TMIE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.27456165
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.27456165
3L-phenylalanine metabolic process (GO:0006558)6.95924616
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.95924616
5aromatic amino acid family catabolic process (GO:0009074)6.37933913
6regulation of synaptic vesicle exocytosis (GO:2000300)5.91810469
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.87948701
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.62150415
9glutamate secretion (GO:0014047)5.61483789
10indole-containing compound catabolic process (GO:0042436)5.60584636
11indolalkylamine catabolic process (GO:0046218)5.60584636
12tryptophan catabolic process (GO:0006569)5.60584636
13synaptic vesicle exocytosis (GO:0016079)5.60344190
14synaptic vesicle maturation (GO:0016188)5.60075815
15bile acid biosynthetic process (GO:0006699)5.54760942
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.47663361
17sodium ion export (GO:0071436)5.41029390
18kynurenine metabolic process (GO:0070189)5.39330386
19cellular potassium ion homeostasis (GO:0030007)5.29530614
20tryptophan metabolic process (GO:0006568)5.15518643
21cysteine metabolic process (GO:0006534)5.15034471
22glyoxylate metabolic process (GO:0046487)5.11703626
23regulation of synaptic vesicle transport (GO:1902803)5.11098268
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.03627072
25postsynaptic membrane organization (GO:0001941)5.03357884
26high-density lipoprotein particle remodeling (GO:0034375)4.98506521
27alpha-linolenic acid metabolic process (GO:0036109)4.91074839
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.85426998
29urea cycle (GO:0000050)4.85084414
30urea metabolic process (GO:0019627)4.85084414
31negative regulation of inclusion body assembly (GO:0090084)4.83457195
32aromatic amino acid family metabolic process (GO:0009072)4.81889883
33sulfur amino acid catabolic process (GO:0000098)4.74805808
34negative regulation of fibrinolysis (GO:0051918)4.71088969
35vocalization behavior (GO:0071625)4.70985015
36tyrosine metabolic process (GO:0006570)4.67646777
37regulation of fibrinolysis (GO:0051917)4.63509133
38locomotory exploration behavior (GO:0035641)4.62977649
39coenzyme catabolic process (GO:0009109)4.61306028
40bile acid metabolic process (GO:0008206)4.59435547
41protein carboxylation (GO:0018214)4.58880814
42peptidyl-glutamic acid carboxylation (GO:0017187)4.58880814
43indolalkylamine metabolic process (GO:0006586)4.58709538
44regulation of short-term neuronal synaptic plasticity (GO:0048172)4.56727754
45nitrogen cycle metabolic process (GO:0071941)4.55898129
46alkaloid metabolic process (GO:0009820)4.52645104
47complement activation, alternative pathway (GO:0006957)4.50502155
48serine family amino acid catabolic process (GO:0009071)4.49003551
49imidazole-containing compound metabolic process (GO:0052803)4.48200497
50positive regulation of potassium ion transmembrane transport (GO:1901381)4.45215343
51positive regulation of dendritic spine development (GO:0060999)4.44478191
52regulation of protein activation cascade (GO:2000257)4.44292304
53neurotransmitter-gated ion channel clustering (GO:0072578)4.43816364
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.43143030
55regulation of cholesterol esterification (GO:0010872)4.43086353
56neuron cell-cell adhesion (GO:0007158)4.39432509
57cellular ketone body metabolic process (GO:0046950)4.33545507
58alpha-amino acid catabolic process (GO:1901606)4.30695274
59reverse cholesterol transport (GO:0043691)4.30571811
60glutamate metabolic process (GO:0006536)4.30135763
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.22041398
62protein-lipid complex remodeling (GO:0034368)4.19443453
63macromolecular complex remodeling (GO:0034367)4.19443453
64plasma lipoprotein particle remodeling (GO:0034369)4.19443453
65regulation of synapse structural plasticity (GO:0051823)4.18980029
66ionotropic glutamate receptor signaling pathway (GO:0035235)4.18651130
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17616930
68regulation of triglyceride catabolic process (GO:0010896)4.16906422
69triglyceride homeostasis (GO:0070328)4.15534574
70acylglycerol homeostasis (GO:0055090)4.15534574
71neuronal action potential propagation (GO:0019227)4.13546076
72neurotransmitter secretion (GO:0007269)4.12333301
73regulation of complement activation (GO:0030449)4.11949728
74amino-acid betaine metabolic process (GO:0006577)4.11870009
75amine catabolic process (GO:0009310)4.11247902
76cellular biogenic amine catabolic process (GO:0042402)4.11247902
77protein localization to synapse (GO:0035418)4.10946923
78phospholipid efflux (GO:0033700)4.07079854
79lysine metabolic process (GO:0006553)4.04222469
80lysine catabolic process (GO:0006554)4.04222469
81cellular amino acid catabolic process (GO:0009063)4.04159295
82negative regulation of sterol transport (GO:0032372)4.01218579
83negative regulation of cholesterol transport (GO:0032375)4.01218579
84bile acid and bile salt transport (GO:0015721)4.00057493
85regulation of inclusion body assembly (GO:0090083)3.99818559
86ethanol oxidation (GO:0006069)3.99252143
87cerebellar granule cell differentiation (GO:0021707)3.95495543
88regulation of neuronal synaptic plasticity (GO:0048168)3.93794919
89homocysteine metabolic process (GO:0050667)3.90468483
90benzene-containing compound metabolic process (GO:0042537)3.90340144
91positive regulation of synapse maturation (GO:0090129)3.89680753
92presynaptic membrane assembly (GO:0097105)3.85241835
93aldehyde catabolic process (GO:0046185)3.83967253
94cellular modified amino acid catabolic process (GO:0042219)3.83714558
95L-amino acid import (GO:0043092)3.82135861
96positive regulation of potassium ion transport (GO:0043268)3.80146116
97dicarboxylic acid biosynthetic process (GO:0043650)3.77456710
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.77124592
99arginine metabolic process (GO:0006525)3.76804625
100exploration behavior (GO:0035640)3.76617199
101short-chain fatty acid metabolic process (GO:0046459)3.75512636
102positive regulation of membrane potential (GO:0045838)3.75399876
103positive regulation of neurotransmitter secretion (GO:0001956)3.74749635
104ketone body metabolic process (GO:1902224)3.74015021
105cellular glucuronidation (GO:0052695)3.71719851
106presynaptic membrane organization (GO:0097090)3.69701893
107cholesterol efflux (GO:0033344)3.68396209
108potassium ion import (GO:0010107)3.66598609
109cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.66212932
110low-density lipoprotein particle remodeling (GO:0034374)3.65033429
111plasma lipoprotein particle clearance (GO:0034381)3.62564070
112acidic amino acid transport (GO:0015800)3.59566969
113cofactor catabolic process (GO:0051187)3.59411689
114opsonization (GO:0008228)3.58936015
115positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.58462102
116synaptic vesicle endocytosis (GO:0048488)3.58074082
117synaptic transmission, glutamatergic (GO:0035249)3.57519528
118organic acid catabolic process (GO:0016054)3.57298201
119carboxylic acid catabolic process (GO:0046395)3.57298201
120regulation of excitatory postsynaptic membrane potential (GO:0060079)3.57068964
121regulation of neurotransmitter secretion (GO:0046928)3.56931673
122potassium ion homeostasis (GO:0055075)3.55873206
123dendritic spine morphogenesis (GO:0060997)3.55434755
124glucuronate metabolic process (GO:0019585)3.55248818
125uronic acid metabolic process (GO:0006063)3.55248818
126regulation of long-term neuronal synaptic plasticity (GO:0048169)3.51397449
127cellular sodium ion homeostasis (GO:0006883)3.50505560
128serine family amino acid metabolic process (GO:0009069)3.50347120
129regulation of glutamate receptor signaling pathway (GO:1900449)3.50207311
130neurotransmitter transport (GO:0006836)3.49160912
131regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47052316
132neurotransmitter uptake (GO:0001504)3.47029590
133drug catabolic process (GO:0042737)3.45792334
134L-glutamate transport (GO:0015813)3.45087974
135neuromuscular process controlling balance (GO:0050885)3.42800323
136neuromuscular synaptic transmission (GO:0007274)3.42189044
137glycine metabolic process (GO:0006544)3.41628909
138blood coagulation, intrinsic pathway (GO:0007597)3.40791267
139long-term memory (GO:0007616)3.40576113
140negative regulation of lipase activity (GO:0060192)3.40287476
141monocarboxylic acid catabolic process (GO:0072329)3.35993624
142calcium ion-dependent exocytosis (GO:0017156)3.35094033
143gamma-aminobutyric acid transport (GO:0015812)3.34834002
144fibrinolysis (GO:0042730)3.34430849
145glutamate receptor signaling pathway (GO:0007215)3.34368507
146plasma lipoprotein particle assembly (GO:0034377)3.34216620
147amino acid import (GO:0043090)3.33349977
148NAD biosynthetic process (GO:0009435)3.33150240
149drug transmembrane transport (GO:0006855)3.32978275
150gamma-aminobutyric acid signaling pathway (GO:0007214)3.32161189
151positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.30520429
152positive regulation of neurotransmitter transport (GO:0051590)3.28696754
153acetyl-CoA metabolic process (GO:0006084)3.28194161
154very long-chain fatty acid metabolic process (GO:0000038)3.26882899
155indole-containing compound metabolic process (GO:0042430)3.25377251
156regulation of vesicle fusion (GO:0031338)3.25120661
157positive regulation of lipoprotein lipase activity (GO:0051006)3.24225935
158positive regulation of triglyceride lipase activity (GO:0061365)3.24225935
159auditory behavior (GO:0031223)3.24167889
160layer formation in cerebral cortex (GO:0021819)3.24062890
161regulation of neurotransmitter transport (GO:0051588)3.23504451
162transmission of nerve impulse (GO:0019226)3.23030125
163potassium ion export (GO:0071435)3.21603801
164regulation of neurotransmitter levels (GO:0001505)3.21409440
165response to nitrosative stress (GO:0051409)3.21332961
166pyridine nucleotide biosynthetic process (GO:0019363)3.21258717
167nicotinamide nucleotide biosynthetic process (GO:0019359)3.21258717
168regulation of postsynaptic membrane potential (GO:0060078)3.21066832
169regulation of dendritic spine development (GO:0060998)3.20334909
170complement activation, classical pathway (GO:0006958)3.20025200
171regulation of plasminogen activation (GO:0010755)3.18835268
172regulation of synaptic plasticity (GO:0048167)3.18691129
173flavonoid metabolic process (GO:0009812)3.18385936
174response to auditory stimulus (GO:0010996)3.18007880
175protein activation cascade (GO:0072376)3.17880330
176central nervous system myelination (GO:0022010)3.17755765
177axon ensheathment in central nervous system (GO:0032291)3.17755765
178cytolysis (GO:0019835)3.16858156
179regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16696765
180regulation of voltage-gated calcium channel activity (GO:1901385)3.16339722
181dendritic spine organization (GO:0097061)3.14859410
182membrane repolarization (GO:0086009)3.14247324
183regulation of bile acid biosynthetic process (GO:0070857)3.14195942
184cell communication by electrical coupling (GO:0010644)3.12016576
185positive regulation of dendritic spine morphogenesis (GO:0061003)3.08544172
186acrosome reaction (GO:0007340)3.07972396
187spermatid nucleus differentiation (GO:0007289)3.05319466
188regulation of ARF protein signal transduction (GO:0032012)3.04880661
189regulation of dendritic spine morphogenesis (GO:0061001)3.04347051
190neuron-neuron synaptic transmission (GO:0007270)3.02566429
191neuronal ion channel clustering (GO:0045161)3.02354565
192cerebral cortex neuron differentiation (GO:0021895)2.97078775
193regulation of synaptic transmission, glutamatergic (GO:0051966)2.96554123
194regulation of membrane repolarization (GO:0060306)2.95364583
195membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.94918124
196cytoskeletal anchoring at plasma membrane (GO:0007016)2.94113516
197membrane depolarization during action potential (GO:0086010)2.93074962
198positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.92548711
199mating behavior (GO:0007617)2.90843095
200membrane depolarization (GO:0051899)2.89125643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.32373270
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.47961332
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.53374370
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.35226891
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.99963600
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.18822430
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.70513236
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.23532541
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.12752499
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.91565098
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.91339325
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.55393592
13RNF2_27304074_Chip-Seq_ESCs_Mouse2.46108576
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37088275
