TMEM97

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serine family amino acid biosynthetic process (GO:0009070)4.73527442
2intestinal cholesterol absorption (GO:0030299)4.65867644
3CENP-A containing nucleosome assembly (GO:0034080)4.52805651
4L-serine metabolic process (GO:0006563)4.43618380
5glycine metabolic process (GO:0006544)4.40456751
6establishment of integrated proviral latency (GO:0075713)4.32758544
7binding of sperm to zona pellucida (GO:0007339)3.83975988
8serine family amino acid metabolic process (GO:0009069)3.81871358
9nucleobase biosynthetic process (GO:0046112)3.79042629
10folic acid metabolic process (GO:0046655)3.77334907
11cysteine metabolic process (GO:0006534)3.73491763
12sperm-egg recognition (GO:0035036)3.72991359
13purine nucleobase biosynthetic process (GO:0009113)3.72302023
14DNA replication-independent nucleosome assembly (GO:0006336)3.71511013
15DNA replication-independent nucleosome organization (GO:0034724)3.71511013
16DNA deamination (GO:0045006)3.70093586
17piRNA metabolic process (GO:0034587)3.64996906
18mitotic sister chromatid segregation (GO:0000070)3.64731046
19folic acid-containing compound biosynthetic process (GO:0009396)3.64387886
20sister chromatid segregation (GO:0000819)3.53714845
21proline biosynthetic process (GO:0006561)3.53612879
22formation of translation preinitiation complex (GO:0001731)3.50608469
23L-phenylalanine metabolic process (GO:0006558)3.46258894
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.46258894
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45328272
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.41831117
27L-phenylalanine catabolic process (GO:0006559)3.41831117
28metaphase plate congression (GO:0051310)3.39424071
29mitotic recombination (GO:0006312)3.38383380
30fusion of sperm to egg plasma membrane (GO:0007342)3.37950248
31DNA ligation (GO:0006266)3.33689784
32kinetochore organization (GO:0051383)3.30692706
33heterochromatin organization (GO:0070828)3.28230703
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.27492359
35nuclear pore complex assembly (GO:0051292)3.24492342
36sperm motility (GO:0030317)3.24143980
37cell-cell recognition (GO:0009988)3.23848287
38protein retention in ER lumen (GO:0006621)3.23378818
39DNA strand elongation involved in DNA replication (GO:0006271)3.23037014
40tetrahydrofolate metabolic process (GO:0046653)3.22315705
41establishment of viral latency (GO:0019043)3.22070470
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.18594088
43mitotic chromosome condensation (GO:0007076)3.14315305
44serine family amino acid catabolic process (GO:0009071)3.12531261
45chaperone-mediated protein complex assembly (GO:0051131)3.11860661
46spindle checkpoint (GO:0031577)3.10237820
47DNA damage response, detection of DNA damage (GO:0042769)3.10004936
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.09088391
49one-carbon metabolic process (GO:0006730)3.08642799
50folic acid-containing compound metabolic process (GO:0006760)3.07440203
51sulfur amino acid biosynthetic process (GO:0000097)3.06499411
52DNA strand elongation (GO:0022616)3.04470889
53DNA strand renaturation (GO:0000733)3.04107868
54DNA replication-dependent nucleosome assembly (GO:0006335)3.03963778
55DNA replication-dependent nucleosome organization (GO:0034723)3.03963778
56synaptonemal complex assembly (GO:0007130)3.03611443
57negative regulation of chromosome segregation (GO:0051985)3.03289695
58kinetochore assembly (GO:0051382)3.01890800
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00477049
60negative regulation of mitotic sister chromatid separation (GO:2000816)3.00342196
61negative regulation of sister chromatid segregation (GO:0033046)3.00342196
62negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00342196
63negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00342196
64negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00342196
65pteridine-containing compound biosynthetic process (GO:0042559)3.00215219
66regulation of mitochondrial translation (GO:0070129)2.97594810
67ATP-dependent chromatin remodeling (GO:0043044)2.97093302
68mitotic spindle checkpoint (GO:0071174)2.96671178
69telomere maintenance via telomere lengthening (GO:0010833)2.95414428
70telomere maintenance via semi-conservative replication (GO:0032201)2.95232352
71sulfur amino acid catabolic process (GO:0000098)2.95008575
72synaptonemal complex organization (GO:0070193)2.94599835
73exocrine pancreas development (GO:0031017)2.94166090
74homocysteine metabolic process (GO:0050667)2.92773546
75replication fork processing (GO:0031297)2.92718621
76chaperone-mediated protein transport (GO:0072321)2.92183612
77male meiosis (GO:0007140)2.92066325
78DNA replication initiation (GO:0006270)2.91500597
79spliceosomal snRNP assembly (GO:0000387)2.91275953
80alpha-amino acid biosynthetic process (GO:1901607)2.90430722
81somatic hypermutation of immunoglobulin genes (GO:0016446)2.90382510
82somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90382510
83chromatin assembly or disassembly (GO:0006333)2.87603497
84energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87348704
85ATP synthesis coupled proton transport (GO:0015986)2.87348704
86double-strand break repair via nonhomologous end joining (GO:0006303)2.87098478
87non-recombinational repair (GO:0000726)2.87098478
88proline metabolic process (GO:0006560)2.87069299
89regulation of chromosome segregation (GO:0051983)2.86712630
90cholesterol biosynthetic process (GO:0006695)2.84347399
