TMEM92

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)9.59300776
2regulation of retinoic acid receptor signaling pathway (GO:0048385)7.47183580
3mitotic metaphase plate congression (GO:0007080)7.28046013
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)7.02409366
5regulation of meiosis I (GO:0060631)5.80508388
6regulation of spindle organization (GO:0090224)5.77443045
7metaphase plate congression (GO:0051310)5.61005109
8protein K6-linked ubiquitination (GO:0085020)5.36732060
9regulation of exit from mitosis (GO:0007096)5.33428226
10mitotic sister chromatid segregation (GO:0000070)5.16647815
11DNA replication checkpoint (GO:0000076)5.05589188
12monoubiquitinated protein deubiquitination (GO:0035520)4.91990810
13oocyte maturation (GO:0001556)4.80706817
14regulation of histone H3-K27 methylation (GO:0061085)4.77330670
15establishment of integrated proviral latency (GO:0075713)4.70359723
16maturation of 5.8S rRNA (GO:0000460)4.68671951
17regulation of mitotic spindle organization (GO:0060236)4.67474634
18meiotic chromosome segregation (GO:0045132)4.64227220
19negative regulation of hormone biosynthetic process (GO:0032353)4.59511957
20negative regulation of hormone metabolic process (GO:0032351)4.59511957
21establishment of chromosome localization (GO:0051303)4.59223373
22positive regulation of chromosome segregation (GO:0051984)4.56635219
23protein localization to kinetochore (GO:0034501)4.50573271
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.48266076
25negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.45410795
26negative regulation of DNA-templated transcription, elongation (GO:0032785)4.45410795
27mitotic chromosome condensation (GO:0007076)4.43290494
28purine nucleobase biosynthetic process (GO:0009113)4.34883539
29regulation of sister chromatid cohesion (GO:0007063)4.31989967
30protein localization to chromosome, centromeric region (GO:0071459)4.26626174
31negative regulation of telomere maintenance (GO:0032205)4.26061003
32regulation of meiosis (GO:0040020)4.23987846
33DNA damage response, signal transduction resulting in transcription (GO:0042772)4.21614841
34regulation of chromosome segregation (GO:0051983)4.20836623
35protein localization to chromosome (GO:0034502)4.20239149
36sister chromatid segregation (GO:0000819)4.19005781
37DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.15929815
38mitotic nuclear envelope disassembly (GO:0007077)4.15450396
39negative regulation of meiosis (GO:0045835)4.15053517
40resolution of meiotic recombination intermediates (GO:0000712)4.13324870
41establishment of viral latency (GO:0019043)4.13308842
42proteasome assembly (GO:0043248)4.11239889
43attachment of spindle microtubules to kinetochore (GO:0008608)4.09358314
44regulation of guanylate cyclase activity (GO:0031282)4.04355016
45angiotensin maturation (GO:0002003)4.02641590
46cobalamin metabolic process (GO:0009235)4.00897632
47piRNA metabolic process (GO:0034587)3.99641975
48meiosis I (GO:0007127)3.99546433
49NADH metabolic process (GO:0006734)3.90151010
50nuclear envelope disassembly (GO:0051081)3.89515970
51membrane disassembly (GO:0030397)3.89515970
52chromosome segregation (GO:0007059)3.88224824
53spindle checkpoint (GO:0031577)3.88189008
54chaperone-mediated protein transport (GO:0072321)3.83379683
55histone H2A monoubiquitination (GO:0035518)3.81112165
56regulation of glucocorticoid metabolic process (GO:0031943)3.79102580
57very-low-density lipoprotein particle assembly (GO:0034379)3.76825387
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.74963822
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.74963822
60positive regulation of mitotic sister chromatid separation (GO:1901970)3.74963822
61DNA damage induced protein phosphorylation (GO:0006975)3.73205008
62regulation of mitochondrial translation (GO:0070129)3.70048499
63microtubule depolymerization (GO:0007019)3.69719848
64regulation of telomere maintenance via telomerase (GO:0032210)3.67678365
65inner cell mass cell proliferation (GO:0001833)3.66311755
66regulation of RIG-I signaling pathway (GO:0039535)3.65854203
67nucleobase biosynthetic process (GO:0046112)3.64870913
68male meiosis I (GO:0007141)3.64187049
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63439522
70intestinal absorption (GO:0050892)3.62586216
71CENP-A containing nucleosome assembly (GO:0034080)3.61880607
72female gamete generation (GO:0007292)3.61067761
73L-ascorbic acid metabolic process (GO:0019852)3.56544742
74synaptonemal complex assembly (GO:0007130)3.55505662
75regulation of meiotic cell cycle (GO:0051445)3.53555073
76folic acid metabolic process (GO:0046655)3.52246835
77DNA replication-independent nucleosome organization (GO:0034724)3.48120056
78DNA replication-independent nucleosome assembly (GO:0006336)3.48120056
79male meiosis (GO:0007140)3.47992056
80chromatin remodeling at centromere (GO:0031055)3.47150076
81mitotic spindle checkpoint (GO:0071174)3.46365795
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45726204
83regulation of transcription from RNA polymerase I promoter (GO:0006356)3.44592643
84histone exchange (GO:0043486)3.41227067
85kinetochore assembly (GO:0051382)3.39925003
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39166696
87negative regulation of chromosome segregation (GO:0051985)3.37600686
88positive regulation of megakaryocyte differentiation (GO:0045654)3.37429871
89ribosome assembly (GO:0042255)3.37418772
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33506325
91regulation of cellular amino acid metabolic process (GO:0006521)3.33478933
92meiotic cell cycle process (GO:1903046)3.32992804
93sister chromatid cohesion (GO:0007062)3.32946625
94negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.32308604
95negative regulation of sister chromatid segregation (GO:0033046)3.32308604
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.32308604
97negative regulation of mitotic sister chromatid segregation (GO:0033048)3.32308604
98regulation of mitotic metaphase/anaphase transition (GO:0030071)3.31323330
99epoxygenase P450 pathway (GO:0019373)3.30045571
100transcription elongation from RNA polymerase III promoter (GO:0006385)3.28724620
101termination of RNA polymerase III transcription (GO:0006386)3.28724620
102maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.27415631
103nucleotide-sugar biosynthetic process (GO:0009226)3.27011883
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26588387
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26152052
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25942432
107negative regulation of ligase activity (GO:0051352)3.25942432
108meiotic nuclear division (GO:0007126)3.25376578
109anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25299902
110glucuronate metabolic process (GO:0019585)3.24532058
111uronic acid metabolic process (GO:0006063)3.24532058
112histone H2A ubiquitination (GO:0033522)3.24028644
113protein maturation by protein folding (GO:0022417)3.23921826
114DNA replication initiation (GO:0006270)3.23513016
115rRNA modification (GO:0000154)3.23252629
116regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)3.23152986
117vitamin transmembrane transport (GO:0035461)3.22068462
118snRNA transcription (GO:0009301)3.22024538
119nuclear envelope organization (GO:0006998)3.21831849
120kinetochore organization (GO:0051383)3.21646572
121positive regulation of guanylate cyclase activity (GO:0031284)3.20204351
122regulation of sister chromatid segregation (GO:0033045)3.18269212
123regulation of mitotic sister chromatid separation (GO:0010965)3.18269212
124regulation of mitotic sister chromatid segregation (GO:0033047)3.18269212
125regulation of spindle checkpoint (GO:0090231)3.17580722
126mitotic sister chromatid cohesion (GO:0007064)3.17515540
127meiotic cell cycle (GO:0051321)3.16196653
128synaptonemal complex organization (GO:0070193)3.15042446
129transcription from mitochondrial promoter (GO:0006390)3.15009291
130regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.14933547
131transcription elongation from RNA polymerase II promoter (GO:0006368)3.13788391
132calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.12123058
133positive regulation of pseudopodium assembly (GO:0031274)3.09518710
134establishment of protein localization to mitochondrial membrane (GO:0090151)3.08911757
135fat-soluble vitamin biosynthetic process (GO:0042362)3.08408611
136cellular glucuronidation (GO:0052695)3.07184663
137regulation of bile acid biosynthetic process (GO:0070857)3.07100201
138GDP-mannose metabolic process (GO:0019673)3.06701849
139rRNA methylation (GO:0031167)3.04963571
140fructose metabolic process (GO:0006000)2.92258315
141plasma lipoprotein particle assembly (GO:0034377)2.91200422
142positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90843422
143glutathione derivative metabolic process (GO:1901685)2.89835143
144glutathione derivative biosynthetic process (GO:1901687)2.89835143
145positive regulation of glycoprotein metabolic process (GO:1903020)2.84271749
146ribosomal large subunit biogenesis (GO:0042273)2.84165456
147DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82314560
148vitamin transport (GO:0051180)2.81501912
149drug metabolic process (GO:0017144)2.80558384
150positive regulation of glycoprotein biosynthetic process (GO:0010560)2.79940548
151positive regulation of ligase activity (GO:0051351)2.76962604
152signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76214467
153signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76214467
154signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76214467
155ventricular cardiac muscle cell development (GO:0055015)2.76110453
156protein targeting to mitochondrion (GO:0006626)2.75951552
157digestion (GO:0007586)2.75735379
158galactose catabolic process (GO:0019388)2.75384585
159signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75003642
160intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75003642
161nucleoside transmembrane transport (GO:1901642)2.74316621
162activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.71875954
163daunorubicin metabolic process (GO:0044597)2.71637608
164polyketide metabolic process (GO:0030638)2.71637608
165doxorubicin metabolic process (GO:0044598)2.71637608
166respiratory chain complex IV assembly (GO:0008535)2.70442667
167homocysteine metabolic process (GO:0050667)2.67510229
168regulation of pseudopodium assembly (GO:0031272)2.65314000
169vitamin biosynthetic process (GO:0009110)2.64462492
170bundle of His cell to Purkinje myocyte communication (GO:0086069)2.64150900
171urea cycle (GO:0000050)2.62975847
172signal transduction involved in DNA damage checkpoint (GO:0072422)2.62521243
173signal transduction involved in DNA integrity checkpoint (GO:0072401)2.62521243
174regulation of ubiquitin-protein transferase activity (GO:0051438)2.62047190
175mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59973814
176protein autoprocessing (GO:0016540)2.59272463
177respiratory electron transport chain (GO:0022904)2.56883983
178telomere maintenance via semi-conservative replication (GO:0032201)2.56674322
179ATP synthesis coupled proton transport (GO:0015986)2.56613205
180energy coupled proton transport, down electrochemical gradient (GO:0015985)2.56613205
181urea metabolic process (GO:0019627)2.55805720
182signal transduction involved in cell cycle checkpoint (GO:0072395)2.55598831
183transcytosis (GO:0045056)2.54225528
184negative regulation of gene silencing (GO:0060969)2.53149880
185regulation of ligase activity (GO:0051340)2.51587628
186electron transport chain (GO:0022900)2.50135461
187monosaccharide catabolic process (GO:0046365)2.49421322
188regulation of cellular amine metabolic process (GO:0033238)2.49126312
189negative regulation of keratinocyte proliferation (GO:0010839)2.48987564
190hormone catabolic process (GO:0042447)2.45397179
191cytochrome complex assembly (GO:0017004)2.45253080
192nucleoside transport (GO:0015858)2.45012220
193regulation of cholesterol esterification (GO:0010872)2.42783798
194positive regulation of actin filament depolymerization (GO:0030836)2.42570202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.64027759
2E2F7_22180533_ChIP-Seq_HELA_Human6.24492566
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.13357159
4KAP1_22055183_ChIP-Seq_ESCs_Mouse4.85824584
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.32060615
6AR_21909140_ChIP-Seq_LNCAP_Human3.62893401
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37075850