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22936896
16TAF15_26573619_Chip-Seq_HEK293_Human2.10334517
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06293676
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86063143
19RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.82450088
20RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.71060061
21HTT_18923047_ChIP-ChIP_STHdh_Human1.70235481
22LXR_22292898_ChIP-Seq_THP-1_Human1.64111528
23* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60219419
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59024189
25* KDM2B_26808549_Chip-Seq_K562_Human1.52958360
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49122174
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46908354
28RING1B_27294783_Chip-Seq_ESCs_Mouse1.45125013
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44186334
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43979419
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40510263
32SMC4_20622854_ChIP-Seq_HELA_Human1.40047833
33EZH2_22144423_ChIP-Seq_EOC_Human1.38813954
34GBX2_23144817_ChIP-Seq_PC3_Human1.31418166
35* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30756541
36* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30264348
37* TET1_21490601_ChIP-Seq_MESCs_Mouse1.29873573
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28952867
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26661513
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.25404223
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23477230
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.19617526
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.19328515
44P68_20966046_ChIP-Seq_HELA_Human1.18201139
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16451942
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15828890
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15433957
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15290900
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14068037
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13962015
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10774709
52GATA1_22025678_ChIP-Seq_K562_Human1.09860572
53RNF2_27304074_Chip-Seq_NSC_Mouse1.09766417
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.09563426
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09272115
56OCT4_19829295_ChIP-Seq_ESCs_Human1.08028207
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06114437
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05313257
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04893126
60REST_21632747_ChIP-Seq_MESCs_Mouse1.02839730
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.01283074
62SA1_27219007_Chip-Seq_Bcells_Human1.00553383
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00216117
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00074208
65KLF4_19829295_ChIP-Seq_ESCs_Human0.99528352
66CTCF_20526341_ChIP-Seq_ESCs_Human0.99059547
67AR_21572438_ChIP-Seq_LNCaP_Human0.98451440
68PIAS1_25552417_ChIP-Seq_VCAP_Human0.98284171
69P300_19829295_ChIP-Seq_ESCs_Human0.98164932
70* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97815612
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97762008
72JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96817964
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96577911
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96209980
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96141566
76KDM2B_26808549_Chip-Seq_DND41_Human0.96114846
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96001398
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95596328
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94827622
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94215902
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93478028
82JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93089146
83BCAT_22108803_ChIP-Seq_LS180_Human0.93041039
84HNF4A_19822575_ChIP-Seq_HepG2_Human0.92814307
85WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92809263
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92438209
87LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91881493
88ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91662540
89* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91308344
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90818206
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89937939
92* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89642664
93ERG_21242973_ChIP-ChIP_JURKAT_Human0.89456961
94DPY_21335234_ChIP-Seq_ESCs_Mouse0.89447621
95IGF1R_20145208_ChIP-Seq_DFB_Human0.88032181
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87714785
97WDR5_24793694_ChIP-Seq_LNCAP_Human0.87608291
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87078306
99TP53_23651856_ChIP-Seq_MEFs_Mouse0.86985040
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86282151
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85035380
102SMAD4_21741376_ChIP-Seq_ESCs_Human0.84010519
103RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83920078
104EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83920078
105AR_19668381_ChIP-Seq_PC3_Human0.83754016
106RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82626447
107* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82612008
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82497757
109KDM2B_26808549_Chip-Seq_JURKAT_Human0.81914413
110* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81880839
111ELF1_20517297_ChIP-Seq_JURKAT_Human0.81821016
112* REST_18959480_ChIP-ChIP_MESCs_Mouse0.81552031
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81305405
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81305405
115EED_16625203_ChIP-ChIP_MESCs_Mouse0.81181723
116CLOCK_20551151_ChIP-Seq_293T_Human0.81038147
117EZH2_27294783_Chip-Seq_ESCs_Mouse0.80802603
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79774055
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79428631
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79428631
121* TP63_22573176_ChIP-Seq_HFKS_Human0.78810619
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78688514
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78299086
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.77605678
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77192393
126SOX2_21211035_ChIP-Seq_LN229_Gbm0.76719348
