TMEM91

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.41012139
2presynaptic membrane assembly (GO:0097105)5.10199087
3leukocyte migration involved in inflammatory response (GO:0002523)4.99039162
4postsynaptic membrane organization (GO:0001941)4.87885553
5thrombin receptor signaling pathway (GO:0070493)4.67309706
6positive regulation of mast cell activation (GO:0033005)4.53052258
7presynaptic membrane organization (GO:0097090)4.51718816
8neutrophil activation (GO:0042119)4.50241718
9neuron cell-cell adhesion (GO:0007158)4.38945105
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.20167179
11regulation of platelet aggregation (GO:0090330)4.00172532
12granulocyte activation (GO:0036230)3.95174772
13negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92333801
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.88236817
15neuronal action potential propagation (GO:0019227)3.86279537
16regulation of platelet activation (GO:0010543)3.83319992
17protein neddylation (GO:0045116)3.81355512
18positive regulation of gamma-delta T cell activation (GO:0046645)3.73737844
19regulation of mast cell activation (GO:0033003)3.71763374
20purinergic nucleotide receptor signaling pathway (GO:0035590)3.69168383
21positive regulation of mast cell degranulation (GO:0043306)3.60293809
22positive regulation of mast cell activation involved in immune response (GO:0033008)3.60293809
23respiratory chain complex IV assembly (GO:0008535)3.59408363
24regulation of mast cell degranulation (GO:0043304)3.56154064
25vocalization behavior (GO:0071625)3.54094273
26negative regulation of cell killing (GO:0031342)3.52822664
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52822664
28negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.48109969
29leukocyte degranulation (GO:0043299)3.47112828
30regulation of mast cell activation involved in immune response (GO:0033006)3.44753626
31cytochrome complex assembly (GO:0017004)3.40985340
32microglial cell activation (GO:0001774)3.37646782
33protein complex biogenesis (GO:0070271)3.37240451
34lipoxygenase pathway (GO:0019372)3.35840194
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.33127809
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.29919071
37protein localization to cilium (GO:0061512)3.29872165
38positive regulation of B cell differentiation (GO:0045579)3.26140537
39protein localization to synapse (GO:0035418)3.25528633
40righting reflex (GO:0060013)3.24248424
41regulation of MHC class II biosynthetic process (GO:0045346)3.24040576
42regulation of B cell receptor signaling pathway (GO:0050855)3.21123869
43immunoglobulin mediated immune response (GO:0016064)3.20435039
44cellular extravasation (GO:0045123)3.19001264
45regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17816802
46myeloid cell activation involved in immune response (GO:0002275)3.17573134
47startle response (GO:0001964)3.14855363
48detection of other organism (GO:0098543)3.11714439
49detection of bacterium (GO:0016045)3.10838208
50positive regulation of synapse assembly (GO:0051965)3.10834964
51antigen processing and presentation of endogenous antigen (GO:0019883)3.10374658
52dopamine transport (GO:0015872)3.09071849
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08649843
54negative regulation of thymocyte apoptotic process (GO:0070244)3.08244148
55superoxide anion generation (GO:0042554)3.04778427
56positive regulation by symbiont of host defense response (GO:0052509)3.04136367
57modulation by symbiont of host defense response (GO:0052031)3.04136367
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.04136367
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.04136367
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.04136367
61modulation by symbiont of host immune response (GO:0052553)3.04136367
62purinergic receptor signaling pathway (GO:0035587)3.04069483
63negative regulation of T-helper cell differentiation (GO:0045623)3.04021688
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04021688
65long-chain fatty acid biosynthetic process (GO:0042759)3.02976765
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01277923
67response to peptidoglycan (GO:0032494)3.00739498
68glutamate receptor signaling pathway (GO:0007215)3.00673814
69G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.98940875
70gamma-aminobutyric acid signaling pathway (GO:0007214)2.97864816
71neuron-neuron synaptic transmission (GO:0007270)2.97699644
72Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97656941
73DNA deamination (GO:0045006)2.97223418
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.96847643
75mitochondrial respiratory chain complex assembly (GO:0033108)2.96633761
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95503020
77mitochondrial respiratory chain complex I assembly (GO:0032981)2.95503020
78NADH dehydrogenase complex assembly (GO:0010257)2.95503020
79mannosylation (GO:0097502)2.90550655
80short-term memory (GO:0007614)2.90018827
81positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.89090353
82regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88564297
83developmental pigmentation (GO:0048066)2.87263877
84regulation of gamma-delta T cell activation (GO:0046643)2.86807246
85negative regulation of heart rate (GO:0010459)2.86424049
86antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83560341
87synaptic transmission, glutamatergic (GO:0035249)2.82807313
88mast cell activation (GO:0045576)2.80644002
89synaptic transmission, dopaminergic (GO:0001963)2.79484210
90respiratory electron transport chain (GO:0022904)2.78787397
91adenosine receptor signaling pathway (GO:0001973)2.78426863
92phosphatidylinositol acyl-chain remodeling (GO:0036149)2.74175716
93electron transport chain (GO:0022900)2.72865398
94regulation of synaptic transmission, GABAergic (GO:0032228)2.72100885
95regulation of regulatory T cell differentiation (GO:0045589)2.71726889
96GTP biosynthetic process (GO:0006183)2.71439148
97neurotransmitter-gated ion channel clustering (GO:0072578)2.70804767
98regulation of pigment cell differentiation (GO:0050932)2.70611720
99response to histamine (GO:0034776)2.70399621
100megakaryocyte development (GO:0035855)2.70011706
101B cell mediated immunity (GO:0019724)2.68806178
102negative regulation of lymphocyte mediated immunity (GO:0002707)2.67942002
103serotonin receptor signaling pathway (GO:0007210)2.66805896
104regulation of thymocyte apoptotic process (GO:0070243)2.66499742
105regulation of leukocyte degranulation (GO:0043300)2.66115173
106autophagic vacuole fusion (GO:0000046)2.65945990
