

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.82037437 |
| 2 | proteasome assembly (GO:0043248) | 5.47873986 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 4.99154343 |
| 4 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.99154343 |
| 5 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.84566229 |
| 6 | chaperone-mediated protein transport (GO:0072321) | 4.63322644 |
| 7 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.61624806 |
| 8 | respiratory chain complex IV assembly (GO:0008535) | 4.30793391 |
| 9 | respiratory electron transport chain (GO:0022904) | 4.25833494 |
| 10 | electron transport chain (GO:0022900) | 4.16999650 |
| 11 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.12527451 |
| 12 | regulation of mitochondrial translation (GO:0070129) | 4.10807662 |
| 13 | protein complex biogenesis (GO:0070271) | 3.98518393 |
| 14 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.92530936 |
| 15 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.91440987 |
| 16 | rRNA modification (GO:0000154) | 3.91259367 |
| 17 | establishment of integrated proviral latency (GO:0075713) | 3.81606712 |
| 18 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.80544392 |
| 19 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.79235393 |
| 20 | negative regulation of ligase activity (GO:0051352) | 3.79235393 |
| 21 | protein targeting to mitochondrion (GO:0006626) | 3.77484219 |
| 22 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.75943863 |
| 23 | protein neddylation (GO:0045116) | 3.73648094 |
| 24 | cytochrome complex assembly (GO:0017004) | 3.70857628 |
| 25 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.66022463 |
| 26 | ribosomal small subunit assembly (GO:0000028) | 3.64577687 |
| 27 | ribosomal large subunit biogenesis (GO:0042273) | 3.62865079 |
| 28 | NADH dehydrogenase complex assembly (GO:0010257) | 3.58698022 |
| 29 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.58698022 |
| 30 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.58698022 |
| 31 | establishment of protein localization to mitochondrion (GO:0072655) | 3.50755617 |
| 32 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.48622642 |
| 33 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.46692532 |
| 34 | termination of RNA polymerase III transcription (GO:0006386) | 3.45954502 |
| 35 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.45954502 |
| 36 | protein localization to mitochondrion (GO:0070585) | 3.41435548 |
| 37 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.39123800 |
| 38 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.39123800 |
| 39 | rRNA methylation (GO:0031167) | 3.38913719 |
| 40 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.38595041 |
| 41 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.38595041 |
| 42 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.38595041 |
| 43 | positive regulation of ligase activity (GO:0051351) | 3.33859089 |
| 44 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.29689760 |
| 45 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.29689760 |
| 46 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.29234148 |
| 47 | maturation of SSU-rRNA (GO:0030490) | 3.28589754 |
| 48 | establishment of viral latency (GO:0019043) | 3.27998258 |
| 49 | translation (GO:0006412) | 3.27637224 |
| 50 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.27348353 |
| 51 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.25445342 |
| 52 | ribosomal small subunit biogenesis (GO:0042274) | 3.25444938 |
| 53 | cotranslational protein targeting to membrane (GO:0006613) | 3.25116333 |
| 54 | cullin deneddylation (GO:0010388) | 3.24765496 |
| 55 | protein targeting to ER (GO:0045047) | 3.19343862 |
| 56 | peptidyl-histidine modification (GO:0018202) | 3.19093821 |
| 57 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.16652222 |
| 58 | CENP-A containing nucleosome assembly (GO:0034080) | 3.15636713 |
| 59 | chromatin remodeling at centromere (GO:0031055) | 3.15608779 |
| 60 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.13862921 |
| 61 | ribosome assembly (GO:0042255) | 3.12711622 |
| 62 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.11817494 |
| 63 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.08753332 |
| 64 | protein localization to endoplasmic reticulum (GO:0070972) | 3.07821781 |