127SMAD4_21799915_ChIP-Seq_A2780_Human0.74889608
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.74407502
129DROSHA_22980978_ChIP-Seq_HELA_Human0.74015919
130ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73615007
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.73210586
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72437816
133ZNF274_21170338_ChIP-Seq_K562_Hela0.71935652
134CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71503610
135KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71047719
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.70930301
137AR_25329375_ChIP-Seq_VCAP_Human0.70851771
138IRF1_19129219_ChIP-ChIP_H3396_Human0.69731745
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.69590923
140SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.69418340
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.68621538
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.67088567
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.66795113
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.66621672
145EZH2_27294783_Chip-Seq_NPCs_Mouse0.66590773
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.66442922
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.65936208
148CBP_20019798_ChIP-Seq_JUKART_Human0.65936208
149BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65706343
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.65137939
151RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.63932830
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.62893168
153MYC_19915707_ChIP-ChIP_AK7_Human0.62439313
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.61287438
155AR_20517297_ChIP-Seq_VCAP_Human0.61277245
156BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.61173395
157NCOR_22424771_ChIP-Seq_293T_Human0.60935069
158SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.59853614
159IRF8_22096565_ChIP-ChIP_GC-B_Human0.59761222
160CTCF_27219007_Chip-Seq_Bcells_Human0.59484293
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.59121289
162POU3F2_20337985_ChIP-ChIP_501MEL_Human0.58702572
163EZH2_27304074_Chip-Seq_ESCs_Mouse0.58113898
164BMI1_23680149_ChIP-Seq_NPCS_Mouse0.57666674
165ESR2_21235772_ChIP-Seq_MCF-7_Human0.57289454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.98204589
2MP0005360_urolithiasis6.71706452
3MP0005085_abnormal_gallbladder_physiolo5.74362149
4MP0004859_abnormal_synaptic_plasticity5.73512283
5MP0005365_abnormal_bile_salt5.53689692
6MP0008875_abnormal_xenobiotic_pharmacok4.60497070
7MP0005377_hearing/vestibular/ear_phenot3.74913054
8MP0003878_abnormal_ear_physiology3.74913054
9MP0004270_analgesia3.34361895
10MP0003252_abnormal_bile_duct3.29173351
11MP0003806_abnormal_nucleotide_metabolis3.13134464
12MP0010329_abnormal_lipoprotein_level3.08811964
13MP0005083_abnormal_biliary_tract3.07920837
14* MP0001486_abnormal_startle_reflex2.98193788
15MP0002063_abnormal_learning/memory/cond2.85062752
16MP0005332_abnormal_amino_acid2.65852480
17MP0003195_calcinosis2.58591613
18MP0001666_abnormal_nutrient_absorption2.55064258
19MP0002734_abnormal_mechanical_nocicepti2.46685238
20MP0008569_lethality_at_weaning2.43852308
21MP0002735_abnormal_chemical_nociception2.42593523
22MP0009840_abnormal_foam_cell2.28937720
23MP0001970_abnormal_pain_threshold2.24973317
24MP0002138_abnormal_hepatobiliary_system2.21663569
25MP0005410_abnormal_fertilization2.21431302
26MP0005167_abnormal_blood-brain_barrier2.19547064
27MP0003868_abnormal_feces_composition2.16834605
28MP0001485_abnormal_pinna_reflex2.06553007
29MP0002118_abnormal_lipid_homeostasis1.91443688
30MP0006276_abnormal_autonomic_nervous1.87379536
31MP0002876_abnormal_thyroid_physiology1.85532807
32MP0004019_abnormal_vitamin_homeostasis1.76654206
33MP0000609_abnormal_liver_physiology1.76512529
34MP0010386_abnormal_urinary_bladder1.72430620
35MP0004885_abnormal_endolymph1.68009059
36MP0005584_abnormal_enzyme/coenzyme_acti1.61157133
37MP0002822_catalepsy1.57604400
38MP0003631_nervous_system_phenotype1.54662177
39MP0003191_abnormal_cellular_cholesterol1.53113445
40MP0000778_abnormal_nervous_system1.52291606
41MP0005319_abnormal_enzyme/_coenzyme1.51448688
42MP0001764_abnormal_homeostasis1.49475614
43* MP0002557_abnormal_social/conspecific_i1.46226298
44MP0002254_reproductive_system_inflammat1.43847630
45MP0009697_abnormal_copulation1.38534883
46MP0002653_abnormal_ependyma_morphology1.38266522
47MP0005535_abnormal_body_temperature1.37970993
48MP0000920_abnormal_myelination1.34599694
49* MP0004742_abnormal_vestibular_system1.34234539
50MP0004811_abnormal_neuron_physiology1.33429435
51* MP0002066_abnormal_motor_capabilities/c1.32811992
52MP0003880_abnormal_central_pattern1.32781866
53MP0003632_abnormal_nervous_system1.31798075
54* MP0002882_abnormal_neuron_morphology1.28242793
55MP0000955_abnormal_spinal_cord1.23159176
56MP0003136_yellow_coat_color1.20650800
57MP0001501_abnormal_sleep_pattern1.19612392
58MP0009780_abnormal_chondrocyte_physiolo1.19113754
59MP0003690_abnormal_glial_cell1.16027769
60MP0003634_abnormal_glial_cell1.15696559
61* MP0001963_abnormal_hearing_physiology1.15375921
62MP0000751_myopathy1.14704776
63MP0001348_abnormal_lacrimal_gland1.11226859
64MP0004142_abnormal_muscle_tone1.10603639
65MP0005645_abnormal_hypothalamus_physiol1.10585975
66MP0005647_abnormal_sex_gland1.08358380
67MP0000604_amyloidosis1.07676640
68* MP0002229_neurodegeneration1.05658328
69MP0002249_abnormal_larynx_morphology1.05201606
70MP0009643_abnormal_urine_homeostasis1.03818221
71MP0003646_muscle_fatigue1.03047220
72MP0005084_abnormal_gallbladder_morpholo1.01703070
73MP0006035_abnormal_mitochondrial_morpho1.01321968
74MP0005636_abnormal_mineral_homeostasis1.00627832
75MP0009764_decreased_sensitivity_to1.00480128
76MP0004510_myositis1.00377227
77MP0003329_amyloid_beta_deposits0.97652199
78MP0003656_abnormal_erythrocyte_physiolo0.97372296
79MP0000749_muscle_degeneration0.97116911
80MP0005451_abnormal_body_composition0.96982562
81MP0002184_abnormal_innervation0.96493641
82MP0006036_abnormal_mitochondrial_physio0.96481864
83MP0002152_abnormal_brain_morphology0.96024440
84MP0003724_increased_susceptibility_to0.94945837
85* MP0000026_abnormal_inner_ear0.90858391
86MP0001529_abnormal_vocalization0.90482377
87MP0004145_abnormal_muscle_electrophysio0.89863133
88MP0005670_abnormal_white_adipose0.89685182
89MP0002064_seizures0.89409414
90MP0002078_abnormal_glucose_homeostasis0.89151854
91MP0009765_abnormal_xenobiotic_induced0.86984034
92MP0003698_abnormal_male_reproductive0.86471488