91ribosome assembly (GO:0042255)2.83936738
92spermatid development (GO:0007286)2.82453767
93negative regulation of DNA-dependent DNA replication (GO:2000104)2.81766757
94pteridine-containing compound metabolic process (GO:0042558)2.81615919
95aspartate family amino acid metabolic process (GO:0009066)2.81352718
96maturation of SSU-rRNA (GO:0030490)2.81207945
97DNA double-strand break processing (GO:0000729)2.80457833
98mitotic nuclear envelope disassembly (GO:0007077)2.78956027
99proteasome assembly (GO:0043248)2.78634495
100regulation of centriole replication (GO:0046599)2.78371223
101mitotic metaphase plate congression (GO:0007080)2.78339732
102digestion (GO:0007586)2.78167565
103regulation of mitotic metaphase/anaphase transition (GO:0030071)2.77972001
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77972001
105amino acid salvage (GO:0043102)2.77842090
106L-methionine salvage (GO:0071267)2.77842090
107L-methionine biosynthetic process (GO:0071265)2.77842090
108mitotic spindle assembly checkpoint (GO:0007094)2.77104778
109regulation of helicase activity (GO:0051095)2.75648597
110spindle assembly checkpoint (GO:0071173)2.74047209
111translational termination (GO:0006415)2.73374830
112aromatic amino acid family catabolic process (GO:0009074)2.73312965
113regulation of mitotic spindle checkpoint (GO:1903504)2.73007128
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.73007128
115mitotic G2/M transition checkpoint (GO:0044818)2.72553375
116cilium or flagellum-dependent cell motility (GO:0001539)2.72118585
117IMP metabolic process (GO:0046040)2.71683074
118ribosome biogenesis (GO:0042254)2.71423017
119DNA topological change (GO:0006265)2.71083473
120ribosomal large subunit biogenesis (GO:0042273)2.70271438
121glyoxylate metabolic process (GO:0046487)2.69749320
122regulation of mitotic sister chromatid separation (GO:0010965)2.69436701
123regulation of mitotic sister chromatid segregation (GO:0033047)2.69436701
124regulation of sister chromatid segregation (GO:0033045)2.69436701
125protein localization to chromosome, centromeric region (GO:0071459)2.69110925
126viral transcription (GO:0019083)2.67438304
127DNA replication checkpoint (GO:0000076)2.67001759
128rRNA modification (GO:0000154)2.66955113
129aspartate family amino acid biosynthetic process (GO:0009067)2.65438320
130establishment of chromosome localization (GO:0051303)2.64323381
131ribosomal small subunit assembly (GO:0000028)2.61752236
132chromosome segregation (GO:0007059)2.60480335
133IMP biosynthetic process (GO:0006188)2.60376426
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.60246817
135negative regulation of ligase activity (GO:0051352)2.60090105
136negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60090105
137SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.59677523
138protein localization to kinetochore (GO:0034501)2.59450610
139DNA methylation involved in gamete generation (GO:0043046)2.59342718
140telomere maintenance via recombination (GO:0000722)2.59026148
141sterol biosynthetic process (GO:0016126)2.58922385
142cotranslational protein targeting to membrane (GO:0006613)2.58796971
143regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.57810608
144anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57352172
145chromosome condensation (GO:0030261)2.56644111
146aspartate family amino acid catabolic process (GO:0009068)2.56219872
147negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55943883
148L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55417194
149male meiosis I (GO:0007141)2.55328447
150nuclear pore organization (GO:0006999)2.55083437
151ribonucleoprotein complex biogenesis (GO:0022613)2.54826173
152meiosis I (GO:0007127)2.54011361
153multicellular organism reproduction (GO:0032504)2.53727092
154histone exchange (GO:0043486)2.51522115
155nuclear envelope disassembly (GO:0051081)2.51505748
156membrane disassembly (GO:0030397)2.51505748
157cell wall macromolecule catabolic process (GO:0016998)2.50922496
158cell wall macromolecule metabolic process (GO:0044036)2.50922496
159positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50387830
160regulation of cellular amino acid metabolic process (GO:0006521)2.50385459
161chromatin remodeling at centromere (GO:0031055)2.48071713
162intestinal absorption (GO:0050892)2.47366050
163protein deneddylation (GO:0000338)2.46384955
164cellular modified amino acid catabolic process (GO:0042219)2.46159752
165pseudouridine synthesis (GO:0001522)2.45947940
166meiotic nuclear division (GO:0007126)2.45654194
167acrosome assembly (GO:0001675)2.44703194
168cellular amino acid biosynthetic process (GO:0008652)2.44681339
169branched-chain amino acid catabolic process (GO:0009083)2.44486844
170DNA unwinding involved in DNA replication (GO:0006268)2.44481058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.31691819
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.04503578
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.85488577
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50472853
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.46645062
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36463603
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04451431
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93054524
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87958894
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79961185
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.76103523
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.74319772
