TMOD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle adaptation (GO:0043501)9.56172327
2skeletal muscle fiber development (GO:0048741)7.80574087
3actin filament-based movement (GO:0030048)7.66665699
4plasma membrane repair (GO:0001778)7.61658773
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.16840984
6sarcomere organization (GO:0045214)6.85076156
7striated muscle contraction (GO:0006941)6.64820508
8myotube cell development (GO:0014904)6.63657600
9creatine metabolic process (GO:0006600)6.50740875
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.49536567
11glycogen catabolic process (GO:0005980)6.43114176
12skeletal muscle tissue regeneration (GO:0043403)6.17881729
13myofibril assembly (GO:0030239)6.11413906
14carnitine shuttle (GO:0006853)6.05848474
15glucan catabolic process (GO:0009251)6.02093981
16pyrimidine ribonucleoside catabolic process (GO:0046133)5.94281499
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.77989273
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.77640774
19purine nucleotide salvage (GO:0032261)5.73288196
20response to muscle activity (GO:0014850)5.64118924
21regulation of cell communication by electrical coupling (GO:0010649)5.62596709
22cytidine deamination (GO:0009972)5.62561299
23cytidine metabolic process (GO:0046087)5.62561299
24cytidine catabolic process (GO:0006216)5.62561299
25striated muscle atrophy (GO:0014891)5.61787640
26cellular polysaccharide catabolic process (GO:0044247)5.58129151
27polysaccharide catabolic process (GO:0000272)5.46585146
28response to inactivity (GO:0014854)5.45849019
29* muscle contraction (GO:0006936)5.33980583
30glycogen biosynthetic process (GO:0005978)5.19188282
31glucan biosynthetic process (GO:0009250)5.19188282
32striated muscle adaptation (GO:0014888)5.11679374
33fatty acid transmembrane transport (GO:1902001)5.10594159
34NADH metabolic process (GO:0006734)5.07304160
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.99526746
36muscle fiber development (GO:0048747)4.87368052
37muscle atrophy (GO:0014889)4.86059135
38IMP metabolic process (GO:0046040)4.79950666
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.76894165
40* muscle system process (GO:0003012)4.75606542
41actomyosin structure organization (GO:0031032)4.71303607
42fructose metabolic process (GO:0006000)4.64467717
43positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.60542737
44carnitine transmembrane transport (GO:1902603)4.59977900
45regulation of acyl-CoA biosynthetic process (GO:0050812)4.56400891
46cardiac muscle hypertrophy (GO:0003300)4.46288618
47glycogen metabolic process (GO:0005977)4.42166213
48muscle organ morphogenesis (GO:0048644)4.41991926
49glucan metabolic process (GO:0044042)4.33302010
50cellular glucan metabolic process (GO:0006073)4.33302010
51striated muscle hypertrophy (GO:0014897)4.26180637
52amino-acid betaine transport (GO:0015838)4.19635582
53carnitine transport (GO:0015879)4.19635582
54gluconeogenesis (GO:0006094)4.17995893
55regulation of relaxation of muscle (GO:1901077)4.13939420
56muscle adaptation (GO:0043500)4.13868850
57cardiac muscle contraction (GO:0060048)4.13355023
58regulation of coenzyme metabolic process (GO:0051196)4.08833163
59regulation of cofactor metabolic process (GO:0051193)4.08833163
60muscle cell fate commitment (GO:0042693)4.05965313
61regulation of skeletal muscle cell differentiation (GO:2001014)3.94450466
62regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.91686052
63response to activity (GO:0014823)3.89916131
64negative regulation of muscle hypertrophy (GO:0014741)3.86454751
65neuronal action potential propagation (GO:0019227)3.86047217
66negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.85327097
67tricarboxylic acid cycle (GO:0006099)3.82332483
68muscle tissue morphogenesis (GO:0060415)3.81360500
69muscle hypertrophy (GO:0014896)3.81084021
70muscle organ development (GO:0007517)3.76805476
71striated muscle cell development (GO:0055002)3.76721606
72hexose biosynthetic process (GO:0019319)3.74481303
73muscle structure development (GO:0061061)3.74305429
74muscle cell cellular homeostasis (GO:0046716)3.68251186
75heart contraction (GO:0060047)3.68076256
76heart process (GO:0003015)3.68076256
77negative regulation of potassium ion transmembrane transport (GO:1901380)3.67133233
78negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.66825596
79negative regulation of calcium ion transmembrane transport (GO:1903170)3.66825596
80negative regulation of skeletal muscle tissue development (GO:0048642)3.66806625
81cardiac myofibril assembly (GO:0055003)3.61435718
