TMEM98

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.31039973
2axon ensheathment in central nervous system (GO:0032291)7.31039973
3proline biosynthetic process (GO:0006561)6.03571093
4proline metabolic process (GO:0006560)4.53540945
5fatty acid elongation (GO:0030497)4.46892794
6myelin maintenance (GO:0043217)4.18198295
7ensheathment of neurons (GO:0007272)4.10788148
8axon ensheathment (GO:0008366)4.10788148
9myelination (GO:0042552)3.94168393
10establishment of apical/basal cell polarity (GO:0035089)3.78260937
11neuron projection extension involved in neuron projection guidance (GO:1902284)3.65293330
12axon extension involved in axon guidance (GO:0048846)3.65293330
13cholesterol biosynthetic process (GO:0006695)3.56762779
14virion attachment to host cell (GO:0019062)3.55678842
15adhesion of symbiont to host cell (GO:0044650)3.55678842
16DNA deamination (GO:0045006)3.46704142
17vitamin A metabolic process (GO:0006776)3.46485717
18lateral sprouting from an epithelium (GO:0060601)3.43215623
19transcription from mitochondrial promoter (GO:0006390)3.42361431
20protein retention in ER lumen (GO:0006621)3.40517942
21negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.30035401
22negative regulation of chondrocyte differentiation (GO:0032331)3.21430767
23paraxial mesoderm development (GO:0048339)3.18482395
24somite development (GO:0061053)3.18215116
25asymmetric protein localization (GO:0008105)3.13230392
26intestinal cholesterol absorption (GO:0030299)3.12150159
27sterol biosynthetic process (GO:0016126)3.09215031
28regulation of non-canonical Wnt signaling pathway (GO:2000050)3.08681341
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06624447
30regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.03998709
31actin filament depolymerization (GO:0030042)3.00645698
32regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.98895390
33enteric nervous system development (GO:0048484)2.96999967
34positive regulation of actin filament depolymerization (GO:0030836)2.95882470
35heme transport (GO:0015886)2.95765564
36establishment or maintenance of monopolar cell polarity (GO:0061339)2.94142957
37establishment of monopolar cell polarity (GO:0061162)2.94142957
38protein heterotrimerization (GO:0070208)2.93559050
39G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.93317114
40mitotic nuclear envelope reassembly (GO:0007084)2.91392436
41nuclear envelope reassembly (GO:0031468)2.91392436
42embryonic camera-type eye development (GO:0031076)2.88168054
43adhesion of symbiont to host (GO:0044406)2.88039592
44oligodendrocyte differentiation (GO:0048709)2.86374957
45positive regulation of gastrulation (GO:2000543)2.86366344
46oxidative demethylation (GO:0070989)2.83554932
47renal filtration (GO:0097205)2.82998152
48outer ear morphogenesis (GO:0042473)2.82970099
49lung-associated mesenchyme development (GO:0060484)2.78436257
50glomerular filtration (GO:0003094)2.75772829
51anterior/posterior axis specification, embryo (GO:0008595)2.75130044
52peripheral nervous system axon ensheathment (GO:0032292)2.74182132
53myelination in peripheral nervous system (GO:0022011)2.74182132
54intraciliary transport (GO:0042073)2.73114833
55negative regulation of cartilage development (GO:0061037)2.72475599
56negative regulation of axon guidance (GO:1902668)2.72294020
57positive regulation of oligodendrocyte differentiation (GO:0048714)2.71124402
58protein neddylation (GO:0045116)2.70543507
59mesenchymal cell proliferation (GO:0010463)2.67319277
60apical protein localization (GO:0045176)2.67003139
61negative regulation of JAK-STAT cascade (GO:0046426)2.65605715
62negative chemotaxis (GO:0050919)2.63648728
63mesodermal cell differentiation (GO:0048333)2.62302712
64notochord development (GO:0030903)2.61942899
65negative regulation of epithelial to mesenchymal transition (GO:0010719)2.61557736
66apoptotic process involved in morphogenesis (GO:0060561)2.59420332
67negative regulation of cell cycle arrest (GO:0071157)2.58092648
68creatine metabolic process (GO:0006600)2.55907166
69astrocyte development (GO:0014002)2.55345725
70bone trabecula formation (GO:0060346)2.54601675
71glutamine family amino acid biosynthetic process (GO:0009084)2.54483549
72long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.54295829
73fatty-acyl-CoA biosynthetic process (GO:0046949)2.54286894
74digestive tract morphogenesis (GO:0048546)2.54238308
75artery development (GO:0060840)2.53365037
76chromatin remodeling at centromere (GO:0031055)2.51911500
77calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.50753554
78presynaptic membrane assembly (GO:0097105)2.50328822
79cullin deneddylation (GO:0010388)2.49298792
80prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.47998153
81retinal ganglion cell axon guidance (GO:0031290)2.47994192
82positive regulation of pseudopodium assembly (GO:0031274)2.47365037
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46766924
84membrane tubulation (GO:0097320)2.46527125
85limb bud formation (GO:0060174)2.46364772
86mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.45845420
87GDP-mannose metabolic process (GO:0019673)2.42642299
88convergent extension (GO:0060026)2.42314149
89very-low-density lipoprotein particle assembly (GO:0034379)2.42310778
90epithelial cilium movement (GO:0003351)2.41969033
91glomerular basement membrane development (GO:0032836)2.41185815
92otic vesicle formation (GO:0030916)2.40527920
93positive regulation of smoothened signaling pathway (GO:0045880)2.40393019
94nucleotide transmembrane transport (GO:1901679)2.39852107
95amyloid precursor protein catabolic process (GO:0042987)2.39395071
96regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.38834865
97establishment or maintenance of bipolar cell polarity (GO:0061245)2.38797040
98establishment or maintenance of apical/basal cell polarity (GO:0035088)2.38797040
99positive regulation of developmental pigmentation (GO:0048087)2.38353106
100extracellular matrix assembly (GO:0085029)2.37822401