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.30901127
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.04779345
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.88443976
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75720492
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.75526905
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70410663
14NANOG_18555785_ChIP-Seq_MESCs_Mouse2.67300455
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65350471
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59292347
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49107208
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.45566503
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41223045
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39451154
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.19494247
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12569734
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.11048252
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.11048252
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.11048252
26CDX2_20551321_ChIP-Seq_CACO-2_Human2.08625522
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05138182
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.98110982
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.93441390
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89225684
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87111668
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84516613
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.82764719
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.79404801
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79268597
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.74009895
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.72603643
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71971059
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68206475
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.67144150
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66041900
42ELK1_19687146_ChIP-ChIP_HELA_Human1.64293074
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64122166
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63631589
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61800843
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58194436
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.57375725
48GATA4_25053715_ChIP-Seq_YYC3_Human1.55324380
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.54889273
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52777091
51GATA6_25053715_ChIP-Seq_YYC3_Human1.52665062
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52177135
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50263615
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44832010
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42928656
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42669797
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.38665290
58KAP1_27257070_Chip-Seq_ESCs_Mouse1.38302678
59XRN2_22483619_ChIP-Seq_HELA_Human1.37741043
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.37646753
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35107422
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33928543
63ZNF263_19887448_ChIP-Seq_K562_Human1.33261931
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32422020
65GABP_19822575_ChIP-Seq_HepG2_Human1.31881479
66TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30239828
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29446461
68VDR_23849224_ChIP-Seq_CD4+_Human1.29427328
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29209654
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24843494
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23120014
72RUNX1_26923725_Chip-Seq_HPCs_Mouse1.22876420
73* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22009011
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21766132
75MYC_18940864_ChIP-ChIP_HL60_Human1.21465002
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19829711
77KDM5A_27292631_Chip-Seq_BREAST_Human1.19463464
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18160666
79NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18044757
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15716109
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15586157
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14963466
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.13600467
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.13058030
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12578172
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11933351
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11861282
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11818135
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.10875337
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08226303
91RXR_22158963_ChIP-Seq_LIVER_Mouse1.07254347
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05451488
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05301054
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04122955
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01357114
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01329103
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99999005
98* SOX2_20726797_ChIP-Seq_SW620_Human0.99979649
99* EOMES_21245162_ChIP-Seq_HESCs_Human0.97891998
100* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97078791
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96551315
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95413333
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94956532
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93059334
105* ATF3_27146783_Chip-Seq_COLON_Human0.92938119
106* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92870500
107NANOG_18692474_ChIP-Seq_MESCs_Mouse0.91029513
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90938035
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90634347
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89718448
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89708810