107angiogenesis involved in wound healing (GO:0060055)2.65415585
108positive regulation of neurotransmitter transport (GO:0051590)2.65188570
109regulation of memory T cell differentiation (GO:0043380)2.64060743
110regulation of glutamate receptor signaling pathway (GO:1900449)2.63571742
111positive regulation of granulocyte differentiation (GO:0030854)2.62958341
112negative regulation of interleukin-12 production (GO:0032695)2.62915217
113B cell receptor signaling pathway (GO:0050853)2.62829817
114regulation of gamma-delta T cell differentiation (GO:0045586)2.61051017
115regulation of timing of cell differentiation (GO:0048505)2.60679868
116positive regulation of cAMP-mediated signaling (GO:0043950)2.60441224
117cellular biogenic amine catabolic process (GO:0042402)2.60299358
118amine catabolic process (GO:0009310)2.60299358
119pyrimidine nucleoside catabolic process (GO:0046135)2.60166842
120neurotransmitter uptake (GO:0001504)2.59774417
121regulation of respiratory system process (GO:0044065)2.59074772
122activated T cell proliferation (GO:0050798)2.58855103
123synaptic vesicle exocytosis (GO:0016079)2.58181802
124negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.57357605
125chaperone-mediated protein transport (GO:0072321)2.57309289
126negative regulation of execution phase of apoptosis (GO:1900118)2.57145088
127regulation of B cell differentiation (GO:0045577)2.57130378
128positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.56492596
129transmission of nerve impulse (GO:0019226)2.56421267
130negative regulation of T cell apoptotic process (GO:0070233)2.55956874
131axon ensheathment in central nervous system (GO:0032291)2.55938278
132central nervous system myelination (GO:0022010)2.55938278
133response to host immune response (GO:0052572)2.55762670
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55762670
135positive regulation of neurotransmitter secretion (GO:0001956)2.55022096
136platelet aggregation (GO:0070527)2.54898948
137actin nucleation (GO:0045010)2.54689661
138positive regulation of membrane potential (GO:0045838)2.54090553
139regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53797657
140mesenchymal cell differentiation involved in kidney development (GO:0072161)2.53570541
141mesenchymal cell differentiation involved in renal system development (GO:2001012)2.53570541
142positive regulation of amino acid transport (GO:0051957)2.52554819
143negative regulation of neurotransmitter transport (GO:0051589)2.52271627
144regulation of protein kinase A signaling (GO:0010738)2.51956981
145macrophage activation involved in immune response (GO:0002281)2.51656195
146triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.50556403
147leukocyte aggregation (GO:0070486)2.50537884
148detection of external biotic stimulus (GO:0098581)2.49943858
149mast cell activation involved in immune response (GO:0002279)2.48847017
150mast cell degranulation (GO:0043303)2.48847017
151regulation of glutamate secretion (GO:0014048)2.48260793
152positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.47776497
153macrophage activation (GO:0042116)2.47037026
154positive regulation of uterine smooth muscle contraction (GO:0070474)2.47036111
155energy coupled proton transport, down electrochemical gradient (GO:0015985)2.46541358
156ATP synthesis coupled proton transport (GO:0015986)2.46541358
157negative regulation of alpha-beta T cell activation (GO:0046636)2.46163383
158monoamine transport (GO:0015844)2.45763187
159positive regulation of action potential (GO:0045760)2.45484459
160long-term memory (GO:0007616)2.45479862
161negative regulation of platelet activation (GO:0010544)2.44240346
162regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.44202541
163regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.44202541
164blood coagulation, intrinsic pathway (GO:0007597)2.44175280
165mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.44064408
166GPI anchor biosynthetic process (GO:0006506)2.42775821
167positive regulation of T cell mediated cytotoxicity (GO:0001916)2.42573176
168regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42515836
169cardiolipin metabolic process (GO:0032048)2.41980776
170G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41539081
171regulation of synapse assembly (GO:0051963)2.41441055
172negative regulation of response to food (GO:0032096)2.41018820
173negative regulation of appetite (GO:0032099)2.41018820
174regulation of regulated secretory pathway (GO:1903305)2.40848879
175adult walking behavior (GO:0007628)2.40776086
176regulation of inositol phosphate biosynthetic process (GO:0010919)2.40586253
177cranial nerve structural organization (GO:0021604)2.40022594
178regulation of natural killer cell mediated immunity (GO:0002715)2.39538358
179regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.39538358
180regulation of excitatory postsynaptic membrane potential (GO:0060079)2.38877369
181photoreceptor cell maintenance (GO:0045494)2.38120472
182nonmotile primary cilium assembly (GO:0035058)2.37849426
183positive regulation of type 2 immune response (GO:0002830)2.37653172
184facial nerve structural organization (GO:0021612)2.35088368
185mechanosensory behavior (GO:0007638)2.33972845
186regulation of respiratory gaseous exchange (GO:0043576)2.33796086
187keratinocyte development (GO:0003334)2.32735961
188cAMP catabolic process (GO:0006198)2.31057318
189sympathetic nervous system development (GO:0048485)2.29675013
190opioid receptor signaling pathway (GO:0038003)2.29299643
191protein heterotetramerization (GO:0051290)2.28691000
192regulation of development, heterochronic (GO:0040034)2.28614651
193cyclic nucleotide catabolic process (GO:0009214)2.28260771
194synapse assembly (GO:0007416)2.28232361
195regulation of catecholamine metabolic process (GO:0042069)2.27871594
196regulation of dopamine metabolic process (GO:0042053)2.27871594
197rhodopsin mediated signaling pathway (GO:0016056)2.27495427
198regulation of synaptic vesicle exocytosis (GO:2000300)2.27290682
199intraciliary transport (GO:0042073)2.27220744
200cilium movement (GO:0003341)2.27144654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96651289
2GBX2_23144817_ChIP-Seq_PC3_Human4.03859094
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.74712795
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.42632774
5SCL_19346495_ChIP-Seq_HPC-7_Human3.30866175
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.09775083
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.96423415
8SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.94322357
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91597401
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.85562999
11TAF15_26573619_Chip-Seq_HEK293_Human2.84204461
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78333589
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65560684
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51097839
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48712186
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45896482
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.40600623
18LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.36876950
19* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.36225591
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29550517
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21072393
22IGF1R_20145208_ChIP-Seq_DFB_Human2.20749482
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20368249
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13957909
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.13878889
26GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.11983619
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11912588
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11272676
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10536790
30GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.07476967
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07239708
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.05303548
33CBX2_27304074_Chip-Seq_ESCs_Mouse2.03020375
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98754652
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96032141
36SPI1_23127762_ChIP-Seq_K562_Human1.95946461
37GATA1_19941826_ChIP-Seq_K562_Human1.92113424
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91176276
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91176276
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.89047408
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87536295
42* GATA1_19941827_ChIP-Seq_MEL_Mouse1.86390060
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83193895
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81856034
45VDR_22108803_ChIP-Seq_LS180_Human1.81699658
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76029503
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75371542
48RNF2_27304074_Chip-Seq_NSC_Mouse1.74585116
49RUNX_20019798_ChIP-Seq_JUKART_Human1.73739145
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.71961383
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71843192
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71296481
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.70956912
54REST_21632747_ChIP-Seq_MESCs_Mouse1.70708089
55P300_19829295_ChIP-Seq_ESCs_Human1.69687734
56* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66192025
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62874271
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61667267
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61592274
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61192212
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59753942
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59262011
63FUS_26573619_Chip-Seq_HEK293_Human1.58866513
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58742605
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57611889
66ER_23166858_ChIP-Seq_MCF-7_Human1.57460980
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56351207
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.55468075
69IRF1_19129219_ChIP-ChIP_H3396_Human1.54260857
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52436175
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.49570996
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48695234
73P53_22387025_ChIP-Seq_ESCs_Mouse1.48410433
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48231974
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47458869
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.47325991
77GATA2_19941826_ChIP-Seq_K562_Human1.46768060
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.44459200
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.44393961
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44327265
81* SPI1_23547873_ChIP-Seq_NB4_Human1.44157022
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.41917381
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40942911
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40741683
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40597499
86BCL6_27268052_Chip-Seq_Bcells_Human1.40252576
87P300_18555785_Chip-Seq_ESCs_Mouse1.40125571
88SMAD4_21799915_ChIP-Seq_A2780_Human1.40121880
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37859917
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37147129
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36830702
92RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36678819
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35136877
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34850718
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.34646783
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.32927446
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.31765770
98VDR_24763502_ChIP-Seq_THP-1_Human1.31451592
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31146848
100GATA3_26560356_Chip-Seq_TH2_Human1.30512254
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29334871
102GATA3_27048872_Chip-Seq_THYMUS_Human1.28990377
103AR_21572438_ChIP-Seq_LNCaP_Human1.28404733
104GATA3_21878914_ChIP-Seq_MCF-7_Human1.28010808
105SPI1_20517297_ChIP-Seq_HL60_Human1.27653717
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.26522660
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.24094891
108UTX_26944678_Chip-Seq_JUKART_Human1.23782116
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.22820459
110EWS_26573619_Chip-Seq_HEK293_Human1.22722515
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.22489965
112NANOG_20526341_ChIP-Seq_ESCs_Human1.21493240
113KLF4_18555785_Chip-Seq_ESCs_Mouse1.21384143
114MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21235003
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19633529
116VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19464164
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18346550
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18223208
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18215199