101response to lead ion (GO:0010288)2.37754566
102short-term memory (GO:0007614)2.37410762
103negative regulation of protein localization to cell surface (GO:2000009)2.37297667
104thalamus development (GO:0021794)2.37234088
105regulation of integrin activation (GO:0033623)2.36142263
106cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.36131508
107cellular response to hepatocyte growth factor stimulus (GO:0035729)2.36113450
108response to hepatocyte growth factor (GO:0035728)2.36113450
109embryonic process involved in female pregnancy (GO:0060136)2.35835097
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35562168
111regulation of podosome assembly (GO:0071801)2.34801101
112polarized epithelial cell differentiation (GO:0030859)2.33581995
113establishment of tissue polarity (GO:0007164)2.33218269
114establishment of planar polarity (GO:0001736)2.33218269
115pyrimidine nucleobase catabolic process (GO:0006208)2.33198168
116intestinal absorption (GO:0050892)2.33075581
117CENP-A containing nucleosome assembly (GO:0034080)2.32493944
118chaperone-mediated protein transport (GO:0072321)2.31937895
119establishment of protein localization to mitochondrial membrane (GO:0090151)2.31827585
120embryonic digestive tract morphogenesis (GO:0048557)2.30038257
121chondrocyte proliferation (GO:0035988)2.29887150
122signal peptide processing (GO:0006465)2.29785015
123DNA integration (GO:0015074)2.28933239
124presynaptic membrane organization (GO:0097090)2.28871307
125endocardial cushion development (GO:0003197)2.28632291
126protein localization to lysosome (GO:0061462)2.28359149
127protein localization to vacuole (GO:0072665)2.28359149
128amyloid precursor protein metabolic process (GO:0042982)2.27923917
129embryonic foregut morphogenesis (GO:0048617)2.27686309
130L-serine metabolic process (GO:0006563)2.25528703
131lens fiber cell development (GO:0070307)2.24891541
132organ formation (GO:0048645)2.24650063
133peptidyl-tyrosine autophosphorylation (GO:0038083)2.24151334
134isoprenoid biosynthetic process (GO:0008299)2.24081473
135viral mRNA export from host cell nucleus (GO:0046784)2.23941072
136midgut development (GO:0007494)2.23444158
137regulation of gastrulation (GO:0010470)2.22018599
138smoothened signaling pathway (GO:0007224)2.20265811
139cell proliferation involved in metanephros development (GO:0072203)2.19928315
140midbrain development (GO:0030901)2.18992655
141regulation of mesoderm development (GO:2000380)2.18882806
142negative regulation of epidermis development (GO:0045683)2.18628755
143regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.17820801
144mesenchymal-epithelial cell signaling (GO:0060638)2.17630871
145nonmotile primary cilium assembly (GO:0035058)2.16331195
146mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.16046387
147axonemal dynein complex assembly (GO:0070286)2.15271733
148primitive streak formation (GO:0090009)2.15081002
149regulation of timing of cell differentiation (GO:0048505)2.13817806
150cilium movement (GO:0003341)2.13150330
151positive regulation of neuroblast proliferation (GO:0002052)2.13111725
152ventricular cardiac muscle cell development (GO:0055015)2.11405041
153dorsal/ventral axis specification (GO:0009950)2.09813459
154negative regulation of axon extension involved in axon guidance (GO:0048843)2.09609107
155olfactory bulb development (GO:0021772)2.08666576
156dorsal/ventral pattern formation (GO:0009953)2.08319777
157aldehyde catabolic process (GO:0046185)2.07068663
158regulation of organ formation (GO:0003156)2.06432884
159regulation of development, heterochronic (GO:0040034)2.05231435
160Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.05212313
161cilium morphogenesis (GO:0060271)2.03715714
162organ induction (GO:0001759)2.03696629
163non-canonical Wnt signaling pathway (GO:0035567)2.02317145
164neuron fate determination (GO:0048664)2.01910297
165hindbrain development (GO:0030902)2.01356269
166DNA replication checkpoint (GO:0000076)2.01200295
167hindlimb morphogenesis (GO:0035137)2.00986861
168DNA damage response, detection of DNA damage (GO:0042769)2.00402036
169tongue development (GO:0043586)1.99473773
170regulation of smoothened signaling pathway (GO:0008589)1.99205777
171histone exchange (GO:0043486)1.98977238
172glomerulus development (GO:0032835)1.98067840
173cochlea morphogenesis (GO:0090103)1.97533020
174cell-cell signaling involved in cell fate commitment (GO:0045168)1.97422009
175regulation of axon guidance (GO:1902667)1.96517622
176regulation of establishment of planar polarity (GO:0090175)1.95732779
177postsynaptic membrane organization (GO:0001941)1.95455919
178energy coupled proton transport, down electrochemical gradient (GO:0015985)1.94602652
179ATP synthesis coupled proton transport (GO:0015986)1.94602652
180cellular response to cholesterol (GO:0071397)1.94413882
181negative regulation of mesenchymal cell apoptotic process (GO:2001054)1.94121391
182neuronal stem cell maintenance (GO:0097150)1.93801886
183cell proliferation involved in kidney development (GO:0072111)1.93777340
184regulation of heart morphogenesis (GO:2000826)1.93671456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.62860704
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.16508748
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.96760034
4NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.10154679
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.92233404
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.56095478
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.45856349
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.45856349
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.45856349
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42772591
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.39799985
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31007995
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30748301
14EZH2_22144423_ChIP-Seq_EOC_Human2.28383823
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.20721149
