TMPOP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)8.27693629
2DNA synthesis involved in DNA repair (GO:0000731)6.43182518
3chromosome organization involved in meiosis (GO:0070192)5.87522947
4mitotic sister chromatid cohesion (GO:0007064)5.34442864
5piRNA metabolic process (GO:0034587)5.16823689
6regulation of centriole replication (GO:0046599)5.14171065
7male meiosis I (GO:0007141)4.91602872
8chromatin remodeling at centromere (GO:0031055)4.88297762
9CENP-A containing nucleosome assembly (GO:0034080)4.80271024
10male meiosis (GO:0007140)4.79677196
11DNA methylation involved in gamete generation (GO:0043046)4.67955230
12histone exchange (GO:0043486)4.44321765
13mitotic sister chromatid segregation (GO:0000070)4.35058396
14synaptonemal complex assembly (GO:0007130)4.32440263
15DNA replication checkpoint (GO:0000076)4.30924109
16meiosis I (GO:0007127)4.29165262
17regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.22674184
18regulation of mitotic spindle checkpoint (GO:1903504)4.22674184
19meiotic nuclear division (GO:0007126)4.15135784
20DNA replication-dependent nucleosome organization (GO:0034723)4.14658019
21DNA replication-dependent nucleosome assembly (GO:0006335)4.14658019
22regulation of DNA endoreduplication (GO:0032875)4.14075135
23sister chromatid segregation (GO:0000819)4.11765197
24rRNA modification (GO:0000154)4.10004652
25DNA strand elongation involved in DNA replication (GO:0006271)4.08307008
26mitotic chromosome condensation (GO:0007076)4.08011308
27sister chromatid cohesion (GO:0007062)4.05823371
28kinetochore organization (GO:0051383)4.02392107
29DNA strand elongation (GO:0022616)3.91175203
30telomere maintenance via semi-conservative replication (GO:0032201)3.90069709
31protein localization to kinetochore (GO:0034501)3.88824851
32synaptonemal complex organization (GO:0070193)3.85062942
33rRNA methylation (GO:0031167)3.83577564
34nuclear pore complex assembly (GO:0051292)3.80671156
35regulation of centrosome cycle (GO:0046605)3.80375454
36DNA replication-independent nucleosome organization (GO:0034724)3.79934412
37DNA replication-independent nucleosome assembly (GO:0006336)3.79934412
38protein localization to chromosome, centromeric region (GO:0071459)3.78212200
39reciprocal meiotic recombination (GO:0007131)3.72436128
40reciprocal DNA recombination (GO:0035825)3.72436128
41regulation of centrosome duplication (GO:0010824)3.71149446
42negative regulation of DNA repair (GO:0045738)3.70193527
43meiotic cell cycle process (GO:1903046)3.67167659
44protein localization to chromosome (GO:0034502)3.65441325
45DNA unwinding involved in DNA replication (GO:0006268)3.65269145
46centriole replication (GO:0007099)3.64411533
47DNA double-strand break processing (GO:0000729)3.61134062
48spermatid nucleus differentiation (GO:0007289)3.60809952
49DNA catabolic process, exonucleolytic (GO:0000738)3.53877963
50positive regulation of DNA-dependent DNA replication (GO:2000105)3.53198162
51meiotic chromosome segregation (GO:0045132)3.51068816
52mitotic metaphase plate congression (GO:0007080)3.48763873
53spindle assembly involved in mitosis (GO:0090307)3.44333211
54telomere maintenance via recombination (GO:0000722)3.43387420
55regulation of spindle checkpoint (GO:0090231)3.40345152
56replication fork processing (GO:0031297)3.39923436
57metaphase plate congression (GO:0051310)3.39386439
58attachment of spindle microtubules to kinetochore (GO:0008608)3.37634077
59negative regulation of chromosome segregation (GO:0051985)3.32759257
60DNA ligation (GO:0006266)3.31737443
61resolution of meiotic recombination intermediates (GO:0000712)3.31541295
62mitotic recombination (GO:0006312)3.30275408
63microtubule depolymerization (GO:0007019)3.30194804
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28777405
65negative regulation of mitotic sister chromatid separation (GO:2000816)3.25429584
66negative regulation of sister chromatid segregation (GO:0033046)3.25429584
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.25429584
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25429584
69negative regulation of mitotic sister chromatid segregation (GO:0033048)3.25429584