120ZFX_18555785_Chip-Seq_ESCs_Mouse1.18195054
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18055104
122STAT1_20625510_ChIP-Seq_HELA_Human1.18012841
123PU1_27457419_Chip-Seq_LIVER_Mouse1.17931089
124BCOR_27268052_Chip-Seq_Bcells_Human1.17465777
125MYB_26560356_Chip-Seq_TH2_Human1.17344602
126REST_18959480_ChIP-ChIP_MESCs_Mouse1.17180761
127EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17072339
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16955384
129SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16427424
130CTCF_18555785_Chip-Seq_ESCs_Mouse1.13947420
131PIAS1_25552417_ChIP-Seq_VCAP_Human1.12973942
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12116458
133BP1_19119308_ChIP-ChIP_Hs578T_Human1.11653139
134VDR_24787735_ChIP-Seq_THP-1_Human1.10316217
135ELF1_20517297_ChIP-Seq_JURKAT_Human1.09602548
136ZNF274_21170338_ChIP-Seq_K562_Hela1.08319254
137ESRRB_18555785_Chip-Seq_ESCs_Mouse1.07819895
138P300_27268052_Chip-Seq_Bcells_Human1.07816103
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07470867
140TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07281514
141KDM2B_26808549_Chip-Seq_REH_Human1.07183069
142ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06767056
143SMAD_19615063_ChIP-ChIP_OVARY_Human1.06743846
144AR_25329375_ChIP-Seq_VCAP_Human1.06581143
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05807065
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05709391
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05414857
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05382788
149GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04540923
150RUNX2_22187159_ChIP-Seq_PCA_Human1.04423365
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04068276
152FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03797192
153STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03116499
154* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02818776
155MAF_26560356_Chip-Seq_TH1_Human1.02307960
156YY1_22570637_ChIP-Seq_MALME-3M_Human1.02030490
157PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01739428
158DROSHA_22980978_ChIP-Seq_HELA_Human1.01667916
159GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00883853
160HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99928725
161FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99876385
162E2F1_20622854_ChIP-Seq_HELA_Human0.99734346
163CRX_20693478_ChIP-Seq_RETINA_Mouse0.99112207
164JUN_21703547_ChIP-Seq_K562_Human0.98218530
165LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98061202
166OCT4_20526341_ChIP-Seq_ESCs_Human0.97450648
167TAF2_19829295_ChIP-Seq_ESCs_Human0.97346463
168SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97325529
169TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96790866
170SMRT_27268052_Chip-Seq_Bcells_Human0.94474754
171FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93698673
172PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92993223
173GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90985604
174GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89326575
175RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88581839
176P68_20966046_ChIP-Seq_HELA_Human0.88438857
177CEBPB_22108803_ChIP-Seq_LS180_Human0.88345734
178CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87246129
179ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86307097
180KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86231323
181PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85966677
182CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84351717
183ERA_21632823_ChIP-Seq_H3396_Human0.83284764
184BCAT_22108803_ChIP-Seq_LS180_Human0.82612756
185TP53_22573176_ChIP-Seq_HFKS_Human0.82296193
186MYB_26560356_Chip-Seq_TH1_Human0.82239134
187CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82173700
188CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82099237
189EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81850052
190TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81607124
191SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81241405
192STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.79969993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.56004445
2MP0003880_abnormal_central_pattern4.47735961
3MP0001188_hyperpigmentation3.99183213
4MP0006292_abnormal_olfactory_placode3.08344387
5MP0001986_abnormal_taste_sensitivity3.07330095
6MP0005409_darkened_coat_color2.89336023
7MP0001835_abnormal_antigen_presentation2.87924694
8MP0003303_peritoneal_inflammation2.77297972
9MP0003136_yellow_coat_color2.71577269
10MP0008004_abnormal_stomach_pH2.67846296
11MP0003436_decreased_susceptibility_to2.66185373
12MP0009379_abnormal_foot_pigmentation2.59493345
13MP0005423_abnormal_somatic_nervous2.53573785
14MP0009745_abnormal_behavioral_response2.51681223
15MP0006276_abnormal_autonomic_nervous2.46493573
16MP0009046_muscle_twitch2.44328621
17MP0000465_gastrointestinal_hemorrhage2.40325405
18MP0001968_abnormal_touch/_nociception2.39785267
19MP0003635_abnormal_synaptic_transmissio2.33261526
20MP0002272_abnormal_nervous_system2.24918312
21MP0001486_abnormal_startle_reflex2.20859279
22MP0002064_seizures2.18559249
23MP0001800_abnormal_humoral_immune2.13640010
24MP0002735_abnormal_chemical_nociception2.13275866
25MP0005000_abnormal_immune_tolerance2.11676340
26MP0002653_abnormal_ependyma_morphology2.10241362
27MP0002876_abnormal_thyroid_physiology2.08735544
28MP0004859_abnormal_synaptic_plasticity2.08169536
29MP0002572_abnormal_emotion/affect_behav2.08102370
30MP0004142_abnormal_muscle_tone2.06541917
31MP0001529_abnormal_vocalization2.05845942
32MP0002419_abnormal_innate_immunity2.05348711
33MP0002723_abnormal_immune_serum1.99361462
34MP0002736_abnormal_nociception_after1.97635919
35MP0005025_abnormal_response_to1.94580045
36MP0001905_abnormal_dopamine_level1.93897738
37MP0003787_abnormal_imprinting1.91012831
38MP0005645_abnormal_hypothalamus_physiol1.90405146
39MP0005387_immune_system_phenotype1.90331139
40MP0001790_abnormal_immune_system1.90331139
41MP0000685_abnormal_immune_system1.89450721
42MP0005646_abnormal_pituitary_gland1.89444665
43MP0009764_decreased_sensitivity_to1.89113925
44MP0001984_abnormal_olfaction1.88720121
45MP0002452_abnormal_antigen_presenting1.83339632
46MP0002102_abnormal_ear_morphology1.82870733
47MP0001501_abnormal_sleep_pattern1.82768072
48MP0002420_abnormal_adaptive_immunity1.80736765
49MP0002063_abnormal_learning/memory/cond1.79650964
50MP0004381_abnormal_hair_follicle1.79391304
51MP0005174_abnormal_tail_pigmentation1.79018092