93MP0000639_abnormal_adrenal_gland0.86288005
94MP0002638_abnormal_pupillary_reflex0.84410306
95MP0008469_abnormal_protein_level0.84286427
96MP0005376_homeostasis/metabolism_phenot0.83277078
97MP0001440_abnormal_grooming_behavior0.82898525
98MP0003137_abnormal_impulse_conducting0.82785068
99MP0009642_abnormal_blood_homeostasis0.81869946
100MP0000579_abnormal_nail_morphology0.81538956
101MP0008872_abnormal_physiological_respon0.81468848
102MP0009745_abnormal_behavioral_response0.80402369
103MP0002971_abnormal_brown_adipose0.80298977
104MP0004215_abnormal_myocardial_fiber0.80243291
105MP0009046_muscle_twitch0.77575752
106MP0005334_abnormal_fat_pad0.76726302
107MP0003186_abnormal_redox_activity0.76651633
108MP0009763_increased_sensitivity_to0.76533358
109MP0005646_abnormal_pituitary_gland0.76295036
110MP0004381_abnormal_hair_follicle0.76234147
111MP0000598_abnormal_liver_morphology0.74989086
112MP0008874_decreased_physiological_sensi0.74443928
113* MP0002752_abnormal_somatic_nervous0.74434625
114MP0009379_abnormal_foot_pigmentation0.74086633
115MP0003959_abnormal_lean_body0.73225264
116MP0001905_abnormal_dopamine_level0.73006571
117MP0005448_abnormal_energy_balance0.72863952
118MP0003011_delayed_dark_adaptation0.72436449
119MP0005423_abnormal_somatic_nervous0.70098688
120MP0003122_maternal_imprinting0.69523101
121MP0005379_endocrine/exocrine_gland_phen0.69306231
122MP0005408_hypopigmentation0.68833485
123MP0000747_muscle_weakness0.68455643
124MP0003638_abnormal_response/metabolism_0.67295627
125MP0005266_abnormal_metabolism0.67009882
126MP0001765_abnormal_ion_homeostasis0.65735632
127MP0001968_abnormal_touch/_nociception0.65481053
128MP0002234_abnormal_pharynx_morphology0.65301612
129MP0001346_abnormal_lacrimal_gland0.65073539
130MP0003635_abnormal_synaptic_transmissio0.63906445
131MP0003953_abnormal_hormone_level0.62614403
132MP0002837_dystrophic_cardiac_calcinosis0.62223484
133MP0005166_decreased_susceptibility_to0.61883357
134MP0001984_abnormal_olfaction0.61451907
135MP0004130_abnormal_muscle_cell0.61182944
136MP0005220_abnormal_exocrine_pancreas0.60282650
137MP0000569_abnormal_digit_pigmentation0.59616736
138MP0002572_abnormal_emotion/affect_behav0.58541540
139MP0003879_abnormal_hair_cell0.57461942
140MP0002272_abnormal_nervous_system0.57364598
141MP0005551_abnormal_eye_electrophysiolog0.57169191
142MP0001502_abnormal_circadian_rhythm0.55474256
143MP0002090_abnormal_vision0.55190837
144MP0002733_abnormal_thermal_nociception0.55016496
145* MP0004924_abnormal_behavior0.54378812
146* MP0005386_behavior/neurological_phenoty0.54378812
147MP0000230_abnormal_systemic_arterial0.53478542
148MP0002736_abnormal_nociception_after0.52760035
149MP0002069_abnormal_eating/drinking_beha0.48712404
150MP0002909_abnormal_adrenal_gland0.48319589
151MP0005595_abnormal_vascular_smooth0.48254378
152MP0003075_altered_response_to0.48198710
153MP0001943_abnormal_respiration0.46817113
154* MP0002067_abnormal_sensory_capabilities0.46313442
155MP0006082_CNS_inflammation0.46081014
156MP0002161_abnormal_fertility/fecundity0.45468383
157MP0010769_abnormal_survival0.45357815
158MP0003633_abnormal_nervous_system0.45170436
159MP0003861_abnormal_nervous_system0.44925220
160MP0000343_altered_response_to0.44559909
161MP0005620_abnormal_muscle_contractility0.44065790
162* MP0003956_abnormal_body_size0.43660167
163MP0004036_abnormal_muscle_relaxation0.43107188
164MP0004085_abnormal_heartbeat0.42415401
165MP0001177_atelectasis0.42366316
166MP0010768_mortality/aging0.41201066
167MP0000681_abnormal_thyroid_gland0.40446922

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.35320118
2Intrahepatic cholestasis (HP:0001406)6.42847088
3Deep venous thrombosis (HP:0002625)6.41307893
4Abnormality of binocular vision (HP:0011514)6.13870738
5Diplopia (HP:0000651)6.13870738
6Prolonged partial thromboplastin time (HP:0003645)5.96432364
7Myokymia (HP:0002411)5.89131826
8Hypobetalipoproteinemia (HP:0003563)5.66201668
9Abnormality of monocarboxylic acid metabolism (HP:0010996)5.63917441
10Xanthomatosis (HP:0000991)5.53491580
11Focal motor seizures (HP:0011153)5.42880507
12Hyperlipoproteinemia (HP:0010980)5.30030574
13Neurofibrillary tangles (HP:0002185)4.69184539
14Complement deficiency (HP:0004431)4.46282699
15Joint hemorrhage (HP:0005261)4.30792585
16Febrile seizures (HP:0002373)4.23348647
17Supranuclear gaze palsy (HP:0000605)4.22443769
18Action tremor (HP:0002345)4.15442540
19Atonic seizures (HP:0010819)4.05383004
20Degeneration of the lateral corticospinal tracts (HP:0002314)4.03956803
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.03956803
22Papilledema (HP:0001085)3.97408103
23Hyperammonemia (HP:0001987)3.95351163
24Ventricular fibrillation (HP:0001663)3.94793471
25Hyperglycinemia (HP:0002154)3.94562642
26Ketosis (HP:0001946)3.93538542
27Hypolipoproteinemia (HP:0010981)3.91941180
28Abnormality of the common coagulation pathway (HP:0010990)3.83982034
29Focal seizures (HP:0007359)3.79506804
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.77743058
31Fat malabsorption (HP:0002630)3.71012006
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.64675003
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.64095147
34Abnormality of methionine metabolism (HP:0010901)3.58888974
35Cerebral inclusion bodies (HP:0100314)3.57501846
36Epidermoid cyst (HP:0200040)3.53732430
37Abnormality of sulfur amino acid metabolism (HP:0004339)3.51610406
38Conjugated hyperbilirubinemia (HP:0002908)3.45915827
39Hyperglycinuria (HP:0003108)3.42004026
40Abnormality of the corticospinal tract (HP:0002492)3.40660092
41Abnormality of serine family amino acid metabolism (HP:0010894)3.38052070
42Abnormality of glycine metabolism (HP:0010895)3.38052070
43Ankle clonus (HP:0011448)3.37988344
44Spastic gait (HP:0002064)3.33112461
45Abnormality of the intrinsic pathway (HP:0010989)3.28145888
46Hemiparesis (HP:0001269)3.25447210
47Urinary urgency (HP:0000012)3.23314502
48Visual hallucinations (HP:0002367)3.21766964
49Hypoalphalipoproteinemia (HP:0003233)3.19088127
50Urinary bladder sphincter dysfunction (HP:0002839)3.16898914
51Epileptic encephalopathy (HP:0200134)3.15452537
52Abnormal eating behavior (HP:0100738)3.15124744
53Postural instability (HP:0002172)3.15019194
54Morphological abnormality of the pyramidal tract (HP:0002062)3.13997725
55Hypoglycemic coma (HP:0001325)3.13932468
56Spastic tetraparesis (HP:0001285)3.12371239
57Insidious onset (HP:0003587)3.11152139
58Termporal pattern (HP:0011008)3.11152139
59Dysmetria (HP:0001310)3.09728888
