ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fucose catabolic process (GO:0019317)	9.30120786
2	L-fucose metabolic process (GO:0042354)	9.30120786
3	L-fucose catabolic process (GO:0042355)	9.30120786
4	vitamin transmembrane transport (GO:0035461)	8.01747010
5	pyrimidine-containing compound transmembrane transport (GO:0072531)	7.17588465
6	fucosylation (GO:0036065)	5.82872889
7	fucose metabolic process (GO:0006004)	5.31680527
8	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	5.08813493
9	ribosomal large subunit biogenesis (GO:0042273)	4.88662221
10	water-soluble vitamin biosynthetic process (GO:0042364)	4.73730867
11	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.44909646
12	cellular ketone body metabolic process (GO:0046950)	4.34773169
13	ubiquinone biosynthetic process (GO:0006744)	4.33221272
14	regulation of mesenchymal cell apoptotic process (GO:2001053)	4.29815676
15	negative regulation of telomere maintenance (GO:0032205)	4.28845540
16	cysteine metabolic process (GO:0006534)	4.26656246
17	DNA replication checkpoint (GO:0000076)	4.21892696
18	mitochondrial DNA replication (GO:0006264)	4.14288200
19	negative regulation of macroautophagy (GO:0016242)	3.99822599
20	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.99536929
21	mitochondrial RNA metabolic process (GO:0000959)	3.95694907
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.90348281
23	ubiquinone metabolic process (GO:0006743)	3.88757702
24	behavioral response to nicotine (GO:0035095)	3.87493721
25	ketone body metabolic process (GO:1902224)	3.86859988
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.80315187
27	NADH dehydrogenase complex assembly (GO:0010257)	3.80315187
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.80315187
29	respiratory chain complex IV assembly (GO:0008535)	3.77595412
30	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.70860129
31	primary amino compound metabolic process (GO:1901160)	3.67372246
32	inner mitochondrial membrane organization (GO:0007007)	3.57602719
33	response to growth hormone (GO:0060416)	3.55260291
34	pantothenate metabolic process (GO:0015939)	3.53496577
35	single strand break repair (GO:0000012)	3.51298118
36	serine family amino acid biosynthetic process (GO:0009070)	3.48933404
37	quinone biosynthetic process (GO:1901663)	3.48280585
38	azole transport (GO:0045117)	3.48092324
39	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.43769754
40	regulation of translation, ncRNA-mediated (GO:0045974)	3.43769754
41	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.43769754
42	protein import into peroxisome matrix (GO:0016558)	3.37211142
43	protein complex biogenesis (GO:0070271)	3.31761076
44	regulation of mitochondrial translation (GO:0070129)	3.25149884
45	white fat cell differentiation (GO:0050872)	3.23421242
46	tRNA methylation (GO:0030488)	3.21972343
47	ribosomal small subunit assembly (GO:0000028)	3.15260831
48	DNA-dependent DNA replication (GO:0006261)	3.10854214
49	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.07029189
50	piRNA metabolic process (GO:0034587)	3.06522823
51	cardiolipin metabolic process (GO:0032048)	3.06147736
52	synapsis (GO:0007129)	3.05261575
53	cAMP catabolic process (GO:0006198)	3.01179108
54	protein localization to cytoskeleton (GO:0044380)	3.01028777
55	somite development (GO:0061053)	3.00201528
56	kynurenine metabolic process (GO:0070189)	2.95514368
57	terpenoid biosynthetic process (GO:0016114)	2.91726858
58	autophagic vacuole fusion (GO:0000046)	2.91400062
59	tight junction assembly (GO:0070830)	2.90895088
60	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.90343714
61	cytochrome complex assembly (GO:0017004)	2.88810508
62	phosphatidylglycerol biosynthetic process (GO:0006655)	2.83574765
63	response to xenobiotic stimulus (GO:0009410)	2.82763681
64	oxidative demethylation (GO:0070989)	2.80558982
65	male meiosis (GO:0007140)	2.77973202
66	import into cell (GO:0098657)	2.77314961
67	protein localization to microtubule cytoskeleton (GO:0072698)	2.76154936
68	endosome to pigment granule transport (GO:0043485)	2.75295472
69	endosome to melanosome transport (GO:0035646)	2.75295472
70	meiotic chromosome segregation (GO:0045132)	2.73773358
71	pyrimidine dimer repair (GO:0006290)	2.73083151
72	nonmotile primary cilium assembly (GO:0035058)	2.72895934