52MP0001819_abnormal_immune_cell1.77401540
53MP0005083_abnormal_biliary_tract1.74260167
54MP0000015_abnormal_ear_pigmentation1.70706766
55MP0002734_abnormal_mechanical_nocicepti1.68533305
56MP0005397_hematopoietic_system_phenotyp1.67369355
57MP0001545_abnormal_hematopoietic_system1.67369355
58MP0002067_abnormal_sensory_capabilities1.67036491
59MP0001970_abnormal_pain_threshold1.61459592
60MP0005171_absent_coat_pigmentation1.59688732
61MP0002557_abnormal_social/conspecific_i1.59050234
62MP0009278_abnormal_bone_marrow1.58931057
63MP0001533_abnormal_skeleton_physiology1.57402059
64MP0005551_abnormal_eye_electrophysiolog1.57145818
65MP0010155_abnormal_intestine_physiology1.55350818
66MP0002822_catalepsy1.53204624
67MP0000230_abnormal_systemic_arterial1.52201669
68MP0004130_abnormal_muscle_cell1.51106764
69MP0002398_abnormal_bone_marrow1.48026071
70MP0003122_maternal_imprinting1.45092472
71MP0004742_abnormal_vestibular_system1.43224318
72MP0005379_endocrine/exocrine_gland_phen1.42815962
73MP0002638_abnormal_pupillary_reflex1.40871233
74MP0000343_altered_response_to1.39333933
75MP0003866_abnormal_defecation1.38171521
76MP0001663_abnormal_digestive_system1.38116898
77MP0003724_increased_susceptibility_to1.37407691
78MP0005167_abnormal_blood-brain_barrier1.37311488
79MP0001440_abnormal_grooming_behavior1.36549317
80MP0000716_abnormal_immune_system1.35779173
81MP0002733_abnormal_thermal_nociception1.34684952
82MP0001845_abnormal_inflammatory_respons1.32050187
83MP0000689_abnormal_spleen_morphology1.31718682
84MP0003011_delayed_dark_adaptation1.31343696
85MP0004270_analgesia1.30620685
86MP0008260_abnormal_autophagy1.29314006
87MP0000566_synostosis1.29266507
88MP0002405_respiratory_system_inflammati1.28071845
89MP0003638_abnormal_response/metabolism_1.26781120
90MP0003828_pulmonary_edema1.26450439
91MP0002184_abnormal_innervation1.25730860
92MP0006082_CNS_inflammation1.22374710
93MP0003879_abnormal_hair_cell1.21832468
94MP0001502_abnormal_circadian_rhythm1.21391579
95MP0000372_irregular_coat_pigmentation1.20868853
96MP0000026_abnormal_inner_ear1.20299164
97MP0001963_abnormal_hearing_physiology1.19281956
98MP0004510_myositis1.18681908
99MP0002429_abnormal_blood_cell1.17942464
100MP0002163_abnormal_gland_morphology1.17202666
101MP0006072_abnormal_retinal_apoptosis1.15384613
102MP0003172_abnormal_lysosome_physiology1.14677572
103MP0000631_abnormal_neuroendocrine_gland1.13749053
104MP0005377_hearing/vestibular/ear_phenot1.13636781
105MP0003878_abnormal_ear_physiology1.13636781
106MP0003938_abnormal_ear_development1.13143904
107MP0002722_abnormal_immune_system1.11775651
108MP0008995_early_reproductive_senescence1.11057126
109MP0002277_abnormal_respiratory_mucosa1.08078490
110MP0005075_abnormal_melanosome_morpholog1.07208720
111MP0008569_lethality_at_weaning1.05737019
112MP0001485_abnormal_pinna_reflex1.05411594
113MP0004947_skin_inflammation1.05318840
114MP0002095_abnormal_skin_pigmentation1.03091483
115MP0004924_abnormal_behavior1.02813447
116MP0005386_behavior/neurological_phenoty1.02813447
117MP0005253_abnormal_eye_physiology1.00223176
118MP0002138_abnormal_hepatobiliary_system1.00086959
119MP0001851_eye_inflammation0.98523346
120MP0008469_abnormal_protein_level0.98093452
121MP0009765_abnormal_xenobiotic_induced0.98065258
122MP0000778_abnormal_nervous_system0.96492725
123MP0010386_abnormal_urinary_bladder0.95568917
124MP0002882_abnormal_neuron_morphology0.95218294
125MP0005058_abnormal_lysosome_morphology0.94955919
126MP0002752_abnormal_somatic_nervous0.94510467
127MP0005535_abnormal_body_temperature0.94367337
128MP0002751_abnormal_autonomic_nervous0.92795786
129MP0008877_abnormal_DNA_methylation0.91825750
130MP0000681_abnormal_thyroid_gland0.91371401
131MP0003300_gastrointestinal_ulcer0.90134404
132MP0003075_altered_response_to0.89150912
133MP0005394_taste/olfaction_phenotype0.87837569
134MP0005499_abnormal_olfactory_system0.87837569
135MP0000049_abnormal_middle_ear0.87700650
136MP0009333_abnormal_splenocyte_physiolog0.87416530
137MP0009763_increased_sensitivity_to0.85849556
138MP0002066_abnormal_motor_capabilities/c0.85334774
139MP0002229_neurodegeneration0.84656640
140MP0008789_abnormal_olfactory_epithelium0.80842568
141MP0001664_abnormal_digestion0.80349698
142MP0008875_abnormal_xenobiotic_pharmacok0.76236350
143MP0000249_abnormal_blood_vessel0.76032664
144MP0002148_abnormal_hypersensitivity_rea0.74860112
145MP0005310_abnormal_salivary_gland0.74653797
146MP0008874_decreased_physiological_sensi0.74300988
147MP0000955_abnormal_spinal_cord0.73980424
148MP0009642_abnormal_blood_homeostasis0.73754852
149MP0005381_digestive/alimentary_phenotyp0.71897205
150MP0004883_abnormal_blood_vessel0.71444647
151MP0002928_abnormal_bile_duct0.70879981
152MP0000703_abnormal_thymus_morphology0.69239497
153MP0002177_abnormal_outer_ear0.69043264
154MP0004885_abnormal_endolymph0.69022373
155MP0001765_abnormal_ion_homeostasis0.68857392
156MP0004145_abnormal_muscle_electrophysio0.68425280
157MP0005671_abnormal_response_to0.67609275
158MP0003806_abnormal_nucleotide_metabolis0.67121033
159MP0003763_abnormal_thymus_physiology0.66508195
160MP0002693_abnormal_pancreas_physiology0.66454195
161MP0000920_abnormal_myelination0.65729715
162MP0005084_abnormal_gallbladder_morpholo0.63588454
163MP0002938_white_spotting0.62596382
164MP0003183_abnormal_peptide_metabolism0.62417539
165MP0008872_abnormal_physiological_respon0.59412530
166MP0005410_abnormal_fertilization0.58359710
167MP0002160_abnormal_reproductive_system0.58319833
168MP0003121_genomic_imprinting0.58255648
169MP0009785_altered_susceptibility_to0.57991376
170MP0002132_abnormal_respiratory_system0.56472413

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.88962005
2Petechiae (HP:0000967)6.28150638
3Menorrhagia (HP:0000132)5.76148713
4Purpura (HP:0000979)5.72429351
5Abnormal platelet volume (HP:0011876)5.44667822
6Epistaxis (HP:0000421)5.38769039
7Increased mean platelet volume (HP:0011877)5.27931486
8Stomatitis (HP:0010280)4.69045696
9Gingival bleeding (HP:0000225)4.52171708
10Focal motor seizures (HP:0011153)4.38339029
11Spontaneous hematomas (HP:0007420)3.75518709
12Elevated erythrocyte sedimentation rate (HP:0003565)3.74900650
13Hypothermia (HP:0002045)3.51579235
14Abnormality of the heme biosynthetic pathway (HP:0010472)3.51112119
15Abnormality of macrophages (HP:0004311)3.46719902
16Febrile seizures (HP:0002373)3.46621648
17Absent/shortened dynein arms (HP:0200106)3.44142994
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.44142994
19Acute necrotizing encephalopathy (HP:0006965)3.43406352