60Annular pancreas (HP:0001734)3.07460821
61Abnormality of complement system (HP:0005339)3.06315893
62Generalized tonic-clonic seizures (HP:0002069)3.01205840
63Intention tremor (HP:0002080)3.00942358
64Neuronal loss in central nervous system (HP:0002529)3.00742837
65Progressive cerebellar ataxia (HP:0002073)2.99095927
66Confusion (HP:0001289)2.98239333
67Impaired vibration sensation in the lower limbs (HP:0002166)2.96534019
68Hyperbilirubinemia (HP:0002904)2.96222242
69Cerebral edema (HP:0002181)2.92207856
70Ketoacidosis (HP:0001993)2.92122761
71Mutism (HP:0002300)2.91052179
72Delayed CNS myelination (HP:0002188)2.89595322
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.84492908
74Abnormality of pyrimidine metabolism (HP:0004353)2.83698744
75Hypercholesterolemia (HP:0003124)2.81298377
76Bronchomalacia (HP:0002780)2.81290259
77Delusions (HP:0000746)2.77646644
78Steatorrhea (HP:0002570)2.77485138
79Abnormality of fatty-acid metabolism (HP:0004359)2.77445723
80Spontaneous abortion (HP:0005268)2.75382905
81Abnormal pupillary function (HP:0007686)2.73738685
82Hemiplegia (HP:0002301)2.73121840
83Lethargy (HP:0001254)2.71210568
84Absence seizures (HP:0002121)2.67759990
85Gout (HP:0001997)2.62832205
86Metabolic acidosis (HP:0001942)2.59753890
87Neonatal onset (HP:0003623)2.56796272
88Peripheral hypomyelination (HP:0007182)2.56760381
89Abnormality of serum amino acid levels (HP:0003112)2.56697614
90Exercise-induced muscle cramps (HP:0003710)2.53082486
91Ulnar claw (HP:0001178)2.52172938
92Abnormality of nucleobase metabolism (HP:0010932)2.51919892
93Stereotypic behavior (HP:0000733)2.49015263
94Dialeptic seizures (HP:0011146)2.48518977
95Abnormal gallbladder physiology (HP:0012438)2.47797246
96Cholecystitis (HP:0001082)2.47797246
97Cerebral hypomyelination (HP:0006808)2.46985309
98Hypoglycemic seizures (HP:0002173)2.45394682
99Hypochromic microcytic anemia (HP:0004840)2.41866392
100Global brain atrophy (HP:0002283)2.40765626
101Dicarboxylic aciduria (HP:0003215)2.40442135
102Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40442135
103Brushfield spots (HP:0001088)2.40221235
104Dysdiadochokinesis (HP:0002075)2.38635607
105Apathy (HP:0000741)2.37833643
106Skin nodule (HP:0200036)2.36453762
107Bradykinesia (HP:0002067)2.36216180
108Abnormality of purine metabolism (HP:0004352)2.36030466
109Tetraplegia (HP:0002445)2.34715720
110Rigidity (HP:0002063)2.34574223
111Abnormal gallbladder morphology (HP:0012437)2.33832086
112Depression (HP:0000716)2.33126955
113Poor eye contact (HP:0000817)2.33058052
114Muscle fiber inclusion bodies (HP:0100299)2.32972357
115Muscle fiber splitting (HP:0003555)2.32253437
116Irritability (HP:0000737)2.32091810
117Acanthocytosis (HP:0001927)2.32048753
118Obstructive sleep apnea (HP:0002870)2.29346640
119Sensorimotor neuropathy (HP:0007141)2.28582987
120Amyloidosis (HP:0011034)2.26536171
121Menorrhagia (HP:0000132)2.25162704
122Cholelithiasis (HP:0001081)2.24402793
123Vascular calcification (HP:0004934)2.24029886
124Diminished motivation (HP:0000745)2.23637780
125Nemaline bodies (HP:0003798)2.23130863
126Late onset (HP:0003584)2.22240166
127Hepatocellular carcinoma (HP:0001402)2.21766852
128Spastic paraparesis (HP:0002313)2.21624896
129Sleep apnea (HP:0010535)2.20512645
130Lower limb muscle weakness (HP:0007340)2.19363840
131Rapidly progressive (HP:0003678)2.18927718
132Polyphagia (HP:0002591)2.18468391
133Status epilepticus (HP:0002133)2.15636147
134Truncal ataxia (HP:0002078)2.15443195
135Scanning speech (HP:0002168)2.15114880
136Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.14851881
137Acute encephalopathy (HP:0006846)2.13685442
138Exercise-induced myalgia (HP:0003738)2.12760994
139Bundle branch block (HP:0011710)2.08930789
140Vomiting (HP:0002013)2.06815120
141Enlarged kidneys (HP:0000105)2.06241059
142Insomnia (HP:0100785)2.06183538
143Malnutrition (HP:0004395)2.05464857
144Clonus (HP:0002169)2.05270122
145Increased circulating renin level (HP:0000848)2.04689593
146Myocardial infarction (HP:0001658)2.04454857
147Glomerulonephritis (HP:0000099)2.04142606
148Abnormal EKG (HP:0003115)2.02332148
149Cerebral hemorrhage (HP:0001342)2.01924992
150Bowel incontinence (HP:0002607)2.01191940
151Myotonia (HP:0002486)2.00953150
152Abnormal ciliary motility (HP:0012262)1.98982250
153Abnormal social behavior (HP:0012433)1.97856261
154Impaired social interactions (HP:0000735)1.97856261
155Slow saccadic eye movements (HP:0000514)1.96576488
156Glycosuria (HP:0003076)1.96572179
157Abnormality of urine glucose concentration (HP:0011016)1.96572179
158Foot dorsiflexor weakness (HP:0009027)1.95884621
159Prolonged QT interval (HP:0001657)1.95816043
160Amblyopia (HP:0000646)1.95749652
161Alkalosis (HP:0001948)1.95672911
162Axonal loss (HP:0003447)1.95165948
163Hepatic necrosis (HP:0002605)1.95002039
164Epileptiform EEG discharges (HP:0011182)1.94698581
165Nuclear cataract (HP:0100018)1.94322389
166Hypothermia (HP:0002045)1.92761516
167Syncope (HP:0001279)1.92252427
168Fair hair (HP:0002286)1.92190438
169Lipid accumulation in hepatocytes (HP:0006561)1.91552742
170Cardiovascular calcification (HP:0011915)1.91240449
171Mitral stenosis (HP:0001718)1.91200692
172Increased muscle lipid content (HP:0009058)1.91194463
173Gingival bleeding (HP:0000225)1.90603799
174Incomplete penetrance (HP:0003829)1.90341139
175Abnormal large intestine physiology (HP:0012700)1.90121432
176Turricephaly (HP:0000262)1.89917907
177Limb dystonia (HP:0002451)1.88754331
178Hyporeflexia of lower limbs (HP:0002600)1.87579812
179Acute hepatic failure (HP:0006554)1.85567367
180Hyperphosphaturia (HP:0003109)1.84129152
181Spastic diplegia (HP:0001264)1.83888441
182Systemic lupus erythematosus (HP:0002725)1.83695570
183Rickets (HP:0002748)1.83595920
184Abnormality of the gallbladder (HP:0005264)1.83070525
185Increased intramyocellular lipid droplets (HP:0012240)1.82664921
186Segmental peripheral demyelination/remyelination (HP:0003481)1.82027445
187Double outlet right ventricle (HP:0001719)1.80749211
188Congenital malformation of the right heart (HP:0011723)1.80749211
189Abnormality of the foot musculature (HP:0001436)1.80403188
190Thrombophlebitis (HP:0004418)1.80264599
191Urinary incontinence (HP:0000020)1.79680101
192Dynein arm defect of respiratory motile cilia (HP:0012255)1.79636415
193Hepatocellular necrosis (HP:0001404)1.77596075
194Pancreatitis (HP:0001733)1.77150905
195Hyperinsulinemic hypoglycemia (HP:0000825)1.76836790
196Symptomatic seizures (HP:0011145)1.75342958
197Renal Fanconi syndrome (HP:0001994)1.74729195
198Abnormality of vitamin metabolism (HP:0100508)1.74051002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.23116617
2EPHA43.90848979
3FGFR43.45946739
4MAP2K43.14238494
5PAK62.95270720
6PRKD32.63216879
7SIK12.60341550
8MAP3K122.59203687
9PHKG22.29829683
10PHKG12.29829683
11TNIK2.19390456
12INSRR2.17389866
13PNCK2.12796602
14PRPF4B2.12302870
15CAMKK12.09147829
16TAOK32.06770499
17TESK12.01114347
18NTRK21.93886278
19PIK3CG1.90200955
20LATS21.79270232
21NEK61.78921302
22MAP3K131.76390955
23MAP3K41.73589695
24MAP2K71.73103863
25MAPK131.72161534
26NTRK31.69591064
27CAMKK21.68187133
28TAOK11.64745355
29ERBB41.61759757
30TYK21.59243331
31CASK1.54904622
32ERN11.53953634
33PLK21.51551010
34MAPK151.49561550
35DAPK21.49265360
36TYRO31.47445874
37MARK21.45799262
38GRK71.40182843
39CAMK41.39356281
40RIPK11.30925589
41GRK61.27810177
42OBSCN1.26966666
43STK381.26202114
44ADRBK21.24549729
45MAPKAPK51.23519817
46CDK51.21599673
47CSNK1G11.21530157
48CSNK1G31.18721179
49PKN21.14315080
50CAMK2G1.11946511
51MST1R1.11692627
52ARAF1.10381518
53TNK21.10170817
54KSR21.09962580
55CAMK2A1.07751569
56PINK11.07297586
57WNK31.05367069
58CSNK1G21.02419942
59IRAK21.01587775
60MAP3K71.01425348
61JAK20.99932088
62FLT30.98814741
63PAK30.96028908
64PLK40.91599221
65IRAK10.91325658
66OXSR10.90899011
67MINK10.90739682
68CDK140.90732312
69NME10.90624856
70NLK0.88300106
71CAMK1G0.87261148
72CDK11A0.87092593
73WNK40.86953250
74MAP3K10.85866023
75CDK150.85506867
76MAPK110.85485545
77MUSK0.84579167
78MAPK120.83634927
79CDK180.82698456
80ROCK20.82482135
81PRKCG0.78774873
82GRK50.78512903
83IKBKE0.77979929
84DYRK1A0.76840701
85BMPR20.74351593
86MAPK40.73601936
87MAP2K60.72626948
88TAOK20.72391335
89PTK60.72199768
90TXK0.71645033
91SGK30.71433531
92CAMK2B0.70867752
93SGK10.70855667
94NTRK10.70817029
95JAK10.70809092
96PRKCZ0.70420880
97RIPK40.69640100
98MOS0.69086162
99PRKCQ0.69018199
100PRKAA20.68739993
101RET0.67993275
102MAPK100.67179026
103FES0.66835525
104SIK20.66825531
105MAP3K90.66104954
106BRAF0.65829297
107MAP3K110.64818439
108PRKCH0.63904483
109PDK10.62774232
110ADRBK10.61176302
111ABL20.60969246
112STK390.59586994
113PRKACG0.59174310
114BMPR1B0.59048224
115PDPK10.59029186
116PKN10.56926423
117DDR20.56743797
118STK110.56656518
119SGK2230.56387643
120SGK4940.56387643
121TBK10.56310426
122CAMK10.55895547
123LIMK10.53233989
124DAPK10.53178377
125KDR0.52565023
126MARK10.51594716
127UHMK10.51565300
128CAMK2D0.50208195
129EPHB10.50166952
130ZAP700.50098260
131SGK20.49920664
132PRKG10.48409846
133CDK190.48008401
134TEC0.47779267
135TIE10.47389434
136DYRK30.47298168
137PRKACA0.47122077
138IGF1R0.45547240
139ALK0.44674984
140DYRK1B0.44580096
141GSK3A0.44345937
142ITK0.43772872
143PRKCA0.43668324
144RPS6KA30.43647349
145MAPK70.42584087
146FGFR20.42520176
147BMX0.41761977
148DAPK30.41669357
149MAP3K140.41342607
150ROCK10.39341913
151PTK2B0.38246992
152ICK0.36520597
153LMTK20.32639694
154FYN0.32408331
155MAPK80.31255523
156WNK10.30027079

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.37983991
2Nitrogen metabolism_Homo sapiens_hsa009103.29762387
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10980877
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09959152
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.00253400
6Circadian entrainment_Homo sapiens_hsa047132.88705884
7Arginine biosynthesis_Homo sapiens_hsa002202.79970675
8Long-term potentiation_Homo sapiens_hsa047202.66577757
9Tryptophan metabolism_Homo sapiens_hsa003802.66093287
10Glutamatergic synapse_Homo sapiens_hsa047242.51858235
11Amphetamine addiction_Homo sapiens_hsa050312.50369093
12Gastric acid secretion_Homo sapiens_hsa049712.44470633
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42895158
14Complement and coagulation cascades_Homo sapiens_hsa046102.42000178
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31398840
16Insulin secretion_Homo sapiens_hsa049112.29457787
17Histidine metabolism_Homo sapiens_hsa003402.27966662
18Butanoate metabolism_Homo sapiens_hsa006502.27627313
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25989160
20Fatty acid degradation_Homo sapiens_hsa000712.23085840
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20165463
22Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09103539
23Peroxisome_Homo sapiens_hsa041462.04759731
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04083261
25Phenylalanine metabolism_Homo sapiens_hsa003601.92348950
26Cholinergic synapse_Homo sapiens_hsa047251.90169441
27Propanoate metabolism_Homo sapiens_hsa006401.89585247
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.87299651
29Chemical carcinogenesis_Homo sapiens_hsa052041.86214758
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82347520
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81729898
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79866823
33Dopaminergic synapse_Homo sapiens_hsa047281.77615063
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.75851463
35Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.74971038
36beta-Alanine metabolism_Homo sapiens_hsa004101.74686317
37Tyrosine metabolism_Homo sapiens_hsa003501.73416045
38Fatty acid metabolism_Homo sapiens_hsa012121.71611958
39PPAR signaling pathway_Homo sapiens_hsa033201.71386875
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70948905
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68871680
42Calcium signaling pathway_Homo sapiens_hsa040201.66210395
43Fatty acid elongation_Homo sapiens_hsa000621.64527048
44Oxytocin signaling pathway_Homo sapiens_hsa049211.57528262
45Bile secretion_Homo sapiens_hsa049761.57066443
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53528332
47Sulfur metabolism_Homo sapiens_hsa009201.53167908
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50154626
49Retinol metabolism_Homo sapiens_hsa008301.49810464
50Pyruvate metabolism_Homo sapiens_hsa006201.47050324
51cAMP signaling pathway_Homo sapiens_hsa040241.44662071
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43218753
53Salivary secretion_Homo sapiens_hsa049701.41712106
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.41487385
55Staphylococcus aureus infection_Homo sapiens_hsa051501.37628812
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37359684
57Dorso-ventral axis formation_Homo sapiens_hsa043201.34743081
58Estrogen signaling pathway_Homo sapiens_hsa049151.28733203
59Starch and sucrose metabolism_Homo sapiens_hsa005001.23181210
60Caffeine metabolism_Homo sapiens_hsa002321.23082085
61Olfactory transduction_Homo sapiens_hsa047401.19291542
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.16893430
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16830033
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16213164
65Melanogenesis_Homo sapiens_hsa049161.13612632
66Sulfur relay system_Homo sapiens_hsa041221.13013492
67Folate biosynthesis_Homo sapiens_hsa007901.12334054
68Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10957929
69GnRH signaling pathway_Homo sapiens_hsa049121.07778788
70ABC transporters_Homo sapiens_hsa020101.06326431
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02816189
72Steroid biosynthesis_Homo sapiens_hsa001001.00118653
73Glioma_Homo sapiens_hsa052140.98581529
74Fat digestion and absorption_Homo sapiens_hsa049750.97240437
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94053825
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.93673713
77Gap junction_Homo sapiens_hsa045400.93616572
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.93151328
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.92326707
80Selenocompound metabolism_Homo sapiens_hsa004500.92234954
81Arginine and proline metabolism_Homo sapiens_hsa003300.92017745
82Carbon metabolism_Homo sapiens_hsa012000.91396622
83ErbB signaling pathway_Homo sapiens_hsa040120.89685091
84Oxidative phosphorylation_Homo sapiens_hsa001900.87760295
85Biosynthesis of amino acids_Homo sapiens_hsa012300.86545027
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84988135
87Vitamin digestion and absorption_Homo sapiens_hsa049770.79799011
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79502998
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.77636552
90MAPK signaling pathway_Homo sapiens_hsa040100.75621872
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75270939
92Inositol phosphate metabolism_Homo sapiens_hsa005620.75001638
93Endocytosis_Homo sapiens_hsa041440.72831657
94Long-term depression_Homo sapiens_hsa047300.71911720
95VEGF signaling pathway_Homo sapiens_hsa043700.70347206
96Axon guidance_Homo sapiens_hsa043600.70333512
97Pancreatic secretion_Homo sapiens_hsa049720.70177361
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.68126272
99Phototransduction_Homo sapiens_hsa047440.68033649
100Oocyte meiosis_Homo sapiens_hsa041140.66666169
101Glycerolipid metabolism_Homo sapiens_hsa005610.66412911
102Rap1 signaling pathway_Homo sapiens_hsa040150.65985057
103Parkinsons disease_Homo sapiens_hsa050120.64318303
104Ras signaling pathway_Homo sapiens_hsa040140.64192088
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64147457
106Circadian rhythm_Homo sapiens_hsa047100.60688939
107Dilated cardiomyopathy_Homo sapiens_hsa054140.60482909
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58533848
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58003921
110Type II diabetes mellitus_Homo sapiens_hsa049300.57994941
111Renal cell carcinoma_Homo sapiens_hsa052110.56550093
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55209302
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53899716
114Metabolic pathways_Homo sapiens_hsa011000.53618218
115Glutathione metabolism_Homo sapiens_hsa004800.51242569
116Nicotine addiction_Homo sapiens_hsa050330.50880890
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50620322
118Vitamin B6 metabolism_Homo sapiens_hsa007500.50421941
119Lysine degradation_Homo sapiens_hsa003100.50178651
120Vibrio cholerae infection_Homo sapiens_hsa051100.48881634
121Fatty acid biosynthesis_Homo sapiens_hsa000610.46757073
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44684821
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44128779
124Prion diseases_Homo sapiens_hsa050200.42153993
125HIF-1 signaling pathway_Homo sapiens_hsa040660.41361233
126Alzheimers disease_Homo sapiens_hsa050100.41146997
127GABAergic synapse_Homo sapiens_hsa047270.40738709
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36566228
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.36186129
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34614368
131Choline metabolism in cancer_Homo sapiens_hsa052310.33352100
132Tight junction_Homo sapiens_hsa045300.33063267
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31717886
134Chemokine signaling pathway_Homo sapiens_hsa040620.30806921
135Pentose phosphate pathway_Homo sapiens_hsa000300.29562433
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.29324577
137Cocaine addiction_Homo sapiens_hsa050300.28845064
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28388625
139Alcoholism_Homo sapiens_hsa050340.28261176
140Wnt signaling pathway_Homo sapiens_hsa043100.26890403
141Insulin signaling pathway_Homo sapiens_hsa049100.26400983
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24136153
143Endometrial cancer_Homo sapiens_hsa052130.23162785
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23140868
145Collecting duct acid secretion_Homo sapiens_hsa049660.16442947
146Linoleic acid metabolism_Homo sapiens_hsa005910.15649841
147Glucagon signaling pathway_Homo sapiens_hsa049220.15257571
148Huntingtons disease_Homo sapiens_hsa050160.14905116
149One carbon pool by folate_Homo sapiens_hsa006700.14440568
150Galactose metabolism_Homo sapiens_hsa000520.14280159
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.14114789
152Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.10792225
153Synaptic vesicle cycle_Homo sapiens_hsa047210.10503899
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10446772
155Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10227911
156Ovarian steroidogenesis_Homo sapiens_hsa049130.08830064
157Serotonergic synapse_Homo sapiens_hsa047260.06834773
158Taste transduction_Homo sapiens_hsa047420.05122833
159African trypanosomiasis_Homo sapiens_hsa051430.03812121
160Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02640393
161Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.01734948
162Thyroid hormone synthesis_Homo sapiens_hsa049180.01715340
163Cardiac muscle contraction_Homo sapiens_hsa042600.01426438
164Renin secretion_Homo sapiens_hsa049240.01352157
165Fructose and mannose metabolism_Homo sapiens_hsa000510.00637810
166Morphine addiction_Homo sapiens_hsa050320.00016360
167Insulin resistance_Homo sapiens_hsa04931-0.0117594
168Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0116053

Most similar genes based on co-expression Upload to Enrichr

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