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20048884
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.17963016
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.14557162
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.07855965
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.06439119
21SOX2_27498859_Chip-Seq_STOMACH_Mouse2.04855084
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.93535567
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91757540
24ZNF274_21170338_ChIP-Seq_K562_Hela1.86424222
25FUS_26573619_Chip-Seq_HEK293_Human1.86241032
26TCF3_18692474_ChIP-Seq_MEFs_Mouse1.85105432
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.82062960
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81170919
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.79152623
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.78589965
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76529147
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76180098
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75099111
34GBX2_23144817_ChIP-Seq_PC3_Human1.72895070
35EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.70185113
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67843830
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.65795866
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.65049920
39VDR_22108803_ChIP-Seq_LS180_Human1.65037251
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62925073
41EWS_26573619_Chip-Seq_HEK293_Human1.61921442
42P300_19829295_ChIP-Seq_ESCs_Human1.61308379
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.60878875
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59897608
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.58240752
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55378854
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.55307498
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.53881592
49RACK7_27058665_Chip-Seq_MCF-7_Human1.52416176
50CLOCK_20551151_ChIP-Seq_293T_Human1.52132831
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.51701759
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51672732
53SOX2_18692474_ChIP-Seq_MEFs_Mouse1.50586564
54* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47536618
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47504401
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47276845
57NANOG_16153702_ChIP-ChIP_HESCs_Human1.47200215
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47117943
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.45897314
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45676124
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45192722
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44494495
63SOX2_20726797_ChIP-Seq_SW620_Human1.44300896
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.43676755
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43280732
66* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42418892
67* RXR_22158963_ChIP-Seq_LIVER_Mouse1.42309364
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.41552480
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40004690
70RNF2_27304074_Chip-Seq_NSC_Mouse1.38631952
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.38474152
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37981037
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37787049
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37236606
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37153989
76LXR_22292898_ChIP-Seq_THP-1_Human1.36738613
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35367191
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35090504
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35090504
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34845054
81POU5F1_16518401_ChIP-PET_MESCs_Mouse1.33900496
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33663387
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33523627
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33129187
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30214495
86SOX17_20123909_ChIP-Seq_XEN_Mouse1.29449423
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28083358
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27535947
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26093902
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25554609
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.23247871
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22788177
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.22437403
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21849204
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21830910
96MYC_18555785_ChIP-Seq_MESCs_Mouse1.21733677
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21261076
98* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20435327
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20257391
100JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20154818
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.19260291
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18474135
103* ELK3_25401928_ChIP-Seq_HUVEC_Human1.18202915
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18100599
105IGF1R_20145208_ChIP-Seq_DFB_Human1.17859196
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17694441
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17549674
108SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17372315
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17348169
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16425681
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16187666
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15806420
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15198575
114TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14981080
115TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14956968
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14906755