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24508366
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24508366
72mannosylation (GO:0097502)3.23687946
73DNA replication initiation (GO:0006270)3.23618564
74mitotic spindle checkpoint (GO:0071174)3.22281610
75kinetochore assembly (GO:0051382)3.22045543
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.18855739
77DNA packaging (GO:0006323)3.18087863
78spindle checkpoint (GO:0031577)3.16276567
79nuclear pore organization (GO:0006999)3.14560223
80mitotic spindle assembly checkpoint (GO:0007094)3.13618662
81protein K6-linked ubiquitination (GO:0085020)3.10658247
82spindle assembly checkpoint (GO:0071173)3.10377225
83chromosome organization (GO:0051276)3.09497725
84histone H2A acetylation (GO:0043968)3.09428887
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.08112662
86regulation of sister chromatid segregation (GO:0033045)3.07008013
87regulation of mitotic sister chromatid separation (GO:0010965)3.07008013
88regulation of mitotic sister chromatid segregation (GO:0033047)3.07008013
89DNA biosynthetic process (GO:0071897)3.04809773
90DNA strand renaturation (GO:0000733)3.04481704
91regulation of chromosome segregation (GO:0051983)3.04075870
92proteasome assembly (GO:0043248)3.01148250
93cellular ketone body metabolic process (GO:0046950)2.97905207
94ATP-dependent chromatin remodeling (GO:0043044)2.95572163
95chromosome condensation (GO:0030261)2.95341713
96regulation of DNA-dependent DNA replication (GO:0090329)2.92132852
97chromosome segregation (GO:0007059)2.90948987
98microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.90288956
99regulation of sister chromatid cohesion (GO:0007063)2.90097078
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87490522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.94131497
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.97372485
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.59420364
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08313499
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.86718971
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.77511058
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.60898986
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.53632524
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.40661649
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09853344
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.91736940
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.85791394
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70754025
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66653063
15ELK1_19687146_ChIP-ChIP_HELA_Human2.54379353
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53206486
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44764383
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.40556355
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.39144258
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.35477922
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34421617
22XRN2_22483619_ChIP-Seq_HELA_Human2.26067187
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21772490
24VDR_23849224_ChIP-Seq_CD4+_Human2.21025542
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18501715
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16270001
27DCP1A_22483619_ChIP-Seq_HELA_Human2.06815439
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01509860
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99593336
30FOXP3_21729870_ChIP-Seq_TREG_Human1.98323009
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98122624
32TTF2_22483619_ChIP-Seq_HELA_Human1.96583471
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92234853
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91865650
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90477828
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89385334
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84340722
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80367953
39ZNF274_21170338_ChIP-Seq_K562_Hela1.77371234
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72535530
