TMIGD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.87718484
2urate metabolic process (GO:0046415)9.51081622
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.72964860
4drug transport (GO:0015893)8.30534100
5regulation of guanylate cyclase activity (GO:0031282)8.10830812
6aminoglycoside antibiotic metabolic process (GO:0030647)7.86037110
7drug catabolic process (GO:0042737)7.48892285
8phosphate ion transport (GO:0006817)7.27868177
9lipoprotein transport (GO:0042953)7.21529813
10exogenous drug catabolic process (GO:0042738)6.96491017
11organic cation transport (GO:0015695)6.88722060
12lysine catabolic process (GO:0006554)6.86492648
13lysine metabolic process (GO:0006553)6.86492648
14epoxygenase P450 pathway (GO:0019373)6.86410312
15fat-soluble vitamin biosynthetic process (GO:0042362)6.68727865
16phosphate ion transmembrane transport (GO:0035435)6.39346624
17positive regulation of guanylate cyclase activity (GO:0031284)6.21671085
18quaternary ammonium group transport (GO:0015697)6.04275091
19cysteine metabolic process (GO:0006534)5.87164065
20regulation of systemic arterial blood pressure by hormone (GO:0001990)5.66332009
21regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.66332009
22endocrine process (GO:0050886)5.66332009
23nonribosomal peptide biosynthetic process (GO:0019184)5.54588550
24modified amino acid transport (GO:0072337)5.46719571
25homocysteine metabolic process (GO:0050667)5.46649675
26glyoxylate metabolic process (GO:0046487)5.42685348
27hormone catabolic process (GO:0042447)5.32591637
28glutathione biosynthetic process (GO:0006750)5.12431335
29renal absorption (GO:0070293)5.08802781
30regulation of bile acid biosynthetic process (GO:0070857)5.07222138
31excretion (GO:0007588)5.06736516
32regulation of systemic arterial blood pressure (GO:0003073)5.06477876
33bile acid and bile salt transport (GO:0015721)5.00878141
34virion attachment to host cell (GO:0019062)4.92586262
35adhesion of symbiont to host cell (GO:0044650)4.92586262
36regulation of cGMP biosynthetic process (GO:0030826)4.91102634
37regulation of cellular extravasation (GO:0002691)4.89969511
38receptor guanylyl cyclase signaling pathway (GO:0007168)4.87406484
39vitamin D metabolic process (GO:0042359)4.84123328
40short-chain fatty acid metabolic process (GO:0046459)4.81435284
41response to mercury ion (GO:0046689)4.78318442
42regulation of triglyceride catabolic process (GO:0010896)4.76608627
43tricarboxylic acid metabolic process (GO:0072350)4.73047858
44amino-acid betaine transport (GO:0015838)4.71569017
45carnitine transport (GO:0015879)4.71569017
46renal system process involved in regulation of blood volume (GO:0001977)4.64053420
47sulfur compound transport (GO:0072348)4.60915790
48diacylglycerol metabolic process (GO:0046339)4.59903677
49intestinal absorption (GO:0050892)4.56989090
50urea cycle (GO:0000050)4.52852837
51phosphate ion homeostasis (GO:0055062)4.51459594
52trivalent inorganic anion homeostasis (GO:0072506)4.51459594
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.51047474
54very-low-density lipoprotein particle assembly (GO:0034379)4.48151260
55toxin transport (GO:1901998)4.41381085
56aspartate family amino acid catabolic process (GO:0009068)4.40100352
57peptide hormone processing (GO:0016486)4.39759268
58sulfur amino acid catabolic process (GO:0000098)4.37157672
59regulation of vitamin metabolic process (GO:0030656)4.36493007
60UDP-N-acetylglucosamine metabolic process (GO:0006047)4.35730350
61digestion (GO:0007586)4.32406488
62urea metabolic process (GO:0019627)4.30487862
63fructose metabolic process (GO:0006000)4.22977221
64adhesion of symbiont to host (GO:0044406)4.17981566
65glycolipid catabolic process (GO:0019377)4.15968601
66fatty acid beta-oxidation (GO:0006635)4.13930017
67glycosphingolipid catabolic process (GO:0046479)4.13664816
68peptide biosynthetic process (GO:0043043)4.11283916
69vitamin A metabolic process (GO:0006776)4.09125210
70regulation of cGMP metabolic process (GO:0030823)4.08234739
71branched-chain amino acid metabolic process (GO:0009081)4.07509234
72sulfate transmembrane transport (GO:1902358)4.04561321
73vitamin transport (GO:0051180)4.01786405
74amino-acid betaine metabolic process (GO:0006577)4.00432851
75plasma lipoprotein particle assembly (GO:0034377)3.99221709
76cellular ketone body metabolic process (GO:0046950)3.97103049
77nitrogen cycle metabolic process (GO:0071941)3.96087427
78flavonoid metabolic process (GO:0009812)3.95241280
79angiotensin maturation (GO:0002003)3.89261831
80oligosaccharide catabolic process (GO:0009313)3.87589137
81peptide catabolic process (GO:0043171)3.87544857
82metanephric tubule development (GO:0072170)3.87203729
83metanephric nephron tubule development (GO:0072234)3.87203729
84serine family amino acid catabolic process (GO:0009071)3.85962097
85drug metabolic process (GO:0017144)3.85197284
86L-phenylalanine metabolic process (GO:0006558)3.84178078
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.84178078
88serine family amino acid metabolic process (GO:0009069)3.84114607
89NADH metabolic process (GO:0006734)3.84055391
90actin filament depolymerization (GO:0030042)3.82828168
91fatty acid oxidation (GO:0019395)3.80395608