| 65 | pseudouridine synthesis (GO:0001522) | 3.07027702 |
| 66 | cellular component biogenesis (GO:0044085) | 3.05843272 |
| 67 | regulation of ligase activity (GO:0051340) | 3.05590248 |
| 68 | protein deneddylation (GO:0000338) | 3.04602125 |
| 69 | oxidative phosphorylation (GO:0006119) | 3.04502594 |
| 70 | maturation of 5.8S rRNA (GO:0000460) | 3.01712488 |
| 71 | translational termination (GO:0006415) | 2.96231542 |
| 72 | viral transcription (GO:0019083) | 2.96117613 |
| 73 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.95711432 |
| 74 | 7-methylguanosine mRNA capping (GO:0006370) | 2.91760503 |
| 75 | mitochondrial transport (GO:0006839) | 2.90838688 |
| 76 | ATP biosynthetic process (GO:0006754) | 2.88242352 |
| 77 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.88119054 |
| 78 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.87598825 |
| 79 | GTP biosynthetic process (GO:0006183) | 2.85560987 |
| 80 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.85556431 |
| 81 | mitotic metaphase plate congression (GO:0007080) | 2.85412444 |
| 82 | intracellular protein transmembrane import (GO:0044743) | 2.84757870 |
| 83 | rRNA processing (GO:0006364) | 2.83555565 |
| 84 | 7-methylguanosine RNA capping (GO:0009452) | 2.83026975 |
| 85 | RNA capping (GO:0036260) | 2.83026975 |
| 86 | translational initiation (GO:0006413) | 2.81026803 |
| 87 | spliceosomal snRNP assembly (GO:0000387) | 2.80919853 |
| 88 | inner mitochondrial membrane organization (GO:0007007) | 2.80900758 |
| 89 | lactate metabolic process (GO:0006089) | 2.79818020 |
| 90 | DNA damage response, detection of DNA damage (GO:0042769) | 2.78058401 |
| 91 | formation of translation preinitiation complex (GO:0001731) | 2.76542373 |
| 92 | negative regulation of protein ubiquitination (GO:0031397) | 2.73269981 |
| 93 | protein maturation by protein folding (GO:0022417) | 2.72804966 |
| 94 | rRNA metabolic process (GO:0016072) | 2.70512554 |
| 95 | DNA replication checkpoint (GO:0000076) | 2.68724178 |
| 96 | hydrogen ion transmembrane transport (GO:1902600) | 2.68392381 |
| 97 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.67732584 |
| 98 | transcription from mitochondrial promoter (GO:0006390) | 2.67509640 |
| 99 | regulation of cellular amine metabolic process (GO:0033238) | 2.66739701 |
| 100 | translational elongation (GO:0006414) | 2.65091048 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.50815702 |
| 2 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.85789581 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.32716619 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.90335958 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.52338068 |
| 6 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.50458553 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.44966136 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.42287531 |
| 9 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.12025625 |
| 10 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.05667809 |
| 11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.02130356 |
| 12 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.96100546 |
| 13 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 2.83540006 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.66889328 |
| 15 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.63291752 |
| 16 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.54335427 |
| 17 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.53751297 |
| 18 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.52609675 |
| 19 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.50830121 |
| 20 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.50678165 |
| 21 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.49335717 |
| 22 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.49220073 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.43010943 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.29306461 |
| 25 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.27073595 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.25495697 |
| 27 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.21930450 |
| 28 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.20469612 |
| 29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.18746640 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.17187551 |