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14056836
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12774187
119NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12519380
120ISL1_27105846_Chip-Seq_CPCs_Mouse1.12462156
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12024614
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11787830
123P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11751291
124STAT1_20625510_ChIP-Seq_HELA_Human1.10892233
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09758724
126TP53_22127205_ChIP-Seq_IMR90_Human1.08564184
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08558342
128GATA4_25053715_ChIP-Seq_YYC3_Human1.08112282
129OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07891780
130EP300_21415370_ChIP-Seq_HL-1_Mouse1.07468098
131KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07040303
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06929049
133TAF15_26573619_Chip-Seq_HEK293_Human1.06339721
134LXR_22158963_ChIP-Seq_LIVER_Mouse1.06284460
135MYC_18940864_ChIP-ChIP_HL60_Human1.05980570
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05961636
137TP63_19390658_ChIP-ChIP_HaCaT_Human1.05202523
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04877039
139SMAD4_21799915_ChIP-Seq_A2780_Human1.04801369
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04686778
141MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04515401
142ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04396476
143SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04139129
144GATA6_25053715_ChIP-Seq_YYC3_Human1.04112589
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03630276
146GATA1_26923725_Chip-Seq_HPCs_Mouse1.02334857
147JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02277408
148SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01756046
149SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01688696
150TP53_23651856_ChIP-Seq_MEFs_Mouse1.01624928
151KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00501629
152IRF1_19129219_ChIP-ChIP_H3396_Human1.00367268
153SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00056385
154RNF2_27304074_Chip-Seq_ESCs_Mouse0.99782463
155TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99360771
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99360771
157RING1B_27294783_Chip-Seq_NPCs_Mouse0.98976832
158MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98627476
159* AR_21909140_ChIP-Seq_LNCAP_Human0.98536112
160NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97289688
161WT1_19549856_ChIP-ChIP_CCG9911_Human0.96922385
162TP53_18474530_ChIP-ChIP_U2OS_Human0.96781622
163* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96181366
164TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95673620
165P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95377606
166SOX9_26525672_Chip-Seq_HEART_Mouse0.94386136
167CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94371080
168* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94348704
169SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93263432
170EZH2_27294783_Chip-Seq_ESCs_Mouse0.92942000
171FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92930916
172CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92908150
173ELK1_19687146_ChIP-ChIP_HELA_Human0.92819206
174TET1_21451524_ChIP-Seq_MESCs_Mouse0.92480672
175RING1B_27294783_Chip-Seq_ESCs_Mouse0.91869019
176* NANOG_21062744_ChIP-ChIP_HESCs_Human0.90564514
177EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90517193
178RARB_24833708_ChIP-Seq_LIVER_Mouse0.90321607
179KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89678386
180SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89212922
181EOMES_21245162_ChIP-Seq_HESCs_Human0.88896448
182NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88710687
183PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88539112
184NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87828711
185ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87324513
186TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87276700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.70022912
2MP0008438_abnormal_cutaneous_collagen4.40228122
3MP0005171_absent_coat_pigmentation3.92146093
4MP0000462_abnormal_digestive_system3.03705685
5MP0000566_synostosis2.90984901
6MP0005503_abnormal_tendon_morphology2.75762696
7MP0003283_abnormal_digestive_organ2.43787352
8MP0006292_abnormal_olfactory_placode2.36954212
9MP0002102_abnormal_ear_morphology2.27543218
10MP0005275_abnormal_skin_tensile2.22752358
11MP0003806_abnormal_nucleotide_metabolis2.16583836
12MP0000537_abnormal_urethra_morphology2.16136994
13MP0002249_abnormal_larynx_morphology2.14908903
14MP0003950_abnormal_plasma_membrane2.10783258
15MP0002282_abnormal_trachea_morphology2.06795406
16MP0002938_white_spotting1.93094988
17MP0001958_emphysema1.90354820
18MP0004272_abnormal_basement_membrane1.89948603
19MP0000762_abnormal_tongue_morphology1.85475239
20MP0004233_abnormal_muscle_weight1.84171929
21MP0004133_heterotaxia1.83261527
22MP0000920_abnormal_myelination1.78292806
23MP0008789_abnormal_olfactory_epithelium1.77172627
24MP0009053_abnormal_anal_canal1.71495957
25MP0003122_maternal_imprinting1.70884546
26MP0005508_abnormal_skeleton_morphology1.69159291
27MP0001529_abnormal_vocalization1.68753883
28MP0002234_abnormal_pharynx_morphology1.67097486
29MP0000467_abnormal_esophagus_morphology1.64614851
30MP0005257_abnormal_intraocular_pressure1.64134789
31MP0003385_abnormal_body_wall1.62940689
32MP0001299_abnormal_eye_distance/1.59873309
33MP0004134_abnormal_chest_morphology1.59710549
34MP0002653_abnormal_ependyma_morphology1.58125145
35MP0000778_abnormal_nervous_system1.58116691
36MP0009379_abnormal_foot_pigmentation1.57674793
37MP0003941_abnormal_skin_development1.56231125
38MP0003705_abnormal_hypodermis_morpholog1.53932922
39MP0009250_abnormal_appendicular_skeleto1.50755282
40MP0002932_abnormal_joint_morphology1.50362178
