TMEM99

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.82037437
2proteasome assembly (GO:0043248)5.47873986
3ATP synthesis coupled proton transport (GO:0015986)4.99154343
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.99154343
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.84566229
6chaperone-mediated protein transport (GO:0072321)4.63322644
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.61624806
8respiratory chain complex IV assembly (GO:0008535)4.30793391
9respiratory electron transport chain (GO:0022904)4.25833494
10electron transport chain (GO:0022900)4.16999650
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.12527451
12regulation of mitochondrial translation (GO:0070129)4.10807662
13protein complex biogenesis (GO:0070271)3.98518393
14regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.92530936
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.91440987
16rRNA modification (GO:0000154)3.91259367
17establishment of integrated proviral latency (GO:0075713)3.81606712
18mitochondrial respiratory chain complex assembly (GO:0033108)3.80544392
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.79235393
20negative regulation of ligase activity (GO:0051352)3.79235393
21protein targeting to mitochondrion (GO:0006626)3.77484219
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.75943863
23protein neddylation (GO:0045116)3.73648094
24cytochrome complex assembly (GO:0017004)3.70857628
25regulation of cellular amino acid metabolic process (GO:0006521)3.66022463
26ribosomal small subunit assembly (GO:0000028)3.64577687
27ribosomal large subunit biogenesis (GO:0042273)3.62865079
28NADH dehydrogenase complex assembly (GO:0010257)3.58698022
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58698022
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.58698022
31establishment of protein localization to mitochondrion (GO:0072655)3.50755617
32positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.48622642
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46692532
34termination of RNA polymerase III transcription (GO:0006386)3.45954502
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.45954502
36protein localization to mitochondrion (GO:0070585)3.41435548
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.39123800
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.39123800
39rRNA methylation (GO:0031167)3.38913719
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.38595041
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.38595041
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.38595041
43positive regulation of ligase activity (GO:0051351)3.33859089
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29689760
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.29689760
46water-soluble vitamin biosynthetic process (GO:0042364)3.29234148
47maturation of SSU-rRNA (GO:0030490)3.28589754
48establishment of viral latency (GO:0019043)3.27998258
49translation (GO:0006412)3.27637224
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27348353
51signal transduction involved in cell cycle checkpoint (GO:0072395)3.25445342
52ribosomal small subunit biogenesis (GO:0042274)3.25444938
53cotranslational protein targeting to membrane (GO:0006613)3.25116333
54cullin deneddylation (GO:0010388)3.24765496
55protein targeting to ER (GO:0045047)3.19343862
56peptidyl-histidine modification (GO:0018202)3.19093821
57regulation of ubiquitin-protein transferase activity (GO:0051438)3.16652222
58CENP-A containing nucleosome assembly (GO:0034080)3.15636713
59chromatin remodeling at centromere (GO:0031055)3.15608779
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13862921
61ribosome assembly (GO:0042255)3.12711622
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11817494
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08753332
64protein localization to endoplasmic reticulum (GO:0070972)3.07821781
65pseudouridine synthesis (GO:0001522)3.07027702
66cellular component biogenesis (GO:0044085)3.05843272
67regulation of ligase activity (GO:0051340)3.05590248
68protein deneddylation (GO:0000338)3.04602125
69oxidative phosphorylation (GO:0006119)3.04502594
