576 |
| 115 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.70900233 |
| 116 | synapse organization (GO:0050808) | 2.70589703 |
| 117 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.70211241 |
| 118 | regulation of synapse maturation (GO:0090128) | 2.69585813 |
| 119 | regulation of respiratory system process (GO:0044065) | 2.62869982 |
| 120 | epithelial cilium movement (GO:0003351) | 2.59141620 |
| 121 | short-term memory (GO:0007614) | 2.57706888 |
| 122 | mechanosensory behavior (GO:0007638) | 2.56638751 |
| 123 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.56336197 |
| 124 | nonmotile primary cilium assembly (GO:0035058) | 2.51373564 |
| 125 | chemosensory behavior (GO:0007635) | 2.50850603 |
| 126 | cerebellar Purkinje cell layer development (GO:0021680) | 2.50376521 |
| 127 | negative regulation of axon extension (GO:0030517) | 2.47770175 |
| 128 | regulation of membrane repolarization (GO:0060306) | 2.45629420 |
| 129 | membrane repolarization (GO:0086009) | 2.42163828 |
| 130 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.37607927 |
| 131 | negative regulation of axonogenesis (GO:0050771) | 2.35595990 |
| 132 | cilium movement (GO:0003341) | 2.34902039 |
| 133 | regulation of synapse organization (GO:0050807) | 2.34078949 |
| 134 | regulation of synapse assembly (GO:0051963) | 2.33835030 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.02378440 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.57199480 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.98769299 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.98720563 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.86585627 |
| 6 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.63729910 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.63729910 |
| 8 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.57916744 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.52487041 |
| 10 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.48491429 |
| 11 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.46915933 |
| 12 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.43192639 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.40188220 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.37887923 |
| 15 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.35852762 |
| 16 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.32294549 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.28549728 |
| 18 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.25399199 |
| 19 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.20799872 |
| 20 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.15995477 |
| 21 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.10459873 |
| 22 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.07344467 |
| 23 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.95150801 |
| 24 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.90208487 |
| 25 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.86666786 |
| 26 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.80585144 |
| 27 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.73238145 |
| 28 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.70403096 |
| 29 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.63687419 |
| 30 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.63424432 |
| 31 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.63079466 |
| 32 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.62832594 |
| 33 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.60876420 |
| 34 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.60168204 |
| 35 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.60137740 |
| 36 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.57317725 |
| 37 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.52311926 |
| 38 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.51916710 |
| 39 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.48727787 |
| 40 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.47554849 |
| 41 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.47202224 |
| 42 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.46761923 |
| 43 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.45551195 |
| 44 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.44150607 |
| 45 | P300_19829295_ChIP-Seq_ESCs_Human | 1.42905119 |
| 46 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.40259488 |
| 47 | * CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.40231959 |
| 48 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.37665642 |
| 49 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.37448631 |
| 50 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.36755813 |
| 51 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.34661677 |
