TMLHE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded protein converts trimethyllysine into hydroxytrimethyllysine. A pseudogene of this gene is found on chromosome X. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)6.07867332
2actin-myosin filament sliding (GO:0033275)6.07867332
3regulation of relaxation of muscle (GO:1901077)5.59047776
4actin-mediated cell contraction (GO:0070252)5.36567743
5purine nucleotide salvage (GO:0032261)5.10414937
6adenosine metabolic process (GO:0046085)4.95351208
7polyketide metabolic process (GO:0030638)4.84270244
8doxorubicin metabolic process (GO:0044598)4.84270244
9daunorubicin metabolic process (GO:0044597)4.84270244
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.54603451
11tryptophan catabolic process (GO:0006569)4.51070124
12indole-containing compound catabolic process (GO:0042436)4.51070124
13indolalkylamine catabolic process (GO:0046218)4.51070124
14regulation of skeletal muscle contraction (GO:0014819)4.40164663
15sarcoplasmic reticulum calcium ion transport (GO:0070296)4.39433137
16amine catabolic process (GO:0009310)4.32911390
17cellular biogenic amine catabolic process (GO:0042402)4.32911390
18cell wall macromolecule metabolic process (GO:0044036)4.29332828
19tryptophan metabolic process (GO:0006568)4.29039418
20skeletal muscle contraction (GO:0003009)4.15717268
21regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.02490692
22aromatic amino acid family catabolic process (GO:0009074)3.96746175
23purine-containing compound salvage (GO:0043101)3.95637169
24oxidative phosphorylation (GO:0006119)3.90482941
25fatty acid transmembrane transport (GO:1902001)3.82259979
26actin filament-based movement (GO:0030048)3.80765251
27detection of molecule of bacterial origin (GO:0032490)3.75996860
28myofibril assembly (GO:0030239)3.66155727
29ether lipid metabolic process (GO:0046485)3.65891160
30NADH metabolic process (GO:0006734)3.59422212
31production of molecular mediator involved in inflammatory response (GO:0002532)3.58762345
32indolalkylamine metabolic process (GO:0006586)3.52844223
33creatine metabolic process (GO:0006600)3.50333753
34striated muscle contraction (GO:0006941)3.47737262
35tricarboxylic acid cycle (GO:0006099)3.47164119
36cellular hyperosmotic response (GO:0071474)3.46347348
37aminoglycoside antibiotic metabolic process (GO:0030647)3.44246778
38inner mitochondrial membrane organization (GO:0007007)3.42149355
39immunoglobulin mediated immune response (GO:0016064)3.38659336
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.37422983
41carnitine shuttle (GO:0006853)3.36598261
42interkinetic nuclear migration (GO:0022027)3.36185057
43sarcomere organization (GO:0045214)3.35236070
44negative regulation of mast cell activation (GO:0033004)3.35124440
45kynurenine metabolic process (GO:0070189)3.35077211
46polysaccharide catabolic process (GO:0000272)3.34988639
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.32735379
48L-phenylalanine catabolic process (GO:0006559)3.32735379
49positive regulation of cellular amide metabolic process (GO:0034250)3.31539286
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.29349686
51positive regulation of B cell differentiation (GO:0045579)3.26650498
52toxin transport (GO:1901998)3.20905466
53regulation of sequestering of triglyceride (GO:0010889)3.19947287
54response to hydroperoxide (GO:0033194)3.19410024
55glucan biosynthetic process (GO:0009250)3.16295990
56glycogen biosynthetic process (GO:0005978)3.16295990
57regulation of B cell receptor signaling pathway (GO:0050855)3.14607171
58valine metabolic process (GO:0006573)3.13934132
59positive regulation of chemokine secretion (GO:0090197)3.13909673
60hepatocyte apoptotic process (GO:0097284)3.12878798
61regulation of B cell apoptotic process (GO:0002902)3.11316190
62glucosamine-containing compound catabolic process (GO:1901072)3.10085616
63homocysteine metabolic process (GO:0050667)3.08442344
64positive regulation of macrophage cytokine production (GO:0060907)3.07047990
65high-density lipoprotein particle remodeling (GO:0034375)3.05881608
66triglyceride homeostasis (GO:0070328)3.02544684
67acylglycerol homeostasis (GO:0055090)3.02544684
68ubiquinone biosynthetic process (GO:0006744)3.02442986
69AMP metabolic process (GO:0046033)3.01339216
70superoxide anion generation (GO:0042554)3.00062798
71negative regulation of lipase activity (GO:0060192)2.98874648
72NAD biosynthetic process (GO:0009435)2.98185490
73ubiquinone metabolic process (GO:0006743)2.95523108
74nucleotide transmembrane transport (GO:1901679)2.94149924
75response to muscle activity (GO:0014850)2.94069478
76response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.93932909
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.93507707
78L-phenylalanine metabolic process (GO:0006558)2.93507707
79regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.93258852
80regulation of actin filament-based movement (GO:1903115)2.92909772
81negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.92031566
82mesenchymal cell differentiation involved in renal system development (GO:2001012)2.92013406
83mesenchymal cell differentiation involved in kidney development (GO:0072161)2.92013406
84histone mRNA catabolic process (GO:0071044)2.91549432
85glyoxylate metabolic process (GO:0046487)2.89583095
86cardiac muscle contraction (GO:0060048)2.89178841
87cardiac muscle hypertrophy (GO:0003300)2.85829012
88cardiac myofibril assembly (GO:0055003)2.85363875
89reverse cholesterol transport (GO:0043691)2.85253471
90detection of external biotic stimulus (GO:0098581)2.84272387
91protein carboxylation (GO:0018214)2.81946849
92peptidyl-glutamic acid carboxylation (GO:0017187)2.81946849
93aromatic amino acid family metabolic process (GO:0009072)2.81223640
94regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.81171141
95phospholipid efflux (GO:0033700)2.78946276
96carnitine transmembrane transport (GO:1902603)2.77557904
97protein-lipid complex remodeling (GO:0034368)2.75083023
98macromolecular complex remodeling (GO:0034367)2.75083023
99plasma lipoprotein particle remodeling (GO:0034369)2.75083023
100very-low-density lipoprotein particle assembly (GO:0034379)2.74621686
101amino-acid betaine transport (GO:0015838)2.73377627