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89167279
113SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88950594
114TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87991382
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.87878034
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87112247
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87023671
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86182109
119SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.85718037
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85211084
121* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84916949
122ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84069643
123FOXP3_21729870_ChIP-Seq_TREG_Human0.83680479
124SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83603106
125TTF2_22483619_ChIP-Seq_HELA_Human0.83490159
126SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83239148
127FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83152954
128STAT1_17558387_ChIP-Seq_HELA_Human0.81975717
129GATA3_21867929_ChIP-Seq_TH1_Mouse0.81593357
130TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.81272931
131NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80882256
132PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78609500
133HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78044103
134AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76704516
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.75584555
136SRF_21415370_ChIP-Seq_HL-1_Mouse0.74945621
137POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.74622318
138ERG_20517297_ChIP-Seq_VCAP_Human0.74275397
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.73935961
140STAT3_18555785_ChIP-Seq_MESCs_Mouse0.73409546
141SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.73252212
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71895464
143SOX2_18692474_ChIP-Seq_MESCs_Mouse0.71882046
144DCP1A_22483619_ChIP-Seq_HELA_Human0.69316117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.06762052
2MP0003693_abnormal_embryo_hatching5.94325169
3MP0005451_abnormal_body_composition4.96155539
4MP0002102_abnormal_ear_morphology4.68203607
5MP0003718_maternal_effect4.21989949
6MP0003111_abnormal_nucleus_morphology4.05949429
7MP0010094_abnormal_chromosome_stability3.75313455
8MP0001666_abnormal_nutrient_absorption3.73293399
9MP0005085_abnormal_gallbladder_physiolo3.72407406
10MP0003077_abnormal_cell_cycle3.71263765
11MP0004957_abnormal_blastocyst_morpholog3.53919487
12MP0003646_muscle_fatigue3.42448782
13MP0004019_abnormal_vitamin_homeostasis3.32030238
14MP0002139_abnormal_hepatobiliary_system3.21355331
15MP0003123_paternal_imprinting3.21337596
16MP0009379_abnormal_foot_pigmentation3.20516817
17MP0002653_abnormal_ependyma_morphology2.89740064
18MP0005365_abnormal_bile_salt2.81318849
19MP0008877_abnormal_DNA_methylation2.79690189
20MP0003941_abnormal_skin_development2.72303035
21MP0003806_abnormal_nucleotide_metabolis2.60511298
22MP0006292_abnormal_olfactory_placode2.54886593
23MP0008057_abnormal_DNA_replication2.53723135
24MP0008007_abnormal_cellular_replicative2.45583687
25MP0008932_abnormal_embryonic_tissue2.21243320
26MP0008058_abnormal_DNA_repair2.18332223
27MP0002254_reproductive_system_inflammat2.14877164
28MP0001730_embryonic_growth_arrest2.14814168
29MP0004147_increased_porphyrin_level2.05974002
30MP0005408_hypopigmentation1.96701428
31MP0002796_impaired_skin_barrier1.92961749
32MP0005395_other_phenotype1.92262572
33MP0002210_abnormal_sex_determination1.86486777
34MP0000462_abnormal_digestive_system1.85850446
35MP0008875_abnormal_xenobiotic_pharmacok1.84362683
36MP0001929_abnormal_gametogenesis1.82821928
37MP0000350_abnormal_cell_proliferation1.82475903
38MP0001764_abnormal_homeostasis1.81739314
39MP0000653_abnormal_sex_gland1.81683426
40MP0001119_abnormal_female_reproductive1.79444348
41MP0003937_abnormal_limbs/digits/tail_de1.74437460
42MP0003699_abnormal_female_reproductive1.71300772
43MP0010307_abnormal_tumor_latency1.71086336
44MP0005332_abnormal_amino_acid1.68063775
45MP0009697_abnormal_copulation1.61926267
46MP0010352_gastrointestinal_tract_polyps1.61616356
47MP0002085_abnormal_embryonic_tissue1.57938395
48MP0001145_abnormal_male_reproductive1.57854429
49MP0003191_abnormal_cellular_cholesterol1.56693273
50MP0002249_abnormal_larynx_morphology1.56632298
51MP0003315_abnormal_perineum_morphology1.55546383
52MP0001672_abnormal_embryogenesis/_devel1.54924905
53MP0005380_embryogenesis_phenotype1.54924905
54MP0001697_abnormal_embryo_size1.54618151
55MP0005501_abnormal_skin_physiology1.46715216
56MP0002138_abnormal_hepatobiliary_system1.45675705
57MP0003186_abnormal_redox_activity1.41307109
58MP0008260_abnormal_autophagy1.40960301
59MP0002084_abnormal_developmental_patter1.40799390
60MP0002277_abnormal_respiratory_mucosa1.39024195
61MP0001293_anophthalmia1.36222347
62MP0004185_abnormal_adipocyte_glucose1.35676564
63MP0003786_premature_aging1.28899169
64MP0003984_embryonic_growth_retardation1.26818197
65MP0002088_abnormal_embryonic_growth/wei1.21524404
66MP0010329_abnormal_lipoprotein_level1.19490862
67MP0003221_abnormal_cardiomyocyte_apopto1.19418017
68MP0006036_abnormal_mitochondrial_physio1.18533819
69MP0001881_abnormal_mammary_gland1.17967272
70MP0001529_abnormal_vocalization1.17456606
71MP0003938_abnormal_ear_development1.16272940
72MP0002080_prenatal_lethality1.16081028
73MP0003121_genomic_imprinting1.15046123
74MP0008872_abnormal_physiological_respon1.14063032
75MP0009333_abnormal_splenocyte_physiolog1.11693968
76MP0003183_abnormal_peptide_metabolism1.08517966
77MP0002161_abnormal_fertility/fecundity1.07924907
78MP0000579_abnormal_nail_morphology1.06243851
79MP0002086_abnormal_extraembryonic_tissu1.06042346
80MP0001188_hyperpigmentation1.06003644
81MP0001986_abnormal_taste_sensitivity1.05733290
82MP0003950_abnormal_plasma_membrane1.05270210
83MP0002877_abnormal_melanocyte_morpholog1.04224268
84MP0001849_ear_inflammation1.03737265
85MP0000477_abnormal_intestine_morphology1.03678114
86MP0003252_abnormal_bile_duct1.02954492
87MP0009643_abnormal_urine_homeostasis1.02188060
88MP0005310_abnormal_salivary_gland0.99897928
89MP0003195_calcinosis0.97182544
90MP0010030_abnormal_orbit_morphology0.96211446
91MP0005636_abnormal_mineral_homeostasis0.94831625
92MP0001664_abnormal_digestion0.94206644
93MP0003698_abnormal_male_reproductive0.93600378
94MP0002876_abnormal_thyroid_physiology0.93194911
95MP0004272_abnormal_basement_membrane0.92520821
96MP0009840_abnormal_foam_cell0.91832669
97MP0004264_abnormal_extraembryonic_tissu0.90996796
98MP0000566_synostosis0.90620369
99MP0000678_abnormal_parathyroid_gland0.89365156
100MP0000762_abnormal_tongue_morphology0.88814188
101MP0003755_abnormal_palate_morphology0.88635701
102MP0010155_abnormal_intestine_physiology0.88376982
103MP0005670_abnormal_white_adipose0.85413107
104MP0005165_increased_susceptibility_to0.84295634
105MP0002638_abnormal_pupillary_reflex0.84111805
106MP0003656_abnormal_erythrocyte_physiolo0.82711786
107MP0003787_abnormal_imprinting0.82703105
108MP0005621_abnormal_cell_physiology0.82127341
109MP0008004_abnormal_stomach_pH0.81690174
110MP0009672_abnormal_birth_weight0.81471644
111MP0006035_abnormal_mitochondrial_morpho0.81171336
112MP0001485_abnormal_pinna_reflex0.79353607
113MP0008995_early_reproductive_senescence0.79345648
114MP0003638_abnormal_response/metabolism_0.78905390
115MP0002019_abnormal_tumor_incidence0.78713712
116MP0005319_abnormal_enzyme/_coenzyme0.74971117
117MP0010234_abnormal_vibrissa_follicle0.74855854
118MP0000537_abnormal_urethra_morphology0.74771701
119MP0005584_abnormal_enzyme/coenzyme_acti0.74394598
120MP0004782_abnormal_surfactant_physiolog0.74030323
121MP0000490_abnormal_crypts_of0.73997872
122MP0003878_abnormal_ear_physiology0.72362981
123MP0005377_hearing/vestibular/ear_phenot0.72362981
124MP0000647_abnormal_sebaceous_gland0.71651144
125MP0005410_abnormal_fertilization0.70951467
126MP0005257_abnormal_intraocular_pressure0.70504064
127MP0001216_abnormal_epidermal_layer0.69945299
128MP0000627_abnormal_mammary_gland0.68817462
129MP0000609_abnormal_liver_physiology0.68630234
130MP0005330_cardiomyopathy0.66575409
131MP0000313_abnormal_cell_death0.66302782
132MP0005647_abnormal_sex_gland0.65108325
133MP0005083_abnormal_biliary_tract0.64634064
134MP0003935_abnormal_craniofacial_develop0.63678977
135MP0005384_cellular_phenotype0.62875703
136MP0005367_renal/urinary_system_phenotyp0.62773181
137MP0000516_abnormal_urinary_system0.62773181
138MP0000639_abnormal_adrenal_gland0.62697937
139MP0000432_abnormal_head_morphology0.62395480
140MP0005166_decreased_susceptibility_to0.62377050
141MP0005076_abnormal_cell_differentiation0.62350221
142MP0002233_abnormal_nose_morphology0.62013244
143MP0002132_abnormal_respiratory_system0.61795687
144MP0002396_abnormal_hematopoietic_system0.61626496
145MP0005187_abnormal_penis_morphology0.60710374
146MP0003936_abnormal_reproductive_system0.60625212
147MP0003861_abnormal_nervous_system0.59474914
148MP0001915_intracranial_hemorrhage0.58616702
149MP0002163_abnormal_gland_morphology0.57681099
150MP0003119_abnormal_digestive_system0.57470432
151MP0005389_reproductive_system_phenotype0.56097406
152MP0003890_abnormal_embryonic-extraembry0.53502606
153MP0002127_abnormal_cardiovascular_syste0.53042922
154MP0002160_abnormal_reproductive_system0.51774375
155MP0001346_abnormal_lacrimal_gland0.50677799
156MP0001851_eye_inflammation0.49775992
157MP0001727_abnormal_embryo_implantation0.49509558
158MP0002111_abnormal_tail_morphology0.47211630
159MP0009250_abnormal_appendicular_skeleto0.46190541
160MP0005397_hematopoietic_system_phenotyp0.45739479
161MP0001545_abnormal_hematopoietic_system0.45739479
162MP0001661_extended_life_span0.45261129
163MP0002938_white_spotting0.44601314
164MP0006138_congestive_heart_failure0.44231442

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.68528917
2Breast hypoplasia (HP:0003187)6.02447736
3Abnormality of glutamine family amino acid metabolism (HP:0010902)5.48459291
4Facial hemangioma (HP:0000329)5.47826693
5Abnormality of the labia minora (HP:0012880)5.11451072
6Patellar aplasia (HP:0006443)4.69728534
7Aplasia/Hypoplasia of the patella (HP:0006498)4.46402182
8Carpal bone hypoplasia (HP:0001498)4.44557898
9Male infertility (HP:0003251)4.25570393
10Shawl scrotum (HP:0000049)4.04328512
11Capillary hemangiomas (HP:0005306)3.99075146
12Ileus (HP:0002595)3.96191129
13Hydroxyprolinuria (HP:0003080)3.87433125
14Abnormality of proline metabolism (HP:0010907)3.87433125
15Meckel diverticulum (HP:0002245)3.79696598
16Atrioventricular block (HP:0001678)3.79357489
17Abnormality of the preputium (HP:0100587)3.78455143
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78330388
19Chromsome breakage (HP:0040012)3.70012444
20Hypobetalipoproteinemia (HP:0003563)3.64383423
21Aplasia/Hypoplasia of the uvula (HP:0010293)3.62627153
22Abnormality of urine glucose concentration (HP:0011016)3.52773158
23Glycosuria (HP:0003076)3.52773158
24Abnormality of the vitamin B12 metabolism (HP:0004341)3.52002571
25Malnutrition (HP:0004395)3.50718640
26Abnormality of the ileum (HP:0001549)3.49867406
27Abnormality of chromosome stability (HP:0003220)3.46771108
28Reduced antithrombin III activity (HP:0001976)3.33656468
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.31993410
30Breast aplasia (HP:0100783)3.29232046
31Absent radius (HP:0003974)3.25615326
32Secondary amenorrhea (HP:0000869)3.22639112
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.21599551
34Oral leukoplakia (HP:0002745)3.21212984
35Abnormality of vitamin B metabolism (HP:0004340)3.20984663
36Adrenal hypoplasia (HP:0000835)3.19247103
37Aplasia/Hypoplasia of the breasts (HP:0010311)3.17952029
38Flat capital femoral epiphysis (HP:0003370)3.13714527
39Megaloblastic anemia (HP:0001889)3.10505910
40Absent forearm bone (HP:0003953)3.07011241
41Aplasia involving forearm bones (HP:0009822)3.07011241
42Oligodactyly (hands) (HP:0001180)3.06861671
43Oligodactyly (HP:0012165)3.05726561
44Papillary thyroid carcinoma (HP:0002895)3.04039262
45Prostate neoplasm (HP:0100787)2.99463749
46Acute encephalopathy (HP:0006846)2.98404503
47Gout (HP:0001997)2.96527787
48Delayed CNS myelination (HP:0002188)2.96264325
49Confusion (HP:0001289)2.95732554
50Nausea (HP:0002018)2.90863727
51Reticulocytopenia (HP:0001896)2.89725227
52Fat malabsorption (HP:0002630)2.89338285
53Acute necrotizing encephalopathy (HP:0006965)2.87943395
54Hyperglycinuria (HP:0003108)2.87381877