| 31 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.14772117 |
| 32 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.14377289 |
| 33 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.08676639 |
| 34 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.02785319 |
| 35 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.93222423 |
| 36 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.91214810 |
| 37 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.88665710 |
| 38 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.81035193 |
| 39 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.71431073 |
| 40 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.70871770 |
| 41 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.70849057 |
| 42 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.65211301 |
| 43 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.64790052 |
| 44 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.58039151 |
| 45 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.55807589 |
| 46 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.51991462 |
| 47 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.51293372 |
| 48 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.50249136 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.47833317 |
| 50 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.46596175 |
| 51 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.45192954 |
| 52 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.39824140 |
| 53 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.39485203 |
| 54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.37825040 |
| 55 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.32596200 |
| 56 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.29752689 |
| 57 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.27848217 |
| 58 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.26710218 |
| 59 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.25812366 |
| 60 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.19968815 |
| 61 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.19518070 |
| 62 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.14111083 |
| 63 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.13737789 |
| 64 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.13092463 |
| 65 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.12894956 |
| 66 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.11603645 |
| 67 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.11504178 |
| 68 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.06377362 |
| 69 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.06281827 |
| 70 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03593154 |
| 71 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.03575968 |
| 72 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.01972886 |
| 73 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.98361379 |
| 74 | EWS_26573619_Chip-Seq_HEK293_Human | 0.97820602 |
| 75 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.95731131 |
| 76 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.95469331 |
| 77 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.95348461 |
| 78 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94740690 |
| 79 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.91953925 |
| 80 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.90937379 |
| 81 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.90181620 |
| 82 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.89689717 |
| 83 | VDR_22108803_ChIP-Seq_LS180_Human | 0.89263054 |
| 84 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.87176302 |
| 85 | FUS_26573619_Chip-Seq_HEK293_Human | 0.85588721 |
| 86 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.84509772 |
| 87 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.83872389 |
| 88 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.81214222 |
| 89 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.80991472 |
| 90 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.78414325 |
| 91 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.78379641 |
| 92 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.77889748 |
| 93 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.77212748 |
| 94 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.76813949 |
| 95 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.73683865 |
| 96 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.73094403 |
| 97 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.73076218 |
| 98 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.71372807 |
| 99 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.70026736 |
| 100 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.68963499 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 3.28702973 |
| 2 | MP0008058_abnormal_DNA_repair | 3.02040263 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 2.81558097 |
| 4 | MP0002163_abnormal_gland_morphology | 2.68184976 |
| 5 | MP0003806_abnormal_nucleotide_metabolis | 2.67786672 |
| 6 | MP0003186_abnormal_redox_activity | 2.65616961 |
| 7 | MP0003786_premature_aging | 2.64697266 |
| 8 | MP0009697_abnormal_copulation | 2.40580251 |
| 9 | MP0003195_calcinosis | 2.36643582 |
| 10 | MP0002938_white_spotting | 2.31096840 |
| 11 | MP0003111_abnormal_nucleus_morphology | 2.30947593 |
| 12 | MP0010030_abnormal_orbit_morphology | 2.30170989 |
| 13 | MP0010094_abnormal_chromosome_stability | 2.30158988 |
| 14 | MP0003718_maternal_effect | 2.20814603 |
| 15 | MP0003077_abnormal_cell_cycle | 2.10800745 |
| 16 | MP0008932_abnormal_embryonic_tissue | 2.06988711 |
| 17 | MP0006036_abnormal_mitochondrial_physio | 2.06515591 |
| 18 | MP0003123_paternal_imprinting | 2.03705232 |
| 19 | MP0006035_abnormal_mitochondrial_morpho | 1.94272849 |
| 20 | MP0009379_abnormal_foot_pigmentation | 1.87953400 |
| 21 | MP0000372_irregular_coat_pigmentation | 1.85493980 |
| 22 | MP0008007_abnormal_cellular_replicative | 1.79613789 |
| 23 | MP0005379_endocrine/exocrine_gland_phen | 1.69221840 |
| 24 | MP0006072_abnormal_retinal_apoptosis | 1.68889806 |
| 25 | MP0008789_abnormal_olfactory_epithelium | 1.66924611 |
| 26 | MP0003941_abnormal_skin_development | 1.59397776 |
| 27 | MP0001529_abnormal_vocalization | 1.58629422 |
| 28 | MP0005084_abnormal_gallbladder_morpholo | 1.55195935 |
| 29 | MP0006292_abnormal_olfactory_placode | 1.52945622 |
| 30 | MP0002160_abnormal_reproductive_system | 1.50088837 |
| 31 | MP0002132_abnormal_respiratory_system | 1.47338418 |
| 32 | MP0000358_abnormal_cell_content/ | 1.45492926 |
| 33 | MP0002090_abnormal_vision | 1.42759842 |
| 34 | MP0001293_anophthalmia | 1.34219001 |
| 35 | MP0005408_hypopigmentation | 1.31057710 |
| 36 | MP0001661_extended_life_span | 1.29702370 |
| 37 | MP0008995_early_reproductive_senescence | 1.28702460 |
| 38 | MP0002233_abnormal_nose_morphology | 1.27908943 |
| 39 | MP0002277_abnormal_respiratory_mucosa | 1.27634032 |
| 40 | MP0002837_dystrophic_cardiac_calcinosis | 1.25032629 |
| 41 | MP0003937_abnormal_limbs/digits/tail_de | 1.24970033 |
| 42 | MP0001764_abnormal_homeostasis | 1.23995845 |
| 43 | MP0003136_yellow_coat_color | 1.19271981 |
| 44 | MP0005332_abnormal_amino_acid | 1.12022242 |
| 45 | MP0000647_abnormal_sebaceous_gland | 1.11564071 |
| 46 | MP0005389_reproductive_system_phenotype | 1.10450283 |
| 47 | MP0002210_abnormal_sex_determination | 1.08821755 |
| 48 | MP0003011_delayed_dark_adaptation | 1.06999559 |
| 49 | MP0003121_genomic_imprinting | 1.06832102 |
| 50 | MP0002102_abnormal_ear_morphology | 1.02521840 |
| 51 | MP0001984_abnormal_olfaction | 1.01895521 |
| 52 | MP0004133_heterotaxia | 1.01631135 |
| 53 | MP0001929_abnormal_gametogenesis | 0.99995647 |
| 54 | MP0003122_maternal_imprinting | 0.97075602 |
| 55 | MP0008877_abnormal_DNA_methylation | 0.96850488 |
| 56 | MP0005394_taste/olfaction_phenotype | 0.96195879 |
| 57 | MP0005499_abnormal_olfactory_system | 0.96195879 |
| 58 | MP0001542_abnormal_bone_strength | 0.95376144 |
| 59 | MP0005395_other_phenotype | 0.95338932 |
| 60 | MP0000049_abnormal_middle_ear | 0.94569473 |
| 61 | MP0005253_abnormal_eye_physiology | 0.92296705 |
| 62 | MP0001145_abnormal_male_reproductive | 0.92158650 |
| 63 | MP0005410_abnormal_fertilization | 0.91878476 |
| 64 | MP0002928_abnormal_bile_duct | 0.91566161 |
| 65 | MP0003315_abnormal_perineum_morphology | 0.91377576 |
| 66 | MP0002653_abnormal_ependyma_morphology | 0.89834175 |
| 67 | MP0000653_abnormal_sex_gland | 0.89558550 |
| 68 | MP0008875_abnormal_xenobiotic_pharmacok | 0.89333026 |
| 69 | MP0001697_abnormal_embryo_size | 0.87660440 |
| 70 | MP0002234_abnormal_pharynx_morphology | 0.86698298 |
| 71 | MP0001905_abnormal_dopamine_level | 0.84259927 |
| 72 | MP0008872_abnormal_physiological_respon | 0.83322965 |
| 73 | MP0003755_abnormal_palate_morphology | 0.82932753 |
| 74 | MP0001881_abnormal_mammary_gland | 0.82760183 |
| 75 | MP0005501_abnormal_skin_physiology | 0.82529031 |
| 76 | MP0010386_abnormal_urinary_bladder | 0.82279490 |
| 77 | MP0000350_abnormal_cell_proliferation | 0.81998352 |
| 78 | MP0002095_abnormal_skin_pigmentation | 0.81979319 |
| 79 | MP0001919_abnormal_reproductive_system | 0.81240709 |
| 80 | MP0004147_increased_porphyrin_level | 0.78180036 |
| 81 | MP0002177_abnormal_outer_ear | 0.77975650 |
| 82 | MP0002697_abnormal_eye_size | 0.77222852 |
| 83 | MP0001286_abnormal_eye_development | 0.76851510 |
| 84 | MP0000516_abnormal_urinary_system | 0.75582473 |
| 85 | MP0005367_renal/urinary_system_phenotyp | 0.75582473 |
| 86 | MP0004019_abnormal_vitamin_homeostasis | 0.74436599 |
| 87 | MP0002085_abnormal_embryonic_tissue | 0.73072418 |
| 88 | MP0001730_embryonic_growth_arrest | 0.73063362 |
| 89 | MP0005220_abnormal_exocrine_pancreas | 0.72796893 |
| 90 | MP0003698_abnormal_male_reproductive | 0.71238787 |
| 91 | MP0003950_abnormal_plasma_membrane | 0.70745690 |
| 92 | MP0003567_abnormal_fetal_cardiomyocyte | 0.70552788 |
| 93 | MP0005330_cardiomyopathy | 0.69506518 |
| 94 | MP0002282_abnormal_trachea_morphology | 0.69273370 |
| 95 | MP0003938_abnormal_ear_development | 0.68234250 |
| 96 | MP0001944_abnormal_pancreas_morphology | 0.67033901 |
| 97 | MP0002111_abnormal_tail_morphology | 0.66282301 |
| 98 | MP0004142_abnormal_muscle_tone | 0.65736795 |
| 99 | MP0002295_abnormal_pulmonary_circulatio | 0.65669378 |
| 100 | MP0003252_abnormal_bile_duct | 0.64533753 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.07352301 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.71119476 |
| 3 | Acute encephalopathy (HP:0006846) | 4.65727801 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.45391096 |
| 5 | Increased hepatocellular lipid droplets (HP:0006565) | 4.35471568 |
| 6 | Progressive macrocephaly (HP:0004481) | 4.26685046 |
| 7 | Increased CSF lactate (HP:0002490) | 4.20869376 |
| 8 | Renal Fanconi syndrome (HP:0001994) | 4.16628780 |
| 9 | Lipid accumulation in hepatocytes (HP:0006561) | 4.01749870 |
| 10 | Hepatocellular necrosis (HP:0001404) | 3.79705210 |
| 11 | Hepatic necrosis (HP:0002605) | 3.62223040 |
| 12 | Cerebral edema (HP:0002181) | 3.37868708 |
| 13 | Increased serum pyruvate (HP:0003542) | 3.04569045 |
| 14 | Increased serum lactate (HP:0002151) | 3.02703316 |
| 15 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.01637649 |
| 16 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.01637649 |
| 17 | Increased intramyocellular lipid droplets (HP:0012240) | 3.01012492 |
| 18 | 3-Methylglutaconic aciduria (HP:0003535) | 2.92181268 |
| 19 | Abnormality of glycolysis (HP:0004366) | 2.88140606 |
| 20 | Lactic acidosis (HP:0003128) | 2.87501000 |
| 21 | Exercise intolerance (HP:0003546) | 2.83822827 |
| 22 | Reticulocytopenia (HP:0001896) | 2.79912930 |
| 23 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.77346536 |
| 24 | Abnormality of methionine metabolism (HP:0010901) | 2.75378633 |
| 25 | Abnormality of renal resorption (HP:0011038) | 2.74076210 |
| 26 | Type I transferrin isoform profile (HP:0003642) | 2.69598666 |
| 27 | Respiratory failure (HP:0002878) | 2.68142990 |
| 28 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.55370899 |
| 29 | Macrocytic anemia (HP:0001972) | 2.48648548 |
| 30 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.48533534 |
| 31 | Methylmalonic acidemia (HP:0002912) | 2.47443231 |
| 32 | Increased muscle lipid content (HP:0009058) | 2.45899564 |
| 33 | Exertional dyspnea (HP:0002875) | 2.45552091 |
| 34 | Respiratory difficulties (HP:0002880) | 2.43348835 |
| 35 | Pancreatic fibrosis (HP:0100732) | 2.43086004 |
| 36 | Pancreatic cysts (HP:0001737) | 2.41859577 |
| 37 | Congenital, generalized hypertrichosis (HP:0004540) | 2.41807459 |
| 38 | Lethargy (HP:0001254) | 2.36281539 |
| 39 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.36254383 |
| 40 | True hermaphroditism (HP:0010459) | 2.33684114 |
| 41 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.32210813 |
| 42 | Hyperphosphaturia (HP:0003109) | 2.32202730 |
| 43 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.31114604 |
| 44 | Glycosuria (HP:0003076) | 2.28765585 |
| 45 | Abnormality of urine glucose concentration (HP:0011016) | 2.28765585 |
| 46 | Abnormal number of erythroid precursors (HP:0012131) | 2.28657165 |
| 47 | Leukodystrophy (HP:0002415) | 2.27026840 |
| 48 | Hyperglycinemia (HP:0002154) | 2.26478628 |
| 49 | Sensory axonal neuropathy (HP:0003390) | 2.22055093 |
| 50 | Sparse eyelashes (HP:0000653) | 2.21518672 |
| 51 | Methylmalonic aciduria (HP:0012120) | 2.18746216 |
| 52 | Hypoglycemic coma (HP:0001325) | 2.17830237 |
| 53 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.16835444 |
| 54 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.16835444 |
| 55 | Abnormal protein glycosylation (HP:0012346) | 2.16835444 |
| 56 | Abnormal glycosylation (HP:0012345) | 2.16835444 |
| 57 | Medial flaring of the eyebrow (HP:0010747) | 2.10077794 |
| 58 | Adrenal hypoplasia (HP:0000835) | 2.08859448 |
| 59 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.05845104 |
| 60 | Abnormality of serum amino acid levels (HP:0003112) | 2.04611396 |
| 61 | Optic disc pallor (HP:0000543) | 2.02522479 |
| 62 | Sclerocornea (HP:0000647) | 2.02346781 |
| 63 | Entropion (HP:0000621) | 2.00490804 |
| 64 | Gout (HP:0001997) | 1.99962388 |
| 65 | Reduced antithrombin III activity (HP:0001976) | 1.98510642 |
| 66 | CNS demyelination (HP:0007305) | 1.97151756 |
| 67 | X-linked dominant inheritance (HP:0001423) | 1.96852748 |
| 68 | Molar tooth sign on MRI (HP:0002419) | 1.96449849 |
| 69 | Abnormality of midbrain morphology (HP:0002418) | 1.96449849 |
| 70 | Meckel diverticulum (HP:0002245) | 1.93516618 |
| 71 | Abnormality of the anterior horn cell (HP:0006802) | 1.91134282 |
| 72 | Degeneration of anterior horn cells (HP:0002398) | 1.91134282 |
| 73 | Hypoplastic pelvis (HP:0008839) | 1.89359594 |
| 74 | Megaloblastic anemia (HP:0001889) | 1.89159721 |
| 75 | Absent thumb (HP:0009777) | 1.84216150 |
| 76 | Delayed CNS myelination (HP:0002188) | 1.83076731 |
| 77 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.82537706 |
| 78 | Abnormality of alanine metabolism (HP:0010916) | 1.82537706 |
| 79 | Hyperalaninemia (HP:0003348) | 1.82537706 |
| 80 | Abnormality of the ileum (HP:0001549) | 1.81778885 |
| 81 | Congenital primary aphakia (HP:0007707) | 1.81289784 |
| 82 | Abnormality of the preputium (HP:0100587) | 1.80341373 |
| 83 | Horseshoe kidney (HP:0000085) | 1.79769904 |
| 84 | Rough bone trabeculation (HP:0100670) | 1.79004785 |
| 85 | Hypoglycemic seizures (HP:0002173) | 1.78214480 |
| 86 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.77989458 |
| 87 | Median cleft lip (HP:0000161) | 1.77018724 |
| 88 | Nephrogenic diabetes insipidus (HP:0009806) | 1.75820416 |
| 89 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.72283958 |
| 90 | Renal tubular dysfunction (HP:0000124) | 1.70931976 |
| 91 | Abnormal lung lobation (HP:0002101) | 1.69518260 |
| 92 | Cerebral hypomyelination (HP:0006808) | 1.69308030 |
| 93 | Preaxial hand polydactyly (HP:0001177) | 1.68841553 |
| 94 | Prominent metopic ridge (HP:0005487) | 1.68242524 |
| 95 | Hypoplasia of the uterus (HP:0000013) | 1.67541252 |
| 96 | Abnormal urine phosphate concentration (HP:0012599) | 1.67273682 |
| 97 | Gait imbalance (HP:0002141) | 1.67250033 |
| 98 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.64764370 |
| 99 | Microvesicular hepatic steatosis (HP:0001414) | 1.63079873 |
| 100 | CNS hypomyelination (HP:0003429) | 1.62796344 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.36962509 |
| 2 | VRK2 | 4.09192797 |
| 3 | STK16 | 3.45363287 |
| 4 | MST4 | 2.65310042 |
| 5 | SRPK1 | 2.63810108 |
| 6 | NEK1 | 2.55747556 |
| 7 | PBK | 2.41144316 |
| 8 | EIF2AK1 | 2.32616927 |
| 9 | EIF2AK3 | 2.29857011 |
| 10 | LMTK2 | 2.28810837 |
| 11 | TRIM28 | 2.24559906 |
| 12 | NME1 | 2.24313486 |
| 13 | BRSK2 | 2.06397945 |
| 14 | ZAK | 1.98733335 |
| 15 | VRK1 | 1.88332692 |
| 16 | NME2 | 1.88279347 |
| 17 | PLK3 | 1.86904622 |
| 18 | LIMK1 | 1.73189834 |
| 19 | TTK | 1.71680912 |
| 20 | TESK1 | 1.65314338 |
| 21 | MAP3K12 | 1.63954474 |
| 22 | BCKDK | 1.60394792 |
| 23 | NUAK1 | 1.59307528 |
| 24 | TSSK6 | 1.58787598 |
| 25 | WEE1 | 1.58347061 |
| 26 | BRSK1 | 1.50769481 |
| 27 | CDC7 | 1.47900285 |
| 28 | PLK1 | 1.33884137 |
| 29 | PLK4 | 1.30324934 |