73	intracellular protein transmembrane import (GO:0044743)	2.72771528
74	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.68520845
75	regulation of cellular senescence (GO:2000772)	2.66484175
76	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.65974958
77	cellular response to exogenous dsRNA (GO:0071360)	2.64748804
78	cyclic nucleotide catabolic process (GO:0009214)	2.64329313
79	response to testosterone (GO:0033574)	2.62620654
80	negative regulation of cardiac muscle hypertrophy (GO:0010614)	2.58821655
81	peristalsis (GO:0030432)	2.56825916
82	respiratory tube development (GO:0030323)	2.56729235
83	cellular response to cholesterol (GO:0071397)	2.56382141
84	spinal cord motor neuron differentiation (GO:0021522)	2.54318498
85	water-soluble vitamin metabolic process (GO:0006767)	2.54314959
86	sequestering of actin monomers (GO:0042989)	2.54149225
87	protein K11-linked deubiquitination (GO:0035871)	2.53895920
88	sulfur compound transport (GO:0072348)	2.53773532
89	polyamine biosynthetic process (GO:0006596)	2.53130662
90	organelle membrane fusion (GO:0090174)	2.53016933
91	histone-serine phosphorylation (GO:0035404)	2.51904939
92	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.51343314
93	cellular response to sterol (GO:0036315)	2.51069191
94	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.50228418
95	maturation of SSU-rRNA (GO:0030490)	2.49206399
96	vitamin transport (GO:0051180)	2.49193182
97	indole-containing compound catabolic process (GO:0042436)	2.48588150
98	indolalkylamine catabolic process (GO:0046218)	2.48588150
99	tryptophan catabolic process (GO:0006569)	2.48588150
100	nucleotide-excision repair, DNA damage removal (GO:0000718)	2.46876740

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	5.23019753
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.54898052
3	VDR_22108803_ChIP-Seq_LS180_Human	3.13841113
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.88792942
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.67086665
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.62319063
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.59604550
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.32404642
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25837375
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.24099407
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.16492658
12	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.08401323
13	IRF1_19129219_ChIP-ChIP_H3396_Human	2.01144650
14	TP53_16413492_ChIP-PET_HCT116_Human	1.99730822
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.98231730
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92015827
17	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.88046477
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.84544257
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.84333800
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.83622420
21	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.82221149
22	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.82221149
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78225525
24	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.77738300
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.73308263
26	P300_19829295_ChIP-Seq_ESCs_Human	1.68779839
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.67252298
28	ERA_21632823_ChIP-Seq_H3396_Human	1.64466079
29	EWS_26573619_Chip-Seq_HEK293_Human	1.63479799
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.62744048
31	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.58744224
32	SOX2_19829295_ChIP-Seq_ESCs_Human	1.54959672
33	NANOG_19829295_ChIP-Seq_ESCs_Human	1.54959672
34	TCF4_22108803_ChIP-Seq_LS180_Human	1.51378414
35	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.50850320
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.50105736
37	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.49646017
38	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.48355590
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.47757222
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46994871
41	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.42326679
42	DROSHA_22980978_ChIP-Seq_HELA_Human	1.39685525
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.36472524
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.35648530