55Type I transferrin isoform profile (HP:0003642)2.86625269
56Abnormal mitochondria in muscle tissue (HP:0008316)2.86147624
57Abnormality of glycine metabolism (HP:0010895)2.83794719
58Abnormality of serine family amino acid metabolism (HP:0010894)2.83794719
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76978981
60Mitochondrial inheritance (HP:0001427)2.75858981
61Abnormality of lateral ventricle (HP:0030047)2.73493454
62Premature ovarian failure (HP:0008209)2.73223974
63Small intestinal stenosis (HP:0012848)2.72574624
64Duodenal stenosis (HP:0100867)2.72574624
65Increased hepatocellular lipid droplets (HP:0006565)2.70649090
66Cerebral edema (HP:0002181)2.69793103
67Abdominal situs inversus (HP:0003363)2.68766312
68Abnormality of abdominal situs (HP:0011620)2.68766312
69Aplasia/Hypoplasia involving the musculature (HP:0001460)2.68046780
70Hepatocellular necrosis (HP:0001404)2.67744072
71Increased serum pyruvate (HP:0003542)2.65386693
72Increased CSF lactate (HP:0002490)2.64929728
73Methylmalonic aciduria (HP:0012120)2.64551979
74Impulsivity (HP:0100710)2.64383325
75Overlapping toe (HP:0001845)2.64085832
76Myelodysplasia (HP:0002863)2.62874858
77Supernumerary spleens (HP:0009799)2.61307508
78Abnormality of vitamin metabolism (HP:0100508)2.61222531
79Hyperphosphaturia (HP:0003109)2.61153346
80Sparse eyelashes (HP:0000653)2.58035516
81Pancreatic fibrosis (HP:0100732)2.55891055
82Abnormality of serum amino acid levels (HP:0003112)2.54378282
83Heart block (HP:0012722)2.54345326
84Lethargy (HP:0001254)2.52889546
85Macrocytic anemia (HP:0001972)2.52230343
86Cerebral hypomyelination (HP:0006808)2.51992533
87Rough bone trabeculation (HP:0100670)2.48565744
88Right ventricular cardiomyopathy (HP:0011663)2.46343378
89Acute myeloid leukemia (HP:0004808)2.43828651
90Steatorrhea (HP:0002570)2.42934707
91Hepatic necrosis (HP:0002605)2.42589215
92Clubbing of toes (HP:0100760)2.42276866
93Abnormality of sulfur amino acid metabolism (HP:0004339)2.38665715
94Aplasia/Hypoplasia of the sternum (HP:0006714)2.37989707
95Renal Fanconi syndrome (HP:0001994)2.37841098
96Abnormal urine phosphate concentration (HP:0012599)2.37642035
97Ectopic kidney (HP:0000086)2.37373937
98Intrahepatic cholestasis (HP:0001406)2.37148861
99Pendular nystagmus (HP:0012043)2.36715892
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36621055
101Abnormality of pyrimidine metabolism (HP:0004353)2.35408659
102Abnormal atrioventricular conduction (HP:0005150)2.34031905
103Absent thumb (HP:0009777)2.32002983
104Bone marrow hypocellularity (HP:0005528)2.30308502
105Abnormality of nucleobase metabolism (HP:0010932)2.29917496
106Lipid accumulation in hepatocytes (HP:0006561)2.29597042
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29129587
108Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29129587
109Horseshoe kidney (HP:0000085)2.28640276
110Hypolipoproteinemia (HP:0010981)2.27689135
111Azoospermia (HP:0000027)2.27570447
112Abnormality of purine metabolism (HP:0004352)2.27400714
113Abnormal spermatogenesis (HP:0008669)2.24937068
114Patent foramen ovale (HP:0001655)2.24503569
115Microglossia (HP:0000171)2.23620619
116Short thumb (HP:0009778)2.21948563
117Abnormality of the carotid arteries (HP:0005344)2.21842428
118Abnormality of glycolysis (HP:0004366)2.21091563
119Wrist flexion contracture (HP:0001239)2.20993132
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19697237
121Abnormal protein N-linked glycosylation (HP:0012347)2.19697237
122Abnormal protein glycosylation (HP:0012346)2.19697237
123Abnormal glycosylation (HP:0012345)2.19697237
124Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19078196
125Increased serum lactate (HP:0002151)2.18293309
126Ankle contracture (HP:0006466)2.14862814
127Cystic hygroma (HP:0000476)2.14766645
128Pulmonary fibrosis (HP:0002206)2.14630983
129Abnormality of magnesium homeostasis (HP:0004921)2.14285102
130Lactic acidosis (HP:0003128)2.11141567
131Posterior subcapsular cataract (HP:0007787)2.11000704
132Sparse lateral eyebrow (HP:0005338)2.10571753
133Progressive macrocephaly (HP:0004481)2.09662211
134Hypoplasia of the uterus (HP:0000013)2.09485194
135Metabolic acidosis (HP:0001942)2.09119243
136Abnormality of chromosome segregation (HP:0002916)2.08010943
137Abnormality of the duodenum (HP:0002246)2.07633854
138Abnormal umbilical cord blood vessels (HP:0011403)2.06703836
139Single umbilical artery (HP:0001195)2.06703836
140Abnormality of the fetal cardiovascular system (HP:0010948)2.06703836
141Pili torti (HP:0003777)2.06472522
142Cafe-au-lait spot (HP:0000957)2.06277469
143Complete atrioventricular canal defect (HP:0001674)2.05647452
144Vascular calcification (HP:0004934)2.04067453
145Abnormal trabecular bone morphology (HP:0100671)2.03684868
146Symptomatic seizures (HP:0011145)2.02335639
147Aplastic anemia (HP:0001915)2.00624849
148Widely patent fontanelles and sutures (HP:0004492)1.99959950
149CNS hypomyelination (HP:0003429)1.99867113
150Microretrognathia (HP:0000308)1.99457872
151Sandal gap (HP:0001852)1.98470399
152Hypoplasia of the fovea (HP:0007750)1.98211436
153Aplasia/Hypoplasia of the fovea (HP:0008060)1.98211436
154High anterior hairline (HP:0009890)1.98053623
155Abnormality of cochlea (HP:0000375)1.97736530
156Breech presentation (HP:0001623)1.97632455
157Irregular epiphyses (HP:0010582)1.97627254
158Triphalangeal thumb (HP:0001199)1.97576264
159Respiratory difficulties (HP:0002880)1.97546037
160Congenital ichthyosiform erythroderma (HP:0007431)1.97156238
161Multiple enchondromatosis (HP:0005701)1.96119401
162Increased intramyocellular lipid droplets (HP:0012240)1.95729993
163Abnormality of the umbilical cord (HP:0010881)1.95113727
164Abnormality of DNA repair (HP:0003254)1.94927666
165Acanthocytosis (HP:0001927)1.94319791
166Bicornuate uterus (HP:0000813)1.94180987
167Abnormality of the fingertips (HP:0001211)1.93738294
168Rib fusion (HP:0000902)1.93086714
169Proximal tubulopathy (HP:0000114)1.92681998
170Sloping forehead (HP:0000340)1.92241402
171Tetraplegia (HP:0002445)1.90398416
172Hypoglycemic seizures (HP:0002173)1.89259799
173Wide cranial sutures (HP:0010537)1.88810763
174Tracheoesophageal fistula (HP:0002575)1.87886953
175Xanthomatosis (HP:0000991)1.87086591
176Aplasia/hypoplasia of the uterus (HP:0008684)1.85340270
177Abnormalities of placenta or umbilical cord (HP:0001194)1.84689761
178Abnormal lung lobation (HP:0002101)1.84448650
179Slender long bone (HP:0003100)1.82965645
180Colon cancer (HP:0003003)1.82496098
181Hyperglycinemia (HP:0002154)1.82038716
182Arteriovenous malformation (HP:0100026)1.81697914
183Hyperuricemia (HP:0002149)1.81484860
184Increased purine levels (HP:0004368)1.81484860
185Segmental peripheral demyelination/remyelination (HP:0003481)1.80908333
186Aplasia/hypoplasia of the humerus (HP:0006507)1.78494169
187Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75095416
188Abnormality of the proximal phalanges of the hand (HP:0009834)1.74059959
189Tetany (HP:0001281)1.73631604
190Abnormality of the clitoris (HP:0000056)1.70642152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS24.19458012
2VRK24.08763976
3MST1R3.78323944
4KSR23.44771114
5MST43.28470845
6PBK3.20947056
7EEF2K3.19598456
8PLK43.15061573
9MUSK3.13489950
10NEK23.06828120
11LATS12.98935047
12LMTK22.93594579
13BUB12.90021220
14TTK2.74083759
15PDK22.73305204
16BRAF2.67664445
17NME22.62915703
18ERBB42.61735045
19STK38L2.59590640
20RAF12.56676958
21CDC72.45236685
22WEE12.43845845
23BRSK22.41560432
24STK162.38773554
25TNIK2.23069438
26MAP3K62.22761820
27TAOK12.22182237
28MAP3K122.13404465
29MAP3K92.10882084
30MAPKAPK32.09586366
31TESK12.08355312
32PAK61.98810972
33PLK11.93494147
34NME11.89905493
35ARAF1.88724473
36STK31.82934072
37KSR11.75998094
38BRSK11.72214463
39MET1.62796746
40PLK31.56048277
41CHEK21.55430527
42SRPK11.54647881
43TAF11.51314687
44PRKG21.49547624
45ACVR1B1.45867285
46CDK121.41270642
47AKT31.36470315
48AURKB1.35453729
49EIF2AK11.29931834
50DYRK21.29731114
51TRIM281.27503224
52NEK11.27338557
53PAK41.25680248
54BMX1.25506894
55MELK1.25016544
56DYRK31.23222651
57RPS6KB21.17416626
58MAP3K131.15858718
59DAPK11.12815106
60MKNK21.12543535
61CDK91.11375048
62CDK191.10945531
63AURKA1.09813577
64OXSR11.08297020
65LIMK11.08165416
66ZAK1.04880447
67VRK11.03693627
68CDK81.02113432
69ERN10.97822588
70CDK30.97789269
71MAP3K80.92526479
72ABL20.92494168
73CHEK10.89456031
74EPHB20.88744284
75MAPKAPK50.85556779
76STK380.84915039
77TAOK30.83108640
78BMPR1B0.82914485
79RPS6KA40.82577532
80BCKDK0.79295432
81MYLK0.70338460
82STK100.67625665
83PRKAA20.67594469
84CDK70.66939261
85PTK20.66921125
86PRKAA10.66247350
87STK390.62881819
88PINK10.61835132
89TRPM70.61503771
90PRKCI0.61035198
91MAPK130.60786487
92MAP2K70.60032998
93CDK20.58033198
94KDR0.57874965
95STK40.57758057
96PRKD30.57447177
97CDK40.57085203
98PIM20.56762830
99PAK10.56096665
100WNK30.54966790
101ATM0.53801057
102EIF2AK30.51801742
103PAK30.50110575
104CSNK2A10.49303498
105MOS0.46973212
106CDK10.46220843
107EPHA40.45347177
108MKNK10.44611277
109EPHA20.44521792
110CSNK2A20.43688443
111NLK0.43313442
112MAP3K100.42112965
113MAP3K50.41755613
114MARK20.41221288
115FGFR10.37936742
116ATR0.37432671
117GRK10.37368693
118DAPK30.37068287
119MAPK110.35846939
120STK240.35617207
121PRKD20.33847532
122FLT30.33531003
123LRRK20.29732224
124MAPK100.28955626
125MARK30.28933842
126MATK0.28410061
127TYRO30.27708839
128GRK50.27010233
129CSNK1G10.26194265
130PTK60.25559013
131SMG10.23235430
132TSSK60.22673779
133NUAK10.22517241
134CSNK1E0.20927260
135MTOR0.20510291
136MAP2K10.19200715
137EIF2AK20.18780791
138TLK10.18770794
139CSNK1A10.18280391
140TESK20.18245276
141GSK3B0.17852958
142SCYL20.17714344
143GSK3A0.17429873
144MAP4K20.17330835
145CCNB10.17000690
146ALK0.14578220
147FGR0.14240515
148SGK20.13042794
149MAPK140.12986772
150CSNK1G20.12981098
151MAP2K40.12376088
152NEK90.12084950
153MAP3K40.11927621

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.98235699
2Cell cycle_Homo sapiens_hsa041104.37462111
3RNA polymerase_Homo sapiens_hsa030204.23547075
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43841695
5Basal transcription factors_Homo sapiens_hsa030223.38946811
6RNA transport_Homo sapiens_hsa030133.25118602
7RNA degradation_Homo sapiens_hsa030183.02983757
8Fanconi anemia pathway_Homo sapiens_hsa034602.82882452
9Fat digestion and absorption_Homo sapiens_hsa049752.44534229
10Homologous recombination_Homo sapiens_hsa034402.37433604
11p53 signaling pathway_Homo sapiens_hsa041152.33301606
12DNA replication_Homo sapiens_hsa030302.30056410
13Oocyte meiosis_Homo sapiens_hsa041142.22858755
14Nucleotide excision repair_Homo sapiens_hsa034202.18501539
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.09007220
16Ribosome_Homo sapiens_hsa030102.05590048
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02139116
18Circadian rhythm_Homo sapiens_hsa047102.01562212
19Pyrimidine metabolism_Homo sapiens_hsa002402.00812964
20Galactose metabolism_Homo sapiens_hsa000522.00239743
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97727225
22Mismatch repair_Homo sapiens_hsa034301.96148525
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88479399
24Fructose and mannose metabolism_Homo sapiens_hsa000511.81188412
25Pentose phosphate pathway_Homo sapiens_hsa000301.79473536
26Base excision repair_Homo sapiens_hsa034101.74531956
27Renin-angiotensin system_Homo sapiens_hsa046141.72789933
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70637380
29Chemical carcinogenesis_Homo sapiens_hsa052041.69695370
30Spliceosome_Homo sapiens_hsa030401.66932855
31mRNA surveillance pathway_Homo sapiens_hsa030151.56822925
32Oxidative phosphorylation_Homo sapiens_hsa001901.56426919
33Ovarian steroidogenesis_Homo sapiens_hsa049131.55008006
34Fatty acid elongation_Homo sapiens_hsa000621.54969790
35Starch and sucrose metabolism_Homo sapiens_hsa005001.52860379
36Sulfur metabolism_Homo sapiens_hsa009201.52640881
37Caffeine metabolism_Homo sapiens_hsa002321.51946592
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51002160
39Linoleic acid metabolism_Homo sapiens_hsa005911.50672459
40Sulfur relay system_Homo sapiens_hsa041221.48407586
41Mineral absorption_Homo sapiens_hsa049781.47845653
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46491560
43Pyruvate metabolism_Homo sapiens_hsa006201.42945077
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41622197
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41147108
46Biosynthesis of amino acids_Homo sapiens_hsa012301.41017870
47Parkinsons disease_Homo sapiens_hsa050121.40568104
48Purine metabolism_Homo sapiens_hsa002301.36494854
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34303839
50One carbon pool by folate_Homo sapiens_hsa006701.31654319
51Folate biosynthesis_Homo sapiens_hsa007901.31634099
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30609909
53Glycerophospholipid metabolism_Homo sapiens_hsa005641.30383033
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.27916533
55Ether lipid metabolism_Homo sapiens_hsa005651.25730016
56Huntingtons disease_Homo sapiens_hsa050161.25085194
57Histidine metabolism_Homo sapiens_hsa003401.22887833
58Non-homologous end-joining_Homo sapiens_hsa034501.22154901
59Regulation of autophagy_Homo sapiens_hsa041401.19182587
60TGF-beta signaling pathway_Homo sapiens_hsa043501.17774232
61Primary bile acid biosynthesis_Homo sapiens_hsa001201.16126388
62Protein digestion and absorption_Homo sapiens_hsa049741.14217008
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.07261860
64Pancreatic cancer_Homo sapiens_hsa052121.05219581
65Fatty acid degradation_Homo sapiens_hsa000711.05113301
66Epstein-Barr virus infection_Homo sapiens_hsa051691.02823081
67Tryptophan metabolism_Homo sapiens_hsa003800.96975807
68Arginine biosynthesis_Homo sapiens_hsa002200.96818679
69Phenylalanine metabolism_Homo sapiens_hsa003600.96645606
70Renal cell carcinoma_Homo sapiens_hsa052110.95146124
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94645440
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88716203
73Propanoate metabolism_Homo sapiens_hsa006400.88129043
74MicroRNAs in cancer_Homo sapiens_hsa052060.87433333
75Choline metabolism in cancer_Homo sapiens_hsa052310.86672365
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85464452
77Alzheimers disease_Homo sapiens_hsa050100.82270742
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79238161
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.78961794
80Colorectal cancer_Homo sapiens_hsa052100.78882097
81Arginine and proline metabolism_Homo sapiens_hsa003300.77948881
82Peroxisome_Homo sapiens_hsa041460.77632694
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75529849
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74606167
85Prolactin signaling pathway_Homo sapiens_hsa049170.73662063
86FoxO signaling pathway_Homo sapiens_hsa040680.71141596
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70002420
88N-Glycan biosynthesis_Homo sapiens_hsa005100.69668436
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69570419
90Protein export_Homo sapiens_hsa030600.68436843
91Small cell lung cancer_Homo sapiens_hsa052220.67221047
92Fatty acid metabolism_Homo sapiens_hsa012120.66232867
93Tyrosine metabolism_Homo sapiens_hsa003500.66216157
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.65926022
95PPAR signaling pathway_Homo sapiens_hsa033200.65916749
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65440853
97GnRH signaling pathway_Homo sapiens_hsa049120.65316071
98Vitamin digestion and absorption_Homo sapiens_hsa049770.65174880
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64555214
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63978376
101mTOR signaling pathway_Homo sapiens_hsa041500.62690904
102Proteasome_Homo sapiens_hsa030500.62036714
103Herpes simplex infection_Homo sapiens_hsa051680.61452069
104Bile secretion_Homo sapiens_hsa049760.59833647
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59659561
106beta-Alanine metabolism_Homo sapiens_hsa004100.59372734
107Hippo signaling pathway_Homo sapiens_hsa043900.56818784
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56017373
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54962192
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51593702
111Endometrial cancer_Homo sapiens_hsa052130.51442038
112Adherens junction_Homo sapiens_hsa045200.51160912
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51119597
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50578104
115Inositol phosphate metabolism_Homo sapiens_hsa005620.49279199
116Viral carcinogenesis_Homo sapiens_hsa052030.49178291
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48834063
118Thyroid cancer_Homo sapiens_hsa052160.47762475
119Prostate cancer_Homo sapiens_hsa052150.45139540
120Arachidonic acid metabolism_Homo sapiens_hsa005900.44743958
121Dorso-ventral axis formation_Homo sapiens_hsa043200.43234244
122Hepatitis B_Homo sapiens_hsa051610.43056747
123VEGF signaling pathway_Homo sapiens_hsa043700.42380908
124Sphingolipid metabolism_Homo sapiens_hsa006000.40230918
125Notch signaling pathway_Homo sapiens_hsa043300.38768792
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38512693
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.36594306
128Bladder cancer_Homo sapiens_hsa052190.30132972
129Non-small cell lung cancer_Homo sapiens_hsa052230.26330904
130AMPK signaling pathway_Homo sapiens_hsa041520.23689883
131Steroid biosynthesis_Homo sapiens_hsa001000.21502134
132Glutathione metabolism_Homo sapiens_hsa004800.20387259
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.20059829
134HTLV-I infection_Homo sapiens_hsa051660.19814735
135Chronic myeloid leukemia_Homo sapiens_hsa052200.19615819
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19530127
137Tight junction_Homo sapiens_hsa045300.18078126
138Carbon metabolism_Homo sapiens_hsa012000.16723096
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15903536
140Glycerolipid metabolism_Homo sapiens_hsa005610.15020763
141Estrogen signaling pathway_Homo sapiens_hsa049150.14852562
142Metabolic pathways_Homo sapiens_hsa011000.13566356
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.12135135
144Retinol metabolism_Homo sapiens_hsa008300.11175176
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.09428099
146ErbB signaling pathway_Homo sapiens_hsa040120.09346443
147Melanoma_Homo sapiens_hsa052180.09052529
148Pathways in cancer_Homo sapiens_hsa052000.08603188
149Selenocompound metabolism_Homo sapiens_hsa004500.06618494
1502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.06523686
151Lysine degradation_Homo sapiens_hsa003100.06114008
152Other glycan degradation_Homo sapiens_hsa005110.06079322

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