| 30 | BCR | 1.22499010 |
| 31 | PASK | 1.22371399 |
| 32 | BMPR1B | 1.20857424 |
| 33 | EPHA2 | 1.18035365 |
| 34 | TLK1 | 1.16287903 |
| 35 | WNK3 | 1.15827942 |
| 36 | MAP4K2 | 1.13721512 |
| 37 | CSNK1G1 | 1.06840532 |
| 38 | FRK | 1.06819768 |
| 39 | PIM2 | 1.06412214 |
| 40 | CSNK1G3 | 1.05640095 |
| 41 | ARAF | 1.03959302 |
| 42 | INSRR | 1.03397715 |
| 43 | CCNB1 | 0.92535114 |
| 44 | TAF1 | 0.91785032 |
| 45 | TNIK | 0.91731172 |
| 46 | CSNK1A1L | 0.91296939 |
| 47 | AURKB | 0.89484137 |
| 48 | ERBB3 | 0.89009472 |
| 49 | MST1R | 0.86834946 |
| 50 | PAK4 | 0.84645378 |
| 51 | TESK2 | 0.83066637 |
| 52 | PDK2 | 0.83064440 |
| 53 | AURKA | 0.82702489 |
| 54 | DYRK3 | 0.82429701 |
| 55 | PLK2 | 0.82212702 |
| 56 | STK38L | 0.81008440 |
| 57 | CSNK1G2 | 0.80702070 |
| 58 | DYRK2 | 0.79165142 |
| 59 | BRAF | 0.78913636 |
| 60 | STK3 | 0.78750496 |
| 61 | CDK8 | 0.76537338 |
| 62 | EIF2AK2 | 0.73999357 |
| 63 | MAP2K7 | 0.73865282 |
| 64 | PHKG2 | 0.73210358 |
| 65 | PHKG1 | 0.73210358 |
| 66 | MUSK | 0.73149967 |
| 67 | STK24 | 0.68113062 |
| 68 | ILK | 0.64216502 |
| 69 | PRKCI | 0.63757176 |
| 70 | STK4 | 0.63675583 |
| 71 | DAPK1 | 0.63522165 |
| 72 | MKNK2 | 0.63416203 |
| 73 | CASK | 0.63006843 |
| 74 | GRK1 | 0.60975127 |
| 75 | ERBB4 | 0.60912810 |
| 76 | CHEK2 | 0.60843810 |
| 77 | CSNK2A1 | 0.59587739 |
| 78 | MKNK1 | 0.58989394 |
| 79 | CSNK2A2 | 0.57669621 |
| 80 | NEK2 | 0.57631318 |
| 81 | ABL2 | 0.57167626 |
| 82 | MYLK | 0.56036972 |
| 83 | LRRK2 | 0.50584103 |
| 84 | ATR | 0.48231755 |
| 85 | PRKG2 | 0.48039180 |
| 86 | CDK7 | 0.47620050 |
| 87 | RPS6KA5 | 0.47083628 |
| 88 | PRKCE | 0.46707224 |
| 89 | FGFR1 | 0.45699055 |
| 90 | ATM | 0.45351146 |
| 91 | PAK1 | 0.44141881 |
| 92 | RPS6KA4 | 0.42841154 |
| 93 | CHEK1 | 0.42030546 |
| 94 | PRKCG | 0.39920656 |
| 95 | PINK1 | 0.39270790 |
| 96 | DAPK3 | 0.38758044 |
| 97 | MAPKAPK3 | 0.37353844 |
| 98 | STK10 | 0.37002647 |
| 99 | PAK3 | 0.36965625 |
| 100 | STK39 | 0.35537806 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.98916426 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.60985355 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.32517944 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.20014139 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.00190374 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.59282593 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.39633702 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.36654151 |
| 9 | Huntingtons disease_Homo sapiens_hsa05016 | 2.27266399 |
| 10 | Alzheimers disease_Homo sapiens_hsa05010 | 2.01857539 |
| 11 | DNA replication_Homo sapiens_hsa03030 | 2.00649212 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 1.97222417 |
| 13 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.96555913 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.82931385 |
| 15 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.76261981 |
| 16 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.76024299 |
| 17 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.75584013 |
| 18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.73353574 |
| 19 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.72687264 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.64034028 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.63501464 |
| 22 | Sulfur relay system_Homo sapiens_hsa04122 | 1.58931948 |
| 23 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.58395619 |
| 24 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.58320028 |
| 25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.58080844 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.53448484 |
| 27 | Spliceosome_Homo sapiens_hsa03040 | 1.51760036 |
| 28 | RNA transport_Homo sapiens_hsa03013 | 1.50259543 |
| 29 | Base excision repair_Homo sapiens_hsa03410 | 1.49967172 |
| 30 | Basal transcription factors_Homo sapiens_hsa03022 | 1.46259024 |
| 31 | RNA degradation_Homo sapiens_hsa03018 | 1.42819617 |
| 32 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.41056181 |
| 33 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.36389746 |
| 34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.35341249 |
| 35 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.33981127 |
| 36 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.33907956 |
| 37 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.30732297 |
| 38 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.30104538 |
| 39 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.27892130 |
| 40 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.20230384 |
| 41 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.16963003 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.14978327 |
| 43 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.13208291 |
| 44 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.12075189 |
| 45 | Purine metabolism_Homo sapiens_hsa00230 | 1.11056936 |
| 46 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.09937112 |
| 47 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.06729653 |
| 48 | Peroxisome_Homo sapiens_hsa04146 | 1.05185171 |
| 49 | Carbon metabolism_Homo sapiens_hsa01200 | 1.04862299 |
| 50 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.04519352 |
| 51 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.00329291 |
| 52 | Metabolic pathways_Homo sapiens_hsa01100 | 0.91169699 |
| 53 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.89946005 |
| 54 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.88700367 |
| 55 | Cell cycle_Homo sapiens_hsa04110 | 0.84830235 |
| 56 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.82441039 |
| 57 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.81521480 |
| 58 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.78612000 |
| 59 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.76827938 |
| 60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.76131537 |
| 61 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.76007159 |
| 62 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.75336045 |
| 63 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.75217969 |
| 64 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.74287409 |
| 65 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.71434401 |
| 66 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.69280408 |
| 67 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.66139554 |
| 68 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.63452438 |
| 69 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.63166323 |
| 70 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.60943318 |
| 71 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.60770622 |
| 72 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.59913578 |
| 73 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.58554899 |
| 74 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.57659213 |
| 75 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.53985699 |
| 76 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.53303894 |
| 77 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.51673381 |
| 78 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.51084187 |
| 79 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.50256237 |
| 80 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.50042938 |
| 81 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.49637028 |
| 82 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.47089347 |
| 83 | Circadian rhythm_Homo sapiens_hsa04710 | 0.43898795 |
| 84 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.43485800 |
| 85 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.42126232 |
| 86 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.40213464 |
| 87 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.39329734 |
| 88 | Galactose metabolism_Homo sapiens_hsa00052 | 0.39236382 |
| 89 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.39207153 |
| 90 | Retinol metabolism_Homo sapiens_hsa00830 | 0.39096485 |
| 91 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.36533648 |
| 92 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.36326930 |
| 93 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.34188680 |
| 94 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.33359048 |
| 95 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.25926758 |
| 96 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.25799727 |
| 97 | Mineral absorption_Homo sapiens_hsa04978 | 0.25192530 |
| 98 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.22325265 |
| 99 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.15781355 |
| 100 | Phototransduction_Homo sapiens_hsa04744 | 0.15379660 |