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70640662
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67582685
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67547934
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63601461
45MYC_18940864_ChIP-ChIP_HL60_Human1.61131869
46GABP_19822575_ChIP-Seq_HepG2_Human1.59283368
47AR_21909140_ChIP-Seq_LNCAP_Human1.54700346
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51282282
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48860429
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.45610990
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43645556
52EWS_26573619_Chip-Seq_HEK293_Human1.41578870
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38683776
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33851041
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29436225
56CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26858331
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25538007
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22494816
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.19103585
60FUS_26573619_Chip-Seq_HEK293_Human1.14391976
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13711978
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13258695
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.10897085
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10556096
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.09214244
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08699947
67KDM5A_27292631_Chip-Seq_BREAST_Human1.08528869
68SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08181867
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06827797
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04835345
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96772298
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95585506
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94858832
74SOX17_20123909_ChIP-Seq_XEN_Mouse0.94293078
75TP63_19390658_ChIP-ChIP_HaCaT_Human0.88905560
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88855219
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87965442
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87557184
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86291240
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84212100
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83013047
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80556636
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78825897
84TFEB_21752829_ChIP-Seq_HELA_Human0.77444912
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77086008
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76498737
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.74624620
88RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73079150
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70897046
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.69430508
91TP53_22573176_ChIP-Seq_HFKS_Human0.66993340
92RNF2_27304074_Chip-Seq_NSC_Mouse0.65545183
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.64912676
94TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64419006
95FOXP1_21924763_ChIP-Seq_HESCs_Human0.64193995
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.61185238
97VDR_22108803_ChIP-Seq_LS180_Human0.60419239
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.56860117
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.56282190
100E2F1_17053090_ChIP-ChIP_MCF-7_Human0.55326548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.47123465
2MP0010094_abnormal_chromosome_stability4.41802491
3MP0008058_abnormal_DNA_repair3.68239692
4MP0003111_abnormal_nucleus_morphology3.53658680
5MP0004957_abnormal_blastocyst_morpholog3.51018995
6MP0008877_abnormal_DNA_methylation3.09752145
7MP0003693_abnormal_embryo_hatching3.00368271
8MP0003077_abnormal_cell_cycle2.72798906
9MP0000579_abnormal_nail_morphology2.54212269
10MP0002210_abnormal_sex_determination2.43205484
11MP0008007_abnormal_cellular_replicative2.40746473
12MP0010030_abnormal_orbit_morphology2.35440030
13MP0002160_abnormal_reproductive_system2.30822013