92cellular response to nitric oxide (GO:0071732)3.78385966
93valine metabolic process (GO:0006573)3.78167548
94maintenance of gastrointestinal epithelium (GO:0030277)3.75398034
95antibacterial humoral response (GO:0019731)3.74398386
96drinking behavior (GO:0042756)3.73713047
97lipid oxidation (GO:0034440)3.72535182
98glycoside metabolic process (GO:0016137)3.72209927
99glutathione metabolic process (GO:0006749)3.71549788
100carnitine metabolic process (GO:0009437)3.71428805
101L-phenylalanine catabolic process (GO:0006559)3.71166745
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.71166745
103positive regulation of pseudopodium assembly (GO:0031274)3.70676522
104positive regulation of glycoprotein biosynthetic process (GO:0010560)3.69369482
105alkaloid metabolic process (GO:0009820)3.68971629
106cellular modified amino acid catabolic process (GO:0042219)3.68406502
107protein-lipid complex assembly (GO:0065005)3.64660152
108fat-soluble vitamin metabolic process (GO:0006775)3.64651373
109antimicrobial humoral response (GO:0019730)3.63439699
110aromatic amino acid family catabolic process (GO:0009074)3.63318427
111regulation of cholesterol homeostasis (GO:2000188)3.60559245
112lipoprotein metabolic process (GO:0042157)3.60155106
113neurotransmitter biosynthetic process (GO:0042136)3.59397945
114positive regulation of cGMP biosynthetic process (GO:0030828)3.57742346
115cGMP biosynthetic process (GO:0006182)3.57547994
116metanephric nephron epithelium development (GO:0072243)3.53784825
117proline metabolic process (GO:0006560)3.53482441
118tryptophan catabolic process (GO:0006569)3.52194581
119indole-containing compound catabolic process (GO:0042436)3.52194581
120indolalkylamine catabolic process (GO:0046218)3.52194581
121transepithelial transport (GO:0070633)3.47441549
122fatty acid catabolic process (GO:0009062)3.46677393
1232-oxoglutarate metabolic process (GO:0006103)3.46649408
124glutamine family amino acid biosynthetic process (GO:0009084)3.46462171
125cGMP-mediated signaling (GO:0019934)3.44712850
126glutathione derivative metabolic process (GO:1901685)3.40146431
127glutathione derivative biosynthetic process (GO:1901687)3.40146431
128ketone body metabolic process (GO:1902224)3.39832382
129glycosylceramide metabolic process (GO:0006677)3.38515749
130tryptophan metabolic process (GO:0006568)3.38203895
131nucleoside diphosphate biosynthetic process (GO:0009133)3.36670060
132response to phenylpropanoid (GO:0080184)3.36583080
133response to nitric oxide (GO:0071731)3.34181061
134ceramide catabolic process (GO:0046514)3.33506281
135branched-chain amino acid catabolic process (GO:0009083)3.33031425
136amino acid transmembrane transport (GO:0003333)3.32140882
137positive regulation of glycoprotein metabolic process (GO:1903020)3.32102691
138uronic acid metabolic process (GO:0006063)3.31986259
139glucuronate metabolic process (GO:0019585)3.31986259
140regulation of pseudopodium assembly (GO:0031272)3.31668366
141bile acid metabolic process (GO:0008206)3.31334302
142cellular response to reactive nitrogen species (GO:1902170)3.30021079
143positive regulation of lipid catabolic process (GO:0050996)3.30003943
144vitamin biosynthetic process (GO:0009110)3.29869548
145phospholipid efflux (GO:0033700)3.29823911
146sphingomyelin metabolic process (GO:0006684)3.29399543
147digestive system process (GO:0022600)3.29003240
148acetyl-CoA metabolic process (GO:0006084)3.28593961
149glycerol metabolic process (GO:0006071)3.27679575
150renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.27493762
151sodium ion transport (GO:0006814)3.27470534
152purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.26829023
1533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.26829023
154transcytosis (GO:0045056)3.26726484
155sulfate transport (GO:0008272)3.26492058
156vitamin transmembrane transport (GO:0035461)3.25788817
157phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.25711063
158polyol transport (GO:0015791)3.22632240
159arginine metabolic process (GO:0006525)3.20128546
160response to growth hormone (GO:0060416)3.19019343
161sphingolipid catabolic process (GO:0030149)3.18796733
162metanephric epithelium development (GO:0072207)3.17988992
163cobalamin metabolic process (GO:0009235)3.16895464
164beta-amyloid metabolic process (GO:0050435)3.16298177
165cellular response to vitamin D (GO:0071305)3.16250614
166regulation of cholesterol esterification (GO:0010872)3.15451194
167cellular glucuronidation (GO:0052695)3.14281463
168sulfur amino acid metabolic process (GO:0000096)3.13985630
169mRNA modification (GO:0016556)3.13693100
170cytidine metabolic process (GO:0046087)3.10113712
171cytidine catabolic process (GO:0006216)3.10113712
172cytidine deamination (GO:0009972)3.10113712
173positive regulation of cGMP metabolic process (GO:0030825)3.10075046
174positive regulation of triglyceride lipase activity (GO:0061365)3.09424905
175positive regulation of lipoprotein lipase activity (GO:0051006)3.09424905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.90672477
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.20686080
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.14790162