102carnitine transport (GO:0015879)2.73377627
103regulation of triglyceride catabolic process (GO:0010896)2.73327966
104mRNA modification (GO:0016556)2.72390435
105positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.71806047
106cellular glucuronidation (GO:0052695)2.71451370
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.71209030
108striated muscle hypertrophy (GO:0014897)2.71193474
109urea cycle (GO:0000050)2.71181482
110urea metabolic process (GO:0019627)2.71181482
111cellular anion homeostasis (GO:0030002)2.70909267
112negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.69340991
113omega-hydroxylase P450 pathway (GO:0097267)2.68519603
114chaperone mediated protein folding requiring cofactor (GO:0051085)2.68483283
115cholesterol efflux (GO:0033344)2.67927380
116aggressive behavior (GO:0002118)2.67478117
117growth hormone receptor signaling pathway (GO:0060396)2.66760070
118coenzyme catabolic process (GO:0009109)2.66516451
119regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65882318
120response to inactivity (GO:0014854)2.63403893
121glucan catabolic process (GO:0009251)2.63342269
122regulation of cholesterol esterification (GO:0010872)2.62927808
123purine ribonucleotide transport (GO:0015868)2.62808644
124auditory receptor cell stereocilium organization (GO:0060088)2.62239833
125regulation of macrophage cytokine production (GO:0010935)2.62085982
126aspartate family amino acid catabolic process (GO:0009068)2.61860179
127sulfate transmembrane transport (GO:1902358)2.60866576
128glycogen catabolic process (GO:0005980)2.60497606
129B cell mediated immunity (GO:0019724)2.60261651
130regulation of chemokine secretion (GO:0090196)2.59865724
131prostate gland growth (GO:0060736)2.59809882
132complement activation, alternative pathway (GO:0006957)2.59025868
133phospholipid homeostasis (GO:0055091)2.58896399
134response to epinephrine (GO:0071871)2.58889913
135tyrosine metabolic process (GO:0006570)2.58262375
136cellular polysaccharide catabolic process (GO:0044247)2.57667182
137oxaloacetate metabolic process (GO:0006107)2.57320532
138peroxisome fission (GO:0016559)2.56396448
139negative regulation of B cell proliferation (GO:0030889)2.56319272
140GPI anchor biosynthetic process (GO:0006506)2.56276640
141bile acid biosynthetic process (GO:0006699)2.56201476
142cellular response to epinephrine stimulus (GO:0071872)2.56082486
143uronic acid metabolic process (GO:0006063)2.55747347
144glucuronate metabolic process (GO:0019585)2.55747347
145bile acid metabolic process (GO:0008206)2.55307534
146nicotinamide nucleotide biosynthetic process (GO:0019359)2.54932413
147pyridine nucleotide biosynthetic process (GO:0019363)2.54932413
148regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.54034427
149drug catabolic process (GO:0042737)2.53690868
150phagocytosis, recognition (GO:0006910)2.53339190
151muscle hypertrophy (GO:0014896)2.53215487
152skeletal muscle adaptation (GO:0043501)2.53061381
153androgen metabolic process (GO:0008209)2.52545704
154microglial cell activation (GO:0001774)2.52487713
155detection of biotic stimulus (GO:0009595)2.52134820
156regulation of sarcomere organization (GO:0060297)2.51799110
157adult heart development (GO:0007512)2.50874236
158energy homeostasis (GO:0097009)2.50486167
159response to host immune response (GO:0052572)2.50362857
160response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.50362857
161bile acid and bile salt transport (GO:0015721)2.50255861
162positive thymic T cell selection (GO:0045059)2.50156505
163extracellular negative regulation of signal transduction (GO:1900116)2.49815157
164extracellular regulation of signal transduction (GO:1900115)2.49815157
165cellular response to growth hormone stimulus (GO:0071378)2.49698084
166inner ear receptor stereocilium organization (GO:0060122)2.49553896
167proteasome assembly (GO:0043248)2.49512932
168polyol transport (GO:0015791)2.48513611
169regulation of activation of Janus kinase activity (GO:0010533)2.47928183
170purine nucleotide transport (GO:0015865)2.46120458
171DNA demethylation (GO:0080111)2.45194889
172opsonization (GO:0008228)2.43253523
173negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.43029091
174trivalent inorganic anion homeostasis (GO:0072506)2.42715480
175phosphate ion homeostasis (GO:0055062)2.42715480
176branched-chain amino acid catabolic process (GO:0009083)2.41539254
177low-density lipoprotein particle remodeling (GO:0034374)2.41170751
178fatty acid beta-oxidation (GO:0006635)2.40929804
179nitrogen cycle metabolic process (GO:0071941)2.40087464
180adenine nucleotide transport (GO:0051503)2.37375167
181lipid oxidation (GO:0034440)2.36887271
182fatty acid oxidation (GO:0019395)2.36848648
183biotin metabolic process (GO:0006768)2.36117016
184cell differentiation involved in metanephros development (GO:0072202)2.34190465
185plasma lipoprotein particle organization (GO:0071827)2.32749703
186branched-chain amino acid metabolic process (GO:0009081)2.31748918
187plasma lipoprotein particle clearance (GO:0034381)2.30476866
188regulation of protein activation cascade (GO:2000257)2.30188674
189alpha-amino acid catabolic process (GO:1901606)2.29448552
190exogenous drug catabolic process (GO:0042738)2.29354684
191linoleic acid metabolic process (GO:0043651)2.29253989
192regulation of bile acid biosynthetic process (GO:0070857)2.27944232
193nucleotide transport (GO:0006862)2.27623743
194positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.25158324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.80471373
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.24722211
3GATA1_22025678_ChIP-Seq_K562_Human2.98071680
4EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56729711
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.39718920
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34480048
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33226689
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32266020
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.28907412
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26236459
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26038593
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13524318
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.12611989