82ubiquinone biosynthetic process (GO:0006744)3.61370577
83adult heart development (GO:0007512)3.60796167
84cellular response to dexamethasone stimulus (GO:0071549)3.60287303
85cardiac muscle tissue morphogenesis (GO:0055008)3.57079409
86cellular carbohydrate catabolic process (GO:0044275)3.56487150
87IMP biosynthetic process (GO:0006188)3.56168708
88regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.53790994
89negative regulation of muscle contraction (GO:0045932)3.50289519
90regulation of actin filament-based movement (GO:1903115)3.46576558
91skeletal muscle tissue development (GO:0007519)3.43510672
92regulation of striated muscle contraction (GO:0006942)3.39222731
93regulation of calcium ion transmembrane transporter activity (GO:1901019)3.38320338
94regulation of calcium ion transmembrane transport (GO:1903169)3.38320338
95cardiac muscle hypertrophy in response to stress (GO:0014898)3.37227787
96muscle hypertrophy in response to stress (GO:0003299)3.37227787
97cardiac muscle adaptation (GO:0014887)3.37227787
98neuromuscular synaptic transmission (GO:0007274)3.36922629
99response to dexamethasone (GO:0071548)3.35853038
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.35671221
101regulation of sulfur metabolic process (GO:0042762)3.34296786
102striated muscle tissue development (GO:0014706)3.32970365
103AMP metabolic process (GO:0046033)3.30525538
104positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.29672896
105syncytium formation by plasma membrane fusion (GO:0000768)3.26321586
106regulation of myoblast differentiation (GO:0045661)3.25893952
107myotube differentiation (GO:0014902)3.25498171
108positive regulation of myotube differentiation (GO:0010831)3.25051736
109positive regulation of cation channel activity (GO:2001259)3.22558710
110relaxation of muscle (GO:0090075)3.21812219
111cardiac muscle cell development (GO:0055013)3.21135141
112succinate metabolic process (GO:0006105)3.20720161
113muscle cell development (GO:0055001)3.20572993
114intracellular lipid transport (GO:0032365)3.19421508
115regulation of sequestering of triglyceride (GO:0010889)3.18867126
116negative regulation of cAMP-mediated signaling (GO:0043951)3.18857098
117ubiquinone metabolic process (GO:0006743)3.18451273
1182-oxoglutarate metabolic process (GO:0006103)3.13809322
119myoblast fusion (GO:0007520)3.12638289
120cellular polysaccharide metabolic process (GO:0044264)3.07848541
121cellular polysaccharide biosynthetic process (GO:0033692)3.06004383
122polysaccharide biosynthetic process (GO:0000271)3.01482147
123muscle filament sliding (GO:0030049)12.5602837
124actin-myosin filament sliding (GO:0033275)12.5602837
125regulation of skeletal muscle contraction (GO:0014819)12.1030958
126skeletal muscle contraction (GO:0003009)10.8777406
127actin-mediated cell contraction (GO:0070252)10.2810904
128sarcoplasmic reticulum calcium ion transport (GO:0070296)10.2113163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.49832093
2EZH2_22144423_ChIP-Seq_EOC_Human4.88329905
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.79709723
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.66049228
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.41461316
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.34415480
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.30764208
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.07263373
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.75449373
10ZNF263_19887448_ChIP-Seq_K562_Human2.72386669
11TBX20_22080862_ChIP-Seq_HEART_Mouse2.64834222
12TBX20_22328084_ChIP-Seq_HEART_Mouse2.64834222
13BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.35293766
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33408362
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32113288
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23792736
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12391214
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03269859
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.93298428
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89030961
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84348680
22MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.80605236
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78040324
24AR_21572438_ChIP-Seq_LNCaP_Human1.78018805
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.76960778
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.75973068
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75215667
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.71362240
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.65014651
30* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.63172680
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.62178705
32CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56424384
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.52869042
34ZNF274_21170338_ChIP-Seq_K562_Hela1.52453869
35* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.50476759
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47934835
37* CTCF_27219007_Chip-Seq_Bcells_Human1.47046438
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47018061
39PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44344268
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41022384
41FOXH1_21741376_ChIP-Seq_ESCs_Human1.36870386
42CLOCK_20551151_ChIP-Seq_293T_Human1.34580693
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34555144
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30634890
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23854560
46* SA1_27219007_Chip-Seq_Bcells_Human1.22804779
47STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.21542569
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21356664
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20805329
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.19861068
51GATA4_21415370_ChIP-Seq_HL-1_Mouse1.17505265
52OCT4_20526341_ChIP-Seq_ESCs_Human1.17062917
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.16983809
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.15404715
55SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13807430
56KDM2B_26808549_Chip-Seq_DND41_Human1.13689676
57SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12944250
58IGF1R_20145208_ChIP-Seq_DFB_Human1.11631070
59VDR_22108803_ChIP-Seq_LS180_Human1.10327838
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09815704
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08634316
62RACK7_27058665_Chip-Seq_MCF-7_Human1.08448115
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.07890295
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07801890
65STAT1_20625510_ChIP-Seq_HELA_Human1.07227129
66* CTCF_21964334_Chip-Seq_Bcells_Human1.07211474
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07059000
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.06136892
69TCF7_22412390_ChIP-Seq_EML_Mouse1.05310804
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04868620
71ATF3_27146783_Chip-Seq_COLON_Human1.04305137
72SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03687415
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.03319871
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03072597
75CBP_20019798_ChIP-Seq_JUKART_Human1.03072597
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02875540
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02452514
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.02446965
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01276287
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.01261736
81CREB1_26743006_Chip-Seq_LNCaP_Human1.01149371
82TP63_22573176_ChIP-Seq_HFKS_Human1.00175834
83MYC_27129775_Chip-Seq_CORNEA_Mouse0.99393787
84CJUN_26792858_Chip-Seq_BT549_Human0.98600640
85CEBPB_22108803_ChIP-Seq_LS180_Human0.98122968
86NANOG_20526341_ChIP-Seq_ESCs_Human0.97704074
87CBX2_27304074_Chip-Seq_ESCs_Mouse0.97594799
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97106595
89P68_20966046_ChIP-Seq_HELA_Human0.96321607
90LXR_22292898_ChIP-Seq_THP-1_Human0.95022399
91P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94422261
92ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94367883
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93791240
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92722154
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.92529931
96RAC3_21632823_ChIP-Seq_H3396_Human0.92330941
97DROSHA_22980978_ChIP-Seq_HELA_Human0.92192483
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91282206
99SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91160955
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90764449
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90604477
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90148514
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90090606
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90019685
105* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89663150
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.88625567
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87727443
108EGR1_19032775_ChIP-ChIP_M12_Human0.87557024
109RUNX1_27514584_Chip-Seq_MCF-7_Human0.87216566