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.00755044
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.63577052
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.42056948
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.36625982
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.20669313
9ESR1_21235772_ChIP-Seq_MCF-7_Human3.04806560
10* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.95983497
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.89101016
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.83901017
13AR_21909140_ChIP-Seq_LNCAP_Human2.74626380
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73517097
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.70766709
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.58383074
17GATA4_25053715_ChIP-Seq_YYC3_Human2.56248694
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.36370361
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.32052088
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.25684542
21* GATA6_25053715_ChIP-Seq_YYC3_Human2.23825833
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20395443
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.19754925
24CLOCK_20551151_ChIP-Seq_293T_Human2.16104567
25GATA1_22025678_ChIP-Seq_K562_Human2.14035360
26SOX2_20726797_ChIP-Seq_SW620_Human2.07998799
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94837011
28NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86746516
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81214847
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.79121910
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.74280174
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.74202045
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72726120
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72347882
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.69689859
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69526670
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66743511
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.64754057
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63889236
40RACK7_27058665_Chip-Seq_MCF-7_Human1.63213142
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62879015
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.62205794
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54667358
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48328846
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47138510
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46751049
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.38886621
48VDR_22108803_ChIP-Seq_LS180_Human1.38847564
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37984804
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37883605
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.36494140
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33613652
53* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32559409
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31372604
55EGR1_19032775_ChIP-ChIP_M12_Human1.28872731
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.24135919
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22455971
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21179256
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20798266
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20796262
61ATF3_27146783_Chip-Seq_COLON_Human1.18764675
62RXR_22108803_ChIP-Seq_LS180_Human1.18047785
63* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16438670
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16213183
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14620756
66BCL6_27268052_Chip-Seq_Bcells_Human1.11354408
67SA1_27219007_Chip-Seq_Bcells_Human1.10223500
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10003783
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09998320
70CDX2_22108803_ChIP-Seq_LS180_Human1.09840159
71GATA2_19941826_ChIP-Seq_K562_Human1.09505803
72JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07670877
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06296936
74BCOR_27268052_Chip-Seq_Bcells_Human1.05364990
75* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04241366
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.03268111
77ZNF263_19887448_ChIP-Seq_K562_Human1.02763784
78FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01028606
79KLF5_25053715_ChIP-Seq_YYC3_Human1.00955377
80LXR_22292898_ChIP-Seq_THP-1_Human1.00204428
81NANOG_20526341_ChIP-Seq_ESCs_Human1.00090381
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99564967
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.98943547
84CEBPB_22108803_ChIP-Seq_LS180_Human0.97670212
85GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96376269
86CREB1_26743006_Chip-Seq_LNCaP_Human0.96312894
87KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95697430
88NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95361177
89* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93327801
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93068611
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.92583345
92MYC_19915707_ChIP-ChIP_AK7_Human0.90897892
