TMEM9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.09568031
2axon ensheathment in central nervous system (GO:0032291)6.09568031
3fatty acid elongation (GO:0030497)4.48972872
4long-chain fatty acid biosynthetic process (GO:0042759)3.59490085
5neuronal action potential propagation (GO:0019227)3.43756836
6myelination (GO:0042552)3.41761435
7L-amino acid import (GO:0043092)3.41661188
8axon ensheathment (GO:0008366)3.38931680
9ensheathment of neurons (GO:0007272)3.38931680
10negative regulation of neurotransmitter transport (GO:0051589)3.15760977
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09934560
12synaptic vesicle exocytosis (GO:0016079)3.08572642
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04580294
14negative regulation of cell killing (GO:0031342)3.04580294
15synaptic vesicle maturation (GO:0016188)3.00804711
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.97494230
17cellular potassium ion homeostasis (GO:0030007)2.97357840
18response to methylmercury (GO:0051597)2.96954667
19regulation of amyloid precursor protein catabolic process (GO:1902991)2.93309182
20negative regulation of neurotransmitter secretion (GO:0046929)2.88455950
21substantia nigra development (GO:0021762)2.86228191
22antigen processing and presentation of endogenous antigen (GO:0019883)2.83474824
23Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82296946
24cellular copper ion homeostasis (GO:0006878)2.77856398
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.76424185
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75877321
27amino acid import (GO:0043090)2.75687253
28negative regulation of protein localization to cell surface (GO:2000009)2.73159221
29regulation of synaptic vesicle exocytosis (GO:2000300)2.72421377
30oligodendrocyte differentiation (GO:0048709)2.68564185
31glycosylceramide metabolic process (GO:0006677)2.65219435
32amyloid precursor protein metabolic process (GO:0042982)2.62941742
33myelin maintenance (GO:0043217)2.59943894
34neuron cell-cell adhesion (GO:0007158)2.59779090
35negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59593888
36actin nucleation (GO:0045010)2.58818256
37regulation of synaptic vesicle transport (GO:1902803)2.58038969
38response to redox state (GO:0051775)2.56979533
39immunoglobulin mediated immune response (GO:0016064)2.56877709
40positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.56159728
41neutrophil activation involved in immune response (GO:0002283)2.53924018
42regulation of neuron projection regeneration (GO:0070570)2.53072721
43regulation of axon regeneration (GO:0048679)2.53072721
44regulation of beta-amyloid formation (GO:1902003)2.51636259
45presynaptic membrane organization (GO:0097090)2.50498561
46regulation of collateral sprouting (GO:0048670)2.50449325
47phagosome maturation (GO:0090382)2.49407001
48glycosphingolipid catabolic process (GO:0046479)2.49183116
49granulocyte activation (GO:0036230)2.48813167
50presynaptic membrane assembly (GO:0097105)2.47507802
51positive regulation of cellular amide metabolic process (GO:0034250)2.47303770
52glutamate secretion (GO:0014047)2.47102892
53cholesterol biosynthetic process (GO:0006695)2.45634199
54neutrophil activation (GO:0042119)2.44073321
55transmission of nerve impulse (GO:0019226)2.43099141
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.42520049
57adult walking behavior (GO:0007628)2.41709501
58eosinophil chemotaxis (GO:0048245)2.41615434
59energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.41595156
60ATP hydrolysis coupled proton transport (GO:0015991)2.41595156
61barbed-end actin filament capping (GO:0051016)2.41591630
62cellular response to thyroid hormone stimulus (GO:0097067)2.41276222
63magnesium ion transport (GO:0015693)2.41141406
64potassium ion import (GO:0010107)2.40752426
65neuron remodeling (GO:0016322)2.39181902
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.38868352
67transferrin transport (GO:0033572)2.36745553
68glycolipid catabolic process (GO:0019377)2.34973850
69signal peptide processing (GO:0006465)2.32607353
70creatine metabolic process (GO:0006600)2.31856458
71regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31693197
72long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.31083969
73regulation of neuronal synaptic plasticity (GO:0048168)2.30100588
74long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.29620285
75gamma-aminobutyric acid signaling pathway (GO:0007214)2.29580688
76copper ion homeostasis (GO:0055070)2.29118532
77regulation of integrin-mediated signaling pathway (GO:2001044)2.27687567
78GPI anchor biosynthetic process (GO:0006506)2.27416847
79neurotransmitter uptake (GO:0001504)2.26752778
80positive regulation of monocyte chemotaxis (GO:0090026)2.25974580
81protein localization to synapse (GO:0035418)2.25223268
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.24864208
83negative regulation of interleukin-17 production (GO:0032700)2.24254859
84negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.23706878
85bone resorption (GO:0045453)2.23359679
86regulation of long-term neuronal synaptic plasticity (GO:0048169)2.23323356
87mast cell activation (GO:0045576)2.23013789
88regulation of voltage-gated calcium channel activity (GO:1901385)2.22382219
89amino sugar catabolic process (GO:0046348)2.22316555
90ionotropic glutamate receptor signaling pathway (GO:0035235)2.20855076
91detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.20191408
92detection of temperature stimulus involved in sensory perception (GO:0050961)2.20191408
93vocalization behavior (GO:0071625)2.19692429
94sterol biosynthetic process (GO:0016126)2.19416612
95COPI coating of Golgi vesicle (GO:0048205)2.19148193
96Golgi transport vesicle coating (GO:0048200)2.19148193
97trivalent inorganic cation transport (GO:0072512)2.19024149
98ferric iron transport (GO:0015682)2.19024149
99macrophage activation involved in immune response (GO:0002281)2.18540843
100amyloid precursor protein catabolic process (GO:0042987)2.17794127
101positive regulation of leukocyte degranulation (GO:0043302)2.17139917
102locomotory exploration behavior (GO:0035641)2.16917721
103virion attachment to host cell (GO:0019062)2.16346310
104adhesion of symbiont to host cell (GO:0044650)2.16346310
105negative regulation of interleukin-12 production (GO:0032695)2.15603320
106eosinophil migration (GO:0072677)2.15453909
107regulation of autophagic vacuole assembly (GO:2000785)2.15428352
108regulation of T-helper 2 cell differentiation (GO:0045628)2.15209281
109interferon-gamma-mediated signaling pathway (GO:0060333)2.15118857
110chaperone-mediated protein transport (GO:0072321)2.14790745
111positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.14625184
112positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.13712367
113establishment of mitochondrion localization (GO:0051654)2.13599454
114glutamate receptor signaling pathway (GO:0007215)2.13445036
115regulation of defense response to virus by virus (GO:0050690)2.12827228
116regulated secretory pathway (GO:0045055)2.12240856
117long-term synaptic potentiation (GO:0060291)2.12092036
118potassium ion homeostasis (GO:0055075)2.11709913
119oligosaccharide catabolic process (GO:0009313)2.11239231
120response to peptidoglycan (GO:0032494)2.10910141
121axon development (GO:0061564)2.09852430
122acidic amino acid transport (GO:0015800)2.09710863
123peptidyl-tyrosine autophosphorylation (GO:0038083)2.09463469
124negative regulation of axonogenesis (GO:0050771)2.09183003
125L-glutamate transport (GO:0015813)2.08878382
126mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.08542964
127peptide catabolic process (GO:0043171)2.08363751
128adenosine receptor signaling pathway (GO:0001973)2.08229912
129regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.07467195
130protein palmitoylation (GO:0018345)2.07120907
131response to epinephrine (GO:0071871)2.07005193
132GPI anchor metabolic process (GO:0006505)2.06460700
133eye photoreceptor cell differentiation (GO:0001754)2.06023816
134photoreceptor cell differentiation (GO:0046530)2.06023816
135detection of other organism (GO:0098543)2.05854904
136negative regulation of lipid storage (GO:0010888)2.05844070
137regulation of interferon-beta biosynthetic process (GO:0045357)2.05740080
138positive regulation of type 2 immune response (GO:0002830)2.05677120
139leukocyte migration involved in inflammatory response (GO:0002523)2.05593877
140import into cell (GO:0098657)2.05317178
141fat-soluble vitamin biosynthetic process (GO:0042362)2.04497402
142negative regulation of glycoprotein metabolic process (GO:1903019)2.02799125
143ceramide catabolic process (GO:0046514)2.02097669
144positive regulation of mast cell activation (GO:0033005)2.00340813
145sphingosine metabolic process (GO:0006670)2.00032064
146negative regulation of macrophage derived foam cell differentiation (GO:0010745)1.98232634
147fibril organization (GO:0097435)1.98009672
148regulation of antigen processing and presentation of peptide antigen (GO:0002583)1.97718100
149serine transport (GO:0032329)1.97156354
150positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)1.96557008
151regulation of type 2 immune response (GO:0002828)1.96542970
152regulation of mononuclear cell migration (GO:0071675)1.95541902
153positive regulation of gamma-delta T cell activation (GO:0046645)1.94263364
154positive regulation of interleukin-1 beta secretion (GO:0050718)1.92873509
155positive regulation of macrophage differentiation (GO:0045651)1.91984359
156cellular response to arsenic-containing substance (GO:0071243)1.91844002
157lipopolysaccharide-mediated signaling pathway (GO:0031663)1.91439089
158regulation of regulatory T cell differentiation (GO:0045589)1.90948450
159negative regulation of glycoprotein biosynthetic process (GO:0010561)1.90256641
160regulation of T cell tolerance induction (GO:0002664)1.89701525
161detection of bacterium (GO:0016045)1.89087405
162regulation of fever generation (GO:0031620)1.88990634
163alpha-linolenic acid metabolic process (GO:0036109)1.88782737
164N-acetylneuraminate metabolic process (GO:0006054)1.88520150
165type I interferon signaling pathway (GO:0060337)1.88510202
166cellular response to type I interferon (GO:0071357)1.88510202
167negative regulation of inflammatory response to antigenic stimulus (GO:0002862)1.88482643
168regulation of metalloenzyme activity (GO:0048552)1.88179271
169L-serine transport (GO:0015825)1.87688327
170macrophage activation (GO:0042116)1.87610274
171regulation of interleukin-17 production (GO:0032660)1.87566481
172macroautophagy (GO:0016236)1.86982871
173negative regulation of lymphocyte mediated immunity (GO:0002707)1.86775178
174protein localization to endosome (GO:0036010)1.86262821
175iron ion transport (GO:0006826)1.86171462
176diol metabolic process (GO:0034311)1.85729837
177T-helper 1 type immune response (GO:0042088)1.85391669
178lymphocyte chemotaxis (GO:0048247)1.84686844
179positive regulation of cholesterol transport (GO:0032376)1.84056398
180positive regulation of sterol transport (GO:0032373)1.84056398
181membrane lipid catabolic process (GO:0046466)1.83999358
182angiotensin maturation (GO:0002003)1.83977692
183regulation of monocyte chemotaxis (GO:0090025)1.83240720
184response to thyroid hormone (GO:0097066)1.83212438
185regulation of receptor recycling (GO:0001919)1.83163311
186regulation of mast cell degranulation (GO:0043304)1.82938200
187positive regulation of interleukin-1 secretion (GO:0050716)1.82876049
188response to type I interferon (GO:0034340)1.82359528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.69935515
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64421937
3GBX2_23144817_ChIP-Seq_PC3_Human2.58397895
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53280489
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44850314
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44019295
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27793714
8* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21288526
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20551343
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20303099
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19481028
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11927728
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10134757
14RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93537630
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93537630
16SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91287239
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90638703
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89389610
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88393014
20MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86578430
21* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86284770
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86186005
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84760060
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.81232045
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.79791866
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77872373
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75956654
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75722566
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74917496
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73975934
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73177563
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67242006
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63266909
34AR_21572438_ChIP-Seq_LNCaP_Human1.62265487
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.60872856
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56823636
37REST_21632747_ChIP-Seq_MESCs_Mouse1.56583815
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54033080
39VDR_24787735_ChIP-Seq_THP-1_Human1.51356799
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50250445
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.46156591
42DROSHA_22980978_ChIP-Seq_HELA_Human1.43929766
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42533393
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42310515
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41462439
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.41450865
47TAF15_26573619_Chip-Seq_HEK293_Human1.41070077
48VDR_22108803_ChIP-Seq_LS180_Human1.38138328
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.34454273
50ER_23166858_ChIP-Seq_MCF-7_Human1.33340547
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.31028528
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.29723131
53SPI1_23127762_ChIP-Seq_K562_Human1.29363481
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21397148
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21115303
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21097381
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21097381
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21035743
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20972652
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19803070
61P300_19829295_ChIP-Seq_ESCs_Human1.19279562
62JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14027854
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13015855
64* SPI1_23547873_ChIP-Seq_NB4_Human1.12442745
65RUNX_20019798_ChIP-Seq_JUKART_Human1.11769566
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09670083
67GATA1_19941826_ChIP-Seq_K562_Human1.09641556
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.09342898
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09329768
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09176352
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08945044
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07798604
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.07345483
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07321803
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.07039689
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06308047
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05995626
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03610947
79* MYB_26560356_Chip-Seq_TH2_Human1.02897330
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02643510
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02404011
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02056902
83CJUN_26792858_Chip-Seq_BT549_Human1.01318407
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00294794
85* SMAD4_21799915_ChIP-Seq_A2780_Human0.99407720
86IGF1R_20145208_ChIP-Seq_DFB_Human0.99197630
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99196078
88RUNX1_22412390_ChIP-Seq_EML_Mouse0.98352372
89IRF8_27001747_Chip-Seq_BMDM_Mouse0.97495399
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95903551
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.95617660
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94375111
93AR_25329375_ChIP-Seq_VCAP_Human0.93710050
94SOX2_20726797_ChIP-Seq_SW620_Human0.93707433
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93500458
96RXR_22158963_ChIP-Seq_LIVER_Mouse0.93470589
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92268755
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91744692
99BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91315221
100GATA3_27048872_Chip-Seq_THYMUS_Human0.91108365
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.90197798
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89587169
103KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89556810
104HTT_18923047_ChIP-ChIP_STHdh_Human0.89299142
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89000204
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88968791
107STAT1_20625510_ChIP-Seq_HELA_Human0.88748738
108SMAD3_21741376_ChIP-Seq_EPCs_Human0.87804073
109GATA2_19941826_ChIP-Seq_K562_Human0.86850562
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86502346
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86493615
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86015940
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85986644
114RXR_22108803_ChIP-Seq_LS180_Human0.85867255
115TFEB_21752829_ChIP-Seq_HELA_Human0.85686662
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85683119
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85683119
118TP53_18474530_ChIP-ChIP_U2OS_Human0.85444204
119IRF8_22096565_ChIP-ChIP_GC-B_Human0.85316033
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85086544
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85052237
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84380388
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84234833
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83948139
125NANOG_19829295_ChIP-Seq_ESCs_Human0.83771151
126SOX2_19829295_ChIP-Seq_ESCs_Human0.83771151
127SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83503896
128RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83385460
129PU_27001747_Chip-Seq_BMDM_Mouse0.83259887
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82553630
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82424700
132EGR1_19032775_ChIP-ChIP_M12_Human0.82292958
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.82250964
134TAL1_26923725_Chip-Seq_HPCs_Mouse0.82130531
135GATA3_26560356_Chip-Seq_TH2_Human0.81970327
136TP63_23658742_ChIP-Seq_EP156T_Human0.81420890
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81397992
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.80945492
139DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80594576
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80452809
141MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.79444508
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.78998258
143VDR_24763502_ChIP-Seq_THP-1_Human0.78839560
144NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78679003
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78350163
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77627651
147JUN_21703547_ChIP-Seq_K562_Human0.77593142
148SMAD_19615063_ChIP-ChIP_OVARY_Human0.77482856
149E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77331443
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.77138356
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77060572
152ZNF274_21170338_ChIP-Seq_K562_Hela0.77024965
153CLOCK_20551151_ChIP-Seq_293T_Human0.76787223
154ESR2_21235772_ChIP-Seq_MCF-7_Human0.76376799
155SUZ12_18555785_Chip-Seq_ESCs_Mouse0.75414869
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75305115
157KDM2B_26808549_Chip-Seq_REH_Human0.75069918
158CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75020783
159SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74846588
160EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.74649845
161PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74554453
162TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.74465241
163P53_22387025_ChIP-Seq_ESCs_Mouse0.74157167
164LXR_22158963_ChIP-Seq_LIVER_Mouse0.73812460
165ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73288824
166EOMES_21245162_ChIP-Seq_HESCs_Human0.73155833
167RING1B_27294783_Chip-Seq_ESCs_Mouse0.71377643
168CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71185771
169BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70850155
170TP63_17297297_ChIP-ChIP_HaCaT_Human0.70631136
171GATA1_22025678_ChIP-Seq_K562_Human0.69958658
172* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67533880
173SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67352004
174SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67197761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.84440579
2MP0000920_abnormal_myelination3.63127285
3MP0004859_abnormal_synaptic_plasticity3.56587217
4MP0003329_amyloid_beta_deposits3.24095751
5MP0003191_abnormal_cellular_cholesterol3.10433387
6MP0004270_analgesia2.77163995
7MP0003690_abnormal_glial_cell2.51582975
8MP0002064_seizures2.50348495
9MP0003635_abnormal_synaptic_transmissio2.47263006
10MP0003436_decreased_susceptibility_to2.41051325
11MP0002272_abnormal_nervous_system2.32348635
12MP0003303_peritoneal_inflammation2.25105122
13MP0009745_abnormal_behavioral_response2.21771090
14MP0001529_abnormal_vocalization2.19105188
15MP0005464_abnormal_platelet_physiology2.16262521
16MP0000604_amyloidosis2.14816645
17MP0001905_abnormal_dopamine_level2.14448859
18MP0009046_muscle_twitch2.07290002
19MP0001486_abnormal_startle_reflex2.04465744
20MP0000343_altered_response_to2.02221738
21MP0000465_gastrointestinal_hemorrhage2.02158494
22MP0005058_abnormal_lysosome_morphology1.95119236
23MP0002063_abnormal_learning/memory/cond1.94980171
24MP0001968_abnormal_touch/_nociception1.91816609
25MP0002734_abnormal_mechanical_nocicepti1.91654124
26MP0005171_absent_coat_pigmentation1.87840512
27MP0003300_gastrointestinal_ulcer1.85185179
28MP0004510_myositis1.81941514
29MP0002735_abnormal_chemical_nociception1.80193928
30MP0002736_abnormal_nociception_after1.79851898
31MP0004142_abnormal_muscle_tone1.76653955
32MP0002572_abnormal_emotion/affect_behav1.72394934
33MP0003634_abnormal_glial_cell1.71335990
34MP0001970_abnormal_pain_threshold1.69331132
35MP0002822_catalepsy1.67383923
36MP0004742_abnormal_vestibular_system1.64761797
37MP0003806_abnormal_nucleotide_metabolis1.64531808
38MP0006082_CNS_inflammation1.61026059
39MP0009764_decreased_sensitivity_to1.60850891
40MP0001440_abnormal_grooming_behavior1.59006478
41MP0000685_abnormal_immune_system1.57092778
42MP0003633_abnormal_nervous_system1.56221600
43MP0008569_lethality_at_weaning1.55718849
44MP0010155_abnormal_intestine_physiology1.55691908
45MP0001501_abnormal_sleep_pattern1.54784028
46MP0002733_abnormal_thermal_nociception1.54559542
47MP0002452_abnormal_antigen_presenting1.51667857
48MP0003075_altered_response_to1.49765422
49MP0004885_abnormal_endolymph1.48318616
50MP0004858_abnormal_nervous_system1.45050850
51MP0002067_abnormal_sensory_capabilities1.44738866
52MP0002148_abnormal_hypersensitivity_rea1.43264604
53MP0001845_abnormal_inflammatory_respons1.41092150
54MP0002229_neurodegeneration1.40673794
55MP0000372_irregular_coat_pigmentation1.39598214
56MP0010386_abnormal_urinary_bladder1.38227105
57MP0003631_nervous_system_phenotype1.38098012
58MP0004043_abnormal_pH_regulation1.36478128
59MP0001800_abnormal_humoral_immune1.35806528
60MP0002139_abnormal_hepatobiliary_system1.34729862
61MP0003724_increased_susceptibility_to1.34656232
62MP0001542_abnormal_bone_strength1.33878642
63MP0005671_abnormal_response_to1.33177126
64MP0004147_increased_porphyrin_level1.32382224
65MP0004947_skin_inflammation1.32284212
66MP0002998_abnormal_bone_remodeling1.32229550
67MP0005423_abnormal_somatic_nervous1.30762383
68MP0003183_abnormal_peptide_metabolism1.24651696
69MP0003632_abnormal_nervous_system1.22980561
70MP0005386_behavior/neurological_phenoty1.22584026
71MP0004924_abnormal_behavior1.22584026
72MP0009785_altered_susceptibility_to1.20616580
73MP0008469_abnormal_protein_level1.20296418
74MP0002405_respiratory_system_inflammati1.18841229
75MP0003448_altered_tumor_morphology1.17819975
76MP0005000_abnormal_immune_tolerance1.17476056
77MP0003866_abnormal_defecation1.16701759
78MP0003172_abnormal_lysosome_physiology1.15380638
79MP0001958_emphysema1.15165421
80MP0001485_abnormal_pinna_reflex1.15112270
81MP0001984_abnormal_olfaction1.14331969
82MP0002419_abnormal_innate_immunity1.11068000
83MP0005365_abnormal_bile_salt1.09102017
84MP0008260_abnormal_autophagy1.09050268
85MP0002066_abnormal_motor_capabilities/c1.08279356
86MP0001853_heart_inflammation1.08007922
87MP0005310_abnormal_salivary_gland1.07022432
88MP0005410_abnormal_fertilization1.05698885
89MP0002332_abnormal_exercise_endurance1.05232643
90MP0004883_abnormal_blood_vessel1.04953514
91MP0001502_abnormal_circadian_rhythm1.04896969
92MP0003656_abnormal_erythrocyte_physiolo1.04419797
93MP0000778_abnormal_nervous_system1.03870195
94MP0003828_pulmonary_edema1.03851750
95MP0001835_abnormal_antigen_presentation1.03434677
96MP0006054_spinal_hemorrhage1.02327415
97MP0005164_abnormal_response_to1.01373723
98MP0002090_abnormal_vision1.00754771
99MP0003950_abnormal_plasma_membrane1.00702342
100MP0005646_abnormal_pituitary_gland1.00466657
101MP0010234_abnormal_vibrissa_follicle0.99194817
102MP0009780_abnormal_chondrocyte_physiolo0.97557014
103MP0009333_abnormal_splenocyte_physiolog0.96844139
104MP0000015_abnormal_ear_pigmentation0.96804165
105MP0000955_abnormal_spinal_cord0.96233365
106MP0005551_abnormal_eye_electrophysiolog0.96208593
107MP0002882_abnormal_neuron_morphology0.95526076
108MP0009763_increased_sensitivity_to0.92619232
109MP0002876_abnormal_thyroid_physiology0.92178061
110MP0006276_abnormal_autonomic_nervous0.90838469
111MP0005025_abnormal_response_to0.90317211
112MP0002557_abnormal_social/conspecific_i0.89006810
113MP0003763_abnormal_thymus_physiology0.88751317
114MP0000858_altered_metastatic_potential0.87994149
115MP0003279_aneurysm0.87539464
116MP0004484_altered_response_of0.87025109
117MP0000716_abnormal_immune_system0.86817244
118MP0001177_atelectasis0.86252383
119MP0003186_abnormal_redox_activity0.85770299
120MP0002877_abnormal_melanocyte_morpholog0.85173582
121MP0000249_abnormal_blood_vessel0.84757727
122MP0005584_abnormal_enzyme/coenzyme_acti0.83452928
123MP0002295_abnormal_pulmonary_circulatio0.83082342
124MP0005535_abnormal_body_temperature0.82736562
125MP0008874_decreased_physiological_sensi0.82607185
126MP0008004_abnormal_stomach_pH0.82552952
127MP0001963_abnormal_hearing_physiology0.81540022
128MP0003879_abnormal_hair_cell0.81396222
129MP0001756_abnormal_urination0.81077803
130MP0001790_abnormal_immune_system0.80808993
131MP0005387_immune_system_phenotype0.80808993
132MP0001986_abnormal_taste_sensitivity0.80120274
133MP0002909_abnormal_adrenal_gland0.79619635
134MP0003091_abnormal_cell_migration0.79024475
135MP0001533_abnormal_skeleton_physiology0.78803757
136MP0002723_abnormal_immune_serum0.77990574
137MP0001851_eye_inflammation0.76889264
138MP0000013_abnormal_adipose_tissue0.76681188
139MP0004811_abnormal_neuron_physiology0.75688638
140MP0003795_abnormal_bone_structure0.75529197
141MP0005165_increased_susceptibility_to0.74368522
142MP0001664_abnormal_digestion0.73435355
143MP0001765_abnormal_ion_homeostasis0.73304132
144MP0005166_decreased_susceptibility_to0.72933711
145MP0002184_abnormal_innervation0.72305814
146MP0009840_abnormal_foam_cell0.72004579
147MP0005167_abnormal_blood-brain_barrier0.71887231
148MP0002420_abnormal_adaptive_immunity0.71852767
149MP0001819_abnormal_immune_cell0.70133933
150MP0005595_abnormal_vascular_smooth0.68198606
151MP0005390_skeleton_phenotype0.67518595
152MP0003453_abnormal_keratinocyte_physiol0.64359112
153MP0002118_abnormal_lipid_homeostasis0.63500032
154MP0009643_abnormal_urine_homeostasis0.62258343
155MP0005636_abnormal_mineral_homeostasis0.62099881
156MP0003045_fibrosis0.61736442
157MP0005085_abnormal_gallbladder_physiolo0.61307095

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.35879798
2Supranuclear gaze palsy (HP:0000605)4.01690558
3Focal motor seizures (HP:0011153)3.93202049
4Cerebral inclusion bodies (HP:0100314)3.84982980
5Myokymia (HP:0002411)3.57994550
6Parakeratosis (HP:0001036)3.42276722
7Eczematoid dermatitis (HP:0000976)3.25998879
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.18672419
9Degeneration of the lateral corticospinal tracts (HP:0002314)3.18672419
10Systemic lupus erythematosus (HP:0002725)3.15831083
11Retinal dysplasia (HP:0007973)3.12400920
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.10038513
13Petechiae (HP:0000967)2.94248859
14Ankle clonus (HP:0011448)2.92059100
15Abnormality of polysaccharide metabolism (HP:0011012)2.91350521
16Abnormality of glycosaminoglycan metabolism (HP:0004371)2.91350521
17Abnormality of mucopolysaccharide metabolism (HP:0011020)2.91350521
18Pheochromocytoma (HP:0002666)2.84917842
19Urinary glycosaminoglycan excretion (HP:0003541)2.81834135
20Mucopolysacchariduria (HP:0008155)2.81834135
21Epileptic encephalopathy (HP:0200134)2.75394663
22Neuroendocrine neoplasm (HP:0100634)2.75285612
23Peripheral hypomyelination (HP:0007182)2.73984552
24Abnormality of glycolipid metabolism (HP:0010969)2.71065325
25Abnormality of liposaccharide metabolism (HP:0010968)2.71065325
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.71065325
27Purpura (HP:0000979)2.68444185
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.68375178
29Increased circulating renin level (HP:0000848)2.66176254
30Abnormality of macrophages (HP:0004311)2.64754245
31Hypokalemic alkalosis (HP:0001949)2.63542811
32Vacuolated lymphocytes (HP:0001922)2.62568045
33Intention tremor (HP:0002080)2.59116004
34Acute necrotizing encephalopathy (HP:0006965)2.58232823
35Dysmetria (HP:0001310)2.57806361
36Elevated erythrocyte sedimentation rate (HP:0003565)2.57754815
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.52977420
38Dysostosis multiplex (HP:0000943)2.52475882
39Myositis (HP:0100614)2.52165158
40Atonic seizures (HP:0010819)2.49479480
41Cerebral hemorrhage (HP:0001342)2.46513076
42Increased cerebral lipofuscin (HP:0011813)2.43661386
43Orchitis (HP:0100796)2.42570302
44Mitochondrial inheritance (HP:0001427)2.41369431
45Metabolic alkalosis (HP:0200114)2.40282914
46Focal seizures (HP:0007359)2.38008911
47Progressive neurologic deterioration (HP:0002344)2.37283624
48Visual hallucinations (HP:0002367)2.36603917
49Progressive inability to walk (HP:0002505)2.35194817
50Renal Fanconi syndrome (HP:0001994)2.35183325
51Abnormal mitochondria in muscle tissue (HP:0008316)2.33120714
52Slow saccadic eye movements (HP:0000514)2.32685779
53Abnormality of the corticospinal tract (HP:0002492)2.32332406
54Action tremor (HP:0002345)2.32187887
55Anxiety (HP:0000739)2.30524616
56Clumsiness (HP:0002312)2.29789007
57Absence seizures (HP:0002121)2.29118288
58Optic neuritis (HP:0100653)2.26017602
59Retrobulbar optic neuritis (HP:0100654)2.26017602
60Loss of speech (HP:0002371)2.25528949
61Abnormality of magnesium homeostasis (HP:0004921)2.24031545
62Spastic gait (HP:0002064)2.23993637
63Leukodystrophy (HP:0002415)2.23470281
64Megalencephaly (HP:0001355)2.21592679
65Split foot (HP:0001839)2.19193603
66Dialeptic seizures (HP:0011146)2.19056847
67Segmental peripheral demyelination/remyelination (HP:0003481)2.18461822
68Abnormality of binocular vision (HP:0011514)2.18110744
69Diplopia (HP:0000651)2.18110744
70Spontaneous hematomas (HP:0007420)2.16984272
71Hepatocellular necrosis (HP:0001404)2.15417539
72Amyloidosis (HP:0011034)2.13136685
73Progressive macrocephaly (HP:0004481)2.12737841
74Chronic diarrhea (HP:0002028)2.11766415
75Hypomagnesemia (HP:0002917)2.11547355
76Interstitial pulmonary disease (HP:0006530)2.10561764
77Cerebral hypomyelination (HP:0006808)2.09624119
78Hepatosplenomegaly (HP:0001433)2.08353612
79Generalized tonic-clonic seizures (HP:0002069)2.08120251
80Akinesia (HP:0002304)2.07028614
81Stomatitis (HP:0010280)2.06665170
82Mutism (HP:0002300)2.05987387
83Scanning speech (HP:0002168)2.05958866
84Recurrent abscess formation (HP:0002722)2.05446291
85Onion bulb formation (HP:0003383)2.05430974
86Asymmetric septal hypertrophy (HP:0001670)2.04699201
87Acute encephalopathy (HP:0006846)2.03792779
88Increased CSF protein (HP:0002922)2.01991918
89Gingival bleeding (HP:0000225)2.01815132
90Hyperaldosteronism (HP:0000859)2.01680373
91Disinhibition (HP:0000734)2.01169837
92Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00090634
93Metaphyseal dysplasia (HP:0100255)1.99493411
94Sensorimotor neuropathy (HP:0007141)1.98958204
95Chronic otitis media (HP:0000389)1.98548356
96Delusions (HP:0000746)1.97310823
97Increased hepatocellular lipid droplets (HP:0006565)1.96552560
98Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94459520
99Type II lissencephaly (HP:0007260)1.94044524
100Mitral stenosis (HP:0001718)1.93032443
101Psychosis (HP:0000709)1.92161307
102Generalized myoclonic seizures (HP:0002123)1.91234628
103Hypothermia (HP:0002045)1.91140453
104Axonal loss (HP:0003447)1.90430771
105Recurrent skin infections (HP:0001581)1.89477965
106Increased serum pyruvate (HP:0003542)1.89174162
107Abnormality of glycolysis (HP:0004366)1.89174162
108Abnormal eating behavior (HP:0100738)1.88713854
109Premature loss of primary teeth (HP:0006323)1.88501610
110Neuronal loss in central nervous system (HP:0002529)1.86690465
111T lymphocytopenia (HP:0005403)1.86334664
112Hyperactive renin-angiotensin system (HP:0000841)1.85632438
113Progressive cerebellar ataxia (HP:0002073)1.85364146
114Pulmonary infiltrates (HP:0002113)1.84567721
115Arterial tortuosity (HP:0005116)1.84175830
116Congenital ichthyosiform erythroderma (HP:0007431)1.84147479
117Abnormality of renal resorption (HP:0011038)1.83135849
118Sensory axonal neuropathy (HP:0003390)1.82748241
119Recurrent bacterial skin infections (HP:0005406)1.82654380
120Epistaxis (HP:0000421)1.81990606
121Spastic paraparesis (HP:0002313)1.80244509
122Increased CSF lactate (HP:0002490)1.79179764
123Nuclear cataract (HP:0100018)1.78777412
124Rigidity (HP:0002063)1.77821956
125Prolonged neonatal jaundice (HP:0006579)1.77402683
126Basal ganglia calcification (HP:0002135)1.77084914
127Prolonged bleeding time (HP:0003010)1.77027311
128Urticaria (HP:0001025)1.76926588
129Insidious onset (HP:0003587)1.76460047
130Termporal pattern (HP:0011008)1.76460047
131Growth hormone excess (HP:0000845)1.76289175
132Polyneuropathy (HP:0001271)1.76220108
133Polyphagia (HP:0002591)1.75076082
134Poor speech (HP:0002465)1.74857226
135Tetraparesis (HP:0002273)1.74491486
136Abnormality of renin-angiotensin system (HP:0000847)1.74378039
137Depression (HP:0000716)1.73715583
138Hematochezia (HP:0002573)1.73502067
139Vertebral compression fractures (HP:0002953)1.71712257
140Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71305956
141Diminished motivation (HP:0000745)1.70973144
142Episodic fever (HP:0001954)1.70173807
143Glomerulonephritis (HP:0000099)1.69651810
144Amyotrophic lateral sclerosis (HP:0007354)1.67559846
145Apathy (HP:0000741)1.67559320
146Hyperlipoproteinemia (HP:0010980)1.66076070
147Conjunctival telangiectasia (HP:0000524)1.65953408
148Joint swelling (HP:0001386)1.65406303
149Hypergammaglobulinemia (HP:0010702)1.63561804
150Malnutrition (HP:0004395)1.62963119
151Abnormality of T cell number (HP:0011839)1.62658663
152Bone cyst (HP:0012062)1.62294958
153Steatorrhea (HP:0002570)1.61810078
154Recurrent gram-negative bacterial infections (HP:0005420)1.61404866
155Dementia (HP:0000726)1.58786224
156Global brain atrophy (HP:0002283)1.57652644
157Mediastinal lymphadenopathy (HP:0100721)1.56276652
158Abnormality of the costochondral junction (HP:0000919)1.55957125
159Encephalitis (HP:0002383)1.55229455
160Abnormality of the motor neurons (HP:0002450)1.54570712
161Abnormal neuron morphology (HP:0012757)1.54570712
162Facial diplegia (HP:0001349)1.52696571
163Fat malabsorption (HP:0002630)1.51557606
164Abnormality of the periventricular white matter (HP:0002518)1.51407063
165Chronic obstructive pulmonary disease (HP:0006510)1.51037417
166Obstructive lung disease (HP:0006536)1.51037417
167Keratoconjunctivitis sicca (HP:0001097)1.50956133
168Pulmonary embolism (HP:0002204)1.49241680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.67470331
2TESK13.38467767
3OXSR12.96085638
4EPHA42.46084599
5RIPK42.36188624
6ARAF2.35968169
7PRPF4B2.23227241
8TNIK2.17608780
9CDK192.17079822
10MAP3K122.15770398
11EPHB11.98546642
12NTRK31.86955429
13MAP3K131.83336987
14NTRK11.80656065
15TYK21.76736082
16MST41.73441319
17TAOK31.73408868
18MAPKAPK51.72069308
19CSK1.64145743
20MAP3K31.64120165
21WNK41.63833552
22BCR1.61797574
23ERBB31.59615822
24TESK21.57056233
25FES1.55022723
26PIM21.50796910
27MAP3K91.47577086
28LMTK21.45944375
29PBK1.44890883
30MAPKAPK31.43581018
31PKN11.42898028
32LIMK11.40208151
33BLK1.39686463
34JAK11.39521791
35MYLK1.38105575
36MAP3K111.32342532
37TAOK11.29319435
38TGFBR21.28757132
39EPHA31.25330238
40TXK1.25248755
41ERN11.24639468
42MAP2K71.22303896
43CSF1R1.21852464
44CAMK2B1.21755566
45GRK61.20821585
46MINK11.19980893
47CASK1.19743295
48GRK71.19363932
49KSR21.19226067
50BMPR21.17548880
51SIK31.15835305
52MUSK1.15699807
53MAP3K51.08255008
54CAMKK21.07050975
55CDK51.05339882
56TIE11.03633987
57MAP3K21.01957749
58SGK2231.01376326
59SGK4941.01376326
60CAMK2D1.00741346
61FGR0.99611327
62TAOK20.97641886
63GRK50.97094851
64ROCK20.93465945
65IRAK30.92724556
66FER0.92513601
67ABL20.92211948
68NEK60.91731883
69MAP3K60.89892830
70CAMK2G0.89183158
71TRPM70.89145101
72PINK10.87899477
73MARK10.87244933
74CAMK2A0.87032356
75IKBKB0.85788041
76TBK10.85287234
77NME10.83148211
78PAK60.82531910
79NEK90.81800264
80IRAK40.81200718
81MAPK120.80858196
82UHMK10.79900663
83MAPK70.79558868
84PRKCQ0.79190885
85MAP3K10.78393312
86IKBKE0.78207643
87LYN0.78123777
88HCK0.77739656
89MAP4K10.76343512
90WNK10.76107787
91PDK20.76045102
92CDK140.76023927
93PHKG20.74699043
94PHKG10.74699043
95MOS0.74474448
96ADRBK20.74469401
97MAP3K140.74376769
98STK160.74291828
99MAPK130.73934609
100CSNK1G20.73648413
101PRKCE0.72820284
102CSNK1G30.71748547
103PDPK10.71262601
104NTRK20.69871173
105DAPK20.69835851
106JAK20.68347561
107BMPR1B0.67912680
108ACVR1B0.66140753
109BTK0.65362283
110KIT0.64232443
111KDR0.63073050
112PDK10.61853427
113PTK2B0.61438121
114CDK180.61052753
115FYN0.60586996
116IRAK20.60424945
117ITK0.59700684
118STK240.59538721
119IRAK10.59383404
120CDK150.59361560
121SCYL20.58792427
122TEC0.57945435
123PRKG20.57907260
124SYK0.56394107
125RIPK10.55961571
126PAK30.55826981
127PLK20.55715688
128MAP2K30.55613033
129CLK10.54171358
130CAMKK10.52820652
131MARK20.52188145
132TYRO30.52187941
133CDK11A0.51868539
134PIK3CG0.50706467
135CAMK10.49056434
136CSNK1A1L0.48971425
137FGFR20.48329469
138PIK3CA0.47653517
139PRKCH0.47164615
140PRKD30.45989201
141LCK0.45804551
142ABL10.44950984
143MAP3K40.44215106
144ZAP700.43987164
145TNK20.43763829
146MATK0.43690315
147PRKD10.42800553
148MAP2K40.42714627
149JAK30.41327667
150TRIM280.39856565
151EIF2AK10.38961938
152IGF1R0.38586203

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.83904428
2Oxidative phosphorylation_Homo sapiens_hsa001902.37436854
3Synaptic vesicle cycle_Homo sapiens_hsa047212.26037776
4Collecting duct acid secretion_Homo sapiens_hsa049662.25958030
5Fatty acid elongation_Homo sapiens_hsa000622.23832982
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.15727589
7SNARE interactions in vesicular transport_Homo sapiens_hsa041301.98907252
8Steroid biosynthesis_Homo sapiens_hsa001001.96634066
9Vibrio cholerae infection_Homo sapiens_hsa051101.96186563
10Protein export_Homo sapiens_hsa030601.81577738
11Osteoclast differentiation_Homo sapiens_hsa043801.73184506
12Staphylococcus aureus infection_Homo sapiens_hsa051501.72736925
13GABAergic synapse_Homo sapiens_hsa047271.72615674
14Sphingolipid metabolism_Homo sapiens_hsa006001.68781558
15Parkinsons disease_Homo sapiens_hsa050121.67775517
16Alzheimers disease_Homo sapiens_hsa050101.67567982
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66257334
18Rheumatoid arthritis_Homo sapiens_hsa053231.65975673
19Ether lipid metabolism_Homo sapiens_hsa005651.65279075
20Lysosome_Homo sapiens_hsa041421.62453506
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60618173
22Sulfur metabolism_Homo sapiens_hsa009201.59544379
23Morphine addiction_Homo sapiens_hsa050321.55854227
24Nicotine addiction_Homo sapiens_hsa050331.55050165
25Glutamatergic synapse_Homo sapiens_hsa047241.54683592
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54506916
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42721982
28Circadian entrainment_Homo sapiens_hsa047131.42643501
29Serotonergic synapse_Homo sapiens_hsa047261.41803953
30Antigen processing and presentation_Homo sapiens_hsa046121.38707889
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38278403
32Hematopoietic cell lineage_Homo sapiens_hsa046401.35917416
33Salivary secretion_Homo sapiens_hsa049701.35750255
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34952365
35Gastric acid secretion_Homo sapiens_hsa049711.32055297
36Olfactory transduction_Homo sapiens_hsa047401.31422804
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28306312
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25293906
39Asthma_Homo sapiens_hsa053101.24198268
40Other glycan degradation_Homo sapiens_hsa005111.20748950
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20536673
42Long-term potentiation_Homo sapiens_hsa047201.20105514
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.20045241
44Phagosome_Homo sapiens_hsa041451.18671745
45Legionellosis_Homo sapiens_hsa051341.12831973
46Viral myocarditis_Homo sapiens_hsa054161.10829585
47Dopaminergic synapse_Homo sapiens_hsa047281.10319090
48Cholinergic synapse_Homo sapiens_hsa047251.09058294
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08366382
50Sphingolipid signaling pathway_Homo sapiens_hsa040711.07457245
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07353971
52Mineral absorption_Homo sapiens_hsa049781.05775613
53Long-term depression_Homo sapiens_hsa047301.03182452
54Toxoplasmosis_Homo sapiens_hsa051450.95137801
55Cardiac muscle contraction_Homo sapiens_hsa042600.94730042
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94259898
57Insulin secretion_Homo sapiens_hsa049110.93851363
58Renin secretion_Homo sapiens_hsa049240.93691322
59Pancreatic secretion_Homo sapiens_hsa049720.92804596
60Taste transduction_Homo sapiens_hsa047420.92349158
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.92149944
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91483002
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91316652
64Amphetamine addiction_Homo sapiens_hsa050310.90432710
65Graft-versus-host disease_Homo sapiens_hsa053320.90358642
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89808171
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89682097
68Salmonella infection_Homo sapiens_hsa051320.88047923
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87811216
70TNF signaling pathway_Homo sapiens_hsa046680.87063497
71Endocytosis_Homo sapiens_hsa041440.86969351
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85988807
73Cocaine addiction_Homo sapiens_hsa050300.84177123
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82315254
75PPAR signaling pathway_Homo sapiens_hsa033200.81230871
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80114741
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79174741
78Huntingtons disease_Homo sapiens_hsa050160.76086526
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75530250
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75497530
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75193379
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74800336
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72954097
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72443083
85Axon guidance_Homo sapiens_hsa043600.72233493
86Calcium signaling pathway_Homo sapiens_hsa040200.72084738
87Primary immunodeficiency_Homo sapiens_hsa053400.71418255
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.71410588
89Tuberculosis_Homo sapiens_hsa051520.69470804
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.68702877
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67832363
92Regulation of autophagy_Homo sapiens_hsa041400.66295616
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.65265087
94Type I diabetes mellitus_Homo sapiens_hsa049400.65115766
95African trypanosomiasis_Homo sapiens_hsa051430.64956702
96Platelet activation_Homo sapiens_hsa046110.64437701
97Peroxisome_Homo sapiens_hsa041460.64336869
98Allograft rejection_Homo sapiens_hsa053300.64222777
99Oxytocin signaling pathway_Homo sapiens_hsa049210.63843555
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.63577915
101Chemokine signaling pathway_Homo sapiens_hsa040620.62497021
102Malaria_Homo sapiens_hsa051440.61977905
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60999082
104Hepatitis C_Homo sapiens_hsa051600.60885337
105Pertussis_Homo sapiens_hsa051330.60307158
106cAMP signaling pathway_Homo sapiens_hsa040240.60226490
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60134636
108Phototransduction_Homo sapiens_hsa047440.59430363
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56847594
110Renin-angiotensin system_Homo sapiens_hsa046140.56707310
111Shigellosis_Homo sapiens_hsa051310.56508374
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56003500
113Autoimmune thyroid disease_Homo sapiens_hsa053200.55065186
114Amoebiasis_Homo sapiens_hsa051460.54375451
115Nitrogen metabolism_Homo sapiens_hsa009100.54359521
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54153156
117Ras signaling pathway_Homo sapiens_hsa040140.53575528
118Influenza A_Homo sapiens_hsa051640.53291904
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52291856
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.51987278
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50974999
122Galactose metabolism_Homo sapiens_hsa000520.50017236
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.48572541
124Leishmaniasis_Homo sapiens_hsa051400.47104831
125Measles_Homo sapiens_hsa051620.47030853
126Gap junction_Homo sapiens_hsa045400.46875023
127Histidine metabolism_Homo sapiens_hsa003400.46408412
128GnRH signaling pathway_Homo sapiens_hsa049120.45936465
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45004028
130Phenylalanine metabolism_Homo sapiens_hsa003600.44240588
131Prion diseases_Homo sapiens_hsa050200.44074317
132Renal cell carcinoma_Homo sapiens_hsa052110.42369910
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41910589
134Circadian rhythm_Homo sapiens_hsa047100.40406971
135B cell receptor signaling pathway_Homo sapiens_hsa046620.40251187
136T cell receptor signaling pathway_Homo sapiens_hsa046600.39781226
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39033349
138Choline metabolism in cancer_Homo sapiens_hsa052310.38240612
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38238560
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37107404
141Glutathione metabolism_Homo sapiens_hsa004800.36288126
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33409313
143beta-Alanine metabolism_Homo sapiens_hsa004100.31729313
144Fatty acid metabolism_Homo sapiens_hsa012120.30943661
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.30539851
146Arachidonic acid metabolism_Homo sapiens_hsa005900.30519758
147Herpes simplex infection_Homo sapiens_hsa051680.29569460

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