41MP0003011_delayed_dark_adaptation1.49329571
42MP0003938_abnormal_ear_development1.47265775
43MP0009384_cardiac_valve_regurgitation1.46496071
44MP0001293_anophthalmia1.46121004
45MP0005394_taste/olfaction_phenotype1.43430900
46MP0005499_abnormal_olfactory_system1.43430900
47MP0002060_abnormal_skin_morphology1.41981664
48MP0000049_abnormal_middle_ear1.41437003
49MP0003942_abnormal_urinary_system1.40639259
50MP0003119_abnormal_digestive_system1.39143679
51MP0002697_abnormal_eye_size1.39135205
52MP0001286_abnormal_eye_development1.38725994
53MP0000579_abnormal_nail_morphology1.36307128
54MP0003453_abnormal_keratinocyte_physiol1.32306070
55MP0002295_abnormal_pulmonary_circulatio1.27413086
56MP0003937_abnormal_limbs/digits/tail_de1.25837135
57MP0000470_abnormal_stomach_morphology1.25062523
58MP0000534_abnormal_ureter_morphology1.25007134
59MP0000003_abnormal_adipose_tissue1.24679803
60MP0003115_abnormal_respiratory_system1.24095474
61MP0009278_abnormal_bone_marrow1.23383869
62MP0001666_abnormal_nutrient_absorption1.21018529
63MP0002111_abnormal_tail_morphology1.20566579
64MP0002108_abnormal_muscle_morphology1.19894534
65MP0005085_abnormal_gallbladder_physiolo1.18024719
66MP0003755_abnormal_palate_morphology1.16891893
67MP0005623_abnormal_meninges_morphology1.13224664
68MP0005023_abnormal_wound_healing1.10706341
69MP0005377_hearing/vestibular/ear_phenot1.10180779
70MP0003878_abnormal_ear_physiology1.10180779
71MP0000613_abnormal_salivary_gland1.08337631
72MP0003279_aneurysm1.07164344
73MP0003880_abnormal_central_pattern1.05625241
74MP0000372_irregular_coat_pigmentation1.05431672
75MP0000026_abnormal_inner_ear1.05107014
76MP0000631_abnormal_neuroendocrine_gland1.04105237
77MP0003315_abnormal_perineum_morphology1.03751683
78MP0005253_abnormal_eye_physiology1.03117081
79MP0001485_abnormal_pinna_reflex1.02604832
80MP0001324_abnormal_eye_pigmentation1.02167153
81MP0005248_abnormal_Harderian_gland1.01914372
82MP0000678_abnormal_parathyroid_gland1.01161900
83MP0006054_spinal_hemorrhage1.01129194
84MP0008932_abnormal_embryonic_tissue1.00745481
85MP0002638_abnormal_pupillary_reflex1.00020520
86MP0003890_abnormal_embryonic-extraembry0.99723882
87MP0000163_abnormal_cartilage_morphology0.98692337
88MP0008004_abnormal_stomach_pH0.98629689
89MP0001346_abnormal_lacrimal_gland0.96463538
90MP0001340_abnormal_eyelid_morphology0.96458486
91MP0005187_abnormal_penis_morphology0.95777547
92MP0004885_abnormal_endolymph0.94726161
93MP0004264_abnormal_extraembryonic_tissu0.94554390
94MP0003861_abnormal_nervous_system0.93419933
95MP0001849_ear_inflammation0.91276075
96MP0005551_abnormal_eye_electrophysiolog0.91038444
97MP0002116_abnormal_craniofacial_bone0.90969408
98MP0005195_abnormal_posterior_eye0.90371734
99MP0010368_abnormal_lymphatic_system0.89391780
100MP0003935_abnormal_craniofacial_develop0.88766967
101MP0002736_abnormal_nociception_after0.88478963
102MP0001984_abnormal_olfaction0.88231609
103MP0005360_urolithiasis0.87686433
104MP0003634_abnormal_glial_cell0.87151841
105MP0000428_abnormal_craniofacial_morphol0.87062287
106MP0000383_abnormal_hair_follicle0.85533022
107MP0009840_abnormal_foam_cell0.84716538
108MP0002114_abnormal_axial_skeleton0.81636707
109MP0003136_yellow_coat_color0.81574394
110MP0000432_abnormal_head_morphology0.81544281
111MP0005197_abnormal_uvea_morphology0.80874435
112MP0010678_abnormal_skin_adnexa0.80544542
113MP0000538_abnormal_urinary_bladder0.80068096
114MP0002092_abnormal_eye_morphology0.80062628
115MP0002085_abnormal_embryonic_tissue0.79855355
116MP0002752_abnormal_somatic_nervous0.79081884
117MP0000639_abnormal_adrenal_gland0.78295209
118MP0000477_abnormal_intestine_morphology0.77588643
119MP0002109_abnormal_limb_morphology0.77509657
120MP0002233_abnormal_nose_morphology0.77416040
121MP0005408_hypopigmentation0.77071185
122MP0006072_abnormal_retinal_apoptosis0.75498830
123MP0005367_renal/urinary_system_phenotyp0.74728734
124MP0000516_abnormal_urinary_system0.74728734
125MP0004019_abnormal_vitamin_homeostasis0.72877956
126MP0000955_abnormal_spinal_cord0.72857100
127MP0003567_abnormal_fetal_cardiomyocyte0.72492474
128MP0000733_abnormal_muscle_development0.70620826
129MP0003943_abnormal_hepatobiliary_system0.70223025
130MP0005381_digestive/alimentary_phenotyp0.70211005
131MP0001177_atelectasis0.70189951
132MP0001879_abnormal_lymphatic_vessel0.69348406
133MP0002084_abnormal_developmental_patter0.69337931
134MP0003186_abnormal_redox_activity0.68874668
135MP0006276_abnormal_autonomic_nervous0.68817002
136MP0004197_abnormal_fetal_growth/weight/0.67671710
137MP0002751_abnormal_autonomic_nervous0.67200807
138MP0005365_abnormal_bile_salt0.66554790
139MP0002009_preneoplasia0.66095803
140MP0000013_abnormal_adipose_tissue0.65285722
141MP0003137_abnormal_impulse_conducting0.64724170
142MP0005391_vision/eye_phenotype0.63969784

Predicted human phenotypes

RankGene SetZ-score
1Coronal craniosynostosis (HP:0004440)4.81706029
2Premature skin wrinkling (HP:0100678)3.95067774
3Alacrima (HP:0000522)3.86463679
4Cerebral hypomyelination (HP:0006808)3.68069705
5Ulnar bowing (HP:0003031)3.40379766
6Turricephaly (HP:0000262)3.39281868
7Protrusio acetabuli (HP:0003179)3.19331765
8Ileus (HP:0002595)3.18381076
9Concave nail (HP:0001598)3.17994841
10Premature rupture of membranes (HP:0001788)3.17544884
11Decreased lacrimation (HP:0000633)2.78704543
12Pterygium (HP:0001059)2.77705747
13Septo-optic dysplasia (HP:0100842)2.74656268
14Rib fusion (HP:0000902)2.73453556
15Pancreatic islet-cell hyperplasia (HP:0004510)2.72057622
16Abnormal hemoglobin (HP:0011902)2.71296162
17True hermaphroditism (HP:0010459)2.69386090
18Abnormal umbilical cord blood vessels (HP:0011403)2.66726180
19Single umbilical artery (HP:0001195)2.66726180
20Abnormality of the fetal cardiovascular system (HP:0010948)2.66726180
21Colon cancer (HP:0003003)2.58242300
22Anophthalmia (HP:0000528)2.54895946
23Abnormality of the labia minora (HP:0012880)2.41234891
24Vertebral hypoplasia (HP:0008417)2.33582419
25Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.33582419