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.04813075
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01094583
16ELK1_19687146_ChIP-ChIP_HELA_Human2.00632850
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99632054
18RXR_22158963_ChIP-Seq_LIVER_Mouse1.91462391
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.91206065
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90568969
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87647886
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86963552
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86645002
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.85694111
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85515503
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.85242453
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84129894
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.83748859
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.80764704
30EWS_26573619_Chip-Seq_HEK293_Human1.80615477
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80530754
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77434262
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.76764246
34TAF15_26573619_Chip-Seq_HEK293_Human1.75977330
35P300_19829295_ChIP-Seq_ESCs_Human1.75408039
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.74281875
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.72627460
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70583376
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68224409
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.65040237
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.64476514
42FUS_26573619_Chip-Seq_HEK293_Human1.64220634
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63413408
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.62650029
45VDR_23849224_ChIP-Seq_CD4+_Human1.61654962
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58869734
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58197503
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.58120883
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56231184
50SALL4_22934838_ChIP-ChIP_CD34+_Human1.55359355
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54953331
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54395517
53P53_22387025_ChIP-Seq_ESCs_Mouse1.53647858
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.52674877
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.50852648
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49598462
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.49119915
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45044277
59CIITA_25753668_ChIP-Seq_RAJI_Human1.44540316
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43441603
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.43069612
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41765005
63EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40725772
64RUNX1_27457419_Chip-Seq_LIVER_Mouse1.40290763
65SMAD4_21799915_ChIP-Seq_A2780_Human1.40251698
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39191728
67SPI1_23547873_ChIP-Seq_NB4_Human1.38317248
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.37371135
69TP53_18474530_ChIP-ChIP_U2OS_Human1.36476493
70AR_21572438_ChIP-Seq_LNCaP_Human1.36255591
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35532841
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35345549
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.34960759
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34608125
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34573931
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33730562
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33544361
78P300_18555785_Chip-Seq_ESCs_Mouse1.33502896
79OCT4_18555785_Chip-Seq_ESCs_Mouse1.33262660
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33227682
81NMYC_18555785_Chip-Seq_ESCs_Mouse1.33147241
82PU1_27457419_Chip-Seq_LIVER_Mouse1.31806927
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.31083138
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30875220
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30729685
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30083684
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29640062
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29062590
89SOX2_18555785_Chip-Seq_ESCs_Mouse1.29017968
90VDR_22108803_ChIP-Seq_LS180_Human1.27525923
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27397907
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27325086
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.26026880
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25822290
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25770314
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25710951
97ZFX_18555785_Chip-Seq_ESCs_Mouse1.25287086
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25147042
99IGF1R_20145208_ChIP-Seq_DFB_Human1.24855996
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24527514
101IRF1_19129219_ChIP-ChIP_H3396_Human1.23471751
102ER_23166858_ChIP-Seq_MCF-7_Human1.23458344
103IRF8_27001747_Chip-Seq_BMDM_Mouse1.23122841
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21773890
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21545018
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21545018
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21381205
108GATA3_26560356_Chip-Seq_TH2_Human1.21285458
109JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20962299
110SMAD1_18555785_Chip-Seq_ESCs_Mouse1.20945112
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20600545
112CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19424063
113SOX2_19829295_ChIP-Seq_ESCs_Human1.19164070
114NANOG_19829295_ChIP-Seq_ESCs_Human1.19164070
115ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18968816
116STAT3_23295773_ChIP-Seq_U87_Human1.18719919
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.18466995
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18073632
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16860580
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16572204
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16354136