93CTCF_27219007_Chip-Seq_Bcells_Human0.89801138
94ESR1_20079471_ChIP-ChIP_T-47D_Human0.89633880
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89133674
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88264506
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88252233
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88236864
99STAT1_20625510_ChIP-Seq_HELA_Human0.86092908
100GATA3_24758297_ChIP-Seq_MCF-7_Human0.85584987
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85521597
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84830834
103ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83965791
104* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83661960
105* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83295264
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82862697
107FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82818161
108SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82592350
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82569745
110VDR_24763502_ChIP-Seq_THP-1_Human0.82457516
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82197221
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81799028
113FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80060128
114* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79749836
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79621092
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78177884
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.78122513
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77926117
119* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77612369
120* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.77377720
121VDR_24787735_ChIP-Seq_THP-1_Human0.77286039
122DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76937721
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76053081
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75654734
125* FOXA1_25552417_ChIP-Seq_VCAP_Human0.75072461
126HIF1A_21447827_ChIP-Seq_MCF-7_Human0.75030347
127TP63_23658742_ChIP-Seq_EP156T_Human0.74045588
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73460889
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72661100
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.70963001
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.70784636
132* TBX20_22328084_ChIP-Seq_HEART_Mouse0.70557880
133* TBX20_22080862_ChIP-Seq_HEART_Mouse0.70557880
134GATA1_19941826_ChIP-Seq_K562_Human0.69337003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.82725975
2MP0004043_abnormal_pH_regulation4.95942186
3MP0002139_abnormal_hepatobiliary_system4.15785308
4MP0004019_abnormal_vitamin_homeostasis4.05576430
5MP0005332_abnormal_amino_acid3.91492381
6MP0005085_abnormal_gallbladder_physiolo3.70406191
7MP0009379_abnormal_foot_pigmentation3.58334653
8MP0005377_hearing/vestibular/ear_phenot3.50719561
9MP0003878_abnormal_ear_physiology3.50719561
10MP0005365_abnormal_bile_salt3.38241286
11MP0009643_abnormal_urine_homeostasis3.38073190
12MP0009840_abnormal_foam_cell3.33138629
13MP0001765_abnormal_ion_homeostasis3.19858327
14MP0008875_abnormal_xenobiotic_pharmacok3.01863051
15MP0010234_abnormal_vibrissa_follicle2.95337311
16MP0002138_abnormal_hepatobiliary_system2.84833543
17MP0001666_abnormal_nutrient_absorption2.78023960
18MP0003252_abnormal_bile_duct2.67693144
19MP0005636_abnormal_mineral_homeostasis2.63436937
20MP0004264_abnormal_extraembryonic_tissu2.59814845
21MP0003195_calcinosis2.44343670
22MP0001756_abnormal_urination2.41294148
23MP0002136_abnormal_kidney_physiology2.34758243
24MP0005409_darkened_coat_color2.18244473
25MP0000538_abnormal_urinary_bladder2.08544467
26MP0004147_increased_porphyrin_level1.90262919
27MP0005084_abnormal_gallbladder_morpholo1.72244189
28MP0005058_abnormal_lysosome_morphology1.68182164
29MP0002876_abnormal_thyroid_physiology1.64192538
30MP0001958_emphysema1.62414364
31MP0003300_gastrointestinal_ulcer1.60569316
32MP0003191_abnormal_cellular_cholesterol1.51578032
33MP0003866_abnormal_defecation1.43867790
34MP0001188_hyperpigmentation1.43598963
35MP0005451_abnormal_body_composition1.42314693
36MP0002822_catalepsy1.40473901
37MP0003806_abnormal_nucleotide_metabolis1.39446817
38MP0005584_abnormal_enzyme/coenzyme_acti1.25508235
39MP0008961_abnormal_basal_metabolism1.23992855
40MP0004885_abnormal_endolymph1.23674607
41MP0002796_impaired_skin_barrier1.23535480
42MP0001663_abnormal_digestive_system1.23183230
43MP0005319_abnormal_enzyme/_coenzyme1.21846053
44MP0000462_abnormal_digestive_system1.15694553
45MP0003718_maternal_effect1.14093473
46MP0005381_digestive/alimentary_phenotyp1.10404897
47MP0005167_abnormal_blood-brain_barrier1.08962631
48MP0010329_abnormal_lipoprotein_level1.08713027
49MP0001664_abnormal_digestion1.07971369
50MP0001501_abnormal_sleep_pattern1.06414128
51MP0010155_abnormal_intestine_physiology1.06135971
52MP0001873_stomach_inflammation1.06089996
53MP0005448_abnormal_energy_balance1.02320149
54MP0003186_abnormal_redox_activity1.02206002
55MP0003283_abnormal_digestive_organ1.02100112
56MP0004270_analgesia1.01394546
57MP0003868_abnormal_feces_composition0.98544942
58MP0002118_abnormal_lipid_homeostasis0.96634106