| 52 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.31240250 |
| 53 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.31091877 |
| 54 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.30079884 |
| 55 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.28610467 |
| 56 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.28539919 |
| 57 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.26938988 |
| 58 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.25994523 |
| 59 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.25621574 |
| 60 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.25531770 |
| 61 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.23394174 |
| 62 | AR_25329375_ChIP-Seq_VCAP_Human | 1.23104909 |
| 63 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.22481342 |
| 64 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.22169979 |
| 65 | STAT3_23295773_ChIP-Seq_U87_Human | 1.21098973 |
| 66 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.20210674 |
| 67 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.19985662 |
| 68 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.18712925 |
| 69 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.17212318 |
| 70 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.17163750 |
| 71 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.15543871 |
| 72 | TCF4_23295773_ChIP-Seq_U87_Human | 1.14677075 |
| 73 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.14643077 |
| 74 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.13730911 |
| 75 | AR_19668381_ChIP-Seq_PC3_Human | 1.13322978 |
| 76 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.11973768 |
| 77 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.11714985 |
| 78 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.10887825 |
| 79 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.10868205 |
| 80 | VDR_22108803_ChIP-Seq_LS180_Human | 1.09752434 |
| 81 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.09717070 |
| 82 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.09289719 |
| 83 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.08637137 |
| 84 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08637137 |
| 85 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.05835122 |
| 86 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.05801280 |
| 87 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.05441851 |
| 88 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.04797878 |
| 89 | KDM2B_26808549_Chip-Seq_K562_Human | 1.04369874 |
| 90 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.03253697 |
| 91 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.02715293 |
| 92 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.01721929 |
| 93 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.01583527 |
| 94 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.01391183 |
| 95 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99792471 |
| 96 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.99639490 |
| 97 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.99634549 |
| 98 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.98641166 |
| 99 | FUS_26573619_Chip-Seq_HEK293_Human | 0.98248173 |
| 100 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.97852716 |
| 101 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.97303611 |
| 102 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96805055 |
| 103 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.96627256 |
| 104 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.95922582 |
| 105 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.95064339 |
| 106 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.94784238 |
| 107 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.94174499 |
| 108 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.92168132 |
| 109 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.92101944 |
| 110 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.91074972 |
| 111 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.91052637 |
| 112 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.91005148 |
| 113 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.88857640 |
| 114 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.88621003 |
| 115 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.88173754 |
| 116 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.87994236 |
| 117 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.86256884 |
| 118 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.85921071 |
| 119 | TP53_16413492_ChIP-PET_HCT116_Human | 0.85672135 |
| 120 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.85639426 |
| 121 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.85066613 |
| 122 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.83083423 |