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16147869
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15955072
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15697270
125EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14347396
126RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14347396
127EZH2_22144423_ChIP-Seq_EOC_Human1.14042522
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13950206
129GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12940459
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.12841796
131BCAT_22108803_ChIP-Seq_LS180_Human1.12797896
132RUNX2_22187159_ChIP-Seq_PCA_Human1.12634206
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12559863
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12412978
135TP53_22573176_ChIP-Seq_HFKS_Human1.12328582
136KLF4_18555785_Chip-Seq_ESCs_Mouse1.12221467
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11480171
138FOXP3_21729870_ChIP-Seq_TREG_Human1.10868307
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10167455
140AR_25329375_ChIP-Seq_VCAP_Human1.10112262
141CTCF_18555785_Chip-Seq_ESCs_Mouse1.09827109
142CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09770117
143KDM2B_26808549_Chip-Seq_REH_Human1.09371588
144HTT_18923047_ChIP-ChIP_STHdh_Human1.06884991
145SCL_19346495_ChIP-Seq_HPC-7_Human1.06549557
146MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06516501
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04909677
148STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04204650
149IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03094833
150CBP_20019798_ChIP-Seq_JUKART_Human1.03094833
151SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03067549
152NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99784119
153FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99024277
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98864689
155CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97844072
156RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96353123
157AR_20517297_ChIP-Seq_VCAP_Human0.96176231
158MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95667930
159YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95414704
160FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94680246
161CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94023128
162MYB_26560356_Chip-Seq_TH2_Human0.93842473
163ESR1_20079471_ChIP-ChIP_T-47D_Human0.93490471
164PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93476586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.41418979
2MP0002139_abnormal_hepatobiliary_system4.43109791
3MP0005360_urolithiasis4.26345479
4MP0005365_abnormal_bile_salt3.94060669
5MP0000566_synostosis3.90692213
6MP0005670_abnormal_white_adipose3.81930997
7MP0005085_abnormal_gallbladder_physiolo3.79492904
8MP0004084_abnormal_cardiac_muscle3.68408465
9MP0003646_muscle_fatigue3.57792867
10MP0009697_abnormal_copulation3.48383433
11MP0003806_abnormal_nucleotide_metabolis3.21648256
12MP0004036_abnormal_muscle_relaxation3.06404913
13MP0004147_increased_porphyrin_level3.01150458
14MP0003252_abnormal_bile_duct2.98570213
15MP0004145_abnormal_muscle_electrophysio2.88959840
16MP0000749_muscle_degeneration2.83680308
17MP0005451_abnormal_body_composition2.59394325
18MP0004019_abnormal_vitamin_homeostasis2.47439014
19MP0008875_abnormal_xenobiotic_pharmacok2.46496686
20MP0002837_dystrophic_cardiac_calcinosis2.42818008
21MP0010329_abnormal_lipoprotein_level2.36702336
22MP0003195_calcinosis2.30338555
23MP0005646_abnormal_pituitary_gland2.13776785
24MP0004484_altered_response_of2.08642541
25MP0005645_abnormal_hypothalamus_physiol2.05981076
26MP0006054_spinal_hemorrhage2.04145668
27MP0002876_abnormal_thyroid_physiology1.99279189
28MP0000751_myopathy1.97862044
29MP0002102_abnormal_ear_morphology1.88428571
30MP0004215_abnormal_myocardial_fiber1.87790378
31MP0006036_abnormal_mitochondrial_physio1.86559318
32MP0004381_abnormal_hair_follicle1.84724521
33MP0006292_abnormal_olfactory_placode1.83789656
34MP0005171_absent_coat_pigmentation1.79831744
35MP0002332_abnormal_exercise_endurance1.75476478
36MP0005620_abnormal_muscle_contractility1.74766593
37MP0002106_abnormal_muscle_physiology1.73456228
38MP0005266_abnormal_metabolism1.68931280
39MP0005332_abnormal_amino_acid1.66417150
40MP0001835_abnormal_antigen_presentation1.63807669
41MP0002972_abnormal_cardiac_muscle1.63049319
42MP0003136_yellow_coat_color1.61873574
43MP0009764_decreased_sensitivity_to1.61583212
44MP0005330_cardiomyopathy1.60060211
45MP0004087_abnormal_muscle_fiber1.58931972
46MP0008995_early_reproductive_senescence1.56779141
47MP0002269_muscular_atrophy1.55950296
48MP0001188_hyperpigmentation1.48114770
49MP0008004_abnormal_stomach_pH1.47281855
50MP0004782_abnormal_surfactant_physiolog1.46974067
51MP0003941_abnormal_skin_development1.46604682
52MP0003656_abnormal_erythrocyte_physiolo1.46516567
53MP0001986_abnormal_taste_sensitivity1.46071492
54MP0001666_abnormal_nutrient_absorption1.45758011
55MP0005647_abnormal_sex_gland1.41816014
56MP0008775_abnormal_heart_ventricle1.41423506
57MP0003724_increased_susceptibility_to1.41207504
58MP0005248_abnormal_Harderian_gland1.41048297
59MP0005671_abnormal_response_to1.39801885
60MP0002138_abnormal_hepatobiliary_system1.39718229
61MP0003183_abnormal_peptide_metabolism1.38386730
62MP0005369_muscle_phenotype1.36198397
63MP0000759_abnormal_skeletal_muscle1.36101588
64MP0002118_abnormal_lipid_homeostasis1.35900030
65MP0008057_abnormal_DNA_replication1.32813704
66MP0005503_abnormal_tendon_morphology1.29730141
67MP0002277_abnormal_respiratory_mucosa1.28523815
68MP0004742_abnormal_vestibular_system1.27580927
69MP0001764_abnormal_homeostasis1.27384077
70MP0000747_muscle_weakness1.27249631
71MP0002166_altered_tumor_susceptibility1.27247882
72MP0003868_abnormal_feces_composition1.27032644
73MP0005551_abnormal_eye_electrophysiolog1.24806880
74MP0004233_abnormal_muscle_weight1.24236133
75MP0002127_abnormal_cardiovascular_syste1.24083441
76MP0001545_abnormal_hematopoietic_system1.22422223
77MP0005397_hematopoietic_system_phenotyp1.22422223
78MP0004883_abnormal_blood_vessel1.21817936
79MP0005409_darkened_coat_color1.20784570
80MP0002132_abnormal_respiratory_system1.18954298
81MP0001544_abnormal_cardiovascular_syste1.18894750