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.69926439
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57168221
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.51152475
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45784425
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45062558
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43656221
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.25965924
20AR_21909140_ChIP-Seq_LNCAP_Human2.13148030
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.09380541
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08599671
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07843657
24RXR_22158963_ChIP-Seq_LIVER_Mouse2.05332004
25* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.04044748
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01414779
27DCP1A_22483619_ChIP-Seq_HELA_Human2.01112335
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99008537
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97875570
30XRN2_22483619_ChIP-Seq_HELA_Human1.95937423
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94851961
32VDR_23849224_ChIP-Seq_CD4+_Human1.90986979
33* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90975892
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88420025
35GABP_19822575_ChIP-Seq_HepG2_Human1.87921756
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84998886
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82622053
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81545417
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75576810
40FOXP3_21729870_ChIP-Seq_TREG_Human1.72141903
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62098726
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60301449
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58555981
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.54546635
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53865494
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53420435
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.52760549
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52686504
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52333149
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.49368032
51* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45567563
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44705584
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44484133
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.44269394
55TTF2_22483619_ChIP-Seq_HELA_Human1.42866397
56* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42326161
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41394508
58KDM5A_27292631_Chip-Seq_BREAST_Human1.38150156
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37308986
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.36825905
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30022460
62* E2F1_21310950_ChIP-Seq_MCF-7_Human1.27179099
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.25983884
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25747861
65EWS_26573619_Chip-Seq_HEK293_Human1.24874811
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24656230
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22089059
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21729739
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19142894
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17592940
71FUS_26573619_Chip-Seq_HEK293_Human1.16744512
72* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16265285
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16056813
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12451961
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11584945
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11198774
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11132645
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08966112
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08949141
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07985982
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07336857
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06879126
83SOX17_20123909_ChIP-Seq_XEN_Mouse1.05693998
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04954047
85ELK1_19687146_ChIP-ChIP_HELA_Human1.04547757
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04168286
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03316779
88* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02764504
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02516848
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01465631
91IRF1_19129219_ChIP-ChIP_H3396_Human1.00964852
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97540119
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97478145
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97198048
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96998987
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96992462
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95320571
98ZNF274_21170338_ChIP-Seq_K562_Hela0.94152051
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.93433589
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93288847
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88281418
102RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88219741
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88200092
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86114205
105* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.83890857
106MYC_18940864_ChIP-ChIP_HL60_Human0.83850874
107* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83450683
108RARA_24833708_ChIP-Seq_LIVER_Mouse0.82902540
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82470435
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82424026
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81779820
112YY1_22570637_ChIP-Seq_MALME-3M_Human0.81743035
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81428702
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80711340
115CIITA_25753668_ChIP-Seq_RAJI_Human0.80350155
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79470216
117KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78705626
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78354630
119TFEB_21752829_ChIP-Seq_HELA_Human0.77275803
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76850562
121* FOXP1_21924763_ChIP-Seq_HESCs_Human0.76645294
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75903131
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.75791555
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.75791555
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.75791555
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75648347
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75097122
128CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74545703
129TCF3_18692474_ChIP-Seq_MESCs_Mouse0.73159436
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73014883
131SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.72020822
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.70728491
133IGF1R_20145208_ChIP-Seq_DFB_Human0.69512737
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.68871349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005365_abnormal_bile_salt4.71757050
2MP0005083_abnormal_biliary_tract4.49032326
3MP0002139_abnormal_hepatobiliary_system4.35563107
4MP0003806_abnormal_nucleotide_metabolis4.25677599
5MP0001666_abnormal_nutrient_absorption3.85880056
6MP0005085_abnormal_gallbladder_physiolo3.83690514
7MP0003693_abnormal_embryo_hatching3.83095706
8MP0005410_abnormal_fertilization3.79157756
9MP0005360_urolithiasis3.69012055
10MP0004957_abnormal_blastocyst_morpholog2.81167950
11MP0006292_abnormal_olfactory_placode2.75744630
12MP0010094_abnormal_chromosome_stability2.54438149
13MP0003111_abnormal_nucleus_morphology2.45040670
14MP0005220_abnormal_exocrine_pancreas2.41962476
15MP0002938_white_spotting2.33072090
16MP0003941_abnormal_skin_development2.31769179
17MP0010030_abnormal_orbit_morphology2.18568612
18MP0008875_abnormal_xenobiotic_pharmacok2.16778124
19MP0003077_abnormal_cell_cycle2.14129625
20MP0003868_abnormal_feces_composition2.09756701
21MP0000566_synostosis2.08465294
22MP0001929_abnormal_gametogenesis2.00337448
23MP0003186_abnormal_redox_activity1.99027762
24MP0003136_yellow_coat_color1.96106914
25MP0008057_abnormal_DNA_replication1.91590235
26MP0009840_abnormal_foam_cell1.91118061
27MP0008058_abnormal_DNA_repair1.90820043
28MP0005332_abnormal_amino_acid1.84600745
29MP0003718_maternal_effect1.84509090
30MP0003121_genomic_imprinting1.83156314
31MP0003937_abnormal_limbs/digits/tail_de1.77852175
32MP0001529_abnormal_vocalization1.74540539
33MP0001764_abnormal_homeostasis1.73537482
34MP0008877_abnormal_DNA_methylation1.71326586
35MP0003567_abnormal_fetal_cardiomyocyte1.70238232
36MP0003698_abnormal_male_reproductive1.67189094
37MP0000537_abnormal_urethra_morphology1.65354821
38MP0010329_abnormal_lipoprotein_level1.64590637
39MP0003122_maternal_imprinting1.64520640
40MP0003315_abnormal_perineum_morphology1.64283055
41MP0002697_abnormal_eye_size1.61185282
42MP0002210_abnormal_sex_determination1.59253520
43MP0005084_abnormal_gallbladder_morpholo1.58664746
44MP0009379_abnormal_foot_pigmentation1.57134531
45MP0006036_abnormal_mitochondrial_physio1.53131421
46MP0005451_abnormal_body_composition1.51833445
47MP0003119_abnormal_digestive_system1.49052027
48MP0001730_embryonic_growth_arrest1.48017171
49MP0001145_abnormal_male_reproductive1.47967523
50MP0008789_abnormal_olfactory_epithelium1.45586236
51MP0001286_abnormal_eye_development1.44652900
52MP0003252_abnormal_bile_duct1.43970129
53MP0003123_paternal_imprinting1.43829809
54MP0002233_abnormal_nose_morphology1.41880680
55MP0008932_abnormal_embryonic_tissue1.40829098
56MP0008007_abnormal_cellular_replicative1.34400780
57MP0000653_abnormal_sex_gland1.30346644
58MP0000049_abnormal_middle_ear1.28046514
59MP0003786_premature_aging1.27891209
60MP0003656_abnormal_erythrocyte_physiolo1.27295649
61MP0005319_abnormal_enzyme/_coenzyme1.24390772
62MP0000609_abnormal_liver_physiology1.22188860
63MP0004264_abnormal_extraembryonic_tissu1.21231955
64MP0003011_delayed_dark_adaptation1.21095075
65MP0003705_abnormal_hypodermis_morpholog1.21047131
66MP0005394_taste/olfaction_phenotype1.20889221
67MP0005499_abnormal_olfactory_system1.20889221
68MP0005408_hypopigmentation1.18906407
69MP0000372_irregular_coat_pigmentation1.18386857
70MP0004133_heterotaxia1.16894378
71MP0002111_abnormal_tail_morphology1.15333166
72MP0006072_abnormal_retinal_apoptosis1.14893470
73MP0002118_abnormal_lipid_homeostasis1.13272896
74MP0000490_abnormal_crypts_of1.10851352
75MP0000598_abnormal_liver_morphology1.10137699
76MP0002161_abnormal_fertility/fecundity1.08231024
77MP0006035_abnormal_mitochondrial_morpho1.07497919
78MP0009697_abnormal_copulation1.06555705
79MP0003861_abnormal_nervous_system1.05275634
80MP0002160_abnormal_reproductive_system1.04481697