| 123 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.81697857 |
| 124 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81443862 |
| 125 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.79208039 |
| 126 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.78412606 |
| 127 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.76724594 |
| 128 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.75749177 |
| 129 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.75031066 |
| 130 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.72451900 |
| 131 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.70884907 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.80526531 |
| 2 | MP0003880_abnormal_central_pattern | 4.64695873 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.76742098 |
| 4 | MP0004270_analgesia | 3.33121181 |
| 5 | MP0009745_abnormal_behavioral_response | 3.18207539 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.05830792 |
| 7 | MP0002064_seizures | 2.90685700 |
| 8 | MP0005423_abnormal_somatic_nervous | 2.89718000 |
| 9 | MP0001968_abnormal_touch/_nociception | 2.76191677 |
| 10 | MP0009046_muscle_twitch | 2.72767651 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.65940895 |
| 12 | MP0001486_abnormal_startle_reflex | 2.55925764 |
| 13 | MP0002653_abnormal_ependyma_morphology | 2.47665293 |
| 14 | MP0002272_abnormal_nervous_system | 2.44351182 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.39967418 |
| 16 | MP0002822_catalepsy | 2.18901927 |
| 17 | MP0002735_abnormal_chemical_nociception | 2.18621476 |
| 18 | MP0001501_abnormal_sleep_pattern | 2.16101799 |
| 19 | MP0002736_abnormal_nociception_after | 2.15812391 |
| 20 | MP0001440_abnormal_grooming_behavior | 2.12721277 |
| 21 | MP0006276_abnormal_autonomic_nervous | 1.96196851 |
| 22 | MP0000778_abnormal_nervous_system | 1.92423712 |
| 23 | MP0002837_dystrophic_cardiac_calcinosis | 1.90714941 |
| 24 | MP0002733_abnormal_thermal_nociception | 1.90315001 |
| 25 | MP0002067_abnormal_sensory_capabilities | 1.88047259 |
| 26 | MP0009780_abnormal_chondrocyte_physiolo | 1.85920294 |
| 27 | MP0001970_abnormal_pain_threshold | 1.85082411 |
| 28 | MP0003283_abnormal_digestive_organ | 1.79918495 |
| 29 | MP0003121_genomic_imprinting | 1.77763665 |
| 30 | MP0002184_abnormal_innervation | 1.77140423 |
| 31 | MP0005646_abnormal_pituitary_gland | 1.76583752 |
| 32 | MP0005386_behavior/neurological_phenoty | 1.74844926 |
| 33 | MP0004924_abnormal_behavior | 1.74844926 |
| 34 | MP0000751_myopathy | 1.72375347 |
| 35 | MP0002557_abnormal_social/conspecific_i | 1.71222273 |
| 36 | MP0005645_abnormal_hypothalamus_physiol | 1.70203032 |
| 37 | MP0003879_abnormal_hair_cell | 1.63001888 |
| 38 | MP0008569_lethality_at_weaning | 1.61513142 |
| 39 | MP0004811_abnormal_neuron_physiology | 1.52787206 |
| 40 | MP0004858_abnormal_nervous_system | 1.50775039 |
| 41 | MP0003787_abnormal_imprinting | 1.49312371 |
| 42 | MP0003123_paternal_imprinting | 1.48822337 |
| 43 | MP0002909_abnormal_adrenal_gland | 1.45250847 |
| 44 | MP0000955_abnormal_spinal_cord | 1.45006680 |
| 45 | MP0001984_abnormal_olfaction | 1.41095538 |
| 46 | MP0004133_heterotaxia | 1.39892923 |
| 47 | MP0001529_abnormal_vocalization | 1.38624850 |
| 48 | MP0003646_muscle_fatigue | 1.36119110 |
| 49 | MP0002882_abnormal_neuron_morphology | 1.36000974 |
| 50 | MP0001502_abnormal_circadian_rhythm | 1.35917029 |
| 51 | MP0004885_abnormal_endolymph | 1.35501575 |
| 52 | MP0002066_abnormal_motor_capabilities/c | 1.34386936 |
| 53 | MP0002249_abnormal_larynx_morphology | 1.33253201 |
| 54 | MP0003329_amyloid_beta_deposits | 1.31382412 |
| 55 | MP0004215_abnormal_myocardial_fiber | 1.30654240 |
| 56 | MP0003122_maternal_imprinting | 1.28520060 |
| 57 | MP0003136_yellow_coat_color | 1.25724925 |
| 58 | MP0004145_abnormal_muscle_electrophysio | 1.25118585 |
| 59 | MP0005377_hearing/vestibular/ear_phenot | 1.23685294 |
| 60 | MP0003878_abnormal_ear_physiology | 1.23685294 |
| 61 | MP0001188_hyperpigmentation | 1.23634309 |
| 62 | MP0004742_abnormal_vestibular_system | 1.21057131 |
| 63 | MP0004085_abnormal_heartbeat | 1.15792140 |
| 64 | MP0000566_synostosis | 1.15414158 |
| 65 | MP0000049_abnormal_middle_ear | 1.13574287 |
| 66 | MP0003633_abnormal_nervous_system | 1.13503699 |
| 67 | MP0001905_abnormal_dopamine_level | 1.13176002 |
| 68 | MP0004142_abnormal_muscle_tone | 1.10791764 |
| 69 | MP0003137_abnormal_impulse_conducting | 1.09654159 |
| 70 | MP0008789_abnormal_olfactory_epithelium | 1.08902460 |
| 71 | MP0002152_abnormal_brain_morphology | 1.05863087 |
| 72 | MP0003938_abnormal_ear_development | 1.05080603 |
| 73 | MP0003861_abnormal_nervous_system | 1.01459060 |
| 74 | MP0001299_abnormal_eye_distance/ | 1.00032459 |
| 75 | MP0008877_abnormal_DNA_methylation | 0.99745938 |
| 76 | MP0009379_abnormal_foot_pigmentation | 0.99620507 |
| 77 | MP0010386_abnormal_urinary_bladder | 0.96993991 |
| 78 | MP0004484_altered_response_of | 0.96460942 |
| 79 | MP0005409_darkened_coat_color | 0.95622722 |
| 80 | MP0006292_abnormal_olfactory_placode | 0.94253359 |
| 81 | MP0003631_nervous_system_phenotype | 0.94223582 |
| 82 | MP0000631_abnormal_neuroendocrine_gland | 0.93803640 |
| 83 | MP0005551_abnormal_eye_electrophysiolog | 0.93590755 |
| 84 | MP0003942_abnormal_urinary_system | 0.91552496 |
| 85 | MP0002638_abnormal_pupillary_reflex | 0.91211104 |
| 86 | MP0010030_abnormal_orbit_morphology | 0.90843908 |
| 87 | MP0002938_white_spotting | 0.88995901 |
| 88 | MP0002229_neurodegeneration | 0.88838286 |
| 89 | MP0001485_abnormal_pinna_reflex | 0.88712917 |
| 90 | MP0001963_abnormal_hearing_physiology | 0.88100234 |
| 91 | MP0002069_abnormal_eating/drinking_beha | 0.87964005 |
| 92 | MP0004510_myositis | 0.87014843 |
| 93 | MP0003119_abnormal_digestive_system | 0.85218822 |
| 94 | MP0004036_abnormal_muscle_relaxation | 0.83340984 |
| 95 | MP0001177_atelectasis | 0.82628557 |
| 96 | MP0000534_abnormal_ureter_morphology | 0.82578393 |
| 97 | MP0005535_abnormal_body_temperature | 0.81217885 |
| 98 | MP0002752_abnormal_somatic_nervous | 0.80935530 |
| 99 | MP0002234_abnormal_pharynx_morphology | 0.80789147 |
| 100 | MP0003634_abnormal_glial_cell | 0.80468985 |
| 101 | MP0000569_abnormal_digit_pigmentation | 0.78109171 |
| 102 | MP0008874_decreased_physiological_sensi | 0.76751372 |
| 103 | MP0005620_abnormal_muscle_contractility | 0.76375245 |
| 104 | MP0008961_abnormal_basal_metabolism | 0.76145027 |
| 105 | MP0000920_abnormal_myelination | 0.74423389 |
| 106 | MP0004233_abnormal_muscle_weight | 0.73595866 |
| 107 | MP0005503_abnormal_tendon_morphology | 0.72894624 |
| 108 | MP0001346_abnormal_lacrimal_gland | 0.71965113 |
| 109 | MP0005410_abnormal_fertilization | 0.71871595 |
| 110 | MP0005499_abnormal_olfactory_system | 0.70517687 |
| 111 | MP0005394_taste/olfaction_phenotype | 0.70517687 |
| 112 | MP0005253_abnormal_eye_physiology | 0.70369350 |
| 113 | MP0000013_abnormal_adipose_tissue | 0.69732227 |
| 114 | MP0005195_abnormal_posterior_eye | 0.69432177 |
| 115 | MP0002972_abnormal_cardiac_muscle | 0.67637630 |
| 116 | MP0001664_abnormal_digestion | 0.67551585 |
| 117 | MP0004130_abnormal_muscle_cell | 0.67054463 |
| 118 | MP0000026_abnormal_inner_ear | 0.66631585 |
| 119 | MP0004043_abnormal_pH_regulation | 0.64603654 |
| 120 | MP0003690_abnormal_glial_cell | 0.63378667 |
| 121 | MP0008872_abnormal_physiological_respon | 0.63014029 |
| 122 | MP0004084_abnormal_cardiac_muscle | 0.62915489 |
| 123 | MP0000749_muscle_degeneration | 0.61272973 |
| 124 | MP0006072_abnormal_retinal_apoptosis | 0.61189477 |
| 125 | MP0003632_abnormal_nervous_system | 0.59749692 |
| 126 | MP0002876_abnormal_thyroid_physiology | 0.58812523 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.90965694 |
| 2 | Myokymia (HP:0002411) | 5.97365690 |
| 3 | Focal seizures (HP:0007359) | 5.07713959 |
| 4 | Visual hallucinations (HP:0002367) | 4.57434128 |
| 5 | Febrile seizures (HP:0002373) | 4.55328316 |
| 6 | Epileptic encephalopathy (HP:0200134) | 4.39536693 |
| 7 | Atonic seizures (HP:0010819) | 4.09955586 |
| 8 | Progressive cerebellar ataxia (HP:0002073) | 3.89257592 |
| 9 | Broad-based gait (HP:0002136) | 3.58003335 |
| 10 | Absence seizures (HP:0002121) | 3.57374060 |
| 11 | Generalized tonic-clonic seizures (HP:0002069) | 3.56874902 |
| 12 | Hyperventilation (HP:0002883) | 3.46347436 |
| 13 | Action tremor (HP:0002345) | 3.44708697 |
| 14 | Supranuclear gaze palsy (HP:0000605) | 3.37894965 |
| 15 | Dialeptic seizures (HP:0011146) | 3.30551939 |
| 16 | Poor eye contact (HP:0000817) | 3.27028330 |
| 17 | Sleep apnea (HP:0010535) | 3.05963439 |
| 18 | Absent/shortened dynein arms (HP:0200106) | 2.99886641 |
| 19 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.99886641 |
| 20 | Gaze-evoked nystagmus (HP:0000640) | 2.93067625 |
| 21 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.92697394 |
| 22 | Ankle clonus (HP:0011448) | 2.90473678 |
| 23 | Abnormal social behavior (HP:0012433) | 2.83043786 |
| 24 | Impaired social interactions (HP:0000735) | 2.83043786 |
| 25 | Gait imbalance (HP:0002141) | 2.82926200 |
| 26 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.79783200 |
| 27 | Dysdiadochokinesis (HP:0002075) | 2.77078390 |
| 28 | Depression (HP:0000716) | 2.76738179 |
| 29 | Anxiety (HP:0000739) | 2.74156517 |
| 30 | Truncal ataxia (HP:0002078) | 2.71480348 |
| 31 | Nephronophthisis (HP:0000090) | 2.68265801 |
| 32 | Drooling (HP:0002307) | 2.67054189 |
| 33 | Excessive salivation (HP:0003781) | 2.67054189 |
| 34 | True hermaphroditism (HP:0010459) | 2.64804193 |
| 35 | Amblyopia (HP:0000646) | 2.64185607 |
| 36 | Dysmetria (HP:0001310) | 2.63714841 |
| 37 | Hemiparesis (HP:0001269) | 2.58129280 |
| 38 | Abnormality of the aortic arch (HP:0012303) | 2.56998713 |