14MP0001929_abnormal_gametogenesis2.29624367
15MP0000566_synostosis2.24981972
16MP0000537_abnormal_urethra_morphology2.18819050
17MP0000383_abnormal_hair_follicle2.15563686
18MP0003136_yellow_coat_color2.15509276
19MP0008932_abnormal_embryonic_tissue2.14972529
20MP0003718_maternal_effect2.04699928
21MP0003011_delayed_dark_adaptation1.95593720
22MP0001145_abnormal_male_reproductive1.94003162
23MP0005171_absent_coat_pigmentation1.87066594
24MP0003890_abnormal_embryonic-extraembry1.80648520
25MP0000653_abnormal_sex_gland1.78724953
26MP0003698_abnormal_male_reproductive1.74930915
27MP0002095_abnormal_skin_pigmentation1.71482995
28MP0000015_abnormal_ear_pigmentation1.68211434
29MP0001661_extended_life_span1.67489169
30MP0003786_premature_aging1.64316415
31MP0000427_abnormal_hair_cycle1.60790800
32MP0003806_abnormal_nucleotide_metabolis1.57554952
33MP0001697_abnormal_embryo_size1.48310963
34MP0006292_abnormal_olfactory_placode1.44847742
35MP0003941_abnormal_skin_development1.44654639
36MP0002396_abnormal_hematopoietic_system1.44224620
37MP0001346_abnormal_lacrimal_gland1.41917438
38MP0005410_abnormal_fertilization1.41370174
39MP0005174_abnormal_tail_pigmentation1.38734049
40MP0001293_anophthalmia1.36997220
41MP0001730_embryonic_growth_arrest1.33315274
42MP0010307_abnormal_tumor_latency1.30736397
43MP0005380_embryogenesis_phenotype1.29694060
44MP0001672_abnormal_embryogenesis/_devel1.29694060
45MP0000350_abnormal_cell_proliferation1.28661306
46MP0005367_renal/urinary_system_phenotyp1.27257339
47MP0000516_abnormal_urinary_system1.27257339
48MP0010678_abnormal_skin_adnexa1.25004370
49MP0000647_abnormal_sebaceous_gland1.24658274
50MP0002084_abnormal_developmental_patter1.21960527
51MP0005389_reproductive_system_phenotype1.20966181
52MP0003123_paternal_imprinting1.20394896
53MP0005076_abnormal_cell_differentiation1.19759210
54MP0000358_abnormal_cell_content/1.16704937
55MP0001119_abnormal_female_reproductive1.15151527
56MP0002080_prenatal_lethality1.13764030
57MP0003119_abnormal_digestive_system1.12490721
58MP0002085_abnormal_embryonic_tissue1.11637414
59MP0003950_abnormal_plasma_membrane1.10992796
60MP0000490_abnormal_crypts_of1.09810665
61MP0001188_hyperpigmentation1.09209694
62MP0002161_abnormal_fertility/fecundity1.08518258
63MP0003984_embryonic_growth_retardation1.06312375
64MP0003937_abnormal_limbs/digits/tail_de1.03177475
65MP0004197_abnormal_fetal_growth/weight/1.02844709
66MP0009379_abnormal_foot_pigmentation1.01918885
67MP0001286_abnormal_eye_development1.01108042
68MP0002088_abnormal_embryonic_growth/wei1.00933505
69MP0000313_abnormal_cell_death1.00595024
70MP0000462_abnormal_digestive_system0.98805532
71MP0005409_darkened_coat_color0.98738297
72MP0009250_abnormal_appendicular_skeleto0.97265926
73MP0002938_white_spotting0.96996774
74MP0001324_abnormal_eye_pigmentation0.95821546
75MP0009697_abnormal_copulation0.92103225
76MP0002282_abnormal_trachea_morphology0.90618845
77MP0003567_abnormal_fetal_cardiomyocyte0.89223671
78MP0003699_abnormal_female_reproductive0.88718212
79MP0003121_genomic_imprinting0.87027115
80MP0002233_abnormal_nose_morphology0.86030769
81MP0002098_abnormal_vibrissa_morphology0.85711950
82MP0002111_abnormal_tail_morphology0.81694480
83MP0005408_hypopigmentation0.79634477
84MP0003283_abnormal_digestive_organ0.77038721
85MP0006035_abnormal_mitochondrial_morpho0.77027179
86MP0002697_abnormal_eye_size0.76166931
87MP0009703_decreased_birth_body0.72426427
88MP0003315_abnormal_perineum_morphology0.71643123
89MP0002086_abnormal_extraembryonic_tissu0.70956691
90MP0002019_abnormal_tumor_incidence0.70252869
91MP0003755_abnormal_palate_morphology0.70212377
92MP0008995_early_reproductive_senescence0.69534290
93MP0003186_abnormal_redox_activity0.67961760
94MP0009672_abnormal_birth_weight0.64772840
95MP0000534_abnormal_ureter_morphology0.64270574
96MP0005391_vision/eye_phenotype0.62079594
97MP0005253_abnormal_eye_physiology0.61773979
98MP0004808_abnormal_hematopoietic_stem0.60959496
99MP0003656_abnormal_erythrocyte_physiolo0.60537903
100MP0002638_abnormal_pupillary_reflex0.58549619

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.29157467
2Oligodactyly (hands) (HP:0001180)4.18297495