20Abnormal ciliary motility (HP:0012262)3.39615151
21Myositis (HP:0100614)3.38548083
22Mitochondrial inheritance (HP:0001427)3.34740256
23Recurrent abscess formation (HP:0002722)3.26469686
24Hyperlipoproteinemia (HP:0010980)3.26393157
25Recurrent bacterial skin infections (HP:0005406)3.22163567
26Eczematoid dermatitis (HP:0000976)3.21198596
27Type I transferrin isoform profile (HP:0003642)3.18416400
28Encephalitis (HP:0002383)3.06955900
29Abnormal respiratory motile cilium morphology (HP:0005938)3.06417207
30Abnormal respiratory epithelium morphology (HP:0012253)3.06417207
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.05001863
32Abnormal platelet function (HP:0011869)3.02920411
33Impaired platelet aggregation (HP:0003540)3.02920411
34Abnormal mitochondria in muscle tissue (HP:0008316)3.00873810
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.99596705
36Retrobulbar optic neuritis (HP:0100654)2.98840519
37Optic neuritis (HP:0100653)2.98840519
38Optic disc pallor (HP:0000543)2.98722124
39Orchitis (HP:0100796)2.94012445
40Abnormal hair whorl (HP:0010721)2.93946006
41Progressive macrocephaly (HP:0004481)2.92767868
42Abnormal respiratory motile cilium physiology (HP:0012261)2.91906737
43Hepatocellular necrosis (HP:0001404)2.85908813
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.81261274
45Decreased central vision (HP:0007663)2.79824829
46Attenuation of retinal blood vessels (HP:0007843)2.78800864
47Medial flaring of the eyebrow (HP:0010747)2.74713105
48Episodic fever (HP:0001954)2.74383673
49Renal Fanconi syndrome (HP:0001994)2.72524143
50Increased hepatocellular lipid droplets (HP:0006565)2.71840354
51Increased IgM level (HP:0003496)2.70790303
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68042603
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.65128081
54Increased CSF lactate (HP:0002490)2.65018689
55Reduced antithrombin III activity (HP:0001976)2.63696986
563-Methylglutaconic aciduria (HP:0003535)2.63286391
57Myokymia (HP:0002411)2.62259296
58Atonic seizures (HP:0010819)2.61408045
59Epileptic encephalopathy (HP:0200134)2.59531331
60Broad-based gait (HP:0002136)2.59294098
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57169718
62Recurrent fungal infections (HP:0002841)2.55939257
63Thyroid-stimulating hormone excess (HP:0002925)2.54507648
64Gait imbalance (HP:0002141)2.54073852
65Congenital primary aphakia (HP:0007707)2.45260363
66True hermaphroditism (HP:0010459)2.44664304
67Congenital stationary night blindness (HP:0007642)2.44323433
68Abnormality of secondary sexual hair (HP:0009888)2.44136725
69Abnormality of the axillary hair (HP:0100134)2.44136725
70Poikilocytosis (HP:0004447)2.43777227
71Abnormality of lateral ventricle (HP:0030047)2.43188501
72Panhypogammaglobulinemia (HP:0003139)2.43089941
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42534475
74Parakeratosis (HP:0001036)2.42114874
75Hypochromic microcytic anemia (HP:0004840)2.41990516
76Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.41261345
77Abnormality of iron homeostasis (HP:0011031)2.39670059
78Abnormality of transition element cation homeostasis (HP:0011030)2.39620783
79Acute encephalopathy (HP:0006846)2.38941314
80Nephrogenic diabetes insipidus (HP:0009806)2.38680633
81Progressive cerebellar ataxia (HP:0002073)2.38121344
82Pancreatic cysts (HP:0001737)2.37237495
83Meningitis (HP:0001287)2.37071182
84Abnormal rod and cone electroretinograms (HP:0008323)2.36868894
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.35735314
86Hypochromic anemia (HP:0001931)2.31293792
87Tubulointerstitial nephritis (HP:0001970)2.28493920
88Bruising susceptibility (HP:0000978)2.26267391
89Mediastinal lymphadenopathy (HP:0100721)2.25920310
90Nonprogressive disorder (HP:0003680)2.24568110
91Chest pain (HP:0100749)2.22640223
92Gastrointestinal infarctions (HP:0005244)2.22498980
93Increased cerebral lipofuscin (HP:0011813)2.22190167
94Median cleft lip (HP:0000161)2.21480641
95Severe visual impairment (HP:0001141)2.19590780
96Increased serum ferritin (HP:0003281)2.19103644
97Focal seizures (HP:0007359)2.18973178
98Acanthocytosis (HP:0001927)2.17008511
99Recurrent skin infections (HP:0001581)2.16511616
100Leukocytosis (HP:0001974)2.16510472
101Chromsome breakage (HP:0040012)2.16375788
102Arterial thrombosis (HP:0004420)2.15073180
103Recurrent gram-negative bacterial infections (HP:0005420)2.14732838
104White forelock (HP:0002211)2.13782828
105Limb dystonia (HP:0002451)2.13505708
106Hepatosplenomegaly (HP:0001433)2.13227292
107Patchy hypopigmentation of hair (HP:0011365)2.12988747
108Microvesicular hepatic steatosis (HP:0001414)2.12171195
109Recurrent cutaneous fungal infections (HP:0011370)2.11918338
110Chronic mucocutaneous candidiasis (HP:0002728)2.11918338
111Increased IgE level (HP:0003212)2.11232124
112Keratoconjunctivitis sicca (HP:0001097)2.09088199
113Polyphagia (HP:0002591)2.08748145
114Vasculitis (HP:0002633)2.07935224
115Keratoconjunctivitis (HP:0001096)2.06669021
116Abnormality of the renal cortex (HP:0011035)2.06430819
117Pancreatic fibrosis (HP:0100732)2.05643610
118Abolished electroretinogram (ERG) (HP:0000550)2.05405916
119Urticaria (HP:0001025)2.04666275
120Polydipsia (HP:0001959)2.02314869
121Abnormal drinking behavior (HP:0030082)2.02314869
122Abnormality of the prostate (HP:0008775)2.01678530
123Abnormality of midbrain morphology (HP:0002418)2.00692157
124Molar tooth sign on MRI (HP:0002419)2.00692157
125Abnormality of renal resorption (HP:0011038)1.99946067
126Fair hair (HP:0002286)1.98609715
127Conjunctival telangiectasia (HP:0000524)1.97580675
128Pulmonary embolism (HP:0002204)1.97428042
129Septo-optic dysplasia (HP:0100842)1.97064159
130Dyschromatopsia (HP:0007641)1.96913102
131Generalized hypopigmentation of hair (HP:0011358)1.96615743
132Microcytic anemia (HP:0001935)1.95826578
133Abnormal pupillary function (HP:0007686)1.95627993
134Lipid accumulation in hepatocytes (HP:0006561)1.94873361
135Autoimmune hemolytic anemia (HP:0001890)1.94806964
136Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92578067
137Diplopia (HP:0000651)1.91823732
138Abnormality of binocular vision (HP:0011514)1.91823732
139Gaze-evoked nystagmus (HP:0000640)1.91731237
140Optic nerve hypoplasia (HP:0000609)1.91437502
141Esotropia (HP:0000565)1.90795061
142Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90432748
143Abnormal protein N-linked glycosylation (HP:0012347)1.90432748
144Abnormal protein glycosylation (HP:0012346)1.90432748
145Abnormal glycosylation (HP:0012345)1.90432748
146Rhinitis (HP:0012384)1.89893977