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34462856
46	FUS_26573619_Chip-Seq_HEK293_Human	1.33000955
47	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.31551634
48	RBPJ_21746931_ChIP-Seq_IB4_Human	1.31304793
49	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.28579369
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.28310351
51	PHF8_20622853_ChIP-Seq_HELA_Human	1.26728895
52	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25744530
53	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.24511044
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24356629
55	FOXP3_21729870_ChIP-Seq_TREG_Human	1.22751403
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.21867786
57	AR_20517297_ChIP-Seq_VCAP_Human	1.21355288
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.20992053
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20440961
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19863813
61	P53_21459846_ChIP-Seq_SAOS-2_Human	1.18595050
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18302636
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17989881
64	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.17802415
65	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16198270
66	ETV1_20927104_ChIP-Seq_GIST48_Human	1.15685918
67	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.14709588
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14101628
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.13977505
70	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.13114082
71	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.12741170
72	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.12415542
73	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.11940602
74	NFYA_21822215_ChIP-Seq_K562_Human	1.11351402
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10538805
76	AHR_22903824_ChIP-Seq_MCF-7_Human	1.10509825
77	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.09732825
78	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.07665227
79	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06448093
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06448093
81	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04014060
82	ELK1_19687146_ChIP-ChIP_HELA_Human	1.03010706
83	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.02731453
84	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.02360651
85	TBL1_22424771_ChIP-Seq_293T_Human	1.01201355
86	CDX2_22108803_ChIP-Seq_LS180_Human	1.00988926
87	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.00622649
88	GATA4_25053715_ChIP-Seq_YYC3_Human	1.00496457
89	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00158090
90	GATA1_22025678_ChIP-Seq_K562_Human	0.98476675
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97478096
92	E2F7_22180533_ChIP-Seq_HELA_Human	0.96429244
93	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.95632754
94	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95429079
95	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.95287280
96	TCF4_23295773_ChIP-Seq_U87_Human	0.93297033
97	SMAD4_21799915_ChIP-Seq_A2780_Human	0.93034869
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.93014613
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.92440368
100	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.90988823

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.39552179
2	MP0008877_abnormal_DNA_methylation	4.60529672
3	MP0003806_abnormal_nucleotide_metabolis	4.00849919
4	MP0008875_abnormal_xenobiotic_pharmacok	3.41988089
5	MP0004885_abnormal_endolymph	3.40393880
6	MP0003136_yellow_coat_color	3.29212043
7	MP0009379_abnormal_foot_pigmentation	3.18465528
8	MP0003941_abnormal_skin_development	3.14378059
9	MP0009840_abnormal_foam_cell	3.08868931
10	MP0004742_abnormal_vestibular_system	2.87135682
11	MP0004043_abnormal_pH_regulation	2.59965716
12	MP0002277_abnormal_respiratory_mucosa	2.53761242
13	MP0002132_abnormal_respiratory_system	2.44526418
14	MP0003191_abnormal_cellular_cholesterol	2.43161269
15	MP0004142_abnormal_muscle_tone	2.38612293
16	MP0002876_abnormal_thyroid_physiology	2.37423760
17	MP0004147_increased_porphyrin_level	2.31670135
18	MP0003950_abnormal_plasma_membrane	1.96568216
19	MP0002163_abnormal_gland_morphology	1.91654488
20	MP0000372_irregular_coat_pigmentation	1.89399220
21	MP0003646_muscle_fatigue	1.87798833