3Volvulus (HP:0002580)4.15749197
4Abnormality of the labia minora (HP:0012880)4.01688423
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.93263728
6Chromsome breakage (HP:0040012)3.92142987
7Abnormality of the preputium (HP:0100587)3.71091859
8Birth length less than 3rd percentile (HP:0003561)3.62964038
9Meckel diverticulum (HP:0002245)3.59713119
10Type II lissencephaly (HP:0007260)3.59134118
11Abnormality of the ileum (HP:0001549)3.45534770
12Small intestinal stenosis (HP:0012848)3.44494186
13Duodenal stenosis (HP:0100867)3.44494186
14Abnormality of chromosome stability (HP:0003220)3.38178549
15Hypoplastic pelvis (HP:0008839)3.31855783
16Stenosis of the external auditory canal (HP:0000402)3.26706260
17Abnormality of the labia majora (HP:0012881)3.16813868
18Facial hemangioma (HP:0000329)3.16652610
19Dyschromatopsia (HP:0007641)3.10559881
20Reticulocytopenia (HP:0001896)3.10191649
21Hypoplastic labia majora (HP:0000059)3.09468773
22Oligodactyly (HP:0012165)3.06563388
23Ectopic kidney (HP:0000086)3.02314717
24Absent forearm bone (HP:0003953)2.92299735
25Aplasia involving forearm bones (HP:0009822)2.92299735
26Absent radius (HP:0003974)2.90265242
27Abnormal lung lobation (HP:0002101)2.88722138
28Myelodysplasia (HP:0002863)2.84117977
29Abnormality of the duodenum (HP:0002246)2.61316504
30Small hand (HP:0200055)2.60610102
31Duplication of thumb phalanx (HP:0009942)2.58160584
32Retinal dysplasia (HP:0007973)2.54544238
33Type I transferrin isoform profile (HP:0003642)2.52718737
34Triphalangeal thumb (HP:0001199)2.52577073
35Horseshoe kidney (HP:0000085)2.48504652
36Hypoplasia of the radius (HP:0002984)2.42638796
37Cerebellar dysplasia (HP:0007033)2.42156827
38Broad distal phalanx of finger (HP:0009836)2.40769942
39Clubbing of toes (HP:0100760)2.39638978
40Aplasia/Hypoplasia of the sternum (HP:0006714)2.38245407
41Duplicated collecting system (HP:0000081)2.37782550
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36531774
43Sloping forehead (HP:0000340)2.35943303
44Absent thumb (HP:0009777)2.34970827
45Hypoplastic female external genitalia (HP:0012815)2.30239332
46Congenital, generalized hypertrichosis (HP:0004540)2.27732723
47Bifid tongue (HP:0010297)2.25175646
48Increased nuchal translucency (HP:0010880)2.25003799
49Rimmed vacuoles (HP:0003805)2.20064749
50Abnormal spermatogenesis (HP:0008669)2.18535273
51Megaloblastic anemia (HP:0001889)2.16947580
52Shoulder girdle muscle weakness (HP:0003547)2.15309780
53Nephroblastoma (Wilms tumor) (HP:0002667)2.07057508
54Short tibia (HP:0005736)2.06801985
55Buphthalmos (HP:0000557)2.05325646
56Embryonal renal neoplasm (HP:0011794)2.03924493
57Abnormality of the pons (HP:0007361)2.02814216
58Rectovaginal fistula (HP:0000143)2.02753330
59Rectal fistula (HP:0100590)2.02753330
60Labial hypoplasia (HP:0000066)2.02235513
61Choanal atresia (HP:0000453)2.02155049
62Abnormality of the carotid arteries (HP:0005344)2.01255135
63Abnormality of the labia (HP:0000058)1.99972759
64Fused cervical vertebrae (HP:0002949)1.97246899
65Abnormality of glycolysis (HP:0004366)1.95817670
66Abnormality of methionine metabolism (HP:0010901)1.95400286
67Azoospermia (HP:0000027)1.95394775
68Abnormal protein glycosylation (HP:0012346)1.93747832
69Abnormal glycosylation (HP:0012345)1.93747832
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93747832
71Abnormal protein N-linked glycosylation (HP:0012347)1.93747832
72Patellar aplasia (HP:0006443)1.93634147
73Abnormality of the renal collecting system (HP:0004742)1.92864045
74Partial duplication of thumb phalanx (HP:0009944)1.90561567
75Anteriorly placed anus (HP:0001545)1.89729225
76Oral leukoplakia (HP:0002745)1.87337838
77Clitoromegaly (HP:0000057)1.84124588
78Aplasia/Hypoplasia of the patella (HP:0006498)1.82286349
79Abnormal gallbladder physiology (HP:0012438)1.81969543
80Cholecystitis (HP:0001082)1.81969543
81Macrocytic anemia (HP:0001972)1.81754565
82Atresia of the external auditory canal (HP:0000413)1.79604206
83Acanthocytosis (HP:0001927)1.79488179
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.78263870
85Hypoplasia of the pons (HP:0012110)1.76940168
86Split foot (HP:0001839)1.76856849
87Hepatocellular necrosis (HP:0001404)1.74504023
88Postnatal microcephaly (HP:0005484)1.73205667
89Rough bone trabeculation (HP:0100670)1.73031164
90Ureteral duplication (HP:0000073)1.72467414
91Absent septum pellucidum (HP:0001331)1.72393103
92Hypobetalipoproteinemia (HP:0003563)1.71747654
93Lissencephaly (HP:0001339)1.70093589
94Non-midline cleft lip (HP:0100335)1.69096495
95Molar tooth sign on MRI (HP:0002419)1.68967535
96Abnormality of midbrain morphology (HP:0002418)1.68967535
97Absent speech (HP:0001344)1.68397953
98Short thumb (HP:0009778)1.68166384
99Homocystinuria (HP:0002156)1.65979272
100Abnormality of homocysteine metabolism (HP:0010919)1.65979272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.37503360
2ZAK4.24190718
3PNCK3.99288269
4WEE13.74972400
5TLK12.90934362
6TTK2.66362306
7PDK22.64959950
8PLK42.46597385
9TSSK62.39888314
10CDC72.33659945
11STK162.22330816
12EIF2AK12.15367064
13PLK32.14774576
14ATR2.12089242
15VRK12.07953159
16NUAK12.06367327
17SRPK11.97813870
18PLK11.91968351
19TESK21.83422848
20NEK21.80675561
21BRSK21.76691685
22STK391.75930775
23PBK1.75789989
24FGFR21.73521986
25OXSR11.71877931
26VRK21.66829169
27PASK1.63476127
28STK38L1.55394718
29NEK11.41457068
30MKNK21.36689570
31CHEK21.36085271
32ACVR1B1.31678195
33MKNK11.25910479
34CHEK11.20961659
35PLK21.18833674
36AURKB1.16446985
37WNK41.14036868
38TAF11.09892068
39BRSK11.06745192
40SMG11.05343316
41TRIM281.03015291
42FGFR11.01569399
43MELK0.99098421
44STK30.95828471
45BRD40.94533801
46ATM0.89461645
47AURKA0.88616143
48BMPR1B0.85435265
49EIF2AK30.85222571
50MET0.83043020
51CCNB10.82648904
52CDK80.82158622
53WNK30.79687074
54RPS6KA50.76796907
55NME20.69744306
56TGFBR10.66924778
57CDK30.63761256
58CDK70.61201234
59RPS6KA40.60973800
60CSNK1E0.60747067
61CDK20.59589880
62CDK10.58983559
63BMX0.57746355
64MAPK150.55955046
65CAMK1G0.55204456
66CDK190.54015700
67MST1R0.53853514
68CDK90.50924617
69CSNK2A20.50861541
70CDK40.49828412
71ERBB40.45291243
72EIF2AK20.45205683
73STK40.44329452
74MST40.43454838
75ERBB30.43383802
76DYRK30.42896194
77CSNK2A10.42817202
78MARK30.38520529
79CDK60.38416287
80EPHA40.37765499
81PRKDC0.36688445
82SCYL20.36391779
83LATS20.35139051
84NME10.33734645
85MAP3K80.32579105
86MAP4K20.32442162
87MAPKAPK50.29883952
88RPS6KB20.29753862
89MAP2K70.29462428
90CLK10.27840227
91FLT30.27472305
92MAPK130.27149259
93AKT20.22904315
94MAPK140.22564257
95TAOK30.21324653
96PAK10.20370829
97PRKCH0.19955551
98PRKACB0.19380396
99RPS6KB10.18986877
100CASK0.18419403

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.27119543
2Mismatch repair_Homo sapiens_hsa034303.97587685
3Fanconi anemia pathway_Homo sapiens_hsa034603.15801555
4Homologous recombination_Homo sapiens_hsa034403.02541822
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.99068388
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98625358
7Proteasome_Homo sapiens_hsa030502.93492657
8Cell cycle_Homo sapiens_hsa041102.72673981
9Base excision repair_Homo sapiens_hsa034102.68095694
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.60202733
11RNA transport_Homo sapiens_hsa030132.46540576
12Non-homologous end-joining_Homo sapiens_hsa034502.45338843
13Protein export_Homo sapiens_hsa030602.36827187
14RNA polymerase_Homo sapiens_hsa030202.34372647
15Selenocompound metabolism_Homo sapiens_hsa004502.31450572
16Ribosome_Homo sapiens_hsa030102.12750826
17Nucleotide excision repair_Homo sapiens_hsa034202.05789849
18One carbon pool by folate_Homo sapiens_hsa006701.98730871
19Spliceosome_Homo sapiens_hsa030401.95776955
20Basal transcription factors_Homo sapiens_hsa030221.79619307
21mRNA surveillance pathway_Homo sapiens_hsa030151.79480788
22Pyrimidine metabolism_Homo sapiens_hsa002401.64819121
23Vitamin digestion and absorption_Homo sapiens_hsa049771.54994269
24Parkinsons disease_Homo sapiens_hsa050121.49737431
25Systemic lupus erythematosus_Homo sapiens_hsa053221.49566274
26Oxidative phosphorylation_Homo sapiens_hsa001901.49204199
27RNA degradation_Homo sapiens_hsa030181.47762611
28Propanoate metabolism_Homo sapiens_hsa006401.45060170
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44941840
30Huntingtons disease_Homo sapiens_hsa050161.44917942
31Pentose phosphate pathway_Homo sapiens_hsa000301.41911292
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40521608
33p53 signaling pathway_Homo sapiens_hsa041151.37316565
34Oocyte meiosis_Homo sapiens_hsa041141.29152255
35Fatty acid elongation_Homo sapiens_hsa000621.24484111
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23688745
37Glutathione metabolism_Homo sapiens_hsa004801.20517563
38N-Glycan biosynthesis_Homo sapiens_hsa005101.17061596
39Purine metabolism_Homo sapiens_hsa002301.03383732
40Carbon metabolism_Homo sapiens_hsa012001.03092326
41Biosynthesis of amino acids_Homo sapiens_hsa012301.03041312
42Alcoholism_Homo sapiens_hsa050341.02301359
43Butanoate metabolism_Homo sapiens_hsa006501.01977366
44Tryptophan metabolism_Homo sapiens_hsa003800.99468570
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.94565260
46Pyruvate metabolism_Homo sapiens_hsa006200.93518206
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93077333
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87144777
49Sulfur metabolism_Homo sapiens_hsa009200.84547277
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84001117
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80312506
52Chemical carcinogenesis_Homo sapiens_hsa052040.79684864
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77678694
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75459833
55Fatty acid metabolism_Homo sapiens_hsa012120.73698881
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71702205
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68260528
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67948954
59Alzheimers disease_Homo sapiens_hsa050100.67121339
60Nitrogen metabolism_Homo sapiens_hsa009100.64834731
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64460464
62Hedgehog signaling pathway_Homo sapiens_hsa043400.56818158
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56646169
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56531901
65TGF-beta signaling pathway_Homo sapiens_hsa043500.55775928
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52183519
67Metabolic pathways_Homo sapiens_hsa011000.51636126
68Fatty acid degradation_Homo sapiens_hsa000710.51475103
69Caffeine metabolism_Homo sapiens_hsa002320.51109709
70Viral carcinogenesis_Homo sapiens_hsa052030.50214279
71Hippo signaling pathway_Homo sapiens_hsa043900.46506822
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45037593
73Peroxisome_Homo sapiens_hsa041460.41196719
74Vitamin B6 metabolism_Homo sapiens_hsa007500.36540969
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36030136
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33617070
77Sulfur relay system_Homo sapiens_hsa041220.32966377
78Lysine degradation_Homo sapiens_hsa003100.32185464
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31330633
80Wnt signaling pathway_Homo sapiens_hsa043100.27545373
81Epstein-Barr virus infection_Homo sapiens_hsa051690.26810056
82beta-Alanine metabolism_Homo sapiens_hsa004100.26277881
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25686421
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.24690988
85Basal cell carcinoma_Homo sapiens_hsa052170.24085531
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23477195
87Prostate cancer_Homo sapiens_hsa052150.21452471
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17767138
89Retinol metabolism_Homo sapiens_hsa008300.16744798
90Steroid biosynthesis_Homo sapiens_hsa001000.16525958
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.16317344
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.14397191
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12472610
94HTLV-I infection_Homo sapiens_hsa051660.11941951
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11626801
96Fructose and mannose metabolism_Homo sapiens_hsa000510.09414829
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.09375863
98Galactose metabolism_Homo sapiens_hsa000520.08733929
99Small cell lung cancer_Homo sapiens_hsa052220.08048126
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.07845665

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