82MP0005385_cardiovascular_system_phenoty1.18894750
83MP0005464_abnormal_platelet_physiology1.18467353
84MP0010630_abnormal_cardiac_muscle1.18221876
85MP0003011_delayed_dark_adaptation1.17848932
86MP0010386_abnormal_urinary_bladder1.16217815
87MP0001800_abnormal_humoral_immune1.15558316
88MP0003221_abnormal_cardiomyocyte_apopto1.12919519
89MP0002249_abnormal_larynx_morphology1.12510960
90MP0005376_homeostasis/metabolism_phenot1.11576427
91MP0008058_abnormal_DNA_repair1.11050589
92MP0006035_abnormal_mitochondrial_morpho1.06267055
93MP0001324_abnormal_eye_pigmentation1.04915352
94MP0009384_cardiac_valve_regurgitation1.03348786
95MP0000372_irregular_coat_pigmentation1.02697153
96MP0005379_endocrine/exocrine_gland_phen1.00527025
97MP0005187_abnormal_penis_morphology1.00223259
98MP0002998_abnormal_bone_remodeling0.98650368
99MP0003950_abnormal_plasma_membrane0.98253984
100MP0000026_abnormal_inner_ear0.97739731
101MP0000427_abnormal_hair_cycle0.95912888
102MP0005334_abnormal_fat_pad0.95399357
103MP0000609_abnormal_liver_physiology0.94475310
104MP0005377_hearing/vestibular/ear_phenot0.93820799
105MP0003878_abnormal_ear_physiology0.93820799
106MP0005257_abnormal_intraocular_pressure0.93561389
107MP0003045_fibrosis0.93174133
108MP0002938_white_spotting0.91971307
109MP0005167_abnormal_blood-brain_barrier0.89252220
110MP0002928_abnormal_bile_duct0.88573850
111MP0005666_abnormal_adipose_tissue0.87921250
112MP0006276_abnormal_autonomic_nervous0.87754708
113MP0000516_abnormal_urinary_system0.86465211
114MP0005367_renal/urinary_system_phenotyp0.86465211
115MP0008438_abnormal_cutaneous_collagen0.85531005
116MP0006138_congestive_heart_failure0.85470339
117MP0001661_extended_life_span0.84984058
118MP0005174_abnormal_tail_pigmentation0.84438581
119MP0005075_abnormal_melanosome_morpholog0.84364310
120MP0002452_abnormal_antigen_presenting0.83356172
121MP0002098_abnormal_vibrissa_morphology0.82743035
122MP0001502_abnormal_circadian_rhythm0.82618104
123MP0004130_abnormal_muscle_cell0.82188779
124MP0003186_abnormal_redox_activity0.81976366
125MP0005319_abnormal_enzyme/_coenzyme0.81617859
126MP0002971_abnormal_brown_adipose0.81011034
127MP0000383_abnormal_hair_follicle0.80678723
128MP0002419_abnormal_innate_immunity0.79771680
129MP0002723_abnormal_immune_serum0.79442522
130MP0005084_abnormal_gallbladder_morpholo0.78492613
131MP0000049_abnormal_middle_ear0.78390860
132MP0010234_abnormal_vibrissa_follicle0.78029708
133MP0002638_abnormal_pupillary_reflex0.77479719
134MP0001346_abnormal_lacrimal_gland0.77304310
135MP0009115_abnormal_fat_cell0.76417909
136MP0000538_abnormal_urinary_bladder0.76316115
137MP0002168_other_aberrant_phenotype0.75859672
138MP0008007_abnormal_cellular_replicative0.75707832
139MP0010352_gastrointestinal_tract_polyps0.75443010
140MP0000733_abnormal_muscle_development0.74173018
141MP0003828_pulmonary_edema0.73660808
142MP0010307_abnormal_tumor_latency0.73624383
143MP0005253_abnormal_eye_physiology0.72713733
144MP0003690_abnormal_glial_cell0.71792279
145MP0009763_increased_sensitivity_to0.70713717
146MP0000750_abnormal_muscle_regeneration0.70041454
147MP0009785_altered_susceptibility_to0.69616428
148MP0000015_abnormal_ear_pigmentation0.69481921
149MP0005083_abnormal_biliary_tract0.69330717
150MP0005508_abnormal_skeleton_morphology0.67301335
151MP0001790_abnormal_immune_system0.67177672
152MP0005387_immune_system_phenotype0.67177672
153MP0005584_abnormal_enzyme/coenzyme_acti0.66832403
154MP0000689_abnormal_spleen_morphology0.66621057
155MP0002148_abnormal_hypersensitivity_rea0.65940667
156MP0000163_abnormal_cartilage_morphology0.65933321
157MP0003191_abnormal_cellular_cholesterol0.64591940
158MP0000013_abnormal_adipose_tissue0.64187316
159MP0002060_abnormal_skin_morphology0.64027804
160MP0008469_abnormal_protein_level0.63845104
161MP0005000_abnormal_immune_tolerance0.63096851
162MP0003787_abnormal_imprinting0.63048258
163MP0009643_abnormal_urine_homeostasis0.62871897
164MP0001186_pigmentation_phenotype0.62839921
165MP0008260_abnormal_autophagy0.59645950
166MP0002108_abnormal_muscle_morphology0.58757757
167MP0009840_abnormal_foam_cell0.58156288

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)7.45665522
2Muscle fiber inclusion bodies (HP:0100299)7.37393452
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.16023407
4Exercise-induced myalgia (HP:0003738)5.40864165
5Exercise-induced muscle cramps (HP:0003710)5.16476575
6Rhabdomyolysis (HP:0003201)4.52870342
7Renal cortical cysts (HP:0000803)4.34335269
8Type 1 muscle fiber predominance (HP:0003803)4.17898422
9Muscle hypertrophy of the lower extremities (HP:0008968)4.15856143
10Prolonged partial thromboplastin time (HP:0003645)4.09601698
11Increased serum pyruvate (HP:0003542)3.98253061
12Calf muscle hypertrophy (HP:0008981)3.96426685
13Distal arthrogryposis (HP:0005684)3.89230042
14Myoglobinuria (HP:0002913)3.89015304
15Hyporeflexia of lower limbs (HP:0002600)3.76239003
16Alopecia of scalp (HP:0002293)3.64158982
17Joint hemorrhage (HP:0005261)3.60850354
18Abnormality of glycolysis (HP:0004366)3.58541930
19Chronic hepatic failure (HP:0100626)3.49516452
20Subaortic stenosis (HP:0001682)3.43322210
21Abnormality of the left ventricular outflow tract (HP:0011103)3.43322210
22Conjugated hyperbilirubinemia (HP:0002908)3.39892137
23Follicular hyperkeratosis (HP:0007502)3.29111754
24Vascular calcification (HP:0004934)3.26469062
25Sudden death (HP:0001699)3.26418763
26Muscle fiber splitting (HP:0003555)3.25479254
27EMG: myopathic abnormalities (HP:0003458)3.14973450
28Osteomalacia (HP:0002749)3.10632192
29Abnormality of the calf musculature (HP:0001430)3.07446802
30Congenital stationary night blindness (HP:0007642)3.07208117
31Abnormality of incisor morphology (HP:0011063)3.05914465
32Cardiovascular calcification (HP:0011915)3.00512460
33Facial diplegia (HP:0001349)2.99942416
34Intrahepatic cholestasis (HP:0001406)2.97257730
35Areflexia of lower limbs (HP:0002522)2.96867816
36Rimmed vacuoles (HP:0003805)2.94909860
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93265793
38Enlarged kidneys (HP:0000105)2.92880366
39Hyperlipoproteinemia (HP:0010980)2.84954452
40Congenital sensorineural hearing impairment (HP:0008527)2.84305224
41Hyperglycinuria (HP:0003108)2.77455722