70maturation of 5.8S rRNA (GO:0000460)3.01712488
71translational termination (GO:0006415)2.96231542
72viral transcription (GO:0019083)2.96117613
73purine nucleoside triphosphate biosynthetic process (GO:0009145)2.95711432
747-methylguanosine mRNA capping (GO:0006370)2.91760503
75mitochondrial transport (GO:0006839)2.90838688
76ATP biosynthetic process (GO:0006754)2.88242352
77ribonucleoprotein complex biogenesis (GO:0022613)2.88119054
78purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.87598825
79GTP biosynthetic process (GO:0006183)2.85560987
80transcription-coupled nucleotide-excision repair (GO:0006283)2.85556431
81mitotic metaphase plate congression (GO:0007080)2.85412444
82intracellular protein transmembrane import (GO:0044743)2.84757870
83rRNA processing (GO:0006364)2.83555565
847-methylguanosine RNA capping (GO:0009452)2.83026975
85RNA capping (GO:0036260)2.83026975
86translational initiation (GO:0006413)2.81026803
87spliceosomal snRNP assembly (GO:0000387)2.80919853
88inner mitochondrial membrane organization (GO:0007007)2.80900758
89lactate metabolic process (GO:0006089)2.79818020
90DNA damage response, detection of DNA damage (GO:0042769)2.78058401
91formation of translation preinitiation complex (GO:0001731)2.76542373
92negative regulation of protein ubiquitination (GO:0031397)2.73269981
93protein maturation by protein folding (GO:0022417)2.72804966
94rRNA metabolic process (GO:0016072)2.70512554
95DNA replication checkpoint (GO:0000076)2.68724178
96hydrogen ion transmembrane transport (GO:1902600)2.68392381
97ribonucleoside triphosphate biosynthetic process (GO:0009201)2.67732584
98transcription from mitochondrial promoter (GO:0006390)2.67509640
99regulation of cellular amine metabolic process (GO:0033238)2.66739701
100translational elongation (GO:0006414)2.65091048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.50815702
2* GABP_17652178_ChIP-ChIP_JURKAT_Human4.85789581
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.32716619
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.90335958
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.52338068
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.50458553
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.44966136
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42287531
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12025625
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.05667809
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02130356
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96100546
13* ELK1_19687146_ChIP-ChIP_HELA_Human2.83540006
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66889328
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63291752
16VDR_23849224_ChIP-Seq_CD4+_Human2.54335427
17DCP1A_22483619_ChIP-Seq_HELA_Human2.53751297
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52609675
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50830121
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50678165
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.49335717
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49220073
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.43010943
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29306461
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27073595
26FOXP3_21729870_ChIP-Seq_TREG_Human2.25495697
27E2F7_22180533_ChIP-Seq_HELA_Human2.21930450
28GABP_19822575_ChIP-Seq_HepG2_Human2.20469612
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18746640
30TTF2_22483619_ChIP-Seq_HELA_Human2.17187551
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14772117
32XRN2_22483619_ChIP-Seq_HELA_Human2.14377289
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08676639
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02785319
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93222423
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91214810
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88665710
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81035193
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71431073
40MYC_18940864_ChIP-ChIP_HL60_Human1.70871770
41AR_21909140_ChIP-Seq_LNCAP_Human1.70849057
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65211301
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64790052
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58039151
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.55807589
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.51991462
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51293372
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.50249136
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47833317
50KDM5A_27292631_Chip-Seq_BREAST_Human1.46596175
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45192954
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39824140
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39485203
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37825040
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32596200
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29752689
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27848217
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26710218
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25812366
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19968815
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.19518070
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14111083
63SOX17_20123909_ChIP-Seq_XEN_Mouse1.13737789
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13092463
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12894956
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11603645
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11504178
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.06377362
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06281827
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03593154
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03575968
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01972886
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98361379
74EWS_26573619_Chip-Seq_HEK293_Human0.97820602
75NOTCH1_21737748_ChIP-Seq_TLL_Human0.95731131
76ELF5_23300383_ChIP-Seq_T47D_Human0.95469331
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95348461
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94740690
79ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91953925
80TFEB_21752829_ChIP-Seq_HELA_Human0.90937379
81ZNF274_21170338_ChIP-Seq_K562_Hela0.90181620
82SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89689717
83VDR_22108803_ChIP-Seq_LS180_Human0.89263054
84SOX2_16153702_ChIP-ChIP_HESCs_Human0.87176302
85FUS_26573619_Chip-Seq_HEK293_Human0.85588721
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84509772
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83872389
88HTT_18923047_ChIP-ChIP_STHdh_Human0.81214222
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80991472
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78414325
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78379641
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77889748
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77212748
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76813949
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73683865
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73094403
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73076218
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.71372807
99CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70026736
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.68963499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.28702973
2MP0008058_abnormal_DNA_repair3.02040263
3MP0004957_abnormal_blastocyst_morpholog2.81558097
4MP0002163_abnormal_gland_morphology2.68184976
5MP0003806_abnormal_nucleotide_metabolis2.67786672
6MP0003186_abnormal_redox_activity2.65616961
7MP0003786_premature_aging2.64697266
8MP0009697_abnormal_copulation2.40580251
9MP0003195_calcinosis2.36643582
10MP0002938_white_spotting2.31096840
11MP0003111_abnormal_nucleus_morphology2.30947593
12MP0010030_abnormal_orbit_morphology2.30170989
13MP0010094_abnormal_chromosome_stability2.30158988
14MP0003718_maternal_effect2.20814603
15MP0003077_abnormal_cell_cycle2.10800745
16MP0008932_abnormal_embryonic_tissue2.06988711
17MP0006036_abnormal_mitochondrial_physio2.06515591
18MP0003123_paternal_imprinting2.03705232
19MP0006035_abnormal_mitochondrial_morpho1.94272849
20MP0009379_abnormal_foot_pigmentation1.87953400
21MP0000372_irregular_coat_pigmentation1.85493980
22MP0008007_abnormal_cellular_replicative1.79613789
23MP0005379_endocrine/exocrine_gland_phen1.69221840
24MP0006072_abnormal_retinal_apoptosis1.68889806
25MP0008789_abnormal_olfactory_epithelium1.66924611
26MP0003941_abnormal_skin_development1.59397776
27MP0001529_abnormal_vocalization1.58629422
28MP0005084_abnormal_gallbladder_morpholo1.55195935
29MP0006292_abnormal_olfactory_placode1.52945622
30MP0002160_abnormal_reproductive_system1.50088837
31MP0002132_abnormal_respiratory_system1.47338418
32MP0000358_abnormal_cell_content/1.45492926
33MP0002090_abnormal_vision1.42759842
34MP0001293_anophthalmia1.34219001
35MP0005408_hypopigmentation1.31057710
36MP0001661_extended_life_span1.29702370
37MP0008995_early_reproductive_senescence1.28702460
38MP0002233_abnormal_nose_morphology1.27908943
39MP0002277_abnormal_respiratory_mucosa1.27634032
40MP0002837_dystrophic_cardiac_calcinosis1.25032629
41MP0003937_abnormal_limbs/digits/tail_de1.24970033
42MP0001764_abnormal_homeostasis1.23995845
43MP0003136_yellow_coat_color1.19271981
44MP0005332_abnormal_amino_acid1.12022242
45MP0000647_abnormal_sebaceous_gland1.11564071
46MP0005389_reproductive_system_phenotype1.10450283
47MP0002210_abnormal_sex_determination1.08821755
48MP0003011_delayed_dark_adaptation1.06999559
49MP0003121_genomic_imprinting1.06832102
50MP0002102_abnormal_ear_morphology1.02521840
51MP0001984_abnormal_olfaction1.01895521
52MP0004133_heterotaxia1.01631135
53MP0001929_abnormal_gametogenesis0.99995647
54MP0003122_maternal_imprinting0.97075602
55MP0008877_abnormal_DNA_methylation0.96850488
56MP0005394_taste/olfaction_phenotype0.96195879
57MP0005499_abnormal_olfactory_system0.96195879
58MP0001542_abnormal_bone_strength0.95376144
59MP0005395_other_phenotype0.95338932
60MP0000049_abnormal_middle_ear0.94569473
61MP0005253_abnormal_eye_physiology0.92296705
62MP0001145_abnormal_male_reproductive0.92158650
63MP0005410_abnormal_fertilization0.91878476
64MP0002928_abnormal_bile_duct0.91566161
65MP0003315_abnormal_perineum_morphology0.91377576
66MP0002653_abnormal_ependyma_morphology0.89834175
67MP0000653_abnormal_sex_gland0.89558550
68MP0008875_abnormal_xenobiotic_pharmacok0.89333026
69MP0001697_abnormal_embryo_size0.87660440
70MP0002234_abnormal_pharynx_morphology0.86698298
71MP0001905_abnormal_dopamine_level0.84259927
72MP0008872_abnormal_physiological_respon0.83322965
73MP0003755_abnormal_palate_morphology0.82932753
74MP0001881_abnormal_mammary_gland0.82760183
75MP0005501_abnormal_skin_physiology0.82529031
76MP0010386_abnormal_urinary_bladder0.82279490
77MP0000350_abnormal_cell_proliferation0.81998352
78MP0002095_abnormal_skin_pigmentation0.81979319
79MP0001919_abnormal_reproductive_system0.81240709
80MP0004147_increased_porphyrin_level0.78180036
81MP0002177_abnormal_outer_ear0.77975650
82MP0002697_abnormal_eye_size0.77222852
83MP0001286_abnormal_eye_development0.76851510
84MP0000516_abnormal_urinary_system0.75582473
85MP0005367_renal/urinary_system_phenotyp0.75582473
86MP0004019_abnormal_vitamin_homeostasis0.74436599
87MP0002085_abnormal_embryonic_tissue0.73072418
88MP0001730_embryonic_growth_arrest0.73063362
89MP0005220_abnormal_exocrine_pancreas0.72796893
90MP0003698_abnormal_male_reproductive0.71238787
91MP0003950_abnormal_plasma_membrane0.70745690
92MP0003567_abnormal_fetal_cardiomyocyte0.70552788
93MP0005330_cardiomyopathy0.69506518
94MP0002282_abnormal_trachea_morphology0.69273370
95MP0003938_abnormal_ear_development0.68234250
96MP0001944_abnormal_pancreas_morphology0.67033901
97MP0002111_abnormal_tail_morphology0.66282301
98MP0004142_abnormal_muscle_tone0.65736795
99MP0002295_abnormal_pulmonary_circulatio0.65669378
100MP0003252_abnormal_bile_duct0.64533753

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.07352301
2Abnormal mitochondria in muscle tissue (HP:0008316)4.71119476
3Acute encephalopathy (HP:0006846)4.65727801
4Mitochondrial inheritance (HP:0001427)4.45391096
5Increased hepatocellular lipid droplets (HP:0006565)4.35471568
6Progressive macrocephaly (HP:0004481)4.26685046
7Increased CSF lactate (HP:0002490)4.20869376
8Renal Fanconi syndrome (HP:0001994)4.16628780
9Lipid accumulation in hepatocytes (HP:0006561)4.01749870
10Hepatocellular necrosis (HP:0001404)3.79705210
11Hepatic necrosis (HP:0002605)3.62223040
12Cerebral edema (HP:0002181)3.37868708
13Increased serum pyruvate (HP:0003542)3.04569045
14Increased serum lactate (HP:0002151)3.02703316
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01637649
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01637649
17Increased intramyocellular lipid droplets (HP:0012240)3.01012492
183-Methylglutaconic aciduria (HP:0003535)2.92181268
19Abnormality of glycolysis (HP:0004366)2.88140606
20Lactic acidosis (HP:0003128)2.87501000
21Exercise intolerance (HP:0003546)2.83822827
22Reticulocytopenia (HP:0001896)2.79912930
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77346536
24Abnormality of methionine metabolism (HP:0010901)2.75378633
25Abnormality of renal resorption (HP:0011038)2.74076210
26Type I transferrin isoform profile (HP:0003642)2.69598666
27Respiratory failure (HP:0002878)2.68142990
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55370899
29Macrocytic anemia (HP:0001972)2.48648548
30Hyperinsulinemic hypoglycemia (HP:0000825)2.48533534
31Methylmalonic acidemia (HP:0002912)2.47443231
32Increased muscle lipid content (HP:0009058)2.45899564
33Exertional dyspnea (HP:0002875)2.45552091
34Respiratory difficulties (HP:0002880)2.43348835
35Pancreatic fibrosis (HP:0100732)2.43086004
36Pancreatic cysts (HP:0001737)2.41859577
37Congenital, generalized hypertrichosis (HP:0004540)2.41807459
38Lethargy (HP:0001254)2.36281539
39Abnormality of cells of the erythroid lineage (HP:0012130)2.36254383
40True hermaphroditism (HP:0010459)2.33684114
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32210813
42Hyperphosphaturia (HP:0003109)2.32202730
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.31114604
44Glycosuria (HP:0003076)2.28765585
45Abnormality of urine glucose concentration (HP:0011016)2.28765585
46Abnormal number of erythroid precursors (HP:0012131)2.28657165
47Leukodystrophy (HP:0002415)2.27026840
48Hyperglycinemia (HP:0002154)2.26478628
49Sensory axonal neuropathy (HP:0003390)2.22055093
50Sparse eyelashes (HP:0000653)2.21518672
51Methylmalonic aciduria (HP:0012120)2.18746216
52Hypoglycemic coma (HP:0001325)2.17830237
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16835444
54Abnormal protein N-linked glycosylation (HP:0012347)2.16835444
55Abnormal protein glycosylation (HP:0012346)2.16835444
56Abnormal glycosylation (HP:0012345)2.16835444
57Medial flaring of the eyebrow (HP:0010747)2.10077794
58Adrenal hypoplasia (HP:0000835)2.08859448
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05845104
60Abnormality of serum amino acid levels (HP:0003112)2.04611396
61Optic disc pallor (HP:0000543)2.02522479
62Sclerocornea (HP:0000647)2.02346781
63Entropion (HP:0000621)2.00490804
64Gout (HP:0001997)1.99962388
65Reduced antithrombin III activity (HP:0001976)1.98510642
66CNS demyelination (HP:0007305)1.97151756
67X-linked dominant inheritance (HP:0001423)1.96852748
68Molar tooth sign on MRI (HP:0002419)1.96449849
69Abnormality of midbrain morphology (HP:0002418)1.96449849
70Meckel diverticulum (HP:0002245)1.93516618
71Abnormality of the anterior horn cell (HP:0006802)1.91134282
72Degeneration of anterior horn cells (HP:0002398)1.91134282
73Hypoplastic pelvis (HP:0008839)1.89359594
74Megaloblastic anemia (HP:0001889)1.89159721
75Absent thumb (HP:0009777)1.84216150
76Delayed CNS myelination (HP:0002188)1.83076731
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82537706
78Abnormality of alanine metabolism (HP:0010916)1.82537706
79Hyperalaninemia (HP:0003348)1.82537706
80Abnormality of the ileum (HP:0001549)1.81778885
81Congenital primary aphakia (HP:0007707)1.81289784
82Abnormality of the preputium (HP:0100587)1.80341373
83Horseshoe kidney (HP:0000085)1.79769904
84Rough bone trabeculation (HP:0100670)1.79004785
85Hypoglycemic seizures (HP:0002173)1.78214480
86Aplasia/hypoplasia of the uterus (HP:0008684)1.77989458
87Median cleft lip (HP:0000161)1.77018724
88Nephrogenic diabetes insipidus (HP:0009806)1.75820416
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.72283958
90Renal tubular dysfunction (HP:0000124)1.70931976
91Abnormal lung lobation (HP:0002101)1.69518260
92Cerebral hypomyelination (HP:0006808)1.69308030
93Preaxial hand polydactyly (HP:0001177)1.68841553
94Prominent metopic ridge (HP:0005487)1.68242524
95Hypoplasia of the uterus (HP:0000013)1.67541252
96Abnormal urine phosphate concentration (HP:0012599)1.67273682
97Gait imbalance (HP:0002141)1.67250033
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.64764370
99Microvesicular hepatic steatosis (HP:0001414)1.63079873
100CNS hypomyelination (HP:0003429)1.62796344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.36962509
2VRK24.09192797
3STK163.45363287
4MST42.65310042
5SRPK12.63810108
6NEK12.55747556
7PBK2.41144316
8EIF2AK12.32616927
9EIF2AK32.29857011
10LMTK22.28810837
11TRIM282.24559906
12NME12.24313486
13BRSK22.06397945
14ZAK1.98733335
15VRK11.88332692
16NME21.88279347
17PLK31.86904622
18LIMK11.73189834
19TTK1.71680912
20TESK11.65314338
21MAP3K121.63954474
22BCKDK1.60394792
23NUAK11.59307528
24TSSK61.58787598
25WEE11.58347061
26BRSK11.50769481
27CDC71.47900285
28PLK11.33884137
29PLK41.30324934
30BCR1.22499010
31PASK1.22371399
32BMPR1B1.20857424
33EPHA21.18035365
34TLK11.16287903
35WNK31.15827942
36MAP4K21.13721512
37CSNK1G11.06840532
38FRK1.06819768
39PIM21.06412214
40CSNK1G31.05640095
41ARAF1.03959302
42INSRR1.03397715
43CCNB10.92535114
44TAF10.91785032
45TNIK0.91731172
46CSNK1A1L0.91296939
47AURKB0.89484137
48ERBB30.89009472
49MST1R0.86834946
50PAK40.84645378
51TESK20.83066637
52PDK20.83064440
53AURKA0.82702489
54DYRK30.82429701
55PLK20.82212702
56STK38L0.81008440
57CSNK1G20.80702070
58DYRK20.79165142
59BRAF0.78913636
60STK30.78750496
61CDK80.76537338
62EIF2AK20.73999357
63MAP2K70.73865282
64PHKG20.73210358
65PHKG10.73210358
66MUSK0.73149967
67STK240.68113062
68ILK0.64216502
69PRKCI0.63757176
70STK40.63675583
71DAPK10.63522165
72MKNK20.63416203
73CASK0.63006843
74GRK10.60975127
75ERBB40.60912810
76CHEK20.60843810
77CSNK2A10.59587739
78MKNK10.58989394
79CSNK2A20.57669621
80NEK20.57631318
81ABL20.57167626
82MYLK0.56036972
83LRRK20.50584103
84ATR0.48231755
85PRKG20.48039180
86CDK70.47620050
87RPS6KA50.47083628
88PRKCE0.46707224
89FGFR10.45699055
90ATM0.45351146
91PAK10.44141881
92RPS6KA40.42841154
93CHEK10.42030546
94PRKCG0.39920656
95PINK10.39270790
96DAPK30.38758044
97MAPKAPK30.37353844
98STK100.37002647
99PAK30.36965625
100STK390.35537806

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.98916426
2Oxidative phosphorylation_Homo sapiens_hsa001903.60985355
3Ribosome_Homo sapiens_hsa030103.32517944
4Protein export_Homo sapiens_hsa030603.20014139
5Parkinsons disease_Homo sapiens_hsa050123.00190374
6RNA polymerase_Homo sapiens_hsa030202.59282593
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39633702
8Mismatch repair_Homo sapiens_hsa034302.36654151
9Huntingtons disease_Homo sapiens_hsa050162.27266399
10Alzheimers disease_Homo sapiens_hsa050102.01857539
11DNA replication_Homo sapiens_hsa030302.00649212
12Homologous recombination_Homo sapiens_hsa034401.97222417
13Fatty acid elongation_Homo sapiens_hsa000621.96555913
14Nucleotide excision repair_Homo sapiens_hsa034201.82931385
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76261981
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76024299
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.75584013
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73353574
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72687264
20Pyrimidine metabolism_Homo sapiens_hsa002401.64034028
21Propanoate metabolism_Homo sapiens_hsa006401.63501464
22Sulfur relay system_Homo sapiens_hsa041221.58931948
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58395619
24Folate biosynthesis_Homo sapiens_hsa007901.58320028
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58080844
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53448484
27Spliceosome_Homo sapiens_hsa030401.51760036
28RNA transport_Homo sapiens_hsa030131.50259543
29Base excision repair_Homo sapiens_hsa034101.49967172
30Basal transcription factors_Homo sapiens_hsa030221.46259024
31RNA degradation_Homo sapiens_hsa030181.42819617
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41056181
33Glutathione metabolism_Homo sapiens_hsa004801.36389746
34Pyruvate metabolism_Homo sapiens_hsa006201.35341249
35Fanconi anemia pathway_Homo sapiens_hsa034601.33981127
36Vitamin B6 metabolism_Homo sapiens_hsa007501.33907956
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.30732297
38One carbon pool by folate_Homo sapiens_hsa006701.30104538
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.27892130
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20230384
41Non-homologous end-joining_Homo sapiens_hsa034501.16963003
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14978327
43Steroid biosynthesis_Homo sapiens_hsa001001.13208291
44Cardiac muscle contraction_Homo sapiens_hsa042601.12075189
45Purine metabolism_Homo sapiens_hsa002301.11056936
46Butanoate metabolism_Homo sapiens_hsa006501.09937112
47Selenocompound metabolism_Homo sapiens_hsa004501.06729653
48Peroxisome_Homo sapiens_hsa041461.05185171
49Carbon metabolism_Homo sapiens_hsa012001.04862299
50Sulfur metabolism_Homo sapiens_hsa009201.04519352
51Biosynthesis of amino acids_Homo sapiens_hsa012301.00329291
52Metabolic pathways_Homo sapiens_hsa011000.91169699
53N-Glycan biosynthesis_Homo sapiens_hsa005100.89946005
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88700367
55Cell cycle_Homo sapiens_hsa041100.84830235
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82441039
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81521480
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.78612000
59Collecting duct acid secretion_Homo sapiens_hsa049660.76827938
60Regulation of autophagy_Homo sapiens_hsa041400.76131537
61Fatty acid metabolism_Homo sapiens_hsa012120.76007159
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75336045
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75217969
64beta-Alanine metabolism_Homo sapiens_hsa004100.74287409
65Vibrio cholerae infection_Homo sapiens_hsa051100.71434401
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69280408
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66139554
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63452438
69Arginine and proline metabolism_Homo sapiens_hsa003300.63166323
70Fatty acid degradation_Homo sapiens_hsa000710.60943318
71Oocyte meiosis_Homo sapiens_hsa041140.60770622
72Chemical carcinogenesis_Homo sapiens_hsa052040.59913578
73Tyrosine metabolism_Homo sapiens_hsa003500.58554899
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57659213
75p53 signaling pathway_Homo sapiens_hsa041150.53985699
76Fructose and mannose metabolism_Homo sapiens_hsa000510.53303894
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51673381
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51084187
79Tryptophan metabolism_Homo sapiens_hsa003800.50256237
80Phenylalanine metabolism_Homo sapiens_hsa003600.50042938
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49637028
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.47089347
83Circadian rhythm_Homo sapiens_hsa047100.43898795
84Vitamin digestion and absorption_Homo sapiens_hsa049770.43485800
85mRNA surveillance pathway_Homo sapiens_hsa030150.42126232
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40213464
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39329734
88Galactose metabolism_Homo sapiens_hsa000520.39236382
89Pentose phosphate pathway_Homo sapiens_hsa000300.39207153
90Retinol metabolism_Homo sapiens_hsa008300.39096485
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.36533648
92Nitrogen metabolism_Homo sapiens_hsa009100.36326930
93Caffeine metabolism_Homo sapiens_hsa002320.34188680
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33359048
95Arginine biosynthesis_Homo sapiens_hsa002200.25926758
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.25799727
97Mineral absorption_Homo sapiens_hsa049780.25192530
98Hedgehog signaling pathway_Homo sapiens_hsa043400.22325265
99Basal cell carcinoma_Homo sapiens_hsa052170.15781355
100Phototransduction_Homo sapiens_hsa047440.15379660

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