81MP0008995_early_reproductive_senescence1.04264458
82MP0002102_abnormal_ear_morphology1.03960824
83MP0009703_decreased_birth_body1.03956730
84MP0000350_abnormal_cell_proliferation1.03776751
85MP0002092_abnormal_eye_morphology1.03621580
86MP0000358_abnormal_cell_content/1.01160790
87MP0003755_abnormal_palate_morphology1.00634181
88MP0001346_abnormal_lacrimal_gland0.99148580
89MP0000631_abnormal_neuroendocrine_gland0.98649922
90MP0004019_abnormal_vitamin_homeostasis0.98640322
91MP0002751_abnormal_autonomic_nervous0.97878228
92MP0001672_abnormal_embryogenesis/_devel0.97180302
93MP0005380_embryogenesis_phenotype0.97180302
94MP0003938_abnormal_ear_development0.95181496
95MP0005391_vision/eye_phenotype0.92699842
96MP0002080_prenatal_lethality0.92436763
97MP0000647_abnormal_sebaceous_gland0.92396113
98MP0003195_calcinosis0.91218226
99MP0001697_abnormal_embryo_size0.89555073
100MP0003942_abnormal_urinary_system0.89514122
101MP0002132_abnormal_respiratory_system0.88192627
102MP0009643_abnormal_urine_homeostasis0.88147841
103MP0000428_abnormal_craniofacial_morphol0.86339479
104MP0003984_embryonic_growth_retardation0.85114367
105MP0000778_abnormal_nervous_system0.83687904
106MP0001188_hyperpigmentation0.83347950
107MP0002088_abnormal_embryonic_growth/wei0.83156713
108MP0009672_abnormal_birth_weight0.82019764
109MP0005647_abnormal_sex_gland0.80516990
110MP0005670_abnormal_white_adipose0.80229832
111MP0005187_abnormal_penis_morphology0.80144600
112MP0001299_abnormal_eye_distance/0.80141879
113MP0006054_spinal_hemorrhage0.79910551
114MP0005266_abnormal_metabolism0.78566747
115MP0002234_abnormal_pharynx_morphology0.78376508
116MP0002282_abnormal_trachea_morphology0.77180174
117MP0005636_abnormal_mineral_homeostasis0.77159865
118MP0003191_abnormal_cellular_cholesterol0.76362390
119MP0000313_abnormal_cell_death0.74555884
120MP0003935_abnormal_craniofacial_develop0.74449282
121MP0003878_abnormal_ear_physiology0.72341349
122MP0005377_hearing/vestibular/ear_phenot0.72341349
123MP0009333_abnormal_splenocyte_physiolog0.72183893
124MP0004197_abnormal_fetal_growth/weight/0.72134728
125MP0000579_abnormal_nail_morphology0.71852209
126MP0005253_abnormal_eye_physiology0.71387073
127MP0002090_abnormal_vision0.71158726
128MP0003385_abnormal_body_wall0.70504705
129MP0002019_abnormal_tumor_incidence0.70044766
130MP0000432_abnormal_head_morphology0.68862131
131MP0005389_reproductive_system_phenotype0.68040315
132MP0005376_homeostasis/metabolism_phenot0.66520039
133MP0001177_atelectasis0.65338814
134MP0001485_abnormal_pinna_reflex0.65303575
135MP0010352_gastrointestinal_tract_polyps0.65277635
136MP0010307_abnormal_tumor_latency0.64894994
137MP0002396_abnormal_hematopoietic_system0.64610242
138MP0005395_other_phenotype0.63488340
139MP0002086_abnormal_extraembryonic_tissu0.62156161
140MP0005584_abnormal_enzyme/coenzyme_acti0.61373155
141MP0002085_abnormal_embryonic_tissue0.61121166
142MP0001119_abnormal_female_reproductive0.59949957
143MP0004233_abnormal_muscle_weight0.59839714
144MP0003959_abnormal_lean_body0.59650147
145MP0001661_extended_life_span0.56765450
146MP0009763_increased_sensitivity_to0.54548848
147MP0003699_abnormal_female_reproductive0.53028663
148MP0003890_abnormal_embryonic-extraembry0.52968537
149MP0008469_abnormal_protein_level0.52756055
150MP0002084_abnormal_developmental_patter0.50499021
151MP0009053_abnormal_anal_canal0.49246382
152MP0003638_abnormal_response/metabolism_0.48881551
153MP0001293_anophthalmia0.48873966
154MP0001243_abnormal_dermal_layer0.48318619
155MP0003221_abnormal_cardiomyocyte_apopto0.47984932
156MP0009765_abnormal_xenobiotic_induced0.47137775

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22211545
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.21284152
3Hypobetalipoproteinemia (HP:0003563)4.06129662
4Chromsome breakage (HP:0040012)3.96556279
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.74088781
6Intrahepatic cholestasis (HP:0001406)3.65031373
7Steatorrhea (HP:0002570)3.64711336
8Carpal bone hypoplasia (HP:0001498)3.60606976
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.60356736
10Fat malabsorption (HP:0002630)3.58368658
11Hyperglycinemia (HP:0002154)3.51122974
12Meckel diverticulum (HP:0002245)3.38882874
13Abnormality of pyrimidine metabolism (HP:0004353)3.35093155
14Abnormality of methionine metabolism (HP:0010901)3.26564792
15Abnormality of the intrinsic pathway (HP:0010989)3.23558647
16Abnormality of the ileum (HP:0001549)3.22218594
17Colon cancer (HP:0003003)3.22095983
18Abnormality of the labia minora (HP:0012880)3.14993967
19Abnormal lung lobation (HP:0002101)3.11451591
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.08140269
21Abnormality of cells of the erythroid lineage (HP:0012130)3.07988424
22Oral leukoplakia (HP:0002745)3.07166766
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.05470805
24Deep venous thrombosis (HP:0002625)3.04297948
25Abnormal number of erythroid precursors (HP:0012131)3.02801165
26Abnormality of glycine metabolism (HP:0010895)2.95223521
27Abnormality of serine family amino acid metabolism (HP:0010894)2.95223521
28Hyperglycinuria (HP:0003108)2.93131435
29Abnormality of the anterior horn cell (HP:0006802)2.90601447
30Degeneration of anterior horn cells (HP:0002398)2.90601447
31Hyperammonemia (HP:0001987)2.89445754
32Absent/shortened dynein arms (HP:0200106)2.89195406
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.89195406
34Abnormality of chromosome stability (HP:0003220)2.87431154
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.84387188