59MP0000230_abnormal_systemic_arterial0.94949222
60MP0002971_abnormal_brown_adipose0.94067123
61MP0004782_abnormal_surfactant_physiolog0.92548107
62MP0002089_abnormal_postnatal_growth/wei0.92474347
63MP0005666_abnormal_adipose_tissue0.91404013
64MP0006036_abnormal_mitochondrial_physio0.90396041
65MP0004858_abnormal_nervous_system0.89388263
66MP0002396_abnormal_hematopoietic_system0.88321803
67MP0003705_abnormal_hypodermis_morpholog0.88157243
68MP0005501_abnormal_skin_physiology0.86958589
69MP0000477_abnormal_intestine_morphology0.85753946
70MP0001845_abnormal_inflammatory_respons0.84577735
71MP0000609_abnormal_liver_physiology0.84569649
72MP0006054_spinal_hemorrhage0.81241236
73MP0003183_abnormal_peptide_metabolism0.80216412
74MP0009115_abnormal_fat_cell0.78827932
75MP0002135_abnormal_kidney_morphology0.77677667
76MP0009785_altered_susceptibility_to0.77019739
77MP0002896_abnormal_bone_mineralization0.74863234
78MP0003724_increased_susceptibility_to0.74785048
79MP0001764_abnormal_homeostasis0.70469348
80MP0002166_altered_tumor_susceptibility0.70256984
81MP0009642_abnormal_blood_homeostasis0.69437848
82MP0000537_abnormal_urethra_morphology0.69363225
83MP0005535_abnormal_body_temperature0.67127126
84MP0000490_abnormal_crypts_of0.66956495
85MP0000465_gastrointestinal_hemorrhage0.65667939
86MP0003879_abnormal_hair_cell0.64076001
87MP0005310_abnormal_salivary_gland0.62678673
88MP0002168_other_aberrant_phenotype0.60869507
89MP0005670_abnormal_white_adipose0.59663580
90MP0000249_abnormal_blood_vessel0.58059624
91MP0005025_abnormal_response_to0.57716516
92MP0002098_abnormal_vibrissa_morphology0.56766101
93MP0005174_abnormal_tail_pigmentation0.54957157
94MP0006082_CNS_inflammation0.54630381
95MP0003941_abnormal_skin_development0.54547868
96MP0003303_peritoneal_inflammation0.53368963
97MP0005408_hypopigmentation0.53056979
98MP0001835_abnormal_antigen_presentation0.52886025
99MP0003638_abnormal_response/metabolism_0.52566356
100MP0009333_abnormal_splenocyte_physiolog0.52361383
101MP0004947_skin_inflammation0.52041531
102MP0004484_altered_response_of0.50039576
103MP0000747_muscle_weakness0.49833959
104MP0002006_tumorigenesis0.49572361
105MP0001661_extended_life_span0.49400366
106MP0002928_abnormal_bile_duct0.48933466
107MP0010352_gastrointestinal_tract_polyps0.48683305
108MP0006138_congestive_heart_failure0.48319992
109MP0005334_abnormal_fat_pad0.47554749
110MP0002009_preneoplasia0.47368162
111MP0008469_abnormal_protein_level0.47035176
112MP0009384_cardiac_valve_regurgitation0.46779982
113MP0003436_decreased_susceptibility_to0.46769701
114MP0000015_abnormal_ear_pigmentation0.46760571
115MP0002078_abnormal_glucose_homeostasis0.45861631
116MP0005166_decreased_susceptibility_to0.45118167
117MP0001849_ear_inflammation0.44299961
118MP0002148_abnormal_hypersensitivity_rea0.44055531
119MP0000598_abnormal_liver_morphology0.43659948
120MP0001485_abnormal_pinna_reflex0.43105934
121MP0000604_amyloidosis0.43095320
122MP0000566_synostosis0.42528808
123MP0010678_abnormal_skin_adnexa0.42146386
124MP0010386_abnormal_urinary_bladder0.41961668
125MP0000678_abnormal_parathyroid_gland0.41760117
126MP0001216_abnormal_epidermal_layer0.40760341
127MP0003315_abnormal_perineum_morphology0.39898432
128MP0009764_decreased_sensitivity_to0.39897955
129MP0005165_increased_susceptibility_to0.39533130
130MP0003329_amyloid_beta_deposits0.39072412
131MP0006035_abnormal_mitochondrial_morpho0.38596946
132MP0005395_other_phenotype0.38570731
133MP0003953_abnormal_hormone_level0.37620357
134MP0005375_adipose_tissue_phenotype0.37328149
135MP0000377_abnormal_hair_follicle0.37210386
136MP0008872_abnormal_physiological_respon0.36657502

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)7.08404160
2Hyperactive renin-angiotensin system (HP:0000841)6.76479490
3Increased circulating renin level (HP:0000848)6.71735024
4Gout (HP:0001997)6.21524289
5Hypomagnesemia (HP:0002917)6.21222198
6Hypokalemic alkalosis (HP:0001949)6.15976127
7Abnormality of chloride homeostasis (HP:0011422)6.05842683
8Abnormality of glutamine family amino acid metabolism (HP:0010902)5.76437764
9Abnormality of magnesium homeostasis (HP:0004921)5.54909616
10Hypobetalipoproteinemia (HP:0003563)5.45744019
11Polyuria (HP:0000103)5.39033908
12Abnormal urine output (HP:0012590)5.16388612
13Proximal tubulopathy (HP:0000114)5.10394565
14Abnormality of renal excretion (HP:0011036)5.01305255
15Hyperglycinuria (HP:0003108)5.00801601
16Increased purine levels (HP:0004368)4.71999231
17Hyperuricemia (HP:0002149)4.71999231
18Abnormality of renin-angiotensin system (HP:0000847)4.59858258
19Acanthocytosis (HP:0001927)4.59086510
20Tetany (HP:0001281)4.54622120
21Abnormality of purine metabolism (HP:0004352)4.50564226
22Alkalosis (HP:0001948)4.40419551
23Hyperaldosteronism (HP:0000859)4.35020282
24Abnormal drinking behavior (HP:0030082)4.19026006
25Polydipsia (HP:0001959)4.19026006
26Abnormality of vitamin metabolism (HP:0100508)4.02517135
27Abnormality of glycine metabolism (HP:0010895)3.99992200
28Abnormality of serine family amino acid metabolism (HP:0010894)3.99992200
29Renal salt wasting (HP:0000127)3.90778748
30Abnormality of proline metabolism (HP:0010907)3.76037560
31Hydroxyprolinuria (HP:0003080)3.76037560
32Generalized aminoaciduria (HP:0002909)3.73757255
33Pigmentary retinal degeneration (HP:0001146)3.71571455
34Hypercalciuria (HP:0002150)3.67458544
35Malnutrition (HP:0004395)3.58166019
36Glycosuria (HP:0003076)3.56486876
37Abnormality of urine glucose concentration (HP:0011016)3.56486876
38Ketoacidosis (HP:0001993)3.44885923
39Hypokalemia (HP:0002900)3.37136770
40Wide cranial sutures (HP:0010537)3.36103846
41Systemic lupus erythematosus (HP:0002725)3.31904980
42Abnormality of nucleobase metabolism (HP:0010932)3.26544379
43Ileus (HP:0002595)3.22890343
44Congenital sensorineural hearing impairment (HP:0008527)3.18388363
45Abnormality of aspartate family amino acid metabolism (HP:0010899)3.15694833
46Hyperphosphaturia (HP:0003109)3.10308475
47Nephrolithiasis (HP:0000787)3.08096742
48Renal tubular acidosis (HP:0001947)3.06918350
49Xanthomatosis (HP:0000991)3.03458835
50Delayed epiphyseal ossification (HP:0002663)3.01533978
51Megaloblastic anemia (HP:0001889)2.94646917
52Dehydration (HP:0001944)2.88735996
53Abnormal urine phosphate concentration (HP:0012599)2.88394672
54Ketosis (HP:0001946)2.86897386
55Steatorrhea (HP:0002570)2.84802414
56Abnormality of fatty-acid metabolism (HP:0004359)2.83916308
57Posterior subcapsular cataract (HP:0007787)2.82991991
58Abnormality of potassium homeostasis (HP:0011042)2.81247636
59Vacuolated lymphocytes (HP:0001922)2.76647774
60Hyperparathyroidism (HP:0000843)2.72841439
61Enlarged epiphyses (HP:0010580)2.69312428
62Hypolipoproteinemia (HP:0010981)2.67791593
63Hyperglycinemia (HP:0002154)2.64321363
64Abnormality of small intestinal villus morphology (HP:0011472)2.60884046
65Villous atrophy (HP:0011473)2.60884046
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56660395
67Dicarboxylic aciduria (HP:0003215)2.56660395
68Eczematoid dermatitis (HP:0000976)2.56350280
69Confusion (HP:0001289)2.55050939
70Vascular calcification (HP:0004934)2.54777422
71Abnormality of sulfur amino acid metabolism (HP:0004339)2.53957336
72Hypophosphatemia (HP:0002148)2.52926668
73Widely patent fontanelles and sutures (HP:0004492)2.52759252
74Hyperammonemia (HP:0001987)2.50210285
75Focal segmental glomerulosclerosis (HP:0000097)2.46560839
76Nephrocalcinosis (HP:0000121)2.44380658
77Hemorrhage of the eye (HP:0011885)2.40621097
78Hypotension (HP:0002615)2.40546388
79Rickets (HP:0002748)2.35695694
80Abnormal tarsal ossification (HP:0008369)2.33478057
81Abnormality of the vitamin B12 metabolism (HP:0004341)2.30574661
82Metabolic acidosis (HP:0001942)2.28945368
83Thin bony cortex (HP:0002753)2.26254216
84Cardiovascular calcification (HP:0011915)2.26018193
85Hyponatremia (HP:0002902)2.22162947
86Chronic diarrhea (HP:0002028)2.22053646
87Metaphyseal cupping (HP:0003021)2.21829175
88Fat malabsorption (HP:0002630)2.17144660
89Delayed CNS myelination (HP:0002188)2.16375063
90Vomiting (HP:0002013)2.16022836
91Abnormality of sodium homeostasis (HP:0010931)2.14862453
92Protuberant abdomen (HP:0001538)2.13798701
93Abnormality of vitamin B metabolism (HP:0004340)2.12393237
94Epidermoid cyst (HP:0200040)2.10454892
95Cerebral palsy (HP:0100021)2.08186139
96Adrenal overactivity (HP:0002717)2.07223014
97Decreased circulating renin level (HP:0003351)2.07087373
98Abnormal glucose tolerance (HP:0001952)2.05286131
99Intrahepatic cholestasis (HP:0001406)2.05191504
100Subcapsular cataract (HP:0000523)2.05180180
101Lethargy (HP:0001254)2.04667482
102Abnormal enzyme/coenzyme activity (HP:0012379)2.04159583
103Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03296658
104Nausea (HP:0002018)2.01121277
105Poikilocytosis (HP:0004447)2.00939225
106Hyperphosphatemia (HP:0002905)2.00632375
107Flat acetabular roof (HP:0003180)2.00349039
108Abnormality of alkaline phosphatase activity (HP:0004379)1.98631437
109Pancreatitis (HP:0001733)1.92830487
110Gastrointestinal dysmotility (HP:0002579)1.90629358
111Abnormality of renal resorption (HP:0011038)1.88804300
112Gingivitis (HP:0000230)1.88746752
113Growth hormone excess (HP:0000845)1.88165263
114Sensorimotor neuropathy (HP:0007141)1.86878557
115Methylmalonic aciduria (HP:0012120)1.86780191
116Abnormality of carpal bone ossification (HP:0006257)1.86726272
117Conjugated hyperbilirubinemia (HP:0002908)1.86392439
118Abnormality of the costochondral junction (HP:0000919)1.84843251
119Multiple lipomas (HP:0001012)1.83669387
120Right ventricular cardiomyopathy (HP:0011663)1.82606788
121Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82321532
122Glomerulosclerosis (HP:0000096)1.81933168
123Abnormal biliary tract morphology (HP:0012440)1.80957138
124Renal tubular dysfunction (HP:0000124)1.79908781
125Chondrocalcinosis (HP:0000934)1.76501420
126Enlarged kidneys (HP:0000105)1.76323400
127Metaphyseal irregularity (HP:0003025)1.76231125
128Potter facies (HP:0002009)1.74831978
129Facial shape deformation (HP:0011334)1.74831978
130Pili torti (HP:0003777)1.73880506
131Petechiae (HP:0000967)1.73375976
132Symptomatic seizures (HP:0011145)1.72471386
133Bilateral sensorineural hearing impairment (HP:0008619)1.72160233
134Late onset (HP:0003584)1.71303440
135Abdominal distention (HP:0003270)1.70658093
136Irritability (HP:0000737)1.68949950
137Abnormality of monocarboxylic acid metabolism (HP:0010996)1.68759934