22	MP0002102_abnormal_ear_morphology	1.82251862
23	MP0005670_abnormal_white_adipose	1.81143858
24	MP0002282_abnormal_trachea_morphology	1.74148807
25	MP0002837_dystrophic_cardiac_calcinosis	1.68013671
26	MP0008058_abnormal_DNA_repair	1.61337139
27	MP0008961_abnormal_basal_metabolism	1.55744847
28	MP0005551_abnormal_eye_electrophysiolog	1.50429122
29	MP0000427_abnormal_hair_cycle	1.47354539
30	MP0001485_abnormal_pinna_reflex	1.43434996
31	MP0000383_abnormal_hair_follicle	1.43032382
32	MP0001529_abnormal_vocalization	1.41638006
33	MP0005332_abnormal_amino_acid	1.41374199
34	MP0001984_abnormal_olfaction	1.36833447
35	MP0005085_abnormal_gallbladder_physiolo	1.28999030
36	MP0006035_abnormal_mitochondrial_morpho	1.27366756
37	MP0002938_white_spotting	1.25770517
38	MP0002138_abnormal_hepatobiliary_system	1.25672562
39	MP0005448_abnormal_energy_balance	1.22270090
40	MP0009745_abnormal_behavioral_response	1.20759308
41	MP0001501_abnormal_sleep_pattern	1.18496800
42	MP0005365_abnormal_bile_salt	1.14108790
43	MP0002638_abnormal_pupillary_reflex	1.11207063
44	MP0000647_abnormal_sebaceous_gland	1.11115980
45	MP0002653_abnormal_ependyma_morphology	1.09682275
46	MP0005310_abnormal_salivary_gland	1.07865784
47	MP0000026_abnormal_inner_ear	1.07809941
48	MP0003718_maternal_effect	1.05549882
49	MP0000631_abnormal_neuroendocrine_gland	1.05327240
50	MP0002098_abnormal_vibrissa_morphology	1.04104972
51	MP0004130_abnormal_muscle_cell	1.01789120
52	MP0009046_muscle_twitch	0.99927903
53	MP0005266_abnormal_metabolism	0.95432332
54	MP0004215_abnormal_myocardial_fiber	0.94711650
55	MP0003011_delayed_dark_adaptation	0.92985764
56	MP0008007_abnormal_cellular_replicative	0.91553064
57	MP0004381_abnormal_hair_follicle	0.87362704
58	MP0000049_abnormal_middle_ear	0.86382547
59	MP0002254_reproductive_system_inflammat	0.86115176
60	MP0004484_altered_response_of	0.84444769
61	MP0006036_abnormal_mitochondrial_physio	0.83689848
62	MP0002272_abnormal_nervous_system	0.83267906
63	MP0005379_endocrine/exocrine_gland_phen	0.81985332
64	MP0002734_abnormal_mechanical_nocicepti	0.81252019
65	MP0003567_abnormal_fetal_cardiomyocyte	0.79713204
66	MP0009115_abnormal_fat_cell	0.78615215
67	MP0003119_abnormal_digestive_system	0.78277852
68	MP0002557_abnormal_social/conspecific_i	0.78251993
69	MP0003693_abnormal_embryo_hatching	0.77906476
70	MP0001664_abnormal_digestion	0.77652095
71	MP0004782_abnormal_surfactant_physiolog	0.76477725
72	MP0000470_abnormal_stomach_morphology	0.74918904
73	MP0008057_abnormal_DNA_replication	0.73762628
74	MP0002933_joint_inflammation	0.73108036
75	MP0005408_hypopigmentation	0.71759786
76	MP0002572_abnormal_emotion/affect_behav	0.71683981
77	MP0005187_abnormal_penis_morphology	0.71002412
78	MP0002210_abnormal_sex_determination	0.70351741
79	MP0010329_abnormal_lipoprotein_level	0.70285585
80	MP0000371_diluted_coat_color	0.68489803
81	MP0001986_abnormal_taste_sensitivity	0.67523175
82	MP0009780_abnormal_chondrocyte_physiolo	0.67132640
83	MP0003137_abnormal_impulse_conducting	0.66818275
84	MP0002075_abnormal_coat/hair_pigmentati	0.65350229
85	MP0001764_abnormal_homeostasis	0.64825995
86	MP0005620_abnormal_muscle_contractility	0.63416062
87	MP0001440_abnormal_grooming_behavior	0.63405928
88	MP0005595_abnormal_vascular_smooth	0.61331660
89	MP0004924_abnormal_behavior	0.60457392
90	MP0005386_behavior/neurological_phenoty	0.60457392
91	MP0000516_abnormal_urinary_system	0.56949509
92	MP0005367_renal/urinary_system_phenotyp	0.56949509
93	MP0003959_abnormal_lean_body	0.56857380
94	MP0005165_increased_susceptibility_to	0.56008689
95	MP0002970_abnormal_white_adipose	0.54497563
96	MP0005195_abnormal_posterior_eye	0.54149949
97	MP0005334_abnormal_fat_pad	0.53790534
98	MP0009643_abnormal_urine_homeostasis	0.52731177
99	MP0002332_abnormal_exercise_endurance	0.51135659
100	MP0002269_muscular_atrophy	0.50445433

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mutism (HP:0002300)	6.04952598
2	Concave nail (HP:0001598)	4.99868168
3	Birth length less than 3rd percentile (HP:0003561)	4.74147813
4	Inability to walk (HP:0002540)	4.44851665
5	Confusion (HP:0001289)	4.24366459
6	Abnormality of the left ventricular outflow tract (HP:0011103)	4.16103380
7	Subaortic stenosis (HP:0001682)	4.16103380
8	External ophthalmoplegia (HP:0000544)	4.03209970
9	Abnormality of midbrain morphology (HP:0002418)	4.02352593