26Anteriorly placed anus (HP:0001545)2.32635250
27Fragile skin (HP:0001030)2.32291734
28Pancreatic fibrosis (HP:0100732)2.32097194
29Bifid tongue (HP:0010297)2.29948729
30Patchy hypopigmentation of hair (HP:0011365)2.29777033
31Abnormality of the aortic arch (HP:0012303)2.29389767
32White forelock (HP:0002211)2.27225053
33Occipital encephalocele (HP:0002085)2.26999503
34Partial duplication of the phalanx of hand (HP:0009999)2.26988441
35Broad metatarsal (HP:0001783)2.21906041
36Abnormality of the umbilical cord (HP:0010881)2.19527166
37Bilateral microphthalmos (HP:0007633)2.18770160
38Rectal fistula (HP:0100590)2.17315837
39Rectovaginal fistula (HP:0000143)2.17315837
40Diaphragmatic weakness (HP:0009113)2.17099001
41Intestinal atresia (HP:0011100)2.16131683
42Shallow orbits (HP:0000586)2.15498563
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14471884
44Partial duplication of thumb phalanx (HP:0009944)2.14023389
45Congenital glaucoma (HP:0001087)2.13825061
46Preaxial foot polydactyly (HP:0001841)2.13147395
47Alopecia of scalp (HP:0002293)2.12776724
48Opisthotonus (HP:0002179)2.12722045
49Vaginal fistula (HP:0004320)2.12713935
50Esophageal atresia (HP:0002032)2.11253166
51Large for gestational age (HP:0001520)2.08900804
52Abnormality of dentin (HP:0010299)2.08139693
53Redundant skin (HP:0001582)2.07451691
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05462961
55Gastrointestinal atresia (HP:0002589)2.04802254
56Vaginal atresia (HP:0000148)2.04281222
57Hyperglycinemia (HP:0002154)2.02544229
58Cutaneous finger syndactyly (HP:0010554)2.00272478
59Genital tract atresia (HP:0001827)1.99369171
60Carpal synostosis (HP:0009702)1.98492864
61Wormian bones (HP:0002645)1.97847433
62Pancreatic cysts (HP:0001737)1.97470073
63Molar tooth sign on MRI (HP:0002419)1.97348420
64Abnormality of midbrain morphology (HP:0002418)1.97348420
65Vascular tortuosity (HP:0004948)1.96611483
66Medial flaring of the eyebrow (HP:0010747)1.94716704
67Annular pancreas (HP:0001734)1.93525714
68Bowing of the arm (HP:0006488)1.93112855
69Bowed forearm bones (HP:0003956)1.93112855
70Blue sclerae (HP:0000592)1.91763825
71Hepatoblastoma (HP:0002884)1.91583929
72Maternal diabetes (HP:0009800)1.91346692
73Sclerocornea (HP:0000647)1.90837046
74Preaxial hand polydactyly (HP:0001177)1.90740438
75Soft skin (HP:0000977)1.90132942
76Supernumerary spleens (HP:0009799)1.90010206
77Congenital primary aphakia (HP:0007707)1.89652954
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.88829189
79Postaxial foot polydactyly (HP:0001830)1.86581429
80Abnormality of the 2nd finger (HP:0004100)1.86273913
81Hyperglycinuria (HP:0003108)1.85711660
82Gait imbalance (HP:0002141)1.85522740
83Keratoconus (HP:0000563)1.85320422
84Increased corneal curvature (HP:0100692)1.85320422
85Bell-shaped thorax (HP:0001591)1.84964726
86Stridor (HP:0010307)1.84913880
87Abnormality of the middle phalanges of the toes (HP:0010183)1.83595037
88Broad toe (HP:0001837)1.83249533
89Renal hypoplasia (HP:0000089)1.82170963
90Nephronophthisis (HP:0000090)1.82093641
91Anencephaly (HP:0002323)1.81802717
92Aplasia of the musculature (HP:0100854)1.81755570
93Choanal stenosis (HP:0000452)1.81750114
94Abnormality of glycine metabolism (HP:0010895)1.80879804
95Abnormality of serine family amino acid metabolism (HP:0010894)1.80879804
96Absent radius (HP:0003974)1.80609324
97Neurofibrillary tangles (HP:0002185)1.80530139
98Optic nerve hypoplasia (HP:0000609)1.80483878
99Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80350590
100Vitreoretinal degeneration (HP:0000655)1.80264398
101Cutaneous syndactyly (HP:0012725)1.80253730
102Abnormal respiratory motile cilium morphology (HP:0005938)1.80129184
103Abnormal respiratory epithelium morphology (HP:0012253)1.80129184
104Postaxial hand polydactyly (HP:0001162)1.79256288
105Abnormal number of incisors (HP:0011064)1.78831309
106Abnormal vertebral ossification (HP:0100569)1.78559955
107Broad alveolar ridges (HP:0000187)1.77977423
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77969646
109Nephrogenic diabetes insipidus (HP:0009806)1.77718630
110Abnormalities of placenta or umbilical cord (HP:0001194)1.77529865
111Neonatal short-limb short stature (HP:0008921)1.77352547
112Generalized amyotrophy (HP:0003700)1.76596245
113Abnormality of the pancreatic islet cells (HP:0006476)1.75843240
114Abnormality of endocrine pancreas physiology (HP:0012093)1.75843240
115Absent septum pellucidum (HP:0001331)1.74012377
116Aortic aneurysm (HP:0004942)1.73679205
117Hemivertebrae (HP:0002937)1.72676627
118Abnormal auditory evoked potentials (HP:0006958)1.72144456
119Hypoplastic pelvis (HP:0008839)1.72098753
120Hyperparathyroidism (HP:0000843)1.71972066
121Abnormal lung lobation (HP:0002101)1.71787816
122Gastrointestinal dysmotility (HP:0002579)1.71746498
123Atrophic scars (HP:0001075)1.71682080
124Pulmonary artery stenosis (HP:0004415)1.70714556
125Abnormal ciliary motility (HP:0012262)1.70420070
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.69898800
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69898800
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69821768
129Megalencephaly (HP:0001355)1.69632704
130Hypoplasia of the ulna (HP:0003022)1.69488068
131Intrahepatic cholestasis (HP:0001406)1.68827670
132Adrenal hypoplasia (HP:0000835)1.68717497
133Aplasia involving forearm bones (HP:0009822)1.68278208
134Absent forearm bone (HP:0003953)1.68278208
135Aortic dissection (HP:0002647)1.68041316
136Abnormal respiratory motile cilium physiology (HP:0012261)1.67231674
137Abnormality of placental membranes (HP:0011409)1.66688652
138Amniotic constriction ring (HP:0009775)1.66688652
139Pustule (HP:0200039)1.66446448
140Triphalangeal thumb (HP:0001199)1.65327931
141Peripheral hypomyelination (HP:0007182)1.64279154
142Broad hallux (HP:0010055)1.64143872
143Parakeratosis (HP:0001036)1.63821114
144Facial hemangioma (HP:0000329)1.63727302
145Midline defect of the nose (HP:0004122)1.62928815
146Leukodystrophy (HP:0002415)1.62925564
147Short humerus (HP:0005792)1.62221752
148Buphthalmos (HP:0000557)1.61994420
149Short 5th finger (HP:0009237)1.61644670
150Bladder diverticulum (HP:0000015)1.61407789
151Hypoplasia of the iris (HP:0007676)1.61179504
152Synostosis involving bones of the hand (HP:0004278)1.60956383
153Rhinitis (HP:0012384)1.58627937
154High anterior hairline (HP:0009890)1.58309867
155Wide anterior fontanel (HP:0000260)1.57535838
156Cystic liver disease (HP:0006706)1.55165173
157Duplication of thumb phalanx (HP:0009942)1.54741021
158Short tibia (HP:0005736)1.54671796
159Broad foot (HP:0001769)1.54617203
160Broad long bones (HP:0005622)1.54215573
161Humeroradial synostosis (HP:0003041)1.53812972
162Synostosis involving the elbow (HP:0003938)1.53812972
163Irregular epiphyses (HP:0010582)1.53597009
164Hypoplastic female external genitalia (HP:0012815)1.53258527
165Labial hypoplasia (HP:0000066)1.53142963
166Abnormality of the diencephalon (HP:0010662)1.51961069
167Short hallux (HP:0010109)1.51048100
168Abnormality of the antihelix (HP:0009738)1.49506141
169Shawl scrotum (HP:0000049)1.47641401
170Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.45769020
171Short 4th metacarpal (HP:0010044)1.45769020
172Dynein arm defect of respiratory motile cilia (HP:0012255)1.45572163
173Absent/shortened dynein arms (HP:0200106)1.45572163
174Aplasia/Hypoplasia of the hallux (HP:0008362)1.45192073
175Aplasia/Hypoplasia of the ulna (HP:0006495)1.45103102
176Myelomeningocele (HP:0002475)1.44942459
177Broad phalanx (HP:0006009)1.44563414
178Reticulocytopenia (HP:0001896)1.43849439
179Chronic hepatic failure (HP:0100626)1.43003938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.95081309
2DDR23.92354429
3ICK3.61866630
4STK393.49042392
5LIMK12.73793522
6PNCK2.52306053
7TESK22.51627416
8WEE12.44223200
9UHMK12.40460902
10PLK42.30351158
11CASK2.17409996
12TNIK2.13468544
13TYRO32.02651580
14BCR1.93712045
15EPHA41.93374328
16BMPR1B1.90090413
17WNK31.89737299
18MAP3K111.82176795
19TESK11.81625093
20OXSR11.80948102
21TRPM71.80671066
22MET1.79469938
23EPHB11.72248484
24ZAK1.64884889
25PDGFRA1.64155550
26DYRK1B1.62099471
27STK161.57996563
28BRSK21.56717559
29PIM21.56517486
30SRPK11.56272451
31MST41.54866413
32TTK1.52608427
33PLK31.52008594
34PRPF4B1.51587119
35TSSK61.47741806
36NEK11.47683276
37GRK11.46885579
38BUB11.46039256
39EPHB21.42314220
40PBK1.41644512
41WNK41.37155259
42CAMK2B1.37087874
43TGFBR11.36623797
44VRK21.36541832
45CDC71.35401014
46MATK1.34925142
47MAP2K21.34862558
48FGFR21.33108810
49MAP3K41.32356998
50MKNK21.29395491
51TRIM281.28857168
52PLK21.27410139
53LATS11.27309113
54PIK3CG1.24659018
55FGR1.24173000
56ACVR1B1.20788890
57CAMK2D1.17676559
58BMX1.16610314
59LMTK21.15162190
60MYLK1.14018899
61YES11.13894243
62PIK3CA1.11036735
63CDK71.10753121
64ILK1.09847284
65MAP3K61.09320066
66NEK21.08135541
67PRKD21.07909246
68VRK11.07802790
69PKN11.05838400
70EPHA21.05320561
71MAP3K101.05137659
72PRKG21.04752529
73MARK11.03729498
74MAP4K21.02681977
75BCKDK1.02188526
76CAMK2G1.02084960
77CSNK1G11.02032881
78ROCK20.99475880
79PAK20.97545909
80CSNK1G20.96786231
81GSK3A0.96455384
82PLK10.95773038
83ADRBK20.95757668
84PAK40.94236945
85CSNK1G30.93083712
86CSNK1A1L0.92212888
87PINK10.91186911
88MAPK130.89646688
89MAPKAPK50.89492424
90MKNK10.86932887
91BRSK10.86806021
92NEK60.86439420
93PRKD30.86395903
94PTK20.86089656
95PTK60.84662812
96CSK0.83064800
97DYRK20.81675523
98LATS20.81310530
99FRK0.77726511
100PRKCG0.77480475
101PRKD10.75376126
102NTRK20.75266386
103NTRK10.74393218
104CDC42BPA0.72619600
105MAP2K70.71937192
106INSRR0.71623868
107PHKG20.71078159
108PHKG10.71078159
109PAK10.70161020
110PRKCE0.64445142
111CLK10.63633119
112FGFR10.62473908
113PDK20.61813942
114PASK0.61428550
115MINK10.60631413
116DYRK30.57797960
117PAK30.57467525
118TIE10.57360491
119NME10.56776729
120TAF10.55760397
121PDGFRB0.54608325
122MELK0.54338980
123AURKB0.53503882
124LRRK20.51815896
125CDK30.51640280
126ERBB30.50963311
127NEK90.49217942
128PAK60.48135590
129DAPK30.48052916
130ADRBK10.47365478
131MAPKAPK20.46735911
132ROCK10.46703377
133ERBB20.44906346
134TLK10.42873584
135CDK60.42578188
136DMPK0.42347050
137NTRK30.42134069
138CDK190.41709564
139ERBB40.40481371
140MTOR0.40288287
141DYRK1A0.39378658
142RPS6KA60.39237290
143RPS6KC10.39037273
144RPS6KL10.39037273
145NUAK10.37949982
146AKT30.37935603
147CDK140.36792856
148WNK10.35463499
149CDK80.35220634
150STK38L0.35120545
151AURKA0.33802047
152CHEK20.33048125
153STK30.32138948
154CDK150.30803100
155FER0.30500772

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.40602634
2Steroid biosynthesis_Homo sapiens_hsa001002.93901611
3Sulfur metabolism_Homo sapiens_hsa009202.88501233
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.75629145
5Glutathione metabolism_Homo sapiens_hsa004802.26552145
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25340227
7Folate biosynthesis_Homo sapiens_hsa007902.17855770
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17452017
9Arginine and proline metabolism_Homo sapiens_hsa003302.15626820
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12042425
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09844111
12Mismatch repair_Homo sapiens_hsa034301.92788000
13Fatty acid biosynthesis_Homo sapiens_hsa000611.87405598
14Hedgehog signaling pathway_Homo sapiens_hsa043401.87173010
15Fat digestion and absorption_Homo sapiens_hsa049751.86716215
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.86218459
17Hippo signaling pathway_Homo sapiens_hsa043901.80885584
18Nitrogen metabolism_Homo sapiens_hsa009101.76301917
19Basal cell carcinoma_Homo sapiens_hsa052171.72491503
20Base excision repair_Homo sapiens_hsa034101.69095362
21Fatty acid metabolism_Homo sapiens_hsa012121.68872408
22Protein export_Homo sapiens_hsa030601.67964251
23Tight junction_Homo sapiens_hsa045301.65310765
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62802527
25Linoleic acid metabolism_Homo sapiens_hsa005911.57674536
26Histidine metabolism_Homo sapiens_hsa003401.55461153