138Hypocalcemia (HP:0002901)1.68250199
139Segmental peripheral demyelination/remyelination (HP:0003481)1.67458258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.74864117
2WNK47.33726792
3WNK36.32766231
4OXSR16.18575408
5FRK3.75598844
6MST1R3.65033411
7STK393.64521580
8MST43.24610415
9BCKDK2.11395399
10STK38L2.09983411
11PDK42.01984901
12PDK32.01984901
13LMTK22.00188314
14NEK11.81613808
15PDK21.63714615
16GRK61.61940677
17NME11.58981607
18MAP3K121.58973242
19MYLK1.50972715
20WNK11.50689446
21MAP2K21.46058208
22MAP3K21.44200023
23TYK21.42877328
24PIK3CA1.38918297
25EPHA31.30721685
26STK241.30342111
27TNIK1.29891271
28RIPK11.29588600
29PTK61.27714676
30SGK2231.22069555
31SGK4941.22069555
32MET1.21717587
33PRKG21.18420440
34MAP4K11.15992995
35EPHA41.14222895
36PRPF4B1.06567949
37LRRK21.02727322
38TESK10.93679488
39BMPR20.92958113
40PTK20.89072891
41MAP3K70.88205305
42EPHB10.87649988
43PAK40.87483670
44KSR20.86527202
45ERN10.83380595
46FGFR30.83149514
47PRKCI0.79830662
48STK380.79275209
49LATS10.76693368
50SGK30.75601067
51NLK0.75183637
52EPHB20.73859003
53AKT30.73256297
54STK100.71406670
55FER0.70884317
56MAPK110.69890392
57CDC42BPA0.68815255
58GSK3A0.68499209
59PRKAA10.67337894
60PRKAA20.66479433
61FGFR40.66416366
62MAP2K10.63592556
63EPHA20.57595904
64TTK0.56902997
65PAK30.56802020
66MAP3K30.56322384
67PDPK10.54602875
68SGK20.49354312
69IRAK10.48317735
70PINK10.48209598
71DYRK1B0.47655528
72CASK0.47010433
73YES10.45433592
74TBK10.43897203
75FYN0.41064455
76RET0.40610979
77ABL20.39835728
78MAP3K100.39274499
79TAOK10.38564530
80ERBB20.38478407
81JAK10.37144535
82CSF1R0.36658346
83ZAP700.36305524
84DDR20.35979054
85PDK10.35727233
86MAP3K80.35619480
87SYK0.34957644
88SGK10.34830952
89BTK0.34656521
90GRK10.33271343
91TEC0.32640499
92STK30.32513326
93CDK190.31784001
94NEK60.31492262
95STK110.30543404
96BMX0.30140474
97PDGFRA0.29569609
98IKBKE0.27483949
99MELK0.26740996
100CDK60.26155178
101PRKCZ0.25719127
102LYN0.25242003
103PRKCA0.24985473
104DAPK20.24735441
105ITK0.24472468
106PRKCD0.23577724
107LIMK10.22780571
108PRKACG0.22523221
109MAPKAPK20.22379663
110SCYL20.21718179
111ROCK10.20575228
112MATK0.20339718
113AKT20.19776781
114MAP3K140.19673545
115RPS6KA20.19057282
116PRKCQ0.18062645
117CAMK2G0.17920234
118IGF1R0.17516506
119LCK0.17354058
120INSRR0.17165831
121TRIB30.17153190
122PRKACA0.16778434
123CAMK2D0.16052159
124ERBB40.15736668
125NUAK10.14843457
126PIM10.14596355
127TESK20.14271616
128IRAK40.13842125
129TGFBR20.13265247
130MAP2K60.12615506
131SRC0.12272134
132MAP3K10.11679618
133NME20.11671858
134RIPK40.10863213
135MAP3K110.10440970
136CSNK1A10.10168001
137PTK2B0.10092060
138JAK20.08801212
139TIE10.08235633
140CAMK2B0.07574001
141CSK0.07203106

Predicted pathways (KEGG)

RankGene SetZ-score
1AMPK signaling pathway_Homo sapiens_hsa041524.98859238
2Butanoate metabolism_Homo sapiens_hsa006503.40227140
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33182356
4Sulfur metabolism_Homo sapiens_hsa009203.21747436
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.20641155
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.16125958
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.11627373
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.78552161
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.77597289
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67391266
11Propanoate metabolism_Homo sapiens_hsa006402.58020121
12Mineral absorption_Homo sapiens_hsa049782.49858213
13Bile secretion_Homo sapiens_hsa049762.46835041
14Vitamin digestion and absorption_Homo sapiens_hsa049772.39310447
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28289278
16Tryptophan metabolism_Homo sapiens_hsa003802.24673858
17Fatty acid degradation_Homo sapiens_hsa000712.23163653
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.19000958
19Pyruvate metabolism_Homo sapiens_hsa006202.12526243
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.03380207
21Peroxisome_Homo sapiens_hsa041461.99694224
22Renin-angiotensin system_Homo sapiens_hsa046141.92749713
23Linoleic acid metabolism_Homo sapiens_hsa005911.89588653
24Protein digestion and absorption_Homo sapiens_hsa049741.78277890
25beta-Alanine metabolism_Homo sapiens_hsa004101.77590916
26Histidine metabolism_Homo sapiens_hsa003401.76565700
27Glutathione metabolism_Homo sapiens_hsa004801.67292422
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61660681
29PPAR signaling pathway_Homo sapiens_hsa033201.58321214
30Carbon metabolism_Homo sapiens_hsa012001.51278204
31Arginine and proline metabolism_Homo sapiens_hsa003301.50715169
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48723527
33Fatty acid metabolism_Homo sapiens_hsa012121.47240173
34Collecting duct acid secretion_Homo sapiens_hsa049661.45418896
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42815124
36Starch and sucrose metabolism_Homo sapiens_hsa005001.37674793
37Fructose and mannose metabolism_Homo sapiens_hsa000511.36964927
38Fat digestion and absorption_Homo sapiens_hsa049751.30282366
39Glycerolipid metabolism_Homo sapiens_hsa005611.26497997
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20055723
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14822434