10	Molar tooth sign on MRI (HP:0002419)	4.02352593
11	Hypoplasia of the capital femoral epiphysis (HP:0003090)	3.89866596
12	Morphological abnormality of the middle ear (HP:0008609)	3.86912893
13	3-Methylglutaconic aciduria (HP:0003535)	3.80149481
14	Bile duct proliferation (HP:0001408)	3.45012181
15	Abnormal biliary tract physiology (HP:0012439)	3.45012181
16	Pancreatic cysts (HP:0001737)	3.40392399
17	True hermaphroditism (HP:0010459)	3.32124503
18	Congenital stationary night blindness (HP:0007642)	3.29749264
19	Pancreatic fibrosis (HP:0100732)	3.28333953
20	Reticulocytopenia (HP:0001896)	3.25538693
21	Irregular epiphyses (HP:0010582)	3.13559010
22	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	3.11042450
23	Absent epiphyses (HP:0010577)	3.11042450
24	Global brain atrophy (HP:0002283)	3.03900761
25	Morphological abnormality of the inner ear (HP:0011390)	3.02958865
26	Nephronophthisis (HP:0000090)	2.77880095
27	Morphological abnormality of the pyramidal tract (HP:0002062)	2.72650326
28	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.69120713
29	Central scotoma (HP:0000603)	2.65646338
30	Abnormal number of erythroid precursors (HP:0012131)	2.62520173
31	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.60823734
32	Congenital, generalized hypertrichosis (HP:0004540)	2.59943485
33	Paraparesis (HP:0002385)	2.59757576
34	Premature skin wrinkling (HP:0100678)	2.58634654
35	Progressive sensorineural hearing impairment (HP:0000408)	2.56918264
36	Bilateral microphthalmos (HP:0007633)	2.55339337
37	Furrowed tongue (HP:0000221)	2.51988946
38	Duplicated collecting system (HP:0000081)	2.46020094
39	Progressive inability to walk (HP:0002505)	2.44166504
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.44088798
41	Abnormality of alanine metabolism (HP:0010916)	2.44088798
42	Hyperalaninemia (HP:0003348)	2.44088798
43	Abnormality of the renal medulla (HP:0100957)	2.42737467
44	Cystic liver disease (HP:0006706)	2.34723963
45	Proximal tubulopathy (HP:0000114)	2.31630064
46	Abnormality of cells of the erythroid lineage (HP:0012130)	2.27728156
47	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.25032797
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.20130194
49	Facial diplegia (HP:0001349)	2.19926729
50	Hypoplastic labia majora (HP:0000059)	2.18312862
51	Sclerocornea (HP:0000647)	2.17624108
52	Tachypnea (HP:0002789)	2.17413877
53	Bicuspid aortic valve (HP:0001647)	2.17394517
54	Abnormal tarsal ossification (HP:0008369)	2.16633475
55	Brittle hair (HP:0002299)	2.15333823
56	Abnormality of macular pigmentation (HP:0008002)	2.14586008
57	Decreased central vision (HP:0007663)	2.14128894
58	Abnormality of the renal collecting system (HP:0004742)	2.13428266
59	Polymicrogyria (HP:0002126)	2.12899357
60	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.12275980
61	Tubular atrophy (HP:0000092)	2.10711447
62	Severe visual impairment (HP:0001141)	2.10402031
63	Slender long bone (HP:0003100)	2.10400754
64	Scotoma (HP:0000575)	2.08538355
65	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.06013970
66	Breast hypoplasia (HP:0003187)	2.04811352
67	Triphalangeal thumb (HP:0001199)	2.04290782
68	Partial agenesis of the corpus callosum (HP:0001338)	2.04152534
69	Optic nerve coloboma (HP:0000588)	2.02516510
70	Abnormality of the carotid arteries (HP:0005344)	1.99391998
71	Abnormality of the fovea (HP:0000493)	1.96733806
72	Hypoplasia of the fovea (HP:0007750)	1.96657452
73	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.96657452
74	Abnormality of DNA repair (HP:0003254)	1.95176351
75	Abnormality of the labia majora (HP:0012881)	1.94073453
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.93669839
77	Absent thumb (HP:0009777)	1.93333465
78	Abnormality of the renal cortex (HP:0011035)	1.92508919
79	Oligohydramnios (HP:0001562)	1.89374790
80	Sensory axonal neuropathy (HP:0003390)	1.89366808
81	Increased cerebral lipofuscin (HP:0011813)	1.88699237
82	Chronic hepatic failure (HP:0100626)	1.88219984
83	Abnormality of the vertebral endplates (HP:0005106)	1.87810507
84	Decreased subcutaneous fat (HP:0001002)	1.87469095
85	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.87079905
86	Myopathic facies (HP:0002058)	1.87030144
87	Pallor (HP:0000980)	1.85151392
88	Renovascular hypertension (HP:0100817)	1.84720424
89	Type II lissencephaly (HP:0007260)	1.84323485