36Megaloblastic anemia (HP:0001889)2.82357829
37Multiple enchondromatosis (HP:0005701)2.80910510
38Hypolipoproteinemia (HP:0010981)2.75011389
39Prolonged partial thromboplastin time (HP:0003645)2.73212886
40Impulsivity (HP:0100710)2.70209491
41Abnormal spermatogenesis (HP:0008669)2.66601276
42Abnormality of the preputium (HP:0100587)2.66327182
43Xanthomatosis (HP:0000991)2.65371715
44Abnormality of serum amino acid levels (HP:0003112)2.64856670
45Irregular epiphyses (HP:0010582)2.60722381
46Reduced antithrombin III activity (HP:0001976)2.54007183
47Septo-optic dysplasia (HP:0100842)2.52770661
48Increased serum pyruvate (HP:0003542)2.51749037
49Abnormality of glycolysis (HP:0004366)2.51749037
50Nephroblastoma (Wilms tumor) (HP:0002667)2.45617346
51Cerebral hypomyelination (HP:0006808)2.45174457
52Ketosis (HP:0001946)2.45089457
53Gout (HP:0001997)2.44703688
54Triphalangeal thumb (HP:0001199)2.43916068
55Bifid tongue (HP:0010297)2.42097358
56Chronic bronchitis (HP:0004469)2.41792029
57Cerebral edema (HP:0002181)2.41541575
58Abnormality of the common coagulation pathway (HP:0010990)2.37989298
59Lethargy (HP:0001254)2.36382983
60Acute necrotizing encephalopathy (HP:0006965)2.36293362
61Increased hepatocellular lipid droplets (HP:0006565)2.36064381
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.35412816
63Birth length less than 3rd percentile (HP:0003561)2.35182270
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.34440066
65Small intestinal stenosis (HP:0012848)2.32043670
66Duodenal stenosis (HP:0100867)2.32043670
67Embryonal renal neoplasm (HP:0011794)2.31661114
68Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28360053
69Dicarboxylic aciduria (HP:0003215)2.27304142
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27304142
71Increased nuchal translucency (HP:0010880)2.26430701
72Reticulocytopenia (HP:0001896)2.26313214
73Breast hypoplasia (HP:0003187)2.26243439
74Abnormality of fatty-acid metabolism (HP:0004359)2.26183995
75Abnormality of the duodenum (HP:0002246)2.24534573
76Rhinitis (HP:0012384)2.23910095
77Hypoglycemic coma (HP:0001325)2.23667008
78Abnormal respiratory epithelium morphology (HP:0012253)2.23104424
79Abnormal respiratory motile cilium morphology (HP:0005938)2.23104424
80Macrocytic anemia (HP:0001972)2.22576838
81Abnormal cartilage morphology (HP:0002763)2.21500689
82Cortical dysplasia (HP:0002539)2.20841096
83Absent radius (HP:0003974)2.20771646
84Hyperlipoproteinemia (HP:0010980)2.20568627
85Rough bone trabeculation (HP:0100670)2.19545596
86Hypoplastic pelvis (HP:0008839)2.18679411
87Horseshoe kidney (HP:0000085)2.16442506
88Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15815785
89Lipid accumulation in hepatocytes (HP:0006561)2.15439712
90Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13458423
91Secondary amenorrhea (HP:0000869)2.12662823
92Abnormality of the carotid arteries (HP:0005344)2.11518317
93Progressive muscle weakness (HP:0003323)2.11217322
94Aplasia involving forearm bones (HP:0009822)2.09311112
95Absent forearm bone (HP:0003953)2.09311112
96Ectopic kidney (HP:0000086)2.09170060
97Abnormal mitochondria in muscle tissue (HP:0008316)2.08007147
98Bilateral microphthalmos (HP:0007633)2.04951036
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03757327
100Absent epiphyses (HP:0010577)2.03757327
101Abnormal tarsal ossification (HP:0008369)2.03081578
102Hyperbilirubinemia (HP:0002904)2.01238384
103Abnormality of nucleobase metabolism (HP:0010932)2.01191733
104Anophthalmia (HP:0000528)2.00825050
105Infertility (HP:0000789)2.00792015
106Pancytopenia (HP:0001876)2.00669632
107Abnormality of subcutaneous fat tissue (HP:0001001)2.00098984
108Microretrognathia (HP:0000308)1.99940700
109Abnormal respiratory motile cilium physiology (HP:0012261)1.99668019
110Aplastic anemia (HP:0001915)1.98803014
111Acute encephalopathy (HP:0006846)1.98592875
112Absent septum pellucidum (HP:0001331)1.95895109
113Selective tooth agenesis (HP:0001592)1.95875530
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.95415593
115Hepatic necrosis (HP:0002605)1.94900217
116Opisthotonus (HP:0002179)1.94770235
117Increased serum lactate (HP:0002151)1.93775197
118Hypoalphalipoproteinemia (HP:0003233)1.92968790
119Abnormal number of incisors (HP:0011064)1.92279438
120Type I transferrin isoform profile (HP:0003642)1.91019347
121Small epiphyses (HP:0010585)1.90950010
122Hypoplasia of the pons (HP:0012110)1.90409928
123Hemivertebrae (HP:0002937)1.90263299
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89766318
125Abnormal protein N-linked glycosylation (HP:0012347)1.89766318
126Abnormal protein glycosylation (HP:0012346)1.89766318
127Abnormal glycosylation (HP:0012345)1.89766318
128Facial cleft (HP:0002006)1.89207050
129Azoospermia (HP:0000027)1.88851129
130Supernumerary spleens (HP:0009799)1.88622136
131Esophageal atresia (HP:0002032)1.88619938
132Premature ovarian failure (HP:0008209)1.88592139
133Duplication of thumb phalanx (HP:0009942)1.87440269
134CNS demyelination (HP:0007305)1.84535052
135Upper motor neuron abnormality (HP:0002127)1.83924910
136Increased CSF lactate (HP:0002490)1.83479253
137Intestinal atresia (HP:0011100)1.83464431
138Sloping forehead (HP:0000340)1.83227672
139Abnormality of the pons (HP:0007361)1.82561048
140Proximal tubulopathy (HP:0000114)1.82066564
141Microvesicular hepatic steatosis (HP:0001414)1.81935423
142Nasal polyposis (HP:0100582)1.81763759
143Pancreatitis (HP:0001733)1.81692731
144Nausea (HP:0002018)1.81032174
145Brushfield spots (HP:0001088)1.80929188
146Trismus (HP:0000211)1.80545956
147Short thumb (HP:0009778)1.80131736
148Mitochondrial inheritance (HP:0001427)1.79458042
149Pancreatic islet-cell hyperplasia (HP:0004510)1.78679658
150Ependymoma (HP:0002888)1.77912240
151Abnormality of the septum pellucidum (HP:0007375)1.77842728
152Hepatoblastoma (HP:0002884)1.77710046
153Progressive macrocephaly (HP:0004481)1.75556551
154Rhabdomyosarcoma (HP:0002859)1.75384208
155Overlapping toe (HP:0001845)1.74753335
156Choanal atresia (HP:0000453)1.71932610
157Medulloblastoma (HP:0002885)1.71785454
158Absent thumb (HP:0009777)1.70748890
159Volvulus (HP:0002580)1.69604533
160Myelomeningocele (HP:0002475)1.68868769
161Stenosis of the external auditory canal (HP:0000402)1.65651672
162Patellar aplasia (HP:0006443)1.64311946
163Myelodysplasia (HP:0002863)1.63787266
164Gastrointestinal atresia (HP:0002589)1.63519606
165Facial hemangioma (HP:0000329)1.60919874
166Abnormal sex determination (HP:0012244)1.57310511
167Sex reversal (HP:0012245)1.57310511
168Glioma (HP:0009733)1.57011623
169Abnormality of cochlea (HP:0000375)1.56110255
170Embryonal neoplasm (HP:0002898)1.55575560
171Preaxial hand polydactyly (HP:0001177)1.54609913
172Bicornuate uterus (HP:0000813)1.53550162
173High anterior hairline (HP:0009890)1.53538175
174Microglossia (HP:0000171)1.53244827
175Renal agenesis (HP:0000104)1.53057131
176Aplasia/Hypoplasia of the patella (HP:0006498)1.51547877
177Hyperinsulinemic hypoglycemia (HP:0000825)1.51295895
178Renal hypoplasia (HP:0000089)1.51173132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.54129302
2BUB14.04343136
3PDK43.85087353
4PDK33.85087353
5WEE13.61257024
6VRK23.40458382
7EIF2AK13.02938990
8EIF2AK32.96306258
9TESK12.82278959
10CDC72.74672475
11PDK22.60893279
12NME22.43380354
13NEK22.40156877
14STK162.31088170
15MKNK22.15926947
16TAF12.12996192
17TTK2.04938714
18BRSK21.89601335
19PLK41.82410583
20TESK21.82138957
21ERN11.79241535
22ACVR1B1.68165598
23TRIM281.66997749
24NUAK11.63694454
25NEK11.59037162
26PLK11.53134302
27WNK31.51351478
28TNIK1.45871732
29TSSK61.43224120
30SRPK11.40090377
31VRK11.33011633
32PASK1.30761833
33BMPR1B1.25078692
34CCNB11.23844112
35AURKB1.22258332
36PKN21.21637125
37DYRK21.20865036
38MAP3K81.20426906
39CHEK21.10705110
40STK38L1.09636490
41MST41.09392628
42DYRK31.08660071
43EPHA21.06143031
44BRSK11.06001681
45AURKA1.05910102
46ATR1.04783609
47RPS6KB21.03876783
48PLK31.02420030
49SCYL21.01845465
50CDK41.01346475
51MAP2K21.00676318
52CDK71.00618717
53PIM21.00280076
54BRAF0.95810640
55RPS6KA40.91784202
56CSNK1G10.90877133
57NME10.90192321
58EEF2K0.87821065
59PBK0.87736310
60CHEK10.85551037
61BCR0.85193733
62ICK0.84733857
63STK30.84021200
64PLK20.83443089
65MAP3K30.81301211
66STK100.79870291
67CDK80.76389087
68CDK190.74976485
69CSNK1G30.73676278
70FLT30.73096413
71TRIB30.71655970
72MAP3K110.71255492
73FGFR10.71237118
74INSRR0.70497463
75PAK10.68591475
76PAK20.67656835
77CSNK2A10.65620809
78PAK40.65169428
79CSNK1G20.64917580
80ABL20.64758893
81KDR0.64734501
82TLK10.64117472
83MAP2K30.63909849
84EPHA40.63559794
85MKNK10.61017730
86FGFR20.60428171
87CSNK1A1L0.60241226
88BRD40.57737970
89CSNK2A20.57209750
90PIK3CG0.56311885
91CASK0.55076600
92PRKD30.54433978
93PINK10.54235394
94CAMK1G0.53553860
95ATM0.53104753
96CAMK1D0.52824758
97CDK30.51616076
98ZAP700.51535875
99SMG10.50994427
100STK40.50746413
101MAP4K20.49625293
102MAP3K40.49581010
103PNCK0.48768546
104MAP2K60.47119966
105PIM10.46653611
106EIF2AK20.46324804
107PRKDC0.46101813
108CDK20.45800357
109ERBB30.45106584
110MTOR0.44047929
111LRRK20.44040334
112MAPKAPK30.43678575
113LATS20.43297917
114WNK40.42126457
115TAOK20.42034377
116EPHB20.40863759
117PRKCI0.40828883
118ALK0.40771287
119MAP3K100.39662752
120ZAK0.39408946
121CDK180.38610636
122CDK11A0.37794705
123PRKCG0.36634222
124CDK150.36081108
125CLK10.36024536
126MAPK110.33393393
127CDK10.33019257
128MAPKAPK50.32981081
129ERBB40.32738093
130MET0.32734882
131IRAK30.31176471
132TGFBR10.29245396
133DYRK1B0.28338017
134STK390.28146178
135CDK60.27458521
136MST1R0.25992001
137NEK90.25180670
138CSNK1E0.24256888
139MELK0.23391809
140LATS10.20830298
141RPS6KB10.20448592

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62350155
2DNA replication_Homo sapiens_hsa030302.61930788
3Proteasome_Homo sapiens_hsa030502.47240753
4One carbon pool by folate_Homo sapiens_hsa006702.40761009
5Vitamin B6 metabolism_Homo sapiens_hsa007502.30712533
6Fat digestion and absorption_Homo sapiens_hsa049752.22504299
7Selenocompound metabolism_Homo sapiens_hsa004502.13752700
8Folate biosynthesis_Homo sapiens_hsa007902.12765065
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08566638
10Mismatch repair_Homo sapiens_hsa034302.03592896
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02847399
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.93356578
13Cysteine and methionine metabolism_Homo sapiens_hsa002701.92279976
14Ribosome_Homo sapiens_hsa030101.92206432
15Biosynthesis of amino acids_Homo sapiens_hsa012301.82043900
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81065934
17RNA polymerase_Homo sapiens_hsa030201.78828996
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.78632589
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74106708
20Propanoate metabolism_Homo sapiens_hsa006401.73384121
21Pyrimidine metabolism_Homo sapiens_hsa002401.72474000
22RNA transport_Homo sapiens_hsa030131.71111289
23Protein export_Homo sapiens_hsa030601.60050894
24Pyruvate metabolism_Homo sapiens_hsa006201.58620256
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55068165