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11848435
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10610769
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09214692
45Other glycan degradation_Homo sapiens_hsa005111.07093660
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00549451
47Arginine biosynthesis_Homo sapiens_hsa002200.99933698
48Folate biosynthesis_Homo sapiens_hsa007900.98066410
49Ether lipid metabolism_Homo sapiens_hsa005650.95420900
50Lysine degradation_Homo sapiens_hsa003100.94053211
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93047573
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.90924099
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.90553981
54Asthma_Homo sapiens_hsa053100.89500603
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88559046
56Selenocompound metabolism_Homo sapiens_hsa004500.88111707
57Phenylalanine metabolism_Homo sapiens_hsa003600.85709113
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.79664257
59Pentose phosphate pathway_Homo sapiens_hsa000300.74078981
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73807515
61Thyroid hormone synthesis_Homo sapiens_hsa049180.72586012
62Biosynthesis of amino acids_Homo sapiens_hsa012300.70785320
63Nitrogen metabolism_Homo sapiens_hsa009100.69947401
64Galactose metabolism_Homo sapiens_hsa000520.69395574
65Allograft rejection_Homo sapiens_hsa053300.67757286
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66130229
67Autoimmune thyroid disease_Homo sapiens_hsa053200.62497599
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.61999391
69Graft-versus-host disease_Homo sapiens_hsa053320.58833878
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.55510598
71Metabolic pathways_Homo sapiens_hsa011000.53584378
72Gastric acid secretion_Homo sapiens_hsa049710.49921605
73Oxidative phosphorylation_Homo sapiens_hsa001900.47932341
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.47702513
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47619581
76Fatty acid elongation_Homo sapiens_hsa000620.45470672
77Chemical carcinogenesis_Homo sapiens_hsa052040.43842524
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43025810
79Type I diabetes mellitus_Homo sapiens_hsa049400.41920489
80Staphylococcus aureus infection_Homo sapiens_hsa051500.41423436
81Sphingolipid metabolism_Homo sapiens_hsa006000.40902720
82Vibrio cholerae infection_Homo sapiens_hsa051100.40827934
83Renin secretion_Homo sapiens_hsa049240.40707050
84ABC transporters_Homo sapiens_hsa020100.39915650
85Arachidonic acid metabolism_Homo sapiens_hsa005900.39024316
86Caffeine metabolism_Homo sapiens_hsa002320.37100027
87Fatty acid biosynthesis_Homo sapiens_hsa000610.36699418
88Retinol metabolism_Homo sapiens_hsa008300.34263601
89Tight junction_Homo sapiens_hsa045300.33924280
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33203202
91Lysosome_Homo sapiens_hsa041420.31670249
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.31391131
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29541795
94Choline metabolism in cancer_Homo sapiens_hsa052310.25060857
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24972364
96Parkinsons disease_Homo sapiens_hsa050120.24272449
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23736887
98Steroid biosynthesis_Homo sapiens_hsa001000.23445682
99Antigen processing and presentation_Homo sapiens_hsa046120.23018885
100Cocaine addiction_Homo sapiens_hsa050300.20620910
101Sulfur relay system_Homo sapiens_hsa041220.19175768
102Inositol phosphate metabolism_Homo sapiens_hsa005620.18338977
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17928206
104Pancreatic secretion_Homo sapiens_hsa049720.17539386
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.16317556
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.15574239
107Leishmaniasis_Homo sapiens_hsa051400.15429329
108Glucagon signaling pathway_Homo sapiens_hsa049220.14856894
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13777406
110Tyrosine metabolism_Homo sapiens_hsa003500.12992723
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.12933369
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10542534
113Serotonergic synapse_Homo sapiens_hsa047260.09814557
114Hepatitis C_Homo sapiens_hsa051600.09613527
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09485603
116Insulin secretion_Homo sapiens_hsa049110.08957896
117Bladder cancer_Homo sapiens_hsa052190.08286787
118Amphetamine addiction_Homo sapiens_hsa050310.07522378
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06924756
120Alzheimers disease_Homo sapiens_hsa050100.06625170
121Insulin resistance_Homo sapiens_hsa049310.06473510
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.05449343
123Hematopoietic cell lineage_Homo sapiens_hsa046400.05302183
124Viral myocarditis_Homo sapiens_hsa054160.04734942
125GnRH signaling pathway_Homo sapiens_hsa049120.02750690
126Cardiac muscle contraction_Homo sapiens_hsa042600.02748041
127African trypanosomiasis_Homo sapiens_hsa051430.00478848
128Pertussis_Homo sapiens_hsa051330.00282028
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.00157313

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