| 39 | Postural instability (HP:0002172) | 2.55063192 |
| 40 | Pancreatic fibrosis (HP:0100732) | 2.54911225 |
| 41 | Sudden death (HP:0001699) | 2.54730777 |
| 42 | Molar tooth sign on MRI (HP:0002419) | 2.53030456 |
| 43 | Abnormality of midbrain morphology (HP:0002418) | 2.53030456 |
| 44 | Medial flaring of the eyebrow (HP:0010747) | 2.47076458 |
| 45 | Abnormal eating behavior (HP:0100738) | 2.46776677 |
| 46 | Rib fusion (HP:0000902) | 2.44015236 |
| 47 | Prolonged QT interval (HP:0001657) | 2.43090874 |
| 48 | Absent speech (HP:0001344) | 2.41185507 |
| 49 | Fetal akinesia sequence (HP:0001989) | 2.40034030 |
| 50 | Mutism (HP:0002300) | 2.39962989 |
| 51 | Genetic anticipation (HP:0003743) | 2.39364264 |
| 52 | Obstructive sleep apnea (HP:0002870) | 2.38528721 |
| 53 | Cystic liver disease (HP:0006706) | 2.37971103 |
| 54 | Neurofibrillary tangles (HP:0002185) | 2.36894549 |
| 55 | Abnormal EKG (HP:0003115) | 2.36353634 |
| 56 | Ventricular fibrillation (HP:0001663) | 2.35794341 |
| 57 | Limb dystonia (HP:0002451) | 2.33665456 |
| 58 | Progressive inability to walk (HP:0002505) | 2.32969274 |
| 59 | Cerebral inclusion bodies (HP:0100314) | 2.30827525 |
| 60 | Bundle branch block (HP:0011710) | 2.30345810 |
| 61 | Syncope (HP:0001279) | 2.28594119 |
| 62 | Pheochromocytoma (HP:0002666) | 2.26574239 |
| 63 | Urinary urgency (HP:0000012) | 2.25108337 |
| 64 | Stereotypic behavior (HP:0000733) | 2.24194944 |
| 65 | Exercise-induced myalgia (HP:0003738) | 2.22311070 |
| 66 | Congenital primary aphakia (HP:0007707) | 2.21280692 |
| 67 | Spastic gait (HP:0002064) | 2.18216326 |
| 68 | Termporal pattern (HP:0011008) | 2.14761853 |
| 69 | Insidious onset (HP:0003587) | 2.14761853 |
| 70 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.14666555 |
| 71 | Epileptiform EEG discharges (HP:0011182) | 2.13178038 |
| 72 | Pancreatic cysts (HP:0001737) | 2.13026360 |
| 73 | Lower limb muscle weakness (HP:0007340) | 2.12620076 |
| 74 | Abnormality of the corticospinal tract (HP:0002492) | 2.11374552 |
| 75 | Primary atrial arrhythmia (HP:0001692) | 2.11223270 |
| 76 | Occipital encephalocele (HP:0002085) | 2.08940339 |
| 77 | Atrial fibrillation (HP:0005110) | 2.08521704 |
| 78 | Bradykinesia (HP:0002067) | 2.07868782 |
| 79 | Diplopia (HP:0000651) | 2.07413942 |
| 80 | Abnormality of binocular vision (HP:0011514) | 2.07413942 |
| 81 | Calf muscle hypertrophy (HP:0008981) | 2.06806016 |
| 82 | Abnormality of the renal medulla (HP:0100957) | 2.05973871 |
| 83 | EEG with generalized epileptiform discharges (HP:0011198) | 2.04417965 |
| 84 | Congenital malformation of the right heart (HP:0011723) | 2.04280341 |
| 85 | Double outlet right ventricle (HP:0001719) | 2.04280341 |
| 86 | Inability to walk (HP:0002540) | 2.03711594 |
| 87 | Septo-optic dysplasia (HP:0100842) | 2.00921344 |
| 88 | Specific learning disability (HP:0001328) | 2.00230138 |
| 89 | Type II lissencephaly (HP:0007260) | 1.99865062 |
| 90 | Sclerocornea (HP:0000647) | 1.99140722 |
| 91 | Nephrogenic diabetes insipidus (HP:0009806) | 1.97910015 |
| 92 | Impaired smooth pursuit (HP:0007772) | 1.97640244 |
| 93 | Papilledema (HP:0001085) | 1.96934431 |
| 94 | Pachygyria (HP:0001302) | 1.96822789 |
| 95 | Abnormal ciliary motility (HP:0012262) | 1.95732065 |
| 96 | Torticollis (HP:0000473) | 1.95342973 |
| 97 | Vaginal atresia (HP:0000148) | 1.95332052 |
| 98 | Neuroendocrine neoplasm (HP:0100634) | 1.94810362 |
| 99 | Abnormality of the lower motor neuron (HP:0002366) | 1.93817421 |
| 100 | Impaired vibratory sensation (HP:0002495) | 1.93601381 |
| 101 | Supraventricular tachycardia (HP:0004755) | 1.92983525 |
| 102 | Genital tract atresia (HP:0001827) | 1.92791194 |
| 103 | Turricephaly (HP:0000262) | 1.91693228 |
| 104 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.90518068 |
| 105 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.90518068 |
| 106 | Bronchomalacia (HP:0002780) | 1.90308592 |
| 107 | Agitation (HP:0000713) | 1.90249447 |
| 108 | Polyphagia (HP:0002591) | 1.90113566 |
| 109 | Blue irides (HP:0000635) | 1.90079977 |
| 110 | Hypsarrhythmia (HP:0002521) | 1.90068823 |
| 111 | Focal dystonia (HP:0004373) | 1.89259590 |
| 112 | Intention tremor (HP:0002080) | 1.89045096 |
| 113 | Megalencephaly (HP:0001355) | 1.88613628 |
| 114 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.87916710 |
| 115 | Retinal dysplasia (HP:0007973) | 1.87761092 |
| 116 | Abnormality of salivation (HP:0100755) | 1.86763809 |
| 117 | Lower limb amyotrophy (HP:0007210) | 1.86300534 |
| 118 | Supraventricular arrhythmia (HP:0005115) | 1.85354207 |
| 119 | Hypoventilation (HP:0002791) | 1.84100384 |
| 120 | Abnormality of the labia minora (HP:0012880) | 1.83243385 |
| 121 | Abnormality of the calf musculature (HP:0001430) | 1.82197822 |
| 122 | Generalized myoclonic seizures (HP:0002123) | 1.81209663 |
| 123 | Protruding tongue (HP:0010808) | 1.81066886 |
| 124 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.80574111 |
| 125 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.80574111 |
| 126 | Dysmetric saccades (HP:0000641) | 1.80251778 |
| 127 | Infantile muscular hypotonia (HP:0008947) | 1.79216433 |
| 128 | Spastic tetraplegia (HP:0002510) | 1.78953229 |
| 129 | Scanning speech (HP:0002168) | 1.78591459 |
| 130 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.78464253 |
| 131 | Hemiplegia (HP:0002301) | 1.78420617 |
| 132 | Aplasia involving bones of the extremities (HP:0009825) | 1.77899241 |
| 133 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.77899241 |
| 134 | Aplasia of the phalanges of the hand (HP:0009802) | 1.77899241 |
| 135 | Insomnia (HP:0100785) | 1.77818741 |
| 136 | Lissencephaly (HP:0001339) | 1.76644675 |
| 137 | Myotonia (HP:0002486) | 1.76121235 |
| 138 | Left ventricular hypertrophy (HP:0001712) | 1.73426146 |
| 139 | Optic nerve hypoplasia (HP:0000609) | 1.71183303 |
| 140 | Poor suck (HP:0002033) | 1.70896071 |
| 141 | Renal dysplasia (HP:0000110) | 1.69859886 |
| 142 | Abnormality of the diencephalon (HP:0010662) | 1.68903661 |
| 143 | Hypoplasia of the brainstem (HP:0002365) | 1.68665100 |
| 144 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.68665100 |
| 145 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.67766838 |
| 146 | Shawl scrotum (HP:0000049) | 1.66114880 |
| 147 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.65463337 |
| 148 | Poor coordination (HP:0002370) | 1.63787971 |
| 149 | Failure to thrive in infancy (HP:0001531) | 1.63782001 |
| 150 | Anencephaly (HP:0002323) | 1.63366195 |
| 151 | Tubular atrophy (HP:0000092) | 1.60380624 |
| 152 | Exotropia (HP:0000577) | 1.59941502 |
| 153 | Neoplasm of the heart (HP:0100544) | 1.58877568 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.30832370 |
| 2 | EPHA4 | 4.03590772 |
| 3 | MARK1 | 3.17518088 |
| 4 | MAP3K9 | 3.05233543 |
| 5 | MAP3K4 | 2.73045432 |
| 6 | MAP2K7 | 2.46727184 |
| 7 | PRKD3 | 2.36091884 |
| 8 | MINK1 | 2.31032672 |
| 9 | NTRK2 | 2.16116430 |
| 10 | DAPK2 | 2.15910382 |
| 11 | CASK | 2.15416374 |
| 12 | RIPK4 | 2.08880118 |
| 13 | TNIK | 2.06335901 |
| 14 | MAPK15 | 1.99173316 |
| 15 | PAK6 | 1.98914128 |
| 16 | SIK2 | 1.96779383 |
| 17 | EPHB2 | 1.88783971 |
| 18 | WNK3 | 1.87496065 |
| 19 | MAP3K12 | 1.87358766 |
| 20 | DYRK2 | 1.83671577 |
| 21 | NTRK1 | 1.72159077 |
| 22 | MAP2K4 | 1.68234033 |
| 23 | MAPK13 | 1.61482429 |
| 24 | PHKG1 | 1.57149775 |
| 25 | PHKG2 | 1.57149775 |
| 26 | PNCK | 1.53057432 |
| 27 | PRPF4B | 1.51566027 |
| 28 | PLK2 | 1.47719263 |
| 29 | KSR2 | 1.45608637 |
| 30 | STK38 | 1.41387757 |
| 31 | KSR1 | 1.39991458 |
| 32 | GRK5 | 1.39043970 |
| 33 | CDK5 | 1.39000047 |
| 34 | CAMKK1 | 1.24884778 |
| 35 | DAPK1 | 1.10958222 |
| 36 | CAMK2A | 1.09618303 |
| 37 | LATS2 | 1.08744677 |
| 38 | GRK1 | 1.08335423 |
| 39 | PRKCG | 1.06171418 |
| 40 | FGFR2 | 1.05610218 |
| 41 | UHMK1 | 1.04481636 |
| 42 | CAMK1 | 1.02515309 |
| 43 | FES | 1.01590784 |
| 44 | PTK2B | 1.00947819 |
| 45 | SGK494 | 0.99772177 |
| 46 | SGK223 | 0.99772177 |
| 47 | PINK1 | 0.98413481 |
| 48 | SIK3 | 0.95266994 |
| 49 | DYRK1B | 0.92850343 |
| 50 | ARAF | 0.91370548 |
| 51 | MAP3K13 | 0.89702793 |
| 52 | PAK3 | 0.89491997 |
| 53 | MUSK | 0.88985201 |
| 54 | BMPR2 | 0.88386373 |
| 55 | SGK2 | 0.87959091 |
| 56 | CDK19 | 0.86695643 |
| 57 | LMTK2 | 0.86625519 |
| 58 | MARK2 | 0.86576231 |
| 59 | TYRO3 | 0.86288472 |
| 60 | STK11 | 0.85310105 |
| 61 | BMPR1B | 0.84966828 |
| 62 | PRKD2 | 0.81189262 |
| 63 | BCR | 0.80510971 |
| 64 | CAMK2B | 0.79430853 |
| 65 | EPHA3 | 0.79164451 |
| 66 | SGK1 | 0.79038348 |
| 67 | CAMK1G | 0.76623907 |
| 68 | WNK1 | 0.76218074 |
| 69 | DYRK1A | 0.74957279 |
| 70 | MAP3K2 | 0.74560967 |
| 71 | ICK | 0.74118479 |
| 72 | CDC42BPA | 0.72536802 |
| 73 | SGK3 | 0.71334578 |
| 74 | PRKCH | 0.71211478 |
| 75 | CAMK2D | 0.69412207 |
| 76 | GRK7 | 0.69360019 |
| 77 | TAOK1 | 0.69219426 |
| 78 | PKN1 | 0.68624511 |
| 79 | PRKCE | 0.68378254 |
| 80 | RET | 0.67734469 |
| 81 | LIMK1 | 0.67215534 |
| 82 | OXSR1 | 0.66859583 |
| 83 | PDK3 | 0.66590925 |
| 84 | PDK4 | 0.66590925 |
| 85 | CSNK1G3 | 0.63681352 |
| 86 | CDK18 | 0.63022885 |
| 87 | ERBB2 | 0.62206073 |
| 88 | CDK15 | 0.61606874 |
| 89 | DAPK3 | 0.60623237 |
| 90 | CDK14 | 0.58788744 |
| 91 | INSRR | 0.57790561 |
| 92 | CAMK4 | 0.57340961 |
| 93 | CSNK1G2 | 0.56627324 |
| 94 | FGR | 0.56156559 |
| 95 | PDK1 | 0.55319791 |
| 96 | PRKACA | 0.54124571 |
| 97 | DMPK | 0.53910892 |
| 98 | PRKAA1 | 0.53713419 |
| 99 | BRSK1 | 0.53325128 |
| 100 | PDPK1 | 0.53192274 |
| 101 | CDK11A | 0.52493794 |
| 102 | NME1 | 0.51168090 |
| 103 | CAMKK2 | 0.50476990 |
| 104 | AKT3 | 0.48365726 |
| 105 | PRKCZ | 0.48258313 |
| 106 | OBSCN | 0.47291295 |
| 107 | NEK6 | 0.47022544 |
| 108 | CAMK2G | 0.46907953 |
| 109 | CAMK1D | 0.46351314 |
| 110 | RPS6KA3 | 0.46041236 |
| 111 | PRKG1 | 0.45668154 |
| 112 | ROCK1 | 0.45234024 |
| 113 | CSNK1A1L | 0.45202801 |
| 114 | CSNK1E | 0.45099914 |
| 115 | CSNK1G1 | 0.45042381 |
| 116 | ROCK2 | 0.44996459 |
| 117 | STK39 | 0.44978825 |
| 118 | IRAK2 | 0.44902337 |
| 119 | MAPK12 | 0.44897324 |
| 120 | TNK2 | 0.43991067 |
| 121 | WNK4 | 0.43826286 |
| 122 | RPS6KA2 | 0.41905901 |
| 123 | RAF1 | 0.41552024 |
| 124 | MAP3K7 | 0.41333709 |
| 125 | FYN | 0.40729258 |
| 126 | MAP3K11 | 0.40723994 |
| 127 | ADRBK2 | 0.40533323 |
| 128 | MAP3K1 | 0.40436994 |
| 129 | MAPK10 | 0.39951601 |
| 130 | FER | 0.39788658 |
| 131 | DYRK3 | 0.37220674 |
| 132 | ADRBK1 | 0.34945421 |
| 133 | RPS6KA6 | 0.34259559 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.61442826 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.89434472 |
| 3 | Circadian entrainment_Homo sapiens_hsa04713 | 2.63458867 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.63205319 |
| 5 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.53846280 |
| 6 | Olfactory transduction_Homo sapiens_hsa04740 | 2.52485759 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.52023767 |
| 8 | Long-term potentiation_Homo sapiens_hsa04720 | 2.48174782 |
| 9 | Morphine addiction_Homo sapiens_hsa05032 | 2.46851116 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.31842061 |
| 11 | Salivary secretion_Homo sapiens_hsa04970 | 2.06194661 |
| 12 | Insulin secretion_Homo sapiens_hsa04911 | 2.04305629 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.03763578 |
| 14 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.93077716 |
| 15 | Taste transduction_Homo sapiens_hsa04742 | 1.92053043 |
| 16 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.88971668 |
| 17 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.85683482 |
| 18 | Renin secretion_Homo sapiens_hsa04924 | 1.78169246 |
| 19 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.77975047 |
| 20 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.77590727 |
| 21 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.76673921 |
| 22 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.72031519 |
| 23 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.65689663 |
| 24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.63772276 |
| 25 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.61703635 |
| 26 | Cocaine addiction_Homo sapiens_hsa05030 | 1.61292155 |
| 27 | Long-term depression_Homo sapiens_hsa04730 | 1.60973992 |
| 28 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.39213735 |
| 29 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.37700977 |
| 30 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.36755474 |
| 31 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.36157993 |
| 32 | Axon guidance_Homo sapiens_hsa04360 | 1.34450123 |
| 33 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.30735899 |
| 34 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.28040530 |
| 35 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.26652599 |
| 36 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.24374541 |
| 37 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.24184997 |
| 38 | Gap junction_Homo sapiens_hsa04540 | 1.23658347 |
| 39 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.23313671 |
| 40 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.20538674 |
| 41 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.17260359 |
| 42 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.14141963 |
| 43 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.13699335 |
| 44 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.11396772 |
| 45 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.04540972 |
| 46 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.03742103 |
| 47 | Melanogenesis_Homo sapiens_hsa04916 | 1.03289028 |
| 48 | Glioma_Homo sapiens_hsa05214 | 1.00651082 |
| 49 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.99807538 |
| 50 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.96646010 |
| 51 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.95204091 |
| 52 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.94664047 |
| 53 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.94472450 |
| 54 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.89582960 |
| 55 | Phototransduction_Homo sapiens_hsa04744 | 0.87715121 |
| 56 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.86232405 |
| 57 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.86076049 |
| 58 | Sulfur relay system_Homo sapiens_hsa04122 | 0.85129643 |
| 59 | Bile secretion_Homo sapiens_hsa04976 | 0.84970405 |
| 60 | Alzheimers disease_Homo sapiens_hsa05010 | 0.83604770 |
| 61 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.82721436 |
| 62 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.82508690 |
| 63 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.81574877 |
| 64 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.81072336 |
| 65 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.79922269 |
| 66 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.76971271 |
| 67 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.76627721 |
| 68 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.74500856 |
| 69 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.74207142 |
| 70 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.72046433 |
| 71 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.70759922 |
| 72 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.70368599 |
| 73 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.69684879 |
| 74 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.69498399 |
| 75 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.68886366 |
| 76 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.68469283 |
| 77 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.66760883 |
| 78 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.66208781 |
| 79 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.65819426 |
| 80 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.64820820 |
| 81 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.64028899 |
| 82 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.63501106 |
| 83 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.62962103 |
| 84 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.62696070 |
| 85 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.62633570 |
| 86 | Parkinsons disease_Homo sapiens_hsa05012 | 0.61160242 |
| 87 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.60473678 |
| 88 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59912230 |
| 89 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.58937982 |
| 90 | Circadian rhythm_Homo sapiens_hsa04710 | 0.58564887 |
| 91 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.54534134 |
| 92 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.54026061 |
| 93 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.53927726 |
| 94 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.53675277 |
| 95 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.53401680 |
| 96 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.52982456 |
| 97 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.52816412 |
| 98 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.52225193 |
| 99 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.51542975 |
| 100 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.51282917 |
| 101 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.51242510 |
| 102 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.51147261 |
| 103 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.48688764 |
| 104 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.48402674 |
| 105 | Tight junction_Homo sapiens_hsa04530 | 0.47160157 |
| 106 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.46601367 |
| 107 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.46253141 |
| 108 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.46071940 |
| 109 | Peroxisome_Homo sapiens_hsa04146 | 0.45392296 |
| 110 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.45350848 |
| 111 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.44539854 |
| 112 | Huntingtons disease_Homo sapiens_hsa05016 | 0.44502874 |
| 113 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.44409746 |
| 114 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.44359357 |
| 115 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.43810731 |
| 116 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.42296692 |
| 117 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.42076651 |
| 118 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.40771430 |
| 119 | Endometrial cancer_Homo sapiens_hsa05213 | 0.38513688 |
| 120 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.38495835 |
| 121 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.37813933 |
| 122 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.37799548 |
| 123 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.36645812 |
| 124 | Alcoholism_Homo sapiens_hsa05034 | 0.36606447 |
| 125 | Endocytosis_Homo sapiens_hsa04144 | 0.34391950 |
| 126 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.30196998 |
| 127 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.28448515 |
| 128 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.28195907 |
| 129 | Prion diseases_Homo sapiens_hsa05020 | 0.26784376 |
| 130 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.26341901 |
| 131 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.26150618 |
| 132 | Melanoma_Homo sapiens_hsa05218 | 0.25310693 |