147Abnormality of the renal medulla (HP:0100957)1.89657906
148Hepatic necrosis (HP:0002605)1.89428713
149Aplasia cutis congenita (HP:0001057)1.89304175
150Progressive inability to walk (HP:0002505)1.88645156
151Inflammation of the large intestine (HP:0002037)1.87669046
152Vertigo (HP:0002321)1.86495869
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85724564
154Dry hair (HP:0011359)1.85643924
155Hemoptysis (HP:0002105)1.85605178
156Chronic otitis media (HP:0000389)1.84419248
157Exercise intolerance (HP:0003546)1.84023502
158Split foot (HP:0001839)1.83777229
159Hyperthyroidism (HP:0000836)1.82364402
160Agitation (HP:0000713)1.82224986
161Genital tract atresia (HP:0001827)1.82139443
162Vaginal atresia (HP:0000148)1.81337119
163Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81037583
164Nasolacrimal duct obstruction (HP:0000579)1.80119259
165Nephronophthisis (HP:0000090)1.79746426
166Hyperventilation (HP:0002883)1.79525832
167Abnormal sex determination (HP:0012244)1.78283176
168Sex reversal (HP:0012245)1.78283176
169Aplasia/Hypoplasia of the lens (HP:0008063)1.78241995
170Exertional dyspnea (HP:0002875)1.77901105
171Duplicated collecting system (HP:0000081)1.76895484
172Male pseudohermaphroditism (HP:0000037)1.75940303
173Poor suck (HP:0002033)1.75189074
174Generalized tonic-clonic seizures (HP:0002069)1.74243343
175Aplasia/Hypoplasia of the tibia (HP:0005772)1.74214934
176Short tibia (HP:0005736)1.73204369
177Congenital sensorineural hearing impairment (HP:0008527)1.72387096
178Absent septum pellucidum (HP:0001331)1.71116694
179Dialeptic seizures (HP:0011146)1.70949410
180Obstructive lung disease (HP:0006536)1.70809643
181Chronic obstructive pulmonary disease (HP:0006510)1.70809643
182Absence seizures (HP:0002121)1.70675432
183Abnormality of the renal collecting system (HP:0004742)1.69617369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.38184212
2TNIK4.50055615
3TAOK33.37951115
4MAP2K72.98309453
5MUSK2.97696082
6BTK2.83962381
7MKNK22.80184753
8MAP3K122.70167579
9STK162.56879982
10MAP4K12.49397572
11NTRK32.26173928
12GRK62.24288099
13FRK2.18196123
14PTK2B2.07696701
15ADRBK21.98398291
16ZAP701.93312544
17SRPK11.90469629
18MAP2K31.87668167
19CDK191.86367890
20PRPF4B1.82955163
21FES1.81314929
22MAP4K21.79957200
23CSF1R1.77534402
24IRAK31.74563070
25MAP3K111.72260789
26IRAK41.72120087
27BMX1.69859912
28MAPK131.66758024
29DAPK21.65196836
30MKNK11.63836269
31HCK1.61883661
32ITK1.58973940
33TLK11.55321498
34EPHA41.49928335
35CSK1.48731576
36IKBKB1.46171570
37GRK71.41827648
38EIF2AK31.40134238
39TXK1.35967756
40IRAK21.32621585
41TNK21.30077252
42BLK1.29191217
43BMPR21.27585709
44NEK61.22688403
45IRAK11.16900628
46YES11.16246444
47OXSR11.14057339
48JAK31.13338505
49BCKDK1.12362429
50LCK1.11463319
51BMPR1B1.11357165
52NLK1.10271684
53MAP3K41.10141448
54RIPK41.09544278
55EIF2AK21.08503501
56GRK51.07258499
57MATK1.07246526
58MAPKAPK31.05748451
59ACVR1B1.03488999
60MAPKAPK51.02901270
61TAOK11.00044820
62PIK3CG0.97760166
63NME10.97718524
64MARK10.95053755
65PLK20.93627269
66CAMKK20.93263959
67GRK10.93203945
68STK390.93123243
69PIM20.92543139
70CDK30.92021503
71TEC0.88358281
72VRK10.87589393
73PRKCQ0.87126615
74MARK30.85979915
75NTRK20.85944975
76JAK20.85252671
77NUAK10.85202588
78AKT30.85132684
79EPHB10.84696410
80CAMK2A0.83423819
81TYK20.82893171
82CAMK10.81302134
83PDK10.80840555
84PRKCG0.79360695
85CAMK2B0.78792467
86MAPK120.74664090
87UHMK10.74092752
88TBK10.72841043
89PKN10.71618485
90EPHA30.70745600
91MAP2K60.68570310
92ARAF0.67406186
93MAP3K70.66888189
94ZAK0.66564175
95BRAF0.65406565
96MARK20.65328567
97MST40.65273045
98ADRBK10.65173239
99NME20.65134746
100MAP3K140.64796328
101PINK10.64732743
102MAPK150.64226675
103TESK20.63737768
104PRKCE0.62470111
105DYRK1A0.61979951
106MAP3K130.59940390
107MAP3K30.59889675
108PNCK0.58552077
109MAP3K50.58404092
110CCNB10.55858259
111MYLK0.55499078
112PDPK10.54830441
113CAMK2D0.54738228
114CDK50.54367257
115SIK30.54077500
116RPS6KA60.53937236
117DYRK1B0.52377838
118MAP3K10.52322289
119MINK10.50190777
120FYN0.50166345
121PBK0.50049268
122INSRR0.49863196
123CDK80.49350011
124CLK10.48731687
125WNK40.48182975
126PRKD10.47002525
127DAPK10.46591742
128LYN0.46331191
129KDR0.45126635
130TIE10.44382356
131PAK10.44359983
132PRKACA0.43865605
133HIPK20.43490327
134PRKD20.43398836
135SYK0.43381950
136STK30.41182459
137STK110.39253968
138STK380.38508115
139DAPK30.38262202
140MAP2K40.38118194
141SIK20.37332097
142DYRK30.37064898
143FGR0.36938701
144PRKG10.36927675
145TAOK20.36735612
146PRKCD0.35786754
147PIM10.35591283
148RPS6KL10.34991978
149RPS6KC10.34991978
150CAMK2G0.34795353
151KIT0.34416097
152IKBKE0.33741443
153CSNK1G10.32957559
154SGK2230.29950915
155SGK4940.29950915
156DYRK20.29687768
157MAPK40.28894738
158BCR0.28007788
159PRKCA0.27180909
160CSNK1G30.26757699
161CSNK1A10.26031088
162SGK10.25955358

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77909800
2Oxidative phosphorylation_Homo sapiens_hsa001903.33525508
3Platelet activation_Homo sapiens_hsa046113.07787081
4Phototransduction_Homo sapiens_hsa047442.98415002
5Parkinsons disease_Homo sapiens_hsa050122.45822865
6Staphylococcus aureus infection_Homo sapiens_hsa051502.30349729
7Morphine addiction_Homo sapiens_hsa050322.29762658
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.27886013
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25063750
10Collecting duct acid secretion_Homo sapiens_hsa049662.19820889
11Taste transduction_Homo sapiens_hsa047422.19286176
12Synaptic vesicle cycle_Homo sapiens_hsa047212.17540028
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09238170
14Alzheimers disease_Homo sapiens_hsa050102.06180043
15Olfactory transduction_Homo sapiens_hsa047402.04510275
16GABAergic synapse_Homo sapiens_hsa047272.03611218
17Protein export_Homo sapiens_hsa030601.97589799
18Serotonergic synapse_Homo sapiens_hsa047261.91243101
19Leishmaniasis_Homo sapiens_hsa051401.88007061
20Glutamatergic synapse_Homo sapiens_hsa047241.82341231
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80397217
22Huntingtons disease_Homo sapiens_hsa050161.79972965
23Ribosome_Homo sapiens_hsa030101.74674512
24Osteoclast differentiation_Homo sapiens_hsa043801.71305185
25Nitrogen metabolism_Homo sapiens_hsa009101.60906365
26Circadian entrainment_Homo sapiens_hsa047131.56817240
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50106646
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45562081
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44562273
30Calcium signaling pathway_Homo sapiens_hsa040201.38046681
31Long-term depression_Homo sapiens_hsa047301.35869694
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35182819
33Tuberculosis_Homo sapiens_hsa051521.33593412
34B cell receptor signaling pathway_Homo sapiens_hsa046621.33240332
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32373668
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30613955
37Rheumatoid arthritis_Homo sapiens_hsa053231.29556667
38Fanconi anemia pathway_Homo sapiens_hsa034601.25988574
39Vibrio cholerae infection_Homo sapiens_hsa051101.22929649
40Amphetamine addiction_Homo sapiens_hsa050311.22648690
41Sphingolipid metabolism_Homo sapiens_hsa006001.22031555
42Salivary secretion_Homo sapiens_hsa049701.21683295
43Homologous recombination_Homo sapiens_hsa034401.20433722
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17346125
45RNA polymerase_Homo sapiens_hsa030201.12701970
46Cardiac muscle contraction_Homo sapiens_hsa042601.11759661
47Dopaminergic synapse_Homo sapiens_hsa047281.11715550
48T cell receptor signaling pathway_Homo sapiens_hsa046601.11080537
49Cholinergic synapse_Homo sapiens_hsa047251.10443661
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10126265
51Antigen processing and presentation_Homo sapiens_hsa046121.05387806
52Cocaine addiction_Homo sapiens_hsa050301.04453041
53Autoimmune thyroid disease_Homo sapiens_hsa053201.04156361
54Other glycan degradation_Homo sapiens_hsa005111.03148310
55Arachidonic acid metabolism_Homo sapiens_hsa005901.02982360
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02578316
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02326544
58Long-term potentiation_Homo sapiens_hsa047200.99279416
59Basal transcription factors_Homo sapiens_hsa030220.98681692
60Insulin secretion_Homo sapiens_hsa049110.97349449
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96258520
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95879065
63Glycerolipid metabolism_Homo sapiens_hsa005610.95681137
64Type I diabetes mellitus_Homo sapiens_hsa049400.94193529
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.90037921
66Purine metabolism_Homo sapiens_hsa002300.88852505
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88692924
68Ether lipid metabolism_Homo sapiens_hsa005650.88435837
69Proteasome_Homo sapiens_hsa030500.87583949
70Viral myocarditis_Homo sapiens_hsa054160.86461050
71Allograft rejection_Homo sapiens_hsa053300.86406431
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83353501
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81736704
74Renin secretion_Homo sapiens_hsa049240.81153358
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80303646
76African trypanosomiasis_Homo sapiens_hsa051430.78089875
77Graft-versus-host disease_Homo sapiens_hsa053320.77712813
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.76285808
79Primary immunodeficiency_Homo sapiens_hsa053400.75366685
80Toxoplasmosis_Homo sapiens_hsa051450.71511425
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71176041
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70526521
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70435992
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.70080004
85Gastric acid secretion_Homo sapiens_hsa049710.68500135
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67955750
87Lysosome_Homo sapiens_hsa041420.66246390
88Endocytosis_Homo sapiens_hsa041440.64394379
89cAMP signaling pathway_Homo sapiens_hsa040240.64323688
90Pyrimidine metabolism_Homo sapiens_hsa002400.63996834
91Asthma_Homo sapiens_hsa053100.62516448
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61437075
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.60866160
94Systemic lupus erythematosus_Homo sapiens_hsa053220.60389030
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60098740
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59561190
97Regulation of autophagy_Homo sapiens_hsa041400.58734025
98Hematopoietic cell lineage_Homo sapiens_hsa046400.58192615
99Fatty acid elongation_Homo sapiens_hsa000620.57197727
100Measles_Homo sapiens_hsa051620.57069212
101Oxytocin signaling pathway_Homo sapiens_hsa049210.56291518
102Phagosome_Homo sapiens_hsa041450.55384111
103Alcoholism_Homo sapiens_hsa050340.54983512
104VEGF signaling pathway_Homo sapiens_hsa043700.53326136
105Shigellosis_Homo sapiens_hsa051310.50875706
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.50718656
107Linoleic acid metabolism_Homo sapiens_hsa005910.50567869
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50393554
109Melanogenesis_Homo sapiens_hsa049160.50208521
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.48453084
111Herpes simplex infection_Homo sapiens_hsa051680.47536015
112Ovarian steroidogenesis_Homo sapiens_hsa049130.47504231
113N-Glycan biosynthesis_Homo sapiens_hsa005100.47205556
114Influenza A_Homo sapiens_hsa051640.47184862
115Gap junction_Homo sapiens_hsa045400.47012072
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46863713
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.46207502
118TNF signaling pathway_Homo sapiens_hsa046680.46200704
119Acute myeloid leukemia_Homo sapiens_hsa052210.45843925
120Axon guidance_Homo sapiens_hsa043600.45649481
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44590758
122Non-homologous end-joining_Homo sapiens_hsa034500.44443938
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44269532
124Legionellosis_Homo sapiens_hsa051340.43078527
125Spliceosome_Homo sapiens_hsa030400.42613871
126Dorso-ventral axis formation_Homo sapiens_hsa043200.42587176
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42318763
128MAPK signaling pathway_Homo sapiens_hsa040100.41372200
129Pertussis_Homo sapiens_hsa051330.41359547
130ABC transporters_Homo sapiens_hsa020100.41182595
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38091561
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.37301442
133Pancreatic secretion_Homo sapiens_hsa049720.34148313
134Ras signaling pathway_Homo sapiens_hsa040140.34109375
135Nucleotide excision repair_Homo sapiens_hsa034200.33838108
136Metabolic pathways_Homo sapiens_hsa011000.32529213
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31801242
138Wnt signaling pathway_Homo sapiens_hsa043100.31072707
139GnRH signaling pathway_Homo sapiens_hsa049120.30370899
140Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28308359
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27998654
142Chemokine signaling pathway_Homo sapiens_hsa040620.27165184
143Malaria_Homo sapiens_hsa051440.23905935

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