110GATA1_22025678_ChIP-Seq_K562_Human0.84902131
111* CTCF_26484167_Chip-Seq_Bcells_Mouse0.84665242
112SPI1_20517297_ChIP-Seq_HL60_Human0.84571986
113FLI1_27457419_Chip-Seq_LIVER_Mouse0.84411042
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83450531
115* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83139217
116DPY_21335234_ChIP-Seq_ESCs_Mouse0.82786982
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82510773
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81315479
119KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81201841
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80574870
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80574870
122HTT_18923047_ChIP-ChIP_STHdh_Human0.79503079
123CSB_26484114_Chip-Seq_FIBROBLAST_Human0.79320546
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78976433
125GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.78865917
126OCT1_27270436_Chip-Seq_PROSTATE_Human0.78857449
127P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.78791681
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.78756917
129PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.78737585
130GATA3_21867929_ChIP-Seq_CD8_Mouse0.78676375
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78601240
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78036322
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75589661
134FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.74812065
135CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.73224788
136* GATA6_21074721_ChIP-Seq_CACO-2_Human0.72215630
137ZFP281_18757296_ChIP-ChIP_E14_Mouse0.71018576
138ER_23166858_ChIP-Seq_MCF-7_Human0.70757848
139GATA1_19941827_ChIP-Seq_MEL86_Mouse0.69516426
140LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.68992000
141KLF5_20875108_ChIP-Seq_MESCs_Mouse0.68875743
142EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.66351706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio7.81614442
2MP0003646_muscle_fatigue6.49057336
3MP0000749_muscle_degeneration6.30788303
4MP0000751_myopathy5.57961340
5MP0000747_muscle_weakness4.33716128
6MP0002106_abnormal_muscle_physiology4.15876389
7MP0004036_abnormal_muscle_relaxation4.09996553
8MP0002837_dystrophic_cardiac_calcinosis3.85868194
9MP0000759_abnormal_skeletal_muscle3.75460177
10MP0002269_muscular_atrophy3.53009738
11MP0005369_muscle_phenotype3.46839206
12MP0004087_abnormal_muscle_fiber3.42730910
13MP0004130_abnormal_muscle_cell3.37246836
14MP0000750_abnormal_muscle_regeneration3.30713896
15MP0005620_abnormal_muscle_contractility3.18249476
16MP0004233_abnormal_muscle_weight2.53311828
17MP0002332_abnormal_exercise_endurance2.25690183
18MP0000733_abnormal_muscle_development2.20925637
19MP0005330_cardiomyopathy2.14790612
20MP0002108_abnormal_muscle_morphology1.97983520
21MP0006036_abnormal_mitochondrial_physio1.94834678
22MP0004084_abnormal_cardiac_muscle1.88729374
23MP0004185_abnormal_adipocyte_glucose1.74827549
24MP0004215_abnormal_myocardial_fiber1.60897074
25MP0004484_altered_response_of1.46296927
26MP0002972_abnormal_cardiac_muscle1.45037881
27MP0005666_abnormal_adipose_tissue1.42171605
28MP0010630_abnormal_cardiac_muscle1.31113199
29MP0002971_abnormal_brown_adipose1.29888639
30MP0003221_abnormal_cardiomyocyte_apopto1.24683552
31MP0003806_abnormal_nucleotide_metabolis1.15468865
32MP0005385_cardiovascular_system_phenoty1.06775737
33MP0001544_abnormal_cardiovascular_syste1.06775737
34MP0002822_catalepsy1.04444447
35MP0005375_adipose_tissue_phenotype1.03022810
36MP0005266_abnormal_metabolism1.02623130
37MP0004270_analgesia1.00339190
38MP0006035_abnormal_mitochondrial_morpho0.99749102
39MP0001661_extended_life_span0.98669012
40MP0000383_abnormal_hair_follicle0.94532351
41MP0000013_abnormal_adipose_tissue0.92359026
42MP0003137_abnormal_impulse_conducting0.90328793
43MP0003950_abnormal_plasma_membrane0.89766438
44MP0004147_increased_porphyrin_level0.88193039
45MP0000372_irregular_coat_pigmentation0.84807031
46MP0005275_abnormal_skin_tensile0.82269609
47MP0002234_abnormal_pharynx_morphology0.78980084
48MP0003705_abnormal_hypodermis_morpholog0.77372290
49MP0004043_abnormal_pH_regulation0.75698326
50MP0004134_abnormal_chest_morphology0.75524143
51MP0003656_abnormal_erythrocyte_physiolo0.74707254
52MP0008775_abnormal_heart_ventricle0.74013750
53MP0000762_abnormal_tongue_morphology0.71881248
54MP0009250_abnormal_appendicular_skeleto0.70696756
55MP0009780_abnormal_chondrocyte_physiolo0.68565626
56MP0002796_impaired_skin_barrier0.68247971
57MP0002127_abnormal_cardiovascular_syste0.64738819
58MP0008961_abnormal_basal_metabolism0.62358698
59MP0010678_abnormal_skin_adnexa0.60515261
60MP0005334_abnormal_fat_pad0.59650273
61MP0002078_abnormal_glucose_homeostasis0.57505320
62MP0003879_abnormal_hair_cell0.57474959
63MP0000343_altered_response_to0.57234347
64MP0003828_pulmonary_edema0.56587966
65MP0000266_abnormal_heart_morphology0.55497541
66MP0001299_abnormal_eye_distance/0.54475780
67MP0000003_abnormal_adipose_tissue0.52723216
68MP0006138_congestive_heart_failure0.52236121
69MP0005670_abnormal_white_adipose0.48344168
70MP0005584_abnormal_enzyme/coenzyme_acti0.43616250
71MP0005083_abnormal_biliary_tract0.43563585
72MP0002638_abnormal_pupillary_reflex0.42559165
73MP0005167_abnormal_blood-brain_barrier0.41290539
74MP0000579_abnormal_nail_morphology0.41094584
75MP0004085_abnormal_heartbeat0.40975014
76MP0005319_abnormal_enzyme/_coenzyme0.40271892
77MP0010030_abnormal_orbit_morphology0.39333084
78MP0005535_abnormal_body_temperature0.38652505
79MP0003045_fibrosis0.38532956
80MP0005166_decreased_susceptibility_to0.36910724
81MP0000230_abnormal_systemic_arterial0.35754440
82MP0001853_heart_inflammation0.35707669
83MP0002896_abnormal_bone_mineralization0.35443370
84MP0005452_abnormal_adipose_tissue0.34781571
85MP0005332_abnormal_amino_acid0.32535951
86MP0003959_abnormal_lean_body0.32418301
87MP0004510_myositis0.30492424
88MP0005423_abnormal_somatic_nervous0.30223718
89MP0003567_abnormal_fetal_cardiomyocyte0.29125107
90MP0002060_abnormal_skin_morphology0.29081273
91MP0002734_abnormal_mechanical_nocicepti0.28631457
92MP0008569_lethality_at_weaning0.28469314
93MP0001243_abnormal_dermal_layer0.28428209
94MP0002114_abnormal_axial_skeleton0.27452230
95MP0009672_abnormal_birth_weight0.26890584
96MP0001346_abnormal_lacrimal_gland0.26320865
97MP0004381_abnormal_hair_follicle0.25869257
98MP0003948_abnormal_gas_homeostasis0.25437686
99MP0009115_abnormal_fat_cell0.25265624
100MP0005165_increased_susceptibility_to0.25187214
101MP0003195_calcinosis0.24199230
102MP0002118_abnormal_lipid_homeostasis0.23578684
103MP0001849_ear_inflammation0.23556507
104MP0005376_homeostasis/metabolism_phenot0.23397517
105MP0005187_abnormal_penis_morphology0.22870296
106MP0000377_abnormal_hair_follicle0.22706548
107MP0002089_abnormal_postnatal_growth/wei0.22604582
108MP0002066_abnormal_motor_capabilities/c0.22329004
109MP0001943_abnormal_respiration0.22322033
110MP0010234_abnormal_vibrissa_follicle0.22133537
111MP0002128_abnormal_blood_circulation0.21818242
112MP0004142_abnormal_muscle_tone0.21505459
113MP0005501_abnormal_skin_physiology0.21278048
114MP0005451_abnormal_body_composition0.20743123
115MP0004858_abnormal_nervous_system0.17404421
116MP0002876_abnormal_thyroid_physiology0.16567352
117MP0002067_abnormal_sensory_capabilities0.16231274
118MP0005645_abnormal_hypothalamus_physiol0.14528088
119MP0008874_decreased_physiological_sensi0.13819246
120MP0005386_behavior/neurological_phenoty0.12673714
121MP0004924_abnormal_behavior0.12673714
122MP0006276_abnormal_autonomic_nervous0.12150060

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.93867873
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.46199028
3Nemaline bodies (HP:0003798)8.93001385
4Exercise-induced myalgia (HP:0003738)8.78081223
5Exercise-induced muscle cramps (HP:0003710)7.98495035
6Type 1 muscle fiber predominance (HP:0003803)7.28229484
7Distal arthrogryposis (HP:0005684)7.11744656
8Muscle hypertrophy of the lower extremities (HP:0008968)7.11093669
9Myopathic facies (HP:0002058)6.64645147
10Calf muscle hypertrophy (HP:0008981)6.33472292
11Round ear (HP:0100830)6.12425855
12Ulnar deviation of the wrist (HP:0003049)5.92991543
13Difficulty running (HP:0009046)5.44910766
14Myoglobinuria (HP:0002913)5.31799633
15Muscle fiber splitting (HP:0003555)5.18746930
16Calcaneovalgus deformity (HP:0001848)5.13089432
17Hyporeflexia of lower limbs (HP:0002600)4.99223762
18Absent phalangeal crease (HP:0006109)4.84244122
19Muscle stiffness (HP:0003552)4.83566032
20Deformed tarsal bones (HP:0008119)4.68371668
21EMG: myopathic abnormalities (HP:0003458)4.57237159
22Rhabdomyolysis (HP:0003201)4.46632843
23Increased connective tissue (HP:0009025)4.40371873
24Abnormality of the calf musculature (HP:0001430)4.21136418
25Myotonia (HP:0002486)4.14667230
26Abnormal finger flexion creases (HP:0006143)4.03800545
27Abnormality of skeletal muscle fiber size (HP:0012084)3.79555646
28Abnormality of the left ventricular outflow tract (HP:0011103)3.74246278
29Subaortic stenosis (HP:0001682)3.74246278
30Malignant hyperthermia (HP:0002047)3.54883797
31Neck muscle weakness (HP:0000467)3.50199731
32Rimmed vacuoles (HP:0003805)3.45417579
33Increased variability in muscle fiber diameter (HP:0003557)3.35717222
34Difficulty climbing stairs (HP:0003551)3.33314706
35Areflexia of lower limbs (HP:0002522)3.32404541
36Pelvic girdle muscle weakness (HP:0003749)3.12421662
37Frequent falls (HP:0002359)3.11578424
38Shoulder girdle muscle weakness (HP:0003547)3.10552007
39Abnormality of the calcaneus (HP:0008364)3.04795736
40Asymmetric septal hypertrophy (HP:0001670)3.03125548
41Abnormality of the hip-girdle musculature (HP:0001445)3.02944113
42Abnormality of the musculature of the pelvis (HP:0001469)3.02944113
43Sudden death (HP:0001699)2.95883203
44Hyperkalemia (HP:0002153)2.95293211
45Bundle branch block (HP:0011710)2.77163141
46Distal lower limb muscle weakness (HP:0009053)2.72825011
47Fatigable weakness (HP:0003473)2.64270320
48Abnormality of the neuromuscular junction (HP:0003398)2.64270320
49Paralysis (HP:0003470)2.53685504
50EMG: neuropathic changes (HP:0003445)2.53105411
51Slender build (HP:0001533)2.50756116
52Muscular dystrophy (HP:0003560)2.36799297
53Proximal amyotrophy (HP:0007126)2.29987401
54Hypoplastic ischia (HP:0003175)2.21805124
55Ventricular tachycardia (HP:0004756)2.21585839
56Mildly elevated creatine phosphokinase (HP:0008180)2.21162925
57Limb-girdle muscle weakness (HP:0003325)2.19454008
58Generalized muscle weakness (HP:0003324)2.18269466
59Facial diplegia (HP:0001349)2.17668273
60Bulbar palsy (HP:0001283)2.14494566
61Progressive muscle weakness (HP:0003323)2.13952935
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.09534697
63Scapular winging (HP:0003691)2.04627944
64Abnormality of the shoulder girdle musculature (HP:0001435)2.03797346
65Nonprogressive disorder (HP:0003680)2.03660179
66Ulnar deviation of finger (HP:0009465)2.02415747
67Weak cry (HP:0001612)2.01911812
68Limb-girdle muscle atrophy (HP:0003797)2.01844705
69Spinal rigidity (HP:0003306)2.01515470
70Distal lower limb amyotrophy (HP:0008944)2.00169631
71Gowers sign (HP:0003391)1.99259420
72Abnormality of the foot musculature (HP:0001436)1.93066753
73Abnormality of the ischium (HP:0003174)1.93057256
74Metatarsus adductus (HP:0001840)1.88883876
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85688808
76Ragged-red muscle fibers (HP:0003200)1.83401254
77Achilles tendon contracture (HP:0001771)1.82516576
78Heart block (HP:0012722)1.81506910
79Foot dorsiflexor weakness (HP:0009027)1.76935308
80Long clavicles (HP:0000890)1.74530007
81Lipoatrophy (HP:0100578)1.70609939
82Abnormal atrioventricular conduction (HP:0005150)1.69491750
83Waddling gait (HP:0002515)1.68639607
84Increased intramyocellular lipid droplets (HP:0012240)1.68102639
85Abnormality of the Achilles tendon (HP:0005109)1.66162858
86Dilated cardiomyopathy (HP:0001644)1.64054359
87Popliteal pterygium (HP:0009756)1.63167345
88Hip contracture (HP:0003273)1.61741682
89Fetal akinesia sequence (HP:0001989)1.60368547
90Tarsal synostosis (HP:0008368)1.58606770
91Cholelithiasis (HP:0001081)1.58346675
92Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.57882102
93Increased density of long bones (HP:0006392)1.56974909
94Increased muscle lipid content (HP:0009058)1.55905358
95Type 2 muscle fiber atrophy (HP:0003554)1.54419103
96Short palpebral fissure (HP:0012745)1.54296326
97Hyperuricemia (HP:0002149)1.54072321
98Increased purine levels (HP:0004368)1.54072321
99Abnormality of potassium homeostasis (HP:0011042)1.50457473
100Stridor (HP:0010307)1.49233938
101Exercise intolerance (HP:0003546)1.48889909
102Ventricular arrhythmia (HP:0004308)1.48759877
103Gout (HP:0001997)1.46302748
104Respiratory insufficiency due to muscle weakness (HP:0002747)1.44284996
105Muscle fiber atrophy (HP:0100295)1.44281888
106Lower limb amyotrophy (HP:0007210)1.44135288
107Toxemia of pregnancy (HP:0100603)1.42421449
108Oligomenorrhea (HP:0000876)1.41693270
109Synostosis involving bones of the feet (HP:0009140)1.40791216
110Synostosis involving bones of the lower limbs (HP:0009138)1.40791216
111Abnormal gallbladder morphology (HP:0012437)1.38740065
112Limited hip movement (HP:0008800)1.38660590
113Insulin-resistant diabetes mellitus (HP:0000831)1.35886251
114Adducted thumb (HP:0001181)1.35620098
115Congenital hip dislocation (HP:0001374)1.29431812
116Steppage gait (HP:0003376)1.24063317
117Amniotic constriction ring (HP:0009775)1.21608606
118Abnormality of placental membranes (HP:0011409)1.21608606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.62000282
2TTN6.57835394
3PHKG15.41587790
4PHKG25.41587790
5NME14.33449570
6PIK3CG3.56488207
7MAP2K33.00277582
8MAP3K72.17779044
9PINK12.13884186
10NEK12.12997646
11PDK41.99253589
12PDK31.99253589
13DMPK1.88404959
14TRIB31.72015566
15PIK3CA1.70299045
16MAPK121.66455806
17BCKDK1.64535674
18MAP2K41.61237023
19MAP2K61.43999819
20MUSK1.34738427
21PDK21.34715645
22MAP3K31.10702521
23MAPKAPK31.06447727
24STK240.96128665
25TRPM70.91452629
26PRKAA20.91369026
27MARK10.90634313
28CCNB10.90618233
29PRKAA10.81456286
30NEK90.80297873
31ERBB30.80198929
32MAP3K130.69335961
33PKN20.68933063
34TAOK20.65681280
35ZAK0.64537397
36MAPK110.60467796
37CAMK40.58928815
38AKT20.52655676
39CAMK2G0.51851781
40MAP3K10.50363398
41EEF2K0.49534651
42TAOK10.47465226
43ILK0.46933964
44MAP3K110.45816332
45SIK10.45119422
46EPHB10.44897971
47CAMK10.41927692
48RIPK10.40653055
49PTK60.40615227
50CAMK2B0.38512053
51MAP3K60.37569709
52TBK10.34730433
53ERN10.32261998
54MST1R0.31997105
55TYK20.29310209
56MAP3K50.28879913
57TGFBR20.28826393
58SGK10.27583875
59SGK20.27484631
60PRKACB0.27175126
61LRRK20.27005679
62PKN10.26793876
63RPS6KB10.26639926
64INSRR0.26604342
65MAPK130.26540058
66MAP3K100.25617060
67LATS20.25557342
68LIMK10.25343908
69PRKD10.24136948
70TIE10.23229748
71PRKG10.22195488
72RPS6KA30.20866785
73PRPF4B0.20623861
74ROCK10.20324631
75CDK190.20053487
76MAPK70.19989412
77MAPK40.19876662
78PRKACA0.19712759
79DAPK20.19593212
80PDK10.16589132
81NME20.15951628
82ARAF0.15813614
83PDPK10.15000351
84MARK20.14891080
85MARK30.14755537
86RPS6KA10.13759252
87DYRK1B0.12702717
88MAP2K10.12633340
89RPS6KL10.12498397
90RPS6KC10.12498397
91ZAP700.12435363
92MOS0.11809365
93KSR20.11717925
94LATS10.11606632
95JAK20.10663905
96RPS6KA60.09491922
97SGK4940.08635658
98SGK2230.08635658
99CAMK1G0.08547115
100RPS6KA20.08385297
101RAF10.08291036
102CAMK2D0.08154957
103BRAF0.07322081
104TNK20.06700840
105PRKACG0.06292025
106FLT30.06049360
107RPS6KB20.04907632
108FER0.04846323
109STK110.03972046
110PAK60.03538802
111KSR10.03194504
112ROCK20.02515676
113MTOR0.02362537
114GSK3B0.02135003
115GRK70.02006929
116CSNK1D0.01917294
117MAPK30.01914387
118MAP2K20.01797091
119MAPK90.01226938
120FGFR10.00855577
121MAP3K90.00839291
122MAPK100.00344758
123FGFR30.00148013
124PTK2B-0.0295413
125ICK-0.0294630
126MAPKAPK2-0.0241713
127CAMK2A-0.0238191
128DYRK3-0.0229362
129SGK3-0.0124080
130MAPK8-0.0001191

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.41757464
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.20462621
3Cardiac muscle contraction_Homo sapiens_hsa042603.71438745
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.56870541
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.42855948
6Dilated cardiomyopathy_Homo sapiens_hsa054143.37813888
7Starch and sucrose metabolism_Homo sapiens_hsa005002.87757799
8Propanoate metabolism_Homo sapiens_hsa006402.60858349
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28946270
10Circadian rhythm_Homo sapiens_hsa047102.25853496
11Glucagon signaling pathway_Homo sapiens_hsa049222.25101502
12Carbon metabolism_Homo sapiens_hsa012002.20020731
13Insulin signaling pathway_Homo sapiens_hsa049102.11981121
14Insulin resistance_Homo sapiens_hsa049312.09573528
15Oxytocin signaling pathway_Homo sapiens_hsa049212.06752229
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.00256836
17Parkinsons disease_Homo sapiens_hsa050121.96126227
18Alzheimers disease_Homo sapiens_hsa050101.82085139
19Galactose metabolism_Homo sapiens_hsa000521.81509656
20Adipocytokine signaling pathway_Homo sapiens_hsa049201.79643572
21Oxidative phosphorylation_Homo sapiens_hsa001901.78590139
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76449272
23Fatty acid degradation_Homo sapiens_hsa000711.73500550
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64622914
25Calcium signaling pathway_Homo sapiens_hsa040201.63665144
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60993275
27Fructose and mannose metabolism_Homo sapiens_hsa000511.57661937
28AMPK signaling pathway_Homo sapiens_hsa041521.57310822
29Viral myocarditis_Homo sapiens_hsa054161.47761871
30Pyruvate metabolism_Homo sapiens_hsa006201.37363317
31Biosynthesis of amino acids_Homo sapiens_hsa012301.34772958
32Tight junction_Homo sapiens_hsa045301.19907860
33Arginine and proline metabolism_Homo sapiens_hsa003301.17082032
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16141430
35Fatty acid metabolism_Homo sapiens_hsa012121.15578054
36Nitrogen metabolism_Homo sapiens_hsa009101.15072378
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11333506
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.04235282
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02842972
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00938512
41Pentose phosphate pathway_Homo sapiens_hsa000301.00051198
42Focal adhesion_Homo sapiens_hsa045100.95781835
43GnRH signaling pathway_Homo sapiens_hsa049120.95315346
44Arginine biosynthesis_Homo sapiens_hsa002200.90018686
45Gastric acid secretion_Homo sapiens_hsa049710.88229230
46FoxO signaling pathway_Homo sapiens_hsa040680.86957326
47Huntingtons disease_Homo sapiens_hsa050160.85967418
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83669660
49Long-term potentiation_Homo sapiens_hsa047200.83498469
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.80217865
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75206603
52HIF-1 signaling pathway_Homo sapiens_hsa040660.68174294
53VEGF signaling pathway_Homo sapiens_hsa043700.67764402
54Renin secretion_Homo sapiens_hsa049240.64288993
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61456106
56Fatty acid biosynthesis_Homo sapiens_hsa000610.60260212
57mTOR signaling pathway_Homo sapiens_hsa041500.59987169
58MAPK signaling pathway_Homo sapiens_hsa040100.59211094
59PPAR signaling pathway_Homo sapiens_hsa033200.58847230
60beta-Alanine metabolism_Homo sapiens_hsa004100.54652836
61Platelet activation_Homo sapiens_hsa046110.53439722
62Amoebiasis_Homo sapiens_hsa051460.53306127
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.48077023
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45414352
65Sulfur metabolism_Homo sapiens_hsa009200.43281305
66Butanoate metabolism_Homo sapiens_hsa006500.42817175
67Circadian entrainment_Homo sapiens_hsa047130.40067392
68Sulfur relay system_Homo sapiens_hsa041220.37810733
69Type II diabetes mellitus_Homo sapiens_hsa049300.37312487
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35570339
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34445228
72Proteoglycans in cancer_Homo sapiens_hsa052050.34358282
73Salivary secretion_Homo sapiens_hsa049700.33156539
74Insulin secretion_Homo sapiens_hsa049110.32925995
75Adherens junction_Homo sapiens_hsa045200.32862080
76Phenylalanine metabolism_Homo sapiens_hsa003600.31228839
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29582754
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27359183
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26871435
80Fatty acid elongation_Homo sapiens_hsa000620.26797114
81Purine metabolism_Homo sapiens_hsa002300.26070127
82Peroxisome_Homo sapiens_hsa041460.25347129
83Histidine metabolism_Homo sapiens_hsa003400.25123190
84Regulation of autophagy_Homo sapiens_hsa041400.25017981
85ABC transporters_Homo sapiens_hsa020100.24780081
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22154137
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21748210
88Amphetamine addiction_Homo sapiens_hsa050310.21291683
89Linoleic acid metabolism_Homo sapiens_hsa005910.19882996
90Renal cell carcinoma_Homo sapiens_hsa052110.19162005
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19012303
92Glioma_Homo sapiens_hsa052140.18109007
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17289128
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16522423
95cAMP signaling pathway_Homo sapiens_hsa040240.16134419
96Prolactin signaling pathway_Homo sapiens_hsa049170.15323064
97ECM-receptor interaction_Homo sapiens_hsa045120.14135528
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13860578
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.13689868
100Metabolic pathways_Homo sapiens_hsa011000.12989937
101Thyroid cancer_Homo sapiens_hsa052160.11996212
102Tryptophan metabolism_Homo sapiens_hsa003800.11667499
103Long-term depression_Homo sapiens_hsa047300.11118384
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.10967316
105Pancreatic secretion_Homo sapiens_hsa049720.10509280
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.09969705
107Oocyte meiosis_Homo sapiens_hsa041140.09377181
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08908982
109Olfactory transduction_Homo sapiens_hsa047400.08109801
110Dorso-ventral axis formation_Homo sapiens_hsa043200.07133306
111Tyrosine metabolism_Homo sapiens_hsa003500.06148288
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.06141435
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05960080
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05946487
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04857249
116Melanogenesis_Homo sapiens_hsa049160.04224901
117Toxoplasmosis_Homo sapiens_hsa051450.04109369
118Lysine degradation_Homo sapiens_hsa003100.03792000
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.02938501
120Cholinergic synapse_Homo sapiens_hsa047250.02290637
121Acute myeloid leukemia_Homo sapiens_hsa052210.01684362

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