27Arachidonic acid metabolism_Homo sapiens_hsa005901.51392818
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50653597
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46616495
30DNA replication_Homo sapiens_hsa030301.46247127
31Proteasome_Homo sapiens_hsa030501.44281948
32TGF-beta signaling pathway_Homo sapiens_hsa043501.43755132
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39905055
34Ether lipid metabolism_Homo sapiens_hsa005651.39637068
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33961788
36Notch signaling pathway_Homo sapiens_hsa043301.25606387
37ECM-receptor interaction_Homo sapiens_hsa045121.23954641
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21025813
39Chemical carcinogenesis_Homo sapiens_hsa052041.20021089
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18493019
41Retinol metabolism_Homo sapiens_hsa008301.15324092
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13138409
43Fanconi anemia pathway_Homo sapiens_hsa034601.12706504
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.10633318
45Sulfur relay system_Homo sapiens_hsa041221.10506034
46RNA polymerase_Homo sapiens_hsa030201.05822554
47Mineral absorption_Homo sapiens_hsa049781.05581776
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03968908
49Bladder cancer_Homo sapiens_hsa052191.03213632
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02245439
51Non-homologous end-joining_Homo sapiens_hsa034500.96252418
52Vitamin digestion and absorption_Homo sapiens_hsa049770.93268442
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92767388
54Protein digestion and absorption_Homo sapiens_hsa049740.91824872
55Phototransduction_Homo sapiens_hsa047440.91276075
56Adherens junction_Homo sapiens_hsa045200.86007332
57Fatty acid degradation_Homo sapiens_hsa000710.84907815
58Oxidative phosphorylation_Homo sapiens_hsa001900.82602000
59Propanoate metabolism_Homo sapiens_hsa006400.82272129
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82242888
61Butanoate metabolism_Homo sapiens_hsa006500.81652937
62Arginine biosynthesis_Homo sapiens_hsa002200.81420098
63Biosynthesis of amino acids_Homo sapiens_hsa012300.80130522
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79608056
65Wnt signaling pathway_Homo sapiens_hsa043100.79082786
66Cardiac muscle contraction_Homo sapiens_hsa042600.79067067
67Axon guidance_Homo sapiens_hsa043600.78412993
68Parkinsons disease_Homo sapiens_hsa050120.77868864
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.75782904
70Focal adhesion_Homo sapiens_hsa045100.75657463
71Phenylalanine metabolism_Homo sapiens_hsa003600.75646255
72Spliceosome_Homo sapiens_hsa030400.75526296
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74922569
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74431926
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73721964
76Basal transcription factors_Homo sapiens_hsa030220.72995979
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72526862
78Nucleotide excision repair_Homo sapiens_hsa034200.70650220
79Caffeine metabolism_Homo sapiens_hsa002320.70348371
80One carbon pool by folate_Homo sapiens_hsa006700.68787588
81Ribosome_Homo sapiens_hsa030100.68476501
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67611126
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66778433
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65526500
85Carbon metabolism_Homo sapiens_hsa012000.64520519
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63177502
87Melanogenesis_Homo sapiens_hsa049160.63127777
88Proteoglycans in cancer_Homo sapiens_hsa052050.62544716
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.62238597
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61155884
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60679365
92Cell cycle_Homo sapiens_hsa041100.59282357
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57828370
94Peroxisome_Homo sapiens_hsa041460.57635182
95Tryptophan metabolism_Homo sapiens_hsa003800.57460439
96Pyruvate metabolism_Homo sapiens_hsa006200.57062646
97RNA transport_Homo sapiens_hsa030130.55872450
98Purine metabolism_Homo sapiens_hsa002300.55782745
99Pyrimidine metabolism_Homo sapiens_hsa002400.55659843
100Vitamin B6 metabolism_Homo sapiens_hsa007500.55443385
101RNA degradation_Homo sapiens_hsa030180.53887653
102Metabolic pathways_Homo sapiens_hsa011000.53535470
103Starch and sucrose metabolism_Homo sapiens_hsa005000.53442428
104Cocaine addiction_Homo sapiens_hsa050300.53234944
105Tyrosine metabolism_Homo sapiens_hsa003500.52335179
106N-Glycan biosynthesis_Homo sapiens_hsa005100.51561845
107Small cell lung cancer_Homo sapiens_hsa052220.51253570
108Shigellosis_Homo sapiens_hsa051310.49499464
109Sphingolipid metabolism_Homo sapiens_hsa006000.47466943
110beta-Alanine metabolism_Homo sapiens_hsa004100.45990439
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45147905
112Homologous recombination_Homo sapiens_hsa034400.43642237
113p53 signaling pathway_Homo sapiens_hsa041150.43076139
114MicroRNAs in cancer_Homo sapiens_hsa052060.42148345
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40561061
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40495199
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40306545
118PPAR signaling pathway_Homo sapiens_hsa033200.40285869
119Alzheimers disease_Homo sapiens_hsa050100.39466903
120Renin-angiotensin system_Homo sapiens_hsa046140.38796925
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38004975
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37614964
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.37436328
124Huntingtons disease_Homo sapiens_hsa050160.37383353
125Pathways in cancer_Homo sapiens_hsa052000.36304959
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.36072023
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.34280532
128Selenocompound metabolism_Homo sapiens_hsa004500.33778892
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32952337

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