90	Chromsome breakage (HP:0040012)	1.83018613
91	Amelogenesis imperfecta (HP:0000705)	1.82731012
92	Long foot (HP:0001833)	1.79172976
93	Small epiphyses (HP:0010585)	1.78826382
94	Anencephaly (HP:0002323)	1.78286075
95	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.78114197
96	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.76798931
97	Abnormality of the femoral head (HP:0003368)	1.75162470
98	Spastic tetraparesis (HP:0001285)	1.74368445
99	Short hallux (HP:0010109)	1.74258810
100	Progressive hearing impairment (HP:0001730)	1.74176498

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK24	7.39674669
2	STK38L	5.66266445
3	ADRBK2	3.86470928
4	FRK	3.16994760
5	NTRK3	2.87420319
6	INSRR	2.70308695
7	BMPR2	2.65184989
8	BCR	2.47827064
9	MAPKAPK3	2.34026034
10	WNK3	2.31404758
11	SIK3	2.19295413
12	BMPR1B	2.15135594
13	ACVR1B	2.02561570
14	STK3	1.88259473
15	MAP2K3	1.79070186
16	MAP2K6	1.77858411
17	WNK4	1.72469344
18	ERBB3	1.68927773
19	CASK	1.67745979
20	MAP3K6	1.63767190
21	PBK	1.53482248
22	TGFBR1	1.52786389
23	DAPK2	1.47231614
24	SIK2	1.39987899
25	KSR1	1.38116675
26	ADRBK1	1.27682110
27	MAP2K4	1.18508083
28	TRIM28	1.13094717
29	GRK1	1.12501783
30	PIK3CA	1.11218680
31	ZAK	1.09820268
32	EPHB2	1.02850081
33	ABL2	1.00447412
34	NME1	0.99091412
35	ZAP70	0.96753156
36	MAPK13	0.94834337
37	MAP2K1	0.90332970
38	MKNK2	0.90015044
39	BRD4	0.89004442
40	KSR2	0.81772191
41	MAP3K2	0.75943752
42	DYRK2	0.69464636
43	RAF1	0.68827530
44	PKN1	0.65452128
45	MET	0.60075359
46	TNIK	0.58632293
47	MKNK1	0.58392036
48	TAF1	0.56271802
49	MAP3K5	0.55028460
50	PINK1	0.54115557
51	MINK1	0.51507931
52	CSNK1G1	0.50007761
53	CSNK1A1L	0.47472062
54	OXSR1	0.45714407
55	CDK4	0.44776021
56	CSNK1G3	0.43969717
57	IKBKB	0.43118325
58	CDK19	0.42881627
59	BUB1	0.41865768
60	PRKD3	0.41637007
61	PRKCE	0.40615380
62	TLK1	0.39802357
63	RET	0.39358846
64	MARK3	0.36672642
65	PAK6	0.36557689
66	BCKDK	0.36383905
67	NUAK1	0.36377010
68	PAK3	0.36016028
69	AKT2	0.35415417
70	IKBKE	0.35203521
71	CSNK1G2	0.34677012
72	STK11	0.33592168
73	CAMK2A	0.32655472
74	PTK2B	0.31427486
75	BLK	0.30598691
76	MAPKAPK5	0.29388355
77	MAP3K11	0.28903671
78	PLK4	0.28069041
79	PIK3CG	0.26171457
80	KIT	0.25645696
81	CAMK1	0.23622179
82	TSSK6	0.22820816
83	TEC	0.22325169
84	VRK2	0.22082795
85	WEE1	0.21943800
86	PTK2	0.21928510
87	CSNK1A1	0.21358666
88	PRKACA	0.20451132
89	CHEK2	0.20147394
90	RPS6KA6	0.19461102
91	WNK1	0.19191261
92	MAP3K9	0.18471566
93	CDK9	0.18282751
94	PRKCQ	0.17492549
95	MAP3K12	0.16712471
96	PRKCD	0.16555881
97	CSNK1D	0.16470562
98	RPS6KA5	0.15656670
99	PASK	0.15446576
100	MARK1	0.14725122

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.74699617
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.24388496
3	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.10824704
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.04834314
5	Butanoate metabolism_Homo sapiens_hsa00650	2.88103485
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.85935221
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.78538525
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.75871202
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.74180637
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.38671857
11	Folate biosynthesis_Homo sapiens_hsa00790	2.38305362
12	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	2.32472414
13	Ribosome_Homo sapiens_hsa03010	2.23890875
14	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.18863794
15	One carbon pool by folate_Homo sapiens_hsa00670	1.93260179
16	Basal transcription factors_Homo sapiens_hsa03022	1.82673344
17	Caffeine metabolism_Homo sapiens_hsa00232	1.80475807
18	Propanoate metabolism_Homo sapiens_hsa00640	1.76303698
19	Protein export_Homo sapiens_hsa03060	1.73834174
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.69363787
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69361931
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.57901872
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.39834057
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.39647441
25	ABC transporters_Homo sapiens_hsa02010	1.37495721
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.36107226
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.31368281
28	Homologous recombination_Homo sapiens_hsa03440	1.30582226