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77447255
43Gastrointestinal infarctions (HP:0005244)2.77196371
44Neck muscle weakness (HP:0000467)2.77065251
45Ventricular tachycardia (HP:0004756)2.76951314
46Progressive macrocephaly (HP:0004481)2.70215917
47Bundle branch block (HP:0011710)2.68907104
48Abnormality of the renal cortex (HP:0011035)2.66598335
49Epidermoid cyst (HP:0200040)2.62797513
50Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58941073
51Palpitations (HP:0001962)2.57280899
52Aplasia cutis congenita (HP:0001057)2.55144098
53Difficulty running (HP:0009046)2.53492647
54Hypoglycemic seizures (HP:0002173)2.53371055
55Neoplasm of the adrenal gland (HP:0100631)2.52213397
56Thyroid-stimulating hormone excess (HP:0002925)2.52198093
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49538795
58Deep venous thrombosis (HP:0002625)2.49159650
59Parakeratosis (HP:0001036)2.49087300
60Acute necrotizing encephalopathy (HP:0006965)2.46979065
61Xanthomatosis (HP:0000991)2.46876473
62Myopathic facies (HP:0002058)2.46149603
63Hypoglycemic coma (HP:0001325)2.43662288
64Pigmentary retinal degeneration (HP:0001146)2.43454892
65Abnormality of skeletal muscle fiber size (HP:0012084)2.43250352
66Decreased central vision (HP:0007663)2.42995341
67Asymmetric septal hypertrophy (HP:0001670)2.42540475
68Abnormality of methionine metabolism (HP:0010901)2.42139699
69Hypoalphalipoproteinemia (HP:0003233)2.42133907
70Hypophosphatemic rickets (HP:0004912)2.41636130
71Prostate neoplasm (HP:0100787)2.41351556
72Chromsome breakage (HP:0040012)2.38899385
73Complement deficiency (HP:0004431)2.36381843
74Febrile seizures (HP:0002373)2.34794782
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.33358229
76Symptomatic seizures (HP:0011145)2.32810179
77Submucous cleft hard palate (HP:0000176)2.31903264
78Abnormal mitochondria in muscle tissue (HP:0008316)2.30269739
79Fair hair (HP:0002286)2.30226383
80Alveolar cell carcinoma (HP:0006519)2.28799438
81Increased intramyocellular lipid droplets (HP:0012240)2.27377361
82Chest pain (HP:0100749)2.26962147
83Myocardial infarction (HP:0001658)2.26442321
84Absent phalangeal crease (HP:0006109)2.26410994
85EMG: neuropathic changes (HP:0003445)2.25606463
86Abnormality of pyrimidine metabolism (HP:0004353)2.25267664
87Generalized hypopigmentation of hair (HP:0011358)2.23474114
88Round ear (HP:0100830)2.23043510
89Recurrent gram-negative bacterial infections (HP:0005420)2.21661235
90Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21396395
91Calcaneovalgus deformity (HP:0001848)2.19456940
92Dilated cardiomyopathy (HP:0001644)2.17902840
93Acute encephalopathy (HP:0006846)2.17803002
94Abnormality of serine family amino acid metabolism (HP:0010894)2.17256006
95Abnormality of glycine metabolism (HP:0010895)2.17256006
96Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16765222
97White forelock (HP:0002211)2.16679938
98Recurrent corneal erosions (HP:0000495)2.16602180
99Abnormality of sulfur amino acid metabolism (HP:0004339)2.15447654
100Abnormality of the nasal septum (HP:0000419)2.14451136
101Duplicated collecting system (HP:0000081)2.13667479
102Dyschromatopsia (HP:0007641)2.12716675
103Mitochondrial inheritance (HP:0001427)2.09694202
104Ectropion (HP:0000656)2.08654202
105Deformed tarsal bones (HP:0008119)2.07688737
106Hypolipoproteinemia (HP:0010981)2.07286628
107Neoplasm of the tracheobronchial system (HP:0100552)2.06796471
108Thyroid carcinoma (HP:0002890)2.06173218
109Abnormality of the renal collecting system (HP:0004742)2.05468252
110Hypoplasia of the fovea (HP:0007750)2.04528809
111Aplasia/Hypoplasia of the fovea (HP:0008060)2.04528809
112Patchy hypopigmentation of hair (HP:0011365)2.04078331
113Pheochromocytoma (HP:0002666)2.02880124
114Generalized aminoaciduria (HP:0002909)2.02466915
115Dry hair (HP:0011359)2.02364115
116Neoplasm of the adrenal cortex (HP:0100641)2.01281627
117Abnormality of monocarboxylic acid metabolism (HP:0010996)2.01095345
118Increased hepatocellular lipid droplets (HP:0006565)2.00689531
119Recurrent abscess formation (HP:0002722)1.99161417
120Proximal tubulopathy (HP:0000114)1.98664654
121Papillary thyroid carcinoma (HP:0002895)1.97836117
122Muscle stiffness (HP:0003552)1.97245015
123Chronic diarrhea (HP:0002028)1.96962353
124Ketoacidosis (HP:0001993)1.96769063
125Ketosis (HP:0001946)1.96725863
126Abnormality of the columella (HP:0009929)1.96546116
127Bile duct proliferation (HP:0001408)1.95888347
128Abnormal biliary tract physiology (HP:0012439)1.95888347
129Arterial thrombosis (HP:0004420)1.95817960
130Exertional dyspnea (HP:0002875)1.95708464
131Upper limb muscle weakness (HP:0003484)1.95667428
132Heart block (HP:0012722)1.95635401
133Abnormality of the common coagulation pathway (HP:0010990)1.92864060
134Frequent falls (HP:0002359)1.92587729
135Distal lower limb muscle weakness (HP:0009053)1.91730206
136Increased CSF lactate (HP:0002490)1.91024093
137Hypobetalipoproteinemia (HP:0003563)1.90913719
138Lipid accumulation in hepatocytes (HP:0006561)1.90756528
139Hypothermia (HP:0002045)1.90414351
140Ulnar deviation of the wrist (HP:0003049)1.89161015
141Recurrent bacterial skin infections (HP:0005406)1.88905371
142Abnormal finger flexion creases (HP:0006143)1.88070035
143Abnormality of proline metabolism (HP:0010907)1.87947295
144Hydroxyprolinuria (HP:0003080)1.87947295
145Stomatitis (HP:0010280)1.87210853
146Increased muscle lipid content (HP:0009058)1.87021788
147Acute hepatic failure (HP:0006554)1.86983685
148Hyperglycinemia (HP:0002154)1.86863002
149Exercise intolerance (HP:0003546)1.86630653
150Nasolacrimal duct obstruction (HP:0000579)1.86318122
151Hepatic necrosis (HP:0002605)1.86181002
152Metabolic acidosis (HP:0001942)1.85884128
153Cerebral edema (HP:0002181)1.85039641
154Gingival bleeding (HP:0000225)1.84366731
155Cheilitis (HP:0100825)1.83501856
156Neuroendocrine neoplasm (HP:0100634)1.83414546
157Fat malabsorption (HP:0002630)1.82962549
158Tetraparesis (HP:0002273)1.82642528
159Conjunctival hamartoma (HP:0100780)1.80187908
160Neonatal hypoglycemia (HP:0001998)1.79653219
161Lipoatrophy (HP:0100578)1.79363731
162Chorioretinal atrophy (HP:0000533)1.78848363
163Abnormality of serum amino acid levels (HP:0003112)1.78422008
164Opisthotonus (HP:0002179)1.78083118
165Rickets (HP:0002748)1.77657718
166Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76612606
167Dicarboxylic aciduria (HP:0003215)1.76612606
168Agammaglobulinemia (HP:0004432)1.76421946
169Malignant hyperthermia (HP:0002047)1.76121247
170Hyperammonemia (HP:0001987)1.75234627
171Septo-optic dysplasia (HP:0100842)1.74916746
172Increased variability in muscle fiber diameter (HP:0003557)1.74325549
173Nausea (HP:0002018)1.73653118
174Thyroiditis (HP:0100646)1.73378377
175Renal Fanconi syndrome (HP:0001994)1.72642474
176Hypochromic microcytic anemia (HP:0004840)1.72556363
177Tinnitus (HP:0000360)1.72133521
178Ventricular arrhythmia (HP:0004308)1.71848201
179Meningioma (HP:0002858)1.71048567
180Abnormality of fatty-acid metabolism (HP:0004359)1.70927363
181Abnormality of dental color (HP:0011073)1.70827179
182Generalized muscle weakness (HP:0003324)1.70799069
183Abnormality of nucleobase metabolism (HP:0010932)1.69694172
184Corneal dystrophy (HP:0001131)1.69646682
185Fatigue (HP:0012378)1.68651456
186True hermaphroditism (HP:0010459)1.68625182
187Dynein arm defect of respiratory motile cilia (HP:0012255)1.68544545
188Pancreatic islet-cell hyperplasia (HP:0004510)1.65672367
189Myotonia (HP:0002486)1.63787203
190Lactic acidosis (HP:0003128)1.62989920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.46764642
2MKNK23.99600554
3INSRR3.94186577
4MAP3K123.46908727
5MAP3K142.59367431
6ZAK2.47093512
7CASK2.44448962
8MKNK12.40194987
9SIK32.33494658
10RIPK42.31797631
11IRAK32.29034372
12TTN2.25113377
13PHKG22.22552263
14PHKG12.22552263
15TXK2.04992360
16SCYL22.01361191
17NEK11.96175549
18EIF2AK31.91435664
19FRK1.86964915
20CDK191.86400162
21GRK11.83989961
22EIF2AK11.83463033
23SIK11.74877579
24MAP2K71.72467928
25ADRBK21.67526359
26EIF2AK21.63774658
27EPHB21.57863779
28TRPM71.53714760
29STK161.53023535
30BMPR1B1.48042024
31NUAK11.45786792
32MAP2K41.42215221
33MAPK71.37391093
34SGK21.33950235
35STK241.31080464
36STK38L1.30371986
37PIK3CA1.26702577
38NEK61.23828646
39YES11.21281209
40TIE11.19722430
41MAP2K31.18641429
42PINK11.17924008
43PLK41.16365167
44IRAK41.15553591
45GRK71.14408866
46CDK31.11143252
47FES1.10073864
48BLK1.08186524
49NLK1.06731339
50PRPF4B1.06217442
51SYK1.00785881
52TNK21.00180468
53LATS10.98465192
54IKBKE0.96391208
55MYLK0.96047631
56CCNB10.94812064
57PRKAA20.94479775
58SGK30.93538337
59OXSR10.91795429
60TAOK30.89850913
61MAP3K50.88733503
62GRK60.88169969
63RPS6KA40.87258634
64SGK2230.87011368
65SGK4940.87011368
66BRD40.85515234
67PLK30.85441990
68AKT30.84645283
69BUB10.83331556
70PRKCE0.82928036
71MAPK130.80017427
72PDK20.79837734
73DYRK30.75795521
74IKBKB0.75200884
75MAP3K20.75026000
76JAK10.74812970
77KIT0.73766942
78BCKDK0.73241181
79TAOK20.72492580
80PKN10.72319251
81IRAK10.71031377
82FGFR20.70709881
83JAK20.70386971
84BMPR20.69499521
85MUSK0.69036244
86EPHA30.68563035
87TGFBR20.68534034
88BRSK20.67398947
89NEK90.66015493
90TYK20.65935515
91MAP3K70.64145273
92ROCK10.63941767
93NTRK30.62201226
94STK40.62123950
95FGFR40.60881022
96FGFR30.59733201
97ERBB40.59608411
98TEC0.59575283
99SIK20.58885298
100BTK0.58416039
101SGK10.57551701
102VRK10.57512139
103JAK30.56994455
104TRIM280.56209409
105OBSCN0.53533088
106FLT30.53524642
107ERBB30.53257013
108RPS6KB20.52228351
109MAPK120.51822800
110CAMK1D0.51732064
111PRKCQ0.51016684
112MAP3K60.50987568
113CHUK0.50208146
114CAMKK20.49020221
115HCK0.48658295
116PLK20.48294702
117MST1R0.48049902
118IGF1R0.47748849
119PRKCG0.47358366
120CDK80.44313422
121CAMK40.44236049
122RPS6KB10.43987193
123PIK3CG0.43079876
124LYN0.42390450
125LRRK20.41629297
126CAMK1G0.41628553
127MST40.40716223
128CSK0.40190209
129MAPK150.39964969
130ADRBK10.39146094
131IRAK20.38701152
132WNK30.38048464
133STK30.36925250
134PRKG10.34759401
135ILK0.34620739
136MAPK110.34152002
137ERBB20.33891935
138VRK20.33767996
139CDK90.33266380
140TBK10.32373947
141WNK10.31377424
142SRPK10.31296876
143PRKACB0.31283354
144PRKAA10.30634128
145PRKACA0.30492096
146FER0.30271541
147PBK0.30266550
148PDK10.28064803
149RPS6KA50.27632376
150MAP3K10.27253784

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.85272251
2Asthma_Homo sapiens_hsa053102.83601935
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.65828278
4Tryptophan metabolism_Homo sapiens_hsa003802.58085047
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46356080
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.40478735
7Fatty acid degradation_Homo sapiens_hsa000712.36036360
8beta-Alanine metabolism_Homo sapiens_hsa004102.28203431
9Peroxisome_Homo sapiens_hsa041462.23719682
10Complement and coagulation cascades_Homo sapiens_hsa046102.21199765
11Propanoate metabolism_Homo sapiens_hsa006402.20109995
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17642712
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.16251667
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13196093
15Proteasome_Homo sapiens_hsa030502.11860102
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.10776701
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06140420
18Non-homologous end-joining_Homo sapiens_hsa034502.03216898
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01932431
20Staphylococcus aureus infection_Homo sapiens_hsa051501.98583561
21PPAR signaling pathway_Homo sapiens_hsa033201.96558993
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94141906
23Chemical carcinogenesis_Homo sapiens_hsa052041.93772874
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93392116
25Fatty acid metabolism_Homo sapiens_hsa012121.91591203
26Histidine metabolism_Homo sapiens_hsa003401.90517401
27Butanoate metabolism_Homo sapiens_hsa006501.87378690
28Leishmaniasis_Homo sapiens_hsa051401.86548294
29Fatty acid elongation_Homo sapiens_hsa000621.84367969
30Parkinsons disease_Homo sapiens_hsa050121.83557477
31Vitamin digestion and absorption_Homo sapiens_hsa049771.80649313
32Retinol metabolism_Homo sapiens_hsa008301.79488697
33Carbon metabolism_Homo sapiens_hsa012001.71460576
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62711580
35Oxidative phosphorylation_Homo sapiens_hsa001901.60758041
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.59640145
37ABC transporters_Homo sapiens_hsa020101.58532506
38Systemic lupus erythematosus_Homo sapiens_hsa053221.56165897
39Arginine biosynthesis_Homo sapiens_hsa002201.53398531
40Viral myocarditis_Homo sapiens_hsa054161.49779425
41Starch and sucrose metabolism_Homo sapiens_hsa005001.48595605
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48337665
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45416933
44Cardiac muscle contraction_Homo sapiens_hsa042601.43764383
45Phototransduction_Homo sapiens_hsa047441.40879745
46Legionellosis_Homo sapiens_hsa051341.37388836
47Phenylalanine metabolism_Homo sapiens_hsa003601.35130237
48Steroid biosynthesis_Homo sapiens_hsa001001.29785377
49Type I diabetes mellitus_Homo sapiens_hsa049401.29178095
50Arginine and proline metabolism_Homo sapiens_hsa003301.27957996
51Antigen processing and presentation_Homo sapiens_hsa046121.24584476
52Tyrosine metabolism_Homo sapiens_hsa003501.20583937
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18671334
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16139974
55Alzheimers disease_Homo sapiens_hsa050101.13663197
56Sulfur metabolism_Homo sapiens_hsa009201.12676126
57Caffeine metabolism_Homo sapiens_hsa002321.10179606
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08900211
59Autoimmune thyroid disease_Homo sapiens_hsa053201.08374060
60* Lysine degradation_Homo sapiens_hsa003101.07466909
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.05044939
62Glycerolipid metabolism_Homo sapiens_hsa005610.98071831
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.97390145
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94847516
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94305833
66Pentose phosphate pathway_Homo sapiens_hsa000300.89265439
67Tuberculosis_Homo sapiens_hsa051520.88913432
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86571166
69Bile secretion_Homo sapiens_hsa049760.85011987
70Dilated cardiomyopathy_Homo sapiens_hsa054140.84749486
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84352525
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82050945
73Fatty acid biosynthesis_Homo sapiens_hsa000610.81598794
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.81492310
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78964647
76Homologous recombination_Homo sapiens_hsa034400.78953630
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77929867
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77204414
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74080039
80Arachidonic acid metabolism_Homo sapiens_hsa005900.71954842
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70811280
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.68683268
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.68609462
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68470295
85Huntingtons disease_Homo sapiens_hsa050160.68279311
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68059635
87Platelet activation_Homo sapiens_hsa046110.66461818
88Insulin resistance_Homo sapiens_hsa049310.66249432
89Selenocompound metabolism_Homo sapiens_hsa004500.65549597
90Sphingolipid metabolism_Homo sapiens_hsa006000.65309253
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64137482
92Glucagon signaling pathway_Homo sapiens_hsa049220.63989618
93Other glycan degradation_Homo sapiens_hsa005110.63314185
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62960617
95Fat digestion and absorption_Homo sapiens_hsa049750.62197819
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.61601999
97Ovarian steroidogenesis_Homo sapiens_hsa049130.61181079
98Pyruvate metabolism_Homo sapiens_hsa006200.61166252
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61049548
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60544261
101Protein export_Homo sapiens_hsa030600.60142233
102Toxoplasmosis_Homo sapiens_hsa051450.57964355
103Circadian rhythm_Homo sapiens_hsa047100.57717010
104Mineral absorption_Homo sapiens_hsa049780.56427627
105RNA degradation_Homo sapiens_hsa030180.55690658
106Graft-versus-host disease_Homo sapiens_hsa053320.55148808
107Allograft rejection_Homo sapiens_hsa053300.53610917
108Herpes simplex infection_Homo sapiens_hsa051680.51073012
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.50810465
110Insulin signaling pathway_Homo sapiens_hsa049100.50763071
111Rheumatoid arthritis_Homo sapiens_hsa053230.49166209
112Metabolic pathways_Homo sapiens_hsa011000.47412068
113Primary immunodeficiency_Homo sapiens_hsa053400.47201811
114Glutathione metabolism_Homo sapiens_hsa004800.46194936
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44883845
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44746589
117Vitamin B6 metabolism_Homo sapiens_hsa007500.44080441
118Influenza A_Homo sapiens_hsa051640.43828872
119Malaria_Homo sapiens_hsa051440.42217901
120Nitrogen metabolism_Homo sapiens_hsa009100.41145252
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.40692223
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40275998
123Mismatch repair_Homo sapiens_hsa034300.40012528
124Biosynthesis of amino acids_Homo sapiens_hsa012300.39321535
125Melanoma_Homo sapiens_hsa052180.37698192
126Base excision repair_Homo sapiens_hsa034100.36498248
127Measles_Homo sapiens_hsa051620.33994736
128One carbon pool by folate_Homo sapiens_hsa006700.32691324
129Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32072005
130Linoleic acid metabolism_Homo sapiens_hsa005910.31970740
131AMPK signaling pathway_Homo sapiens_hsa041520.31394573
132Folate biosynthesis_Homo sapiens_hsa007900.31176501
133Hematopoietic cell lineage_Homo sapiens_hsa046400.29800069
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.29537799
135Fanconi anemia pathway_Homo sapiens_hsa034600.28352126
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28038132
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28009322
138Ether lipid metabolism_Homo sapiens_hsa005650.26531678
1392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25953309
140Taste transduction_Homo sapiens_hsa047420.25511763
141Phagosome_Homo sapiens_hsa041450.24901708
142ECM-receptor interaction_Homo sapiens_hsa045120.23289310
143Nicotine addiction_Homo sapiens_hsa050330.22904773
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22695396
145Regulation of autophagy_Homo sapiens_hsa041400.22533779

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