26Steroid biosynthesis_Homo sapiens_hsa001001.53995989
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.50853078
28Pentose phosphate pathway_Homo sapiens_hsa000301.46481188
29Homologous recombination_Homo sapiens_hsa034401.44728133
30Carbon metabolism_Homo sapiens_hsa012001.44294734
31Base excision repair_Homo sapiens_hsa034101.44147685
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42533428
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41988256
34Nucleotide excision repair_Homo sapiens_hsa034201.39758436
35Glutathione metabolism_Homo sapiens_hsa004801.37891407
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37889499
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37069048
38Fatty acid degradation_Homo sapiens_hsa000711.32577204
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31970469
40Sulfur relay system_Homo sapiens_hsa041221.30138572
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27813144
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27314303
43Spliceosome_Homo sapiens_hsa030401.27238721
44Arginine biosynthesis_Homo sapiens_hsa002201.22203509
45Glycerolipid metabolism_Homo sapiens_hsa005611.20382676
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17001038
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16828626
48Tryptophan metabolism_Homo sapiens_hsa003801.14177292
49Pancreatic secretion_Homo sapiens_hsa049721.12908374
50Vitamin digestion and absorption_Homo sapiens_hsa049771.11905851
51Arginine and proline metabolism_Homo sapiens_hsa003301.11782472
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10895553
53Chemical carcinogenesis_Homo sapiens_hsa052041.08974013
54Protein digestion and absorption_Homo sapiens_hsa049741.06925638
55Peroxisome_Homo sapiens_hsa041461.05636245
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04786730
57Basal transcription factors_Homo sapiens_hsa030221.04556186
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02992033
59Fatty acid metabolism_Homo sapiens_hsa012121.00274718
60Cell cycle_Homo sapiens_hsa041100.99407318
61Fanconi anemia pathway_Homo sapiens_hsa034600.97394260
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96894794
63Nitrogen metabolism_Homo sapiens_hsa009100.96326158
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95976953
65Basal cell carcinoma_Homo sapiens_hsa052170.95557991
66beta-Alanine metabolism_Homo sapiens_hsa004100.94617505
67Fructose and mannose metabolism_Homo sapiens_hsa000510.94257265
68Linoleic acid metabolism_Homo sapiens_hsa005910.93730900
69Alzheimers disease_Homo sapiens_hsa050100.92635186
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.92513738
71Fatty acid elongation_Homo sapiens_hsa000620.91079352
72Complement and coagulation cascades_Homo sapiens_hsa046100.89770157
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87350201
74Purine metabolism_Homo sapiens_hsa002300.85908887
75Histidine metabolism_Homo sapiens_hsa003400.85815004
76Oocyte meiosis_Homo sapiens_hsa041140.81771224
77Retinol metabolism_Homo sapiens_hsa008300.81101404
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78848229
79Metabolic pathways_Homo sapiens_hsa011000.78225034
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76424632
81RNA degradation_Homo sapiens_hsa030180.75497998
82Sulfur metabolism_Homo sapiens_hsa009200.74417025
83Non-homologous end-joining_Homo sapiens_hsa034500.71455203
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.68219905
85Hedgehog signaling pathway_Homo sapiens_hsa043400.68133239
86Butanoate metabolism_Homo sapiens_hsa006500.67404798
87PPAR signaling pathway_Homo sapiens_hsa033200.67248068
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65402229
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65285665
90N-Glycan biosynthesis_Homo sapiens_hsa005100.63965801
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63756909
92Starch and sucrose metabolism_Homo sapiens_hsa005000.63510085
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63390297
94Phenylalanine metabolism_Homo sapiens_hsa003600.61693123
95Renin-angiotensin system_Homo sapiens_hsa046140.60719506
96Hippo signaling pathway_Homo sapiens_hsa043900.58130854
97Lysine degradation_Homo sapiens_hsa003100.55869696
98Huntingtons disease_Homo sapiens_hsa050160.55342126
99Systemic lupus erythematosus_Homo sapiens_hsa053220.53111796
100Galactose metabolism_Homo sapiens_hsa000520.51445312
101Tyrosine metabolism_Homo sapiens_hsa003500.50360602
102Cardiac muscle contraction_Homo sapiens_hsa042600.48772461
103TGF-beta signaling pathway_Homo sapiens_hsa043500.48531327
104p53 signaling pathway_Homo sapiens_hsa041150.48389132
105Caffeine metabolism_Homo sapiens_hsa002320.48352562
106Wnt signaling pathway_Homo sapiens_hsa043100.47677669
107Parkinsons disease_Homo sapiens_hsa050120.47120513
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46150500
109Arachidonic acid metabolism_Homo sapiens_hsa005900.45702878
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40998665
111Oxidative phosphorylation_Homo sapiens_hsa001900.40581685
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39813290
113mRNA surveillance pathway_Homo sapiens_hsa030150.38493079
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38291789
115Epstein-Barr virus infection_Homo sapiens_hsa051690.33582457
116Thyroid cancer_Homo sapiens_hsa052160.21737573
117Alcoholism_Homo sapiens_hsa050340.19064011
118Adherens junction_Homo sapiens_hsa045200.19047388

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