29	Legionellosis_Homo sapiens_hsa05134	1.26604993
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.24399120
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24386234
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24126347
33	Sulfur relay system_Homo sapiens_hsa04122	1.22271399
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18033774
35	Arginine and proline metabolism_Homo sapiens_hsa00330	1.16117365
36	Nicotine addiction_Homo sapiens_hsa05033	1.15483815
37	RNA polymerase_Homo sapiens_hsa03020	1.10774139
38	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.04822065
39	TNF signaling pathway_Homo sapiens_hsa04668	1.04752142
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03066820
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.02355486
42	Rheumatoid arthritis_Homo sapiens_hsa05323	1.01915112
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.01718620
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.01058182
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98964773
46	Sulfur metabolism_Homo sapiens_hsa00920	0.96926530
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93727716
48	Proteasome_Homo sapiens_hsa03050	0.92922043
49	Glutathione metabolism_Homo sapiens_hsa00480	0.90857320
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90606923
51	Peroxisome_Homo sapiens_hsa04146	0.90570320
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.90095044
53	Parkinsons disease_Homo sapiens_hsa05012	0.88507647
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86921502
55	Alzheimers disease_Homo sapiens_hsa05010	0.86180259
56	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.85797013
57	Histidine metabolism_Homo sapiens_hsa00340	0.85214624
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85088292
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.82307180
60	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.81893933
61	Morphine addiction_Homo sapiens_hsa05032	0.81811285
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79013252
63	Huntingtons disease_Homo sapiens_hsa05016	0.77702364
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74762387
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71342201
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66120260
67	Mineral absorption_Homo sapiens_hsa04978	0.64925961
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64555112
69	Purine metabolism_Homo sapiens_hsa00230	0.64539125
70	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.64257346
71	Tight junction_Homo sapiens_hsa04530	0.64089069
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62834640
73	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61586836
74	p53 signaling pathway_Homo sapiens_hsa04115	0.61089186
75	Retinol metabolism_Homo sapiens_hsa00830	0.58966939
76	Metabolic pathways_Homo sapiens_hsa01100	0.57392258
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.56427686
78	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.54102921
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53634668
80	Taste transduction_Homo sapiens_hsa04742	0.49037250
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45565337
82	Regulation of autophagy_Homo sapiens_hsa04140	0.45209799
83	Cardiac muscle contraction_Homo sapiens_hsa04260	0.44170919
84	RNA degradation_Homo sapiens_hsa03018	0.43458035
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42834385
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.42396528
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40187404
88	Phototransduction_Homo sapiens_hsa04744	0.39341665
89	Olfactory transduction_Homo sapiens_hsa04740	0.38325164
90	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.33018633
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32966948
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31088810
93	Serotonergic synapse_Homo sapiens_hsa04726	0.30872105
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30013767
95	PPAR signaling pathway_Homo sapiens_hsa03320	0.29906551
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.27912836
97	Insulin secretion_Homo sapiens_hsa04911	0.27293279
98	Steroid biosynthesis_Homo sapiens_hsa00100	0.26777667
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.25278466
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.25220444

TMPOP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »